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Conserved domains on  [gi|575403042|ref|NP_001276399|]
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SLAM family member 5 isoform 3 precursor [Mus musculus]

Protein Classification

Ig_SLAM-like_N and Ig domain-containing protein( domain architecture ID 11617247)

Ig_SLAM-like_N and Ig domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 28-126 2.04e-34

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


:

Pssm-ID: 409517  Cd Length: 102  Bit Score: 121.66  E-value: 2.04e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403042  28 VMNGILGESVTFLLNIQEPKKIDNIAWTSQSSVAFIKPGVNKA-EVTITQGTYKGRIEIIDQKYDLVIRDLRMEDAGTYK 106
Cdd:cd16842    2 EVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAPGEGGApEIIITDKSYKERLNISQNDYSLQISNLTMEDAGSYR 81

                         90       100
                 ....*....|....*....|.
gi 575403042 107 ADINEENE-ETITKIYYLHIY 126
Cdd:cd16842   82 ARINTKNSrVTITKEFTLHIY 102
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 147-205 2.81e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member pfam00047:

Pssm-ID: 472250  Cd Length: 86  Bit Score: 39.10  E-value: 2.81e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 575403042  147 NITLTCSVEKEEKDVTYSWS------PFGEK---------SNVLQIVHSPMDQKLTYTCTAQNPVSNSSDSVTV 205
Cdd:pfam00047  13 SATLTCSASTGSPGPDVTWSkeggtlIESLKvkhdngrttQSSLLISNVTKEDAGTYTCVVNNPGGSATLSTSL 86
 
Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 28-126 2.04e-34

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 121.66  E-value: 2.04e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403042  28 VMNGILGESVTFLLNIQEPKKIDNIAWTSQSSVAFIKPGVNKA-EVTITQGTYKGRIEIIDQKYDLVIRDLRMEDAGTYK 106
Cdd:cd16842    2 EVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAPGEGGApEIIITDKSYKERLNISQNDYSLQISNLTMEDAGSYR 81

                         90       100
                 ....*....|....*....|.
gi 575403042 107 ADINEENE-ETITKIYYLHIY 126
Cdd:cd16842   82 ARINTKNSrVTITKEFTLHIY 102
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 26-126 8.32e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 43.99  E-value: 8.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403042   26 PVVMNGILGESVTFL--LNIQEPKKIDNIAWTSQSSVA----FIKPGVNKAEVTITQGTYKGRIEIIDQKYDLVIRDLRM 99
Cdd:pfam07686   3 PREVTVALGGSVTLPctYSSSMSEASTSVYWYRQPPGKgptfLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLTL 82

                          90       100
                  ....*....|....*....|....*..
gi 575403042  100 EDAGTYKADINEENEETITKIYYLHIY 126
Cdd:pfam07686  83 SDSGTYTCAVIPSGEGVFGKGTRLTVL 109
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 147-205 2.81e-04

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 39.10  E-value: 2.81e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 575403042  147 NITLTCSVEKEEKDVTYSWS------PFGEK---------SNVLQIVHSPMDQKLTYTCTAQNPVSNSSDSVTV 205
Cdd:pfam00047  13 SATLTCSASTGSPGPDVTWSkeggtlIESLKvkhdngrttQSSLLISNVTKEDAGTYTCVVNNPGGSATLSTSL 86
IgC1_CH2_IgA cd04986
CH2 domain (second constant Ig domain of the heavy chain) in immunoglobulin heavy alpha chain; ...
 142-205 6.09e-04

CH2 domain (second constant Ig domain of the heavy chain) in immunoglobulin heavy alpha chain; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin constant-1 set domain (IgC) of alpha heavy chains. This domain is found on the Fc fragment. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda; each is composed of a constant domain and a variable domain. There are five types of heavy chains: alpha, delta, epsilon, gamma, and mu, all consisting of a variable domain (VH) with three (alpha, delta and gamma) or four (epsilon and mu) constant domains (CH1 to CH4). Ig molecules are modular proteins, in which the variable and constant domains have clear, conserved sequence patterns. This group belongs to the C1-set of IgSF domains, which are classical Ig-like domains resembling the antibody constant domain. C1-set domains are found almost exclusively in molecules involved in the immune system, such as in immunoglobulin light and heavy chains, in the major histocompatibility complex (MHC) class I and II complex molecules, and in various T-cell receptors.


Pssm-ID: 409375  Cd Length: 96  Bit Score: 38.51  E-value: 6.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403042 142 LNNTCNITLTCSVEKEEKDVTYSWSPFGEK-----------------SNVLQIVHSPMDQKLTYTCTAQNPVSNSSDSVT 204
Cdd:cd04986   16 LGSNASLTCTLSGLKDPEGATFTWEPSGGKeaiqgpperdscgcysvSSVLPGCAEPWNSGDTFSCTVTHPESKGTLTAT 95


                 .
gi 575403042 205 V 205
Cdd:cd04986   96 I 96
 
Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 28-126 2.04e-34

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 121.66  E-value: 2.04e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403042  28 VMNGILGESVTFLLNIQEPKKIDNIAWTSQSSVAFIKPGVNKA-EVTITQGTYKGRIEIIDQKYDLVIRDLRMEDAGTYK 106
Cdd:cd16842    2 EVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAPGEGGApEIIITDKSYKERLNISQNDYSLQISNLTMEDAGSYR 81

                         90       100
                 ....*....|....*....|.
gi 575403042 107 ADINEENE-ETITKIYYLHIY 126
Cdd:cd16842   82 ARINTKNSrVTITKEFTLHIY 102
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 29-126 9.76e-08

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 49.27  E-value: 9.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403042  29 MNGILGESVTflLNIQE-PKKIDNIAW--TSQSSVAFikpgVNKAEVTITqGTYKGRIEIIDQKYDLVIRDLRMEDAGTY 105
Cdd:cd05775    5 VYGALGGNVT--LTISSlQDDIDEIKWkkTKDKIVEW----ENNIGPTYF-GSFKDRVLLDKESGSLTIKNLTKEDSGTY 77

                         90       100
                 ....*....|....*....|.
gi 575403042 106 KADINEENEETITKIYYLHIY 126
Cdd:cd05775   78 ELEITSTNGKVLSSKFTLEVL 98
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 26-126 8.32e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 43.99  E-value: 8.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403042   26 PVVMNGILGESVTFL--LNIQEPKKIDNIAWTSQSSVA----FIKPGVNKAEVTITQGTYKGRIEIIDQKYDLVIRDLRM 99
Cdd:pfam07686   3 PREVTVALGGSVTLPctYSSSMSEASTSVYWYRQPPGKgptfLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLTL 82

                          90       100
                  ....*....|....*....|....*..
gi 575403042  100 EDAGTYKADINEENEETITKIYYLHIY 126
Cdd:pfam07686  83 SDSGTYTCAVIPSGEGVFGKGTRLTVL 109
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 147-205 2.81e-04

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 39.10  E-value: 2.81e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 575403042  147 NITLTCSVEKEEKDVTYSWS------PFGEK---------SNVLQIVHSPMDQKLTYTCTAQNPVSNSSDSVTV 205
Cdd:pfam00047  13 SATLTCSASTGSPGPDVTWSkeggtlIESLKvkhdngrttQSSLLISNVTKEDAGTYTCVVNNPGGSATLSTSL 86
IgC1_CH2_IgA cd04986
CH2 domain (second constant Ig domain of the heavy chain) in immunoglobulin heavy alpha chain; ...
 142-205 6.09e-04

CH2 domain (second constant Ig domain of the heavy chain) in immunoglobulin heavy alpha chain; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin constant-1 set domain (IgC) of alpha heavy chains. This domain is found on the Fc fragment. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda; each is composed of a constant domain and a variable domain. There are five types of heavy chains: alpha, delta, epsilon, gamma, and mu, all consisting of a variable domain (VH) with three (alpha, delta and gamma) or four (epsilon and mu) constant domains (CH1 to CH4). Ig molecules are modular proteins, in which the variable and constant domains have clear, conserved sequence patterns. This group belongs to the C1-set of IgSF domains, which are classical Ig-like domains resembling the antibody constant domain. C1-set domains are found almost exclusively in molecules involved in the immune system, such as in immunoglobulin light and heavy chains, in the major histocompatibility complex (MHC) class I and II complex molecules, and in various T-cell receptors.


Pssm-ID: 409375  Cd Length: 96  Bit Score: 38.51  E-value: 6.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403042 142 LNNTCNITLTCSVEKEEKDVTYSWSPFGEK-----------------SNVLQIVHSPMDQKLTYTCTAQNPVSNSSDSVT 204
Cdd:cd04986   16 LGSNASLTCTLSGLKDPEGATFTWEPSGGKeaiqgpperdscgcysvSSVLPGCAEPWNSGDTFSCTVTHPESKGTLTAT 95


                 .
gi 575403042 205 V 205
Cdd:cd04986   96 I 96
Ig6_Contactin cd04970
Sixth immunoglobulin (Ig) domain of contactin; The members here are composed of the sixth ...
 133-205 3.08e-03

Sixth immunoglobulin (Ig) domain of contactin; The members here are composed of the sixth immunoglobulin (Ig) domain of contactins. Contactins are neural cell adhesion molecules and are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. The first four Ig domains form the intermolecular binding fragment, which arranges as a compact U-shaped module via contacts between Ig domains 1 and 4, and between Ig domains 2 and 3. Contactin-2 (TAG-1, axonin-1) may play a part in the neuronal processes of neurite outgrowth, axon guidance and fasciculation, and neuronal migration. This group also includes contactin-1 and contactin-5. The different contactins show different expression patterns in the central nervous system. During development and in adulthood, contactin-2 is transiently expressed in subsets of central and peripheral neurons. Contactin-5 is expressed specifically in the rat postnatal nervous system, peaking at about 3 weeks postnatal, and a lack of contactin-5 (NB-2) results in an impairment of neuronal activity in the rat auditory system. Contactin-5 is highly expressed in the adult human brain in the occipital lobe and in the amygdala. Contactin-1 is differentially expressed in tumor tissues and may, through a RhoA mechanism, facilitate invasion and metastasis of human lung adenocarcinoma.


Pssm-ID: 409359  Cd Length: 102  Bit Score: 36.76  E-value: 3.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403042 133 KITQSLISSLNNTC-NITLTCSVEKEEK-DVTYSWSPFG-----EKSNV-------------LQIVHSPMDQKLTYTCTA 192
Cdd:cd04970    4 RITLAPSNADITVGeNATLQCHASHDPTlDLTFTWSFNGvpidlEKIEGhyrrrygkdsngdLEIVNAQLKHAGRYTCTA 83

                         90
                 ....*....|...
gi 575403042 193 QNPVSNSSDSVTV 205
Cdd:cd04970   84 QTVVDSDSASATL 96
IgV_CEACAM_like cd05741
Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion ...
 30-125 7.85e-03

Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and related domains. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions: it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two (D1, D4) or four (D1-D4) Ig-like domains on the cell surface. This family corresponds to the D1 Ig-like domain. Also belonging to this group is the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84-like family. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. SLAM family proteins are organized as an extracellular domain with having two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409403  Cd Length: 102  Bit Score: 35.57  E-value: 7.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403042  30 NGILGESVTFLL-NIQEPKKidNIAWTSQSSVAF---IKPGVNKAEVTITQGTYKGRiEIIDQKYDLVIRDLRMEDAGTY 105
Cdd:cd05741    6 YGAEGKNVLLLVpNLQTPLK--SVSWYKGKQVSRndeIAEYENSSDEFRAGSAFSGR-EYIYTNGSLLIQNITLSDTGFY 82

                         90       100
                 ....*....|....*....|
gi 575403042 106 KADINEENEETITKIYYLHI 125
Cdd:cd05741   83 TLESTNIGGKTESATFQLHV 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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