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Conserved domains on  [gi|645912966|ref|NP_001280134|]
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major vault protein isoform 3 [Homo sapiens]

Protein Classification

major vault protein( domain architecture ID 1009019)

major vault protein (MVP) is required for normal vault structure

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00491 super family cl36570
major vault protein; Provisional
 4-784 0e+00

major vault protein; Provisional


The actual alignment was detected with superfamily member PTZ00491:

Pssm-ID: 240439 [Multi-domain]  Cd Length: 850  Bit Score: 1028.42  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966   4 EEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPMRMVTVPPRHYCTVANPVSRDAQGLVLFDVTGQVRL 83
Cdd:PTZ00491   3 TESVIRLKPYEYIHVLDNNTNVTRLIVGPQTFTRQDHERVLHPPQPMVVVPPRHYCIVENPHVRDPDGSPVKDAYGQVKV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966  84 RHADLEIRLAQDPFPLYPGEVLEKDITPLQVVLPNTALHLKALLDFEDKDGDKVVAGDEWLFEGPGTYIPRKEVEVVEII 163
Cdd:PTZ00491  83 RHGEREIRFSQDPFPLYPGEKLVTQVEPLKVLPANEALRVRALRDFTVEDGVRRVAGEEWLFKGPGTYYPRVEERIVEEV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966 164 QATIIRQNQALRLRARKECWDRDGKERVTGEEWLVTTVGAYLPAVFEEVLDLVDAVILTEKTALHLRARRNFRD-FRGVS 242
Cdd:PTZ00491 163 KAVLIKPNQALKLRALETFTDRDGVPRVAGEEWLVRTPGAYLPGVFEEVVGVVKGIVLSDKEALHLRALRTFTDvYGGIA 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966 243 RRTGEEWLVTVQDTEAHVPDVHEEVLGVVPITTLGPHNYCVILDPVGPDGKNQLGQKRVVKGEKSFFLQPGEQLE-QGIQ 321
Cdd:PTZ00491 243 RKAGEEWLVTHEDCPTHIPDVYEKLVATVNATHLSARQYCVILNPVGDDGHNRFGAKELRKGECSFFLQPGESLEgDGIQ 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966 322 DVYVLSEQQGLLLRAlqpLEEGEDEEKVSHQAGDHWLIRGPLEYVPSAKVEVVEERQAIPLDENEGIYVQDVKTGKVRAV 401
Cdd:PTZ00491 323 DAYVLGEDEALLLRA---LETFTDEDGVEREPGDRWLVHGPCEYIPPVLVEVVERRRRIPLDENEGIYVRNITTGEVRAV 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966 402 IGSTYMLTQDEVLWEKELPPGVEELLNKGQDPLAD-------RGEKDTAKSLQPLAPRNKTRVVSYRVPHNAAVQVYDYR 474
Cdd:PTZ00491 400 HGKPYMLGAHEELWEKPLPPNVEELLAQPRSSMAYsersgqaSGKVPYEENPGFESHRDKHRVVTYKVPHNAAVQLYDYK 479

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966 475 EKRAR------------------------------------------------------------------HFEVnDRKD 488
Cdd:PTZ00491 480 TKKSRvvfgpdlvmlepdeeftvlslsggkpkvpnqihslhlflgpdfmtdvihvetsdharlalqlsynwYFDV-TDGN 558

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966 489 PQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRTAVFGF--ETSEakgpdgmalprPRDQAVFPQNG 566
Cdd:PTZ00491 559 PEDAQKCFSVPDFVGDACKTIASRVRAAVASEPFDEFHKNSAKIIRQAVFGSndETGE-----------VRDSLRFPANN 627

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966 567 LVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEAL 646
Cdd:PTZ00491 628 LVITNVDVQSVEPVDERTRDSLQKSVQLAIEITTKSQEAAARHQAELLEQEARGRLERQKMHDKAKAEEQRTKLLELQAE 707

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966 647 SMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEV 726
Cdd:PTZ00491 708 SAAVESSGQSRAEALAEAEARLIEAEAEVEQAELRAKALRIEAEAELEKLRKRQELELEYEQAQNELEIAKAKELADIEA 787

                        810       820       830       840       850
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 645912966 727 KKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSTPINLFNTAFGLLG 784
Cdd:PTZ00491 788 TKFERIVEALGRETLIAIARAGPELQAKLLGGLGLKGYLVTDGKSPINLFNTANGLIG 845
 
Name Accession Description Interval E-value
PTZ00491 PTZ00491
major vault protein; Provisional
 4-784 0e+00

major vault protein; Provisional


Pssm-ID: 240439 [Multi-domain]  Cd Length: 850  Bit Score: 1028.42  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966   4 EEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPMRMVTVPPRHYCTVANPVSRDAQGLVLFDVTGQVRL 83
Cdd:PTZ00491   3 TESVIRLKPYEYIHVLDNNTNVTRLIVGPQTFTRQDHERVLHPPQPMVVVPPRHYCIVENPHVRDPDGSPVKDAYGQVKV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966  84 RHADLEIRLAQDPFPLYPGEVLEKDITPLQVVLPNTALHLKALLDFEDKDGDKVVAGDEWLFEGPGTYIPRKEVEVVEII 163
Cdd:PTZ00491  83 RHGEREIRFSQDPFPLYPGEKLVTQVEPLKVLPANEALRVRALRDFTVEDGVRRVAGEEWLFKGPGTYYPRVEERIVEEV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966 164 QATIIRQNQALRLRARKECWDRDGKERVTGEEWLVTTVGAYLPAVFEEVLDLVDAVILTEKTALHLRARRNFRD-FRGVS 242
Cdd:PTZ00491 163 KAVLIKPNQALKLRALETFTDRDGVPRVAGEEWLVRTPGAYLPGVFEEVVGVVKGIVLSDKEALHLRALRTFTDvYGGIA 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966 243 RRTGEEWLVTVQDTEAHVPDVHEEVLGVVPITTLGPHNYCVILDPVGPDGKNQLGQKRVVKGEKSFFLQPGEQLE-QGIQ 321
Cdd:PTZ00491 243 RKAGEEWLVTHEDCPTHIPDVYEKLVATVNATHLSARQYCVILNPVGDDGHNRFGAKELRKGECSFFLQPGESLEgDGIQ 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966 322 DVYVLSEQQGLLLRAlqpLEEGEDEEKVSHQAGDHWLIRGPLEYVPSAKVEVVEERQAIPLDENEGIYVQDVKTGKVRAV 401
Cdd:PTZ00491 323 DAYVLGEDEALLLRA---LETFTDEDGVEREPGDRWLVHGPCEYIPPVLVEVVERRRRIPLDENEGIYVRNITTGEVRAV 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966 402 IGSTYMLTQDEVLWEKELPPGVEELLNKGQDPLAD-------RGEKDTAKSLQPLAPRNKTRVVSYRVPHNAAVQVYDYR 474
Cdd:PTZ00491 400 HGKPYMLGAHEELWEKPLPPNVEELLAQPRSSMAYsersgqaSGKVPYEENPGFESHRDKHRVVTYKVPHNAAVQLYDYK 479

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966 475 EKRAR------------------------------------------------------------------HFEVnDRKD 488
Cdd:PTZ00491 480 TKKSRvvfgpdlvmlepdeeftvlslsggkpkvpnqihslhlflgpdfmtdvihvetsdharlalqlsynwYFDV-TDGN 558

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966 489 PQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRTAVFGF--ETSEakgpdgmalprPRDQAVFPQNG 566
Cdd:PTZ00491 559 PEDAQKCFSVPDFVGDACKTIASRVRAAVASEPFDEFHKNSAKIIRQAVFGSndETGE-----------VRDSLRFPANN 627

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966 567 LVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEAL 646
Cdd:PTZ00491 628 LVITNVDVQSVEPVDERTRDSLQKSVQLAIEITTKSQEAAARHQAELLEQEARGRLERQKMHDKAKAEEQRTKLLELQAE 707

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966 647 SMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEV 726
Cdd:PTZ00491 708 SAAVESSGQSRAEALAEAEARLIEAEAEVEQAELRAKALRIEAEAELEKLRKRQELELEYEQAQNELEIAKAKELADIEA 787

                        810       820       830       840       850
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 645912966 727 KKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSTPINLFNTAFGLLG 784
Cdd:PTZ00491 788 TKFERIVEALGRETLIAIARAGPELQAKLLGGLGLKGYLVTDGKSPINLFNTANGLIG 845
MVP_shoulder cd08825
Shoulder domain of the major vault protein; The major vault protein is the major polypeptide ...
 480-604 3.41e-54

Shoulder domain of the major vault protein; The major vault protein is the major polypeptide component of a large cellular ribonuclear protein complex found in the cytoplasm of eukaryotic cells. Its shoulder domain appears to be a homolog of the SPFH core domain. Vault proteins may be involved in detoxification processes, and have been associated with the multi-drug resistance (MDR) phenotype in malignancies. Presumably they play a role in transport processes.


Pssm-ID: 259807  Cd Length: 151  Bit Score: 184.35  E-value: 3.41e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966 480 HFEVNDRKdPQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRTAVFGFetsEAKGPDgmalprpRDQ 559
Cdd:cd08825   38 HFDVDDKK-PEEAAKLFSVPDFIGDACKAIASRIRGAVASVTFDDFHKNSARIIRSAVFGD---DEKGEV-------RDE 106

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 645912966 560 AVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQE 604
Cdd:cd08825  107 LRFPANNLVITNVDIQSVEPVDQRTRDSLQKSVQLAIEITTNSQE 151
MVP_shoulder pfam11978
Shoulder domain; This domain is found in the Major Vault Protein and has been called the ...
 480-581 1.79e-38

Shoulder domain; This domain is found in the Major Vault Protein and has been called the shoulder domain. This family includes two bacterial proteins Swiss:A6FXE2 and Swiss:A1ZGE7. This suggests that some bacteria may possess vault particles.


Pssm-ID: 463418  Cd Length: 118  Bit Score: 138.92  E-value: 1.79e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966  480 HFEVnDRKDPQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRTAVFGFetsEAKGpdgmalpRPRDQ 559
Cdd:pfam11978  28 HFDV-DDGDPEDAAKLFSVPDFVGDACKAIASRIRGAVASVTFDDFHKNSAKIIRRAVFGV---DENG-------EVRDS 96

                          90       100
                  ....*....|....*....|..
gi 645912966  560 AVFPQNGLVVSSVDVQSVEPVD 581
Cdd:pfam11978  97 LLFPENNLVITSVDVQSVEPVD 118
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 587-718 1.59e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 42.23  E-value: 1.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966 587 ALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKAEAESRAEA 666
Cdd:COG1196  442 EALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRG 521

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 645912966 667 arIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKA 718
Cdd:COG1196  522 --LAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKA 571
 
Name Accession Description Interval E-value
PTZ00491 PTZ00491
major vault protein; Provisional
 4-784 0e+00

major vault protein; Provisional


Pssm-ID: 240439 [Multi-domain]  Cd Length: 850  Bit Score: 1028.42  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966   4 EEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPMRMVTVPPRHYCTVANPVSRDAQGLVLFDVTGQVRL 83
Cdd:PTZ00491   3 TESVIRLKPYEYIHVLDNNTNVTRLIVGPQTFTRQDHERVLHPPQPMVVVPPRHYCIVENPHVRDPDGSPVKDAYGQVKV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966  84 RHADLEIRLAQDPFPLYPGEVLEKDITPLQVVLPNTALHLKALLDFEDKDGDKVVAGDEWLFEGPGTYIPRKEVEVVEII 163
Cdd:PTZ00491  83 RHGEREIRFSQDPFPLYPGEKLVTQVEPLKVLPANEALRVRALRDFTVEDGVRRVAGEEWLFKGPGTYYPRVEERIVEEV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966 164 QATIIRQNQALRLRARKECWDRDGKERVTGEEWLVTTVGAYLPAVFEEVLDLVDAVILTEKTALHLRARRNFRD-FRGVS 242
Cdd:PTZ00491 163 KAVLIKPNQALKLRALETFTDRDGVPRVAGEEWLVRTPGAYLPGVFEEVVGVVKGIVLSDKEALHLRALRTFTDvYGGIA 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966 243 RRTGEEWLVTVQDTEAHVPDVHEEVLGVVPITTLGPHNYCVILDPVGPDGKNQLGQKRVVKGEKSFFLQPGEQLE-QGIQ 321
Cdd:PTZ00491 243 RKAGEEWLVTHEDCPTHIPDVYEKLVATVNATHLSARQYCVILNPVGDDGHNRFGAKELRKGECSFFLQPGESLEgDGIQ 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966 322 DVYVLSEQQGLLLRAlqpLEEGEDEEKVSHQAGDHWLIRGPLEYVPSAKVEVVEERQAIPLDENEGIYVQDVKTGKVRAV 401
Cdd:PTZ00491 323 DAYVLGEDEALLLRA---LETFTDEDGVEREPGDRWLVHGPCEYIPPVLVEVVERRRRIPLDENEGIYVRNITTGEVRAV 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966 402 IGSTYMLTQDEVLWEKELPPGVEELLNKGQDPLAD-------RGEKDTAKSLQPLAPRNKTRVVSYRVPHNAAVQVYDYR 474
Cdd:PTZ00491 400 HGKPYMLGAHEELWEKPLPPNVEELLAQPRSSMAYsersgqaSGKVPYEENPGFESHRDKHRVVTYKVPHNAAVQLYDYK 479

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966 475 EKRAR------------------------------------------------------------------HFEVnDRKD 488
Cdd:PTZ00491 480 TKKSRvvfgpdlvmlepdeeftvlslsggkpkvpnqihslhlflgpdfmtdvihvetsdharlalqlsynwYFDV-TDGN 558

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966 489 PQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRTAVFGF--ETSEakgpdgmalprPRDQAVFPQNG 566
Cdd:PTZ00491 559 PEDAQKCFSVPDFVGDACKTIASRVRAAVASEPFDEFHKNSAKIIRQAVFGSndETGE-----------VRDSLRFPANN 627

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966 567 LVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEAL 646
Cdd:PTZ00491 628 LVITNVDVQSVEPVDERTRDSLQKSVQLAIEITTKSQEAAARHQAELLEQEARGRLERQKMHDKAKAEEQRTKLLELQAE 707

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966 647 SMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEV 726
Cdd:PTZ00491 708 SAAVESSGQSRAEALAEAEARLIEAEAEVEQAELRAKALRIEAEAELEKLRKRQELELEYEQAQNELEIAKAKELADIEA 787

                        810       820       830       840       850
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 645912966 727 KKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSTPINLFNTAFGLLG 784
Cdd:PTZ00491 788 TKFERIVEALGRETLIAIARAGPELQAKLLGGLGLKGYLVTDGKSPINLFNTANGLIG 845
MVP_shoulder cd08825
Shoulder domain of the major vault protein; The major vault protein is the major polypeptide ...
 480-604 3.41e-54

Shoulder domain of the major vault protein; The major vault protein is the major polypeptide component of a large cellular ribonuclear protein complex found in the cytoplasm of eukaryotic cells. Its shoulder domain appears to be a homolog of the SPFH core domain. Vault proteins may be involved in detoxification processes, and have been associated with the multi-drug resistance (MDR) phenotype in malignancies. Presumably they play a role in transport processes.


Pssm-ID: 259807  Cd Length: 151  Bit Score: 184.35  E-value: 3.41e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966 480 HFEVNDRKdPQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRTAVFGFetsEAKGPDgmalprpRDQ 559
Cdd:cd08825   38 HFDVDDKK-PEEAAKLFSVPDFIGDACKAIASRIRGAVASVTFDDFHKNSARIIRSAVFGD---DEKGEV-------RDE 106

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 645912966 560 AVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQE 604
Cdd:cd08825  107 LRFPANNLVITNVDIQSVEPVDQRTRDSLQKSVQLAIEITTNSQE 151
MVP_shoulder pfam11978
Shoulder domain; This domain is found in the Major Vault Protein and has been called the ...
 480-581 1.79e-38

Shoulder domain; This domain is found in the Major Vault Protein and has been called the shoulder domain. This family includes two bacterial proteins Swiss:A6FXE2 and Swiss:A1ZGE7. This suggests that some bacteria may possess vault particles.


Pssm-ID: 463418  Cd Length: 118  Bit Score: 138.92  E-value: 1.79e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966  480 HFEVnDRKDPQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRTAVFGFetsEAKGpdgmalpRPRDQ 559
Cdd:pfam11978  28 HFDV-DDGDPEDAAKLFSVPDFVGDACKAIASRIRGAVASVTFDDFHKNSAKIIRRAVFGV---DENG-------EVRDS 96

                          90       100
                  ....*....|....*....|..
gi 645912966  560 AVFPQNGLVVSSVDVQSVEPVD 581
Cdd:pfam11978  97 LLFPENNLVITSVDVQSVEPVD 118
Vault_2 pfam17794
Major Vault Protein repeat domain; This short domain is found repeated numerous times in the ...
 50-109 1.23e-29

Major Vault Protein repeat domain; This short domain is found repeated numerous times in the Major Vault Protein. This entry is related to pfam01505.


Pssm-ID: 407666 [Multi-domain]  Cd Length: 60  Bit Score: 111.79  E-value: 1.23e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966   50 MVTVPPRHYCTVANPVSRDAQGLVLFDVTGQVRLRHADLEIRLAQDPFPLYPGEVLEKDI 109
Cdd:pfam17794   1 MITLPPRSYCVVANPVSRDGKGSPVLDQHGQVRLVHGDKEIRLAQDPFPLYPGEKLEGDI 60
Vault_4 pfam17796
Major Vault Protein repeat domain;
379-439 9.99e-24

Major Vault Protein repeat domain;


Pssm-ID: 407668 [Multi-domain]  Cd Length: 61  Bit Score: 94.98  E-value: 9.99e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 645912966  379 AIPLDENEGIYVQDVKTGKVRAVIGSTYMLTQDEVLWEKELPPGVEELLNKGQDPLADRGE 439
Cdd:pfam17796   1 AIPLDENEGIYVRNIRTGEVRVVTGQTYMLTESEELWEKELPPGVEVLLAEARDPLAGRDS 61
Vault pfam01505
Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ...
 113-153 1.04e-15

Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ribonucleoprotein particle of approximately 13 mDa of unknown function. This family corresponds to a repeated domain found in the amino terminal half of the major vault protein.


Pssm-ID: 460235 [Multi-domain]  Cd Length: 41  Bit Score: 71.31  E-value: 1.04e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 645912966  113 QVVLPNTALHLKALLDFEDKDGDKVVAGDEWLFEGPGTYIP 153
Cdd:pfam01505   1 YVLSENEALRLRALEDFTDRDGVERKAGEEWLVRGPGTYIP 41
Vault pfam01505
Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ...
 166-206 2.53e-14

Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ribonucleoprotein particle of approximately 13 mDa of unknown function. This family corresponds to a repeated domain found in the amino terminal half of the major vault protein.


Pssm-ID: 460235 [Multi-domain]  Cd Length: 41  Bit Score: 67.46  E-value: 2.53e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 645912966  166 TIIRQNQALRLRARKECWDRDGKERVTGEEWLVTTVGAYLP 206
Cdd:pfam01505   1 YVLSENEALRLRALEDFTDRDGVERKAGEEWLVRGPGTYIP 41
Vault pfam01505
Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ...
 324-367 7.57e-12

Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ribonucleoprotein particle of approximately 13 mDa of unknown function. This family corresponds to a repeated domain found in the amino terminal half of the major vault protein.


Pssm-ID: 460235 [Multi-domain]  Cd Length: 41  Bit Score: 60.52  E-value: 7.57e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 645912966  324 YVLSEQQGLLLRALqplEEGEDEEKVSHQAGDHWLIRGPLEYVP 367
Cdd:pfam01505   1 YVLSENEALRLRAL---EDFTDRDGVERKAGEEWLVRGPGTYIP 41
Vault pfam01505
Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ...
 220-261 1.03e-11

Major Vault Protein repeat domain; The vault is a ubiquitous and highly conserved ribonucleoprotein particle of approximately 13 mDa of unknown function. This family corresponds to a repeated domain found in the amino terminal half of the major vault protein.


Pssm-ID: 460235 [Multi-domain]  Cd Length: 41  Bit Score: 60.14  E-value: 1.03e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 645912966  220 ILTEKTALHLRARRNFRDFRGVSRRTGEEWLVTvqDTEAHVP 261
Cdd:pfam01505   2 VLSENEALRLRALEDFTDRDGVERKAGEEWLVR--GPGTYIP 41
Vault_2 pfam17794
Major Vault Protein repeat domain; This short domain is found repeated numerous times in the ...
 273-320 7.40e-09

Major Vault Protein repeat domain; This short domain is found repeated numerous times in the Major Vault Protein. This entry is related to pfam01505.


Pssm-ID: 407666 [Multi-domain]  Cd Length: 60  Bit Score: 52.47  E-value: 7.40e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966  273 ITTLGPHNYCVILDPVGPDGK-----NQLGQKRVVKGEKS-------FFLQPGEQLEQGI 320
Cdd:pfam17794   1 MITLPPRSYCVVANPVSRDGKgspvlDQHGQVRLVHGDKEirlaqdpFPLYPGEKLEGDI 60
MVP_shoulder cd08825
Shoulder domain of the major vault protein; The major vault protein is the major polypeptide ...
 734-822 4.42e-08

Shoulder domain of the major vault protein; The major vault protein is the major polypeptide component of a large cellular ribonuclear protein complex found in the cytoplasm of eukaryotic cells. Its shoulder domain appears to be a homolog of the SPFH core domain. Vault proteins may be involved in detoxification processes, and have been associated with the multi-drug resistance (MDR) phenotype in malignancies. Presumably they play a role in transport processes.


Pssm-ID: 259807  Cd Length: 151  Bit Score: 53.00  E-value: 4.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966 734 EAIGPSTIRDLAVAGPEMQVKLlQSLGLKSTLIT-DGSTPINLF--NTAFGLLGMGPEGQPLGRRVasgPSPGEGISPQS 810
Cdd:cd08825   64 KAIASRIRGAVASVTFDDFHKN-SARIIRSAVFGdDEKGEVRDElrFPANNLVITNVDIQSVEPVD---QRTRDSLQKSV 139

                         90
                 ....*....|..
gi 645912966 811 AQAPQAPGDNHV 822
Cdd:cd08825  140 QLAIEITTNSQE 151
Vault_3 pfam17795
Major Vault Protein Repeat domain; This domain is found in the Major Vault Protein.
 457-479 4.56e-06

Major Vault Protein Repeat domain; This domain is found in the Major Vault Protein.


Pssm-ID: 407667  Cd Length: 62  Bit Score: 44.75  E-value: 4.56e-06
                          10        20
                  ....*....|....*....|...
gi 645912966  457 VVSYRVPHNAAVQVYDYREKRAR 479
Cdd:pfam17795   1 VVTFRVPHNALVQLYDYKTKKSR 23
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 587-718 1.59e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 42.23  E-value: 1.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966 587 ALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKAEAESRAEA 666
Cdd:COG1196  442 EALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRG 521

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 645912966 667 arIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKA 718
Cdd:COG1196  522 --LAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKA 571
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 581-725 5.31e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.31  E-value: 5.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966 581 DQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKAEA 660
Cdd:COG1196  280 ELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAE 359

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 645912966 661 ESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVE 725
Cdd:COG1196  360 LAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELE 424
SPFH_like cd02106
core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; This model ...
 491-553 5.63e-03

core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; This model summarizes proteins similar to stomatin, prohibitin, flotillin, HflK/C (SPFH) and podocin. The conserved domain common to the SPFH superfamily has also been referred to as the Band 7 domain. Many superfamily members are associated with lipid rafts. Individual proteins of the SPFH superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Microdomains formed from flotillin proteins may in addition be dynamic units with their own regulatory functions. Flotillins have been implicated in signal transduction, vesicle trafficking, cytoskeleton rearrangement and are known to interact with a variety of proteins. Stomatin interacts with and regulates members of the degenerin/epithelia Na+ channel family in mechanosensory cells of Caenorhabditis elegans and vertebrate neurons, and participates in trafficking of Glut1 glucose transporters. Prohibitin may act as a chaperone for the stabilization of mitochondrial proteins. Prokaryotic HflK/C plays a role in the decision between lysogenic and lytic cycle growth during lambda phage infection. Flotillins have been implicated in the progression of prion disease, in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's disease, and in cancer invasion and metastasis. Mutations in the podocin gene give rise to autosomal recessive steroid resistant nephritic syndrome.


Pssm-ID: 259797 [Multi-domain]  Cd Length: 110  Bit Score: 37.34  E-value: 5.63e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 645912966 491 ETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNsARIIRTAVFGFETsEAKGPDGMAL 553
Cdd:cd02106   38 AFYLVDFVKDIKADIRRKIADVLRAAIGRMTLDQIISG-RDEIAKAVKEDLE-EDLENFGVVI 98
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 578-725 7.03e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.92  E-value: 7.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 645912966 578 EPVDQRTRDALQRSVQLAIEITtnSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAK 657
Cdd:COG1196  305 ARLEERRRELEERLEELEEELA--ELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELE 382

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 645912966 658 AEAESRaeaarIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVE 725
Cdd:COG1196  383 ELAEEL-----LEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALE 445
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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