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Conserved domains on  [gi|618468299|ref|NP_001278532|]
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dynein light chain Tctex-type 1 isoform 3 [Homo sapiens]

Protein Classification

dynein light chain family protein( domain architecture ID 1750150)

dynein light chain family protein may act as an ATPase that generates force towards the minus end of microtubules, function as a non-catalytic accessory component of the cytoplasmic dynein complex, or play a functional role that has not yet been characterized

CATH:  3.30.740.10
Gene Ontology:  GO:0007017|GO:0030286
SCOP:  3000821

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DLC-like_SF super family cl41776
dynein light chain (DLC)-like domain superfamily; The superfamily corresponds to a class of ...
 12-64 3.35e-33

dynein light chain (DLC)-like domain superfamily; The superfamily corresponds to a class of proteins containing a dynein light chain (DLC)-like domain with anti-parallel beta-sheet packed against an alpha-helical hairpin. DLC-like domain-containing proteins includes cytoplasmic dynein light chain DYNLL1 and DYNLL2, axonemal dynein light chain 4 (DNAL4), tegumental-allergen-like proteins (TALs), dynein light chain Tctex-type DYNLT1 and DYNLT3, as well as Tctex1 domain-containing proteins (TCTEX1D). Both DYNLL1 and DYNLL2 are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. DNAL4 is a force generating protein of respiratory cilia. TALs may be involved in the transport of vesicles within the tegumental cytoplasm, probably within dynein motor complexes. DYNLT1 and DYNLT3, which contribute to the differential regulation of dynein cargo binding. They are non-catalytic accessory components of the cytoplasmic dynein 1 complex, which contains either DYNLT1 or DYNLT3, but not both. TCTEX1D family includes TCTEX1D1-4. TCTEX1D1 is a genetic modifier of disease progression in Duchenne muscular dystrophy (DMD). TCTEX1D2 is required for proper retrograde ciliary transport. TCTEX1D3 may be an accessory component of axonemal dynein and cytoplasmic dynein 1. TCTEX1D4 is a novel protein phosphatase 1 (PPP1) interactor.


The actual alignment was detected with superfamily member cd21462:

Pssm-ID: 425407  Cd Length: 102  Bit Score: 109.86  E-value: 3.35e-33
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 618468299  12 FVVDEVSNIVKEAIESAIGGNAYQHSKVNQWTTNVVEQTLSQLTKLGKPFKYI 64
Cdd:cd21462    1 FVVDEVSNIIKEAIESTIGGNAYQHNKVNQWTSNVVEQCLNQLTKLGKPFKYI 53
 
Name Accession Description Interval E-value
DLC-like_DYNLT1 cd21462
dynein light chain (DLC)-like domain found in dynein light chain Tctex-type 1 (DYNLT1) and ...
 12-64 3.35e-33

dynein light chain (DLC)-like domain found in dynein light chain Tctex-type 1 (DYNLT1) and similar proteins; Dynein light chain Tctex-type 1 (DYNLT1), also called TCTEL1, or TCTEX1, or protein CW-1, or T-complex testis-specific protein 1 homolog, is a non-catalytic accessory component of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. It plays a role in neuronal morphogenesis. It is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. The model corresponds to the dynein light chain (DLC)-like domain of DYNLT1.


Pssm-ID: 412010  Cd Length: 102  Bit Score: 109.86  E-value: 3.35e-33
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 618468299  12 FVVDEVSNIVKEAIESAIGGNAYQHSKVNQWTTNVVEQTLSQLTKLGKPFKYI 64
Cdd:cd21462    1 FVVDEVSNIIKEAIESTIGGNAYQHNKVNQWTSNVVEQCLNQLTKLGKPFKYI 53
Tctex-1 pfam03645
Tctex-1 family; Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to ...
 16-64 3.25e-13

Tctex-1 family; Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to the cytoplasmic tail of rhodopsin. C-terminal rhodopsin mutations responsible for retinitis pigmentosa inhibit this interaction.


Pssm-ID: 461003  Cd Length: 96  Bit Score: 59.08  E-value: 3.25e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 618468299  16 EVSNIVKEAIESAIGGNA-YQHSKVNQWTTNVVEQTLSQLTKLG-KPFKYI 64
Cdd:pfam03645  1 EVKEIIKEVLEEVLGGGEtYDHEKVPQWTKEISEEILDRLKELGfKRYKYI 51
 
Name Accession Description Interval E-value
DLC-like_DYNLT1 cd21462
dynein light chain (DLC)-like domain found in dynein light chain Tctex-type 1 (DYNLT1) and ...
 12-64 3.35e-33

dynein light chain (DLC)-like domain found in dynein light chain Tctex-type 1 (DYNLT1) and similar proteins; Dynein light chain Tctex-type 1 (DYNLT1), also called TCTEL1, or TCTEX1, or protein CW-1, or T-complex testis-specific protein 1 homolog, is a non-catalytic accessory component of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. It plays a role in neuronal morphogenesis. It is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. The model corresponds to the dynein light chain (DLC)-like domain of DYNLT1.


Pssm-ID: 412010  Cd Length: 102  Bit Score: 109.86  E-value: 3.35e-33
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 618468299  12 FVVDEVSNIVKEAIESAIGGNAYQHSKVNQWTTNVVEQTLSQLTKLGKPFKYI 64
Cdd:cd21462    1 FVVDEVSNIIKEAIESTIGGNAYQHNKVNQWTSNVVEQCLNQLTKLGKPFKYI 53
DLC-like_DYNLT1_DYNLT3 cd21455
dynein light chain (DLC)-like domain found in the dynein light chain Tctex-type 1 (DYNLT1) ...
 15-64 3.14e-21

dynein light chain (DLC)-like domain found in the dynein light chain Tctex-type 1 (DYNLT1) family; The dynein light chain Tctex-type 1 (DYNLT1) family includes two isoforms, DYNLT1 and DYNLT3, which contribute to the differential regulation of dynein cargo binding. They are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. The dynein complex contains either DYNLT1 or DYNLT3, but not both. The model corresponds to the dynein light chain (DLC)-like domain of DYNLT1 and DYNLT3.


Pssm-ID: 412003  Cd Length: 97  Bit Score: 79.54  E-value: 3.14e-21
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 618468299 15 DEVSNIVKEAIESAIGGNAYQHSKVNQWTTNVVEQTLSQLTKLGKPFKYI 64
Cdd:cd21455   1 EEVESIVKEAIEAVLGDKTYSHSKVNQWSNSIVEEILKRLAKLNKPFKYI 50
DLC-like_DYNLT3 cd21463
dynein light chain (DLC)-like domain found in dynein light chain Tctex-type 3 (DYNLT3) and ...
 15-64 1.30e-19

dynein light chain (DLC)-like domain found in dynein light chain Tctex-type 3 (DYNLT3) and similar proteins; Dynein light chain Tctex-type 3 (DYNLT3), also called rp3, or protein 91/23, or T-complex-associated testis-expressed 1-like, is a non-catalytic accessory component of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. It has a potential role in chromosome congression in human mitosis and is required for chromosome alignment during mouse oocyte meiotic maturation. The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3. The model corresponds to the dynein light chain (DLC)-like domain of DYNLT3.


Pssm-ID: 412011  Cd Length: 97  Bit Score: 75.32  E-value: 1.30e-19
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 618468299 15 DEVSNIVKEAIESAIGGNAYQHSKVNQWTTNVVEQTLSQLTKLGKPFKYI 64
Cdd:cd21463   1 DEASNVVKECIEGILGGVDYNHNKINQWTAAIVEQSLTHLVKLGKPFKYI 50
DLC-like_DYNLT1-like cd21448
dynein light chain (DLC)-like domain found in the dynein light chain Tctex-type 1 (DYNLT1) ...
 15-64 7.82e-16

dynein light chain (DLC)-like domain found in the dynein light chain Tctex-type 1 (DYNLT1) subfamily and similar proteins; The dynein light chain Tctex-type 1 (DYNLT1) subfamily includes two isoforms, DYNLT1 and DYNLT3, which contribute to the differential regulation of dynein cargo binding. They are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. The dynein complex contains either DYNLT1 or DYNLT3, but not both. The family also includes Schizosaccharomyces pombe dynein light chain Tctex-type (SpDlc1), Saccharomyces cerevisiae topoisomerase I damage affected protein 2 (TDA2) and similar proteins. SpDlc1 belongs to the 14-kDa Tctex-1 dynein light chain family. It acts as a non-catalytic accessory component of a dynein complex. It is required for regular oscillatory nuclear movement and efficient recombination during meiotic prophase in fission yeast. TDA2 is a novel protein of the endocytic machinery necessary for normal internalization of native cargo in yeast. It works independently of the dynein motor complex and microtubules.


Pssm-ID: 411996  Cd Length: 98  Bit Score: 65.93  E-value: 7.82e-16
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 618468299 15 DEVSNIVKEAIESAIGGNAYQHSKVNQWTTNVVEQTLSQLTKLGK-PFKYI 64
Cdd:cd21448   1 RKLVTIIQEAIDSALDDNEYDHAKTESWSNLIIKLVLSELEKLSKsPFKYI 51
Tctex-1 pfam03645
Tctex-1 family; Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to ...
 16-64 3.25e-13

Tctex-1 family; Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to the cytoplasmic tail of rhodopsin. C-terminal rhodopsin mutations responsible for retinitis pigmentosa inhibit this interaction.


Pssm-ID: 461003  Cd Length: 96  Bit Score: 59.08  E-value: 3.25e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 618468299  16 EVSNIVKEAIESAIGGNA-YQHSKVNQWTTNVVEQTLSQLTKLG-KPFKYI 64
Cdd:pfam03645  1 EVKEIIKEVLEEVLGGGEtYDHEKVPQWTKEISEEILDRLKELGfKRYKYI 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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