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Conserved domains on  [gi|635172847|ref|NP_001278935|]
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kelch-like protein 8 isoform 2 [Homo sapiens]

Protein Classification

kelch-like protein( domain architecture ID 13335461)

kelch-like protein similar to Homo sapiens kelch-like proteins, KLHL11, KLHL12, KLHL17 and KLHL24, which may function as substrate-specific adaptors of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 87-183 6.03e-63

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


:

Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 201.00  E-value: 6.03e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  87 HFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANP 166
Cdd:cd18448    1 HLHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDP 80

                         90
                 ....*....|....*..
gi 635172847 167 QHHSKWLDETLAQVRLP 183
Cdd:cd18448   81 QHRKRHLDDLLSQVRLP 97
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
235-489 1.42e-55

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 188.06  E-value: 1.42e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 235 TPRKHTAGVLfcVGGR----GG--SGDPFRSIECYSINKNSWFFGPEMNSRRR-HVGVISVEGKVYAVGGHDGN----EH 303
Cdd:COG3055   11 TPRSEAAAAL--LDGKvyvaGGlsGGSASNSFEVYDPATNTWSELAPLPGPPRhHAAAVAQDGKLYVFGGFTGAnpssTP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 304 LGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALV 383
Cdd:COG3055   89 LNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLP 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 384 N-HVYAVGGNDGmaslssveryDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGfdDNSPLSSVERYDPRSNKWDYVA 462
Cdd:COG3055  169 DgKILVIGGRNG----------SGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGG--ESGFSDEVEAYDPATNTWTALG 236

                        250       260
                 ....*....|....*....|....*..
gi 635172847 463 ALTTPRGGVGIATVMGKIFAVGGHNGN 489
Cdd:COG3055  237 ELPTPRHGHAAVLTDGKVYVIGGETKP 263
Kelch smart00612
Kelch domain;
479-523 6.10e-12

Kelch domain;


:

Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 60.26  E-value: 6.10e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 635172847   479 KIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVC 523
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 52-95 3.61e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18238:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 120  Bit Score: 57.68  E-value: 3.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  52 DFHGSLLRFYENGELCDVTLKV---------------------------------------------------------- 73
Cdd:cd18238    1 DSFKVLHQFYENGELCDVTLKVgeksihchrlvlacvspyframftsemaeskqdsitikdideeavellvdfaytgklt 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 635172847  74 ------------------ELVARACCEYMKLHFHPSNCLA 95
Cdd:cd18238   81 ltvdnvqsllyaasllqvEEVAKACCEFMKDHLHPSNCLG 120
 
Name Accession Description Interval E-value
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 87-183 6.03e-63

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 201.00  E-value: 6.03e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  87 HFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANP 166
Cdd:cd18448    1 HLHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDP 80

                         90
                 ....*....|....*..
gi 635172847 167 QHHSKWLDETLAQVRLP 183
Cdd:cd18448   81 QHRKRHLDDLLSQVRLP 97
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
235-489 1.42e-55

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 188.06  E-value: 1.42e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 235 TPRKHTAGVLfcVGGR----GG--SGDPFRSIECYSINKNSWFFGPEMNSRRR-HVGVISVEGKVYAVGGHDGN----EH 303
Cdd:COG3055   11 TPRSEAAAAL--LDGKvyvaGGlsGGSASNSFEVYDPATNTWSELAPLPGPPRhHAAAVAQDGKLYVFGGFTGAnpssTP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 304 LGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALV 383
Cdd:COG3055   89 LNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLP 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 384 N-HVYAVGGNDGmaslssveryDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGfdDNSPLSSVERYDPRSNKWDYVA 462
Cdd:COG3055  169 DgKILVIGGRNG----------SGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGG--ESGFSDEVEAYDPATNTWTALG 236

                        250       260
                 ....*....|....*....|....*..
gi 635172847 463 ALTTPRGGVGIATVMGKIFAVGGHNGN 489
Cdd:COG3055  237 ELPTPRHGHAAVLTDGKVYVIGGETKP 263
PHA03098 PHA03098
kelch-like protein; Provisional
 56-459 8.90e-55

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 193.06  E-value: 8.90e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  56 SLLRFYENG----ELCDVT--------LKVELVARACCEYMKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEV 123
Cdd:PHA03098  61 EVIKYIYTGkiniTSNNVKdilsianyLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELI 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 124 VECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVD-------FLMGVVAK 196
Cdd:PHA03098 141 YNDPDFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEgikklkrWKLRIKKK 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 197 EQIVKQNLKCR--------------------DLLDEARNYHLHLSSRAVPDFEYSIRTTPRKHTAG---------VLFCV 247
Cdd:PHA03098 221 KIVFNKRCIKIiyskkynlnkilprsstfgsIIYIHITMSIFTYNYITNYSPLSEINTIIDIHYVYcfgsvvlnnVIYFI 300

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 248 GGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKR 327
Cdd:PHA03098 301 GGMNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPR 380

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 328 RGIALASLGGPIYAIGGLDDN-TCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGG---NDGMASLSSVER 403
Cdd:PHA03098 381 YNPCVVNVNNLIYVIGGISKNdELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGisyIDNIKVYNIVES 460

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 635172847 404 YDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWD 459
Cdd:PHA03098 461 YNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWT 516
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 93-195 3.07e-37

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 133.05  E-value: 3.07e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847   93 CLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHSKW 172
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 635172847  173 LDETLAQVRLPLLPVDFLMGVVA 195
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 93-193 2.37e-32

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 119.75  E-value: 2.37e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847    93 CLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHSKW 172
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 635172847   173 LDETLAQVRLPLLPVDFLMGV 193
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
Kelch smart00612
Kelch domain;
432-478 2.08e-13

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 64.50  E-value: 2.08e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 635172847   432 CLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMG 478
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch smart00612
Kelch domain;
479-523 6.10e-12

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 60.26  E-value: 6.10e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 635172847   479 KIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVC 523
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 279-324 6.40e-12

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 60.32  E-value: 6.40e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 635172847  279 RRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMN 324
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-95 3.61e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 57.68  E-value: 3.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  52 DFHGSLLRFYENGELCDVTLKV---------------------------------------------------------- 73
Cdd:cd18238    1 DSFKVLHQFYENGELCDVTLKVgeksihchrlvlacvspyframftsemaeskqdsitikdideeavellvdfaytgklt 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 635172847  74 ------------------ELVARACCEYMKLHFHPSNCLA 95
Cdd:cd18238   81 ltvdnvqsllyaasllqvEEVAKACCEFMKDHLHPSNCLG 120
muta_rot_YjhT TIGR03547
mutatrotase, YjhT family; Members of this protein family contain multiple copies of the ...
 374-500 7.40e-05

mutatrotase, YjhT family; Members of this protein family contain multiple copies of the beta-propeller-forming Kelch repeat. All are full-length homologs to YjhT of Escherichia coli, which has been identified as a mutarotase for sialic acid. This protein improves bacterial ability to obtain host sialic acid, and thus serves as a virulence factor. Some bacteria carry what appears to be a cyclically permuted homolog of this protein.


Pssm-ID: 274641 [Multi-domain]  Cd Length: 346  Bit Score: 45.01  E-value: 7.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  374 RGGVGsvALVNHVYAVGGNDGMASLSSVERYDPHlDKWIEVKEM-GQRRAGNGVSKLHGCLYVVGGF----DDNSP--LS 446
Cdd:TIGR03547   9 KNGTG--AIIGDKVYVGLGSAGTSWYKLDLKKPS-KGWQKIADFpGGPRNQAVAAAIDGKLYVFGGIgkanSEGSPqvFD 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  447 SVERYDPRSNKWDYVAAlTTPRGGVGIATVM---GKIFAVGGHNG---NAYLNTVEAFDP 500
Cdd:TIGR03547  86 DVYRYDPKKNSWQKLDT-RSPVGLLGASGFSlhnGQAYFTGGVNKnifDGYFADLSAADK 144
Kelch_6 pfam13964
Kelch motif;
467-515 6.16e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 35.00  E-value: 6.16e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 635172847  467 PRGGVGIATVMGKIFAVGG-HNGNAYLNTVEAFDPVLNRWELVGSVSHCR 515
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGyTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
 
Name Accession Description Interval E-value
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 87-183 6.03e-63

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 201.00  E-value: 6.03e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  87 HFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANP 166
Cdd:cd18448    1 HLHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDP 80

                         90
                 ....*....|....*..
gi 635172847 167 QHHSKWLDETLAQVRLP 183
Cdd:cd18448   81 QHRKRHLDDLLSQVRLP 97
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
235-489 1.42e-55

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 188.06  E-value: 1.42e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 235 TPRKHTAGVLfcVGGR----GG--SGDPFRSIECYSINKNSWFFGPEMNSRRR-HVGVISVEGKVYAVGGHDGN----EH 303
Cdd:COG3055   11 TPRSEAAAAL--LDGKvyvaGGlsGGSASNSFEVYDPATNTWSELAPLPGPPRhHAAAVAQDGKLYVFGGFTGAnpssTP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 304 LGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALV 383
Cdd:COG3055   89 LNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLP 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 384 N-HVYAVGGNDGmaslssveryDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGfdDNSPLSSVERYDPRSNKWDYVA 462
Cdd:COG3055  169 DgKILVIGGRNG----------SGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGG--ESGFSDEVEAYDPATNTWTALG 236

                        250       260
                 ....*....|....*....|....*..
gi 635172847 463 ALTTPRGGVGIATVMGKIFAVGGHNGN 489
Cdd:COG3055  237 ELPTPRHGHAAVLTDGKVYVIGGETKP 263
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
269-522 2.77e-55

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 187.29  E-value: 2.77e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 269 SWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRR-GIALASLGGPIYAIGGLDD 347
Cdd:COG3055    2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPPRhHAAAVAQDGKLYVFGGFTG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 348 N----TCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAG 423
Cdd:COG3055   82 AnpssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDH 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 424 -NGVSKLHGCLYVVGGFDDNSPlssverydprSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGnaYLNTVEAFDPVL 502
Cdd:COG3055  162 lAAAVLPDGKILVIGGRNGSGF----------SNTWTTLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPAT 229

                        250       260
                 ....*....|....*....|
gi 635172847 503 NRWELVGSVSHCRAGAGVAV 522
Cdd:COG3055  230 NTWTALGELPTPRHGHAAVL 249
PHA03098 PHA03098
kelch-like protein; Provisional
 56-459 8.90e-55

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 193.06  E-value: 8.90e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  56 SLLRFYENG----ELCDVT--------LKVELVARACCEYMKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEV 123
Cdd:PHA03098  61 EVIKYIYTGkiniTSNNVKdilsianyLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELI 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 124 VECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVD-------FLMGVVAK 196
Cdd:PHA03098 141 YNDPDFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEgikklkrWKLRIKKK 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 197 EQIVKQNLKCR--------------------DLLDEARNYHLHLSSRAVPDFEYSIRTTPRKHTAG---------VLFCV 247
Cdd:PHA03098 221 KIVFNKRCIKIiyskkynlnkilprsstfgsIIYIHITMSIFTYNYITNYSPLSEINTIIDIHYVYcfgsvvlnnVIYFI 300

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 248 GGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKR 327
Cdd:PHA03098 301 GGMNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPR 380

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 328 RGIALASLGGPIYAIGGLDDN-TCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGG---NDGMASLSSVER 403
Cdd:PHA03098 381 YNPCVVNVNNLIYVIGGISKNdELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGisyIDNIKVYNIVES 460

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 635172847 404 YDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWD 459
Cdd:PHA03098 461 YNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWT 516
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 93-195 3.07e-37

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 133.05  E-value: 3.07e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847   93 CLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHSKW 172
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 635172847  173 LDETLAQVRLPLLPVDFLMGVVA 195
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 90-218 1.15e-35

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 129.83  E-value: 1.15e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  90 PSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 169
Cdd:cd18452    3 PSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKEER 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 635172847 170 SKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHL 218
Cdd:cd18452   83 EDYLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKFHL 131
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 89-201 4.09e-35

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 127.73  E-value: 4.09e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  89 HPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQH 168
Cdd:cd18445    2 HPSNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPEN 81

                         90       100       110
                 ....*....|....*....|....*....|...
gi 635172847 169 HSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVK 201
Cdd:cd18445   82 RKEHLAELLEHVRLPLLSPEYLVQRVEEEELIK 114
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 93-193 2.37e-32

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 119.75  E-value: 2.37e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847    93 CLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHSKW 172
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 635172847   173 LDETLAQVRLPLLPVDFLMGV 193
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 88-217 5.52e-32

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 119.79  E-value: 5.52e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  88 FHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQ 167
Cdd:cd18513    1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 635172847 168 HHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYH 217
Cdd:cd18513   81 ARLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 130
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 89-191 2.46e-31

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 117.05  E-value: 2.46e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  89 HPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQH 168
Cdd:cd18444    3 HPSNCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDLPE 82

                         90       100
                 ....*....|....*....|...
gi 635172847 169 HSKWLDETLAQVRLPLLPVDFLM 191
Cdd:cd18444   83 RKKHLAKLLALIRLPLLTPQFLA 105
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 88-217 3.96e-30

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 114.74  E-value: 3.96e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  88 FHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQ 167
Cdd:cd18512    1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 635172847 168 HHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYH 217
Cdd:cd18512   81 VRQEHMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMKYH 130
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 88-190 9.88e-26

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 101.25  E-value: 9.88e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  88 FHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQ 167
Cdd:cd18509    2 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQ 81

                         90       100
                 ....*....|....*....|...
gi 635172847 168 HHSKWLDETLAQVRLPLLPVDFL 190
Cdd:cd18509   82 RRCSDLSMLLAYIRLPLLPPQLL 104
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 87-190 1.34e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 95.52  E-value: 1.34e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  87 HFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANP 166
Cdd:cd18511    1 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDV 80

                         90       100
                 ....*....|....*....|....
gi 635172847 167 QHHSKWLDETLAQVRLPLLPVDFL 190
Cdd:cd18511   81 EQRRKDLSKLLAYIRLPLLAPQFL 104
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 90-185 9.24e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 92.88  E-value: 9.24e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  90 PSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 169
Cdd:cd18459    4 PSNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNIQER 83

                         90
                 ....*....|....*.
gi 635172847 170 SKWLDETLAQVRLPLL 185
Cdd:cd18459   84 RPHLPQVLQHVRLPLL 99
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 87-190 2.65e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 91.90  E-value: 2.65e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  87 HFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANP 166
Cdd:cd18510    1 QLHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDL 80

                         90       100
                 ....*....|....*....|....
gi 635172847 167 QHHSKWLDETLAQVRLPLLPVDFL 190
Cdd:cd18510   81 QNRQKDLGMLLSYIRLPLLPPQLL 104
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 88-194 5.65e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 90.83  E-value: 5.65e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  88 FHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQ 167
Cdd:cd18457    1 LHPNNCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRE 80

                         90       100
                 ....*....|....*....|....*..
gi 635172847 168 HHSKWLDETLAQVRLPLLPVDFLMGVV 194
Cdd:cd18457   81 NREEYLPELLSKVRLPLLRPQFLTDRV 107
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 90-186 2.56e-21

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 88.69  E-value: 2.56e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  90 PSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 169
Cdd:cd18466    3 PANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVGKR 82

                         90
                 ....*....|....*..
gi 635172847 170 SKWLDETLAQVRLPLLP 186
Cdd:cd18466   83 KKHVVEVLEPVRFPLLP 99
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 89-190 1.73e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 86.31  E-value: 1.73e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  89 HPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQH 168
Cdd:cd18468    1 TPSNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKN 80

                         90       100
                 ....*....|....*....|..
gi 635172847 169 HSKWLDETLAQVRLPLLPVDFL 190
Cdd:cd18468   81 RKQHIAELLAVVRLPFIHPSYL 102
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 91-162 6.92e-19

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 80.92  E-value: 6.92e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 635172847  91 SNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWL 162
Cdd:cd18508    3 TNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWL 74
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 90-177 2.21e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 80.03  E-value: 2.21e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  90 PSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 169
Cdd:cd18458    4 PSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDEENR 83


                 ....*...
gi 635172847 170 SKWLDETL 177
Cdd:cd18458   84 RQYLEALL 91
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 90-189 1.19e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 75.42  E-value: 1.19e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  90 PSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWL---LANP 166
Cdd:cd18456    3 PSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVkhdVDGR 82

                         90       100
                 ....*....|....*....|...
gi 635172847 167 QHHSKWLdetLAQVRLPLLPVDF 189
Cdd:cd18456   83 RQHVPRL---MKCVRLPLLSRDF 102
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 90-185 6.85e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 73.44  E-value: 6.85e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  90 PSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 169
Cdd:cd18467    3 PGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQER 82

                         90
                 ....*....|....*.
gi 635172847 170 SKWLDETLAQVRLPLL 185
Cdd:cd18467   83 QKYLAQLLHCVRLPLL 98
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 91-167 1.38e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 71.97  E-value: 1.38e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 635172847  91 SNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQ 167
Cdd:cd18480    4 SNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLE 80
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 88-186 5.30e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 70.64  E-value: 5.30e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  88 FHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQ 167
Cdd:cd18514    1 LHPSNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLE 80

                         90
                 ....*....|....*....
gi 635172847 168 HHSKWLDETLAQVRLPLLP 186
Cdd:cd18514   81 KRKDYLPELLRNVRLALLP 99
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 89-186 1.08e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 69.83  E-value: 1.08e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  89 HPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQH 168
Cdd:cd18464    1 HPSNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPR 80

                         90
                 ....*....|....*...
gi 635172847 169 HSKWLDETLAQVRLPLLP 186
Cdd:cd18464   81 RHEVLPELLRSVRLALLP 98
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 91-184 1.18e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 69.69  E-value: 1.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  91 SNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHS 170
Cdd:cd18447    5 SNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQ 84

                         90
                 ....*....|....
gi 635172847 171 KWLDETLAQVRLPL 184
Cdd:cd18447   85 PYMVDILAKVRFPL 98
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 89-143 7.49e-14

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 66.15  E-value: 7.49e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 635172847  89 HPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSS 143
Cdd:cd14733    1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 89-186 8.17e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 67.31  E-value: 8.17e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  89 HPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQH 168
Cdd:cd18515    1 HPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKK 80

                         90
                 ....*....|....*...
gi 635172847 169 HSKWLDETLAQVRLPLLP 186
Cdd:cd18515   81 RHCYLSELLQTVRLALLP 98
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 90-184 1.13e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 67.06  E-value: 1.13e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  90 PSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 169
Cdd:cd18485    3 ASNCLGIYYFAKQIGAEDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRKSR 82

                         90
                 ....*....|....*
gi 635172847 170 SKWLDETLAQVRLPL 184
Cdd:cd18485   83 VQHLVELLKQVRLEL 97
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 90-162 2.01e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 65.49  E-value: 2.01e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 635172847  90 PSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWL 162
Cdd:cd18472    3 PANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75
Kelch smart00612
Kelch domain;
432-478 2.08e-13

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 64.50  E-value: 2.08e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 635172847   432 CLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMG 478
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch smart00612
Kelch domain;
291-337 2.45e-13

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 64.12  E-value: 2.45e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 635172847   291 KVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGG 337
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 90-186 2.77e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 66.02  E-value: 2.77e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  90 PSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 169
Cdd:cd18477    3 LGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKENR 82

                         90
                 ....*....|....*..
gi 635172847 170 SKWLDETLAQVRLPLLP 186
Cdd:cd18477   83 QKALPTVFESIRFRLLP 99
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 89-194 3.43e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 65.95  E-value: 3.43e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  89 HPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQH 168
Cdd:cd18446    2 HPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKESE 81

                         90       100
                 ....*....|....*....|....*.
gi 635172847 169 HSKWLDETLAQVRLPLLPVDFLMGVV 194
Cdd:cd18446   82 RLPLLPRVLENVRLPLLDPWYFVETV 107
PLN02193 PLN02193
nitrile-specifier protein
 284-461 3.77e-13

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 71.53  E-value: 3.77e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 284 GVISVEGKVYAVGG-----HDGNEHLgsmEMFDPLTNKWMMKASM----NTKRRGIALASLGGPIYAIGGLDDNTCFNDV 354
Cdd:PLN02193 170 GIAQVGNKIYSFGGeftpnQPIDKHL---YVFDLETRTWSISPATgdvpHLSCLGVRMVSIGSTLYVFGGRDASRQYNGF 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 355 ERYDIESDQWSTVAPMN---TPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQR---RAGNGVSK 428
Cdd:PLN02193 247 YSFDTTTNEWKLLTPVEegpTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWFHCSTPGDSfsiRGGAGLEV 326

                        170       180       190
                 ....*....|....*....|....*....|...
gi 635172847 429 LHGCLYVVGGFdDNSPLSSVERYDPRSNKWDYV 461
Cdd:PLN02193 327 VQGKVWVVYGF-NGCEVDDVHYYDPVQDKWTQV 358
Kelch smart00612
Kelch domain;
339-382 3.92e-13

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 63.73  E-value: 3.92e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 635172847   339 IYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVAL 382
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45
PLN02153 PLN02153
epithiospecifier protein
 284-461 6.27e-13

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 70.02  E-value: 6.27e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 284 GVISVEGKVYAVGGH-DGNEHLGS-MEMFDPLTNKWMMKASMNTKRR----GIALASLGGPIYAIGGLDDNTCFNDVERY 357
Cdd:PLN02153  27 GIAVVGDKLYSFGGElKPNEHIDKdLYVFDFNTHTWSIAPANGDVPRisclGVRMVAVGTKLYIFGGRDEKREFSDFYSY 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 358 DIESDQWSTVAPMNTPRGGVGSV-----ALVNHVYAVGG--NDGMAS----LSSVERYDPHLDKWIEVKEMG---QRRAG 423
Cdd:PLN02153 107 DTVKNEWTFLTKLDEEGGPEARTfhsmaSDENHVYVFGGvsKGGLMKtperFRTIEAYNIADGKWVQLPDPGenfEKRGG 186

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 635172847 424 NGVSKLHGCLYVVGGF--------DDNSPLSSVERYDPRSNKWDYV 461
Cdd:PLN02153 187 AGFAVVQGKIWVVYGFatsilpggKSDYESNAVQFFDPASGKWTEV 232
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 89-161 1.92e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 62.80  E-value: 1.92e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 635172847  89 HPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKW 161
Cdd:cd18463    3 DPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRW 75
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 90-186 1.96e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 63.25  E-value: 1.96e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  90 PSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 169
Cdd:cd18517    3 VGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKENR 82

                         90
                 ....*....|....*..
gi 635172847 170 SKWLDETLAQVRLPLLP 186
Cdd:cd18517   83 VKSLGEIFDCIRFRLMP 99
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 91-186 2.65e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 63.24  E-value: 2.65e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  91 SNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHS 170
Cdd:cd18516    4 SNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQEERT 83

                         90
                 ....*....|....*.
gi 635172847 171 KWLDETLAQVRLPLLP 186
Cdd:cd18516   84 KALPVLLESIRFRLMP 99
Kelch smart00612
Kelch domain;
479-523 6.10e-12

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 60.26  E-value: 6.10e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 635172847   479 KIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVC 523
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 279-324 6.40e-12

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 60.32  E-value: 6.40e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 635172847  279 RRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMN 324
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 420-465 1.64e-11

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 59.16  E-value: 1.64e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 635172847  420 RRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALT 465
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 327-371 2.94e-11

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 58.39  E-value: 2.94e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 635172847  327 RRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMN 371
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
385-426 7.03e-11

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 57.18  E-value: 7.03e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 635172847   385 HVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGV 426
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGV 42
PLN02153 PLN02153
epithiospecifier protein
 332-508 9.49e-11

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 63.47  E-value: 9.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 332 LASLGGPIYAIGG-LDDNTCFN-DVERYDIESDQWStVAPMN--TPR---GGVGSVALVNHVYAVGGNDGMASLSSVERY 404
Cdd:PLN02153  28 IAVVGDKLYSFGGeLKPNEHIDkDLYVFDFNTHTWS-IAPANgdVPRiscLGVRMVAVGTKLYIFGGRDEKREFSDFYSY 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 405 DPHLDKW---IEVKEMG--QRRAGNGVSKLHGCLYVVGGFDD----NSP--LSSVERYDPRSNKWdyvAALTTP------ 467
Cdd:PLN02153 107 DTVKNEWtflTKLDEEGgpEARTFHSMASDENHVYVFGGVSKgglmKTPerFRTIEAYNIADGKW---VQLPDPgenfek 183

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 635172847 468 RGGVGIATVMGKIFAV---------GGHNgNAYLNTVEAFDPVLNRWELV 508
Cdd:PLN02153 184 RGGAGFAVVQGKIWVVygfatsilpGGKS-DYESNAVQFFDPASGKWTEV 232
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 89-166 9.54e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 58.01  E-value: 9.54e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 635172847  89 HPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVE-CEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANP 166
Cdd:cd18450    2 TPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAKdSEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHDP 80
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 90-183 1.12e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 58.33  E-value: 1.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  90 PSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 169
Cdd:cd18483    3 PQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQSKR 82

                         90
                 ....*....|....*
gi 635172847 170 SKWLDETLAQ-VRLP 183
Cdd:cd18483   83 EMHLPEIFAKcIRMP 97
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 90-185 1.27e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 58.27  E-value: 1.27e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  90 PSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 169
Cdd:cd18460    3 VSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPKHR 82

                         90
                 ....*....|....*.
gi 635172847 170 SKWLDETLAQVRLPLL 185
Cdd:cd18460   83 QHFWPELLQHVRLPFV 98
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 92-182 1.43e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 58.14  E-value: 1.43e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  92 NCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHSK 171
Cdd:cd18479    5 NCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTESRSQ 84

                         90
                 ....*....|.
gi 635172847 172 WLDETLAQVRL 182
Cdd:cd18479   85 YLSSVLSQIRI 95
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 90-181 2.68e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 57.33  E-value: 2.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  90 PSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 169
Cdd:cd18455    2 AENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEER 81

                         90
                 ....*....|..
gi 635172847 170 SKWLDETLAQVR 181
Cdd:cd18455   82 KVHLKDLMSSCW 93
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-95 3.61e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 57.68  E-value: 3.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  52 DFHGSLLRFYENGELCDVTLKV---------------------------------------------------------- 73
Cdd:cd18238    1 DSFKVLHQFYENGELCDVTLKVgeksihchrlvlacvspyframftsemaeskqdsitikdideeavellvdfaytgklt 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 635172847  74 ------------------ELVARACCEYMKLHFHPSNCLA 95
Cdd:cd18238   81 ltvdnvqsllyaasllqvEEVAKACCEFMKDHLHPSNCLG 120
PHA02790 PHA02790
Kelch-like protein; Provisional
 335-507 3.66e-10

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 62.37  E-value: 3.66e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 335 LGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGgndGMASLSSVERYDPHLDKWIEV 414
Cdd:PHA02790 270 VGEVVYLIGGWMNNEIHNNAIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVG---GLPNPTSVERWFHGDAAWVNM 346

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 415 KEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLS-------------------------------------SVERYDPRSNK 457
Cdd:PHA02790 347 PSLLKPRCNPAVASINNVIYVIGGHSETDTTTeyllpnhdqwqfgpstyyphykscalvfgrrlflvgrNAEFYCESSNT 426

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 635172847 458 WDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWEL 507
Cdd:PHA02790 427 WTLIDDPIYPRDNPELIIVDNKLLLIGGFYRGSYIDTIEVYNNRTYSWNI 476
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 90-180 5.79e-10

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 56.47  E-value: 5.79e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  90 PSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSD-LNIENEKQVYNAAIKWLLANPQH 168
Cdd:cd18502    3 PENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAESKEFLKLPRLQIEVILESNQeLESINERKLCQLVLEWVQRSIEE 82

                         90
                 ....*....|..
gi 635172847 169 HSKWLDETLAQV 180
Cdd:cd18502   83 GGLDLDDLTEKV 94
PLN02193 PLN02193
nitrile-specifier protein
 283-420 6.17e-10

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 61.51  E-value: 6.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 283 VGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMN---TKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDI 359
Cdd:PLN02193 222 VRMVSIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEegpTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNI 301

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 635172847 360 ESDQW---STVAPMNTPRGGVGSVALVNHVYAVGGNDGmASLSSVERYDPHLDKWIEVKEMGQR 420
Cdd:PLN02193 302 VDKKWfhcSTPGDSFSIRGGAGLEVVQGKVWVVYGFNG-CEVDDVHYYDPVQDKWTQVETFGVR 364
PHA03098 PHA03098
kelch-like protein; Provisional
 429-522 1.06e-09

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 60.94  E-value: 1.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 429 LHGCLYVVGGFDDNS-PLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWEL 507
Cdd:PHA03098 293 LNNVIYFIGGMNKNNlSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWRE 372

                         90
                 ....*....|....*
gi 635172847 508 VGSVSHCRAGAGVAV 522
Cdd:PHA03098 373 EPPLIFPRYNPCVVN 387
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 90-189 1.56e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 55.15  E-value: 1.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  90 PSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 169
Cdd:cd18469    5 ATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHDPQAR 84

                         90       100
                 ....*....|....*....|
gi 635172847 170 SKWLDETLAQVRLPLLPVDF 189
Cdd:cd18469   85 AAHLPELLSLVHLSLLTDQY 104
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 467-510 1.59e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 53.38  E-value: 1.59e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 635172847  467 PRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGS 510
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPS 44
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 373-418 5.96e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 51.84  E-value: 5.96e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 635172847  373 PRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMG 418
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
PLN02153 PLN02153
epithiospecifier protein
 244-426 2.06e-08

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 56.15  E-value: 2.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 244 LFCVGGRGGSGDPF-RSIECYSINKNSWFFGPEMNSRRR----HVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWM 318
Cdd:PLN02153  35 LYSFGGELKPNEHIdKDLYVFDFNTHTWSIAPANGDVPRisclGVRMVAVGTKLYIFGGRDEKREFSDFYSYDTVKNEWT 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 319 MKASMNTK-----RRGIALASLGGPIYAIGGLDDN------TCFNDVERYDIESDQWSTVA-PMNT--PRGGVGSVALVN 384
Cdd:PLN02153 115 FLTKLDEEggpeaRTFHSMASDENHVYVFGGVSKGglmktpERFRTIEAYNIADGKWVQLPdPGENfeKRGGAGFAVVQG 194

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 635172847 385 HVYAV---------GGNDGMASlSSVERYDPHLDKWIEVKEMGQRRAGNGV 426
Cdd:PLN02153 195 KIWVVygfatsilpGGKSDYES-NAVQFFDPASGKWTEVETTGAKPSARSV 244
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 92-165 4.63e-08

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 50.42  E-value: 4.63e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 635172847  92 NCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLAN 165
Cdd:cd18503    5 NCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEHN 78
PHA02790 PHA02790
Kelch-like protein; Provisional
 73-459 5.84e-08

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 55.43  E-value: 5.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  73 VELVARACCEYMKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTE----VVECEDFVSvspqhLHKLLSSSDLNI 148
Cdd:PHA02790 105 VEFIIYTCINFILRDFRKEYCVECYMMGIEYGLSNLLCHTKDFIAKHFLEleddIIDNFDYLS-----MKLILESDELNV 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 149 ENEKQVYNAAIKWLLANPQHhskwldetLAQVRLpllpvdFLMGVVAKEQIVKQNLK-CRDLLDEARNYHLHLSSRA--- 224
Cdd:PHA02790 180 PDEDYVVDFVIKWYMKRRNR--------LGNLLL------LIKNVIRSNYLSPRGINnVKWILDCTKIFHCDKQPRKsyk 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 225 VPDFEYSI---------RTTPRKHTAGVLFCVGGRGGSGDPFRSIECYSINkNSWFFGPEMNSRRRHVGVISVEGKVYAV 295
Cdd:PHA02790 246 YPFIEYPMnmdqiidifHMCTSTHVGEVVYLIGGWMNNEIHNNAIAVNYIS-NNWIPIPPMNSPRLYASGVPANNKLYVV 324

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 296 GGHDGNEhlgSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNTcfNDVERYDIESDQWSTVAPMNTPRG 375
Cdd:PHA02790 325 GGLPNPT---SVERWFHGDAAWVNMPSLLKPRCNPAVASINNVIYVIGGHSETD--TTTEYLLPNHDQWQFGPSTYYPHY 399

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 376 GVGSVALVNHVYAVGGNdgmaslssVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRS 455
Cdd:PHA02790 400 KSCALVFGRRLFLVGRN--------AEFYCESSNTWTLIDDPIYPRDNPELIIVDNKLLLIGGFYRGSYIDTIEVYNNRT 471


                 ....
gi 635172847 456 NKWD 459
Cdd:PHA02790 472 YSWN 475
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 90-183 1.49e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 49.35  E-value: 1.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  90 PSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIEnEKQVYNAAIKWLLANPQHH 169
Cdd:cd18476    3 PSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDELCGE-EEQVFETLMVWIRHDPKAR 81

                         90
                 ....*....|....
gi 635172847 170 SKWLDETLAQVRLP 183
Cdd:cd18476   82 KGYIHDLFKKVRLQ 95
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 92-189 2.92e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 48.96  E-value: 2.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  92 NCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHSK 171
Cdd:cd18462    5 NCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVEKRIE 84

                         90
                 ....*....|....*...
gi 635172847 172 WLDETLAQVRLPLLPVDF 189
Cdd:cd18462   85 CAYDLLSSIKLDLDEIYL 102
PRK14131 PRK14131
N-acetylneuraminate epimerase;
374-521 3.60e-07

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 52.32  E-value: 3.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 374 RGGVGsvALVNHVYAVGGNDGMASLSSVERYDPHlDKWIEVKEM-GQRRAGNGVSKLHGCLYVVGGF----DDNSP--LS 446
Cdd:PRK14131  30 KNGTG--AIDNNTVYVGLGSAGTSWYKLDLNAPS-KGWTKIAAFpGGPREQAVAAFIDGKLYVFGGIgktnSEGSPqvFD 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 447 SVERYDPRSNKWDYVAAlTTPRGGVGIATVM---GKIFAVGGHNG---NAYLNTVEA----------------------- 497
Cdd:PRK14131 107 DVYKYDPKTNSWQKLDT-RSPVGLAGHVAVSlhnGKAYITGGVNKnifDGYFEDLAAagkdktpkdkindayfdkkpedy 185

                        170       180       190
                 ....*....|....*....|....*....|...
gi 635172847 498 --------FDPVLNRWELVGSVSHC-RAGAGVA 521
Cdd:PRK14131 186 ffnkevlsYDPSTNQWKNAGESPFLgTAGSAVV 218
Kelch_6 pfam13964
Kelch motif;
327-374 3.65e-07

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 46.94  E-value: 3.65e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 635172847  327 RRGIALASLGGPIYAIGGLDD-NTCFNDVERYDIESDQWSTVAPMNTPR 374
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNaSPALNKLEVYNPLTKSWEELPPLPTPR 50
PRK14131 PRK14131
N-acetylneuraminate epimerase;
315-391 1.13e-06

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 50.78  E-value: 1.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 315 NKWMMKASM-NTKRRGIALASLGGPIYAIGGLDDN------TCFNDVERYDIESDQWSTVaPMNTPRGGVGSVALVNH-- 385
Cdd:PRK14131  62 KGWTKIAAFpGGPREQAVAAFIDGKLYVFGGIGKTnsegspQVFDDVYKYDPKTNSWQKL-DTRSPVGLAGHVAVSLHng 140


                 ....*..
gi 635172847 386 -VYAVGG 391
Cdd:PRK14131 141 kAYITGG 147
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 91-166 1.20e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 46.34  E-value: 1.20e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 635172847  91 SNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANP 166
Cdd:cd18474    4 NNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDADP 79
Kelch smart00612
Kelch domain;
243-290 1.70e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 44.86  E-value: 1.70e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 635172847   243 VLFCVGGRGGsGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEG 290
Cdd:smart00612   1 KIYVVGGFDG-GQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 93-185 1.94e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 46.44  E-value: 1.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  93 CLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHSKw 172
Cdd:cd18465    6 CLNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHDPSRRAS- 84

                         90
                 ....*....|...
gi 635172847 173 LDETLAQVRLPLL 185
Cdd:cd18465   85 ASHVLCHIRFPLM 97
Kelch_6 pfam13964
Kelch motif;
421-468 2.13e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 44.63  E-value: 2.13e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 635172847  421 RAGNGVSKLHGCLYVVGGFDD-NSPLSSVERYDPRSNKWDYVAALTTPR 468
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNaSPALNKLEVYNPLTKSWEELPPLPTPR 50
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 107-186 2.87e-06

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 46.07  E-value: 2.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 107 DLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLsSSDLNIENEKQVYNAAIKWLLANPQHHSKwLDETLAQVRLPLLP 186
Cdd:cd14822   20 DLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELL-SRDSFCAPEVDIFNAVRRWCEHNPDSKED-AKEILEAVRLPLMS 97
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 92-182 3.91e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 45.64  E-value: 3.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  92 NCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANpQHHSK 171
Cdd:cd18470    5 NCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFD-QKRVK 83

                         90
                 ....*....|.
gi 635172847 172 WLDETLAQVRL 182
Cdd:cd18470   84 YAADLLSNIRF 94
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 99-162 5.87e-06

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 44.11  E-value: 5.87e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 635172847  99 FAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWL 162
Cdd:cd18493   11 YAKMCGHKELAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74
Kelch_3 pfam13415
Galactose oxidase, central domain;
336-374 7.93e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 43.05  E-value: 7.93e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 635172847  336 GGPIYAIGGLDD--NTCFNDVERYDIESDQWSTVAPMNTPR 374
Cdd:pfam13415   1 GDKLYIFGGLGFdgQTRLNDLYVYDLDTNTWTQIGDLPPPR 41
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 88-175 1.07e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 43.80  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  88 FHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVsPQHL-HKLLSSSDLNIENEKQVYNAAIKWLLANP 166
Cdd:cd18451    1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTL-PFHLvRDWLSDAEITVDSEEVLFEAVLKWVQRNA 79


                 ....*....
gi 635172847 167 QHHSKWLDE 175
Cdd:cd18451   80 EERERYFEE 88
muta_rot_YjhT TIGR03547
mutatrotase, YjhT family; Members of this protein family contain multiple copies of the ...
 374-500 7.40e-05

mutatrotase, YjhT family; Members of this protein family contain multiple copies of the beta-propeller-forming Kelch repeat. All are full-length homologs to YjhT of Escherichia coli, which has been identified as a mutarotase for sialic acid. This protein improves bacterial ability to obtain host sialic acid, and thus serves as a virulence factor. Some bacteria carry what appears to be a cyclically permuted homolog of this protein.


Pssm-ID: 274641 [Multi-domain]  Cd Length: 346  Bit Score: 45.01  E-value: 7.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  374 RGGVGsvALVNHVYAVGGNDGMASLSSVERYDPHlDKWIEVKEM-GQRRAGNGVSKLHGCLYVVGGF----DDNSP--LS 446
Cdd:TIGR03547   9 KNGTG--AIIGDKVYVGLGSAGTSWYKLDLKKPS-KGWQKIADFpGGPRNQAVAAAIDGKLYVFGGIgkanSEGSPqvFD 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  447 SVERYDPRSNKWDYVAAlTTPRGGVGIATVM---GKIFAVGGHNG---NAYLNTVEAFDP 500
Cdd:TIGR03547  86 DVYRYDPKKNSWQKLDT-RSPVGLLGASGFSlhnGQAYFTGGVNKnifDGYFADLSAADK 144
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 91-181 1.18e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 41.33  E-value: 1.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847  91 SNCLAVRAFAESHNRIDLMDMADQYACDHFTE-VVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHH 169
Cdd:cd18482    4 SNCAGILKFADAFDNRELKSKALAFIARNFQQlLAKEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANLKER 83

                         90
                 ....*....|..
gi 635172847 170 SKWLDETLAQVR 181
Cdd:cd18482   84 AASAAEVLKCVR 95
PHA03098 PHA03098
kelch-like protein; Provisional
 235-320 2.35e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 43.99  E-value: 2.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 235 TPRKH-------TAGVLFCVGGRGGSGDP--FRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLG 305
Cdd:PHA03098 424 LPISHyggcaiyHDGKIYVIGGISYIDNIkvYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYIN 503

                         90
                 ....*....|....*
gi 635172847 306 SMEMFDPLTNKWMMK 320
Cdd:PHA03098 504 EIEVYDDKTNTWTLF 518
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 420-464 7.90e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 37.32  E-value: 7.90e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 635172847  420 RRAGNGVSKLHGCLYVVGGFDDNSPLSS--VERYDPRSNKWDYVAAL 464
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGDLSSsdVLVYDPETNVWTEVPRL 47
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 92-162 8.05e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 38.94  E-value: 8.05e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 635172847  92 NCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWL 162
Cdd:cd18449    5 NCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWL 75
BACK_KLHL36 cd18475
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act ...
 113-186 8.80e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350550  Cd Length: 100  Bit Score: 38.67  E-value: 8.80e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 635172847 113 DQYACDHFTEVVECEDFV-SVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQ--HHSKWLdetLAQVRLPLLP 186
Cdd:cd18475   26 DSFILQNFGTLSFTPDFLqNVSMQKLCQYLSSNQVQHECEHDLLQAALQWLTQSPEreNEAYQV---LSNIHFPLIP 99
PHA02713 PHA02713
hypothetical protein; Provisional
 331-483 1.06e-03

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 41.92  E-value: 1.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 331 ALASLGGPIYAIGGLD-DNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLD 409
Cdd:PHA02713 298 ASAIVDNEIIIAGGYNfNNPSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDD 377

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 410 KWIEVKEMGQRRAGNGVSKLHGCLYVVGG-----------------FDDNSPLSS-VERYDPRSNKWDYVAALTTPRGGV 471
Cdd:PHA02713 378 KWKMLPDMPIALSSYGMCVLDQYIYIIGGrtehidytsvhhmnsidMEEDTHSSNkVIRYDTVNNIWETLPNFWTGTIRP 457

                        170
                 ....*....|..
gi 635172847 472 GIATVMGKIFAV 483
Cdd:PHA02713 458 GVVSHKDDIYVV 469
Kelch_4 pfam13418
Galactose oxidase, central domain;
339-370 1.43e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.82  E-value: 1.43e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 635172847  339 IYAIGGL-DDNTCFNDVERYDIESDQWSTVAPM 370
Cdd:pfam13418  15 IYLFGGEgEDGTLLSDLWVFDLSTNEWTRLGSL 47
Kelch_6 pfam13964
Kelch motif;
280-327 1.46e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 36.93  E-value: 1.46e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 635172847  280 RRHVGVISVEGKVYAVGG-HDGNEHLGSMEMFDPLTNKWMMKASMNTKR 327
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGyTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 242-277 1.61e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.44  E-value: 1.61e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 635172847  242 GVLFCVGGRGGsGDPFRSIECYSINKNSWFFGPEMN 277
Cdd:pfam01344  12 GKIYVIGGFDG-NQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_3 pfam13415
Galactose oxidase, central domain;
289-335 3.53e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 35.73  E-value: 3.53e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 635172847  289 EGKVYAVGG--HDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASL 335
Cdd:pfam13415   1 GDKLYIFGGlgFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
Kelch_3 pfam13415
Galactose oxidase, central domain;
433-468 3.94e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 35.34  E-value: 3.94e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 635172847  433 LYVVGGFDD--NSPLSSVERYDPRSNKWDYVAALTTPR 468
Cdd:pfam13415   4 LYIFGGLGFdgQTRLNDLYVYDLDTNTWTQIGDLPPPR 41
Kelch_6 pfam13964
Kelch motif;
467-515 6.16e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 35.00  E-value: 6.16e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 635172847  467 PRGGVGIATVMGKIFAVGG-HNGNAYLNTVEAFDPVLNRWELVGSVSHCR 515
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGyTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BACK_KLHL32_BKLHD5 cd18471
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...
 102-185 9.88e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.


Pssm-ID: 350546 [Multi-domain]  Cd Length: 98  Bit Score: 35.65  E-value: 9.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635172847 102 SHNRIDLMDMAD------------QYACDHFTEVVEC--EDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPq 167
Cdd:cd18471    3 SFNYLDLYKLADlfnltlleeavvDFLVKHLSELLKShpEEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLEHNC- 81

                         90
                 ....*....|....*...
gi 635172847 168 hHSKWLDETLAQVRLPLL 185
Cdd:cd18471   82 -RYQYMDELLQYVRFGLM 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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