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Conserved domains on  [gi|1823752938|ref|NP_001278552|]
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inward rectifier potassium channel 16 isoform b [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
IRK_C pfam17655
Inward rectifier potassium channel C-terminal domain; This cytoplasmic C-terminal domain has ...
182-349 7.78e-84

Inward rectifier potassium channel C-terminal domain; This cytoplasmic C-terminal domain has an Ig fold.


:

Pssm-ID: 465439  Cd Length: 174  Bit Score: 254.05  E-value: 7.78e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752938 182 IRFSYFALIGMRDGKLCLMWRIGDFRPNHVVEGTVRAQLLRYTEDSEGR-MTMAFKDLKLV----NDQIILVTPVTIVHE 256
Cdd:pfam17655   1 LKFSKNAVICQRDGKLCLMFRVGDLRKSHLIEAHVRAQLLKTRVTKEGEvIPLYQVDLDLGvdtgSDRIFLVWPLTVYHV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752938 257 IDHESPLYALDRKAVAKDNFEILVTFIYTGDSTGTSHQSRSSYVPREILWGHRFNDVLEVKRK-YYKVNCLQFEGSVEVY 335
Cdd:pfam17655  81 IDEDSPLYDLSAKDLLEEDFELVVILEGTVESTGMTTQARTSYLPEEILWGHRFEPVISYSKEgRYVVDYSNFDKTVEVP 160
                         170
                  ....*....|....
gi 1823752938 336 APFCSAKQLDWKDQ 349
Cdd:pfam17655 161 TPHCSAKELDEKKQ 174
IRK pfam01007
Inward rectifier potassium channel transmembrane domain;
37-173 3.61e-77

Inward rectifier potassium channel transmembrane domain;


:

Pssm-ID: 460023  Cd Length: 141  Bit Score: 235.54  E-value: 3.61e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752938  37 LHKDGSCNVYFKHIFGEWGSYVVDIFTTLVDTKWRHMFVIFSLSYILSWLIFGSVFWLIAFHHGDLL--NDPDITPCVDN 114
Cdd:pfam01007   1 VSKNGHCNVVFTNIPEKSLRYLQDIFTTLVDLKWRYMLLLFSLSFVLSWLIFGLIWYLIAYSHGDLDqrPDDGHTPCVYN 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1823752938 115 VHSFTGAFLFSLETQTTIGYGYRCVTEECSVAVLMVILQSILSCIINTFIIGAALAKMA 173
Cdd:pfam01007  81 VHSFTSAFLFSIETQTTIGYGFRYVTEECPEAIFLLVFQSIVGCLIDAFMIGIVFAKMA 139
 
Name Accession Description Interval E-value
IRK_C pfam17655
Inward rectifier potassium channel C-terminal domain; This cytoplasmic C-terminal domain has ...
182-349 7.78e-84

Inward rectifier potassium channel C-terminal domain; This cytoplasmic C-terminal domain has an Ig fold.


Pssm-ID: 465439  Cd Length: 174  Bit Score: 254.05  E-value: 7.78e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752938 182 IRFSYFALIGMRDGKLCLMWRIGDFRPNHVVEGTVRAQLLRYTEDSEGR-MTMAFKDLKLV----NDQIILVTPVTIVHE 256
Cdd:pfam17655   1 LKFSKNAVICQRDGKLCLMFRVGDLRKSHLIEAHVRAQLLKTRVTKEGEvIPLYQVDLDLGvdtgSDRIFLVWPLTVYHV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752938 257 IDHESPLYALDRKAVAKDNFEILVTFIYTGDSTGTSHQSRSSYVPREILWGHRFNDVLEVKRK-YYKVNCLQFEGSVEVY 335
Cdd:pfam17655  81 IDEDSPLYDLSAKDLLEEDFELVVILEGTVESTGMTTQARTSYLPEEILWGHRFEPVISYSKEgRYVVDYSNFDKTVEVP 160
                         170
                  ....*....|....
gi 1823752938 336 APFCSAKQLDWKDQ 349
Cdd:pfam17655 161 TPHCSAKELDEKKQ 174
IRK pfam01007
Inward rectifier potassium channel transmembrane domain;
37-173 3.61e-77

Inward rectifier potassium channel transmembrane domain;


Pssm-ID: 460023  Cd Length: 141  Bit Score: 235.54  E-value: 3.61e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752938  37 LHKDGSCNVYFKHIFGEWGSYVVDIFTTLVDTKWRHMFVIFSLSYILSWLIFGSVFWLIAFHHGDLL--NDPDITPCVDN 114
Cdd:pfam01007   1 VSKNGHCNVVFTNIPEKSLRYLQDIFTTLVDLKWRYMLLLFSLSFVLSWLIFGLIWYLIAYSHGDLDqrPDDGHTPCVYN 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1823752938 115 VHSFTGAFLFSLETQTTIGYGYRCVTEECSVAVLMVILQSILSCIINTFIIGAALAKMA 173
Cdd:pfam01007  81 VHSFTSAFLFSIETQTTIGYGFRYVTEECPEAIFLLVFQSIVGCLIDAFMIGIVFAKMA 139
 
Name Accession Description Interval E-value
IRK_C pfam17655
Inward rectifier potassium channel C-terminal domain; This cytoplasmic C-terminal domain has ...
182-349 7.78e-84

Inward rectifier potassium channel C-terminal domain; This cytoplasmic C-terminal domain has an Ig fold.


Pssm-ID: 465439  Cd Length: 174  Bit Score: 254.05  E-value: 7.78e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752938 182 IRFSYFALIGMRDGKLCLMWRIGDFRPNHVVEGTVRAQLLRYTEDSEGR-MTMAFKDLKLV----NDQIILVTPVTIVHE 256
Cdd:pfam17655   1 LKFSKNAVICQRDGKLCLMFRVGDLRKSHLIEAHVRAQLLKTRVTKEGEvIPLYQVDLDLGvdtgSDRIFLVWPLTVYHV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752938 257 IDHESPLYALDRKAVAKDNFEILVTFIYTGDSTGTSHQSRSSYVPREILWGHRFNDVLEVKRK-YYKVNCLQFEGSVEVY 335
Cdd:pfam17655  81 IDEDSPLYDLSAKDLLEEDFELVVILEGTVESTGMTTQARTSYLPEEILWGHRFEPVISYSKEgRYVVDYSNFDKTVEVP 160
                         170
                  ....*....|....
gi 1823752938 336 APFCSAKQLDWKDQ 349
Cdd:pfam17655 161 TPHCSAKELDEKKQ 174
IRK pfam01007
Inward rectifier potassium channel transmembrane domain;
37-173 3.61e-77

Inward rectifier potassium channel transmembrane domain;


Pssm-ID: 460023  Cd Length: 141  Bit Score: 235.54  E-value: 3.61e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1823752938  37 LHKDGSCNVYFKHIFGEWGSYVVDIFTTLVDTKWRHMFVIFSLSYILSWLIFGSVFWLIAFHHGDLL--NDPDITPCVDN 114
Cdd:pfam01007   1 VSKNGHCNVVFTNIPEKSLRYLQDIFTTLVDLKWRYMLLLFSLSFVLSWLIFGLIWYLIAYSHGDLDqrPDDGHTPCVYN 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1823752938 115 VHSFTGAFLFSLETQTTIGYGYRCVTEECSVAVLMVILQSILSCIINTFIIGAALAKMA 173
Cdd:pfam01007  81 VHSFTSAFLFSIETQTTIGYGFRYVTEECPEAIFLLVFQSIVGCLIDAFMIGIVFAKMA 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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