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Conserved domains on  [gi|631790829|ref|NP_001278831|]
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low-density lipoprotein receptor-related protein 5 isoform 2 [Homo sapiens]

Protein Classification

LY and LDLa domain-containing protein( domain architecture ID 11235746)

protein containing domains NHL, LY, FXa_inhibition, and LDLa

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 129-171 1.69e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 1.69e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 631790829    129 EHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFR 171
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
677-714 5.66e-11

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.03  E-value: 5.66e-11
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 631790829   677 TCSPDQFACATGEidCIPGAWRCDGFPECDDQSDEEGC 714
Cdd:pfam00057    2 TCSPNEFQCGSGE--CIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 755-789 6.24e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.99  E-value: 6.24e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 631790829  755 CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 789
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 717-751 1.71e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.83  E-value: 1.71e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 631790829  717 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADC 751
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 325-360 3.64e-10

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 55.71  E-value: 3.64e-10
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 631790829   325 CMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNC 360
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 172-215 1.95e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.06  E-value: 1.95e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 631790829    172 QVLVWRDLDNPRSLALDPTKGYIYWTEWgGKPRIVRAFMDGTNC 215
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDW-GLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 24-59 3.65e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 49.93  E-value: 3.65e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 631790829    24 CADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTC 59
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 104-297 4.39e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd05819:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 269  Bit Score: 55.79  E-value: 4.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 631790829  104 SNNHIYWTDVSLKTISR-----AFMNGSSVEHVVEFGLDYPEGMAVDwMGKNLYWADTGTNRIEVARLDGQFRQVLV--- 175
Cdd:cd05819    17 SSGNIYVADTGNNRIQVfdpdgNFITSFGSFGSGDGQFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASFGgsg 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 631790829  176 --WRDLDNPRSLALDPtKGYIYWTEWGGKpRIVRaFMDGTNCMTLVDKVGRAN-------DLTIDyADQRLYWTDLDTNM 246
Cdd:cd05819    96 dgDGEFNGPRGIAVDS-SGNIYVADTGNH-RIQK-FDPDGEFLTTFGSGGSGPgqfngptGVAVD-SDGNIYVADTGNHR 171

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 631790829  247 IE----SSNML---GQERVVIAdDLPHPFGLT-QYSDYIYWTDWNLHSIERADKTSGRN 297
Cdd:cd05819   172 IQvfdpDGNFLttfGSTGTGPG-QFNYPTGIAvDSDGNIYVADSGNNRVQVFDPDGAGF 229
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 523-565 3.22e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.60  E-value: 3.22e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 631790829    523 EVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANR 565
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 636-672 5.25e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.16  E-value: 5.25e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 631790829   636 CARDNGGCSHICIAKGDGTpRCSCPVHLVLLQNLLTC 672
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGY-TCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 389-428 1.58e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.89  E-value: 1.58e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 631790829    389 ILPLHGLRNVKAIDYDPLDKFIYWVD-GRQNIKRAKDDGTQ 428
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDwGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 479-522 6.26e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.35  E-value: 6.26e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 631790829    479 VVLRGDRDKPRAIVVNAERGYLYFTNMqdRAAKIERAALDGTER 522
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDW--GLDVIEVANLDGTNR 43
 
Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 129-171 1.69e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 1.69e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 631790829    129 EHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFR 171
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
677-714 5.66e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.03  E-value: 5.66e-11
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 631790829   677 TCSPDQFACATGEidCIPGAWRCDGFPECDDQSDEEGC 714
Cdd:pfam00057    2 TCSPNEFQCGSGE--CIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 755-789 6.24e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.99  E-value: 6.24e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 631790829  755 CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 789
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 678-714 1.46e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.83  E-value: 1.46e-10
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 631790829  678 CSPDQFACATGEidCIPGAWRCDGFPECDDQSDEEGC 714
Cdd:cd00112     1 CPPNEFRCANGR--CIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 717-751 1.71e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.83  E-value: 1.71e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 631790829  717 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADC 751
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 325-360 3.64e-10

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 55.71  E-value: 3.64e-10
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 631790829   325 CMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNC 360
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 677-711 1.39e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.18  E-value: 1.39e-09
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 631790829    677 TCSPDQFACATGEidCIPGAWRCDGFPECDDQSDE 711
Cdd:smart00192    1 TCPPGEFQCDNGR--CIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
717-751 4.02e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.02  E-value: 4.02e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 631790829   717 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADC 751
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 755-786 6.32e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.25  E-value: 6.32e-09
                            10        20        30
                    ....*....|....*....|....*....|..
gi 631790829    755 CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDE 786
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
755-789 1.81e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.10  E-value: 1.81e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 631790829   755 CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 789
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 172-215 1.95e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.06  E-value: 1.95e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 631790829    172 QVLVWRDLDNPRSLALDPTKGYIYWTEWgGKPRIVRAFMDGTNC 215
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDW-GLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 24-59 3.65e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 49.93  E-value: 3.65e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 631790829    24 CADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTC 59
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
67-201 4.21e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 55.09  E-value: 4.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 631790829   67 VFTSRAAIHRIS-LETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGlDYPEGMAVD 145
Cdd:COG3391    82 LYVANSGSGRVSvIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVG-AGPHGIAVD 160

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 631790829  146 WMGKNLYWADTGTNRIE--VARLDGQFRQVL-VWRDLDNPRSLALDPTKGYIYWTEWGG 201
Cdd:COG3391   161 PDGKRLYVANSGSNTVSviVSVIDTATGKVVaTIPVGGGPVGVAVSPDGRRLYVANRGS 219
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 104-297 4.39e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 55.79  E-value: 4.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 631790829  104 SNNHIYWTDVSLKTISR-----AFMNGSSVEHVVEFGLDYPEGMAVDwMGKNLYWADTGTNRIEVARLDGQFRQVLV--- 175
Cdd:cd05819    17 SSGNIYVADTGNNRIQVfdpdgNFITSFGSFGSGDGQFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASFGgsg 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 631790829  176 --WRDLDNPRSLALDPtKGYIYWTEWGGKpRIVRaFMDGTNCMTLVDKVGRAN-------DLTIDyADQRLYWTDLDTNM 246
Cdd:cd05819    96 dgDGEFNGPRGIAVDS-SGNIYVADTGNH-RIQK-FDPDGEFLTTFGSGGSGPgqfngptGVAVD-SDGNIYVADTGNHR 171

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 631790829  247 IE----SSNML---GQERVVIAdDLPHPFGLT-QYSDYIYWTDWNLHSIERADKTSGRN 297
Cdd:cd05819   172 IQvfdpDGNFLttfGSTGTGPG-QFNYPTGIAvDSDGNIYVADSGNNRVQVFDPDGAGF 229
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 717-748 5.03e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.55  E-value: 5.03e-08
                            10        20        30
                    ....*....|....*....|....*....|..
gi 631790829    717 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDE 748
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 523-565 3.22e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.60  E-value: 3.22e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 631790829    523 EVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANR 565
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 218-257 8.09e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.44  E-value: 8.09e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 631790829    218 LVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQER 257
Cdd:smart00135    4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 636-672 5.25e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.16  E-value: 5.25e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 631790829   636 CARDNGGCSHICIAKGDGTpRCSCPVHLVLLQNLLTC 672
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGY-TCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 106-146 7.12e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 43.69  E-value: 7.12e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 631790829   106 NHIYWTDVSLK-TISRAFMNGSSVEHVVEFGLDYPEGMAVDW 146
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
148-247 7.89e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.54  E-value: 7.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 631790829  148 GKNLYWADTGTNRIEVARLDgQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKpRIVRafMDGTNcMTLVDKV---GR 224
Cdd:COG3391    79 GRRLYVANSGSGRVSVIDLA-TGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNG-RVSV--IDTAT-GKVVATIpvgAG 153

                          90       100
                  ....*....|....*....|...
gi 631790829  225 ANDLTIDYADQRLYWTDLDTNMI 247
Cdd:COG3391   154 PHGIAVDPDGKRLYVANSGSNTV 176
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 131-195 1.13e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 47.97  E-value: 1.13e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 631790829  131 VVEF-GLDYPEGMAVDWMGkNLYWADTGTNRieVARLD-GQFRQ-VLVWRDLDNPRSLALDPTkGYIY 195
Cdd:cd14952     3 VLPFtGLDGPGGVAVDAAG-NVYVADSGNNR--VLKLAaGSTTQtVLPFTGLYQPQGVAVDAA-GTVY 66
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 150-189 3.43e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 41.76  E-value: 3.43e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 631790829   150 NLYWADTGT-NRIEVARLDGQFRQVLVWRDLDNPRSLALDP 189
Cdd:pfam00058    2 RLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
672-767 8.08e-05

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 43.98  E-value: 8.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 631790829  672 CGEppTCSPDQfACATGEIDCIPGAWRCDGfpEC-DDQSDEEGCPVCSAAQFP---CARGQCVDL----RLRCDGEadCQ 743
Cdd:NF041328   45 CGV--ACGAGQ-TCVAGACGCGPGTVACGG--ACvDTASDPAHCGACGAACAPgqvCEGGACREAcsegLTRCGGA--CV 117

                          90       100
                  ....*....|....*....|....*...
gi 631790829  744 D-RSDEAD---CDAICLPNQFrCASGQC 767
Cdd:NF041328  118 DlATDPLHcgaCGVACDPGES-CRGGAC 144
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 137-213 1.20e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 44.97  E-value: 1.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 631790829  137 DYPEGMAVDwMGKNLYWADTGTNRIEVARLDGQF-RQvlVWR--DLDN----PRSLALDPtKGYIYWTE-WGGkpRIVRA 208
Cdd:cd14956    13 KDPRGIAVD-ADDNVYVADARNGRIQVFDKDGTFlRR--FGTtgDGPGqfgrPRGLAVDK-DGWLYVADyWGD--RIQVF 86


                  ....*
gi 631790829  209 FMDGT 213
Cdd:cd14956    87 TLTGE 91
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 389-428 1.58e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.89  E-value: 1.58e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 631790829    389 ILPLHGLRNVKAIDYDPLDKFIYWVD-GRQNIKRAKDDGTQ 428
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDwGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 479-522 6.26e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.35  E-value: 6.26e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 631790829    479 VVLRGDRDKPRAIVVNAERGYLYFTNMqdRAAKIERAALDGTER 522
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDW--GLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 192-232 1.02e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.52  E-value: 1.02e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 631790829   192 GYIYWTEWGGKPRIVRAFMDGTNCMTLV-DKVGRANDLTIDY 232
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFtDDLQHPNAIAVDP 42
 
Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 129-171 1.69e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 1.69e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 631790829    129 EHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFR 171
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
677-714 5.66e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.03  E-value: 5.66e-11
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 631790829   677 TCSPDQFACATGEidCIPGAWRCDGFPECDDQSDEEGC 714
Cdd:pfam00057    2 TCSPNEFQCGSGE--CIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 755-789 6.24e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.99  E-value: 6.24e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 631790829  755 CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 789
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 678-714 1.46e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.83  E-value: 1.46e-10
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 631790829  678 CSPDQFACATGEidCIPGAWRCDGFPECDDQSDEEGC 714
Cdd:cd00112     1 CPPNEFRCANGR--CIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 717-751 1.71e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.83  E-value: 1.71e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 631790829  717 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADC 751
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 325-360 3.64e-10

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 55.71  E-value: 3.64e-10
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 631790829   325 CMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNC 360
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 677-711 1.39e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.18  E-value: 1.39e-09
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 631790829    677 TCSPDQFACATGEidCIPGAWRCDGFPECDDQSDE 711
Cdd:smart00192    1 TCPPGEFQCDNGR--CIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
717-751 4.02e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.02  E-value: 4.02e-09
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 631790829   717 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADC 751
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 755-786 6.32e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 52.25  E-value: 6.32e-09
                            10        20        30
                    ....*....|....*....|....*....|..
gi 631790829    755 CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDE 786
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
755-789 1.81e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 51.10  E-value: 1.81e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 631790829   755 CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 789
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 172-215 1.95e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 51.06  E-value: 1.95e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 631790829    172 QVLVWRDLDNPRSLALDPTKGYIYWTEWgGKPRIVRAFMDGTNC 215
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDW-GLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 24-59 3.65e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 49.93  E-value: 3.65e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 631790829    24 CADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTC 59
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
67-201 4.21e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 55.09  E-value: 4.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 631790829   67 VFTSRAAIHRIS-LETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGlDYPEGMAVD 145
Cdd:COG3391    82 LYVANSGSGRVSvIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVG-AGPHGIAVD 160

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 631790829  146 WMGKNLYWADTGTNRIE--VARLDGQFRQVL-VWRDLDNPRSLALDPTKGYIYWTEWGG 201
Cdd:COG3391   161 PDGKRLYVANSGSNTVSviVSVIDTATGKVVaTIPVGGGPVGVAVSPDGRRLYVANRGS 219
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 104-297 4.39e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 55.79  E-value: 4.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 631790829  104 SNNHIYWTDVSLKTISR-----AFMNGSSVEHVVEFGLDYPEGMAVDwMGKNLYWADTGTNRIEVARLDGQFRQVLV--- 175
Cdd:cd05819    17 SSGNIYVADTGNNRIQVfdpdgNFITSFGSFGSGDGQFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASFGgsg 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 631790829  176 --WRDLDNPRSLALDPtKGYIYWTEWGGKpRIVRaFMDGTNCMTLVDKVGRAN-------DLTIDyADQRLYWTDLDTNM 246
Cdd:cd05819    96 dgDGEFNGPRGIAVDS-SGNIYVADTGNH-RIQK-FDPDGEFLTTFGSGGSGPgqfngptGVAVD-SDGNIYVADTGNHR 171

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 631790829  247 IE----SSNML---GQERVVIAdDLPHPFGLT-QYSDYIYWTDWNLHSIERADKTSGRN 297
Cdd:cd05819   172 IQvfdpDGNFLttfGSTGTGPG-QFNYPTGIAvDSDGNIYVADSGNNRVQVFDPDGAGF 229
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 717-748 5.03e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.55  E-value: 5.03e-08
                            10        20        30
                    ....*....|....*....|....*....|..
gi 631790829    717 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDE 748
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 523-565 3.22e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 47.60  E-value: 3.22e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 631790829    523 EVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANR 565
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 218-257 8.09e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.44  E-value: 8.09e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 631790829    218 LVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQER 257
Cdd:smart00135    4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 88-128 1.74e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 45.67  E-value: 1.74e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 631790829     88 IPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSV 128
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 257-298 2.57e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 44.90  E-value: 2.57e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 631790829    257 RVVIADDLPHPFGLT--QYSDYIYWTDWNLHSIERADKTsGRNR 298
Cdd:smart00135    1 RTLLSSGLGHPNGLAvdWIEGRLYWTDWGLDVIEVANLD-GTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 636-672 5.25e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.16  E-value: 5.25e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 631790829   636 CARDNGGCSHICIAKGDGTpRCSCPVHLVLLQNLLTC 672
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGY-TCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 106-146 7.12e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 43.69  E-value: 7.12e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 631790829   106 NHIYWTDVSLK-TISRAFMNGSSVEHVVEFGLDYPEGMAVDW 146
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
148-247 7.89e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.54  E-value: 7.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 631790829  148 GKNLYWADTGTNRIEVARLDgQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKpRIVRafMDGTNcMTLVDKV---GR 224
Cdd:COG3391    79 GRRLYVANSGSGRVSVIDLA-TGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNG-RVSV--IDTAT-GKVVATIpvgAG 153

                          90       100
                  ....*....|....*....|...
gi 631790829  225 ANDLTIDYADQRLYWTDLDTNMI 247
Cdd:COG3391   154 PHGIAVDPDGKRLYVANSGSNTV 176
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
73-247 8.46e-06

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 48.48  E-value: 8.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 631790829   73 AIHRISLETNNND-VAIPlTGVKEASALDFDvSNNHIYWTDVSLKTISR---AfmNGSSVEHVVEFGLDYPEGMAVDWMG 148
Cdd:COG4257    81 RIGRIDPKTGEITtFALP-GGGSNPHGIAFD-PDGNLWFTDQGGNRIGRldpA--TGEVTEFPLPTGGAGPYGIAVDPDG 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 631790829  149 kNLYWADTGTNRIevARLD---GQFRQVLVWRDLDNPRSLALDPtKGYIYWTEWGGkpRIVRAFMDGTNCMT---LVDKV 222
Cdd:COG4257   157 -NLWVTDFGANAI--GRIDpdtGTLTEYALPTPGAGPRGLAVDP-DGNLWVADTGS--GRIGRFDPKTGTVTeypLPGGG 230

                         170       180
                  ....*....|....*....|....*
gi 631790829  223 GRANDLTIDYADqRLYWTDLDTNMI 247
Cdd:COG4257   231 ARPYGVAVDGDG-RVWFAESGANRI 254
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 131-195 1.13e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 47.97  E-value: 1.13e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 631790829  131 VVEF-GLDYPEGMAVDWMGkNLYWADTGTNRieVARLD-GQFRQ-VLVWRDLDNPRSLALDPTkGYIY 195
Cdd:cd14952     3 VLPFtGLDGPGGVAVDAAG-NVYVADSGNNR--VLKLAaGSTTQtVLPFTGLYQPQGVAVDAA-GTVY 66
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 83-207 1.53e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 47.59  E-value: 1.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 631790829   83 NNDVAIPLTGVKEASALDFDVSNNhIYWTD------VSLKTisrafmnGSSVEHVVEF-GLDYPEGMAVDWMGkNLYWAD 155
Cdd:cd14952    83 TTQTVLPFTGLNDPTGVAVDAAGN-VYVADtgnnrvLKLAA-------GSNTQTVLPFtGLSNPDGVAVDGAG-NVYVTD 153

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 631790829  156 TGTNRieVARLD-GQFRQ-VLVWRDLDNPRSLALDpTKGYIYWTEwGGKPRIVR 207
Cdd:cd14952   154 TGNNR--VLKLAaGSTTQtVLPFTGLNSPSGVAVD-TAGNVYVTD-HGNNRVLK 203
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 102-247 1.92e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 47.67  E-value: 1.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 631790829  102 DVSNNHIYWTDVSLKTISRAFMNGssvEHVVEFG--------LDYPEGMAVDWMGkNLYWADTGTNRIEVARLDGQFRQV 173
Cdd:cd14963   108 AIDDGKLYVSDVKKHKVIVFDLEG---KLLLEFGkpgsepgeLSYPNGIAVDEDG-NIYVADSGNGRIQVFDKNGKFIKE 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 631790829  174 LVWRDLD-----NPRSLALDPtKGYIY-----------WTEWGGKPRIVRAFMDGTNCMTLvdkvgrANDLTIDyADQRL 237
Cdd:cd14963   184 LNGSPDGksgfvNPRGIAVDP-DGNLYvvdnlshrvyvFDEQGKELFTFGGRGKDDGQFNL------PNGLFID-DDGRL 255

                         170
                  ....*....|
gi 631790829  238 YWTDLDTNMI 247
Cdd:cd14963   256 YVTDRENNRV 265
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 150-189 3.43e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 41.76  E-value: 3.43e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 631790829   150 NLYWADTGT-NRIEVARLDGQFRQVLVWRDLDNPRSLALDP 189
Cdd:pfam00058    2 RLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 137-289 4.43e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 46.51  E-value: 4.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 631790829  137 DYPEGMAVDWMGkNLYWADTGTNRIEVARLDGQFrqVLVWRD-------LDNPRSLALDPtKGYIYWTEwGGKPRIVRAF 209
Cdd:cd14956   107 NAPRGVAVDADG-NLYVADFGNQRIQKFDPDGSF--LRQWGGtgiepgsFNYPRGVAVDP-DGTLYVAD-TYNDRIQVFD 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 631790829  210 MDGtncmTLVDKVGR----------ANDLTIDyADQRLYWTDLDTNMIESSNMLGQERVVI--ADDLPHPF----GLTQY 273
Cdd:cd14956   182 NDG----AFLRKWGGrgtgpgqfnyPYGIAID-PDGNVFVADFGNNRIQKFTADGTFLTSWgsPGTGPGQFknpwGVVVD 256

                         170
                  ....*....|....*..
gi 631790829  274 SD-YIYWTDWNLHSIER 289
Cdd:cd14956   257 ADgTVYVADSNNNRVQR 273
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
672-767 8.08e-05

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 43.98  E-value: 8.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 631790829  672 CGEppTCSPDQfACATGEIDCIPGAWRCDGfpEC-DDQSDEEGCPVCSAAQFP---CARGQCVDL----RLRCDGEadCQ 743
Cdd:NF041328   45 CGV--ACGAGQ-TCVAGACGCGPGTVACGG--ACvDTASDPAHCGACGAACAPgqvCEGGACREAcsegLTRCGGA--CV 117

                          90       100
                  ....*....|....*....|....*...
gi 631790829  744 D-RSDEAD---CDAICLPNQFrCASGQC 767
Cdd:NF041328  118 DlATDPLHcgaCGVACDPGES-CRGGAC 144
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 131-243 9.92e-05

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 45.27  E-value: 9.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 631790829  131 VVEFGLDYPEGMAVDWMGkNLYWADTGTNRIevARLDGQFRQVLVWRDLDN-PRSLALDPtKGYIYWTEwgGKPRIVRAF 209
Cdd:COG3386     2 LADAGFRLGEGPVWDPDG-RLYWVDIPGGRI--HRYDPDGGAVEVFAEPSGrPNGLAFDP-DGRLLVAD--HGRGLVRFD 75

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 631790829  210 MDGTNCMTLVDKVG----RANDLTIDyADQRLYWTDLD 243
Cdd:COG3386    76 PADGEVTVLADEYGkplnRPNDGVVD-PDGRLYFTDMG 112
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 137-213 1.20e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 44.97  E-value: 1.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 631790829  137 DYPEGMAVDwMGKNLYWADTGTNRIEVARLDGQF-RQvlVWR--DLDN----PRSLALDPtKGYIYWTE-WGGkpRIVRA 208
Cdd:cd14956    13 KDPRGIAVD-ADDNVYVADARNGRIQVFDKDGTFlRR--FGTtgDGPGqfgrPRGLAVDK-DGWLYVADyWGD--RIQVF 86


                  ....*
gi 631790829  209 FMDGT 213
Cdd:cd14956    87 TLTGE 91
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 389-428 1.58e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 39.89  E-value: 1.58e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 631790829    389 ILPLHGLRNVKAIDYDPLDKFIYWVD-GRQNIKRAKDDGTQ 428
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDwGLDVIEVANLDGTN 42
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 88-189 1.63e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 44.51  E-value: 1.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 631790829   88 IPLTGVKEASALDFDVSNNhIYWTDVS----LKTISrafmnGSSVEHVVEF-GLDYPEGMAVDWMGkNLYWADTGTNRie 162
Cdd:cd14952    46 LPFTGLYQPQGVAVDAAGT-VYVTDFGnnrvLKLAA-----GSTTQTVLPFtGLNDPTGVAVDAAG-NVYVADTGNNR-- 116

                          90       100
                  ....*....|....*....|....*....
gi 631790829  163 VARLDGQ--FRQVLVWRDLDNPRSLALDP 189
Cdd:cd14952   117 VLKLAAGsnTQTVLPFTGLSNPDGVAVDG 145
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 82-161 4.02e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 43.35  E-value: 4.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 631790829   82 NNNDVAIPLTGVKEASALDFDVSNNhIYWTDVSLKTISRaFMNGSSVEHVVEF-GLDYPEGMAVDWMGkNLYWADTGTNR 160
Cdd:cd14952   166 STTQTVLPFTGLNSPSGVAVDTAGN-VYVTDHGNNRVLK-LAAGSTTPTVLPFtGLNGPLGVAVDAAG-NVYVADRGNDR 242


                  .
gi 631790829  161 I 161
Cdd:cd14952   243 V 243
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 137-195 4.21e-04

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 43.33  E-value: 4.21e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 631790829  137 DYPEGMAVDWMGkNLYWADTGTNRIEVARLDGQFrqVLVW-------RDLDNPRSLALDPTkGYIY 195
Cdd:cd14955    16 NSPSGIAVDSAG-NVYVADTGNNRIQKFDSTGTF--LTKWgssgsgdGQFYSPTGIAVDSD-GNVY 77
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 479-522 6.26e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.35  E-value: 6.26e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 631790829    479 VVLRGDRDKPRAIVVNAERGYLYFTNMqdRAAKIERAALDGTER 522
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDW--GLDVIEVANLDGTNR 43
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 65-207 6.92e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 42.57  E-value: 6.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 631790829   65 FLVFTSRAAIHRISLETNNNDVAIPLTGVKEASA--LDFDvSNNHIYWTDVSLKTISRAFM----NGSSveHVVEFGLDY 138
Cdd:COG3386    62 LLVADHGRGLVRFDPADGEVTVLADEYGKPLNRPndGVVD-PDGRLYFTDMGEYLPTGALYrvdpDGSL--RVLADGLTF 138

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 631790829  139 PEGMAVDWMGKNLYWADTGTNRIEVARL--DGQFRQVLVWRDLD----NPRSLALDpTKGYIYWTEWGGKpRIVR 207
Cdd:COG3386   139 PNGIAFSPDGRTLYVADTGAGRIYRFDLdaDGTLGNRRVFADLPdgpgGPDGLAVD-ADGNLWVALWGGG-GVVR 211
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 192-232 1.02e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.52  E-value: 1.02e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 631790829   192 GYIYWTEWGGKPRIVRAFMDGTNCMTLV-DKVGRANDLTIDY 232
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFtDDLQHPNAIAVDP 42
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 136-195 1.82e-03

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 41.38  E-value: 1.82e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 631790829  136 LDYPEGMAVDWMGkNLYWADTGTNRIEVARLDGQF-----RQVLVWRDLDNPRSLALDPTkGYIY 195
Cdd:cd14954   117 FNYPWGVAVDSEG-RIYVSDTRNHRVQVFDSDGQFirkfgFEGAGPGQLDSPRGVAVNPD-GNIV 179
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 136-213 2.01e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 41.41  E-value: 2.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 631790829  136 LDYPEGMAVDWMGkNLYWADTGTNRIE--------VARL------DGQFrqvlvwrdlDNPRSLALDPTkGYIYWTEWGG 201
Cdd:cd14955    62 FYSPTGIAVDSDG-NVYVADTGNHRIQkfdstgtfLTKWgssgsgDGQF---------NSPSGIAVDSA-GNVYVTDSGN 130

                          90
                  ....*....|..
gi 631790829  202 kPRIVRAFMDGT 213
Cdd:cd14955   131 -NRIQKFDSSGT 141
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 275-315 2.20e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 36.75  E-value: 2.20e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 631790829   275 DYIYWTDWNLH-SIERADKTSGRNRTLIQGHLDFVMDILVFH 315
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
431-551 3.98e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.06  E-value: 3.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 631790829  431 VLTSLSQGQNPdrqpHDLSIDIYSRTLFWTCEATNTINV-HRLSGEAMGVVLRGDrdKPRAIVVNAERGYLYFTNMQ-DR 508
Cdd:COG3391   102 VVATIPVGGGP----RGLAVDPDGGRLYVADSGNGRVSViDTATGKVVATIPVGA--GPHGIAVDPDGKRLYVANSGsNT 175

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 631790829  509 AAKIErAALDGTEREVLFTTGL-IRPVALVVDNTLGKLFWVDAD 551
Cdd:COG3391   176 VSVIV-SVIDTATGKVVATIPVgGGPVGVAVSPDGRRLYVANRG 218
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 139-213 6.00e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 39.96  E-value: 6.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 631790829  139 PEGMAVDWMGkNLYWADTGTNRIEVARLDGQFRQVLVWR-----DLDNPRSLALDPtKGYIYWTEWGGKpRIVRAFMDGT 213
Cdd:cd14956    62 PRGLAVDKDG-WLYVADYWGDRIQVFTLTGELQTIGGSSgsgpgQFNAPRGVAVDA-DGNLYVADFGNQ-RIQKFDPDGS 138
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 235-271 7.31e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 35.21  E-value: 7.31e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 631790829   235 QRLYWTDLDT-NMIESSNMLGQER-VVIADDLPHPFGLT 271
Cdd:pfam00058    1 GRLYWTDSSLrASISSADLNGSDRkTLFTDDLQHPNAIA 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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