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Conserved domains on  [gi|651167113|ref|NP_001280563|]
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deformed epidermal autoregulatory factor 1 homolog isoform b [Homo sapiens]

Protein Classification

zinc finger MYND domain-containing protein; PWWP and zinc finger MYND domain-containing protein( domain architecture ID 10245136)

MYND (myeloid-Nervy-DEAF-1) domain-containing protein, defined by a C6HC zinc-chelating motif, does not bind DNA, but instead mediates interactions with other proteins; PWWP and zinc finger MYND domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-MYND pfam01753
MYND finger;
429-465 7.86e-13

MYND finger;


:

Pssm-ID: 460312  Cd Length: 39  Bit Score: 62.44  E-value: 7.86e-13
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 651167113  429 CVNCGREAMSE--CTGCHKVNYCSTFCQRKDWKDHQHIC 465
Cdd:pfam01753   1 CAVCGKEALKLlrCSRCKSVYYCSKECQKADWPYHKKEC 39
SAND super family cl02536
SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The ...
 201-222 2.54e-03

SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The conserved KDWK motif is necessary for DNA binding, and it appears to be important for dimerization. This region is also found in the putative transcription factor RegA from the multicellular green alga Volvox cateri. This region of RegA is known as the VARL domain.


The actual alignment was detected with superfamily member smart00258:

Pssm-ID: 470606  Cd Length: 73  Bit Score: 36.55  E-value: 2.54e-03
                           10        20
                   ....*....|....*....|..
gi 651167113   201 SELPVRCRNISGTLYKNRLGSG 222
Cdd:smart00258   1 SELPVTCGTVKGILYKKKFKCG 22
 
Name Accession Description Interval E-value
zf-MYND pfam01753
MYND finger;
429-465 7.86e-13

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 62.44  E-value: 7.86e-13
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 651167113  429 CVNCGREAMSE--CTGCHKVNYCSTFCQRKDWKDHQHIC 465
Cdd:pfam01753   1 CAVCGKEALKLlrCSRCKSVYYCSKECQKADWPYHKKEC 39
SAND smart00258
SAND domain;
201-222 2.54e-03

SAND domain;


Pssm-ID: 128554  Cd Length: 73  Bit Score: 36.55  E-value: 2.54e-03
                           10        20
                   ....*....|....*....|..
gi 651167113   201 SELPVRCRNISGTLYKNRLGSG 222
Cdd:smart00258   1 SELPVTCGTVKGILYKKKFKCG 22
SAND pfam01342
SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The ...
 200-222 9.34e-03

SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The conserved KDWK motif is necessary for DNA binding, and it appears to be important for dimerization. This region is also found in the putative transcription factor RegA from the multicellular green alga Volvox cateri. This region of RegA is known as the VARL domain.


Pssm-ID: 460167  Cd Length: 76  Bit Score: 35.25  E-value: 9.34e-03
                          10        20
                  ....*....|....*....|...
gi 651167113  200 DSELPVRCRNISGTLYKNRLGSG 222
Cdd:pfam01342   4 SPVLPVTCGAAKGLLHKKKFKQG 26
 
Name Accession Description Interval E-value
zf-MYND pfam01753
MYND finger;
429-465 7.86e-13

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 62.44  E-value: 7.86e-13
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 651167113  429 CVNCGREAMSE--CTGCHKVNYCSTFCQRKDWKDHQHIC 465
Cdd:pfam01753   1 CAVCGKEALKLlrCSRCKSVYYCSKECQKADWPYHKKEC 39
SAND smart00258
SAND domain;
201-222 2.54e-03

SAND domain;


Pssm-ID: 128554  Cd Length: 73  Bit Score: 36.55  E-value: 2.54e-03
                           10        20
                   ....*....|....*....|..
gi 651167113   201 SELPVRCRNISGTLYKNRLGSG 222
Cdd:smart00258   1 SELPVTCGTVKGILYKKKFKCG 22
SAND pfam01342
SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The ...
 200-222 9.34e-03

SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The conserved KDWK motif is necessary for DNA binding, and it appears to be important for dimerization. This region is also found in the putative transcription factor RegA from the multicellular green alga Volvox cateri. This region of RegA is known as the VARL domain.


Pssm-ID: 460167  Cd Length: 76  Bit Score: 35.25  E-value: 9.34e-03
                          10        20
                  ....*....|....*....|...
gi 651167113  200 DSELPVRCRNISGTLYKNRLGSG 222
Cdd:pfam01342   4 SPVLPVTCGAAKGLLHKKKFKQG 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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