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Conserved domains on  [gi|602152739|ref|NP_001278202|]
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small ribosomal subunit protein mS23 isoform c [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MRP-S23 super family cl46259
Mitochondrial ribosomal protein S23; MRP-S23 is one of the proteins that makes up the 55S ...
 2-73 8.73e-27

Mitochondrial ribosomal protein S23; MRP-S23 is one of the proteins that makes up the 55S ribosome in eukaryotes from nematodes to humans. It does not appear to carry any common motifs, either RNA binding or ribosomal protein motifs. All of the mammalian MRPs are encoded in nuclear genes that are evolving more rapidly than those encoding cytoplasmic ribosomal proteins. The MRPs are imported into mitochondria where they assemble coordinately with mitochondrially transcribed rRNAs into ribosomes that are responsible for translating the 13 mRNAs for essential proteins of the oxidative phosphorylation system. MRP-S23 is significantly up-regulated in uterine cancer cells.


The actual alignment was detected with superfamily member pfam10484:

Pssm-ID: 463108  Cd Length: 128  Bit Score: 96.17  E-value: 8.73e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602152739    2 AGSRLETVGSVFSR--------------------------------------------------------KFFATYGSGQ 25
Cdd:pfam10484   1 AGSRLEKFGTIFTRvrdllrsgvlkeeekplwydvyeafppkreplynrpapriedpvreifyeedviraKFYKVYGNGP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 602152739   26 KAFDLFNPNFKSTCQRFVEKYTELQNLGETDEEKLFVETGKALLAEGI 73
Cdd:pfam10484  81 RAFNLLDPNFKSTCQRFVEKYQELKKQGELDEEELFEETEKALLEEGI 128
 
Name Accession Description Interval E-value
MRP-S23 pfam10484
Mitochondrial ribosomal protein S23; MRP-S23 is one of the proteins that makes up the 55S ...
 2-73 8.73e-27

Mitochondrial ribosomal protein S23; MRP-S23 is one of the proteins that makes up the 55S ribosome in eukaryotes from nematodes to humans. It does not appear to carry any common motifs, either RNA binding or ribosomal protein motifs. All of the mammalian MRPs are encoded in nuclear genes that are evolving more rapidly than those encoding cytoplasmic ribosomal proteins. The MRPs are imported into mitochondria where they assemble coordinately with mitochondrially transcribed rRNAs into ribosomes that are responsible for translating the 13 mRNAs for essential proteins of the oxidative phosphorylation system. MRP-S23 is significantly up-regulated in uterine cancer cells.


Pssm-ID: 463108  Cd Length: 128  Bit Score: 96.17  E-value: 8.73e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602152739    2 AGSRLETVGSVFSR--------------------------------------------------------KFFATYGSGQ 25
Cdd:pfam10484   1 AGSRLEKFGTIFTRvrdllrsgvlkeeekplwydvyeafppkreplynrpapriedpvreifyeedviraKFYKVYGNGP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 602152739   26 KAFDLFNPNFKSTCQRFVEKYTELQNLGETDEEKLFVETGKALLAEGI 73
Cdd:pfam10484  81 RAFNLLDPNFKSTCQRFVEKYQELKKQGELDEEELFEETEKALLEEGI 128
 
Name Accession Description Interval E-value
MRP-S23 pfam10484
Mitochondrial ribosomal protein S23; MRP-S23 is one of the proteins that makes up the 55S ...
 2-73 8.73e-27

Mitochondrial ribosomal protein S23; MRP-S23 is one of the proteins that makes up the 55S ribosome in eukaryotes from nematodes to humans. It does not appear to carry any common motifs, either RNA binding or ribosomal protein motifs. All of the mammalian MRPs are encoded in nuclear genes that are evolving more rapidly than those encoding cytoplasmic ribosomal proteins. The MRPs are imported into mitochondria where they assemble coordinately with mitochondrially transcribed rRNAs into ribosomes that are responsible for translating the 13 mRNAs for essential proteins of the oxidative phosphorylation system. MRP-S23 is significantly up-regulated in uterine cancer cells.


Pssm-ID: 463108  Cd Length: 128  Bit Score: 96.17  E-value: 8.73e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602152739    2 AGSRLETVGSVFSR--------------------------------------------------------KFFATYGSGQ 25
Cdd:pfam10484   1 AGSRLEKFGTIFTRvrdllrsgvlkeeekplwydvyeafppkreplynrpapriedpvreifyeedviraKFYKVYGNGP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 602152739   26 KAFDLFNPNFKSTCQRFVEKYTELQNLGETDEEKLFVETGKALLAEGI 73
Cdd:pfam10484  81 RAFNLLDPNFKSTCQRFVEKYQELKKQGELDEEELFEETEKALLEEGI 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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