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Conserved domains on  [gi|645912881|ref|NP_001280116|]
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rRNA N6-adenosine-methyltransferase METTL5 [Homo sapiens]

Protein Classification

METTL5 family protein( domain architecture ID 10006292)

METTL5 family protein similar to Homo sapiens methyltransferase-like protein 5 that is a catalytic subunit of a heterodimer with TRMT112, which specifically methylates the 6th position of adenine in position 1832 of 18S rRNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
7-208 3.80e-75

Predicted RNA methylase [General function prediction only];


:

Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 224.78  E-value: 3.80e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912881   7 KELESRLQQVDGFEKPKLLLEQYPTRPHIAACMLYTIHnTYDDIENKVVADLGCGCGVLSIGTAMLGAGLCVGFDIDEDA 86
Cdd:COG2263    2 RELEIILEKLPGFSNPKVELEQYPTPAELAAELLHLAY-LRGDIEGKTVLDLGCGTGMLAIGAALLGAKKVVGVDIDPEA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912881  87 LEIFNRNAEEFElTNIDMVQCDVCllSNRMSKSFDTVIMNPPFGTkNNKGTDMAFLKTALEMARtAVYSLHKSSTREHVQ 166
Cdd:COG2263   81 LEIARENAERLG-VRVDFIRADVT--RIPLGGSVDTVVMNPPFGA-QRRHADRPFLEKALEIAA-VIYSIHNAGSLDFVE 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 645912881 167 KKAAEWKIKIDIIAELRYDLPASYKFHKKKSVDIEVDLIRFS 208
Cdd:COG2263  156 RFAADRGGEITHVFRAEFPIPRTFEFHRKRRRRIEVEVYRIE 197
 
Name Accession Description Interval E-value
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
7-208 3.80e-75

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 224.78  E-value: 3.80e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912881   7 KELESRLQQVDGFEKPKLLLEQYPTRPHIAACMLYTIHnTYDDIENKVVADLGCGCGVLSIGTAMLGAGLCVGFDIDEDA 86
Cdd:COG2263    2 RELEIILEKLPGFSNPKVELEQYPTPAELAAELLHLAY-LRGDIEGKTVLDLGCGTGMLAIGAALLGAKKVVGVDIDPEA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912881  87 LEIFNRNAEEFElTNIDMVQCDVCllSNRMSKSFDTVIMNPPFGTkNNKGTDMAFLKTALEMARtAVYSLHKSSTREHVQ 166
Cdd:COG2263   81 LEIARENAERLG-VRVDFIRADVT--RIPLGGSVDTVVMNPPFGA-QRRHADRPFLEKALEIAA-VIYSIHNAGSLDFVE 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 645912881 167 KKAAEWKIKIDIIAELRYDLPASYKFHKKKSVDIEVDLIRFS 208
Cdd:COG2263  156 RFAADRGGEITHVFRAEFPIPRTFEFHRKRRRRIEVEVYRIE 197
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 46-147 5.96e-14

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 66.85  E-value: 5.96e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912881   46 TYDDIENKVVADLGCGCGVLSIGTAMLGAGLCV-GFDIDEDALEIFNRNAEEFELTNIDMVQCDVclLSNRMSKSFDTVI 124
Cdd:pfam05175  26 HLPKDLSGKVLDLGCGAGVLGAALAKESPDAELtMVDINARALESARENLAANGLENGEVVASDV--YSGVEDGKFDLII 103

                          90       100
                  ....*....|....*....|....*
gi 645912881  125 MNPPF--GTKNNKGTDMAFLKTALE 147
Cdd:pfam05175 104 SNPPFhaGLATTYNVAQRFIADAKR 128
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 51-128 2.64e-11

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 60.95  E-value: 2.64e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 645912881  51 ENKVVADLGCGCGVLSIGTAMLGAGLCV-GFDIDEDALEIFNRNAEEFELTNIDMVQCDvcLLSNRMSKSFDTVIMNPP 128
Cdd:PRK09328 108 EPLRVLDLGTGSGAIALALAKERPDAEVtAVDISPEALAVARRNAKHGLGARVEFLQGD--WFEPLPGGRFDLIVSNPP 184
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 55-129 1.24e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 56.28  E-value: 1.24e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 645912881  55 VADLGCGCGVLSIGTAMLGAGLCVGFDIDEDALEIFNRNAEEFELTNIDMVQCDVCLLSNRMSKSFDTVIMNPPF 129
Cdd:cd02440    2 VLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPEADESFDVIISDPPL 76
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 57-129 9.96e-05

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 41.96  E-value: 9.96e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 645912881   57 DLGCGCGVLSIGTAMLGAGLCV-GFDIDEDALEIFNRNAEEFELT-NIDMVQCDvcLLSNRMSKSFDTVIMNPPF 129
Cdd:TIGR00536 120 DLGTGSGCIALALAYEFPNAEViAVDISPDALAVAEENAEKNQLEhRVEFIQSN--LFEPLAGQKIDIIVSNPPY 192
 
Name Accession Description Interval E-value
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
7-208 3.80e-75

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 224.78  E-value: 3.80e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912881   7 KELESRLQQVDGFEKPKLLLEQYPTRPHIAACMLYTIHnTYDDIENKVVADLGCGCGVLSIGTAMLGAGLCVGFDIDEDA 86
Cdd:COG2263    2 RELEIILEKLPGFSNPKVELEQYPTPAELAAELLHLAY-LRGDIEGKTVLDLGCGTGMLAIGAALLGAKKVVGVDIDPEA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912881  87 LEIFNRNAEEFElTNIDMVQCDVCllSNRMSKSFDTVIMNPPFGTkNNKGTDMAFLKTALEMARtAVYSLHKSSTREHVQ 166
Cdd:COG2263   81 LEIARENAERLG-VRVDFIRADVT--RIPLGGSVDTVVMNPPFGA-QRRHADRPFLEKALEIAA-VIYSIHNAGSLDFVE 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 645912881 167 KKAAEWKIKIDIIAELRYDLPASYKFHKKKSVDIEVDLIRFS 208
Cdd:COG2263  156 RFAADRGGEITHVFRAEFPIPRTFEFHRKRRRRIEVEVYRIE 197
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 55-148 6.15e-18

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 77.92  E-value: 6.15e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912881  55 VADLGCGCGVLSIGTAMLGAGLCV-GFDIDEDALEIFNRNAEEFELTNIDMVQCDVclLSNRMSKSFDTVIMNPPF--GT 131
Cdd:COG2813   53 VLDLGCGYGVIGLALAKRNPEARVtLVDVNARAVELARANAAANGLENVEVLWSDG--LSGVPDGSFDLILSNPPFhaGR 130

                         90
                 ....*....|....*..
gi 645912881 132 KNNKGTDMAFLKTALEM 148
Cdd:COG2813  131 AVDKEVAHALIADAARH 147
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 46-147 5.96e-14

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 66.85  E-value: 5.96e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912881   46 TYDDIENKVVADLGCGCGVLSIGTAMLGAGLCV-GFDIDEDALEIFNRNAEEFELTNIDMVQCDVclLSNRMSKSFDTVI 124
Cdd:pfam05175  26 HLPKDLSGKVLDLGCGAGVLGAALAKESPDAELtMVDINARALESARENLAANGLENGEVVASDV--YSGVEDGKFDLII 103

                          90       100
                  ....*....|....*....|....*
gi 645912881  125 MNPPF--GTKNNKGTDMAFLKTALE 147
Cdd:pfam05175 104 SNPPFhaGLATTYNVAQRFIADAKR 128
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 55-129 1.31e-12

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 64.40  E-value: 1.31e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 645912881  55 VADLGCGCGVLSIGTAMLGAGLCV-GFDIDEDALEIFNRNAEEFELTN-IDMVQCDVCLLSNRM-SKSFDTVIMNPPF 129
Cdd:COG4123   41 VLDLGTGTGVIALMLAQRSPGARItGVEIQPEAAELARRNVALNGLEDrITVIHGDLKEFAAELpPGSFDLVVSNPPY 118
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 33-179 9.40e-12

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 60.73  E-value: 9.40e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912881  33 PHIAACMLytihNTYDDIENKVVADLGCGCGVLSIGTAMLGAGlCVGFDIDEDALEIFNRNAEEFELTNIDMVQCDVCLL 112
Cdd:COG1041   12 PRLARALV----NLAGAKEGDTVLDPFCGTGTILIEAGLLGRR-VIGSDIDPKMVEGARENLEHYGYEDADVIRGDARDL 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 645912881 113 SNRmSKSFDTVIMNPPFG--TKNNKGTDMAFLKTALEMART-------AVYSLHKSSTREHvqkKAAEWKIKIDII 179
Cdd:COG1041   87 PLA-DESVDAIVTDPPYGrsSKISGEELLELYEKALEEAARvlkpggrVVIVTPRDIDELL---EEAGFKVLERHE 158
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 51-128 2.64e-11

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 60.95  E-value: 2.64e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 645912881  51 ENKVVADLGCGCGVLSIGTAMLGAGLCV-GFDIDEDALEIFNRNAEEFELTNIDMVQCDvcLLSNRMSKSFDTVIMNPP 128
Cdd:PRK09328 108 EPLRVLDLGTGSGAIALALAKERPDAEVtAVDISPEALAVARRNAKHGLGARVEFLQGD--WFEPLPGGRFDLIVSNPP 184
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
49-95 5.32e-11

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 60.19  E-value: 5.32e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 645912881  49 DIENKVVADLGCGCGVLSIGTAMLGAGLCVGFDIDEDALEIFNRNAE 95
Cdd:COG2264  146 LKPGKTVLDVGCGSGILAIAAAKLGAKRVLAVDIDPVAVEAARENAE 192
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
49-95 6.52e-11

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 59.78  E-value: 6.52e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 645912881  49 DIENKVVADLGCGCGVLSIGTAMLGAGLCVGFDIDEDALEIFNRNAE 95
Cdd:PRK00517 117 VLPGKTVLDVGCGSGILAIAAAKLGAKKVLAVDIDPQAVEAARENAE 163
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 55-129 1.24e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 56.28  E-value: 1.24e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 645912881  55 VADLGCGCGVLSIGTAMLGAGLCVGFDIDEDALEIFNRNAEEFELTNIDMVQCDVCLLSNRMSKSFDTVIMNPPF 129
Cdd:cd02440    2 VLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPEADESFDVIISDPPL 76
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 55-150 2.59e-10

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 55.26  E-value: 2.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912881   55 VADLGCGCGVLSIGTAMLGAGLCVGFDIDEDALEIFNRNAEEFELtNIDMVQCDVCLLSNRmSKSFDTVIMNPPFGTKNN 134
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGL-NVEFVQGDAEDLPFP-DGSFDLVVSSGVLHHLPD 78

                          90
                  ....*....|....*.
gi 645912881  135 KGTDmAFLKtalEMAR 150
Cdd:pfam13649  79 PDLE-AALR---EIAR 90
PRK14968 PRK14968
putative methyltransferase; Provisional
 49-185 5.42e-10

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 56.45  E-value: 5.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912881  49 DIENKVVADLGCGCGVLSIGTAMLGAGLcVGFDIDEDALEIFNRNAEEFELTN--IDMVQCDvcLLSNRMSKSFDTVIMN 126
Cdd:PRK14968  21 DKKGDRVLEVGTGSGIVAIVAAKNGKKV-VGVDINPYAVECAKCNAKLNNIRNngVEVIRSD--LFEPFRGDKFDVILFN 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912881 127 PPF-----GTKNNKGTDMA-------------FLKTA---LEMARTaVYSLHKSST-REHVQKKAAEWKIKIDIIAELRY 184
Cdd:PRK14968  98 PPYlpteeEEEWDDWLNYAlsggkdgrevidrFLDEVgryLKPGGR-ILLLQSSLTgEDEVLEYLEKLGFEAEVVAEEKF 176


                 .
gi 645912881 185 D 185
Cdd:PRK14968 177 P 177
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 55-126 7.55e-10

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 57.28  E-value: 7.55e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 645912881   55 VADLGCGCGVLSIGTAMLGAGLCVGFDIDEDALEIFNRNAEEFELTNIDMVQcdvcLLSNRMSKSFDTVIMN 126
Cdd:pfam06325 165 VLDVGCGSGILAIAALKLGAKKVVGVDIDPVAVRAAKENAELNGVEARLEVY----LPGDLPKEKADVVVAN 232
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 51-126 5.03e-09

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 52.33  E-value: 5.03e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 645912881  51 ENKVVADLGCGCGVLSIgtAMLGAGLCV-GFDIDEDALEIFNRNAEEFeltNIDMVQCDVCLLSNRmSKSFDTVIMN 126
Cdd:COG2227   24 AGGRVLDVGCGTGRLAL--ALARRGADVtGVDISPEALEIARERAAEL---NVDFVQGDLEDLPLE-DGSFDLVICS 94
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 48-128 9.68e-09

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 54.00  E-value: 9.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912881  48 DDIENKVVADLGCGCGVLSIGTAMLGAGL-CVGFDIDEDALEIFNRNAEEFELTN-IDMVQCDvcLLSN-RMSKSFDTVI 124
Cdd:COG2890  109 PAGAPPRVLDLGTGSGAIALALAKERPDArVTAVDISPDALAVARRNAERLGLEDrVRFLQGD--LFEPlPGDGRFDLIV 186


                 ....
gi 645912881 125 MNPP 128
Cdd:COG2890  187 SNPP 190
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 55-126 2.02e-08

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 52.23  E-value: 2.02e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 645912881  55 VADLGCGCGVLSIGTAMLGAGLCVGFDIDEDALEIFNRNAEEFELTNIDMVQCDVCLLSNRMSKSFDTVIMN 126
Cdd:COG0500   30 VLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALARARAAKAGLGNVEFLVADLAELDPLPAESFDLVVAF 101
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 51-126 1.02e-07

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 49.22  E-value: 1.02e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 645912881  51 ENKVVADLGCGCGVLSIGTAMLGAgLCVGFDIDEDALEIFNRNAEEFELtNIDMVQCDVCLLSNRmSKSFDTVIMN 126
Cdd:COG2226   22 PGARVLDLGCGTGRLALALAERGA-RVTGVDISPEMLELARERAAEAGL-NVEFVVGDAEDLPFP-DGSFDLVISS 94
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 51-126 6.54e-07

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 47.03  E-value: 6.54e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 645912881   51 ENKVVADLGCGCGVLSIGTAMLGAGLC--VGFDIDEDALEIFNRNAEEFELTNIDMVQCDVCLLSNRMS-KSFDTVIMN 126
Cdd:pfam13847   3 KGMRVLDLGCGTGHLSFELAEELGPNAevVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEELPELLEdDKFDVVISN 81
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 30-130 6.63e-07

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 47.74  E-value: 6.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912881   30 PTRPHIAACMLYTIHNTYDDienkVVADLGCGCGVLSIGTAMLGA------------GLCVGFDIDEDALEIFNRNAEEF 97
Cdd:pfam01170  11 PLKETLAAAMVNLAGWKPGD----PLLDPMCGSGTILIEAALMGAniapgkfdarvrAPLYGSDIDRRMVQGARLNAENA 86

                          90       100       110
                  ....*....|....*....|....*....|....
gi 645912881   98 ELTN-IDMVQCDVCLLSnRMSKSFDTVIMNPPFG 130
Cdd:pfam01170  87 GVGDlIEFVQADAADLP-LLEGSVDVIVTNPPYG 119
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 48-128 1.61e-06

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 47.48  E-value: 1.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912881  48 DDIENKVVADLGCGCGVLSIGTAmLGAGLCVGFDIDEDALEIFNRNAEEFELTNIDMVQCDVCLLSNRMSKS--FDTVIM 125
Cdd:COG2265  230 DLTGGERVLDLYCGVGTFALPLA-RRAKKVIGVEIVPEAVEDARENARLNGLKNVEFVAGDLEEVLPELLWGgrPDVVVL 308


                 ...
gi 645912881 126 NPP 128
Cdd:COG2265  309 DPP 311
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 47-95 1.10e-05

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 44.49  E-value: 1.10e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 645912881  47 YDDIENKVVADLGCGCGVLSIGTAMLGAGLCVGFDIDEDALEIFNRNAE 95
Cdd:COG3897   66 HPEVAGKRVLELGCGLGLVGIAAAKAGAADVTATDYDPEALAALRLNAA 114
RlmL COG0116
23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA ...
 78-130 4.55e-05

23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA G2445 N2-methylase RlmL is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 439886 [Multi-domain]  Cd Length: 369  Bit Score: 43.17  E-value: 4.55e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 645912881  78 VGFDIDEDALEIFNRNAEEFELTN-IDMVQCDVCLLsnRMSKSFDTVIMNPPFG 130
Cdd:COG0116  254 FGSDIDPRAIEAARENAERAGVADlIEFEQADFRDL--EPPAEPGLIITNPPYG 305
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 57-126 5.66e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 40.81  E-value: 5.66e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 645912881   57 DLGCGCGVLSIGTAMLGAGL-CVGFDIDEDALEIFNRNAEEFELTNIDMVQCDVCLLSNRMSKSFDTVIMN 126
Cdd:pfam08242   2 EIGCGTGTLLRALLEALPGLeYTGLDISPAALEAARERLAALGLLNAVRVELFQLDLGELDPGSFDVVVAS 72
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 57-129 9.96e-05

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 41.96  E-value: 9.96e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 645912881   57 DLGCGCGVLSIGTAMLGAGLCV-GFDIDEDALEIFNRNAEEFELT-NIDMVQCDvcLLSNRMSKSFDTVIMNPPF 129
Cdd:TIGR00536 120 DLGTGSGCIALALAYEFPNAEViAVDISPDALAVAEENAEKNQLEhRVEFIQSN--LFEPLAGQKIDIIVSNPPY 192
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
55-126 1.34e-04

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 41.14  E-value: 1.34e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 645912881  55 VADLGCGCGVLsiGTAMLGAGLCV-GFDIDEDALEIFNRNAEEFELTNIDMVQCDVcllsnrMSKSFDTVIMN 126
Cdd:COG4976   50 VLDLGCGTGLL--GEALRPRGYRLtGVDLSEEMLAKAREKGVYDRLLVADLADLAE------PDGRFDLIVAA 114
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
51-109 1.69e-04

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 41.18  E-value: 1.69e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912881  51 ENKVVADLGCGCGVLSIGTAMLGAGLCVGFDIDEDALEIFNRNAEEFELT-NIDMVQCDV 109
Cdd:COG4076   35 PGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSdRITVINADA 94
PRK14967 PRK14967
putative methyltransferase; Provisional
 55-129 2.20e-04

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 40.81  E-value: 2.20e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 645912881  55 VADLGCGCGVLSIGTAMLGAGLCVGFDIDEDALEIFNRNAEEFELTnIDMVQCDvcLLSNRMSKSFDTVIMNPPF 129
Cdd:PRK14967  40 VLDLCTGSGALAVAAAAAGAGSVTAVDISRRAVRSARLNALLAGVD-VDVRRGD--WARAVEFRPFDVVVSNPPY 111
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 54-106 2.21e-04

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 41.31  E-value: 2.21e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 645912881  54 VVADLGCGCGVLSIGTAMLGAGLCV-GFDIDEDALEIFNRNAEEFELTNIDMVQ 106
Cdd:COG2242  250 VLWDIGAGSGSVSIEAARLAPGGRVyAIERDPERAALIRANARRFGVPNVEVVE 303
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 49-130 3.60e-04

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 39.68  E-value: 3.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912881  49 DIENKVVADLGCGCGVLSIGTAMLGAGLCVGFDIDEDALEIFNRNAEEFELT-NIDMVQCDVC-LLSNRMSKSFDTVIMN 126
Cdd:COG0742   39 DIEGARVLDLFAGSGALGLEALSRGAASVVFVEKDRKAAAVIRKNLEKLGLEdRARVIRGDALrFLKRLAGEPFDLVFLD 118


                 ....
gi 645912881 127 PPFG 130
Cdd:COG0742  119 PPYA 122
cbiT PRK00377
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional
 54-121 8.91e-04

cobalt-precorrin-6Y C(15)-methyltransferase; Provisional


Pssm-ID: 234740  Cd Length: 198  Bit Score: 39.01  E-value: 8.91e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 645912881  54 VVADLGCGCGVLSIGTAML-GAGLCV-GFDIDEDALEIFNRNAEEF-ELTNIDMVQCDVCLLSNRMSKSFD 121
Cdd:PRK00377  43 MILDIGCGTGSVTVEASLLvGETGKVyAVDKDEKAINLTRRNAEKFgVLNNIVLIKGEAPEILFTINEKFD 113
rsmC PRK09489
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;
55-158 9.10e-04

16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;


Pssm-ID: 181902 [Multi-domain]  Cd Length: 342  Bit Score: 39.15  E-value: 9.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912881  55 VADLGCGCGVLSigtAMLGAG-------LCvgfDIDEDALEIFNRNAEEFELTNiDMVQCDVclLSNrMSKSFDTVIMNP 127
Cdd:PRK09489 200 VLDVGCGAGVLS---AVLARHspkirltLS---DVSAAALESSRATLAANGLEG-EVFASNV--FSD-IKGRFDMIISNP 269

                         90       100       110
                 ....*....|....*....|....*....|.
gi 645912881 128 PFgtknNKGTDMAfLKTALEMARTAVYSLHK 158
Cdd:PRK09489 270 PF----HDGIQTS-LDAAQTLIRGAVRHLNS 295
TRM1 COG1867
tRNA G26 N,N-dimethylase Trm1 [Translation, ribosomal structure and biogenesis]; tRNA G26 N, ...
 81-131 4.92e-03

tRNA G26 N,N-dimethylase Trm1 [Translation, ribosomal structure and biogenesis]; tRNA G26 N,N-dimethylase Trm1 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441472  Cd Length: 383  Bit Score: 37.16  E-value: 4.92e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 645912881  81 DIDEDALEIFNRNAEEFELTNIDMVQCDVCLLSNRMSKSFDTVIMNpPFGT 131
Cdd:COG1867   87 DIDPEAVELIRENLELNGLEDVEVYNRDANALLHELGRRFDVVDLD-PFGS 136
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
55-126 5.07e-03

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 35.18  E-value: 5.07e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 645912881  55 VADLGCGCGVLsigTAML----GAGLCVGFDIDEDALEIFNRNaeefeLTNIDMVQCDVCLLsnRMSKSFDTVIMN 126
Cdd:COG4106    5 VLDLGCGTGRL---TALLaerfPGARVTGVDLSPEMLARARAR-----LPNVRFVVADLRDL--DPPEPFDLVVSN 70
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 55-124 6.78e-03

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 35.68  E-value: 6.78e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 645912881  55 VADLGCGCGVLSIGTAMLGAGLCVGFDIDEDALEIFNRNAEEFELTN-IDMVQCDVCLLsnRMSKSFDTVI 124
Cdd:COG2230   55 VLDIGCGWGGLALYLARRYGVRVTGVTLSPEQLEYARERAAEAGLADrVEVRLADYRDL--PADGQFDAIV 123
rlmL PRK11783
bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2)) ...
 79-130 8.75e-03

bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL;


Pssm-ID: 236981 [Multi-domain]  Cd Length: 702  Bit Score: 36.70  E-value: 8.75e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 645912881  79 GFDIDEDALEIFNRNAEEFELTN-IDMVQCDVCLLSNRMSK-SFDTVIMNPPFG 130
Cdd:PRK11783 261 GSDIDPRVIQAARKNARRAGVAElITFEVKDVADLKNPLPKgPTGLVISNPPYG 314
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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