NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|636526419|ref|NP_001278992|]
View 

otogelin isoform b precursor [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
beta-trefoil_ABD_OTOG cd23400
Arabinose-binding domain (ABD), beta-trefoil fold, found in otogelin (OTOG) and similar ...
 1233-1384 3.05e-84

Arabinose-binding domain (ABD), beta-trefoil fold, found in otogelin (OTOG) and similar proteins; OTOG is a glycoprotein specific to acellular membranes of the inner ear. It may be required for the anchoring of the otoconial membranes and cupula to the underlying neuroepithelia in the vestibule. OTOG may be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. Mutations in the OTOG gene may cause hearing loss. OTOG contains an ABD with a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ABD of the related protein, alpha-L-arabinofuranosidase, binds two arabinose molecules in the beta and gamma subdomains.


:

Pssm-ID: 467810  Cd Length: 152  Bit Score: 272.80  E-value: 3.05e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1233 FFNKVLGKGPYQLSSLAAGGALVGMKAVGDDIVLVRTEDVAPADIVSFLLTAALYKAKAHDPDVVSLEAADRPNFFLHVT 1312
Cdd:cd23400     1 YFNKALGKGPYKLVTYLAGGALLAANKTGGLVFPVRGEDSVDEDLISFMLTPGLYKPKAHDSSLVSFEAADRPNYFLHVG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 636526419 1313 ANGSLELAKWQGRDTFQQHASFLLHRGTRQAGLVALESLAKPSSFLYVSGAVLALRLYEHTEVFRRGTLFRL 1384
Cdd:cd23400    81 ANGSLRLAKWEDSEEFQDRATFVLHRDTWIPGYDALESFAKPGFFLHFMGSALQLQKYEHTERFRRATLFRL 152
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 502-657 4.49e-44

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


:

Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 157.92  E-value: 4.49e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419   502 CSVTGDIHFTTFDGRRYTFPATCQYILAKSRSSGT-FTVTLQNAPCGLNQDGACVQSVSVILhqdPRRQVTLTQAGDVlL 580
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPdFSFSVTNKNCNGGASGVCLKSVTVIV---GDLEITLQKGGTV-L 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 636526419   581 FDQYKIIPPYTDDAFEIRRLSSVFLRVRTNVGVRVLYDREGL-RLYLQVDQRWVEDTVGLCGTFNGNTQDDFLSPVGV 657
Cdd:pfam00094   77 VNGQKVSLPYKSDGGEVEILGSGFVVVDLSPGVGLQVDGDGRgQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 140-290 3.38e-37

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


:

Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 138.27  E-value: 3.38e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419   140 CRAWGQHHVETFDGLYYYLSGKGSYTLVgrHEPEGQS-FSIQVHNDPQCGSSPYTCSRAVSLFfVGEQEIHL--AKEVTH 216
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLA--KDCSEEPdFSFSVTNKNCNGGASGVCLKSVTVI-VGDLEITLqkGGTVLV 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 636526419   217 GGMRVQLPHVMGSARLQQL-AGYVIVRHQSAFTL--AWDGASAVYIKMSPELLGWTHGLCGNNNADPKDDLVTSSGK 290
Cdd:pfam00094   78 NGQKVSLPYKSDGGEVEILgSGFVVVDLSPGVGLqvDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 965-1119 8.62e-36

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


:

Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 134.84  E-value: 8.62e-36
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419    965 CTLHPCASTCTAYGDRHYRTFDGLPFDFVGACKVHLVKS-TSDVSFSVIVENVNCySSGMICRKFISINVGNSLIVFDDD 1043
Cdd:smart00216    3 CTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDcSSEPTFSVLLKNVPC-GGGATCLKSVKVELNGDEIELKDD 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419   1044 ------SGNPSPESFLDDKQEVHTWRVGFFTLVHFPQEHITLLWDQRTTVHVQAGPQWQGQLAGLCGNFDLKTINEMRTP 1117
Cdd:smart00216   82 ngkvtvNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLIQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDFRTP 161


                    ..
gi 636526419   1118 EN 1119
Cdd:smart00216  162 DG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 2100-2254 4.54e-26

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


:

Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 106.30  E-value: 4.54e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  2100 CSIFPDLSFVTFDGSHVALFKEAIYILSQSPDE-MLTVHVLDCKSANLGHLNWppfCLVMLNMTHLAHQVTIDRfNRKVT 2178
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEePDFSFSVTNKNCNGGASGV---CLKSVTVIVGDLEITLQK-GGTVL 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 636526419  2179 VDLQPVWPPVSRYGFRIEDTG-HMYMILTPSDIQIQWLHSS-GLMIVEASKTSKAQGHGLCGICDGDAANDLTLKDGS 2254
Cdd:pfam00094   77 VNGQKVSLPYKSDGGEVEILGsGFVVVDLSPGVGLQVDGDGrGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1154-1228 9.04e-22

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


:

Pssm-ID: 214843  Cd Length: 76  Bit Score: 91.25  E-value: 9.04e-22
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 636526419   1154 EPFAKKECSILLSE--VFEICHPVVDVTWFYSNCLTDTCGCsqGGDCECFCASVSAYAHQCCQHGVAV-DWRTPRLCP 1228
Cdd:smart00832    1 KYYACSQCGILLSPrgPFAACHSVVDPEPFFENCVYDTCAC--GGDCECLCDALAAYAAACAEAGVCIsPWRTPTFCP 76
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 1464-2029 5.43e-21

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 101.94  E-value: 5.43e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1464 LGNETLPPSQGLPTPSDEEPQLSQESPRTPTHRPALTPAAPLTTALNPPVTATEEPVVSP-GPTQTTLQQPLELTASQLP 1542
Cdd:PHA03247 2469 LLGELFPGAPVYRRPAEARFPFAAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDEPVGEPvHPRMLTWIRGLEELASDDA 2548

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1543 AGPTESPASkgvtaslLAIPHTPEsSSLPVALQTPTPgmvSGAMETTRvtvifAGSPNITVSSRSPPAPRFPlmtkavtv 1622
Cdd:PHA03247 2549 GDPPPPLPP-------AAPPAAPD-RSVPPPRPAPRP---SEPAVTSR-----ARRPDAPPQSARPRAPVDD-------- 2604

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1623 RGHGSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAVTKVISRTGVPQPTQAQS-ASSPSTPLTVAG 1701
Cdd:PHA03247 2605 RGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGrAAQASSPPQRPR 2684

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1702 TAAEQVPVSPLATrsleivlstekgeAGHSQPMGSPASPQPHPLPSAPPRPAQHTTMATRSPALP--PETPAAASlSTAT 1779
Cdd:PHA03247 2685 RRAARPTVGSLTS-------------LADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPaaPAPPAVPA-GPAT 2750

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1780 DGLAATPfmslestrPSQLLSGLPPDTSLPLAKVGTSAPVATPGPKASV------ITTPLQPQATTLPAQTLSPVLPFTP 1853
Cdd:PHA03247 2751 PGGPARP--------ARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLsesresLPSPWDPADPPAAVLAPAAALPPAA 2822

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1854 AAMTQAHPPTHIAPPAAGTAPGLLLGATLPTSGVLPVAE----GTASMVSVVPRKSTTGKVAILSK-QVSLPTSMYGSAE 1928
Cdd:PHA03247 2823 SPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDvrrrPPSRSPAAKPAAPARPPVRRLARpAVSRSTESFALPP 2902

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1929 GGPTEL-TPATSHPLTPLVAEPEGAQAGTAL---PVPTSYALSRVSARTAPQDSMLVLLPQL-AEAHGTSAGPHL----A 1999
Cdd:PHA03247 2903 DQPERPpQPQAPPPPQPQPQPPPPPQPQPPPpppPRPQPPLAPTTDPAGAGEPSGAVPQPWLgALVPGRVAVPRFrvpqP 2982

                         570       580       590
                  ....*....|....*....|....*....|
gi 636526419 2000 AEPVDEATTEPSGRSAPALSIVEGLAEALA 2029
Cdd:PHA03247 2983 APSREAPASSTPPLTGHSLSRVSSWASSLA 3012
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 2292-2358 8.08e-16

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


:

Pssm-ID: 214843  Cd Length: 76  Bit Score: 74.30  E-value: 8.08e-16
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 636526419   2292 DCSPCLRMVSNR-TFSACHRFVPPESFCELWIRDT----KYVQQPCVALTVYVAMCHKFHVCIE-WRRSDYCP 2358
Cdd:smart00832    4 ACSQCGILLSPRgPFAACHSVVDPEPFFENCVYDTcacgGDCECLCDALAAYAAACAEAGVCISpWRTPTFCP 76
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 337-400 1.68e-15

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


:

Pssm-ID: 462584  Cd Length: 68  Bit Score: 73.18  E-value: 1.68e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 636526419   337 QCEALLR-PPFDACHAYVSPLPFTASCTSDLCQSMGDVATWCRALAEYARACAQAGRPLQGWRTQ 400
Cdd:pfam08742    1 KCGLLSDsGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTP 65
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 2830-2912 8.89e-14

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


:

Pssm-ID: 214482  Cd Length: 82  Bit Score: 68.97  E-value: 8.89e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419   2830 KVTIRMTIRKNECRSSTpVNLVSCDGRCPSASIYNynINTYARFCKCCREVGLQRRSVQLFCATNATwVPYTVQEPTDCA 2909
Cdd:smart00041    1 KSPVRQTITYNGCTSVT-VKNAFCEGKCGSASSYS--IQDVQHSCSCCQPHKTKTRQVRLRCPDGST-VKKTVMHIEECG 76


                    ...
gi 636526419   2910 CQW 2912
Cdd:smart00041   77 CEP 79
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 701-755 2.40e-10

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


:

Pssm-ID: 462584  Cd Length: 68  Bit Score: 58.55  E-value: 2.40e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 636526419   701 CSVLT-GEMFAPCSAFLSPVPYFEQCRRDACRCG--QPCLCATLAHYAHLCRRHGLPV 755
Cdd:pfam08742    2 CGLLSdSGPFAPCHSVVDPEPYFEACVYDMCSCGgdDECLCAALAAYARACQAAGVCI 59
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 768-832 9.57e-09

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


:

Pssm-ID: 410995  Cd Length: 55  Bit Score: 53.47  E-value: 9.57e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 636526419  768 CEASKEYSPCVAPCGRTCQDLASPEACgvdggddlsRDECVEGCACPPDTYLDTQaDLCVPRNQC 832
Cdd:cd19941     1 CPPNEVYSECGSACPPTCANPNAPPPC---------TKQCVEGCFCPEGYVRNSG-GKCVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 414-462 5.57e-05

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


:

Pssm-ID: 460351  Cd Length: 55  Bit Score: 43.14  E-value: 5.57e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 636526419   414 TYNECIACCPASC---HPRASCvdsEIACVDGCYCPNGLIFEDGG-CVAPAEC 462
Cdd:pfam01826    6 VYSECGSACPPTCanlSPPDVC---PEPCVEGCVCPPGFVRNSGGkCVPPSDC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 2361-2422 6.58e-05

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


:

Pssm-ID: 460351  Cd Length: 55  Bit Score: 42.76  E-value: 6.58e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 636526419  2361 CSSDSTYQACVTACEPpkTCQDGILGPLDPEHCQvlgEGCVCSEGTILHRRHSalCIPEAKC 2422
Cdd:pfam01826    1 CPANEVYSECGSACPP--TCANLSPPDVCPEPCV---EGCVCPPGFVRNSGGK--CVPPSDC 55
NADB_Rossmann super family cl21454
Rossmann-fold NAD(P)(+)-binding proteins; A large family of proteins that share a ...
 2664-2724 2.11e-04

Rossmann-fold NAD(P)(+)-binding proteins; A large family of proteins that share a Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The NADB domain is found in numerous dehydrogenases of metabolic pathways such as glycolysis, and many other redox enzymes. NAD binding involves numerous hydrogen-bonds and van der Waals contacts, in particular H-bonding of residues in a turn between the first strand and the subsequent helix of the Rossmann-fold topology. Characteristically, this turn exhibits a consensus binding pattern similar to GXGXXG, in which the first 2 glycines participate in NAD(P)-binding, and the third facilitates close packing of the helix to the beta-strand. Typically, proteins in this family contain a second domain in addition to the NADB domain, which is responsible for specifically binding a substrate and catalyzing a particular enzymatic reaction.


The actual alignment was detected with superfamily member smart01002:

Pssm-ID: 473865 [Multi-domain]  Cd Length: 149  Bit Score: 44.03  E-value: 2.11e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 636526419   2664 GCAKYECVKAPVCLSRE-LGVMQPGQTVVELSAD--GVCHTSRCTTVLDPltnFYQINTTSVLC 2724
Cdd:smart01002   89 GAVLIPGAKAPKLVTREmVKSMKPGSVIVDVAADqgGCIETSRPTTHDDP---TYVVDGVVHYC 149
VWC_out smart00215
von Willebrand factor (vWF) type C domain;
464-499 2.22e-04

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214565  Cd Length: 67  Bit Score: 41.78  E-value: 2.22e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 636526419    464 CEFHGTLYPPGSVVKEDCNTCTCTSGKWECSTAVCP 499
Cdd:smart00215    1 CWNNGSYYPPGAKWDDDCNRCTCLNGRVSCTKVWCG 36
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 872-934 3.30e-03

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


:

Pssm-ID: 410995  Cd Length: 55  Bit Score: 38.07  E-value: 3.30e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 636526419  872 CPAGQVFVNCSDlhtdlelSRERTCEQqlLNLSVSARGPCLSGCACPQGLLRH-GDACFLPEEC 934
Cdd:cd19941     1 CPPNEVYSECGS-------ACPPTCAN--PNAPPPCTKQCVEGCFCPEGYVRNsGGKCVPPSQC 55
 
Name Accession Description Interval E-value
beta-trefoil_ABD_OTOG cd23400
Arabinose-binding domain (ABD), beta-trefoil fold, found in otogelin (OTOG) and similar ...
 1233-1384 3.05e-84

Arabinose-binding domain (ABD), beta-trefoil fold, found in otogelin (OTOG) and similar proteins; OTOG is a glycoprotein specific to acellular membranes of the inner ear. It may be required for the anchoring of the otoconial membranes and cupula to the underlying neuroepithelia in the vestibule. OTOG may be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. Mutations in the OTOG gene may cause hearing loss. OTOG contains an ABD with a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ABD of the related protein, alpha-L-arabinofuranosidase, binds two arabinose molecules in the beta and gamma subdomains.


Pssm-ID: 467810  Cd Length: 152  Bit Score: 272.80  E-value: 3.05e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1233 FFNKVLGKGPYQLSSLAAGGALVGMKAVGDDIVLVRTEDVAPADIVSFLLTAALYKAKAHDPDVVSLEAADRPNFFLHVT 1312
Cdd:cd23400     1 YFNKALGKGPYKLVTYLAGGALLAANKTGGLVFPVRGEDSVDEDLISFMLTPGLYKPKAHDSSLVSFEAADRPNYFLHVG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 636526419 1313 ANGSLELAKWQGRDTFQQHASFLLHRGTRQAGLVALESLAKPSSFLYVSGAVLALRLYEHTEVFRRGTLFRL 1384
Cdd:cd23400    81 ANGSLRLAKWEDSEEFQDRATFVLHRDTWIPGYDALESFAKPGFFLHFMGSALQLQKYEHTERFRRATLFRL 152
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 502-657 4.49e-44

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 157.92  E-value: 4.49e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419   502 CSVTGDIHFTTFDGRRYTFPATCQYILAKSRSSGT-FTVTLQNAPCGLNQDGACVQSVSVILhqdPRRQVTLTQAGDVlL 580
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPdFSFSVTNKNCNGGASGVCLKSVTVIV---GDLEITLQKGGTV-L 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 636526419   581 FDQYKIIPPYTDDAFEIRRLSSVFLRVRTNVGVRVLYDREGL-RLYLQVDQRWVEDTVGLCGTFNGNTQDDFLSPVGV 657
Cdd:pfam00094   77 VNGQKVSLPYKSDGGEVEILGSGFVVVDLSPGVGLQVDGDGRgQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 491-656 1.52e-42

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 154.10  E-value: 1.52e-42
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419    491 WECSTAVCPAECSVTGDIHFTTFDGRRYTFPATCQYILAKSRSS-GTFTVTLQNAPCGlnQDGACVQSVSVILHQDprrQ 569
Cdd:smart00216    1 WCCTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSePTFSVLLKNVPCG--GGATCLKSVKVELNGD---E 75

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419    570 VTLTQAGDVLLFDQYKIIPPYTDDAFEIRRLSSV-FLRVRTNVGV-RVLYDREGlRLYLQVDQRWVEDTVGLCGTFNGNT 647
Cdd:smart00216   76 IELKDDNGKVTVNGQQVSLPYKTSDGSIQIRSSGgYLVVITSLGLiQVTFDGLT-LLSVQLPSKYRGKTCGLCGNFDGEP 154


                    ....*....
gi 636526419    648 QDDFLSPVG 656
Cdd:smart00216  155 EDDFRTPDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 140-290 3.38e-37

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 138.27  E-value: 3.38e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419   140 CRAWGQHHVETFDGLYYYLSGKGSYTLVgrHEPEGQS-FSIQVHNDPQCGSSPYTCSRAVSLFfVGEQEIHL--AKEVTH 216
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLA--KDCSEEPdFSFSVTNKNCNGGASGVCLKSVTVI-VGDLEITLqkGGTVLV 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 636526419   217 GGMRVQLPHVMGSARLQQL-AGYVIVRHQSAFTL--AWDGASAVYIKMSPELLGWTHGLCGNNNADPKDDLVTSSGK 290
Cdd:pfam00094   78 NGQKVSLPYKSDGGEVEILgSGFVVVDLSPGVGLqvDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 965-1119 8.62e-36

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 134.84  E-value: 8.62e-36
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419    965 CTLHPCASTCTAYGDRHYRTFDGLPFDFVGACKVHLVKS-TSDVSFSVIVENVNCySSGMICRKFISINVGNSLIVFDDD 1043
Cdd:smart00216    3 CTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDcSSEPTFSVLLKNVPC-GGGATCLKSVKVELNGDEIELKDD 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419   1044 ------SGNPSPESFLDDKQEVHTWRVGFFTLVHFPQEHITLLWDQRTTVHVQAGPQWQGQLAGLCGNFDLKTINEMRTP 1117
Cdd:smart00216   82 ngkvtvNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLIQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDFRTP 161


                    ..
gi 636526419   1118 EN 1119
Cdd:smart00216  162 DG 163
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 135-289 1.13e-34

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 131.37  E-value: 1.13e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419    135 ERDSICRAWGQHHVETFDGLYYYLSGKGSYTLVgRHEPEGQSFSIQVHNDPqCGSSPyTCSRAVSLFfVGEQEIHLAK-- 212
Cdd:smart00216    7 ECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLA-QDCSSEPTFSVLLKNVP-CGGGA-TCLKSVKVE-LNGDEIELKDdn 82

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419    213 -EVTHGGMRVQLPHVMGSARLQQLA--GYVIVRHQSA-FTLAWDGASAVYIKMSPELLGWTHGLCGNNNADPKDDLVTSS 288
Cdd:smart00216   83 gKVTVNGQQVSLPYKTSDGSIQIRSsgGYLVVITSLGlIQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDFRTPD 162


                    .
gi 636526419    289 G 289
Cdd:smart00216  163 G 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 974-1120 6.56e-34

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 129.03  E-value: 6.56e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419   974 CTAYGDRHYRTFDGLPFDFVGACKVHLVK---STSDVSFSVIVENVNCYSSGMiCRKFISINVGNSLIVFDDD-----SG 1045
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKdcsEEPDFSFSVTNKNCNGGASGV-CLKSVTVIVGDLEITLQKGgtvlvNG 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 636526419  1046 NPSPESFLDDKQEVHTWRVGFFTLVHFPQEHITLLWDQRTTVHVQAGPQWQGQLAGLCGNFDLKTINEMRTPENL 1120
Cdd:pfam00094   80 QKVSLPYKSDGGEVEILGSGFVVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 2100-2254 4.54e-26

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 106.30  E-value: 4.54e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  2100 CSIFPDLSFVTFDGSHVALFKEAIYILSQSPDE-MLTVHVLDCKSANLGHLNWppfCLVMLNMTHLAHQVTIDRfNRKVT 2178
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEePDFSFSVTNKNCNGGASGV---CLKSVTVIVGDLEITLQK-GGTVL 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 636526419  2179 VDLQPVWPPVSRYGFRIEDTG-HMYMILTPSDIQIQWLHSS-GLMIVEASKTSKAQGHGLCGICDGDAANDLTLKDGS 2254
Cdd:pfam00094   77 VNGQKVSLPYKSDGGEVEILGsGFVVVDLSPGVGLQVDGDGrGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1154-1228 9.04e-22

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 91.25  E-value: 9.04e-22
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 636526419   1154 EPFAKKECSILLSE--VFEICHPVVDVTWFYSNCLTDTCGCsqGGDCECFCASVSAYAHQCCQHGVAV-DWRTPRLCP 1228
Cdd:smart00832    1 KYYACSQCGILLSPrgPFAACHSVVDPEPFFENCVYDTCAC--GGDCECLCDALAAYAAACAEAGVCIsPWRTPTFCP 76
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 2089-2253 9.55e-22

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 94.39  E-value: 9.55e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419   2089 RCCPLWECACRCSIFPDLSFVTFDGSHVALFKEAIYILSQS----PDEMLTVHVLDCKS--ANLGHLNWPPFCLVMLnmt 2162
Cdd:smart00216    1 WCCTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDcssePTFSVLLKNVPCGGgaTCLKSVKVELNGDEIE--- 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419   2163 hlahqvtIDRFNRKVTVDLQPV-WPPVSRYGF-RIEDTGHMYMILTPSDI-QIQWLHSSGLMiVEASKTSKAQGHGLCGI 2239
Cdd:smart00216   78 -------LKDDNGKVTVNGQQVsLPYKTSDGSiQIRSSGGYLVVITSLGLiQVTFDGLTLLS-VQLPSKYRGKTCGLCGN 149

                           170
                    ....*....|....
gi 636526419   2240 CDGDAANDLTLKDG 2253
Cdd:smart00216  150 FDGEPEDDFRTPDG 163
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1464-2029 5.43e-21

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 101.94  E-value: 5.43e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1464 LGNETLPPSQGLPTPSDEEPQLSQESPRTPTHRPALTPAAPLTTALNPPVTATEEPVVSP-GPTQTTLQQPLELTASQLP 1542
Cdd:PHA03247 2469 LLGELFPGAPVYRRPAEARFPFAAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDEPVGEPvHPRMLTWIRGLEELASDDA 2548

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1543 AGPTESPASkgvtaslLAIPHTPEsSSLPVALQTPTPgmvSGAMETTRvtvifAGSPNITVSSRSPPAPRFPlmtkavtv 1622
Cdd:PHA03247 2549 GDPPPPLPP-------AAPPAAPD-RSVPPPRPAPRP---SEPAVTSR-----ARRPDAPPQSARPRAPVDD-------- 2604

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1623 RGHGSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAVTKVISRTGVPQPTQAQS-ASSPSTPLTVAG 1701
Cdd:PHA03247 2605 RGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGrAAQASSPPQRPR 2684

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1702 TAAEQVPVSPLATrsleivlstekgeAGHSQPMGSPASPQPHPLPSAPPRPAQHTTMATRSPALP--PETPAAASlSTAT 1779
Cdd:PHA03247 2685 RRAARPTVGSLTS-------------LADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPaaPAPPAVPA-GPAT 2750

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1780 DGLAATPfmslestrPSQLLSGLPPDTSLPLAKVGTSAPVATPGPKASV------ITTPLQPQATTLPAQTLSPVLPFTP 1853
Cdd:PHA03247 2751 PGGPARP--------ARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLsesresLPSPWDPADPPAAVLAPAAALPPAA 2822

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1854 AAMTQAHPPTHIAPPAAGTAPGLLLGATLPTSGVLPVAE----GTASMVSVVPRKSTTGKVAILSK-QVSLPTSMYGSAE 1928
Cdd:PHA03247 2823 SPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDvrrrPPSRSPAAKPAAPARPPVRRLARpAVSRSTESFALPP 2902

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1929 GGPTEL-TPATSHPLTPLVAEPEGAQAGTAL---PVPTSYALSRVSARTAPQDSMLVLLPQL-AEAHGTSAGPHL----A 1999
Cdd:PHA03247 2903 DQPERPpQPQAPPPPQPQPQPPPPPQPQPPPpppPRPQPPLAPTTDPAGAGEPSGAVPQPWLgALVPGRVAVPRFrvpqP 2982

                         570       580       590
                  ....*....|....*....|....*....|
gi 636526419 2000 AEPVDEATTEPSGRSAPALSIVEGLAEALA 2029
Cdd:PHA03247 2983 APSREAPASSTPPLTGHSLSRVSSWASSLA 3012
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 1485-1948 2.81e-18

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 91.17  E-value: 2.81e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1485 LSQESPRTPTHRPALTPAAPLTTALNPPVTATEepvvspGPTQTTLQQPlELTASQLPAGP-TESPASKGVTASLLA--I 1561
Cdd:pfam17823   42 ASGDAVPRADNKSSEQ*NFCAATAAPAPVTLTK------GTSAAHLNST-EVTAEHTPHGTdLSEPATREGAADGAAsrA 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1562 PHTPESSSLPVALQTPTPGMVSGAMETTRVTVIFAGSPNITVSSRSPpaprfplmtKAVTVRGHgslpvrTTPPQPSLTA 1641
Cdd:pfam17823  115 LAAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAA---------IAAASAPH------AASPAPRTAA 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1642 SPSSRPVASPGAISRSPTSSGSHKAVLTPAVTKVISRTGVPQPTQAQSASSPSTPLTVAGTAAEQV-PVSPLATRSLEIV 1720
Cdd:pfam17823  180 SSTTAASSTTAASSAPTTAASSAPATLTPARGISTAATATGHPAAGTALAAVGNSSPAAGTVTAAVgTVTPAALATLAAA 259

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1721 LSTEKGEAGHSQpMGSPASPQPHPLPSAPprpaqhTTMATRSPALPpetpaaaslstatdglaatpfmslestrpsqlls 1800
Cdd:pfam17823  260 AGTVASAAGTIN-MGDPHARRLSPAKHMP------SDTMARNPAAP---------------------------------- 298

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1801 gLPPDTSLPLAKVGTSAPV--ATPGPKASVITTPLQPQATTLPAQTLSPVLPFT------PAAMTQAHPPTHIAPPAAGT 1872
Cdd:pfam17823  299 -MGAQAQGPIIQVSTDQPVhnTAGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTkaqakePSASPVPVLHTSMIPEVEAT 377

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1873 APGLLLGATLPTSGV----LPVA------EGTASMVSVVPRKSTTGKVAILSKQVSLPtsmygSAEGgptELTPATSHPL 1942
Cdd:pfam17823  378 SPTTQPSPLLPTQGAagpgILLApeqvatEATAGTASAGPTPRSSGDPKTLAMASCQL-----STQG---QYLVVTTDPL 449


                   ....*.
gi 636526419  1943 TPLVAE 1948
Cdd:pfam17823  450 TPALVD 455
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1161-1227 3.37e-17

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 78.19  E-value: 3.37e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 636526419  1161 CSILL-SEVFEICHPVVDVTWFYSNCLTDTCGCsqGGDCECFCASVSAYAHQCCQHGVAV-DWRTPRLC 1227
Cdd:pfam08742    2 CGLLSdSGPFAPCHSVVDPEPYFEACVYDMCSC--GGDDECLCAALAAYARACQAAGVCIgDWRTPTFC 68
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 2292-2358 8.08e-16

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 74.30  E-value: 8.08e-16
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 636526419   2292 DCSPCLRMVSNR-TFSACHRFVPPESFCELWIRDT----KYVQQPCVALTVYVAMCHKFHVCIE-WRRSDYCP 2358
Cdd:smart00832    4 ACSQCGILLSPRgPFAACHSVVDPEPFFENCVYDTcacgGDCECLCDALAAYAAACAEAGVCISpWRTPTFCP 76
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 337-400 1.68e-15

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 73.18  E-value: 1.68e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 636526419   337 QCEALLR-PPFDACHAYVSPLPFTASCTSDLCQSMGDVATWCRALAEYARACAQAGRPLQGWRTQ 400
Cdd:pfam08742    1 KCGLLSDsGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTP 65
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 2830-2912 8.89e-14

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 68.97  E-value: 8.89e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419   2830 KVTIRMTIRKNECRSSTpVNLVSCDGRCPSASIYNynINTYARFCKCCREVGLQRRSVQLFCATNATwVPYTVQEPTDCA 2909
Cdd:smart00041    1 KSPVRQTITYNGCTSVT-VKNAFCEGKCGSASSYS--IQDVQHSCSCCQPHKTKTRQVRLRCPDGST-VKKTVMHIEECG 76


                    ...
gi 636526419   2910 CQW 2912
Cdd:smart00041   77 CEP 79
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 336-400 6.01e-13

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 66.21  E-value: 6.01e-13
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 636526419    336 EQCEALLRP--PFDACHAYVSPLPFTASCTSDLCQSMGDVATWCRALAEYARACAQAGRPLQGWRTQ 400
Cdd:smart00832    6 SQCGILLSPrgPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTP 72
SP2_N cd22540
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins ...
 1471-1883 8.24e-11

N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP2 contains the least conserved DNA-binding domain within the SP subfamily of proteins, and its DNA sequence specificity differs from the other SP proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate, or in some cases, repress expression from different promoters. The transcription factor SP2 serves as a paradigm for indirect genomic binding. It does not require its DNA-binding domain for genomic DNA binding and occupies target promoters independently of whether they contain a cognate DNA-binding motif. SP2 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP2.


Pssm-ID: 411776 [Multi-domain]  Cd Length: 511  Bit Score: 67.26  E-value: 8.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1471 PSQGLpTPSDEEPQLSQESPrtpthrPALTPAAplTTALNPPvtATEEPVVSPGPTQTTLQQPLELTASQLPAGPTESP- 1549
Cdd:cd22540     8 PSEYL-QPAASTTQDSQPSP------LALLAAT--CSKIGPP--AVEAAVTPPAPPQPTPRKLVPIKPAPLPLGPGKNSi 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1550 ---ASKGVT----ASLLAIPHTPesSSLPVALQTPTpgMVSGAMET-TRVTVIFAGSPNITVSSRSP------------P 1609
Cdd:cd22540    77 gflSAKGNIiqlqGSQLSSSAPG--GQQVFAIQNPT--MIIKGSQTrSSTNQQYQISPQIQAAGQINnsgqiqiipgtnQ 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1610 APRFPLMTKAVTVRGHGSLPVRttpPQPSLTASPSSRPVASPGAISRSPtsSGSHKAVLTP-------AVTKVISRTGVP 1682
Cdd:cd22540   153 AIITPVQVLQQPQQAHKPVPIK---PAPLQTSNTNSASLQVPGNVIKLQ--SGGNVALTLPvnnlvgtQDGATQLQLAAA 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1683 QPTQAQSAS-SPSTPLTVAGTAAEQVPVSPLATRSLEIvlstekGEAGHS----QPMGSPASPQPHPLPSAPPRPAQHTt 1757
Cdd:cd22540   228 PSKPSKKIRkKSAQAAQPAVTVAEQVETVLIETTADNI------IQAGNNllivQSPGTGQPAVLQQVQVLQPKQEQQV- 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1758 maTRSPALPPETPAAASLstatdGLAATPfmslesTRPSQllsglppdtslplakvGTSAPVATPGPKASVITTPL-QPQ 1836
Cdd:cd22540   301 --VQIPQQALRVVQAASA-----TLPTVP------QKPLQ----------------NIQIQNSEPTPTQVYIKTPSgEVQ 351

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 636526419 1837 ATTLPAQTLSPVLPFTPAAMTQAHPPTHIAPPAAGTAPGLLLGATLP 1883
Cdd:cd22540   352 TVLLQEAPAATATPSSSTSTVQQQVTANNGTGTSKPNYNVRKERTLP 398
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 701-755 2.40e-10

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 58.55  E-value: 2.40e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 636526419   701 CSVLT-GEMFAPCSAFLSPVPYFEQCRRDACRCG--QPCLCATLAHYAHLCRRHGLPV 755
Cdd:pfam08742    2 CGLLSdSGPFAPCHSVVDPEPYFEACVYDMCSCGgdDECLCAALAAYARACQAAGVCI 59
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 768-832 9.57e-09

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 53.47  E-value: 9.57e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 636526419  768 CEASKEYSPCVAPCGRTCQDLASPEACgvdggddlsRDECVEGCACPPDTYLDTQaDLCVPRNQC 832
Cdd:cd19941     1 CPPNEVYSECGSACPPTCANPNAPPPC---------TKQCVEGCFCPEGYVRNSG-GKCVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 768-832 1.09e-08

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 53.55  E-value: 1.09e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 636526419   768 CEASKEYSPCVAPCGRTCQDLASPEACgvdggddlsRDECVEGCACPPDTYLDTQaDLCVPRNQC 832
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVC---------PEPCVEGCVCPPGFVRNSG-GKCVPPSDC 55
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 699-755 1.66e-08

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 53.50  E-value: 1.66e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 636526419    699 QACSVLTGEM--FAPCSAFLSPVPYFEQCRRDACRCG--QPCLCATLAHYAHLCRRHGLPV 755
Cdd:smart00832    6 SQCGILLSPRgpFAACHSVVDPEPFFENCVYDTCACGgdCECLCDALAAYAAACAEAGVCI 66
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 1427-2019 7.52e-08

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 58.15  E-value: 7.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1427 EGCVPVCPTPQVLDEVTQRCVYLEDCVE---PAVWVPTEALGNETLPPSQGLPTPSDEEPQLSQesprTPTHRP---ALT 1500
Cdd:COG5180    24 PVLSPELWAAANNDAVSQGDRSALASSPtrpYARKIFEPLDIKLALGKPQLPSVAEPEAYLDPA----PPKSSPdtpEEQ 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1501 PAAPLTTALNPPVTATEEpvvSPGPTQTTLQQPLELTASQLPAGPTESPASKGVTASLLAIPHTPESSSLPVALQTPTPG 1580
Cdd:COG5180   100 LGAPAGDLLVLPAAKTPE---LAAGALPAPAAAAALPKAKVTREATSASAGVALAAALLQRSDPILAKDPDGDSASTLPP 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1581 MVSGAMETTRVtvifagsPNITVSSRSPPAPRFPLMTKAvtvrghgslPVRTTPPQPSLTASPSSRPVASPGAISRSPTS 1660
Cdd:COG5180   177 PAEKLDKVLTE-------PRDALKDSPEKLDRPKVEVKD---------EAQEEPPDLTGGADHPRPEAASSPKVDPPSTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1661 SGSHKAVLTPAVTKVISRTGVPQPTQAQSASSPSTP---LTVAGTAAEQVPVSPLAtrslEIVLSTEKGEAGHSQPMGSP 1737
Cdd:COG5180   241 EARSRPATVDAQPEMRPPADAKERRRAAIGDTPAAEppgLPVLEAGSEPQSDAPEA----ETARPIDVKGVASAPPATRP 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1738 ASPQPHPLPSAPPRPAQhttmATRSPALPPEtpaaaslstatdglAATPfmslESTRPsqllSGLPPdtslplakvGTSA 1817
Cdd:COG5180   317 VRPPGGARDPGTPRPGQ----PTERPAGVPE--------------AASD----AGQPP----SAYPP---------AEEA 361

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1818 PVATPGPkasvittPLQPQattlPAQTLSPVLPFTPAAMTQAHPPTHIAPPAAGTAPGLLLGATLPTSGVLPVAEGTASM 1897
Cdd:COG5180   362 VPGKPLE-------QGAPR----PGSSGGDGAPFQPPNGAPQPGLGRRGAPGPPMGAGDLVQAALDGGGRETASLGGAAG 430

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1898 VSVVPRKSTTGKVAIlskqvslptsmygSAEGGPTELTPATSHPLTPLVAEPEgAQAGTALPVPTsyalsrvsartaPQD 1977
Cdd:COG5180   431 GAGQGPKADFVPGDA-------------ESVSGPAGLADQAGAAASTAMADFV-APVTDATPVDV------------ADV 484

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|...
gi 636526419 1978 SMLVLLPQLAEAHGTSAG-PHLAAEPVDEATTEPSGRSAPALS 2019
Cdd:COG5180   485 LGVRPDAILGGNVAPASGlDAETRIIEAEGAPATEDFVAAELS 527
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 414-462 5.57e-05

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 43.14  E-value: 5.57e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 636526419   414 TYNECIACCPASC---HPRASCvdsEIACVDGCYCPNGLIFEDGG-CVAPAEC 462
Cdd:pfam01826    6 VYSECGSACPPTCanlSPPDVC---PEPCVEGCVCPPGFVRNSGGkCVPPSDC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 2361-2422 6.58e-05

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 42.76  E-value: 6.58e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 636526419  2361 CSSDSTYQACVTACEPpkTCQDGILGPLDPEHCQvlgEGCVCSEGTILHRRHSalCIPEAKC 2422
Cdd:pfam01826    1 CPANEVYSECGSACPP--TCANLSPPDVCPEPCV---EGCVCPPGFVRNSGGK--CVPPSDC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 2361-2422 6.64e-05

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 42.69  E-value: 6.64e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 636526419 2361 CSSDSTYQACVTACEPpkTCQDGILGPLDPEHCQvlgEGCVCSEGTILHRRHSalCIPEAKC 2422
Cdd:cd19941     1 CPPNEVYSECGSACPP--TCANPNAPPPCTKQCV---EGCFCPEGYVRNSGGK--CVPPSQC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 414-462 9.46e-05

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 42.30  E-value: 9.46e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 636526419  414 TYNECIACCPASCHPRASCVDSEIACVDGCYCPNGLIFEDGG-CVAPAEC 462
Cdd:cd19941     6 VYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNSGGkCVPPSQC 55
AlaDh_PNT_C smart01002
Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase catalyzes the ...
 2664-2724 2.11e-04

Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase catalyzes the NAD-dependent reversible reductive amination of pyruvate into alanine.


Pssm-ID: 214966 [Multi-domain]  Cd Length: 149  Bit Score: 44.03  E-value: 2.11e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 636526419   2664 GCAKYECVKAPVCLSRE-LGVMQPGQTVVELSAD--GVCHTSRCTTVLDPltnFYQINTTSVLC 2724
Cdd:smart01002   89 GAVLIPGAKAPKLVTREmVKSMKPGSVIVDVAADqgGCIETSRPTTHDDP---TYVVDGVVHYC 149
VWC_out smart00215
von Willebrand factor (vWF) type C domain;
464-499 2.22e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214565  Cd Length: 67  Bit Score: 41.78  E-value: 2.22e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 636526419    464 CEFHGTLYPPGSVVKEDCNTCTCTSGKWECSTAVCP 499
Cdd:smart00215    1 CWNNGSYYPPGAKWDDDCNRCTCLNGRVSCTKVWCG 36
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 1737-1869 3.49e-04

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 45.53  E-value: 3.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1737 PASPQPH--PLPSAPPRPAQHTTMATRSPALPPETPAAASLSTATDGLAATPFMSLESTRPSQLLSGLPPDTSLPLAKVG 1814
Cdd:NF040712  192 FGRPLRPlaTVPRLAREPADARPEEVEPAPAAEGAPATDSDPAEAGTPDDLASARRRRAGVEQPEDEPVGPGAAPAAEPD 271

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 636526419 1815 TSAPVATPGPkASVITTPLQPQATTLPAQTlSPVLPFTPAAMTQAHPPTHIAPPA 1869
Cdd:NF040712  272 EATRDAGEPP-APGAAETPEAAEPPAPAPA-APAAPAAPEAEEPARPEPPPAPKP 324
AbfB pfam05270
Alpha-L-arabinofuranosidase B (ABFB) domain; This family consists of several fungal ...
 1293-1384 9.20e-04

Alpha-L-arabinofuranosidase B (ABFB) domain; This family consists of several fungal alpha-L-arabinofuranosidase B proteins. L-Arabinose is a constituent of plant-cell-wall poly-saccharides. It is found in a polymeric form in L-arabinan, in which the backbone is formed by 1,5-a- linked l-arabinose residues that can be branched via 1,2-a- and 1,3-a-linked l-arabinofuranose side chains. AbfB hydrolyses 1,5-a, 1,3-a and 1,2-a linkages in both oligosaccharides and polysaccharides, which contain terminal non-reducing l-arabinofuranoses in side chains.


Pssm-ID: 428401  Cd Length: 137  Bit Score: 41.76  E-value: 9.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1293 DPDVVSLEAADRPNFFL-HvtANGSLELAKWQGRDTFQQHASFLLHRGTRQAGLVALESLAKPSSFLYVSGAVLALRLYE 1371
Cdd:pfam05270   47 DSGCVSFESVNFPGSYLrH--YNFRLRLDANDGSALFREDATFCPRAGLGDSGSVSLESYNYPGRYIRHYNYELYIDPNG 124

                           90
                   ....*....|...
gi 636526419  1372 HTEVFRRGTLFRL 1384
Cdd:pfam05270  125 GTASFRADATFVV 137
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 2296-2357 9.64e-04

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 40.06  E-value: 9.64e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 636526419  2296 CLRMVSNRTFSACHRFVPPESFCELWIRDT----KYVQQPCVALTVYVAMCHKFHVCIE-WRRSDYC 2357
Cdd:pfam08742    2 CGLLSDSGPFAPCHSVVDPEPYFEACVYDMcscgGDDECLCAALAAYARACQAAGVCIGdWRTPTFC 68
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 872-934 3.30e-03

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 38.07  E-value: 3.30e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 636526419  872 CPAGQVFVNCSDlhtdlelSRERTCEQqlLNLSVSARGPCLSGCACPQGLLRH-GDACFLPEEC 934
Cdd:cd19941     1 CPPNEVYSECGS-------ACPPTCAN--PNAPPPCTKQCVEGCFCPEGYVRNsGGKCVPPSQC 55
Pacifastin_I pfam05375
Pacifastin inhibitor (LCMII); Structures of members of this family show that they are ...
 473-499 6.78e-03

Pacifastin inhibitor (LCMII); Structures of members of this family show that they are comprised of a triple-stranded antiparallel beta-sheet connected by three disulfide bridges, which defines this as a novel family of serine protease inhibitors.


Pssm-ID: 253170  Cd Length: 40  Bit Score: 36.60  E-value: 6.78e-03
                           10        20
                   ....*....|....*....|....*...
gi 636526419   473 PGSVVKEDCNTCTCT-SGKWECSTAVCP 499
Cdd:pfam05375    4 PGSTFKDDCNTCTCTaNGIAACTLKGCP 31
 
Name Accession Description Interval E-value
beta-trefoil_ABD_OTOG cd23400
Arabinose-binding domain (ABD), beta-trefoil fold, found in otogelin (OTOG) and similar ...
 1233-1384 3.05e-84

Arabinose-binding domain (ABD), beta-trefoil fold, found in otogelin (OTOG) and similar proteins; OTOG is a glycoprotein specific to acellular membranes of the inner ear. It may be required for the anchoring of the otoconial membranes and cupula to the underlying neuroepithelia in the vestibule. OTOG may be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. Mutations in the OTOG gene may cause hearing loss. OTOG contains an ABD with a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ABD of the related protein, alpha-L-arabinofuranosidase, binds two arabinose molecules in the beta and gamma subdomains.


Pssm-ID: 467810  Cd Length: 152  Bit Score: 272.80  E-value: 3.05e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1233 FFNKVLGKGPYQLSSLAAGGALVGMKAVGDDIVLVRTEDVAPADIVSFLLTAALYKAKAHDPDVVSLEAADRPNFFLHVT 1312
Cdd:cd23400     1 YFNKALGKGPYKLVTYLAGGALLAANKTGGLVFPVRGEDSVDEDLISFMLTPGLYKPKAHDSSLVSFEAADRPNYFLHVG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 636526419 1313 ANGSLELAKWQGRDTFQQHASFLLHRGTRQAGLVALESLAKPSSFLYVSGAVLALRLYEHTEVFRRGTLFRL 1384
Cdd:cd23400    81 ANGSLRLAKWEDSEEFQDRATFVLHRDTWIPGYDALESFAKPGFFLHFMGSALQLQKYEHTERFRRATLFRL 152
beta-trefoil_ABD_OTOG-like cd23398
Arabinose-binding domain (ABD), beta-trefoil fold, found in the otogelin (OTOG) family; The ...
 1238-1384 1.83e-51

Arabinose-binding domain (ABD), beta-trefoil fold, found in the otogelin (OTOG) family; The OTOG family includes otogelin (OTOG) and otogelin-like protein (OTOGL). OTOG is a glycoprotein specific to acellular membranes of the inner ear. It may be required for the anchoring of the otoconial membranes and cupula to the underlying neuroepithelia in the vestibule. OTOG may be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. OTOGL is a mucin glycoprotein that is a component of the tectorial membrane. It acts as a gel-forming mucin that forms high-molecular-weight complexes and is glycosylated through mucin-type O-glycosylation. Mutations in the OTOG or OTOGL gene may cause hearing loss. Members of this family contain an ABD with a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ABD of the related protein, alpha-L-arabinofuranosidase, binds two arabinose molecules in the beta and gamma subdomains.


Pssm-ID: 467808  Cd Length: 143  Bit Score: 178.67  E-value: 1.83e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1238 LGKGPYQLSSLAAGGALVGMKAVGDDIVLVRTEDVaPADIVSFLLTAALYKAKAhdpDVVSLEAADRPNFFLHVTANGSL 1317
Cdd:cd23398     1 LGEGPYKLSSYNYPGYLLGANDDSGVVSLIPTENS-PSGGVSFMVTPGLNGDKA---NLVSFESAERPNYFLCVQANGTL 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 636526419 1318 ELAKWQGRDTFQQHASFLLHRGTRQAGLVALESLAKPSSFLYVSGAVLALRLYEHTEVFRRGTLFRL 1384
Cdd:cd23398    77 KLVKWENSALFRNAASFFLRQGTWIPGYVAFESTSKPGYFIRHSNSSLKLQKYDHTEEFRRSSSFKL 143
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 502-657 4.49e-44

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 157.92  E-value: 4.49e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419   502 CSVTGDIHFTTFDGRRYTFPATCQYILAKSRSSGT-FTVTLQNAPCGLNQDGACVQSVSVILhqdPRRQVTLTQAGDVlL 580
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEEPdFSFSVTNKNCNGGASGVCLKSVTVIV---GDLEITLQKGGTV-L 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 636526419   581 FDQYKIIPPYTDDAFEIRRLSSVFLRVRTNVGVRVLYDREGL-RLYLQVDQRWVEDTVGLCGTFNGNTQDDFLSPVGV 657
Cdd:pfam00094   77 VNGQKVSLPYKSDGGEVEILGSGFVVVDLSPGVGLQVDGDGRgQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 491-656 1.52e-42

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 154.10  E-value: 1.52e-42
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419    491 WECSTAVCPAECSVTGDIHFTTFDGRRYTFPATCQYILAKSRSS-GTFTVTLQNAPCGlnQDGACVQSVSVILHQDprrQ 569
Cdd:smart00216    1 WCCTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDCSSePTFSVLLKNVPCG--GGATCLKSVKVELNGD---E 75

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419    570 VTLTQAGDVLLFDQYKIIPPYTDDAFEIRRLSSV-FLRVRTNVGV-RVLYDREGlRLYLQVDQRWVEDTVGLCGTFNGNT 647
Cdd:smart00216   76 IELKDDNGKVTVNGQQVSLPYKTSDGSIQIRSSGgYLVVITSLGLiQVTFDGLT-LLSVQLPSKYRGKTCGLCGNFDGEP 154


                    ....*....
gi 636526419    648 QDDFLSPVG 656
Cdd:smart00216  155 EDDFRTPDG 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 140-290 3.38e-37

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 138.27  E-value: 3.38e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419   140 CRAWGQHHVETFDGLYYYLSGKGSYTLVgrHEPEGQS-FSIQVHNDPQCGSSPYTCSRAVSLFfVGEQEIHL--AKEVTH 216
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLA--KDCSEEPdFSFSVTNKNCNGGASGVCLKSVTVI-VGDLEITLqkGGTVLV 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 636526419   217 GGMRVQLPHVMGSARLQQL-AGYVIVRHQSAFTL--AWDGASAVYIKMSPELLGWTHGLCGNNNADPKDDLVTSSGK 290
Cdd:pfam00094   78 NGQKVSLPYKSDGGEVEILgSGFVVVDLSPGVGLqvDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 965-1119 8.62e-36

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 134.84  E-value: 8.62e-36
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419    965 CTLHPCASTCTAYGDRHYRTFDGLPFDFVGACKVHLVKS-TSDVSFSVIVENVNCySSGMICRKFISINVGNSLIVFDDD 1043
Cdd:smart00216    3 CTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDcSSEPTFSVLLKNVPC-GGGATCLKSVKVELNGDEIELKDD 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419   1044 ------SGNPSPESFLDDKQEVHTWRVGFFTLVHFPQEHITLLWDQRTTVHVQAGPQWQGQLAGLCGNFDLKTINEMRTP 1117
Cdd:smart00216   82 ngkvtvNGQQVSLPYKTSDGSIQIRSSGGYLVVITSLGLIQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDFRTP 161


                    ..
gi 636526419   1118 EN 1119
Cdd:smart00216  162 DG 163
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 135-289 1.13e-34

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 131.37  E-value: 1.13e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419    135 ERDSICRAWGQHHVETFDGLYYYLSGKGSYTLVgRHEPEGQSFSIQVHNDPqCGSSPyTCSRAVSLFfVGEQEIHLAK-- 212
Cdd:smart00216    7 ECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLA-QDCSSEPTFSVLLKNVP-CGGGA-TCLKSVKVE-LNGDEIELKDdn 82

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419    213 -EVTHGGMRVQLPHVMGSARLQQLA--GYVIVRHQSA-FTLAWDGASAVYIKMSPELLGWTHGLCGNNNADPKDDLVTSS 288
Cdd:smart00216   83 gKVTVNGQQVSLPYKTSDGSIQIRSsgGYLVVITSLGlIQVTFDGLTLLSVQLPSKYRGKTCGLCGNFDGEPEDDFRTPD 162


                    .
gi 636526419    289 G 289
Cdd:smart00216  163 G 163
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 974-1120 6.56e-34

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 129.03  E-value: 6.56e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419   974 CTAYGDRHYRTFDGLPFDFVGACKVHLVK---STSDVSFSVIVENVNCYSSGMiCRKFISINVGNSLIVFDDD-----SG 1045
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKdcsEEPDFSFSVTNKNCNGGASGV-CLKSVTVIVGDLEITLQKGgtvlvNG 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 636526419  1046 NPSPESFLDDKQEVHTWRVGFFTLVHFPQEHITLLWDQRTTVHVQAGPQWQGQLAGLCGNFDLKTINEMRTPENL 1120
Cdd:pfam00094   80 QKVSLPYKSDGGEVEILGSGFVVVDLSPGVGLQVDGDGRGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
beta-trefoil_ABD_OTOGL cd23401
Arabinose-binding domain (ABD), beta-trefoil fold, found in otogelin-like protein (OTOGL) and ...
 1233-1382 3.90e-26

Arabinose-binding domain (ABD), beta-trefoil fold, found in otogelin-like protein (OTOGL) and similar proteins; OTOGL is a mucin glycoprotein that is a component of the tectorial membrane. It acts as a gel-forming mucin that forms high-molecular-weight complexes and is glycosylated through mucin-type O-glycosylation. Mutations in the OTOGL gene may cause hearing loss. OTOGL contains an ABD with a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ABD of the related protein, alpha-L-arabinofuranosidase, binds two arabinose molecules in the beta and gamma subdomains.


Pssm-ID: 467811  Cd Length: 154  Bit Score: 106.87  E-value: 3.90e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1233 FFNKVLGKGPYQLSSLAAGGALVGMKAVGDDIVLVRTEDVAPADIVSFLLTAALYKAKAHDPDVVSLEAADRPNFFLHVT 1312
Cdd:cd23401     1 YYNQGLGEGPYTLSSYGQSDCVLGANLTSGEVFPLPKISAQGSTFFHFMITPGLFKDKASSLPVVSLESAERPNYFLCVH 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1313 ANGSLELAKWQGRDTFQQHASFLLHRGTRQAGLVALESLAKPSSFLYVSGAVLALRLYEHTEVFRRGTLF 1382
Cdd:cd23401    81 DNRTLRLEQWQPSSEFRRRATFFHHQGLWIPGYSSFELHSKKGFFITLTHSGAKASKYDDSEEFKTSSSF 150
VWD pfam00094
von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is ...
 2100-2254 4.54e-26

von Willebrand factor type D domain; Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.


Pssm-ID: 459671 [Multi-domain]  Cd Length: 154  Bit Score: 106.30  E-value: 4.54e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  2100 CSIFPDLSFVTFDGSHVALFKEAIYILSQSPDE-MLTVHVLDCKSANLGHLNWppfCLVMLNMTHLAHQVTIDRfNRKVT 2178
Cdd:pfam00094    1 CSVSGDPHYVTFDGVKYTFPGTCTYVLAKDCSEePDFSFSVTNKNCNGGASGV---CLKSVTVIVGDLEITLQK-GGTVL 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 636526419  2179 VDLQPVWPPVSRYGFRIEDTG-HMYMILTPSDIQIQWLHSS-GLMIVEASKTSKAQGHGLCGICDGDAANDLTLKDGS 2254
Cdd:pfam00094   77 VNGQKVSLPYKSDGGEVEILGsGFVVVDLSPGVGLQVDGDGrGQLFVTLSPSYQGKTCGLCGNYNGNQEDDFMTPDGT 154
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 1154-1228 9.04e-22

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 91.25  E-value: 9.04e-22
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 636526419   1154 EPFAKKECSILLSE--VFEICHPVVDVTWFYSNCLTDTCGCsqGGDCECFCASVSAYAHQCCQHGVAV-DWRTPRLCP 1228
Cdd:smart00832    1 KYYACSQCGILLSPrgPFAACHSVVDPEPFFENCVYDTCAC--GGDCECLCDALAAYAAACAEAGVCIsPWRTPTFCP 76
VWD smart00216
von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D ...
 2089-2253 9.55e-22

von Willebrand factor (vWF) type D domain; Von Willebrand factor contains several type D domains: D1 and D2 are present within the N-terminal propeptide whereas the remaining D domains are required for multimerisation.


Pssm-ID: 214566 [Multi-domain]  Cd Length: 163  Bit Score: 94.39  E-value: 9.55e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419   2089 RCCPLWECACRCSIFPDLSFVTFDGSHVALFKEAIYILSQS----PDEMLTVHVLDCKS--ANLGHLNWPPFCLVMLnmt 2162
Cdd:smart00216    1 WCCTQEECSPTCSVSGDPHYTTFDGVAYTFPGNCYYVLAQDcssePTFSVLLKNVPCGGgaTCLKSVKVELNGDEIE--- 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419   2163 hlahqvtIDRFNRKVTVDLQPV-WPPVSRYGF-RIEDTGHMYMILTPSDI-QIQWLHSSGLMiVEASKTSKAQGHGLCGI 2239
Cdd:smart00216   78 -------LKDDNGKVTVNGQQVsLPYKTSDGSiQIRSSGGYLVVITSLGLiQVTFDGLTLLS-VQLPSKYRGKTCGLCGN 149

                           170
                    ....*....|....
gi 636526419   2240 CDGDAANDLTLKDG 2253
Cdd:smart00216  150 FDGEPEDDFRTPDG 163
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1464-2029 5.43e-21

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 101.94  E-value: 5.43e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1464 LGNETLPPSQGLPTPSDEEPQLSQESPRTPTHRPALTPAAPLTTALNPPVTATEEPVVSP-GPTQTTLQQPLELTASQLP 1542
Cdd:PHA03247 2469 LLGELFPGAPVYRRPAEARFPFAAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDEPVGEPvHPRMLTWIRGLEELASDDA 2548

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1543 AGPTESPASkgvtaslLAIPHTPEsSSLPVALQTPTPgmvSGAMETTRvtvifAGSPNITVSSRSPPAPRFPlmtkavtv 1622
Cdd:PHA03247 2549 GDPPPPLPP-------AAPPAAPD-RSVPPPRPAPRP---SEPAVTSR-----ARRPDAPPQSARPRAPVDD-------- 2604

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1623 RGHGSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAVTKVISRTGVPQPTQAQS-ASSPSTPLTVAG 1701
Cdd:PHA03247 2605 RGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGrAAQASSPPQRPR 2684

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1702 TAAEQVPVSPLATrsleivlstekgeAGHSQPMGSPASPQPHPLPSAPPRPAQHTTMATRSPALP--PETPAAASlSTAT 1779
Cdd:PHA03247 2685 RRAARPTVGSLTS-------------LADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPaaPAPPAVPA-GPAT 2750

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1780 DGLAATPfmslestrPSQLLSGLPPDTSLPLAKVGTSAPVATPGPKASV------ITTPLQPQATTLPAQTLSPVLPFTP 1853
Cdd:PHA03247 2751 PGGPARP--------ARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLsesresLPSPWDPADPPAAVLAPAAALPPAA 2822

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1854 AAMTQAHPPTHIAPPAAGTAPGLLLGATLPTSGVLPVAE----GTASMVSVVPRKSTTGKVAILSK-QVSLPTSMYGSAE 1928
Cdd:PHA03247 2823 SPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDvrrrPPSRSPAAKPAAPARPPVRRLARpAVSRSTESFALPP 2902

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1929 GGPTEL-TPATSHPLTPLVAEPEGAQAGTAL---PVPTSYALSRVSARTAPQDSMLVLLPQL-AEAHGTSAGPHL----A 1999
Cdd:PHA03247 2903 DQPERPpQPQAPPPPQPQPQPPPPPQPQPPPpppPRPQPPLAPTTDPAGAGEPSGAVPQPWLgALVPGRVAVPRFrvpqP 2982

                         570       580       590
                  ....*....|....*....|....*....|
gi 636526419 2000 AEPVDEATTEPSGRSAPALSIVEGLAEALA 2029
Cdd:PHA03247 2983 APSREAPASSTPPLTGHSLSRVSSWASSLA 3012
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1455-1943 6.81e-21

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 101.94  E-value: 6.81e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1455 PAVWVPTEALGNETLPPSQGLPTPSdeEPQLsqespRTPTHRPALTPAAplttalNPPVTATEEPVVSPGPTQTTLQQPl 1534
Cdd:PHA03247 2554 PLPPAAPPAAPDRSVPPPRPAPRPS--EPAV-----TSRARRPDAPPQS------ARPRAPVDDRGDPRGPAPPSPLPP- 2619

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1535 eltASQLPAGPTESPASKgvtASLLAIPHTPESSSLPVALQTPTPGMVSGAMETTRVTVifAGSPNITVSSRSPPAPRFP 1614
Cdd:PHA03247 2620 ---DTHAPDPPPPSPSPA---ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGR--AAQASSPPQRPRRRAARPT 2691

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1615 LMTKAVTVRGHGSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAVTKVISRTgVPQPTQAQSASSPS 1694
Cdd:PHA03247 2692 VGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPAR-PARPPTTAGPPAPA 2770

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1695 TPLTVAGTAAEQVPVSPLATRSleivlstekgEAGHSQPmgSPASPQPHPLPSAPPRPAQhTTMATRSPALPPETPAAAS 1774
Cdd:PHA03247 2771 PPAAPAAGPPRRLTRPAVASLS----------ESRESLP--SPWDPADPPAAVLAPAAAL-PPAASPAGPLPPPTSAQPT 2837

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1775 LSTATDGLAATPFMSLESTRPSQLLSGLPPDTSLPlakvgtSAPVATPGPKASVITTP-LQPQATTLPAQTLSPVLPFTP 1853
Cdd:PHA03247 2838 APPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPA------AKPAAPARPPVRRLARPaVSRSTESFALPPDQPERPPQP 2911

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1854 AAMTQAHPPTHIAPPAAGT----APGLLLGATLPTSGVLPVAEGTASMVSVVPRKSTTGKVAILSKQVSLPTsmygsaeg 1929
Cdd:PHA03247 2912 QAPPPPQPQPQPPPPPQPQppppPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA-------- 2983

                         490
                  ....*....|....*
gi 636526419 1930 gPTELTPATS-HPLT 1943
Cdd:PHA03247 2984 -PSREAPASStPPLT 2997
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 1485-1948 2.81e-18

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 91.17  E-value: 2.81e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1485 LSQESPRTPTHRPALTPAAPLTTALNPPVTATEepvvspGPTQTTLQQPlELTASQLPAGP-TESPASKGVTASLLA--I 1561
Cdd:pfam17823   42 ASGDAVPRADNKSSEQ*NFCAATAAPAPVTLTK------GTSAAHLNST-EVTAEHTPHGTdLSEPATREGAADGAAsrA 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1562 PHTPESSSLPVALQTPTPGMVSGAMETTRVTVIFAGSPNITVSSRSPpaprfplmtKAVTVRGHgslpvrTTPPQPSLTA 1641
Cdd:pfam17823  115 LAAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAA---------IAAASAPH------AASPAPRTAA 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1642 SPSSRPVASPGAISRSPTSSGSHKAVLTPAVTKVISRTGVPQPTQAQSASSPSTPLTVAGTAAEQV-PVSPLATRSLEIV 1720
Cdd:pfam17823  180 SSTTAASSTTAASSAPTTAASSAPATLTPARGISTAATATGHPAAGTALAAVGNSSPAAGTVTAAVgTVTPAALATLAAA 259

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1721 LSTEKGEAGHSQpMGSPASPQPHPLPSAPprpaqhTTMATRSPALPpetpaaaslstatdglaatpfmslestrpsqlls 1800
Cdd:pfam17823  260 AGTVASAAGTIN-MGDPHARRLSPAKHMP------SDTMARNPAAP---------------------------------- 298

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1801 gLPPDTSLPLAKVGTSAPV--ATPGPKASVITTPLQPQATTLPAQTLSPVLPFT------PAAMTQAHPPTHIAPPAAGT 1872
Cdd:pfam17823  299 -MGAQAQGPIIQVSTDQPVhnTAGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTkaqakePSASPVPVLHTSMIPEVEAT 377

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1873 APGLLLGATLPTSGV----LPVA------EGTASMVSVVPRKSTTGKVAILSKQVSLPtsmygSAEGgptELTPATSHPL 1942
Cdd:pfam17823  378 SPTTQPSPLLPTQGAagpgILLApeqvatEATAGTASAGPTPRSSGDPKTLAMASCQL-----STQG---QYLVVTTDPL 449


                   ....*.
gi 636526419  1943 TPLVAE 1948
Cdd:pfam17823  450 TPALVD 455
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 1161-1227 3.37e-17

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 78.19  E-value: 3.37e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 636526419  1161 CSILL-SEVFEICHPVVDVTWFYSNCLTDTCGCsqGGDCECFCASVSAYAHQCCQHGVAV-DWRTPRLC 1227
Cdd:pfam08742    2 CGLLSdSGPFAPCHSVVDPEPYFEACVYDMCSC--GGDDECLCAALAAYARACQAAGVCIgDWRTPTFC 68
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1507-1963 7.99e-16

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 84.58  E-value: 7.99e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1507 TALNPpVTATEEPVVSPGPTQTTLQQPLELTASQLPAGPTESPASKGVTASLLAIPHT-PESSSLPVAlqTPTP-GMVSG 1584
Cdd:pfam05109  408 TATNA-TTTTHKVIFSKAPESTTTSPTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTgPTVSTADVT--SPTPaGTTSG 484

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1585 AMETTRvtvifagSPNITVSSRSPPAPRFPLMTKAVTV---RGHGSLPVRTTPP----QPSLTASPSSRPVASPGAISRS 1657
Cdd:pfam05109  485 ASPVTP-------SPSPRDNGTESKAPDMTSPTSAVTTptpNATSPTPAVTTPTpnatSPTLGKTSPTSAVTTPTPNATS 557

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1658 PTSsgshkAVLTPAVTKVISRTGVPQPTQAQSASSPSTPLTVAGTAAEQVPVSplatrsleivlstekgeaghSQPMGSP 1737
Cdd:pfam05109  558 PTP-----AVTTPTPNATIPTLGKTSPTSAVTTPTPNATSPTVGETSPQANTT--------------------NHTLGGT 612

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1738 ASPqphPLPSAPPRPA-------QH--TTMATRSPALPPETPAAA-SLSTATDGLAATPFMSLESTRPSQLLSGLPPdTS 1807
Cdd:pfam05109  613 SST---PVVTSPPKNAtsavttgQHniTSSSTSSMSLRPSSISETlSPSTSDNSTSHMPLLTSAHPTGGENITQVTP-AS 688

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1808 LPLAKVGTSAPVATPGpKASVITTPLQPQATTLPAQTlspvlpftpaAMTQAHPPTHIAPPAAGTAPGLLLGATLPTSGV 1887
Cdd:pfam05109  689 TSTHHVSTSSPAPRPG-TTSQASGPGNSSTSTKPGEV----------NVTKGTPPKNATSPQAPSGQKTAVPTVTSTGGK 757

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1888 LPVAEGTasmvsvvprKSTTGKVAILSKQvslPTSMYGSAEGGP-------TELTPATSHPLTP--LVAEPEGAQAGTAL 1958
Cdd:pfam05109  758 ANSTTGG---------KHTTGHGARTSTE---PTTDYGGDSTTPrtrynatTYLPPSTSSKLRPrwTFTSPPVTTAQATV 825


                   ....*
gi 636526419  1959 PVPTS 1963
Cdd:pfam05109  826 PVPPT 830
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 2292-2358 8.08e-16

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 74.30  E-value: 8.08e-16
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 636526419   2292 DCSPCLRMVSNR-TFSACHRFVPPESFCELWIRDT----KYVQQPCVALTVYVAMCHKFHVCIE-WRRSDYCP 2358
Cdd:smart00832    4 ACSQCGILLSPRgPFAACHSVVDPEPFFENCVYDTcacgGDCECLCDALAAYAAACAEAGVCISpWRTPTFCP 76
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 337-400 1.68e-15

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 73.18  E-value: 1.68e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 636526419   337 QCEALLR-PPFDACHAYVSPLPFTASCTSDLCQSMGDVATWCRALAEYARACAQAGRPLQGWRTQ 400
Cdd:pfam08742    1 KCGLLSDsGPFAPCHSVVDPEPYFEACVYDMCSCGGDDECLCAALAAYARACQAAGVCIGDWRTP 65
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1469-1840 3.26e-15

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 82.27  E-value: 3.26e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1469 LPPSQGLPT----PSDEEPQLSQESPRTPTHRPALTPAAPLTTALNPPVTATEEPVVSPGPTQTTLQQPLELTASQLPAG 1544
Cdd:pfam05109  448 LPSSTHVPTnltaPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAV 527

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1545 PTESPASKGVT------ASLLAIPhTPESSSLPVALQTPTPGMVSGAM-ETTRVTVIFAGSPNITVSSRSPPAPRfpLMT 1617
Cdd:pfam05109  528 TTPTPNATSPTlgktspTSAVTTP-TPNATSPTPAVTTPTPNATIPTLgKTSPTSAVTTPTPNATSPTVGETSPQ--ANT 604

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1618 KAVTVRGHGSLPVRTTPP----------QPSLTASPSSRPVASPGAISR--SPTSSG---SHKAVLTPAvtkviSRTGVP 1682
Cdd:pfam05109  605 TNHTLGGTSSTPVVTSPPknatsavttgQHNITSSSTSSMSLRPSSISEtlSPSTSDnstSHMPLLTSA-----HPTGGE 679

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1683 QPTQAQSAS------SPSTPLTVAGTAAEQVPVSPLATrsleivlSTEKGEAGHSQpmGSPasPQPHPLPSAPprpaqht 1756
Cdd:pfam05109  680 NITQVTPAStsthhvSTSSPAPRPGTTSQASGPGNSST-------STKPGEVNVTK--GTP--PKNATSPQAP------- 741

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1757 tmATRSPALPPETPAAASLSTATDGLAATPFMSLESTRPSQLLSG--------------LPPDTSLPLAK--VGTSAPVA 1820
Cdd:pfam05109  742 --SGQKTAVPTVTSTGGKANSTTGGKHTTGHGARTSTEPTTDYGGdsttprtrynattyLPPSTSSKLRPrwTFTSPPVT 819

                          410       420
                   ....*....|....*....|.
gi 636526419  1821 TpgPKASVITTPL-QPQATTL 1840
Cdd:pfam05109  820 T--AQATVPVPPTsQPRFSNL 838
PHA03378 PHA03378
EBNA-3B; Provisional
 1481-1962 2.53e-14

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 79.73  E-value: 2.53e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1481 EEPQLSQESPRTPTHRPALTPAAPLTTALNPPVTATEEPVVSPG-PTQTTLQQPLelTASQLPAGPTESPASKGVTA--S 1557
Cdd:PHA03378  427 EEEHRKKKAARTEQPRATPHSQAPTVVLHRPPTQPLEGPTGPLSvQAPLEPWQPL--PHPQVTPVILHQPPAQGVQAhgS 504

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1558 LLAIPHTPESSSLPVALQTPTPGMVSGAMETTRVTVIFAGSPNItvsSRSPPAPRFPLMTKAVTVRGHGSLPVR--TTPP 1635
Cdd:PHA03378  505 MLDLLEKDDEDMEQRVMATLLPPSPPQPRAGRRAPCVYTEDLDI---ESDEPASTEPVHDQLLPAPGLGPLQIQplTSPT 581

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1636 QPSL-TASPS----SRPVASPGAISRSPTSSGSHKAVLTPAVTKVISRTGVPQPTQAQSAS-------SPSTPLTVAGTA 1703
Cdd:PHA03378  582 TSQLaSSAPSyaqtPWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPLRPIPMRPLRMQPITfnvlvfpTPHQPPQVEITP 661

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1704 AE-------QVPVSPLATRSLEIVLSteKGEAGHSQPmgSPASPQPHPLPSAPPRPAQHTTMATRSPALPPETPAAASLS 1776
Cdd:PHA03378  662 YKptwtqigHIPYQPSPTGANTMLPI--QWAPGTMQP--PPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPP 737

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1777 TATDGLAATPFMSLESTRPSQLLSG-LPPDTSLPLAKVGTSAPVATPGPKASVITTPL-QPQATTLPAqtlsPVLPFTPA 1854
Cdd:PHA03378  738 AAAPGRARPPAAAPGRARPPAAAPGrARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTpQPPPQAGPT----SMQLMPRA 813

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1855 AMTQAHPPTHIAP----------------PAAGTAPGLLLGATLPTSGVL------PVAEGTASMVSVVPRKSTTGKVAI 1912
Cdd:PHA03378  814 APGQQGPTKQILRqlltggvkrgrpslkkPAALERQAAAGPTPSPGSGTSdkivqaPVFYPPVLQPIQVMRQLGSVRAAA 893

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 636526419 1913 LSKQVSLPTSMYGSAEGG----PTELTPaTSHPLTPLVAEPEGAQAGtALPVPT 1962
Cdd:PHA03378  894 ASTVTQAPTEYTGERRGVgpmhPTDIPP-SKRAKTDAYVESQPPHGG-QSHSFS 945
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 1459-1835 2.78e-14

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 78.46  E-value: 2.78e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1459 VPTEALGNETLPPSQGLPTPSDEEPQLSQESPRTPthrpalTPAAPLTTALNPPVTATEEPVVSpgpTQTTLQQPLELTA 1538
Cdd:pfam17823  114 ALAAAASSSPSSAAQSLPAAIAALPSEAFSAPRAA------ACRANASAAPRAAIAAASAPHAA---SPAPRTAASSTTA 184

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1539 SQLPAGPTESPASKGVTASLLAIPHTPESSSlPVALQTPTPGMVSGAMETTRVTvifAGSPNITVSSRSpPAPRFPLMTK 1618
Cdd:pfam17823  185 ASSTTAASSAPTTAASSAPATLTPARGISTA-ATATGHPAAGTALAAVGNSSPA---AGTVTAAVGTVT-PAALATLAAA 259

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1619 AVTV-----RGHGSLPVRTTP-PQPSLTASPSSR-PVASPGAISRSPTSSGShkaVLTPavtkVISRTGVPQPTQAQSAS 1691
Cdd:pfam17823  260 AGTVasaagTINMGDPHARRLsPAKHMPSDTMARnPAAPMGAQAQGPIIQVS---TDQP----VHNTAGEPTPSPSNTTL 332

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1692 SPSTPLTVAGTaaeqvpvsplatrSLEIVLSTEkgeaghSQPMGSPASPQPHPLPSAPPRPAQHTTMATRSPALPPETPA 1771
Cdd:pfam17823  333 EPNTPKSVAST-------------NLAVVTTTK------AQAKEPSASPVPVLHTSMIPEVEATSPTTQPSPLLPTQGAA 393

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 636526419  1772 AASLSTATDGLAATPFMSLESTRPSQLLSGLPPDTSLplakvgTSAPVATPGPKASVITTPLQP 1835
Cdd:pfam17823  394 GPGILLAPEQVATEATAGTASAGPTPRSSGDPKTLAM------ASCQLSTQGQYLVVTTDPLTP 451
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1467-1868 2.88e-14

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 79.98  E-value: 2.88e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1467 ETLPPSQGLPTPSDEEPQLSQESPRTPTHRPAlTPAAPLTTALNPPVTATEEPVVSPGPTQTtlqqplelTASQLPAGP- 1545
Cdd:PHA03247 2709 EPAPHALVSATPLPPGPAAARQASPALPAAPA-PPAVPAGPATPGGPARPARPPTTAGPPAP--------APPAAPAAGp 2779

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1546 ---TESPASKGVTASLLAIPHTPESSSLPVALQTPTPGMVSGAMETTRVTVIFAGSPnitVSSRSPPAPRFPLMTKAVTV 1622
Cdd:PHA03247 2780 prrLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQP---TAPPPPPGPPPPSLPLGGSV 2856

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1623 RGHGSL----PVRTTPPQPSLTASPSSRPVASPgAISRSPTSSGSHKAVLTPAVTKVISRTGVPQPtQAQSASSPSTPLT 1698
Cdd:PHA03247 2857 APGGDVrrrpPSRSPAAKPAAPARPPVRRLARP-AVSRSTESFALPPDQPERPPQPQAPPPPQPQP-QPPPPPQPQPPPP 2934

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1699 VAGTAAEQVPVSPLATRSLEIVLSTEKGEAGHSQPmGSPASPQPHPLPSAPPRPAqhttmatrsPALPPETPAAASLSTA 1778
Cdd:PHA03247 2935 PPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVP-GRVAVPRFRVPQPAPSREA---------PASSTPPLTGHSLSRV 3004

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1779 TDGLAATPFMSLESTRPSQLLSGLPPDTSLPLAKvGTSAPVATPGPKASVITTPLQPQATTLPAQtlsPVLPFTPAAMTQ 1858
Cdd:PHA03247 3005 SSWASSLALHEETDPPPVSLKQTLWPPDDTEDSD-ADSLFDSDSERSDLEALDPLPPEPHDPFAH---EPDPATPEAGAR 3080

                         410
                  ....*....|
gi 636526419 1859 AHPPTHIAPP 1868
Cdd:PHA03247 3081 ESPSSQFGPP 3090
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1466-1869 4.28e-14

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 79.04  E-value: 4.28e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1466 NETLPPSqgLPTPSDEEPQL--SQESPRTPTHRPALTPAAPLTTALNPPVTA-TEEPVVSPGPTQTTLQQPLELTASQLP 1542
Cdd:pfam03154  141 NRSTSPS--IPSPQDNESDSdsSAQQQILQTQPPVLQAQSGAASPPSPPPPGtTQAATAGPTPSAPSVPPQGSPATSQPP 218

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1543 AGPtESPAskgvtASLLAIPHTPesSSLPVALQTPTPGMVSGAMETTRVTVIFAGSPNITVSSRSPPAPRF-----PLMT 1617
Cdd:pfam03154  219 NQT-QSTA-----APHTLIQQTP--TLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSlqtgpSHMQ 290

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1618 KAVTVRGHGSLPVRT---TPPQPSLTAS-PSSRPVASPGAISRSPTSSGSHKAVLTPAV-----TKVISRTGVPQPTQAQ 1688
Cdd:pfam03154  291 HPVPPQPFPLTPQSSqsqVPPGPSPAAPgQSQQRIHTPPSQSQLQSQQPPREQPLPPAPlsmphIKPPPTTPIPQLPNPQ 370

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1689 SASSPStplTVAGTAAEQVPVS---PLATRSLEiVLSTEKGEAGHSQPMgsPASPQPHPLPSAPPRPAqhttMATRSPAL 1765
Cdd:pfam03154  371 SHKHPP---HLSGPSPFQMNSNlppPPALKPLS-SLSTHHPPSAHPPPL--QLMPQSQQLPPPPAQPP----VLTQSQSL 440

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1766 PPETPAAASLSTATDGLAATPF--MSLESTRPSQLLSGLPPDTSLPLAKVG----TSAPVATPGPKASVITTPLQP---- 1835
Cdd:pfam03154  441 PPPAASHPPTSGLHQVPSQSPFpqHPFVPGGPPPITPPSGPPTSTSSAMPGiqppSSASVSSSGPVPAAVSCPLPPvqik 520

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 636526419  1836 -QATTLPAQTLSPvlpfTPAAMTQAHPPTHIAPPA 1869
Cdd:pfam03154  521 eEALDEAEEPESP----PPPPRSPSPEPTVVNTPS 551
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 2830-2912 8.89e-14

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 68.97  E-value: 8.89e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419   2830 KVTIRMTIRKNECRSSTpVNLVSCDGRCPSASIYNynINTYARFCKCCREVGLQRRSVQLFCATNATwVPYTVQEPTDCA 2909
Cdd:smart00041    1 KSPVRQTITYNGCTSVT-VKNAFCEGKCGSASSYS--IQDVQHSCSCCQPHKTKTRQVRLRCPDGST-VKKTVMHIEECG 76


                    ...
gi 636526419   2910 CQW 2912
Cdd:smart00041   77 CEP 79
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 336-400 6.01e-13

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 66.21  E-value: 6.01e-13
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 636526419    336 EQCEALLRP--PFDACHAYVSPLPFTASCTSDLCQSMGDVATWCRALAEYARACAQAGRPLQGWRTQ 400
Cdd:smart00832    6 SQCGILLSPrgPFAACHSVVDPEPFFENCVYDTCACGGDCECLCDALAAYAAACAEAGVCISPWRTP 72
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1438-1824 2.20e-12

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 73.28  E-value: 2.20e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1438 VLDEVTQRCVYLEDCVEPAVWVPTEALGNETLPPSQGLPTPSDEEPQLSQESPRTPTHRPALTPAAPLTTALNPPVTATE 1517
Cdd:PHA03307   54 TVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPD 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1518 -----EPVVSPGPTQTTLQQPLELTASQLPAGPTESPASKGVTASLLAIPHTPESSSLPVALQTPTPGMVSGAMETTRVT 1592
Cdd:PHA03307  134 lsemlRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPI 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1593 VIFAGSPnitvSSRSPPAPRFPLMTKAVTV-----RGHGSLPVRTTP-PQPSLTASPSSRPVASPGAISRSPTSSGShka 1666
Cdd:PHA03307  214 SASASSP----APAPGRSAADDAGASSSDSsssesSGCGWGPENECPlPRPAPITLPTRIWEASGWNGPSSRPGPAS--- 286

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1667 vltpavtkviSRTGVPQPTQAQSASSPSTPLTVAGTAA--EQVPVSPLATRSleivlSTEKGEAGHSQPMGSPASPQPHP 1744
Cdd:PHA03307  287 ----------SSSSPRERSPSPSPSSPGSGPAPSSPRAssSSSSSRESSSSS-----TSSSSESSRGAAVSPGPSPSRSP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1745 LPSAPPRPAQHTTMATRSPALPPETPAAASLSTAT--DGLAATPFMSLESTRPSQLLSGLPPdtSLPLAKVGTSAPVATP 1822
Cdd:PHA03307  352 SPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTrrRARAAVAGRARRRDATGRFPAGRPR--PSPLDAGAASGAFYAR 429


                  ..
gi 636526419 1823 GP 1824
Cdd:PHA03307  430 YP 431
beta-trefoil_ABD_ABFB-like cd23265
Arabinose-binding domain (ABD), beta-trefoil fold, found in the ABFB family; The ABFB family ...
 1238-1378 3.74e-12

Arabinose-binding domain (ABD), beta-trefoil fold, found in the ABFB family; The ABFB family includes alpha-L-arabinofuranosidase B (ABF B)-like proteins and otogelin-like proteins. Alpha-L-arabinofuranosidase (EC 3.2.1.55), also called ABF, or non-reducing end alpha-L-arabinofuranosidase, or arabinofuranosidase, or arabinosidase, is involved in the degradation of arabinoxylan, a major component of plant hemicellulose. It can hydrolyze 1,5-, 1,3- and 1,2-alpha-linkages not only in L-arabinofuranosyl oligosaccharides, but also in polysaccharides containing terminal non-reducing L-arabinofuranoses in side chains, like L-arabinan, arabinogalactan and arabinoxylan. ABF belongs to the glycosyl hydrolase 54 family. Hungateiclostridium thermocellum anti-sigma-I factor RsgI5 shows high sequence similarity with ABF B. It negatively regulates SigI5 activity through direct interaction. The OTOG subfamily includes otogelin (OTOG) and otogelin-like protein (OTOGL). OTOG is a glycoprotein specific to acellular membranes of the inner ear. It may be required for the anchoring of otoconial membranes and cupula to the underlying neuroepithelia in the vestibule. OTOG may be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. OTOGL is a mucin glycoprotein that is a component of the tectorial membrane. It acts as a gel-forming mucin that forms high-molecular-weight complexes and is glycosylated through mucin-type O-glycosylation. Mutations in OTOG or OTOGL genes may cause hearing loss. Members of the ABFB family contain an ABD with a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ABD binds two arabinose molecules in the beta and gamma subdomains.


Pssm-ID: 467807  Cd Length: 135  Bit Score: 66.15  E-value: 3.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1238 LGKGPYQLSSLAAGGALVGmkaVGDDIVLVRTEDVAPADIVSFLLTAALYkakahDPDVVSLEAADRPNFFLHVtANGSL 1317
Cdd:cd23265     1 DGGTPVRLRSASDPGYYIR---HDGGSGSVTSDDDDSAEDAFFRVVPGLA-----GEGTVSFESVDKPGYYLRH-RGGEL 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 636526419 1318 ELAKWQGRDTFQQHASFLLHRGTRQAGLVALESLAKPSSFLYVSGAVLALRlYEHTEVFRR 1378
Cdd:cd23265    72 RLEKNDGSAAFREDATFRPRPGLADPGGVSFESVNYPGYYLRHRNNRLVLG-KVDSTAFKE 131
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 1610-2017 9.52e-12

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 71.17  E-value: 9.52e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1610 APRFPLMTKAVTVRGHGSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAvtkvisrtgvPQPTQAQS 1689
Cdd:PRK07764  375 LARLERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPA----------PAPAPPSP 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1690 ASSPSTPLTVAGTAAEQVPVSPlatrsleivlsTEKGEAGHSQPMGSPASPQPHPLPSAPPRPAQHTtmATRSPALPPET 1769
Cdd:PRK07764  445 AGNAPAGGAPSPPPAAAPSAQP-----------APAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAP--AAPAGADDAAT 511

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1770 P------------------AAASLSTAT----DG----LA-ATPFM--SLESTRPSQLLSGLppdtslpLAKV--GTSAP 1818
Cdd:PRK07764  512 LrerwpeilaavpkrsrktWAILLPEATvlgvRGdtlvLGfSTGGLarRFASPGNAEVLVTA-------LAEElgGDWQV 584

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1819 VATPGPKASvittPLQPQATTLPAQTLSPVLPFTPAAMTQAHPPTHIAPPAAGTAPGLLLGATLPTSGVLPVAEGTASMV 1898
Cdd:PRK07764  585 EAVVGPAPG----AAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVP 660

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1899 SVVPRKSTTGKVAILSKQVSLPTSMYGSAEGGPTELTPATSHPLTPLVAEPEGAQAGTALPVPTSYALSRVSARTAPQds 1978
Cdd:PRK07764  661 DASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDP-- 738

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 636526419 1979 mlVLLPQLAEAHGTSAGPH--LAAEPVDEATTEPSGRSAPA 2017
Cdd:PRK07764  739 --VPLPPEPDDPPDPAGAPaqPPPPPAPAPAAAPAAAPPPS 777
SP2_N cd22540
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins ...
 1471-1883 8.24e-11

N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP2 contains the least conserved DNA-binding domain within the SP subfamily of proteins, and its DNA sequence specificity differs from the other SP proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate, or in some cases, repress expression from different promoters. The transcription factor SP2 serves as a paradigm for indirect genomic binding. It does not require its DNA-binding domain for genomic DNA binding and occupies target promoters independently of whether they contain a cognate DNA-binding motif. SP2 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP2.


Pssm-ID: 411776 [Multi-domain]  Cd Length: 511  Bit Score: 67.26  E-value: 8.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1471 PSQGLpTPSDEEPQLSQESPrtpthrPALTPAAplTTALNPPvtATEEPVVSPGPTQTTLQQPLELTASQLPAGPTESP- 1549
Cdd:cd22540     8 PSEYL-QPAASTTQDSQPSP------LALLAAT--CSKIGPP--AVEAAVTPPAPPQPTPRKLVPIKPAPLPLGPGKNSi 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1550 ---ASKGVT----ASLLAIPHTPesSSLPVALQTPTpgMVSGAMET-TRVTVIFAGSPNITVSSRSP------------P 1609
Cdd:cd22540    77 gflSAKGNIiqlqGSQLSSSAPG--GQQVFAIQNPT--MIIKGSQTrSSTNQQYQISPQIQAAGQINnsgqiqiipgtnQ 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1610 APRFPLMTKAVTVRGHGSLPVRttpPQPSLTASPSSRPVASPGAISRSPtsSGSHKAVLTP-------AVTKVISRTGVP 1682
Cdd:cd22540   153 AIITPVQVLQQPQQAHKPVPIK---PAPLQTSNTNSASLQVPGNVIKLQ--SGGNVALTLPvnnlvgtQDGATQLQLAAA 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1683 QPTQAQSAS-SPSTPLTVAGTAAEQVPVSPLATRSLEIvlstekGEAGHS----QPMGSPASPQPHPLPSAPPRPAQHTt 1757
Cdd:cd22540   228 PSKPSKKIRkKSAQAAQPAVTVAEQVETVLIETTADNI------IQAGNNllivQSPGTGQPAVLQQVQVLQPKQEQQV- 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1758 maTRSPALPPETPAAASLstatdGLAATPfmslesTRPSQllsglppdtslplakvGTSAPVATPGPKASVITTPL-QPQ 1836
Cdd:cd22540   301 --VQIPQQALRVVQAASA-----TLPTVP------QKPLQ----------------NIQIQNSEPTPTQVYIKTPSgEVQ 351

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 636526419 1837 ATTLPAQTLSPVLPFTPAAMTQAHPPTHIAPPAAGTAPGLLLGATLP 1883
Cdd:cd22540   352 TVLLQEAPAATATPSSSTSTVQQQVTANNGTGTSKPNYNVRKERTLP 398
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 701-755 2.40e-10

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 58.55  E-value: 2.40e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 636526419   701 CSVLT-GEMFAPCSAFLSPVPYFEQCRRDACRCG--QPCLCATLAHYAHLCRRHGLPV 755
Cdd:pfam08742    2 CGLLSdSGPFAPCHSVVDPEPYFEACVYDMCSCGgdDECLCAALAAYARACQAAGVCI 59
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1459-1889 4.70e-10

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 65.96  E-value: 4.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1459 VPTEALGNETLPPSQGLPTPSDE-EPQLSQESPRTPTHRPALTPAAPL----TTALNPPVTATEEPVVSPG----PTQTT 1529
Cdd:PHA03307   54 TVVAGAAACDRFEPPTGPPPGPGtEAPANESRSTPTWSLSTLAPASPAregsPTPPGPSSPDPPPPTPPPAspppSPAPD 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1530 LQQPLELTASQLPAGPTESPAskgvtasllaiphtPESSSLPVALQTPTPGMVSGAMETTRVTVIFAGSPNITVSSRSPP 1609
Cdd:PHA03307  134 LSEMLRPVGSPGPPPAASPPA--------------AGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPP 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1610 APRFPlmtkavtvrghgslpvrTTPPQPSLTASPSSRPVASPG---AISRSPTSSGSHKAVLTPAVTKVISRTGVPQPtq 1686
Cdd:PHA03307  200 AAASP-----------------RPPRRSSPISASASSPAPAPGrsaADDAGASSSDSSSSESSGCGWGPENECPLPRP-- 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1687 aqsasSPSTPLTVAGTAAEQVPVSPLatrsleivlstekgeAGHSQPMGSPASPQPHPLPSAP---PRPAQHTTMATRSP 1763
Cdd:PHA03307  261 -----APITLPTRIWEASGWNGPSSR---------------PGPASSSSSPRERSPSPSPSSPgsgPAPSSPRASSSSSS 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1764 ALPPETPAAASLSTATDGLAATPfmSLESTRPSQLLSGLPPDTSLPLAKVGTSAPVATPGPKASVITTPLQPQATTLPAQ 1843
Cdd:PHA03307  321 SRESSSSSTSSSSESSRGAAVSP--GPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRA 398

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 636526419 1844 TLSPVLPFTPAAMTQAHPPTHIAPPAAGTAPGLLL---GATLPTSGVLP 1889
Cdd:PHA03307  399 RRRDATGRFPAGRPRPSPLDAGAASGAFYARYPLLtpsGEPWPGSPPPP 447
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
1603-1868 7.55e-10

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 64.87  E-value: 7.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1603 VSSRSPPAPRFPLMTKAVTVRGHGSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAV--TKVISRTG 1680
Cdd:PRK07003  375 RVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADgdAPVPAKAN 454

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1681 VPQPTQAQSASSPSTPLTVAGTAAEQVPVSPLATRSleivlsTEKGEAGHSQPMGSPASPQPHPlPSAPPRPAQHTTMAT 1760
Cdd:PRK07003  455 ARASADSRCDERDAQPPADSGSASAPASDAPPDAAF------EPAPRAAAPSAATPAAVPDARA-PAAASREDAPAAAAP 527

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1761 RSPALPPETPAAASLSTATDGLAA------TPFMSLESTRpsqllSGLPPDTSLPLAKVGTSAPVATPGPKASViTTPLQ 1834
Cdd:PRK07003  528 PAPEARPPTPAAAAPAARAGGAAAaldvlrNAGMRVSSDR-----GARAAAAAKPAAAPAAAPKPAAPRVAVQV-PTPRA 601

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 636526419 1835 PQATtlPAQTLSPVLPFTPAAMT-QAHPPTHIAPP 1868
Cdd:PRK07003  602 RAAT--GDAPPNGAARAEQAAESrGAPPPWEDIPP 634
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1680-2044 2.51e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 63.42  E-value: 2.51e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1680 GVPQPTQAQSASSPSTPLTVAGTAAEQVPVSPLA-TRSLEIVLSTEKGEaghsqpmgspasPQPhPLPSAPPRPAQHTTM 1758
Cdd:PHA03247 2502 GPPDPDAPPAPSRLAPAILPDEPVGEPVHPRMLTwIRGLEELASDDAGD------------PPP-PLPPAAPPAAPDRSV 2568

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1759 ATRSPALPPETPAAASlstatdglaatpfmslESTRPsqllsGLPPDTSLPLAKVGTSAPVATPGPKASV--ITTPLQPQ 1836
Cdd:PHA03247 2569 PPPRPAPRPSEPAVTS----------------RARRP-----DAPPQSARPRAPVDDRGDPRGPAPPSPLppDTHAPDPP 2627

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1837 ATTLPAQTLSPVLPFTPAAMTQAHP-----PTHIAPPAAGTAPGLLLGATLPTSG----VLPVAEGTASMVSVVPRKSTT 1907
Cdd:PHA03247 2628 PPSPSPAANEPDPHPPPTVPPPERPrddpaPGRVSRPRRARRLGRAAQASSPPQRprrrAARPTVGSLTSLADPPPPPPT 2707

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1908 GKVAILSKQVSLPTSMYGSAEGGPTELTPATshPLTPLVAEPEGAQAGTAlPVPTSYALSRVSARTAPQDSMLVLLPQLA 1987
Cdd:PHA03247 2708 PEPAPHALVSATPLPPGPAAARQASPALPAA--PAPPAVPAGPATPGGPA-RPARPPTTAGPPAPAPPAAPAAGPPRRLT 2784

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 636526419 1988 EAHGTSAGPHLAAEPvdeATTEPSGRSAPALSIVEGLAEALATTTEANTSTTCVPIA 2044
Cdd:PHA03247 2785 RPAVASLSESRESLP---SPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTA 2838
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 1470-1837 3.50e-09

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 62.70  E-value: 3.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1470 PPSQGLPTPSDEEPQLSQESPRTPTHRPALTPAAPLTTALNPPVTATEEPVVSPGPTQTTLQQPLELTASQLPAGPTESP 1549
Cdd:PRK07764  431 PAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAA 510

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1550 ASKGVTASLLAIPHTPESSSLPVALQTPTPGMVSGametTRVTVIFagspnitvsSRSPPAPRF------PLMTKAVTVR 1623
Cdd:PRK07764  511 TLRERWPEILAAVPKRSRKTWAILLPEATVLGVRG----DTLVLGF---------STGGLARRFaspgnaEVLVTALAEE 577

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1624 GHGSLpvrttppQPSLTASPSsrPVASPGAISRSPTSSGSHKAVLTPAVTKVISRTGVPQPTQAQSASSPSTPLTVAGTA 1703
Cdd:PRK07764  578 LGGDW-------QVEAVVGPA--PGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVA 648

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1704 AEQVPVSPLATRSLEIVLSTEKGEAGHSQPMGSPASPQP--HPLPSAPPRPAQHTTMATRSPALPPETPAAASLSTATDG 1781
Cdd:PRK07764  649 APEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPaaPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGA 728

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 636526419 1782 LAATPFMSLESTRPSQ-LLSGLPPDTSLPLAKVGTSAPVATPGPKASVITTPLQPQA 1837
Cdd:PRK07764  729 SAPSPAADDPVPLPPEpDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEM 785
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1460-1797 4.98e-09

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 62.40  E-value: 4.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1460 PTEALGNETLPPSQ-GLPTPSDEEPQLSQESPRTPTHRpaltpaaplttalNPPVTATEEPVVSPGPTQTtlQQPLEL-T 1537
Cdd:PTZ00449  510 PPEGPEASGLPPKApGDKEGEEGEHEDSKESDEPKEGG-------------KPGETKEGEVGKKPGPAKE--HKPSKIpT 574

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1538 ASQLPAGPTESPASKGvtasllaiPHTPESSSLPVALQTPTpgmvsgamettrvtvifagspnitvSSRSPPAPRFPLMT 1617
Cdd:PTZ00449  575 LSKKPEFPKDPKHPKD--------PEEPKKPKRPRSAQRPT-------------------------RPKSPKLPELLDIP 621

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1618 KAVTVRGHGSLPVRttPPQPSLTASPsSRPvASPGAIsRSPTSSGSHKAVLTPAVTKVI-------------SRTGVPQP 1684
Cdd:PTZ00449  622 KSPKRPESPKSPKR--PPPPQRPSSP-ERP-EGPKII-KSPKPPKSPKPPFDPKFKEKFyddyldaaakskeTKTTVVLD 696

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1685 TQAQSASSPSTPLTVAGTAAEQVPVSPLATRSleivlstekgEAGHSQPMGSPASPQPHPLPSAPPRPAQHTTMAtrspa 1764
Cdd:PTZ00449  697 ESFESILKETLPETPGTPFTTPRPLPPKLPRD----------EEFPFEPIGDPDAEQPDDIEFFTPPEEERTFFH----- 761

                         330       340       350
                  ....*....|....*....|....*....|...
gi 636526419 1765 lppETPAAASLSTATDGLAATPFMSLESTRPSQ 1797
Cdd:PTZ00449  762 ---ETPADTPLPDILAEEFKEEDIHAETGEPDE 791
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 768-832 9.57e-09

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 53.47  E-value: 9.57e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 636526419  768 CEASKEYSPCVAPCGRTCQDLASPEACgvdggddlsRDECVEGCACPPDTYLDTQaDLCVPRNQC 832
Cdd:cd19941     1 CPPNEVYSECGSACPPTCANPNAPPPC---------TKQCVEGCFCPEGYVRNSG-GKCVPPSQC 55
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 768-832 1.09e-08

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 53.55  E-value: 1.09e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 636526419   768 CEASKEYSPCVAPCGRTCQDLASPEACgvdggddlsRDECVEGCACPPDTYLDTQaDLCVPRNQC 832
Cdd:pfam01826    1 CPANEVYSECGSACPPTCANLSPPDVC---------PEPCVEGCVCPPGFVRNSG-GKCVPPSDC 55
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 1621-2000 1.44e-08

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 60.94  E-value: 1.44e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1621 TVRGHGSLPV-----RTTPPQPSLTASPSSRPVASPGAISRS--PTSSGSHKAVLTPAVTKVIsRTGVPQP--------- 1684
Cdd:pfam03154    7 TRRSRGSMSTlrsgrKKQTASPDGRASPTNEDLRSSGRNSPSaaSTSSNDSKAESMKKSSKKI-KEEAPSPlksakrqre 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1685 ----------------TQAQSASSPSTPLTVAGTAAEqvpvsplaTRSLEIVLSTEKGEAGHSQPMGSPASPQPHPLPSA 1748
Cdd:pfam03154   86 kgasdteeperatakkSKTQEISRPNSPSEGEGESSD--------GRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESD 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1749 PPRPAQHTTMATRSPALPPETPAAASLSTATDGLAATPFMSLESTRPSQLLSGLPPDTSLPLAKVGTSAPVatpgpkasv 1828
Cdd:pfam03154  158 SDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPH--------- 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1829 itTPLQPQATTLPAQTLSPVLPFTPaaMTQAHPPTHIAPPAagTAPGLLLGATLPtsGVLPVAEGTASMVSVVPRKSTTG 1908
Cdd:pfam03154  229 --TLIQQTPTLHPQRLPSPHPPLQP--MTQPPPPSQVSPQP--LPQPSLHGQMPP--MPHSLQTGPSHMQHPVPPQPFPL 300

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1909 KVAILSKQVSLPTSMYGSAEGGPTELTPATShpltplvAEPEGAQAGTALPVPTSyALSRVSARTAPQDSmlvlLPQLAE 1988
Cdd:pfam03154  301 TPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQ-------SQLQSQQPPREQPLPPA-PLSMPHIKPPPTTP----IPQLPN 368

                          410
                   ....*....|..
gi 636526419  1989 AHGTSAGPHLAA 2000
Cdd:pfam03154  369 PQSHKHPPHLSG 380
C8 smart00832
This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have ...
 699-755 1.66e-08

This domain contains 8 conserved cysteine residues; Not all of the conserved cysteines have been included in the alignment model. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.


Pssm-ID: 214843  Cd Length: 76  Bit Score: 53.50  E-value: 1.66e-08
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 636526419    699 QACSVLTGEM--FAPCSAFLSPVPYFEQCRRDACRCG--QPCLCATLAHYAHLCRRHGLPV 755
Cdd:smart00832    6 SQCGILLSPRgpFAACHSVVDPEPFFENCVYDTCACGgdCECLCDALAAYAAACAEAGVCI 66
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
1454-1913 2.18e-08

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 60.25  E-value: 2.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1454 EPAVWVPTEALGNETLPPSQGLPTPSDEEPQLSQESPRTPTHRPALTPAAPLTTALNPPVTATEE--PVVSPGPTQTtlq 1531
Cdd:PRK07003  359 EPAVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAeaPPAAPAPPAT--- 435

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1532 qpleltasqlpAGPTESPASKGVTA-SLLAIPHTPESSSLPVALQTPTpgmvsgamettrvtvifAGSPNITVSSRSPPA 1610
Cdd:PRK07003  436 -----------ADRGDDAADGDAPVpAKANARASADSRCDERDAQPPA-----------------DSGSASAPASDAPPD 487

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1611 PRFPLMTKAVTVRGHGSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTssgshkavltpavtkvisrtgvpqPTQAQSA 1690
Cdd:PRK07003  488 AAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEARPPT------------------------PAAAAPA 543

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1691 SSpstpltvAGTAAEQVPVsplaTRSLEIVLSTEKGEAGHSQPmgSPASPQPHPLPSAPPRpaqhttmatrsPALPPETP 1770
Cdd:PRK07003  544 AR-------AGGAAAALDV----LRNAGMRVSSDRGARAAAAA--KPAAAPAAAPKPAAPR-----------VAVQVPTP 599

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1771 -AAASLSTATDGLAATPFMSLESTRPSQLLSGLPPDTSLPLAK---VGTS----APVATPGPKaSVITTPLQPQATTLPA 1842
Cdd:PRK07003  600 rARAATGDAPPNGAARAEQAAESRGAPPPWEDIPPDDYVPLSAdegFGGPddgfVPVFDSGPD-DVRVAPKPADAPAPPV 678

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1843 QT--LSPVLPFTPAAMTQAHPPthiappaagtapgllLGATLPTSGV---------LPVAEGTASMVSV-VPRKSTTGKV 1910
Cdd:PRK07003  679 DTrpLPPAIPLDAIGFDGEWPA---------------LAARLPLKGVayqlafnseLTAADGGTLKLAVpVPQYADAAQV 743


                  ...
gi 636526419 1911 AIL 1913
Cdd:PRK07003  744 AKL 746
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 1631-1921 2.68e-08

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 60.10  E-value: 2.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1631 RTTPPQ-----PSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAVTKVISRTGVPQPTQA-QSASSPSTPLTVAGTAA 1704
Cdd:PRK10263  298 RATQPEydeydPLLNGAPITEPVAVAAAATTATQSWAAPVEPVTQTPPVASVDVPPAQPTVAwQPVPGPQTGEPVIAPAP 377

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1705 EQVPVSPlatrsleivlSTEKGEAGHSQPMGSPASPQPHPLPSAPPRPAQ--------HTTMATRSPALPPETPAAASLS 1776
Cdd:PRK10263  378 EGYPQQS----------QYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQqpyyapapEQPAQQPYYAPAPEQPVAGNAW 447

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1777 TATDglAATPFMSLESTRPSQ-LLSGLPPDTSLPLAKVGTSAPVATPGPKASViTTPLQP-------------------- 1835
Cdd:PRK10263  448 QAEE--QQSTFAPQSTYQTEQtYQQPAAQEPLYQQPQPVEQQPVVEPEPVVEE-TKPARPplyyfeeveekrarereqla 524

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1836 ---QATTLPAQTLSPVLPFTPAAMTQAHPPTHIAPPAAGTAPGlLLGATLPTSGVLPVAEGTASMVS-VVPR---KSTTG 1908
Cdd:PRK10263  525 awyQPIPEPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPLASG-VKKATLATGAAATVAAPVFSLANsGGPRpqvKEGIG 603

                         330
                  ....*....|...
gi 636526419 1909 KVAILSKQVSLPT 1921
Cdd:PRK10263  604 PQLPRPKRIRVPT 616
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 1629-1867 6.36e-08

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 58.40  E-value: 6.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1629 PVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAVTKVisrtgvPQPTQAQSASSPSTPLTVAGTAAEQVP 1708
Cdd:PLN03209  341 PVPTKPVTPEAPSPPIEEEPPQPKAVVPRPLSPYTAYEDLKPPTSPI------PTPPSSSPASSKSVDAVAKPAEPDVVP 414

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1709 VSPLATRSLEIVLSTEkgEAGHSQPMgSPAS------PQPHPLPSAPPRPAQHTTMATRSPALPPETPAAASLSTATDgl 1782
Cdd:PLN03209  415 SPGSASNVPEVEPAQV--EAKKTRPL-SPYAryedlkPPTSPSPTAPTGVSPSVSSTSSVPAVPDTAPATAATDAAAP-- 489

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1783 aATPFMSLEStrPSQLLSGLPPDTS-LPLAKVGTSAPVATPGP----KASVITTPLQPQATTLPAQtlSPVLPFTpaAMT 1857
Cdd:PLN03209  490 -PPANMRPLS--PYAVYDDLKPPTSpSPAAPVGKVAPSSTNEVvkvgNSAPPTALADEQHHAQPKP--RPLSPYT--MYE 562

                         250
                  ....*....|
gi 636526419 1858 QAHPPTHIAP 1867
Cdd:PLN03209  563 DLKPPTSPTP 572
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1736-2042 7.00e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.80  E-value: 7.00e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1736 SPASPQPHPLPSAPPRPAQHTtmatrspalPPETPAAASLSTATDGLAATPFM--------SLESTRPSQLLSGLPPDts 1807
Cdd:PHA03247 2490 FAAGAAPDPGGGGPPDPDAPP---------APSRLAPAILPDEPVGEPVHPRMltwirgleELASDDAGDPPPPLPPA-- 2558

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1808 LPLAKVGTSAPVATPGPKasvittPLQPQATT------LPAQTLSPVLPFTPAAMTQAHPPTHIAPPAAgTAPGLLLGAT 1881
Cdd:PHA03247 2559 APPAAPDRSVPPPRPAPR------PSEPAVTSrarrpdAPPQSARPRAPVDDRGDPRGPAPPSPLPPDT-HAPDPPPPSP 2631

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1882 LPTSGVLPVAEGTASMVSVVPRKSTTGKVAILSKQV---SLPTSMYGSAEGGPTELTPATSHPLT--------PLVAEPE 1950
Cdd:PHA03247 2632 SPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRArrlGRAAQASSPPQRPRRRAARPTVGSLTsladppppPPTPEPA 2711

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1951 GAQAGTALPVPTSYALSRVSARTAPQDSMLVLLPQLAEAHG---------TSAGPHLAAEPVDEATTEPSGRSAPALSIV 2021
Cdd:PHA03247 2712 PHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGgparparppTTAGPPAPAPPAAPAAGPPRRLTRPAVASL 2791

                         330       340
                  ....*....|....*....|.
gi 636526419 2022 EGLAEALATTTEANTSTTCVP 2042
Cdd:PHA03247 2792 SESRESLPSPWDPADPPAAVL 2812
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
1714-1976 7.01e-08

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 58.32  E-value: 7.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1714 TRSLEIVLSTEKGEAGHSQPMGSPASPQPHPLPSAPPRPAQHTTMATRSPALPPETPAAASLSTATDGLAATPFMSLEST 1793
Cdd:PRK07003  349 TMTLLRMLAFEPAVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPA 428

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1794 RPSQLLSG----LPPDTSLPLAKVGTSAPVATPGPKASVITTPLQPQATTLPAQTLSPVLPFTPA------AMTQAHPPT 1863
Cdd:PRK07003  429 APAPPATAdrgdDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPApraaapSAATPAAVP 508

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1864 HIAPPAAGTAPGLLLGATLPTSGVLPVAEGTASmvsvvPRKSTTGKVAILSkqVSLPTSMYGSAEGGptELTPATSHPLT 1943
Cdd:PRK07003  509 DARAPAAASREDAPAAAAPPAPEARPPTPAAAA-----PAARAGGAAAALD--VLRNAGMRVSSDRG--ARAAAAAKPAA 579

                         250       260       270
                  ....*....|....*....|....*....|...
gi 636526419 1944 PLVAEPEGAQAGTALPVPTSYALSRVSARTAPQ 1976
Cdd:PRK07003  580 APAAAPKPAAPRVAVQVPTPRARAATGDAPPNG 612
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 1427-2019 7.52e-08

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 58.15  E-value: 7.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1427 EGCVPVCPTPQVLDEVTQRCVYLEDCVE---PAVWVPTEALGNETLPPSQGLPTPSDEEPQLSQesprTPTHRP---ALT 1500
Cdd:COG5180    24 PVLSPELWAAANNDAVSQGDRSALASSPtrpYARKIFEPLDIKLALGKPQLPSVAEPEAYLDPA----PPKSSPdtpEEQ 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1501 PAAPLTTALNPPVTATEEpvvSPGPTQTTLQQPLELTASQLPAGPTESPASKGVTASLLAIPHTPESSSLPVALQTPTPG 1580
Cdd:COG5180   100 LGAPAGDLLVLPAAKTPE---LAAGALPAPAAAAALPKAKVTREATSASAGVALAAALLQRSDPILAKDPDGDSASTLPP 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1581 MVSGAMETTRVtvifagsPNITVSSRSPPAPRFPLMTKAvtvrghgslPVRTTPPQPSLTASPSSRPVASPGAISRSPTS 1660
Cdd:COG5180   177 PAEKLDKVLTE-------PRDALKDSPEKLDRPKVEVKD---------EAQEEPPDLTGGADHPRPEAASSPKVDPPSTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1661 SGSHKAVLTPAVTKVISRTGVPQPTQAQSASSPSTP---LTVAGTAAEQVPVSPLAtrslEIVLSTEKGEAGHSQPMGSP 1737
Cdd:COG5180   241 EARSRPATVDAQPEMRPPADAKERRRAAIGDTPAAEppgLPVLEAGSEPQSDAPEA----ETARPIDVKGVASAPPATRP 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1738 ASPQPHPLPSAPPRPAQhttmATRSPALPPEtpaaaslstatdglAATPfmslESTRPsqllSGLPPdtslplakvGTSA 1817
Cdd:COG5180   317 VRPPGGARDPGTPRPGQ----PTERPAGVPE--------------AASD----AGQPP----SAYPP---------AEEA 361

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1818 PVATPGPkasvittPLQPQattlPAQTLSPVLPFTPAAMTQAHPPTHIAPPAAGTAPGLLLGATLPTSGVLPVAEGTASM 1897
Cdd:COG5180   362 VPGKPLE-------QGAPR----PGSSGGDGAPFQPPNGAPQPGLGRRGAPGPPMGAGDLVQAALDGGGRETASLGGAAG 430

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1898 VSVVPRKSTTGKVAIlskqvslptsmygSAEGGPTELTPATSHPLTPLVAEPEgAQAGTALPVPTsyalsrvsartaPQD 1977
Cdd:COG5180   431 GAGQGPKADFVPGDA-------------ESVSGPAGLADQAGAAASTAMADFV-APVTDATPVDV------------ADV 484

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|...
gi 636526419 1978 SMLVLLPQLAEAHGTSAG-PHLAAEPVDEATTEPSGRSAPALS 2019
Cdd:COG5180   485 LGVRPDAILGGNVAPASGlDAETRIIEAEGAPATEDFVAAELS 527
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 1690-2018 2.31e-07

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 56.51  E-value: 2.31e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1690 ASSPSTPLTVA-GTAAEQVPVSPLAT----RSLEIVLSTEKGEAGHSQPMGSPASPQphplpSAPPRPAQHTTMATRS-- 1762
Cdd:pfam17823   63 ATAAPAPVTLTkGTSAAHLNSTEVTAehtpHGTDLSEPATREGAADGAASRALAAAA-----SSSPSSAAQSLPAAIAal 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1763 PALPPETPAAASLSTATDGLAATPFMSLESTRpsqllsglppdtslplakVGTSAPVATPGPKASVITTPLQPQATTLPA 1842
Cdd:pfam17823  138 PSEAFSAPRAAACRANASAAPRAAIAAASAPH------------------AASPAPRTAASSTTAASSTTAASSAPTTAA 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1843 QTlspvlpfTPAAMTQAHP----PTHIAPPAAGTAPGlLLGATLPTSGVLPVAEGTASMVSVVPRKSTTGKVAilSKQVS 1918
Cdd:pfam17823  200 SS-------APATLTPARGistaATATGHPAAGTALA-AVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVA--SAAGT 269

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1919 LPTSMYGSAEGGPTELTPATSHPLTPlvAEPEGAQA-GTALPVPTSYALSRVSARTAPQDSMLVLLPQLAEAHGTSAGPH 1997
Cdd:pfam17823  270 INMGDPHARRLSPAKHMPSDTMARNP--AAPMGAQAqGPIIQVSTDQPVHNTAGEPTPSPSNTTLEPNTPKSVASTNLAV 347

                          330       340
                   ....*....|....*....|.
gi 636526419  1998 LAAEPVDeaTTEPSGRSAPAL 2018
Cdd:pfam17823  348 VTTTKAQ--AKEPSASPVPVL 366
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 1475-1875 3.36e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 56.15  E-value: 3.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1475 LPTPSDEEPQLSQESPRTPTHRPALTPAAPLTTALNPPVTATEEPVVSPGPTQTTLQQPLELTASQLPAGPTESPASKGV 1554
Cdd:PRK07764  364 LPSASDDERGLLARLERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPS 443

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1555 TASllaiphTPESSSLPVALQTPTPGMVSGAMETTRVTVIFAGSPNITVSSRSPPAPRFPlmtkAVTVRGHGSLPVRTTP 1634
Cdd:PRK07764  444 PAG------NAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAP----AAPAAPAGADDAATLR 513

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1635 PQ-PSLTASPSSRPVASPGAISRSPTSSGSHKAVLTpavtkvisrTGVPQPTQAQSASSPSTPLTVAGTAAEQV------ 1707
Cdd:PRK07764  514 ERwPEILAAVPKRSRKTWAILLPEATVLGVRGDTLV---------LGFSTGGLARRFASPGNAEVLVTALAEELggdwqv 584

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1708 -------PVSPLATRSLEIVLSTEKGEAGHSQPMGSPASPQPHPLPSAPPRPAQHTTMATRSPALPPETPAAASLSTATD 1780
Cdd:PRK07764  585 eavvgpaPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASD 664

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1781 GLAATPfmsLESTRPSQLLSGLPPDTSLPLAKVGTSAPVATPGPKASVITTPLQPQATTLPAQTLSPVLPFTPAAMTQAH 1860
Cdd:PRK07764  665 GGDGWP---AKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPL 741

                         410
                  ....*....|....*
gi 636526419 1861 PPTHIAPPAAGTAPG 1875
Cdd:PRK07764  742 PPEPDDPPDPAGAPA 756
beta-trefoil_ABD_ABFB cd23399
Arabinose-binding domain (ABD), beta-trefoil fold, found in alpha-L-arabinofuranosidase B (ABF ...
 1293-1382 4.71e-07

Arabinose-binding domain (ABD), beta-trefoil fold, found in alpha-L-arabinofuranosidase B (ABF B) and similar proteins; Alpha-L-arabinofuranosidase (EC 3.2.1.55), also called ABF, or non-reducing end alpha-L-arabinofuranosidase, or arabinofuranosidase, or arabinosidase, is involved in the degradation of arabinoxylan, a major component of plant hemicellulose. It can hydrolyze 1,5-, 1,3- and 1,2-alpha-linkages not only in L-arabinofuranosyl oligosaccharides, but also in polysaccharides containing terminal non-reducing L-arabinofuranoses in side chains, like L-arabinan, arabinogalactan and arabinoxylan. ABF belongs to the glycosyl hydrolase 54 family. The family also includes Hungateiclostridium thermocellum anti-sigma-I factor RsgI5. It negatively regulates SigI5 activity through direct interaction. Binding of the polysaccharide substrate to the extracellular C-terminal sensing domain of RsgI5 may induce a conformational change in its N-terminal cytoplasmic region, leading to the release and activation of SigI5. Members of the ABFB family contain an ABD with a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ABD binds two arabinose molecules in the beta and gamma subdomains.


Pssm-ID: 467809  Cd Length: 138  Bit Score: 51.44  E-value: 4.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1293 DPDVVSLEAADRPNFFL-HvtANGSLELAKWQGRDTFQQHASFLLHRGTRQAGLVALESLAKPSSFLYVSGAVLALRLYE 1371
Cdd:cd23399    50 DSGCVSFESVNYPGYYLrH--YNFRLRLDKNDGSALFKEDATFCPRPGLADGGGVSFRSYNYPGRYIRHRNFELWLDPND 127

                          90
                  ....*....|.
gi 636526419 1372 HTEVFRRGTLF 1382
Cdd:cd23399   128 GTALFRQDATF 138
Treacle pfam03546
Treacher Collins syndrome protein Treacle;
1478-1900 5.09e-07

Treacher Collins syndrome protein Treacle;


Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 55.08  E-value: 5.09e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1478 PSDEEPQL------SQESPR--TPTHRPALT-PAAPLTTALNP---PVTATEE-------PVVSPGPTQTTLQQPL---- 1534
Cdd:pfam03546   49 PSGKTPQVraasapAKESPRkgAPPVPPGKTgPAAAQAQAGKPeedSESSSEEsdsdgetPAAATLTTSPAQVKPLgkns 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1535 ----ELTASQLPAGPTESPASKGVTASLLAIPHTP------ESSSLPVALQTPTPGMVSGAMETTRVTVIFAGSPNITVS 1604
Cdd:pfam03546  129 qvrpASTVGKGPSGKGANPAPPGKAGSAAPLVQVGkkeedsESSSEESDSEGEAPPAATQAKPSGKILQVRPASGPAKGA 208

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1605 SRSPPAPRFPLMTKAVTVRGHGSLPVRTTPPQPSLTASPSSRPV-ASPGAISRSPTSSGSHKAVLTPAVTKVIS-RTGVP 1682
Cdd:pfam03546  209 APAPPQKAGPVATQVKAERSKEDSESSEESSDSEEEAPAAATPAqAKPALKTPQTKASPRKGTPITPTSAKVPPvRVGTP 288

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1683 QPTQAQSASSPstpltvagtAAEQVPVSPLATRSLEIVLSTEKGEAGHSQPMGSPASPQPHPLPSAPPrpaqhtTMATRS 1762
Cdd:pfam03546  289 APWKAGTVTSP---------ACASSPAVARGAQRPEEDSSSSEESESEEETAPAAAVGQAKSVGKGLQ------GKAASA 353

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1763 PALPPETPAAASLSTATDGLAATPF--MSLESTRPSQLLSGlppdtslplakvgTSAPVATPGPKASVITTPlQPQATTL 1840
Cdd:pfam03546  354 PTKGPSGQGTAPVPPGKTGPAVAQVkaEAQEDSESSEEESD-------------SEEAAATPAQVKASGKTP-QAKANPA 419

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 636526419  1841 PAQT-LSPVLPFTPAAMTQAHPPTHIAPPAAGTAPglllGATLPTSGVLpvAEGTASMVSV 1900
Cdd:pfam03546  420 PTKAsSAKGAASAPGKVVAAAAQAKQGSPAKVKPP----ARTPQNSAIS--VRGQASVPAV 474
PHA03378 PHA03378
EBNA-3B; Provisional
 1446-1829 5.77e-07

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 55.46  E-value: 5.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1446 CVYLEDCV----EPAVWVPT--EALGNETLPPSQGLPTPSDEEPQLSQESPR-----TPTHRPALTPAAPLTTALNPPVT 1514
Cdd:PHA03378  540 CVYTEDLDiesdEPASTEPVhdQLLPAPGLGPLQIQPLTSPTTSQLASSAPSyaqtpWPVPHPSQTPEPPTTQSHIPETS 619

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1515 A---------------------TEEPVVSPGPTQT-----TLQQPLELTASQLPAGPTESPASkgvtaSLLAIPHTPESS 1568
Cdd:PHA03378  620 AprqwpmplrpipmrplrmqpiTFNVLVFPTPHQPpqveiTPYKPTWTQIGHIPYQPSPTGAN-----TMLPIQWAPGTM 694

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1569 SLPVALQTPT--PGMVSGAMETTRVTVIFAGSPNITVSSRSPPAPRFPLMtkavtvRGHGSLPVRTTPPQPSLTASPSsr 1646
Cdd:PHA03378  695 QPPPRAPTPMrpPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRA------RPPAAAPGRARPPAAAPGRARP-- 766

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1647 PVASPGAISRSPTSSGSHKAVLTPavtkvisrTGVPQPTQAQSASSPSTPLTVAGTAAEQVPVSPLATRSLEIVL----- 1721
Cdd:PHA03378  767 PAAAPGAPTPQPPPQAPPAPQQRP--------RGAPTPQPPPQAGPTSMQLMPRAAPGQQGPTKQILRQLLTGGVkrgrp 838

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1722 STEKGEAGHSQpmgSPASPQPHPLPSAPPRPAQHTTMAtrSPALPP-ETPAAASLSTATdGLAATPFMSLESTRPSQLLS 1800
Cdd:PHA03378  839 SLKKPAALERQ---AAAGPTPSPGSGTSDKIVQAPVFY--PPVLQPiQVMRQLGSVRAA-AASTVTQAPTEYTGERRGVG 912

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 636526419 1801 GLPPDTSLPLAKVGTSA------PVATPGPKASVI 1829
Cdd:PHA03378  913 PMHPTDIPPSKRAKTDAyvesqpPHGGQSHSFSVI 947
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1455-1809 7.80e-07

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 54.92  E-value: 7.80e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1455 PAVWVPTEALGNETL---PPSQGL--PTPSDEEPQLSQESPRTPTHRPALTPAAPLTTALNPPVTATEEPVVSPGPTQTT 1529
Cdd:pfam05109  525 PAVTTPTPNATSPTLgktSPTSAVttPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNATSPTVGETSPQANT 604

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1530 LQQPLELTASQlpagPTESPASKGVTASLLAIPHTPESSSlpVALQTPTPGMVSGAMettrvtvifagSPNITVSSRSpp 1609
Cdd:pfam05109  605 TNHTLGGTSST----PVVTSPPKNATSAVTTGQHNITSSS--TSSMSLRPSSISETL-----------SPSTSDNSTS-- 665

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1610 apRFPLMTKAVTVRGHGSLPVrtTPPQPSLTASPSSRPVASPGAISRSpTSSGSHKAVLTPAvtkvisRTGVPQPTQAQS 1689
Cdd:pfam05109  666 --HMPLLTSAHPTGGENITQV--TPASTSTHHVSTSSPAPRPGTTSQA-SGPGNSSTSTKPG------EVNVTKGTPPKN 734

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1690 ASSPSTPltvagtaAEQVPVSPLATRSLEIVLSTEKGEagHSQPMGSPASPQPhplpsAPPRPAQHTTMATRSPALPPET 1769
Cdd:pfam05109  735 ATSPQAP-------SGQKTAVPTVTSTGGKANSTTGGK--HTTGHGARTSTEP-----TTDYGGDSTTPRTRYNATTYLP 800

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 636526419  1770 PAAASLSTATDGLAATPFMSLESTRPsqllsgLPPdTSLP 1809
Cdd:pfam05109  801 PSTSSKLRPRWTFTSPPVTTAQATVP------VPP-TSQP 833
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1642-1876 8.34e-07

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 55.08  E-value: 8.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1642 SPSSRPVASPGA-----ISRSPTSSGSHKAVLTPAVTKVISRTGVPQ-PTQAQSASSPSTPLTVAGTAAeqvPVSPLATR 1715
Cdd:PTZ00449  540 SDEPKEGGKPGEtkegeVGKKPGPAKEHKPSKIPTLSKKPEFPKDPKhPKDPEEPKKPKRPRSAQRPTR---PKSPKLPE 616

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1716 SLEIVLSTEKGEAGHSqpmgsPASPQPHPLPSAPPRPAQHTTMATRSPALPPETP----------------AAASLSTAT 1779
Cdd:PTZ00449  617 LLDIPKSPKRPESPKS-----PKRPPPPQRPSSPERPEGPKIIKSPKPPKSPKPPfdpkfkekfyddyldaAAKSKETKT 691

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1780 DGLAATPFMS-LESTRPSQllSGLPPDTSLPLAKV---GTSAPVATPGPKASVITTPLQ---------------PQATTL 1840
Cdd:PTZ00449  692 TVVLDESFESiLKETLPET--PGTPFTTPRPLPPKlprDEEFPFEPIGDPDAEQPDDIEfftppeeertffhetPADTPL 769

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 636526419 1841 P-------------AQTLSPvlpftPAAMTQAHPPTHIAPPAAGTAPGL 1876
Cdd:PTZ00449  770 PdilaeefkeedihAETGEP-----DEAMKRPDSPSEHEDKPPGDHPSL 813
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1680-1886 8.93e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 54.88  E-value: 8.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1680 GVPQPTQAQSASSPSTPLTVAGTAAEQVPVSPLATRSleivLSTEKGEAGHSQPMG-SPASPQPHPLPSAPPRPAQHTTM 1758
Cdd:PRK12323  371 GAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPA----AAPAAAAAARAVAAApARRSPAPEALAAARQASARGPGG 446

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1759 ATRSPALPPETPA------AASLSTATDGLAATPFMSLESTRPSQLLSGLPPDTSLP--LAKVGTSAPVATPGPKASVIT 1830
Cdd:PRK12323  447 APAPAPAPAAAPAaaarpaAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPpeFASPAPAQPDAAPAGWVAESI 526

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 636526419 1831 TPLQPQATTLPAQTLSPVLPFTPAAMTQAHPPTHIAP-PAAGTAPGLL---------LGATLPTSG 1886
Cdd:PRK12323  527 PDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPrPPRASASGLPdmfdgdwpaLAARLPVRG 592
PHA03379 PHA03379
EBNA-3A; Provisional
 1471-1875 1.19e-06

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 54.29  E-value: 1.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1471 PSQGLPTPSDE--EPQLSQESPRTPTHRPALTPAAPlTTALNPPVTATEEPVVSPGPTQTTLQQPLELTA--SQLPaGPT 1546
Cdd:PHA03379  411 PTYGTPRPPVEkpRPEVPQSLETATSHGSAQVPEPP-PVHDLEPGPLHDQHSMAPCPVAQLPPGPLQDLEpgDQLP-GVV 488

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1547 ESPASKGVTASLLAIPHTP--ESSSLPVALQTPTPGMvsgameTTRVTVIFAGSPNITVSSRSPPAPRFPLMTKavtvrg 1624
Cdd:PHA03379  489 QDGRPACAPVPAPAGPIVRpwEASLSQVPGVAFAPVM------PQPMPVEPVPVPTVALERPVCPAPPLIAMQG------ 556

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1625 hgslpvrttPPQPSLTASPSSRPVASPGAisrsptssgshkavltpavtkvisrtgvPQPTQaqsassPSTPLTVAGTAA 1704
Cdd:PHA03379  557 ---------PGETSGIVRVRERWRPAPWT----------------------------PNPPR------SPSQMSVRDRLA 593

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1705 EQVPVSPLATRSLEiVLSTEKGEAGHSQPMGSPASPQPHPLPSAPPRPAQHTTMATRSPALPPETPAAASLSTATDGLAA 1784
Cdd:PHA03379  594 RLRAEAQPYQASVE-VQPPQLTQVSPQQPMEYPLEPEQQMFPGSPFSQVADVMRAGGVPAMQPQYFDLPLQQPISQGAPL 672

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1785 TPFMSLESTRPSqllsgLPPDT--------SLPLAKvGTSAPVATPGPKAsviTTPLQPQATTLPAQTLSPV-------- 1848
Cdd:PHA03379  673 APLRASMGPVPP-----VPATQpqyfdiplTEPINQ-GASAAHFLPQQPM---EGPLVPERWMFQGATLSQSvrpgvaqs 743

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 636526419 1849 ----LPFT-------PAAMTQAHPPT-----------HIAPPAAGTAPG 1875
Cdd:PHA03379  744 qyfdLPLTqpinhgaPAAHFLHQPPMegpwvpeqwmfQGAPPSQGTDVV 792
PRK12727 PRK12727
flagellar biosynthesis protein FlhF;
1568-1766 1.65e-06

flagellar biosynthesis protein FlhF;


Pssm-ID: 237182 [Multi-domain]  Cd Length: 559  Bit Score: 53.84  E-value: 1.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1568 SSLPVALQTPTPGMVSGAMETTRVTVIFAGSPNITVSSRSPPAPRFPLMTKAVTVRGHGSLPVRTTPPQPSLTASpssrp 1647
Cdd:PRK12727   60 SDTPATAAAPAPAPQAPTKPAAPVHAPLKLSANANMSQRQRVASAAEDMIAAMALRQPVSVPRQAPAAAPVRAAS----- 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1648 VASPGAISRSPTSSGSHKAVLTPAVTKV--------ISRTGVPQPTQAQSASSPSTPlTVAGTAAEQVPVSPLATRSLEI 1719
Cdd:PRK12727  135 IPSPAAQALAHAAAVRTAPRQEHALSAVpeqlfadfLTTAPVPRAPVQAPVVAAPAP-VPAIAAALAAHAAYAQDDDEQL 213

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 636526419 1720 VlstekgEAGHSQPMGSPASPQPHPLPSAPPRPAQHTTMATRSPALP 1766
Cdd:PRK12727  214 D------DDGFDLDDALPQILPPAALPPIVVAPAAPAALAAVAAAAP 254
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1470-1753 2.18e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 53.64  E-value: 2.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1470 PPSQGLPTPSD--EEPQLSQESPRTPTHRPALTPAAPLTTALNPP-----------VTATEEPVVSPGPTQTTLQQPLEL 1536
Cdd:PHA03307  123 PASPPPSPAPDlsEMLRPVGSPGPPPAASPPAAGASPAAVASDAAssrqaalplssPEETARAPSSPPAEPPPSTPPAAA 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1537 TASQLPAGPTESPASKGVTASLLAIPHTPESSSLPVALQTPTPGMVSGAMETTRV---------TVIFAGSPNI------ 1601
Cdd:PHA03307  203 SPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLprpapitlpTRIWEASGWNgpssrp 282

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1602 -TVSSRSPPAPRFPlmtkaVTVRGHGSLPVRTTPP---------QPSLTASPSSRPVASPGAISRSPTSSGSH------K 1665
Cdd:PHA03307  283 gPASSSSSPRERSP-----SPSPSSPGSGPAPSSPrasssssssRESSSSSTSSSSESSRGAAVSPGPSPSRSpspsrpP 357

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1666 AVLTPAVTKVISRTGVPQPTQAQSASSPSTPLTVAGTAAEQVP--VSPLATRSLEIVLSTEKGEAGHSQPM-GSPASPQP 1742
Cdd:PHA03307  358 PPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRrdATGRFPAGRPRPSPLDAGAASGAFYArYPLLTPSG 437

                         330
                  ....*....|.
gi 636526419 1743 HPLPSAPPRPA 1753
Cdd:PHA03307  438 EPWPGSPPPPP 448
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 1753-2011 2.38e-06

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 53.04  E-value: 2.38e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1753 AQHTTMATRSPALPPETPAAASLSTATDglAATpfmsLESTRPSQLLSGLPPDTSLPLAKVGTSAPVATPGPKASVITTP 1832
Cdd:pfam17823   50 ADNKSSEQ*NFCAATAAPAPVTLTKGTS--AAH----LNSTEVTAEHTPHGTDLSEPATREGAADGAASRALAAAASSSP 123

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1833 LQPQATTLPAQTLSPVLPFT--------------PAAMTQAHPPTHIAPPAAGTAPGLLLGATLPTSGVLPVAEGTASMV 1898
Cdd:pfam17823  124 SSAAQSLPAAIAALPSEAFSapraaacranasaaPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTAASSAP 203

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1899 S-VVP-RKSTTGKVAILSKQVSLPTSMYGSAEGGPTELTPA--TSHPLT-PLVAEPEGAQAGTALPVPTSYALSRV--SA 1971
Cdd:pfam17823  204 AtLTPaRGISTAATATGHPAAGTALAAVGNSSPAAGTVTAAvgTVTPAAlATLAAAAGTVASAAGTINMGDPHARRlsPA 283

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 636526419  1972 RTAPQDSMLV--LLPQLAEAHGTSAGPHLaAEPVDEATTEPS 2011
Cdd:pfam17823  284 KHMPSDTMARnpAAPMGAQAQGPIIQVST-DQPVHNTAGEPT 324
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1736-1989 3.00e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 52.96  E-value: 3.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1736 SPASPQPHPLPSAPPrPAQHTTMATRSPALPPETPAAASLSTAtdglAATPFMSLESTRPSQLLSGLPPDTSLPLAKVGT 1815
Cdd:PRK12323  373 GPATAAAAPVAQPAP-AAAAPAAAAPAPAAPPAAPAAAPAAAA----AARAVAAAPARRSPAPEALAAARQASARGPGGA 447

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1816 SAPV----ATPGPKASVITTPLQPQATTLPAQTLSPVLPFTPAAMTQAHPPTHIAPPA--------AGTAPGLLLGATLP 1883
Cdd:PRK12323  448 PAPApapaAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEfaspapaqPDAAPAGWVAESIP 527

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1884 TSGVLPvAEGTASMVSVVPRKSTTGKVAILSKQVSLPTSMYGSAEGGPTELTP-----ATSHPLTPLVAEpegaqagtal 1958
Cdd:PRK12323  528 DPATAD-PDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGdwpalAARLPVRGLAQQ---------- 596

                         250       260       270
                  ....*....|....*....|....*....|....
gi 636526419 1959 pvptsyaLSRVSARTAPQDSMLVL---LPQLAEA 1989
Cdd:PRK12323  597 -------LARQSELAGVEGDTVRLrvpVPALAEA 623
DUF4045 pfam13254
Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. ...
 1469-1829 3.25e-06

Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. This domain family is found in bacteria and eukaryotes, and is typically between 384 and 430 amino acids in length.


Pssm-ID: 433066 [Multi-domain]  Cd Length: 415  Bit Score: 52.48  E-value: 3.25e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1469 LPPSQGLPTPSDEEPQLSQESPRTPTHRPA-----LTPAAPLTTAlNPPVTATEEPVvspgptqttlqqpleltasqLPA 1543
Cdd:pfam13254   49 VAGPSGSLSPGLSPTKLSREGSPESTSRPSsshseATIVRHSKDD-ERPSTPDEGFV--------------------KPA 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1544 GPTESPASKGVTASllaiPHTPESSSLPValqtpTPGMVSGAMETTRvtvifaGSPniTVSS---------RSPPAPRFP 1614
Cdd:pfam13254  108 LPRHSRSSSALSNT----GSEEDSPSLPT-----SPPSPSKTMDPKR------WSP--TKSSwlesalnrpESPKPKAQP 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1615 lmtkavtvrghgslpvrTTPPQPSLTASpssrpvaspgaISRSPTSSGSHKavLT-PAVTKVISRTGVPQPTQAQSASSP 1693
Cdd:pfam13254  171 -----------------SQPAQPAWMKE-----------LNKIRQSRASVD--LGrPNSFKEVTPVGLMRSPAPGGHSKS 220

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1694 StplTVAGTAAEQVPVSPlatrsleivlstekGEAGHSQPMGSPASPQPHPLPSAPPRPAQHTTMATRSPALPPETPAAA 1773
Cdd:pfam13254  221 P---SVSGISADSSPTKE--------------EPSEEADTLSTDKEQSPAPTSASEPPPKTKELPKDSEEPAAPSKSAEA 283

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 636526419  1774 SLSTATDGLAATPFMSLESTRPSQLLSGLPPDTSLPLAKVGTSAPVATPGPKASVI 1829
Cdd:pfam13254  284 STEKKEPDTESSPETSSEKSAPSLLSPVSKASIDKPLSSPDRDPLSPKPKPQSPPK 339
FimV COG3170
Type IV pilus assembly protein FimV [Cell motility, Extracellular structures];
1619-2027 7.66e-06

Type IV pilus assembly protein FimV [Cell motility, Extracellular structures];


Pssm-ID: 442403 [Multi-domain]  Cd Length: 508  Bit Score: 51.33  E-value: 7.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1619 AVTVRGHGSLPVRTTppqpsltaspSSRPVASP------------GAISRSPTssgshkAVLTPAVTKVISRTgvPQPTQ 1686
Cdd:COG3170    59 AVERRADGRPVLRVT----------SSRPVNEPfldflvevnwpsGRLVREYT------LLLDPPAYAAAAAA--PAAAP 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1687 AQSASSPSTPltvagTAAEQVPVSPLATRSLEIVLSTEKGEAghsqpMGSPASpqphplpsAPPRPAQHTTMATRSPALP 1766
Cdd:COG3170   121 APAPAAPAAA-----AAAADQPAAEAAPAASGEYYPVRPGDT-----LWSIAA--------RPVRPSSGVSLDQMMVALY 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1767 PETPAA------------ASLST-ATDGLAATPfmSLESTRPSQLLSGLPPDTSLPLAKVGTSAPVATPGPKASvittPL 1833
Cdd:COG3170   183 RANPDAfidgninrlkagAVLRVpAAEEVAALS--PAEARQEVQAQSADWAAYRARLAAAVEPAPAAAAPAAPP----AA 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1834 QPQATTLPAQTLSPVlpfTPAAMTQAHPPTHIAPPAAGTapglllgatlptsgvlPVAEGTASMVSvvprksttgKVAIL 1913
Cdd:COG3170   257 AAAAGPVPAAAEDTL---SPEVTAAAAAEEADALPEAAA----------------ELAERLAALEA---------QLAEL 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1914 SKQVSLPTSMYGSAEGGPTELTPATSHPLTPLVAEPEGAQA----GTALPVPTSYALSRVSARTAPQDSMlvllpQLAEA 1989
Cdd:COG3170   309 QRLLALKNPAPAAAVSAPAAAAAAATVEAAAPAAAAQPAAAapapALDNPLLLAGLLRRRKAEADEVDPV-----AEADV 383

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 636526419 1990 HGTSAGPHLAAEPVDEATTEPSGRSAPALSIVEGLAEA 2027
Cdd:COG3170   384 YLAYGRDDQAEEILKEALASEPERLDLRLKLLEIYAAR 421
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 1413-1670 1.35e-05

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 50.70  E-value: 1.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1413 RDPRAASCRDVPRV-EGCVPVCPTPQVLDEV-TQRcvyledcVEPAVwvPTEALGNETLPPSQGLP----TPSDEEP-QL 1485
Cdd:PLN03209  293 KNRRLSYCKVVEVIaETTAPLTPMEELLAKIpSQR-------VPPKE--SDAADGPKPVPTKPVTPeapsPPIEEEPpQP 363

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1486 SQESPRtpthrpaltpaaPLTtalnpPVTATEE--PVVSPGPTQTT--LQQPLELTASQLPAGPTESPASKGVTASLLAI 1561
Cdd:PLN03209  364 KAVVPR------------PLS-----PYTAYEDlkPPTSPIPTPPSssPASSKSVDAVAKPAEPDVVPSPGSASNVPEVE 426

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1562 PHTPESSSL-------------PVALQTPTP--GMVSGAMETTRVTVIFAGSPNITVSSRSPPAPRFPLMTKAVTVRGHG 1626
Cdd:PLN03209  427 PAQVEAKKTrplspyaryedlkPPTSPSPTAptGVSPSVSSTSSVPAVPDTAPATAATDAAAPPPANMRPLSPYAVYDDL 506

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 636526419 1627 SLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTP 1670
Cdd:PLN03209  507 KPPTSPSPAAPVGKVAPSSTNEVVKVGNSAPPTALADEQHHAQP 550
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 1635-1753 1.74e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 50.48  E-value: 1.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1635 PQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAVTKVIsrtgVPQPTQAQSASsPSTPLTVAGTAAEQVPVSPLAT 1714
Cdd:PRK14951  373 AAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAP----AAPPAAAPPAP-VAAPAAAAPAAAPAAAPAAVAL 447

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 636526419 1715 RSLEIVLSTEKGEAGHSQPMGSPASPQPHPLPSAPPRPA 1753
Cdd:PRK14951  448 APAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAA 486
SAP130_C pfam16014
Histone deacetylase complex subunit SAP130 C-terminus;
1738-1939 2.18e-05

Histone deacetylase complex subunit SAP130 C-terminus;


Pssm-ID: 464973 [Multi-domain]  Cd Length: 371  Bit Score: 49.55  E-value: 2.18e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1738 ASPQPHPLPSAP------PRPAQHTTMAtrspalPPETPAAASLStatdglaatpfmsleSTRPSQLLSGLPPDTSLPLA 1811
Cdd:pfam16014    4 SSPRPSILRKKPategakPKPDIHVAVA------PPVTVAVEALP---------------GQNSEQQTASASPPSQHPAQ 62

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1812 KVGTSAPVATPgpkasvittPLQPQATTLPAQTLSPVLPFTPAAMTQ-AHPPTHiapPAAGTAPGLLLGATLPTSGVLPV 1890
Cdd:pfam16014   63 AIPTILAPAAP---------PSQPSVVLSTLPAAMAVTPPIPASMANvVAPPTQ---PAASSTAACAVSSVLPEIKIKQE 130

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 636526419  1891 AEGTASMVSVVPRKSTTGKVAILSKQVSLPTSmygsaeggPTELTPATS 1939
Cdd:pfam16014  131 AEPMDTSQSVPPLTPTSISPALTSLANNLSVP--------AGDLLPGAS 171
PRK11901 PRK11901
hypothetical protein; Reviewed
 1573-1786 2.33e-05

hypothetical protein; Reviewed


Pssm-ID: 237015 [Multi-domain]  Cd Length: 327  Bit Score: 49.30  E-value: 2.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1573 ALQTPTPGMVSGAMETTrvtvifAGSPNITVSSRSPpaprfplMTKavtvrGHGSLPVRTTPPQPSLTASPSSrPVASPG 1652
Cdd:PRK11901   57 ALKSPTEHESQQSSNNA------GAEKNIDLSGSSS-------LSS-----GNQSSPSAANNTSDGHDASGVK-NTAPPQ 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1653 AISRSPTSSGSHKA--VLTPA----------VTKVISRT-----GVPQPTQAQSASSPSTPLTVAGTAAEQVPVSPlatr 1715
Cdd:PRK11901  118 DISAPPISPTPTQAapPQTPNgqqrielpgnISDALSQQqgqvnAASQNAQGNTSTLPTAPATVAPSKGAKVPATA---- 193

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 636526419 1716 sleivlstekgeaghsqpmgsPASPQPHPLPSAPPRPAQHTTMATRSPAlPPETPAAASLSTATDGLAATP 1786
Cdd:PRK11901  194 ---------------------ETHPTPPQKPATKKPAVNHHKTATVAVP-PATSGKPKSGAASARALSSAP 242
PHA03379 PHA03379
EBNA-3A; Provisional
 1453-1871 3.10e-05

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 49.67  E-value: 3.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1453 VEPaVWVPTEALGNETLP-PSQGLPTPSDEEPQLSQESPRtptHRPAltPAAPlttalNPPVTATEEPV---VSPG-PTQ 1527
Cdd:PHA03379  531 VEP-VPVPTVALERPVCPaPPLIAMQGPGETSGIVRVRER---WRPA--PWTP-----NPPRSPSQMSVrdrLARLrAEA 599

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1528 TTLQQPLELTASQLPAGPTESPASKgvtasllaiPHTPESSSLPVALQTptpgMVSGAMETTRVTVIfagspnitvssrS 1607
Cdd:PHA03379  600 QPYQASVEVQPPQLTQVSPQQPMEY---------PLEPEQQMFPGSPFS----QVADVMRAGGVPAM------------Q 654

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1608 PPAPRFPLmTKAVTVRG------HGSLPVrttPPQPSLTASPSSRPVASPGAISrsptSSGSHKAVLTPAvtkvisrTGV 1681
Cdd:PHA03379  655 PQYFDLPL-QQPISQGAplaplrASMGPV---PPVPATQPQYFDIPLTEPINQG----ASAAHFLPQQPM-------EGP 719

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1682 PQPTQAQSASSPSTPLTVAGTAAEQVPVSPLaTRSleIVLSTEKGEAGHSQPMGSPASPQPHPLPSAPPRP----AQHTT 1757
Cdd:PHA03379  720 LVPERWMFQGATLSQSVRPGVAQSQYFDLPL-TQP--INHGAPAAHFLHQPPMEGPWVPEQWMFQGAPPSQgtdvVQHQL 796

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1758 MATRSPAL---PPETPAAAS-----LSTATDGLAATPFMSLESTRPSQllsglpPDTSLPLAKVGTSAPVAtpgPKASVI 1829
Cdd:PHA03379  797 DALGYVLHvlnHPGVPVSPAvnqyhVSQAAFGLPIDEDESGEGSDTSE------PCEALDLSIHGRPCPQA---PEWPVQ 867

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 636526419 1830 TTPLQPQATTLPAQTLSPVLPFTPAAMTQAHPPTHIAPPAAG 1871
Cdd:PHA03379  868 GEGGQDATEVLDLSIHGRPRPRTPEWPVQGEDGQNVTGAESR 909
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 1646-1781 3.93e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 49.33  E-value: 3.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1646 RPVASPGAISRSPTSSGSHKAVLTPAVTKVISRT--GVPQPTQAQSASSPSTPLTVAGTAAEQVP--VSPLATRsleivl 1721
Cdd:PRK14951  365 KPAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAaaPAPAAAPAAAASAPAAPPAAAPPAPVAAPaaAAPAAAP------ 438

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1722 stEKGEAghSQPMGSPASPQPHPLPSAPPRPAQHTTMATRSPALPPETPAAASLSTATDG 1781
Cdd:PRK14951  439 --AAAPA--AVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEEG 494
PRK12727 PRK12727
flagellar biosynthesis protein FlhF;
1686-1874 4.89e-05

flagellar biosynthesis protein FlhF;


Pssm-ID: 237182 [Multi-domain]  Cd Length: 559  Bit Score: 48.83  E-value: 4.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1686 QAQSASSPSTPLTVAGTAAEQVPVSPLATRSLEIVLSTEKGEAGHSQPMGSPASP--------QPHPLPSAPPRPAQHTT 1757
Cdd:PRK12727   53 RALETARSDTPATAAAPAPAPQAPTKPAAPVHAPLKLSANANMSQRQRVASAAEDmiaamalrQPVSVPRQAPAAAPVRA 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1758 MATRSPALPPETPAAAslstatdGLAATPFMSLESTRPSQLLSGLP-----PDTSLPLAKVGTSAPVAT-PGPKASVITT 1831
Cdd:PRK12727  133 ASIPSPAAQALAHAAA-------VRTAPRQEHALSAVPEQLFADFLttapvPRAPVQAPVVAAPAPVPAiAAALAAHAAY 205

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 636526419 1832 ------PLQPQATTL---PAQTLSPVlPFTPAAMTQAHPPTHIAPPAAGTAP 1874
Cdd:PRK12727  206 aqdddeQLDDDGFDLddaLPQILPPA-ALPPIVVAPAAPAALAAVAAAAPAP 256
FimV COG3170
Type IV pilus assembly protein FimV [Cell motility, Extracellular structures];
1499-1773 5.44e-05

Type IV pilus assembly protein FimV [Cell motility, Extracellular structures];


Pssm-ID: 442403 [Multi-domain]  Cd Length: 508  Bit Score: 48.64  E-value: 5.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1499 LTPAAPLTTALNPPVTATEEPVvSPGPTQTTLQQPLelTASQLPAGPTESPASKGVTASLLA-IPHTPESS-SLP---VA 1573
Cdd:COG3170   104 LDPPAYAAAAAAPAAAPAPAPA-APAAAAAAADQPA--AEAAPAASGEYYPVRPGDTLWSIAaRPVRPSSGvSLDqmmVA 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1574 LQTPTPGMVSG----AMETTRVTVIFAGSpniTVSSRSPPAPRFPLMTKAVTVRGHGSLPVRTTPPQPSLTASPSSRPVA 1649
Cdd:COG3170   181 LYRANPDAFIDgninRLKAGAVLRVPAAE---EVAALSPAEARQEVQAQSADWAAYRARLAAAVEPAPAAAAPAAPPAAA 257

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1650 SPGAisrsptssgshkavltpavtkvisrtgvPQPTQAQSASSPSTPltvAGTAAEQVPVSPLATRSLEIVLSTEKGEAG 1729
Cdd:COG3170   258 AAAG----------------------------PVPAAAEDTLSPEVT---AAAAAEEADALPEAAAELAERLAALEAQLA 306

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 636526419 1730 HSQPMGSPASPQPHPLPSAPPRPAQHTTMATRSPALPPETPAAA 1773
Cdd:COG3170   307 ELQRLLALKNPAPAAAVSAPAAAAAAATVEAAAPAAAAQPAAAA 350
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 414-462 5.57e-05

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 43.14  E-value: 5.57e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 636526419   414 TYNECIACCPASC---HPRASCvdsEIACVDGCYCPNGLIFEDGG-CVAPAEC 462
Cdd:pfam01826    6 VYSECGSACPPTCanlSPPDVC---PEPCVEGCVCPPGFVRNSGGkCVPPSDC 55
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 1527-1805 6.29e-05

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 48.31  E-value: 6.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1527 QTTLQQPLELTASQLPAGPTESPASKGVTASLLAIPHTPesssLPVALQTPTPGMVSGAMETTRVTVIFAGSPNITVSSR 1606
Cdd:COG3266   112 AAALLLLKLLLLLLTLLLLVLLLLLALLLALLLDLPLLT----LLIVLPLLEEQLLLLALQDIQGTLQALGAVAALLGLR 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1607 SPPAPRFPLMTKAVTVRGHGSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLtpavtkvISRTGVPQPTQ 1686
Cdd:COG3266   188 KAEEALALRAGSAAADALALLLLLLASALGEAVAAAAELAALALLAAGAAEVLTARLVLLLL-------IIGSALKAPSQ 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1687 AQSASSPSTPLTVAGTAAEQVPVSPLATrsleiVLSTEKGEAGHSQPMgSPASPQPHPLPSAPPRPAQHTTMATRSPALP 1766
Cdd:COG3266   261 ASSASAPATTSLGEQQEVSLPPAVAAQP-----AAAAAAQPSAVALPA-APAAAAAAAAPAEAAAPQPTAAKPVVTETAA 334

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 636526419 1767 PETPAAASLSTATdgLAATPFMSLESTRPSQLLSGLPPD 1805
Cdd:COG3266   335 PAAPAPEAAAAAA--APAAPAVAKKLAADEQWLASQPAS 371
TIL pfam01826
Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well ...
 2361-2422 6.58e-05

Trypsin Inhibitor like cysteine rich domain; This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.


Pssm-ID: 460351  Cd Length: 55  Bit Score: 42.76  E-value: 6.58e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 636526419  2361 CSSDSTYQACVTACEPpkTCQDGILGPLDPEHCQvlgEGCVCSEGTILHRRHSalCIPEAKC 2422
Cdd:pfam01826    1 CPANEVYSECGSACPP--TCANLSPPDVCPEPCV---EGCVCPPGFVRNSGGK--CVPPSDC 55
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 2361-2422 6.64e-05

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 42.69  E-value: 6.64e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 636526419 2361 CSSDSTYQACVTACEPpkTCQDGILGPLDPEHCQvlgEGCVCSEGTILHRRHSalCIPEAKC 2422
Cdd:cd19941     1 CPPNEVYSECGSACPP--TCANPNAPPPCTKQCV---EGCFCPEGYVRNSGGK--CVPPSQC 55
PHA03379 PHA03379
EBNA-3A; Provisional
 1712-1984 6.69e-05

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 48.52  E-value: 6.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1712 LATRSLEIVLSTEKGEAGHSQPM-GSPASPQPHPLPSAPPRPAQHTTMAT-RSPALPPETPAAASLSTATDGLAATPFMS 1789
Cdd:PHA03379  390 LLMRAGKLTERAREALEKASEPTyGTPRPPVEKPRPEVPQSLETATSHGSaQVPEPPPVHDLEPGPLHDQHSMAPCPVAQ 469

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1790 LEST-----RPSQLLSGLPPDtslplakvGTSAPVATPGPkASVITTPLQPQATTLPAQTLSPVLP------FTPAAMTQ 1858
Cdd:PHA03379  470 LPPGplqdlEPGDQLPGVVQD--------GRPACAPVPAP-AGPIVRPWEASLSQVPGVAFAPVMPqpmpvePVPVPTVA 540

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1859 AHPPTHIAPP-AAGTAPGlllgatlPTSGVLPVAEG------TASMVSVVPRKSTTGKVAILSKQVSLPTSmygSAEGGP 1931
Cdd:PHA03379  541 LERPVCPAPPlIAMQGPG-------ETSGIVRVRERwrpapwTPNPPRSPSQMSVRDRLARLRAEAQPYQA---SVEVQP 610

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 636526419 1932 TELTPA-TSHPLT-PLVAEPEGAQAGTALPVPTSYALSRVSARTAPQDSMLVLLP 1984
Cdd:PHA03379  611 PQLTQVsPQQPMEyPLEPEQQMFPGSPFSQVADVMRAGGVPAMQPQYFDLPLQQP 665
PRK12727 PRK12727
flagellar biosynthesis protein FlhF;
1621-1836 9.04e-05

flagellar biosynthesis protein FlhF;


Pssm-ID: 237182 [Multi-domain]  Cd Length: 559  Bit Score: 48.06  E-value: 9.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1621 TVRGHGSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAVTKVISRT-------GVPQPTQAQSASSP 1693
Cdd:PRK12727   57 TARSDTPATAAAPAPAPQAPTKPAAPVHAPLKLSANANMSQRQRVASAAEDMIAAMALRqpvsvprQAPAAAPVRAASIP 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1694 StPLTVAGTAAEQVPVSPLATRSLeivlsTEKGEAGHSQPMGSPASPqphplpsAPPRPAQHTTMATRSPALPPETPAAA 1773
Cdd:PRK12727  137 S-PAAQALAHAAAVRTAPRQEHAL-----SAVPEQLFADFLTTAPVP-------RAPVQAPVVAAPAPVPAIAAALAAHA 203

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 636526419 1774 SLSTATDGLAATPFMSLESTRPSQLlsglpPDTSLPLAKVgtsAPVATPGPKASVITTPlQPQ 1836
Cdd:PRK12727  204 AYAQDDDEQLDDDGFDLDDALPQIL-----PPAALPPIVV---APAAPAALAAVAAAAP-APQ 257
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1602-1804 9.41e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 47.95  E-value: 9.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1602 TVSSRSPPAPRFPLMTKAVTVRGHGSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAvltPAVTKVisrtGV 1681
Cdd:PRK12323  385 PAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPA---PAPAPA----AA 457

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1682 PQPTQAQSASSPSTPltvagtAAEQVPVSPLATRSLEIVLSTEKGEAGHSQPmGSPASPQPHPLPSAPPRPAQHTTM--A 1759
Cdd:PRK12323  458 PAAAARPAAAGPRPV------AAAAAAAPARAAPAAAPAPADDDPPPWEELP-PEFASPAPAQPDAAPAGWVAESIPdpA 530

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 636526419 1760 TRSPALPPETPAAASLSTATDGLAATPFMSLESTRPSQLLSGLPP 1804
Cdd:PRK12323  531 TADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPD 575
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 414-462 9.46e-05

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 42.30  E-value: 9.46e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 636526419  414 TYNECIACCPASCHPRASCVDSEIACVDGCYCPNGLIFEDGG-CVAPAEC 462
Cdd:cd19941     6 VYSECGSACPPTCANPNAPPPCTKQCVEGCFCPEGYVRNSGGkCVPPSQC 55
PRK10905 PRK10905
cell division protein DamX; Validated
 1476-1662 1.61e-04

cell division protein DamX; Validated


Pssm-ID: 236792 [Multi-domain]  Cd Length: 328  Bit Score: 46.47  E-value: 1.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1476 PTPSDEEPQLSQE-----SPRTPTHRPALTPAAPLTTALNPPVTATEE---PVVSPGPTQ------TTLQQPLE------ 1535
Cdd:PRK10905   23 PSTSSSDQTASGEksidlAGNATDQANGVQPAPGTTSAEQTAGNTQQDvslPPISSTPTQgqtpvaTDGQQRVEvqgdln 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1536 --LTASQLPAG----------PTEsPASKGVTASLLAIPHTPESSSLPVAlQTPTPgmvsgameTTRVTVIFAGSPNITV 1603
Cdd:PRK10905  103 naLTQPQNQQQlnnvavnstlPTE-PATVAPVRNGNASRQTAKTQTAERP-ATTRP--------ARKQAVIEPKKPQATA 172

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 636526419 1604 SSRSPPAPRFPLMTKAVTVRGHGSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSG 1662
Cdd:PRK10905  173 KTEPKPVAQTPKRTEPAAPVASTKAPAATSTPAPKETATTAPVQTASPAQTTATPAAGG 231
PHA03369 PHA03369
capsid maturational protease; Provisional
 1634-1959 1.63e-04

capsid maturational protease; Provisional


Pssm-ID: 223061 [Multi-domain]  Cd Length: 663  Bit Score: 47.30  E-value: 1.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1634 PPQPSLTASPSSRPVASPGAISRSPTSSGShkaVLTPAVTKVISRTGVPQPTQAQSASSPSTPLTVAGtaaeqVPVSPLA 1713
Cdd:PHA03369  371 APQTHTGPADRQRPQRPDGIPYSVPARSPM---TAYPPVPQFCGDPGLVSPYNPQSPGTSYGPEPVGP-----VPPQPTN 442

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1714 TRSLEIVLSTekgeaghsqpMGSPASPQPHPLPSAPPRP----AQHTTMATRSPALPPETPAAASLSTAtdglaatpfMS 1789
Cdd:PHA03369  443 PYVMPISMAN----------MVYPGHPQEHGHERKRKRGgelkEELIETLKLVKKLKEEQESLAKELEA---------TA 503

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1790 LESTRPSQLLSGLPPdtslplAKVGTSAPVATPGPKASViTTPLQPQATTLPAQTLSPVLPFtPAAMTQAHPPTHIAPPA 1869
Cdd:PHA03369  504 HKSEIKKIAESEFKN------AGAKTAAANIEPNCSADA-AAPATKRARPETKTELEAVVRF-PYQIRNMESPAFVHSFT 575

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1870 AGTAPGLllgatlpTSGVLPVAEGTASMVSVVPRKSTtgkvailskqvSLPTSMYGSAEGGPteLTPATSHPLTPLVAEP 1949
Cdd:PHA03369  576 STTLAAA-------AGQGSDTAEALAGAIETLLTQAS-----------AQPAGLSLPAPAVP--VNASTPASTPPPLAPQ 635

                         330
                  ....*....|
gi 636526419 1950 EGAQAGTALP 1959
Cdd:PHA03369  636 EPPQPGTSAP 645
PRK12727 PRK12727
flagellar biosynthesis protein FlhF;
1712-1900 1.83e-04

flagellar biosynthesis protein FlhF;


Pssm-ID: 237182 [Multi-domain]  Cd Length: 559  Bit Score: 46.91  E-value: 1.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1712 LATRSLEIVLSTEKGEAGHSQPMGSPASPQPHPLPSAPPRPAQH----------------TTMATRSPA-LPPETPAAAS 1774
Cdd:PRK12727   50 LVQRALETARSDTPATAAAPAPAPQAPTKPAAPVHAPLKLSANAnmsqrqrvasaaedmiAAMALRQPVsVPRQAPAAAP 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1775 LSTATDGLAATPFMSLEST-----RPSQLLSGLPPDTslpLAKVGTSAPVATPG--PKASVITTPLQPQATTLPAqtlsp 1847
Cdd:PRK12727  130 VRAASIPSPAAQALAHAAAvrtapRQEHALSAVPEQL---FADFLTTAPVPRAPvqAPVVAAPAPVPAIAAALAA----- 201

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 636526419 1848 vlPFTPA--AMTQAHPP--THIAPPAAGTAPglllgATLPTSGVLPVAEGTASMVSV 1900
Cdd:PRK12727  202 --HAAYAqdDDEQLDDDgfDLDDALPQILPP-----AALPPIVVAPAAPAALAAVAA 251
AlaDh_PNT_C smart01002
Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase catalyzes the ...
 2664-2724 2.11e-04

Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase catalyzes the NAD-dependent reversible reductive amination of pyruvate into alanine.


Pssm-ID: 214966 [Multi-domain]  Cd Length: 149  Bit Score: 44.03  E-value: 2.11e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 636526419   2664 GCAKYECVKAPVCLSRE-LGVMQPGQTVVELSAD--GVCHTSRCTTVLDPltnFYQINTTSVLC 2724
Cdd:smart01002   89 GAVLIPGAKAPKLVTREmVKSMKPGSVIVDVAADqgGCIETSRPTTHDDP---TYVVDGVVHYC 149
VWC_out smart00215
von Willebrand factor (vWF) type C domain;
464-499 2.22e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214565  Cd Length: 67  Bit Score: 41.78  E-value: 2.22e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 636526419    464 CEFHGTLYPPGSVVKEDCNTCTCTSGKWECSTAVCP 499
Cdd:smart00215    1 CWNNGSYYPPGAKWDDDCNRCTCLNGRVSCTKVWCG 36
PRK10905 PRK10905
cell division protein DamX; Validated
 1618-1796 2.52e-04

cell division protein DamX; Validated


Pssm-ID: 236792 [Multi-domain]  Cd Length: 328  Bit Score: 46.08  E-value: 2.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1618 KAVTVRGHGSLPVRTTPPQPSLT-----ASPSSRPVASPgAISRSPTSSGShkavltPAVTKVISRTGVP---------- 1682
Cdd:PRK10905   36 KSIDLAGNATDQANGVQPAPGTTsaeqtAGNTQQDVSLP-PISSTPTQGQT------PVATDGQQRVEVQgdlnnaltqp 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1683 -QPTQAQSASSPST----PLTVA----GTAAEQVPVSPLATRSL-------EIVLSTEKGEAGHSQPMGSPASPQPHPLP 1746
Cdd:PRK10905  109 qNQQQLNNVAVNSTlptePATVApvrnGNASRQTAKTQTAERPAttrparkQAVIEPKKPQATAKTEPKPVAQTPKRTEP 188

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1747 SAPPRPAqhTTMATRSPALPPET----------PAAASLSTATDGLAATPFMSLESTrPS 1796
Cdd:PRK10905  189 AAPVAST--KAPAATSTPAPKETattapvqtasPAQTTATPAAGGKTAGNVGSLKSA-PS 245
PRK10905 PRK10905
cell division protein DamX; Validated
 1749-1855 3.00e-04

cell division protein DamX; Validated


Pssm-ID: 236792 [Multi-domain]  Cd Length: 328  Bit Score: 45.70  E-value: 3.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1749 PPRPAqhTTMATRSPALPPETPAAASLSTATDGLAATPFMSLESTRPSQLLSGLPPDTSLPLAKVGTSAPVATPGPKASV 1828
Cdd:PRK10905  124 PTEPA--TVAPVRNGNASRQTAKTQTAERPATTRPARKQAVIEPKKPQATAKTEPKPVAQTPKRTEPAAPVASTKAPAAT 201

                          90       100
                  ....*....|....*....|....*..
gi 636526419 1829 ITTPLQPQATTLPAQTLSPVLPFTPAA 1855
Cdd:PRK10905  202 STPAPKETATTAPVQTASPAQTTATPA 228
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 1459-1639 3.06e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 46.11  E-value: 3.06e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1459 VPTEALGNETLPPSQGLPTPSDEEPQLSQESPRTPTHRPALTPAAPLTTALNPPVTATEEPVVSPGPTQTTLQQPLELTA 1538
Cdd:pfam17823  263 VASAAGTINMGDPHARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQVSTDQPVHNTAGEPTPSPSNTTLEPNTPKSVAS 342

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1539 SQLPAGPTESPASKGVTASLLAIPHT---PE---------SSSLPVALQTPTPGMVSGAMET-TRVTvifAGSPNITVSS 1605
Cdd:pfam17823  343 TNLAVVTTTKAQAKEPSASPVPVLHTsmiPEveatspttqPSPLLPTQGAAGPGILLAPEQVaTEAT---AGTASAGPTP 419

                          170       180       190
                   ....*....|....*....|....*....|....
gi 636526419  1606 RSPPAPRFPLMTKAVTVRGHGSLPVRTTPPQPSL 1639
Cdd:pfam17823  420 RSSGDPKTLAMASCQLSTQGQYLVVTTDPLTPAL 453
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1600-2016 3.32e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.70  E-value: 3.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1600 NITVSSRSPPAPRFPLMTKAVTVRGHGSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGshkavlTPAVTKVISRT 1679
Cdd:PHA03307   24 PPATPGDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRS------TPTWSLSTLAP 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1680 GVPQPTQAQSASSPSTPltvAGTAAEQVPVSPLAT----RSLEIVLSTEKGEAGHSQPMGSPASPQPHPLPSAPPRPAQH 1755
Cdd:PHA03307   98 ASPAREGSPTPPGPSSP---DPPPPTPPPASPPPSpapdLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAAL 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1756 TTMATRSPALPPETPaAASLSTATDGLAATPFMSLEStRPSQLLSGLPPDTSLPLAKVGTSAPVATPGPKASVITTPLQP 1835
Cdd:PHA03307  175 PLSSPEETARAPSSP-PAEPPPSTPPAAASPRPPRRS-SPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPE 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1836 QATTLPAQTLSPVLPFTPAAMTQAHPPTHIAPPAAGTAPGLLLGATLPTSGVLPVAEGTASMVSVVPRKSTTGKVAILSk 1915
Cdd:PHA03307  253 NECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSS- 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1916 qvSLPTSMYGSAEGGPTELTPATSHPLTPLVAEPEGAQAGTALPVPTSYALSrvSARTAPQDSMLVLLPQLAEAHGTSAG 1995
Cdd:PHA03307  332 --SSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAAS--AGRPTRRRARAAVAGRARRRDATGRF 407

                         410       420
                  ....*....|....*....|.
gi 636526419 1996 PHLAAEPVDEATTEPSGRSAP 2016
Cdd:PHA03307  408 PAGRPRPSPLDAGAASGAFYA 428
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 1737-1869 3.49e-04

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 45.53  E-value: 3.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1737 PASPQPH--PLPSAPPRPAQHTTMATRSPALPPETPAAASLSTATDGLAATPFMSLESTRPSQLLSGLPPDTSLPLAKVG 1814
Cdd:NF040712  192 FGRPLRPlaTVPRLAREPADARPEEVEPAPAAEGAPATDSDPAEAGTPDDLASARRRRAGVEQPEDEPVGPGAAPAAEPD 271

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 636526419 1815 TSAPVATPGPkASVITTPLQPQATTLPAQTlSPVLPFTPAAMTQAHPPTHIAPPA 1869
Cdd:NF040712  272 EATRDAGEPP-APGAAETPEAAEPPAPAPA-APAAPAAPEAEEPARPEPPPAPKP 324
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 1732-1874 4.04e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 46.01  E-value: 4.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1732 QPMGSPASPQPHPLPSAPPRPAQHTTMATRSPALPPETPAAASLSTATDGLAATPfmSLESTRPSQ-------LLSGLPP 1804
Cdd:PRK07994  373 QSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQ--QLQRAQGATkakksepAAASRAR 450

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 636526419 1805 DTSLPLAKVGTSAPVATPGPKASVITTPLQPQATTLPAQTLSPVLpfTPAAMTQA--HPPThiAPPAAGTAP 1874
Cdd:PRK07994  451 PVNSALERLASVRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVA--TPKALKKAleHEKT--PELAAKLAA 518
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 1632-1757 6.55e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 45.09  E-value: 6.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1632 TTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAvtkvisrtgVPQPTQAQSASSPSTPLTVAGTAAEQVPVSP 1711
Cdd:PRK14951  382 ARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAA---------PPAPVAAPAAAAPAAAPAAAPAAVALAPAPP 452

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 636526419 1712 L--ATRSLEIVLSTEKGEAGHSQPMGSPASPQPHPLPSAPPRPAQHTT 1757
Cdd:PRK14951  453 AqaAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEEGDVWHAT 500
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 1618-1938 6.57e-04

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 45.30  E-value: 6.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1618 KAVTVRGHGSLPVrtTPPQPSLTASPSSRPvaspgaisrSPTSSGSHKAVlTPAVTKVisrtGVPQPTQAQSASSPSTPL 1697
Cdd:PLN03209  301 KVVEVIAETTAPL--TPMEELLAKIPSQRV---------PPKESDAADGP-KPVPTKP----VTPEAPSPPIEEEPPQPK 364

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1698 TVAgtaaeQVPVSPLATrsleivlstekgeaghSQPMGSPASPQPHPLPSAPPRPAQhtTMATRSPALPPETPAAASLSt 1777
Cdd:PLN03209  365 AVV-----PRPLSPYTA----------------YEDLKPPTSPIPTPPSSSPASSKS--VDAVAKPAEPDVVPSPGSAS- 420

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1778 atdGLAATPFMSLES--TRPsqlLSGL-------PPDTSLPLAKVGTSAPVATPgpkASVITTPLQPqattlpaqtlspv 1848
Cdd:PLN03209  421 ---NVPEVEPAQVEAkkTRP---LSPYaryedlkPPTSPSPTAPTGVSPSVSST---SSVPAVPDTA------------- 478

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1849 lPFTPAAMTQAHPPTHIAPPAAGTAPGLLLGATLPTSGVLPVAEGTASMVSVVPRKSTTGKVAILSKQVSL--------P 1920
Cdd:PLN03209  479 -PATAATDAAAPPPANMRPLSPYAVYDDLKPPTSPSPAAPVGKVAPSSTNEVVKVGNSAPPTALADEQHHAqpkprplsP 557

                         330
                  ....*....|....*...
gi 636526419 1921 TSMYGSAEgGPTELTPAT 1938
Cdd:PLN03209  558 YTMYEDLK-PPTSPTPSP 574
PHA01929 PHA01929
putative scaffolding protein
 1682-1786 8.10e-04

putative scaffolding protein


Pssm-ID: 177328  Cd Length: 306  Bit Score: 44.28  E-value: 8.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1682 PQPTQAQSASSPSTPLTVAGTAAEQVPvsplatrsleivlsTEKGEAGHSQPMGSPASPQ--PHPLPSAPPRPAQHTTMA 1759
Cdd:PHA01929   27 PQPNPVIQPQAPVQPGQPGAPQQLAIP--------------TQQPQPVPTSAMTPHVVQQapAQPAPAAPPAAGAALPEA 92

                          90       100
                  ....*....|....*....|....*..
gi 636526419 1760 TRSPALPPETPAAASLSTATDGLAATP 1786
Cdd:PHA01929   93 LEVPPPPAFTPNGEIVGTLAGNLEGDP 119
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 1596-1779 9.18e-04

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 44.06  E-value: 9.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1596 AGSPNITVSSRSPPAP--RFPlmtkavtvrghgslpvrTTPPQPSLTASPSSRPVASPGAISRSPTS--SGSHKAVLTPA 1671
Cdd:PLN02983   18 VGSRLSRSSFRLQPKPniSFP-----------------SKGPNPKRSAVPKVKAQLNEVAVDGSSNSakSDDPKSEVAPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1672 VTKVISRTGVPQPTQAQSASSPSTPLTVAGTAAEQVP---VSPLATRSLEIVLSTEKGEAGHSQPMGSPA----SPQPHP 1744
Cdd:PLN02983   81 EPKDEPPSNSSSKPNLPDEESISEFMTQVSSLVKLVDsrdIVELQLKQLDCELVIRKKEALPQPPPPAPVvmmqPPPPHA 160

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 636526419 1745 LPSAPPRPAQhtTMATRSPALPPETPAAASLSTAT 1779
Cdd:PLN02983  161 MPPASPPAAQ--PAPSAPASSPPPTPASPPPAKAP 193
AbfB pfam05270
Alpha-L-arabinofuranosidase B (ABFB) domain; This family consists of several fungal ...
 1293-1384 9.20e-04

Alpha-L-arabinofuranosidase B (ABFB) domain; This family consists of several fungal alpha-L-arabinofuranosidase B proteins. L-Arabinose is a constituent of plant-cell-wall poly-saccharides. It is found in a polymeric form in L-arabinan, in which the backbone is formed by 1,5-a- linked l-arabinose residues that can be branched via 1,2-a- and 1,3-a-linked l-arabinofuranose side chains. AbfB hydrolyses 1,5-a, 1,3-a and 1,2-a linkages in both oligosaccharides and polysaccharides, which contain terminal non-reducing l-arabinofuranoses in side chains.


Pssm-ID: 428401  Cd Length: 137  Bit Score: 41.76  E-value: 9.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1293 DPDVVSLEAADRPNFFL-HvtANGSLELAKWQGRDTFQQHASFLLHRGTRQAGLVALESLAKPSSFLYVSGAVLALRLYE 1371
Cdd:pfam05270   47 DSGCVSFESVNFPGSYLrH--YNFRLRLDANDGSALFREDATFCPRAGLGDSGSVSLESYNYPGRYIRHYNYELYIDPNG 124

                           90
                   ....*....|...
gi 636526419  1372 HTEVFRRGTLFRL 1384
Cdd:pfam05270  125 GTASFRADATFVV 137
C8 pfam08742
C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 ...
 2296-2357 9.64e-04

C8 domain; This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin. It is often found on proteins containing pfam00094 and pfam01826.


Pssm-ID: 462584  Cd Length: 68  Bit Score: 40.06  E-value: 9.64e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 636526419  2296 CLRMVSNRTFSACHRFVPPESFCELWIRDT----KYVQQPCVALTVYVAMCHKFHVCIE-WRRSDYC 2357
Cdd:pfam08742    2 CGLLSDSGPFAPCHSVVDPEPYFEACVYDMcscgGDDECLCAALAAYARACQAAGVCIGdWRTPTFC 68
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1484-1716 1.00e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.87  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1484 QLSQESPRTPTHRPALTPAAPLTTALNPPVTATEEPVvSPGPTQTTLQQPLELTASQLPAGPTESPASKGVTASLLAIPH 1563
Cdd:PRK12323  364 RPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPA-APPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASAR 442

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1564 TPESSSLPVALQTPTPGmvsgamettrvtvifAGSPNITVSSRSPPAPRFPLMTKAVtvrghgslPVRTTPPQPSLTASP 1643
Cdd:PRK12323  443 GPGGAPAPAPAPAAAPA---------------AAARPAAAGPRPVAAAAAAAPARAA--------PAAAPAPADDDPPPW 499

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 636526419 1644 SSRPVASPgAISRSPTSSGSHKAVLTPAVTKVISRTGVPQPTQAQSASSPSTPLTVAGTAAEQVPVSPLATRS 1716
Cdd:PRK12323  500 EELPPEFA-SPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASAS 571
Tymo_45kd_70kd pfam03251
Tymovirus 45/70Kd protein; Tymoviruses are single stranded RNA viruses. This family includes a ...
 1475-1766 2.15e-03

Tymovirus 45/70Kd protein; Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.


Pssm-ID: 281269 [Multi-domain]  Cd Length: 468  Bit Score: 43.24  E-value: 2.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1475 LPTPSDEEPQLSQESPRT-----------PTHRPALTPAApLTTALNPPVTATEEPVVSPGPTQTTLQQPLeLTASQLPA 1543
Cdd:pfam03251  150 LPSVPDHGPVLTETKPRTsvrqprsatrgPSFRPILLPKV-VHVHDDPPHSSLRPRGSRSRQLQPTVRRPL-LAPNQFHS 227

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1544 gPTESPASKGVTASLLAIPHTPESSSLPvalqtPTPGMVSGAMETTRVtvifagSPNITVSSRSPPAPRFPLMTKAVTVR 1623
Cdd:pfam03251  228 -PRQPPPLSDDPGILGPRPLAPHSTRDP-----PPRPITPGPSNTHDL------RPLSVLPRTSPRRGLLPNPRRHRTST 295

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1624 GHgsLPvRTTPPQPSLTASPSSRPV----ASPGAISRSPTSSGSHKAVLTPAVTKVISRTGVPQPTQAQSASSPST---- 1695
Cdd:pfam03251  296 GH--IP-PTTTSRPTGPPSRLQRPVhlyqSSPHTPNFRPSSIRKDALLQTGPRLGHLERLGQPANLRTSERSPPTKrrlp 372

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419  1696 ----------PLTVAGTAAEQ--------VPVSPLATRSleIVLSTEKGEAGHSQPMGS----PASPQPHPLPSAPPRPA 1753
Cdd:pfam03251  373 rssepnrlpkPLPEATLAPSYrhrrpyplLPNPPAALPS--IAYTSSRGKIHHSLPKGAlpkeGAPPPPRRLPSPAPRPQ 450

                          330
                   ....*....|...
gi 636526419  1754 QHTTMATRSPALP 1766
Cdd:pfam03251  451 LPLRDLGRTPGFP 463
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1622-1887 2.32e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 2.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1622 VRGHGSLPvrttPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAVTKV--ISRTGVPQPTQAQSASSPSTPLTV 1699
Cdd:PHA03247  248 LRGDIAAP----APPPVVGEGADRAPETARGATGPPPPPEAAAPNGAAAPPDGVwgAALAGAPLALPAPPDPPPPAPAGD 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1700 AGTAAEQVpvsplatRSLEIVLSTEKGEAGHsqPMGSPASPQPHPLP-------SAPPRPAQHTTMATRSPALPPE--TP 1770
Cdd:PHA03247  324 AEEEDDED-------GAMEVVSPLPRPRQHY--PLGFPKRRRPTWTPpssledlSAGRHHPKRASLPTRKRRSARHaaTP 394

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1771 AAASLSTATDGLAATPF-MSLESTRPSQLLSGLPPDTSLPLAKVGTSAPVATPGPKASVITTPLQPQATTLPAQTLSPVL 1849
Cdd:PHA03247  395 FARGPGGDDQTRPAAPVpASVPTPAPTPVPASAPPPPATPLPSAEPGSDDGPAPPPERQPPAPATEPAPDDPDDATRKAL 474

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 636526419 1850 PftpaAMTQAHPPthiAPPAAGTAPglLLGATLPTSGV 1887
Cdd:PHA03247  475 D----ALRERRPP---EPPGADLAE--LLGRHPDTAGT 503
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1794-2029 2.61e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.33  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1794 RPSQLLSGLPPDTSlplakvgTSAPVATPGPKASVittplqPQATTLPAQTLSPVLPFTPAAMTQAHPPTHiAPPAAGTA 1873
Cdd:PRK12323  364 RPGQSGGGAGPATA-------AAAPVAQPAPAAAA------PAAAAPAPAAPPAAPAAAPAAAAAARAVAA-APARRSPA 429

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1874 PGLLLGATLPTSGVLPVAEGTASMVSVVP----RKSTTGKVAILSKQVSLPTSMYGSAEGGPTELTPATSHPLTPLVAEP 1949
Cdd:PRK12323  430 PEALAAARQASARGPGGAPAPAPAPAAAPaaaaRPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASP 509

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1950 EGAQAGTALPVPTSYALSRVSARTAPQDSmlvllPQLAEAHGTSAGPHLAAEPVDEATTEPSGRSAPALSI--------- 2020
Cdd:PRK12323  510 APAQPDAAPAGWVAESIPDPATADPDDAF-----ETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDmfdgdwpal 584

                         250
                  ....*....|....
gi 636526419 2021 -----VEGLAEALA 2029
Cdd:PRK12323  585 aarlpVRGLAQQLA 598
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 1725-1898 2.73e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 43.16  E-value: 2.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1725 KGEAGHSQPMGSPASPqphPLPSAPPRPAQHTTMATRSPALPPETPAAASLSTATDGLAATPfmslestrpsqllsgLPP 1804
Cdd:PRK14951  365 KPAAAAEAAAPAEKKT---PARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPP---------------APV 426

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1805 DTSLPLAKVGTSAPVATPGPKASVITTPLQPQATTLPAQTLSPVLPFTPAAMTQAHPPthiAPPAAGTAPGLLLGATLPT 1884
Cdd:PRK14951  427 AAPAAAAPAAAPAAAPAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPA---AARLTPTEEGDVWHATVQQ 503

                         170
                  ....*....|....
gi 636526419 1885 sgvLPVAEGTASMV 1898
Cdd:PRK14951  504 ---LAAAEAITALA 514
TIL cd19941
trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich ...
 872-934 3.30e-03

trypsin inhibitor-like cysteine rich domain; TIL (trypsin inhibitor-like) cysteine rich domains are found in smapins (small serine proteinase inhibitor), or Ascaris trypsin inhibitor (ATI)-like proteins, whose members include anticoagulant proteins, elastase inhibitors, trypsin inhibitors, thrombin inhibitors, and chymotrypsin inhibitors. The TIL domain is also found in some large modular glycoproteins, including the von Willebrand factor (VWF), mucin-6, mucin-19, and SCO-spondin, among others. The TIL domain is characterized by the presence of five disulfide bonds (two of which are located on either side of the reactive site) in a single small protein domain of 61-62 residues. The cysteine residues that form the disulfide bonds are linked in the pattern: cysteines 1-7, 2-6, 3-5, 4-10 and 8-9. TILs can occur as a single domain or in multiple tandem arrangements. The disulfide bonds account for the unusual resistance to proteolysis and heat denaturation of these proteins. Smapins possess an unusual fold and, with the exception of the reactive site, shows no similarity to other serine protease inhibitors. The serine protease inhibitors comprise a large family of molecules involved in inflammatory responses, blood clotting, and complement activation.


Pssm-ID: 410995  Cd Length: 55  Bit Score: 38.07  E-value: 3.30e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 636526419  872 CPAGQVFVNCSDlhtdlelSRERTCEQqlLNLSVSARGPCLSGCACPQGLLRH-GDACFLPEEC 934
Cdd:cd19941     1 CPPNEVYSECGS-------ACPPTCAN--PNAPPPCTKQCVEGCFCPEGYVRNsGGKCVPPSQC 55
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1465-1713 3.37e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.94  E-value: 3.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1465 GNETLPPSQGLPTPSDEEPQLSQESPRTPT-HRPALTPAAPLTTALNPPVTATEEPVVSPGPTQTtlqqPLELTASQLPA 1543
Cdd:PRK12323  369 GGGAGPATAAAAPVAQPAPAAAAPAAAAPApAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEAL----AAARQASARGP 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1544 GPTESPASKGVTASLLAIPHTPESSSLPVALQTPTPGMVSGAMETtrvtvifAGSPNITvssrsPPAPRFPlmtKAVTVR 1623
Cdd:PRK12323  445 GGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAP-------APADDDP-----PPWEELP---PEFASP 509

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1624 GhgslPVRTTPPQPSLTASPSSRPVASPGAISRsPTSSGSHKAVLTPAVTKVISRTGVPQPTqaqSASSPSTPLTVAG-- 1701
Cdd:PRK12323  510 A----PAQPDAAPAGWVAESIPDPATADPDDAF-ETLAPAPAAAPAPRAAAATEPVVAPRPP---RASASGLPDMFDGdw 581

                         250
                  ....*....|...
gi 636526419 1702 -TAAEQVPVSPLA 1713
Cdd:PRK12323  582 pALAARLPVRGLA 594
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
1807-2028 3.45e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.91  E-value: 3.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1807 SLPLAKVGTSAPVATPGPKASVITTPLQPQATTLPAQTLSPVLPFTPAAMTQAhPPTHIAPPAAGTAPglllgatlPTSG 1886
Cdd:PRK07003  366 GAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAA-AATRAEAPPAAPAP--------PATA 436

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1887 vlpvAEGTASMVSVVPRKSTtgkvailskqvslptsmygSAEGGPTELTPATSHPLTPLVAEPEGAQAGTAlPVPTSYAL 1966
Cdd:PRK07003  437 ----DRGDDAADGDAPVPAK-------------------ANARASADSRCDERDAQPPADSGSASAPASDA-PPDAAFEP 492

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 636526419 1967 SRVSARTAPQDSMLVLLPQLAEAHGTSAGPHLAAEPVDEATTEPSGRSAPALSiVEGLAEAL 2028
Cdd:PRK07003  493 APRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEARPPTPAAAAPAAR-AGGAAAAL 553
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1541-1823 3.74e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 3.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1541 LPAGPtESPASKGVTASLLAIPHTPES-------------SSLP----VALQTPTPGMVSGAMETTRVTVIFAGSPNITV 1603
Cdd:PHA03247  205 VPSGP-GPAAPADLTAAALHLYGASETylqdepfverrvvISHPlrgdIAAPAPPPVVGEGADRAPETARGATGPPPPPE 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1604 SSRSPPAPRFPLMTKAVTVRGhgslpvrtTPPqpSLTASPSSRPVASPGAISRSPTSSGSHKaVLTPavtkvisrtgVPQ 1683
Cdd:PHA03247  284 AAAPNGAAAPPDGVWGAALAG--------APL--ALPAPPDPPPPAPAGDAEEEDDEDGAME-VVSP----------LPR 342

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1684 PTQAQSASSP-------STPLTVAG-TAAEQVPVS-PLATRSLEIVLSTE----KGEAGHSQPMGSPASPQPHPLPSAPP 1750
Cdd:PHA03247  343 PRQHYPLGFPkrrrptwTPPSSLEDlSAGRHHPKRaSLPTRKRRSARHAAtpfaRGPGGDDQTRPAAPVPASVPTPAPTP 422

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 636526419 1751 RPAqhttmatrSPALPPETPAAASLSTATDGLAATPfmSLESTRPSQLLSGLPPDTSLP--LAKVGTSAPVATPG 1823
Cdd:PHA03247  423 VPA--------SAPPPPATPLPSAEPGSDDGPAPPP--ERQPPAPATEPAPDDPDDATRkaLDALRERRPPEPPG 487
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 1668-2017 3.79e-03

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 42.53  E-value: 3.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1668 LTPAVTKVISRTGVPQPTQAQSASSPSTPLTVAGTAAEQVPVSPLATRSLEIVLSTEKGEAGHSQPMGSPASpqpHPLPS 1747
Cdd:COG3266     5 ETLSTLALALLLLSLSLVLGDLGLLLLLLLRALLSALELLLATGLRLLLLAGLLLLLIRLLSEAVDLGALAS---AALLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1748 APPRPAQHTTMATRSPALPPETPAAASLSTATDGLAATPFMSLESTRPSQLLSGLPPDTSLPLAKVGTSAPVATPGPKAS 1827
Cdd:COG3266    82 ALASLALLGILLLALLALLLDLLLLADLLRAAALLLLKLLLLLLTLLLLVLLLLLALLLALLLDLPLLTLLIVLPLLEEQ 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1828 VITTPLQPQATTLPAQTLSPVLPFTPAAMTQ-AHPPTHIAPPAAGTAPGLLLGATLPTSGVLPVAEGTASMVSVVPRKST 1906
Cdd:COG3266   162 LLLLALQDIQGTLQALGAVAALLGLRKAEEAlALRAGSAAADALALLLLLLASALGEAVAAAAELAALALLAAGAAEVLT 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1907 TGKVAILSkqvslptsMYGSAEGGPTELTPATSHPLTPLVAEPEGAQAGTALPVPTSYALSRVSARTAPqdsmlvllpql 1986
Cdd:COG3266   242 ARLVLLLL--------IIGSALKAPSQASSASAPATTSLGEQQEVSLPPAVAAQPAAAAAAQPSAVALP----------- 302

                         330       340       350
                  ....*....|....*....|....*....|.
gi 636526419 1987 aeahgtsagphlAAEPVDEATTEPSGRSAPA 2017
Cdd:COG3266   303 ------------AAPAAAAAAAAPAEAAAPQ 321
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1607-1851 4.23e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.56  E-value: 4.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1607 SPPAPRFPLMTKAVTVRGHGSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAVTkviSRTGVPQPTQ 1686
Cdd:PRK12323  372 AGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQ---ASARGPGGAP 448

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1687 AQSASSPSTPLTVAGTAAEQVPVSPLAtrsleivlstekgeAGHSQPMGSPAsPQPHPLPSA-PPRPAQHTTMATRSPAL 1765
Cdd:PRK12323  449 APAPAPAAAPAAAARPAAAGPRPVAAA--------------AAAAPARAAPA-AAPAPADDDpPPWEELPPEFASPAPAQ 513

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1766 PPETPAAASLSTATDGLAATPFMSLESTRPSQLLSGLPPDTSLPLAKVGTSAPVATPGPKASVITTPLQPQATTLPAQTL 1845
Cdd:PRK12323  514 PDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPALAARLPVRGL 593


                  ....*.
gi 636526419 1846 SPVLPF 1851
Cdd:PRK12323  594 AQQLAR 599
beta-trefoil_ABD_ABFB-like cd23265
Arabinose-binding domain (ABD), beta-trefoil fold, found in the ABFB family; The ABFB family ...
 1296-1383 5.58e-03

Arabinose-binding domain (ABD), beta-trefoil fold, found in the ABFB family; The ABFB family includes alpha-L-arabinofuranosidase B (ABF B)-like proteins and otogelin-like proteins. Alpha-L-arabinofuranosidase (EC 3.2.1.55), also called ABF, or non-reducing end alpha-L-arabinofuranosidase, or arabinofuranosidase, or arabinosidase, is involved in the degradation of arabinoxylan, a major component of plant hemicellulose. It can hydrolyze 1,5-, 1,3- and 1,2-alpha-linkages not only in L-arabinofuranosyl oligosaccharides, but also in polysaccharides containing terminal non-reducing L-arabinofuranoses in side chains, like L-arabinan, arabinogalactan and arabinoxylan. ABF belongs to the glycosyl hydrolase 54 family. Hungateiclostridium thermocellum anti-sigma-I factor RsgI5 shows high sequence similarity with ABF B. It negatively regulates SigI5 activity through direct interaction. The OTOG subfamily includes otogelin (OTOG) and otogelin-like protein (OTOGL). OTOG is a glycoprotein specific to acellular membranes of the inner ear. It may be required for the anchoring of otoconial membranes and cupula to the underlying neuroepithelia in the vestibule. OTOG may be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. OTOGL is a mucin glycoprotein that is a component of the tectorial membrane. It acts as a gel-forming mucin that forms high-molecular-weight complexes and is glycosylated through mucin-type O-glycosylation. Mutations in OTOG or OTOGL genes may cause hearing loss. Members of the ABFB family contain an ABD with a beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ABD binds two arabinose molecules in the beta and gamma subdomains.


Pssm-ID: 467807  Cd Length: 135  Bit Score: 39.57  E-value: 5.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1296 VVSLEAADRPNFFL-HVTANGSLELAKwqgrDTFQQHASFLLHRGTRQAGLVALESLAKPSSFLYVSGAVLALRLYEHTE 1374
Cdd:cd23265     5 PVRLRSASDPGYYIrHDGGSGSVTSDD----DDSAEDAFFRVVPGLAGEGTVSFESVDKPGYYLRHRGGELRLEKNDGSA 80


                  ....*....
gi 636526419 1375 VFRRGTLFR 1383
Cdd:cd23265    81 AFREDATFR 89
PPE COG5651
PPE-repeat protein [Function unknown];
1756-1975 6.33e-03

PPE-repeat protein [Function unknown];


Pssm-ID: 444372 [Multi-domain]  Cd Length: 385  Bit Score: 41.80  E-value: 6.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1756 TTMATRSPalPPETPA------AASLSTATDGLAATP----FMSLESTRPSQLLSGLPPDTSLPLAKVGTSAPVATPGPK 1825
Cdd:COG5651   158 SAAAVALT--PFTQPPptitnpGGLLGAQNAGSGNTSsnpgFANLGLTGLNQVGIGGLNSGSGPIGLNSGPGNTGFAGTG 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1826 ASViTTPLQPQATTLPAQTLSPVLPFTPAAMTQAHPPTHIAPPAAGTAPGLLLGATLPTSGVLPVAEGTASMVSVVPRKS 1905
Cdd:COG5651   236 AAA-GAAAAAAAAAAAAGAGASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAAATGLGLGAGG 314

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1906 TTGKVAILSKQVSLPTSMYGSAEGGPTELTPATSHPLTPLVAEPEGAQAGTALPVPTSYALSRVSARTAP 1975
Cdd:COG5651   315 AAGAAGATGAGAALGAGAAAAAAGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASGGGAA 384
Pacifastin_I pfam05375
Pacifastin inhibitor (LCMII); Structures of members of this family show that they are ...
 473-499 6.78e-03

Pacifastin inhibitor (LCMII); Structures of members of this family show that they are comprised of a triple-stranded antiparallel beta-sheet connected by three disulfide bridges, which defines this as a novel family of serine protease inhibitors.


Pssm-ID: 253170  Cd Length: 40  Bit Score: 36.60  E-value: 6.78e-03
                           10        20
                   ....*....|....*....|....*...
gi 636526419   473 PGSVVKEDCNTCTCT-SGKWECSTAVCP 499
Cdd:pfam05375    4 PGSTFKDDCNTCTCTaNGIAACTLKGCP 31
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1735-1902 7.49e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 7.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1735 GSPASPQPHP--LPSAPPRPAQHTTMATRSPALP----PETPAAASLSTATDGLAATPFMSLESTRPSQLLS-GLP---- 1803
Cdd:PHA03247  277 GPPPPPEAAApnGAAAPPDGVWGAALAGAPLALPappdPPPPAPAGDAEEEDDEDGAMEVVSPLPRPRQHYPlGFPkrrr 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1804 ----PDTSLPLAKVGTSAPVATPGPKASVITTPlqpQATTLPAQTLSPVLPFTPAAMTQAHPPTHIAPPAAGTAPglllg 1879
Cdd:PHA03247  357 ptwtPPSSLEDLSAGRHHPKRASLPTRKRRSAR---HAATPFARGPGGDDQTRPAAPVPASVPTPAPTPVPASAP----- 428

                         170       180
                  ....*....|....*....|...
gi 636526419 1880 atLPTSGVLPVAEGTASMVSVVP 1902
Cdd:PHA03247  429 --PPPATPLPSAEPGSDDGPAPP 449
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1842-2029 7.73e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.79  E-value: 7.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1842 AQTLSPVLPFTPAAMT-QAHPPTHIAPPAAGTAPGLLL-GATLPTSGVLPVAEGTASMVSVVPRKSTTGKVAILSKQVSL 1919
Cdd:PRK12323  354 TMTLLRMLAFRPGQSGgGAGPATAAAAPVAQPAPAAAApAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEAL 433

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1920 PTSMYGSAEGGPTELTPATSHPLTPLVAEPEGAQAGTALPVPTSYALSRVS--ARTAPQDSMlvlLPQLAEAHGTSAGPH 1997
Cdd:PRK12323  434 AAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAApaAAPAPADDD---PPPWEELPPEFASPA 510

                         170       180       190
                  ....*....|....*....|....*....|..
gi 636526419 1998 LAAEPVDEATTEPSGRSAPALSIVEGLAEALA 2029
Cdd:PRK12323  511 PAQPDAAPAGWVAESIPDPATADPDDAFETLA 542
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1726-2020 7.80e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.08  E-value: 7.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1726 GEAGHSQPMGSPA--SPQPHPLPSAPPRPAQHTTMATRSPALPPETPAAASLSTATDGLAATPFMSLESTRPSQLLSGLP 1803
Cdd:PHA03307   29 GDAADDLLSGSQGqlVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTP 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1804 PDTSLPLAKVGTSAPVATPGPKASVITTPLQPQATTLPAQTLSPVLPFTPAAMTQAHPPthiappaagTAPGLLLGATLP 1883
Cdd:PHA03307  109 PGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAA---------SSRQAALPLSSP 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1884 TSGVLPVAEGTASMVSVVPRKSTTGKVAILSKQVSLPTSMYGSAEGGPTELTP---ATSHPLTPLVAEPEGAQAGTALPV 1960
Cdd:PHA03307  180 EETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAgasSSDSSSSESSGCGWGPENECPLPR 259

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 636526419 1961 PTSYALSRVSARTAPQDSMLVlLPQLAEAHGTSAGPHLAAEPVDEATTEPSGRSAPALSI 2020
Cdd:PHA03307  260 PAPITLPTRIWEASGWNGPSS-RPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSS 318
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH