NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|577861071|ref|NP_001276793|]
View 

period circadian protein homolog 3 isoform 5 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Period_C super family cl13540
Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is ...
 763-865 3.54e-25

Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is typically between 164 to 200 amino acids in length. This domain is found associated with pfam08447.


The actual alignment was detected with superfamily member pfam12114:

Pssm-ID: 463464  Cd Length: 171  Bit Score: 102.86  E-value: 3.54e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  763 SVYSSKISQNGQQSQDVQKKETF-PNVAEEPIWRMIRQTPERILMTYQVPERVKEVVLKEDLEKLESMRQQQPQFSHGQK 841
Cdd:pfam12114  68 SIDSSENNHKAKKTAEVGEEEHFiKCVLQDPIWLLMANTDDSVMMTYQIPSRDLETVLKEDREKLKAMQKMQPRFTEDQK 147

                          90       100
                  ....*....|....*....|....
gi 577861071  842 EELAKVYNWIQSQTVTQEIDIQAC 865
Cdd:pfam12114 148 GELAEVHPWIQKGGLPAALDLSEC 171
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 437-746 1.14e-06

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 52.61  E-value: 1.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  437 PDSSSSNTGSGPRRGAHQNAQPCCPSAA--------SSPHTSSPTFPPAAMVP-SQAPYLVPAFPLPAATSPGREYAAPG 507
Cdd:pfam05109 466 PTVSTADVTSPTPAGTTSGASPVTPSPSprdngtesKAPDMTSPTSAVTTPTPnATSPTPAVTTPTPNATSPTLGKTSPT 545

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  508 TAPEglhgLPLSEGLQPYPAFPFPYLDTFMTVFLPDPPVCPLLSPS-FLPCPFLGATASSAISPSMS----SAMSPTLDP 582
Cdd:pfam05109 546 SAVT----TPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTpNATSPTVGETSPQANTTNHTlggtSSTPVVTSP 621

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  583 PPSVTSqrreeekweAQSEGHPFITSRSSSPLQLNLLQ-EEMPRPSESPDQMRRNTCPQTEYCVTGNNGSESSPATTGA- 660
Cdd:pfam05109 622 PKNATS---------AVTTGQHNITSSSTSSMSLRPSSiSETLSPSTSDNSTSHMPLLTSAHPTGGENITQVTPASTSTh 692

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  661 -LSTGSP-PRenpshPTASALSTGSPPMKNPSHPTASALSTGSPPmKNPSHPTASTLSMGLPPSRTPSHPTATVLSTGSP 738
Cdd:pfam05109 693 hVSTSSPaPR-----PGTTSQASGPGNSSTSTKPGEVNVTKGTPP-KNATSPQAPSGQKTAVPTVTSTGGKANSTTGGKH 766


                  ....*...
gi 577861071  739 PSESPSRT 746
Cdd:pfam05109 767 TTGHGART 774
 
Name Accession Description Interval E-value
Period_C pfam12114
Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is ...
 763-865 3.54e-25

Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is typically between 164 to 200 amino acids in length. This domain is found associated with pfam08447.


Pssm-ID: 463464  Cd Length: 171  Bit Score: 102.86  E-value: 3.54e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  763 SVYSSKISQNGQQSQDVQKKETF-PNVAEEPIWRMIRQTPERILMTYQVPERVKEVVLKEDLEKLESMRQQQPQFSHGQK 841
Cdd:pfam12114  68 SIDSSENNHKAKKTAEVGEEEHFiKCVLQDPIWLLMANTDDSVMMTYQIPSRDLETVLKEDREKLKAMQKMQPRFTEDQK 147

                          90       100
                  ....*....|....*....|....
gi 577861071  842 EELAKVYNWIQSQTVTQEIDIQAC 865
Cdd:pfam12114 148 GELAEVHPWIQKGGLPAALDLSEC 171
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 437-746 1.14e-06

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 52.61  E-value: 1.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  437 PDSSSSNTGSGPRRGAHQNAQPCCPSAA--------SSPHTSSPTFPPAAMVP-SQAPYLVPAFPLPAATSPGREYAAPG 507
Cdd:pfam05109 466 PTVSTADVTSPTPAGTTSGASPVTPSPSprdngtesKAPDMTSPTSAVTTPTPnATSPTPAVTTPTPNATSPTLGKTSPT 545

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  508 TAPEglhgLPLSEGLQPYPAFPFPYLDTFMTVFLPDPPVCPLLSPS-FLPCPFLGATASSAISPSMS----SAMSPTLDP 582
Cdd:pfam05109 546 SAVT----TPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTpNATSPTVGETSPQANTTNHTlggtSSTPVVTSP 621

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  583 PPSVTSqrreeekweAQSEGHPFITSRSSSPLQLNLLQ-EEMPRPSESPDQMRRNTCPQTEYCVTGNNGSESSPATTGA- 660
Cdd:pfam05109 622 PKNATS---------AVTTGQHNITSSSTSSMSLRPSSiSETLSPSTSDNSTSHMPLLTSAHPTGGENITQVTPASTSTh 692

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  661 -LSTGSP-PRenpshPTASALSTGSPPMKNPSHPTASALSTGSPPmKNPSHPTASTLSMGLPPSRTPSHPTATVLSTGSP 738
Cdd:pfam05109 693 hVSTSSPaPR-----PGTTSQASGPGNSSTSTKPGEVNVTKGTPP-KNATSPQAPSGQKTAVPTVTSTGGKANSTTGGKH 766


                  ....*...
gi 577861071  739 PSESPSRT 746
Cdd:pfam05109 767 TTGHGART 774
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 434-746 2.58e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 51.33  E-value: 2.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  434 PEPPDSSSSNTGSGPRRG-AHQNAQPCCPSAASSPHTSSPtFPPAAMVPSQAPYLVPAFPLPAATSPGREYAAPGTAPEG 512
Cdd:PHA03307  114 PDPPPPTPPPASPPPSPApDLSEMLRPVGSPGPPPAASPP-AAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAE 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  513 LHGLPLSEGLQPYPafpfPYLDTFMTVFLPDPPVCPLLSPSFLPCPFLGATASSAISPSMSSAMSPTLDPPPS---VTSQ 589
Cdd:PHA03307  193 PPPSTPPAAASPRP----PRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPApitLPTR 268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  590 RREEEKWEAQSEGHPFITSRSSSPlqlnllqEEMPRPSESpdqmrrntcpqteycvtgNNGSESSPATTGALSTGSPPRE 669
Cdd:PHA03307  269 IWEASGWNGPSSRPGPASSSSSPR-------ERSPSPSPS------------------SPGSGPAPSSPRASSSSSSSRE 323

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 577861071  670 NPShptASALSTGSPPMKNPSHPTASALSTGSPPMKNPSHPTAStlsmglPPSRTPSHPTATVLSTgSPPSESPSRT 746
Cdd:PHA03307  324 SSS---SSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSS------PRKRPRPSRAPSSPAA-SAGRPTRRRA 390
 
Name Accession Description Interval E-value
Period_C pfam12114
Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is ...
 763-865 3.54e-25

Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is typically between 164 to 200 amino acids in length. This domain is found associated with pfam08447.


Pssm-ID: 463464  Cd Length: 171  Bit Score: 102.86  E-value: 3.54e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  763 SVYSSKISQNGQQSQDVQKKETF-PNVAEEPIWRMIRQTPERILMTYQVPERVKEVVLKEDLEKLESMRQQQPQFSHGQK 841
Cdd:pfam12114  68 SIDSSENNHKAKKTAEVGEEEHFiKCVLQDPIWLLMANTDDSVMMTYQIPSRDLETVLKEDREKLKAMQKMQPRFTEDQK 147

                          90       100
                  ....*....|....*....|....
gi 577861071  842 EELAKVYNWIQSQTVTQEIDIQAC 865
Cdd:pfam12114 148 GELAEVHPWIQKGGLPAALDLSEC 171
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 437-746 1.14e-06

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 52.61  E-value: 1.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  437 PDSSSSNTGSGPRRGAHQNAQPCCPSAA--------SSPHTSSPTFPPAAMVP-SQAPYLVPAFPLPAATSPGREYAAPG 507
Cdd:pfam05109 466 PTVSTADVTSPTPAGTTSGASPVTPSPSprdngtesKAPDMTSPTSAVTTPTPnATSPTPAVTTPTPNATSPTLGKTSPT 545

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  508 TAPEglhgLPLSEGLQPYPAFPFPYLDTFMTVFLPDPPVCPLLSPS-FLPCPFLGATASSAISPSMS----SAMSPTLDP 582
Cdd:pfam05109 546 SAVT----TPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTpNATSPTVGETSPQANTTNHTlggtSSTPVVTSP 621

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  583 PPSVTSqrreeekweAQSEGHPFITSRSSSPLQLNLLQ-EEMPRPSESPDQMRRNTCPQTEYCVTGNNGSESSPATTGA- 660
Cdd:pfam05109 622 PKNATS---------AVTTGQHNITSSSTSSMSLRPSSiSETLSPSTSDNSTSHMPLLTSAHPTGGENITQVTPASTSTh 692

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  661 -LSTGSP-PRenpshPTASALSTGSPPMKNPSHPTASALSTGSPPmKNPSHPTASTLSMGLPPSRTPSHPTATVLSTGSP 738
Cdd:pfam05109 693 hVSTSSPaPR-----PGTTSQASGPGNSSTSTKPGEVNVTKGTPP-KNATSPQAPSGQKTAVPTVTSTGGKANSTTGGKH 766


                  ....*...
gi 577861071  739 PSESPSRT 746
Cdd:pfam05109 767 TTGHGART 774
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 434-746 2.58e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 51.33  E-value: 2.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  434 PEPPDSSSSNTGSGPRRG-AHQNAQPCCPSAASSPHTSSPtFPPAAMVPSQAPYLVPAFPLPAATSPGREYAAPGTAPEG 512
Cdd:PHA03307  114 PDPPPPTPPPASPPPSPApDLSEMLRPVGSPGPPPAASPP-AAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAE 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  513 LHGLPLSEGLQPYPafpfPYLDTFMTVFLPDPPVCPLLSPSFLPCPFLGATASSAISPSMSSAMSPTLDPPPS---VTSQ 589
Cdd:PHA03307  193 PPPSTPPAAASPRP----PRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPApitLPTR 268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  590 RREEEKWEAQSEGHPFITSRSSSPlqlnllqEEMPRPSESpdqmrrntcpqteycvtgNNGSESSPATTGALSTGSPPRE 669
Cdd:PHA03307  269 IWEASGWNGPSSRPGPASSSSSPR-------ERSPSPSPS------------------SPGSGPAPSSPRASSSSSSSRE 323

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 577861071  670 NPShptASALSTGSPPMKNPSHPTASALSTGSPPMKNPSHPTAStlsmglPPSRTPSHPTATVLSTgSPPSESPSRT 746
Cdd:PHA03307  324 SSS---SSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSS------PRKRPRPSRAPSSPAA-SAGRPTRRRA 390
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 430-744 3.65e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 50.94  E-value: 3.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  430 RKKLPEPPDSSSSNTGSGPRRGAHQNAQPCCPSAASSPHTSSP-------------TFPPAAMVPSQAPYLVPAFPL-PA 495
Cdd:PHA03307   64 RFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPtppgpsspdppppTPPPASPPPSPAPDLSEMLRPvGS 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  496 ATSPGREYAAPGTAPEGLHGLPLSEGLQPYPAFPfpyldtfMTVFLPDPPVCPLLSPSFLPCPFLGATASSAISPSMSSA 575
Cdd:PHA03307  144 PGPPPAASPPAAGASPAAVASDAASSRQAALPLS-------SPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISAS 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  576 MsptldPPPSVTSQRREEEKWEAQSEGhpfiTSRSSSPLQLNLLQEEMPRPSESPDqmRRNTCPQTEycVTGNN-GSESS 654
Cdd:PHA03307  217 A-----SSPAPAPGRSAADDAGASSSD----SSSSESSGCGWGPENECPLPRPAPI--TLPTRIWEA--SGWNGpSSRPG 283

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  655 PATTGALSTGSPPRENPSHPTASALSTGSPPMKNPSHPTASALSTGSPPmKNPSHPTASTLSMGLPPSRTPSHPTATvlS 734
Cdd:PHA03307  284 PASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSS-SESSRGAAVSPGPSPSRSPSPSRPPPP--A 360

                         330
                  ....*....|
gi 577861071  735 TGSPPSESPS 744
Cdd:PHA03307  361 DPSSPRKRPR 370
PHA03247 PHA03247
large tegument protein UL36; Provisional
 436-741 3.96e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.09  E-value: 3.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  436 PPDSSSSNTGSGPRRGAhQNAQPCCPSAASSPHTSSPTFPPAAMVPSQAPYLVPAFPLPAATSPgreyaAPGTAPEGLHG 515
Cdd:PHA03247 2742 PAVPAGPATPGGPARPA-RPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDP-----ADPPAAVLAPA 2815

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  516 LPLSEGLQPYPAFPFPyldtfmTVFLPDPPVCPllsPSFLPCPFlgATASSAISPSMSSAMSPTLDPPPSVTSQRREEEK 595
Cdd:PHA03247 2816 AALPPAASPAGPLPPP------TSAQPTAPPPP---PGPPPPSL--PLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVR 2884

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  596 WEAQSEghpfiTSRSSSPLQLNLLQEEMPRPSESPDQMRRNTCPQTEYCVTGNNGSESSPATTGALSTGSPPRENPS--- 672
Cdd:PHA03247 2885 RLARPA-----VSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSgav 2959

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 577861071  673 -HPTASALSTGSPPMKN----PSHPTASALSTGSPPMKNPSHPTASTLSMGLPPSRTPSHPTATVLSTGSPPSE 741
Cdd:PHA03247 2960 pQPWLGALVPGRVAVPRfrvpQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQTLWPPDD 3033
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 433-743 4.62e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 50.54  E-value: 4.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  433 LPEPPDSSSSNTGSgprrgAHQNAQPCCPSAASSPHTSSPTFPPAAMVPSQAPylvPAFPLPAATSPGREYAAPGTAPEG 512
Cdd:pfam03154 148 IPSPQDNESDSDSS-----AQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAA---TAGPTPSAPSVPPQGSPATSQPPN 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  513 LHGLPLSEG--LQPYPAFPFPYLDTfmtvflPDPPVCPLLSPSflpcpflgatassaispsmssamsptldPPPSVTSQR 590
Cdd:pfam03154 220 QTQSTAAPHtlIQQTPTLHPQRLPS------PHPPLQPMTQPP----------------------------PPSQVSPQP 265

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  591 REEEKWEAQSE--GHPFITSRSSSPLQLNllqeemPRPSESPDQMRRNTCPQTEYCVTGNNGSESS--PATTGALSTGSP 666
Cdd:pfam03154 266 LPQPSLHGQMPpmPHSLQTGPSHMQHPVP------PQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIhtPPSQSQLQSQQP 339

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 577861071  667 PRENPSHPTASALSTGSPPMKNPSHPTASALSTGSPPmkNPSHPTASTLSMGLPPSrtPSHPTATVLSTGSPPSESP 743
Cdd:pfam03154 340 PREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPP--HLSGPSPFQMNSNLPPP--PALKPLSSLSTHHPPSAHP 412
PHA03247 PHA03247
large tegument protein UL36; Provisional
 420-744 6.53e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 6.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  420 SAGCRKGKHKRKKLPEPPDSSSSNTGSGPRRGAHQNAQPCCPSAASSPHTSSPTFPPAAMVPSQAPYLVPAFPLPAATSP 499
Cdd:PHA03247 2656 PAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPAL 2735

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  500 GREYAAPGTaPEGlHGLPLSEGLQPYPAFPfpyldtfMTVFLPDPPVCPLLSPS-FLPCPflgATASSAISPSMSSAMSP 578
Cdd:PHA03247 2736 PAAPAPPAV-PAG-PATPGGPARPARPPTT-------AGPPAPAPPAAPAAGPPrRLTRP---AVASLSESRESLPSPWD 2803

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  579 TLDPPPSVTSQRREEEKWEAQSEGHPFITSRSSSPLQLNllqeemPRPSESPDQMRRNTCPQTEYcvtGNNGSESSPATT 658
Cdd:PHA03247 2804 PADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPP------PGPPPPSLPLGGSVAPGGDV---RRRPPSRSPAAK 2874

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  659 GALSTGSP----PRENPSHPTASaLSTGSPPMKNPSHPTASALSTGSPPMKNPSHPTASTLSMGLPPSrtPSHPTATVLS 734
Cdd:PHA03247 2875 PAAPARPPvrrlARPAVSRSTES-FALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQP--PLAPTTDPAG 2951

                         330
                  ....*....|
gi 577861071  735 TGSPPSESPS 744
Cdd:PHA03247 2952 AGEPSGAVPQ 2961
PHA03247 PHA03247
large tegument protein UL36; Provisional
 436-743 1.14e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  436 PPDSSSSNTGSGPRRGAHQNAQPccpsAASSPHTSSPTFPPAAmvPSQAPYLVPAFPLPAATSPGREYAAPGTAPEGLHG 515
Cdd:PHA03247 2592 PPQSARPRAPVDDRGDPRGPAPP----SPLPPDTHAPDPPPPS--PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPR 2665

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  516 LPLSEGLQPYPAFPfpyldtfmtvflPDPPVCPLLSPSFLPCPFLGatassaispsmssamsptlDPPPSvtsQRREEEK 595
Cdd:PHA03247 2666 RARRLGRAAQASSP------------PQRPRRRAARPTVGSLTSLA-------------------DPPPP---PPTPEPA 2711

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  596 WEAQSEGHPfitsrssSPLQLNLLQEEMPRPSESPDQMRRNTCPQTEycvtGNNGSESSPATTGALSTGSPPRENPSHP- 674
Cdd:PHA03247 2712 PHALVSATP-------LPPGPAAARQASPALPAAPAPPAVPAGPATP----GGPARPARPPTTAGPPAPAPPAAPAAGPp 2780

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 577861071  675 ---TASALSTGSPPMKNPSHPTASALSTGSPPMKNPSHPTASTLSMGLPPSRTPShPTATVLSTGSPPSESP 743
Cdd:PHA03247 2781 rrlTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQ-PTAPPPPPGPPPPSLP 2851
PHA03247 PHA03247
large tegument protein UL36; Provisional
 433-744 1.75e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 1.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  433 LPEPPDSSSSNTGSGPRRGAHQNAQPCCPSAASSP-------HTSSPTFPPAAMVPSQAPYLVPAFPLPAATSPGREYAA 505
Cdd:PHA03247 2624 PDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPgrvsrprRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPP 2703

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  506 PGTAPE-----GLHGLPLSEGLQPYPAFPFPYLDTFMTVFLPDPPVCPlLSPSFLPCPFLGATASSAISPSMSSAMSPTL 580
Cdd:PHA03247 2704 PPPTPEpaphaLVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATP-GGPARPARPPTTAGPPAPAPPAAPAAGPPRR 2782

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  581 DPPPSVTSQrrEEEKWEAQSEGHPFITSRSSSPLQLNLLQEEMPRPSESPDQMRRNTCPQTEycvtgNNGSESSPATTGA 660
Cdd:PHA03247 2783 LTRPAVASL--SESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPP-----PGPPPPSLPLGGS 2855

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  661 LSTGSP-PRENPSHPTASALSTgsppmknPSHPTASALStgSPPMKNPSHPTASTlSMGLPPSRTPSHPTATVLSTGSPP 739
Cdd:PHA03247 2856 VAPGGDvRRRPPSRSPAAKPAA-------PARPPVRRLA--RPAVSRSTESFALP-PDQPERPPQPQAPPPPQPQPQPPP 2925


                  ....*
gi 577861071  740 SESPS 744
Cdd:PHA03247 2926 PPQPQ 2930
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 434-744 4.94e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.52  E-value: 4.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  434 PEPPDSSSSNTGSGPRRGAHQNAQPCCPSAASSPHTSSPTFPPAAMVPSQAPYLVPAFPLP-------AATSPGREYAAP 506
Cdd:pfam03154 185 SPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPhpplqpmTQPPPPSQVSPQ 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  507 GTAPEGLHGL--PLSEGLQ--------PYPAFPFPYLDTFMTVFLPDPPVCPLLSPS----FLPCPFLGATASSAISPSM 572
Cdd:pfam03154 265 PLPQPSLHGQmpPMPHSLQtgpshmqhPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSqqriHTPPSQSQLQSQQPPREQP 344

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  573 SSAMSPTL---DPPPSVTSQRREEekweAQSEGHPfitSRSSSPLQLNLLQEEMPRPSESPDQMRRNTCPQTEYcvtgnn 649
Cdd:pfam03154 345 LPPAPLSMphiKPPPTTPIPQLPN----PQSHKHP---PHLSGPSPFQMNSNLPPPPALKPLSSLSTHHPPSAH------ 411

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  650 gsessPATTGALSTGSPPRENPSHPTASALSTGSPPmKNPSHPTASALSTGSPPMKNPSHPTASTLSMGLPPSRTPSHPT 729
Cdd:pfam03154 412 -----PPPLQLMPQSQQLPPPPAQPPVLTQSQSLPP-PAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTST 485

                         330
                  ....*....|....*
gi 577861071  730 ATVLSTGSPPSESPS 744
Cdd:pfam03154 486 SSAMPGIQPPSSASV 500
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 620-767 5.17e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 5.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  620 QEEMPRPSESPDQMRRNTCPQTEYCVTGNNGSESSPATTGALSTGSPPRENPSHPTASALSTGS--PPMKNPSHPTASAL 697
Cdd:PHA03307   69 TGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPdlSEMLRPVGSPGPPP 148

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071  698 STGSPPMKNPSHPTASTLSMGLPPSRTPSHPTATVLSTGSPPSESPSRTGSAASGSSDSSIYLTSSVYSS 767
Cdd:PHA03307  149 AASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASAS 218
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
440-696 7.87e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 39.86  E-value: 7.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071 440 SSSNTGSGPRRGAhqnaqpCCPSAASSPHTSSPTFPPAAMVPSQAPYLVPAFPLPAATSPGREYAAPGTAPEGLHGLPLS 519
Cdd:PRK12323 366 GQSGGGAGPATAA------AAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQA 439

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071 520 EGLQPYPAfpfpyldtfmtvflPDPPVCPLLSPSFLPCPflgATASSAISPSMSSAMSPTLDPPPSVTSQRREEEKWEAQ 599
Cdd:PRK12323 440 SARGPGGA--------------PAPAPAPAAAPAAAARP---AAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEEL 502

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071 600 SEGHPFITSRSSSPLQLNLLQEEMPRPSESPDQMRRNTCPQteycvtgnngsESSPATTGALSTGSPPRENPSHPTASAl 679
Cdd:PRK12323 503 PPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAP-----------APAAAPAPRAAAATEPVVAPRPPRASA- 570

                        250
                 ....*....|....*..
gi 577861071 680 sTGSPPMKNPSHPTASA 696
Cdd:PRK12323 571 -SGLPDMFDGDWPALAA 586
PLN02217 PLN02217
probable pectinesterase/pectinesterase inhibitor
 639-746 9.20e-03

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 39.69  E-value: 9.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861071 639 PQTEYCVTGNNGSESSPATTGALSTGSPprENPSHPTASALSTGSPPMKNPSHPTASALSTGSPPMKNPSHptastlSMG 718
Cdd:PLN02217 556 PYIPGLFAGNPGSTNSTPTGSAASSNTT--FSSDSPSTVVAPSTSPPAGHLGSPPATPSKIVSPSTSPPAS------HLG 627

                         90       100
                 ....*....|....*....|....*...
gi 577861071 719 LPPSrTPSHPTATVLSTGSpPSESPSRT 746
Cdd:PLN02217 628 SPST-TPSSPESSIKVAST-ETASPESS 653
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH