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Conserved domains on  [gi|630044901|ref|NP_001278809|]
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protein Wnt-2b isoform 3 [Homo sapiens]

Protein Classification

wnt family protein( domain architecture ID 1562737)

wnt family protein may function in development and differentiation

Gene Ontology:  GO:0016055|GO:0005102|GO:0005576
PubMed:  22952392|20477987|8167409
SCOP:  4005649|4007801

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Wnt super family cl38924
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
 1-288 0e+00

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


The actual alignment was detected with superfamily member cd19346:

Pssm-ID: 393294  Cd Length: 314  Bit Score: 552.22  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901   1 MRSVGEGAREWIRECQHQFRHHRWNCTTLDRDHTVFGRVMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDPYT 80
Cdd:cd19346   27 MQSIGEGAKEWIRECQHQFRHHRWNCSTLDRDHTVFGRVMLRSSREAAFVYAISSAGVVYAITRACSQGELKSCSCDPHK 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901  81 RGRHHDQRGDFDWGGCSDNIHYGVRFAKAFVDAKEKRLKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCW 160
Cdd:cd19346  107 RGRSHDERGEFDWGGCSDNINYGIKFAKAFVDAKEKKEKDARALMNLHNNRCGRMAVKRFMKLECKCHGVSGSCTLRTCW 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901 161 RALSDFRRTGDYLRRRYDGAVQVMATQDGANFTAARQGYRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKTSKGT 240
Cdd:cd19346  187 LAMSDFRKTGDYLRKRYNGAVQVTMNQDGTGFTVANKNFRKATKTDLVYFENSPDYCVMDKSAGSLGTAGRVCNKSSRGT 266

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 630044901 241 DGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCK 288
Cdd:cd19346  267 DGCEVMCCGRGYDTTRVTRVTKCECKFHWCCAVRCKECEETVDVHTCK 314
 
Name Accession Description Interval E-value
Wnt_Wnt2b cd19346
Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, ...
 1-288 0e+00

Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381720  Cd Length: 314  Bit Score: 552.22  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901   1 MRSVGEGAREWIRECQHQFRHHRWNCTTLDRDHTVFGRVMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDPYT 80
Cdd:cd19346   27 MQSIGEGAKEWIRECQHQFRHHRWNCSTLDRDHTVFGRVMLRSSREAAFVYAISSAGVVYAITRACSQGELKSCSCDPHK 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901  81 RGRHHDQRGDFDWGGCSDNIHYGVRFAKAFVDAKEKRLKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCW 160
Cdd:cd19346  107 RGRSHDERGEFDWGGCSDNINYGIKFAKAFVDAKEKKEKDARALMNLHNNRCGRMAVKRFMKLECKCHGVSGSCTLRTCW 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901 161 RALSDFRRTGDYLRRRYDGAVQVMATQDGANFTAARQGYRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKTSKGT 240
Cdd:cd19346  187 LAMSDFRKTGDYLRKRYNGAVQVTMNQDGTGFTVANKNFRKATKTDLVYFENSPDYCVMDKSAGSLGTAGRVCNKSSRGT 266

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 630044901 241 DGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCK 288
Cdd:cd19346  267 DGCEVMCCGRGYDTTRVTRVTKCECKFHWCCAVRCKECEETVDVHTCK 314
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 1-288 1.72e-171

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 476.66  E-value: 1.72e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901    1 MRSVGEGAREWIRECQHQFRHHRWNCTTLDRDHTVFGRVMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDPyT 80
Cdd:pfam00110  20 MASVAEGAQLAIEECQHQFRNRRWNCSTLENKRPVFGKVLKRGTRETAFVYAISSAGVTHAVTRACSSGELTSCGCDR-K 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901   81 RGRHHDQRGDFDWGGCSDNIHYGVRFAKAFVDAKEKRLKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCW 160
Cdd:pfam00110  99 KRGKSSGEGGWEWGGCSDNIDYGYKFSRKFVDAREKKRRDARALMNLHNNEAGRKAVKSNMRTECKCHGVSGSCSVKTCW 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901  161 RALSDFRRTGDYLRRRYDGAVQV-MATQDGANFTAARQGYRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKTSKG 239
Cdd:pfam00110 179 KALPPFREVGDRLKEKYDGAVKVnRRRNKRGRLVPRNSRFKPPTKNDLVYLEKSPDYCERNPKTGSLGTRGRECNKTSSG 258

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 630044901  240 TDGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCK 288
Cdd:pfam00110 259 PDGCDLLCCGRGYNTRTVTVTERCNCKFHWCCYVKCKTCTETVEVYTCK 307
WNT1 smart00097
found in Wnt-1;
1-288 2.57e-147

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 415.57  E-value: 2.57e-147
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901     1 MRSVGEGAREWIRECQHQFRHHRWNCTTLDrDHTVFGRVMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDPYT 80
Cdd:smart00097  20 MISVAEGAQEGIEECQHQFRFRRWNCSTLD-NASVFGKVLRQGTRETAFVYAISSAGVAHAVTRACSEGELDSCGCDYRK 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901    81 RGRhhDQRGDFDWGGCSDNIHYGVRFAKAFVDAKEKRlKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCW 160
Cdd:smart00097  99 RGR--AGGRGWKWGGCSDNIDFGIRFSREFVDARERG-KDARALMNLHNNEAGRLAVKKTMKRECKCHGVSGSCTVKTCW 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901   161 RALSDFRRTGDYLRRRYDGAVQVMATQDGANFTAARQG--YRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKTSK 238
Cdd:smart00097 176 LQLPDFRKVGDYLKEKYDGASEVEVDKRGTNKAPVPKNstFKPPTETDLVYLESSPDFCEKNPKTGSLGTQGRQCNKTSK 255

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 630044901   239 GTDGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCK 288
Cdd:smart00097 256 GLDGCDLLCCGRGYNTRTVEVVERCNCKFHWCCYVKCKQCRETVEKHTCK 305
 
Name Accession Description Interval E-value
Wnt_Wnt2b cd19346
Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, ...
 1-288 0e+00

Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381720  Cd Length: 314  Bit Score: 552.22  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901   1 MRSVGEGAREWIRECQHQFRHHRWNCTTLDRDHTVFGRVMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDPYT 80
Cdd:cd19346   27 MQSIGEGAKEWIRECQHQFRHHRWNCSTLDRDHTVFGRVMLRSSREAAFVYAISSAGVVYAITRACSQGELKSCSCDPHK 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901  81 RGRHHDQRGDFDWGGCSDNIHYGVRFAKAFVDAKEKRLKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCW 160
Cdd:cd19346  107 RGRSHDERGEFDWGGCSDNINYGIKFAKAFVDAKEKKEKDARALMNLHNNRCGRMAVKRFMKLECKCHGVSGSCTLRTCW 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901 161 RALSDFRRTGDYLRRRYDGAVQVMATQDGANFTAARQGYRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKTSKGT 240
Cdd:cd19346  187 LAMSDFRKTGDYLRKRYNGAVQVTMNQDGTGFTVANKNFRKATKTDLVYFENSPDYCVMDKSAGSLGTAGRVCNKSSRGT 266

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 630044901 241 DGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCK 288
Cdd:cd19346  267 DGCEVMCCGRGYDTTRVTRVTKCECKFHWCCAVRCKECEETVDVHTCK 314
Wnt_Wnt2_like cd19334
Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and ...
 1-288 0e+00

Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and Wnt-2b. Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381708  Cd Length: 314  Bit Score: 536.15  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901   1 MRSVGEGAREWIRECQHQFRHHRWNCTTLDRDHTVFGRVMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDPYT 80
Cdd:cd19334   27 MVSIGEGAKLGVKECQYQFRNQRWNCSTVDRDATVFGKVLLKGSREAAFVYAISSAGVVHAITRACSKGELLNCACDPTK 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901  81 RGRHHDQRGDFDWGGCSDNIHYGVRFAKAFVDAKEKRLKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCW 160
Cdd:cd19334  107 RGKGRDSKGEFDWGGCSDNVKYGINFARKFVDARERRVRDARALMNLHNNRAGRKAVKKNLKLQCKCHGVSGSCTIRTCW 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901 161 RALSDFRRTGDYLRRRYDGAVQVMATQDGANFTAARQGYRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKTSKGT 240
Cdd:cd19334  187 RALAEFREVGDYLREKYDGAVQVTMNQSGTNLLAANKGHKKPTRSDLVYFESSPDYCVPNPETGSLGTAGRVCNKTSTGT 266

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 630044901 241 DGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCK 288
Cdd:cd19334  267 DGCDIMCCGRGYDTTRVRRTTKCNCKFHWCCQVKCKTCTETVDVHTCK 314
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 1-288 1.72e-171

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 476.66  E-value: 1.72e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901    1 MRSVGEGAREWIRECQHQFRHHRWNCTTLDRDHTVFGRVMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDPyT 80
Cdd:pfam00110  20 MASVAEGAQLAIEECQHQFRNRRWNCSTLENKRPVFGKVLKRGTRETAFVYAISSAGVTHAVTRACSSGELTSCGCDR-K 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901   81 RGRHHDQRGDFDWGGCSDNIHYGVRFAKAFVDAKEKRLKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCW 160
Cdd:pfam00110  99 KRGKSSGEGGWEWGGCSDNIDYGYKFSRKFVDAREKKRRDARALMNLHNNEAGRKAVKSNMRTECKCHGVSGSCSVKTCW 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901  161 RALSDFRRTGDYLRRRYDGAVQV-MATQDGANFTAARQGYRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKTSKG 239
Cdd:pfam00110 179 KALPPFREVGDRLKEKYDGAVKVnRRRNKRGRLVPRNSRFKPPTKNDLVYLEKSPDYCERNPKTGSLGTRGRECNKTSSG 258

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 630044901  240 TDGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCK 288
Cdd:pfam00110 259 PDGCDLLCCGRGYNTRTVTVTERCNCKFHWCCYVKCKTCTETVEVYTCK 307
Wnt_Wnt2 cd19345
Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein ...
 1-288 2.14e-171

Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381719  Cd Length: 314  Bit Score: 477.12  E-value: 2.14e-171
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901   1 MRSVGEGAREWIRECQHQFRHHRWNCTTLDRDHTVFGRVMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDPYT 80
Cdd:cd19345   27 MQAIGSGVKEWIAECQHQFRNHRWNCNTLDRDHSLFGRLLLRSSRESAFVYAISSAGVVFAITRACSQGELKSCSCDPKK 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901  81 RGRHHDQRGDFDWGGCSDNIHYGVRFAKAFVDAKEKRLKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCW 160
Cdd:cd19345  107 KGSSKDSKGSFDWGGCSDNIDYGIRFARAFVDAKERKGKDARALMNLHNNRAGRKAVKRFMTLECKCHGVSGSCTVRTCW 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901 161 RALSDFRRTGDYLRRRYDGAVQVMATQDGANFTAARQGYRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKTSKGT 240
Cdd:cd19345  187 LAMADFRKTGDYLRKKYNGAIQVVMNQDGTGFTVANKHFKKPTKNDLVYFENSPDYCVRDRDAGSLGTAGRVCNRTSRGM 266

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 630044901 241 DGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCK 288
Cdd:cd19345  267 DGCEVMCCGRGYDTSRVGRMTKCECKFHWCCAVRCKDCHQQVDVHTCK 314
WNT1 smart00097
found in Wnt-1;
1-288 2.57e-147

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 415.57  E-value: 2.57e-147
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901     1 MRSVGEGAREWIRECQHQFRHHRWNCTTLDrDHTVFGRVMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDPYT 80
Cdd:smart00097  20 MISVAEGAQEGIEECQHQFRFRRWNCSTLD-NASVFGKVLRQGTRETAFVYAISSAGVAHAVTRACSEGELDSCGCDYRK 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901    81 RGRhhDQRGDFDWGGCSDNIHYGVRFAKAFVDAKEKRlKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCW 160
Cdd:smart00097  99 RGR--AGGRGWKWGGCSDNIDFGIRFSREFVDARERG-KDARALMNLHNNEAGRLAVKKTMKRECKCHGVSGSCTVKTCW 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901   161 RALSDFRRTGDYLRRRYDGAVQVMATQDGANFTAARQG--YRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKTSK 238
Cdd:smart00097 176 LQLPDFRKVGDYLKEKYDGASEVEVDKRGTNKAPVPKNstFKPPTETDLVYLESSPDFCEKNPKTGSLGTQGRQCNKTSK 255

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 630044901   239 GTDGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCK 288
Cdd:smart00097 256 GLDGCDLLCCGRGYNTRTVEVVERCNCKFHWCCYVKCKQCRETVEKHTCK 305
Wnt_Wnt6 cd19338
Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling ...
 1-288 1.72e-144

Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling molecule which affects the development of discrete regions of tissues. It may promote tumorigenesis in gastrointestinal cancer and cervical cancer. It can compensate for the absence of ectoderm and can induce the formation of muscle cells in the limb. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381712  Cd Length: 310  Bit Score: 408.54  E-value: 1.72e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901   1 MRSVGEGAREWIRECQHQFRHHRWNCTTldrDHTVFGRVMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDPYT 80
Cdd:cd19338   28 LEEVAKGAKLGIRECQYQFRNRRWNCST---SRKSFGKILKRDTRETAFVYAITSAGVTYSVTRACSMGELLQCGCDKSK 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901  81 RGRHHDqrGDFDWGGCSDNIHYGVRFAKAFVDAKEKRLKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCW 160
Cdd:cd19338  105 RGKSTE--GEWEWGGCSDNVRYGYRKSREFMDAKEKNRSDIRTLMNLHNNEAGRLAVKNNMRKECKCHGLSGSCTLKTCW 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901 161 RALSDFRRTGDYLRRRYDGAVQVMATQDGANFTAARQGYRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKTSKGT 240
Cdd:cd19338  183 RKMPPFREVGDRLKERFDGAIKVKGSNDGKSLIPEGKTIKPPTKEDLVYLEESPDFCEPNKKTGSLGTRGRECNRTSMGV 262

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 630044901 241 DGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCK 288
Cdd:cd19338  263 DGCDLLCCGRGYQTEVRVVEENCNCRFHWCCEVKCETCKVRKEIHTCN 310
Wnt cd13113
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
 1-287 9.21e-141

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381706  Cd Length: 288  Bit Score: 398.20  E-value: 9.21e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901   1 MRSVGEGAREWIRECQHQFRHHRWNCTTLDrDHTVFGRVMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDpyT 80
Cdd:cd13113    2 MESIAEGAQLALKECQRQFANRRWNCSTFN-EPLLFGKILKRGTRETAFVHAITSAGVTHAITRACSRGKLKNCGCD--R 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901  81 RGRHHDQRGDFDWGGCSDNIHYGVRFAKAFVDAKEKRLK-DARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTC 159
Cdd:cd13113   79 TRQGPEGQGDWTWGGCSDNIKFGIKFSRKFLDAREKKKGsDARSLMNLHNNEAGRKAVKKTMKKKCKCHGVSGSCTTKTC 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901 160 WRALSDFRRTGDYLRRRYDGAVQVM--ATQDGANFTAARQGYRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKTS 237
Cdd:cd13113  159 WRQLPSFREIGDYLKEKYDNAVKVKlnNNGSGLRLVPKRSRFRSPTETDLVYLEESPDYCEPNPTLGSLGTAGRECNPTS 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 630044901 238 KGTDGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTC 287
Cdd:cd13113  239 PGPDSCELLCCGRGYRTETEIVTEKCNCKFVWCCEVKCETCRRTVERYTC 288
Wnt_Wnt5 cd19337
Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a ...
 1-288 8.08e-138

Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a and Wnt-5b, both of which are secreted growth factors that belong to the noncanonical members of the Wingless-related MMTV-integration family. Wnt-5a can activate or inhibit canonical Wnt signaling, depending on receptor context. It specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). The overexpression of Wnt-5b is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381711  Cd Length: 313  Bit Score: 391.99  E-value: 8.08e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901   1 MRSVGEGAREWIRECQHQFRHHRWNCTTLDrDHTVFGRVMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDpyT 80
Cdd:cd19337   22 MPSVGRGAKLAIEECQYQFRYRRWNCSTPD-SSSVFGPVTNIGTREAAFTYAISAAGVVHAIARACREGNLSTCGCS--R 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901  81 RGRHHDQRGDFDWGGCSDNIHYGVRFAKAFVDAKEKRLKD-------ARALMNLHNNRCGRTAVRRFLKLECKCHGVSGS 153
Cdd:cd19337   99 ERRPKDLPRDWLWGGCGDNIEYGYKFAKEFIDARERETNYprhsrelARVLMNLHNNEAGRRAVYEKARVACKCHGVSGS 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901 154 CTLRTCWRALSDFRRTGDYLRRRYDGAVQVMATQDGANFTAARQGYRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVC 233
Cdd:cd19337  179 CSLKTCWRQLAPFREVGDRLKDKYDGAVKVKLNRRGTLLRRRNSRFNKPTKDDLVYLDDSPDYCERNPKTGSLGTKGREC 258

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 630044901 234 SKTSKGTDGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCK 288
Cdd:cd19337  259 NKTSSGTDGCELLCCGRGYNTKKVEVVERCHCKFHWCCEVKCKTCEKIVDVHICK 313
Wnt_Wnt4 cd19336
Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling ...
 1-288 1.24e-134

Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling molecule which affects the development of discrete regions of tissues. Its overexpression may be associated with abnormal proliferation in human breast tissue. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381710  Cd Length: 310  Bit Score: 383.59  E-value: 1.24e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901   1 MRSVGEGAREWIRECQHQFRHHRWNCTTLDRDHtVFGRVMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDPYT 80
Cdd:cd19336   22 MDSVRRGAQLAIEECQFQFRNRRWNCSTLDKEP-VFGKVLNQGTREAAFVHAISSAGVAHAVTRACSSGELEKCGCDRSV 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901  81 RGRHHDQrgdFDWGGCSDNIHYGVRFAKAFVDAKEKR---LKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLR 157
Cdd:cd19336  101 RGRSPEG---FQWSGCSDNVAYGVAFSKSFVDARERRkgrASSSRALMNLHNNEAGRKAIEKNMRVECKCHGVSGSCELK 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901 158 TCWRALSDFRRTGDYLRRRYDGAVQVMATQDGANFTAAR--QGYRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCSK 235
Cdd:cd19336  178 TCWRAMPTFREVGNILKEKFDGATEVQQKRIGSRPVLVPknPQFKPHTDADLVYLDSSPDFCEPDPKTGSLGTHGRVCNK 257

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 630044901 236 TSKGTDGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCK 288
Cdd:cd19336  258 TSKAIDGCDLLCCGRGYVTRTEEVVERCSCKFHWCCYVKCKTCRREVEVHTCR 310
Wnt_Wnt7 cd19339
Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a ...
 1-288 3.12e-132

Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a and Wnt-7b. Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development, and urogenital tract development. Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381713  Cd Length: 313  Bit Score: 377.78  E-value: 3.12e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901   1 MRSVGEGAREWIRECQHQFRHHRWNCTTLDrDHTVFGRVMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDPYT 80
Cdd:cd19339   23 IVAIGEGAQLGIEECQFQFRNHRWNCTLLG-ERTVFGQELPVGSREAAFTYAITSAGVAYAITQACSQGNLSDCGCDKSK 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901  81 RGRHHDQRGdFDWGGCSDNIHYGVRFAKAFVDAKEKRlKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCW 160
Cdd:cd19339  102 KGYGKSDEG-WKWGGCSADVKYGLRFSRKFVDAREVK-RNARSLMNLHNNEAGRKAVEENLKLECKCHGVSGSCTTKTCW 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901 161 RALSDFRRTGDYLRRRYDGAVQVMAT----QDGANFTA--ARQGYRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCS 234
Cdd:cd19339  180 TTLPSFREIGDYLKKKYERARRVEPVrgrrRRRPTFLKlkISRKYKKPRPRDLVYLEKSPNYCEKDPLTGSLGTVGRRCN 259

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 630044901 235 KTSKGTDGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCK 288
Cdd:cd19339  260 RTSTGTDGCDLMCCGRGYNTHQYTKTWQCNCKFHWCCYVKCNTCSERTEEYTCK 313
Wnt_Wnt16 cd19344
Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and ...
 1-288 4.39e-127

Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and noncanonical Wnt ligand involved in the regulation of postnatal bone homeostasis. It promotes bone formation and inhibits bone resorption. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381718  Cd Length: 306  Bit Score: 364.25  E-value: 4.39e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901   1 MRSVGEGAREWIRECQHQFRHHRWNCTTlDRDHTVFGRVMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDPYT 80
Cdd:cd19344   16 IPSVSEGARLGIYECQHQFRHERWNCST-TNDQNVFGKTLSRGTKETAFIYAITSAGVVHAVTRACSAGNLTDCSCDSRR 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901  81 RGRHHDQRgdFDWGGCSDNIHYGVRFAKAFVDAKEK----RLKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTL 156
Cdd:cd19344   95 QGQSASEG--WKWGGCSDNVDYGIWFARKFVDAPEKserkRSRDVRSLMNLHNNEVGRQAIARLMKVKCRCHGVSGSCEV 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901 157 RTCWRALSDFRRTGDYLRRRYDGAVQVMATQDGANFTAARQGYRRA--TRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCS 234
Cdd:cd19344  173 KTCWKTMPSFEEVGDFLKQKYENSIQIATKKSKRRLRRRERRKRKVpiSKDELVYIHKSPNYCVRDPKKGILGTSGRECN 252

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 630044901 235 KTSKGTDGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCK 288
Cdd:cd19344  253 RTSTGPDSCDLLCCGRGYNTQVVRHVERCNCKFVWCCYVKCKTCETMTDVHTCK 306
Wnt_Wnt3_Wnt3a cd19335
Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called ...
 1-288 1.96e-124

Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called proto-oncogene Int-4, functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It is required for normal embryonic development, and especially for limb development. Wnt-3a functions in the canonical Wnt signaling pathway and plays crucial roles in both proliferation and differentiation processes in several types of stem cells. Wnt3a stimulates the migration and invasion of trophoblasts and induce the survival, proliferation, and migration of human embryonic kidney (HEK) 293 cells. It also up-regulates genes implicated in melanocyte differentiation and increases the expression and nuclear localization of the transcriptional co-activator with PDZ-binding motif (TAZ), a transcriptional modulator involved in activating osteoblastic differentiation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381709  Cd Length: 314  Bit Score: 357.86  E-value: 1.96e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901   1 MRSVGEGAREWIRECQHQFRHHRWNCTTLDRDHTVFGRVMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDpyt 80
Cdd:cd19335   25 MPSVAEGAKLGIQECQHQFRGRRWNCTTIEGDLSVFGPVLDKASRESAFVHAIASAGVAHAVTRACAEGDSTSCGCD--- 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901  81 rGRHHDQRGD-FDWGGCSDNIHYGVRFAKAFVDAKEKRlKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTC 159
Cdd:cd19335  102 -SRHKGPPGEgWRWGGCSEDVEFGVRFSREFADARENR-PDARSAMNRHNNEAGRQAILDNMELKCKCHGLSGSCELKTC 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901 160 WRALSDFRRTGDYLRRRYDGAVQVMATQDGANFTAARQ------GYRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVC 233
Cdd:cd19335  180 WWAQPDFRKIGDYLKDKYDSASEMVVERHRESRGWVETlrpkykLFKPPTERDLIYYEESPNFCEPNPETGSFGTRGREC 259

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 630044901 234 SKTSKGTDGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCK 288
Cdd:cd19335  260 NVTSHGIDGCDLLCCGRGYNTRTEKRTEKCHCIFVWCCYVSCQECIRVYDVHTCK 314
Wnt_Wnt11 cd19343
Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule ...
 1-288 7.86e-124

Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule which has possible roles in the development of skeleton, kidney and lung. It is a positive regulator of the Wnt signaling pathway, which plays a crucial role in carcinogenesis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381717  Cd Length: 305  Bit Score: 356.18  E-value: 7.86e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901   1 MRSVGEGAREWIRECQHQFRHHRWNCTTLDRDHTvFGRVMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDPYT 80
Cdd:cd19343   16 MPSVVEAARLTVDTCQEQFADRRWNCSSIELAPN-FTPDLTRGTREQAFVYALSSAALTHTIARACASGALPGCGCGRLP 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901  81 RgrhHDQRGDFDWGGCSDNIHYGVRFAKAFVDAKEKR----LKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTL 156
Cdd:cd19343   95 R---EPPDGDFKWGGCGDNVRYGLRFAKRFTDAPEKKkkkkKRQARALMNLHNNRVGRKAVRDSLETQCKCHGVSGSCSV 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901 157 RTCWRALSDFRRTGDYLRRRYDGAVQVMATQDG--ANFTAARQGYRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCS 234
Cdd:cd19343  172 KTCWKALPDLSEVASRLKRKYARAVEVVSRKVGsrRKLVPKSLKVRPYTKDDLIYLTKSPDYCLPDEKLGSLGTRGRECN 251

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 630044901 235 KTSKGTDGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCK 288
Cdd:cd19343  252 KTSVGSDSCDSMCCGRGYRTYTVEVVERCHCKYHWCCYVKCKTCRRTVEVHVCK 305
Wnt_Wnt10 cd19342
Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein ...
 6-288 3.36e-119

Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein Wnt-10a and Wnt-10b. Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency, and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381716  Cd Length: 316  Bit Score: 344.63  E-value: 3.36e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901   6 EGAREWIRECQHQFRHHRWNCTTLDRDHTV-FGRVML-RSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDPyTRGR 83
Cdd:cd19342   30 QGIQLAVHECQRQFRDHRWNCSSLETKNKNpHTSPILsRGYRETAFAYAISAAGVAHQVARACSLGKLLSCGCDR-SRRG 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901  84 HHDQRGDFDWGGCSDNIHYGVRFAKAFVDAKEKRlKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCWRAL 163
Cdd:cd19342  109 KRSSGNDWKWGGCSHNLDFGEKFSRKFLDSREKA-RDIHSRMNLHNNRAGRLAVSENMERKCKCHGMSGSCELKTCWKAA 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901 164 SDFRRTGDYLRRRYDGAVQVMATQDGANFTAARQGYRRATR----TDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKTSKG 239
Cdd:cd19342  188 PDFREVGDILKEKYDHATLVDQSNLNNGARRRRLTRRKRRRrppkTDLVYYERSPNFCEADPSLDSPGTRGRVCNKTSTG 267

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 630044901 240 TDGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCK 288
Cdd:cd19342  268 PDSCDSLCCGRGYNTVRQTRTERCNCRFHWCCYVVCEKCTETEWVTVCK 316
Wnt_Wnt1 cd19333
Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called ...
 1-287 1.19e-118

Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called proto-oncogene Int-1, acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. It plays a role in osteoblast function, bone development and bone homeostasis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381707  Cd Length: 311  Bit Score: 343.18  E-value: 1.19e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901   1 MRSVGEGAREWIRECQHQFRHHRWNCTTLDRDH--TVFGRVMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDP 78
Cdd:cd19333   16 LHAIARGARMAIKECKWQFRNRRWNCPTTDSRGgpNVFGKILNRGCRETAFIYAITSAAVTHSVARACSEGSIESCSCDY 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901  79 YTRGrhhDQRGDFDWGGCSDNIHYGVRFAKAFVDAKEKRlKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRT 158
Cdd:cd19333   96 RRRG---PGGPDWEWGGCSDNIDFGRKFSREFVDAGEKG-RDLRYLMNLHNNEAGRVHVSSEMRQECKCHGMSGSCTVKT 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901 159 CWRALSDFRRTGDYLRRRYDGAVQVMATQDGANFTAARQG----------YRRATRTDLVYFDNSPDYCVLDKAAGSLGT 228
Cdd:cd19333  172 CWMRLPTFRTVGDRLKDRFDGASRVAYGNNGNNRGSRRAKkfllepenpnHKPPTSKDLVYFEESPNFCEKNPKLGTLGT 251

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 630044901 229 AGRVCSKTSKGTDGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTC 287
Cdd:cd19333  252 RGRECNATSIGLDGCDLMCCGRGYRTETEEVKERCNCTFHWCCEVKCENCTRTRTVHTC 310
Wnt_Wnt5a cd19347
Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor ...
 1-288 6.61e-114

Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. It can activate or inhibit canonical Wnt signaling, depending on receptor context. Wnt-5a specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381721  Cd Length: 312  Bit Score: 331.26  E-value: 6.61e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901   1 MRSVGEGAREWIRECQHQFRHHRWNCTTLDrDHTVFGRVMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDpyT 80
Cdd:cd19347   22 MQYIGEGAKTGIKECQYQFRHRRWNCSTVD-NTSVFGRVMQIGSRETAFTYAISAAGVVNAVSRACREGELSTCGCS--R 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901  81 RGRHHDQRGDFDWGGCSDNIHYGVRFAKAFVDAKEKR-------LKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGS 153
Cdd:cd19347   99 AARPKDLPRDWLWGGCGDNLEYGYRFAKEFVDAREREkiyqkgsYESARTLMNLHNNEAGRRTVYNLADVACKCHGVSGS 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901 154 CTLRTCWRALSDFRRTGDYLRRRYDGAVQVMATQDGaNFTAARQGYRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVC 233
Cdd:cd19347  179 CSLKTCWLQLADFRKVGDALKEKYDSAAAMKLNSRG-KLVQVNSRFNPPTTLDLVYIDPSPDYCVRNESTGSLGTQGRLC 257

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 630044901 234 SKTSKGTDGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCK 288
Cdd:cd19347  258 NKTSEGMDGCELMCCGRGYDQFKTVQTERCHCKFHWCCYVKCKKCTEIVDQFVCK 312
Wnt_Wnt5b cd19348
Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor ...
 1-288 2.06e-111

Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. Its overexpression is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381722  Cd Length: 312  Bit Score: 325.01  E-value: 2.06e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901   1 MRSVGEGAREWIRECQHQFRHHRWNCTTLDrDHTVFGRVMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDPYT 80
Cdd:cd19348   22 MVYIGEGAKTGIKECQYQFRQRRWNCSTVD-NTSVFGRVMQIGSRETAFTYAVSAAGVVNAISRACREGELSTCGCSRAA 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901  81 RGRhhDQRGDFDWGGCSDNIHYGVRFAKAFVDAKEKR-------LKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGS 153
Cdd:cd19348  101 RPK--DLPRDWLWGGCGDNVEYGYRFAKEFVDAREREknypkgsEEHARTLMNLQNNEAGRRAVYNLADVACKCHGVSGS 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901 154 CTLRTCWRALSDFRRTGDYLRRRYDGAVQVMATQDGaNFTAARQGYRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVC 233
Cdd:cd19348  179 CSLKTCWLQLADFRKVGDLLKEKYDSAAAMRINRKG-KLELVNSRFNPPTAEDLVYIDPSPDYCLRNETTGSLGTQGRLC 257

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 630044901 234 SKTSKGTDGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCK 288
Cdd:cd19348  258 NKTSEGMDGCELMCCGRGYDQFKTVQVERCHCKFHWCCYVKCKKCTEIVDQFVCK 312
Wnt_Wnt7a cd19349
Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand ...
 4-288 2.40e-108

Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381723  Cd Length: 318  Bit Score: 317.38  E-value: 2.40e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901   4 VGEGAREWIRECQHQFRHHRWNCTTLDrDHTVFGRVMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDPYTRGR 83
Cdd:cd19349   31 IGEGAQMGINECQFQFRNGRWNCSALG-ERTVFGKELKVGSREAAFTYAIIAAGVAHAITAACTQGNLSDCGCDKEKQGQ 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901  84 HHDQRGdFDWGGCSDNIHYGVRFAKAFVDAKEKRlKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCWRAL 163
Cdd:cd19349  110 YNQEEG-WKWGGCSADIRYGIGFSKVFVDAREIK-QNARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901 164 SDFRRTGDYLRRRYDGAVQVMATQDGAN----FTAARQ--GYRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKTS 237
Cdd:cd19349  188 PKFRELGYILKDKYNEAVHVEPVRASRNkrptFLKIKKplSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRMCNKTA 267

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 630044901 238 KGTDGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCK 288
Cdd:cd19349  268 QQNNGCDLMCCGRGYNTHQYSRVWQCNCKFHWCCYVKCNTCSERTEVYTCK 318
Wnt_Wnt8 cd19340
Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a ...
 1-287 1.13e-100

Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a and Wnt-8b. Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381714  Cd Length: 301  Bit Score: 297.28  E-value: 1.13e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901   1 MRSVGEGAREWIRECQHQFRHHRWNCTTLDRDHTvfgRVMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDPYT 80
Cdd:cd19340   10 SDSVAAGAQLAMEECQYQFKWDRWNCPESAFFSQ---KNNPSATRETAFVHAISSAGVMYTLTRNCSLGHFEGCGCDDSK 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901  81 RGRHHDQrgDFDWGGCSDNIHYGVRFAKAFVDAKEKRlKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCW 160
Cdd:cd19340   87 KGSKGGE--GWTWGGCSDNVKFGERVSKKFLDSLETG-QDAQALMNLHNNRAGRKAVRKTMKKTCKCHGVSGSCSTQTCW 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901 161 RALSDFRRTGDYLRRRYDGAVQVMATQDGANFT--AARQGYRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKTSK 238
Cdd:cd19340  164 MQLAPFREIGTDLKRKYDRAVRVDYENGGLRETngSRAIKLLNIKKNDLVYLEKSPNYCRANVTLGWPGTLGRQCSRDKK 243

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 630044901 239 -GTDGCEIMCCGR-----GYD--TTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTC 287
Cdd:cd19340  244 eSVSRWERKSCRRlcracGLKvrKKVVEVTSSCNCKFHWCCEVKCETCVELVIEYTC 300
wnt_Wnt7b cd19350
Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt ...
 4-288 6.61e-100

Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381724  Cd Length: 318  Bit Score: 295.77  E-value: 6.61e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901   4 VGEGAREWIRECQHQFRHHRWNCTTLDrDHTVFGRVMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDPYTRGR 83
Cdd:cd19350   31 IGEGAQMGINECQYQFRYGRWNCSALG-ERTVFGQELRVGSREAAFTYAITAAGVAHAVTAACSQGNLSNCGCDREKQGY 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901  84 HHDQRGdFDWGGCSDNIHYGVRFAKAFVDAKEKRlKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCWRAL 163
Cdd:cd19350  110 YNQEEG-WKWGGCSADIKYGIDFSRKFVDAREIK-KNARRLMNLHNNEAGRKVLEERMKLECKCHGVSGSCTTKTCWTTL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901 164 SDFRRTGDYLRRRYDGAVQVMAT------QDGANFTAARQGYRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKTS 237
Cdd:cd19350  188 PKFREIGYVLKEKYNAAVQVEVVrasrlrQPTFLKIKKRRSYQKPMETDLVYIERSPNYCEEDAATGSVGTQGRLCNRTS 267

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 630044901 238 KGTDGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCK 288
Cdd:cd19350  268 PHTDGCDLMCCGRGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTEVFTCK 318
Wnt_Wnt9 cd19341
Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a ...
 6-288 4.80e-95

Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a and Wnt-9b, both of which function in the canonical Wnt/beta-catenin signaling pathway. Wnt-9a, also called protein Wnt-14, is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt-9b, also called protein Wnt-14b, or protein Wnt-15, plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381715  Cd Length: 299  Bit Score: 282.64  E-value: 4.80e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901   6 EGAREWIRECQHQFRHHRWNCTTLDRDHTVFGRVMlrssREAAFVYAISSAGVVHAITRACSQGELSVCSCDPYTRGRhh 85
Cdd:cd19341   21 EAIRLSVLECQEQFRYERWNCSLGKYRINLLKKGY----KETAFLYAISSAGLTHSVARACSSGRLDRCTCDESFSLE-- 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901  86 DQRGDFDWGGCSDNIHYGVRFAKAFVDAKEKRLKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCWRALSD 165
Cdd:cd19341   95 ENRQTWLWGGCGDNIKYGKKFTRRFLQLKKKSGKDLRAEIDRHNSEVGIRVVREGVKKTCKCHGVSGSCTVKTCWKQLAP 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901 166 FRRTGDYLRRRYDGAVQVMATQDGANFTAARQGYRRAT--------RTDLVYFDNSPDYCVLDKAagSLGTAGRVCSKts 237
Cdd:cd19341  175 FNEIGKILKRKYEKAVKVVSENNAATGGSQLRKGKSGSvkkksrprRKDLVYLEKSPSFCRSTRY--SPGTKGRRCLK-- 250

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 630044901 238 kgTDGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCK 288
Cdd:cd19341  251 --GDNCDTLCCGRGYNTQSEVVVKPCKCRVVWCCQVECKTCTEREEIYTCK 299
Wnt_Wnt10a cd19355
Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ...
 3-288 1.21e-88

Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381729  Cd Length: 302  Bit Score: 266.46  E-value: 1.21e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901   3 SVGEGAREWIRECQHQFRHHRWNCTTLDRDHTV--FGRVMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDpyt 80
Cdd:cd19355   27 SAIQGIQIAIHECQHQFRDHRWNCSSLETRNKIpyESVVFSRGFRESAFAYAIAAAGVVHAVSNACAMGKLKACGCD--- 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901  81 rgrhhdqrgdFDWGGCSDNIHYGVRFAKAFVDAKEKrLKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCW 160
Cdd:cd19355  104 ----------WEWGGCSPDVEYGERFSKDFLDSRET-YRDIHARMRLHNNRVGRQVVMDNMRRKCKCHGTSGSCQLKTCW 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901 161 RALSDFRRTGDYLRRRYDGAVQVMA-TQDGANFTAARQGYRR-ATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKTSK 238
Cdd:cd19355  173 QVTPEFRTVGSLLKDRFYVATLIKPhNRNTGQLEPGHAPHRRrASINDLVYFEKSPDFCEREPRLDSAGTQGRICNKTSP 252

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 630044901 239 GTDGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCK 288
Cdd:cd19355  253 GMDNCESLCCGRGHNILRQTRSERCNCKFHWCCYVVCEECRITEWVSVCK 302
Wnt_Wnt8a cd19351
Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, ...
 3-287 8.51e-78

Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381725  Cd Length: 307  Bit Score: 239.03  E-value: 8.51e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901   3 SVGEGAREWIRECQHQFRHHRWNCTTLDRDHTVFGRvmLRS-SREAAFVYAISSAGVVHAITRACSQGELSVCSCDPYTR 81
Cdd:cd19351   12 SVAAGAQSGIEECKHQFAWERWNCPESALQLSTHNG--LRSaTRETSFVHAISSAGVMYTLTRNCSLGDFENCGCDDSRN 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901  82 GRHhDQRGdFDWGGCSDNIHYGVRFAKAFVDAKEKRlKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCWR 161
Cdd:cd19351   90 GRT-GGRG-WIWGGCSDNVEFGERISKQFVDALETG-QDARALMNLHNNEAGRLAVKATMKRTCKCHGVSGSCSIQTCWL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901 162 ALSDFRRTGDYLRRRYDGAV-------QVMATQDGANFTAARQGYRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCS 234
Cdd:cd19351  167 QLADFREIGNYLKVKHDQALklemdkrRMRAGNSADNRGAIAEAFGSVAETELIYLEDSPDYCTKNASLGLQGTEGRECL 246

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901 235 KTSKGTD-----GCEIMC--CGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTC 287
Cdd:cd19351  247 QSGKNLSqwerrSCRRLCteCGLRVEERRTEVVSSCNCKFHWCCTVKCEQCRQVVTKHYC 306
Wnt_Wnt9b cd19354
Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b ...
 6-288 2.92e-77

Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b or Wnt-15, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381728  Cd Length: 297  Bit Score: 237.49  E-value: 2.92e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901   6 EGAREWIR----ECQHQFRHHRWNCTTLDRdhtvfGRVMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDPYTR 81
Cdd:cd19354   17 ETLRDAVRlgllECQFQFRSERWNCSLEGR-----GSLLKRGFKETAFLYAVSSAALTHSLAKACSSGRMERCTCDDSPG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901  82 GRHhdqRGDFDWGGCSDNIHYGVRFAKAFVDAKeKRLKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCWR 161
Cdd:cd19354   92 LEN---REAWQWGVCGDNLKYSTKFLKNFLGQK-KGSKDLRARVDAHNTNVGIKAVKSGLKTTCKCHGVSGSCAVRTCWK 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901 162 ALSDFRRTGDYLRRRYDGAVQVMATQDGAN-----FTAARQGYRRATR----TDLVYFDNSPDYCVLDKAagSLGTAGRV 232
Cdd:cd19354  168 QLSPFHETGRLLKLKYENAVKVHSVTNDATgetelWSPERHGHTLKGHsprsTDLVYLEDSPSFCRPSKY--SPGTAGRT 245

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 630044901 233 CSKTSKgtdgCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCK 288
Cdd:cd19354  246 CSRETN----CDSLCCGRGYNTQSRLVTFSCHCQVQWCCYVECQQCVQEEEVYTCK 297
Wnt_Wnt10b cd19356
Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, ...
 12-288 9.07e-77

Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381730  Cd Length: 299  Bit Score: 236.32  E-value: 9.07e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901  12 IRECQHQFRHHRWNCTTLDRDHTVF--GRVMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDpytrgrhhdqrg 89
Cdd:cd19356   36 IHECQHQLRDQRWNCSSLEGGGKLPhdSAILKRGFRESAFSFSLLAAGVMHSVATACSLGKLRGCGCE------------ 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901  90 dFDWGGCSDNIHYGVRFAKAFVDAKEKRlKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCWRALSDFRRT 169
Cdd:cd19356  104 -WEWGGCSHDIEFGEKFSRDFLDSRESP-RDIQARMRIHNNRVGRQVVTENMKRKCKCHGTSGSCQFKTCWHVTPEFRLV 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901 170 GDYLRRRYDGAVQVMATQDGANFTAARQGYRRATRtDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKTSKGTDGCEIMCCG 249
Cdd:cd19356  182 GALLREKFQRAIFINSHNKNSGVFLPRLRPRRLAR-ELVYFEKSPDFCERDPAVDSPGTQGRICNKTSPGMDGCGSLCCG 260

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 630044901 250 RGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCK 288
Cdd:cd19356  261 RGHNILKQTRSERCHCRFHWCCYVLCEECRVTEWVNVCK 299
Wnt_Wnt8b cd19352
Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in ...
 3-287 3.27e-75

Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381726  Cd Length: 305  Bit Score: 232.61  E-value: 3.27e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901   3 SVGEGAREWIRECQHQFRHHRWNCTtlDRDHTVFGRVMLRSS-REAAFVYAISSAGVVHAITRACSQGELSVCSCDPYTR 81
Cdd:cd19352   13 SVAAGAQSGIEECKYQFAWDRWNCP--ERALQLSSHSGLRSAnRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRN 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901  82 GRHHDQrgDFDWGGCSDNIHYGVRFAKAFVDAKEKRlKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCWR 161
Cdd:cd19352   91 GQLGGQ--GWLWGGCSDNVGFGEAISKQFVDALETG-QDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901 162 ALSDFRRTGDYLRRRYDGAVQVMATQDGANFTAAR----QGYRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKTS 237
Cdd:cd19352  168 QLPEFREVGNYLKEKYHRALKVDLLQGAGNSAASRgaiaETFRSISKKELVHLEDSPDYCLENKTLGLLGTEGRECLKRG 247

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 630044901 238 KGTD-----GCEIMC--CGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTC 287
Cdd:cd19352  248 KALSkwekrSCRRLCgdCGLAVEERRAEMVSSCNCKFHWCCAVKCEQCRKTVTKYFC 304
Wnt_Wnt9a cd19353
Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, ...
 14-288 1.52e-69

Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, functions in the canonical Wnt/beta-catenin signaling pathway. It is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381727  Cd Length: 298  Bit Score: 217.60  E-value: 1.52e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901  14 ECQHQFRHHRWNCTTLDRDHtvfGRVMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDpytRGRHHDQRGDFDW 93
Cdd:cd19353   29 ECQYQFRFERWNCTLEGRYR---ASLLKRGFKETAFLYAISSAGLTHAMAKACSAGRMERCTCD---EAPDLENREAWQW 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901  94 GGCSDNIHYGVRFAKAFVDAKEKrlKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCWRALSDFRRTGDYL 173
Cdd:cd19353  103 GGCGDNLKYSNKFVKEFLGRKSS--KDLRARVDFHNNLVGIKVIKAGVETTCKCHGVSGSCTVRTCWRQLSPFHEIGKQL 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 630044901 174 RRRYDGAVQVMATQDGANFTAARQGYRRAT---------RTDLVYFDNSPDYCVLDKAagSLGTAGRVCSKTSKgtdgCE 244
Cdd:cd19353  181 KQKYETSLKVGSTTNEATGEGDISPPKKSGaghsdqiprTTDLVYIDDSPSFCLMSRF--SPGTSGRRCYKDKN----CE 254

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 630044901 245 IMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCK 288
Cdd:cd19353  255 SICCGRGHNTQSRVVTRPCQCQVRWCCYVECKQCTQREEVYTCK 298
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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