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Conserved domains on  [gi|654824169|ref|NP_001280571|]
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carbonic anhydrase 12 isoform 3 precursor [Homo sapiens]

Protein Classification

carbonic anhydrase family protein( domain architecture ID 275)

carbonic anhydrase family protein similar to carbonic anhydrase, which catalyzes the reversible hydration of gaseous carbon dioxide to carbonic acid

CATH:  3.10.200.10
Gene Ontology:  GO:0004089|GO:0008270|GO:0006730
PubMed:  10978542|18336305
SCOP:  4002732

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
alpha_CA super family cl00012
Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are ...
 36-229 2.60e-135

Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues and a fourth conserved histidine plays a potential role in proton transfer.


The actual alignment was detected with superfamily member cd03126:

Pssm-ID: 469577  Cd Length: 249  Bit Score: 382.26  E-value: 2.60e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169  36 VKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIE 115
Cdd:cd03126   58 VQLSLPPTMHIGGLPFKYTASQLHLHWGQRGSPEGSEHTISGKHFAAELHIVHYNSDKYPDISTAMNKSQGLAVLGILIE 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169 116 MGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALET 195
Cdd:cd03126  138 VGPFNPSYEKIFSHLHEVKYKDQKVSVPGFNVQELLPKRLDEYYRYEGSLTTPPCYPSVLWTVFRNPVQISQEQLLALET 217

                        170       180       190
                 ....*....|....*....|....*....|....
gi 654824169 196 ALYCTHMDdpSPREMINNFRQVQKFDERLVYTSF 229
Cdd:cd03126  218 ALYSTEED--ESREMVNNYRQVQPFNERLVFASF 249
 
Name Accession Description Interval E-value
alpha_CA_XII_XIV cd03126
Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing ...
 36-229 2.60e-135

Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane proteins CA XII and XIV.


Pssm-ID: 239400  Cd Length: 249  Bit Score: 382.26  E-value: 2.60e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169  36 VKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIE 115
Cdd:cd03126   58 VQLSLPPTMHIGGLPFKYTASQLHLHWGQRGSPEGSEHTISGKHFAAELHIVHYNSDKYPDISTAMNKSQGLAVLGILIE 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169 116 MGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALET 195
Cdd:cd03126  138 VGPFNPSYEKIFSHLHEVKYKDQKVSVPGFNVQELLPKRLDEYYRYEGSLTTPPCYPSVLWTVFRNPVQISQEQLLALET 217

                        170       180       190
                 ....*....|....*....|....*....|....
gi 654824169 196 ALYCTHMDdpSPREMINNFRQVQKFDERLVYTSF 229
Cdd:cd03126  218 ALYSTEED--ESREMVNNYRQVQPFNERLVFASF 249
Carb_anhydrase pfam00194
Eukaryotic-type carbonic anhydrase;
28-229 1.67e-88

Eukaryotic-type carbonic anhydrase;


Pssm-ID: 459707 [Multi-domain]  Cd Length: 252  Bit Score: 263.74  E-value: 1.67e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169   28 NGSKWTYFVKLNLPSDMHIQGLQSRYSATQLHLHWGNpNDPHGSEHTVSGQHFAAELHIVHYNSDlYPDASTASNKSEGL 107
Cdd:pfam00194  54 NGHTVQVSLDDGDPSTISGGPLATRYRLVQFHFHWGS-TDSRGSEHTIDGKRYPAELHIVHYNSK-YKSFDEAAKHPDGL 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169  108 AVLAVLIEMG-SFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQIS 186
Cdd:pfam00194 132 AVLGVFFEVGdENNPYLQPIVSALDNIKYKGKSVLLPPFDLSDLLPEDLTSYYTYNGSLTTPPCSESVTWIVFKEPISIS 211

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 654824169  187 QEQLLALETALYCTHMDDPSPreMINNFRQVQKFDERLVYTSF 229
Cdd:pfam00194 212 EEQLEAFRTLLFSDGGEEPRP--LVNNFRPTQPLNGRVVFASF 252
Carb_anhydrase smart01057
Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse ...
 34-223 1.12e-72

Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse the reversible hydration of carbon dioxide to bicarbonate.. CAs have essential roles in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space; they are also involved in many other processes, from respiration and photosynthesis in eukaryotes to cyanate degradation in prokaryotes. There are five known evolutionarily distinct CA families (alpha, beta, gamma, delta and epsilon) that have no significant sequence identity and have structurally distinct overall folds. Some CAs are membrane-bound, while others act in the cytosol; there are several related proteins that lack enzymatic activity. The active site of alpha-CAs is well described, consisting of a zinc ion coordinated through 3 histidine residues and a water molecule/hydroxide ion that acts as a potent nucleophile. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site. Beta- and gamma-CAs also employ a zinc hydroxide mechanism, although at least some beta-class enzymes do not have water directly coordinated to the metal ion.


Pssm-ID: 215000 [Multi-domain]  Cd Length: 247  Bit Score: 223.34  E-value: 1.12e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169    34 YFVKLNLPSD-MHIQG--LQSRYSATQLHLHWGNpNDPHGSEHTVSGQHFAAELHIVHYNSDlyPDASTASNKSEGLAVL 110
Cdd:smart01057  61 HTVQVNFDDDgSTLSGgpLPGRYRLKQFHFHWGG-SDSEGSEHTIDGKRFPLELHLVHYNSK--GSFSEAVSKPGGLAVV 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169   111 AVLIEMGS-FNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQ 189
Cdd:smart01057 138 AVFFKVGAeENPALQAILDHLPLIKYKGQETELTPFDLSSLLPASTRHYYTYNGSLTTPPCSEGVTWIVFKEPITISTEQ 217

                          170       180       190
                   ....*....|....*....|....*....|....
gi 654824169   190 LLALETaLYCTHMDDPspreMINNFRQVQKFDER 223
Cdd:smart01057 218 LEKFRT-LLPMEGNEP----LVNNARPLQPLNGR 246
Cah COG3338
Carbonic anhydrase [Inorganic ion transport and metabolism];
36-228 4.19e-40

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 442567 [Multi-domain]  Cd Length: 247  Bit Score: 139.63  E-value: 4.19e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169  36 VKLNLPSDMHIQGLQSRYSATQLHLHwgnpndpHGSEHTVSGQHFAAELHIVHYNSDlypdastasnkseG-LAVLAVLI 114
Cdd:COG3338   89 IQVNVDPGSTLTVDGKRYELKQFHFH-------TPSEHTINGKSYPMEAHLVHKDAD-------------GeLAVVGVLF 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169 115 EMGSFNPSYDKIFSHLQhvKYKGQEAFVP-GFNIEELLPERTAeYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLAL 193
Cdd:COG3338  149 EEGAENPALAKLWANLP--LEAGEEVALDaTIDLNDLLPEDRS-YYRYSGSLTTPPCSEGVLWIVLKQPITVSAEQIEAF 225

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 654824169 194 ETALYcthmddpspremiNNFRQVQKFDERLVYTS 228
Cdd:COG3338  226 ARLYP-------------NNARPVQPLNGRLILES 247
PLN02202 PLN02202
carbonate dehydratase
 56-222 6.32e-16

carbonate dehydratase


Pssm-ID: 177853 [Multi-domain]  Cd Length: 284  Bit Score: 75.86  E-value: 6.32e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169  56 TQLHLHWGNPndphgSEHTVSGQHFAAELHIVHynsdlypdastaSNKSEGLAVLAVLIEMGSFNPSYDKI---FSHLQH 132
Cdd:PLN02202 114 TLLQMHWHTP-----SEHHLHGVQYAAELHMVH------------QAKDGSFAVVASLFKIGTEEPFLSQMkdkLVKLKE 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169 133 VKYKG-QEAFVPGFNIEELLPER-TAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREM 210
Cdd:PLN02202 177 ERFKGnHTAQVEVGKIDTRHIERkTRKYFRYIGSLTTPPCSENVSWTILGKVRSMSKEQVELLRSPLDKSFKNNSRPCQP 256

                        170
                 ....*....|..
gi 654824169 211 INNfRQVQKFDE 222
Cdd:PLN02202 257 LNG-RRVEMFHD 267
 
Name Accession Description Interval E-value
alpha_CA_XII_XIV cd03126
Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing ...
 36-229 2.60e-135

Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane proteins CA XII and XIV.


Pssm-ID: 239400  Cd Length: 249  Bit Score: 382.26  E-value: 2.60e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169  36 VKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIE 115
Cdd:cd03126   58 VQLSLPPTMHIGGLPFKYTASQLHLHWGQRGSPEGSEHTISGKHFAAELHIVHYNSDKYPDISTAMNKSQGLAVLGILIE 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169 116 MGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALET 195
Cdd:cd03126  138 VGPFNPSYEKIFSHLHEVKYKDQKVSVPGFNVQELLPKRLDEYYRYEGSLTTPPCYPSVLWTVFRNPVQISQEQLLALET 217

                        170       180       190
                 ....*....|....*....|....*....|....
gi 654824169 196 ALYCTHMDdpSPREMINNFRQVQKFDERLVYTSF 229
Cdd:cd03126  218 ALYSTEED--ESREMVNNYRQVQPFNERLVFASF 249
alpha_CA_VI_IX_XII_XIV cd03123
Carbonic anhydrase alpha, isozymes VI, IX, XII and XIV. Carbonic anhydrases (CAs) are ...
 36-229 2.83e-114

Carbonic anhydrase alpha, isozymes VI, IX, XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Alpha CAs are mostly monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the secreted CA VI, which is found in saliva, for example, and the membrane proteins CA IX, XII, and XIV.


Pssm-ID: 239397 [Multi-domain]  Cd Length: 248  Bit Score: 328.88  E-value: 2.83e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169  36 VKLNLPSDMHIQGLQSR-YSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLI 114
Cdd:cd03123   58 VQLSLPPTMHIRGGPGTeYTAAQLHLHWGGRGSLSGSEHTIDGIRFAAELHIVHYNSDKYSSFDEAADKPDGLAVLAILI 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169 115 EMG-SFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLAL 193
Cdd:cd03123  138 EVGyPENTYYEKIISHLHEIKYKGQETTVPGFNVRELLPEDLSHYYRYEGSLTTPPCYESVLWTVFRDPVTLSKEQLETL 217

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 654824169 194 ETALYCTHmddpsPREMINNFRQVQKFDERLVYTSF 229
Cdd:cd03123  218 ENTLMDTH-----NKTLQNNYRATQPLNGRVVEASF 248
Carb_anhydrase pfam00194
Eukaryotic-type carbonic anhydrase;
28-229 1.67e-88

Eukaryotic-type carbonic anhydrase;


Pssm-ID: 459707 [Multi-domain]  Cd Length: 252  Bit Score: 263.74  E-value: 1.67e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169   28 NGSKWTYFVKLNLPSDMHIQGLQSRYSATQLHLHWGNpNDPHGSEHTVSGQHFAAELHIVHYNSDlYPDASTASNKSEGL 107
Cdd:pfam00194  54 NGHTVQVSLDDGDPSTISGGPLATRYRLVQFHFHWGS-TDSRGSEHTIDGKRYPAELHIVHYNSK-YKSFDEAAKHPDGL 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169  108 AVLAVLIEMG-SFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQIS 186
Cdd:pfam00194 132 AVLGVFFEVGdENNPYLQPIVSALDNIKYKGKSVLLPPFDLSDLLPEDLTSYYTYNGSLTTPPCSESVTWIVFKEPISIS 211

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 654824169  187 QEQLLALETALYCTHMDDPSPreMINNFRQVQKFDERLVYTSF 229
Cdd:pfam00194 212 EEQLEAFRTLLFSDGGEEPRP--LVNNFRPTQPLNGRVVFASF 252
alpha_CA cd00326
Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are ...
 36-226 1.18e-75

Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues and a fourth conserved histidine plays a potential role in proton transfer.


Pssm-ID: 238200  Cd Length: 227  Bit Score: 230.25  E-value: 1.18e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169  36 VKLNLPSD---MHIQGLQSRYSATQLHLHWGNpNDPHGSEHTVSGQHFAAELHIVHYNSDLYPdaSTASNKSEGLAVLAV 112
Cdd:cd00326   42 VQVNFDDDggtLSGGGLPGRYKLVQFHFHWGS-ENSPGSEHTIDGKRYPLELHLVHYNSDYYS--SEAAKKPGGLAVLGV 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169 113 LIEMGS-FNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLL 191
Cdd:cd00326  119 FFEVGEkENPFLKKILDALPKIKYKGKETTLPPFDLSDLLPSSLRDYYTYEGSLTTPPCSEGVTWIVFKEPITISKEQLE 198

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 654824169 192 ALETALYCThmddpsPREMINNFRQVQKFDERLVY 226
Cdd:cd00326  199 AFRSLLDRE------GKPLVNNYRPVQPLNGRVVY 227
Carb_anhydrase smart01057
Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse ...
 34-223 1.12e-72

Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse the reversible hydration of carbon dioxide to bicarbonate.. CAs have essential roles in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space; they are also involved in many other processes, from respiration and photosynthesis in eukaryotes to cyanate degradation in prokaryotes. There are five known evolutionarily distinct CA families (alpha, beta, gamma, delta and epsilon) that have no significant sequence identity and have structurally distinct overall folds. Some CAs are membrane-bound, while others act in the cytosol; there are several related proteins that lack enzymatic activity. The active site of alpha-CAs is well described, consisting of a zinc ion coordinated through 3 histidine residues and a water molecule/hydroxide ion that acts as a potent nucleophile. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site. Beta- and gamma-CAs also employ a zinc hydroxide mechanism, although at least some beta-class enzymes do not have water directly coordinated to the metal ion.


Pssm-ID: 215000 [Multi-domain]  Cd Length: 247  Bit Score: 223.34  E-value: 1.12e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169    34 YFVKLNLPSD-MHIQG--LQSRYSATQLHLHWGNpNDPHGSEHTVSGQHFAAELHIVHYNSDlyPDASTASNKSEGLAVL 110
Cdd:smart01057  61 HTVQVNFDDDgSTLSGgpLPGRYRLKQFHFHWGG-SDSEGSEHTIDGKRFPLELHLVHYNSK--GSFSEAVSKPGGLAVV 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169   111 AVLIEMGS-FNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQ 189
Cdd:smart01057 138 AVFFKVGAeENPALQAILDHLPLIKYKGQETELTPFDLSSLLPASTRHYYTYNGSLTTPPCSEGVTWIVFKEPITISTEQ 217

                          170       180       190
                   ....*....|....*....|....*....|....
gi 654824169   190 LLALETaLYCTHMDDPspreMINNFRQVQKFDER 223
Cdd:smart01057 218 LEKFRT-LLPMEGNEP----LVNNARPLQPLNGR 246
alpha_CA_IV_XV_like cd03117
Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are ...
 36-226 1.78e-72

Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This subgroup, restricted to animals, contains isozyme IV and similar proteins such as mouse CA XV. Isozymes IV is attached to membranes via a glycosylphosphatidylinositol (GPI) tail. In mammals, Isozyme IV plays crucial roles in kidney and lung function, amongst others. This subgroup also contains the dual domain CA from the giant clam, Tridacna gigas. T. gigas CA plays a role in the movement of inorganic carbon from the surrounding seawater to the symbiotic algae found in the clam's tissues. CA XV is expressed in several species but not in humans or chimps. Similar to isozyme CA IV, CA XV attaches to membranes via a GPI tail.


Pssm-ID: 239391  Cd Length: 234  Bit Score: 222.14  E-value: 1.78e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169  36 VKLNLPSDMHIQG--LQSRYSATQLHLHWGNPNDPhGSEHTVSGQHFAAELHIVHYNSDlYPDASTASNKSEGLAVLAVL 113
Cdd:cd03117   44 VQVTLPDGAKISGggLPGTYKALQFHFHWGSNGSP-GSEHTIDGERYPMELHIVHIKES-YNSLLEALKDSDGLAVLGFF 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169 114 IEMGSF-NPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLP-ERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLL 191
Cdd:cd03117  122 IEEGEEeNTNFDPLISALSNIPQKGGSTNLTPFSLRSLLPsVLLTKYYRYNGSLTTPGCNEAVIWTVFEEPIPISRAQLD 201

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 654824169 192 ALETALYcthMDDPSPREMINNFRQVQKFDERLVY 226
Cdd:cd03117  202 AFSTVLF---FDTDNGQPMVNNFRPVQPLNGRVVY 233
alpha_CA_IX cd03150
Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes ...
 36-229 4.51e-54

Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Alpha CAs are strictly monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane protein CA IX. CA IX is functionally implicated in tumor growth and survival. CA IX is mainly present in solid tumors and its expression in normal tissues is limited to the mucosa of alimentary tract. CA IX is a transmembrane protein with two extracellular domains: carbonic anhydrase and, a proteoglycan-like segment mediating cell-cell adhesion. There is evidence for an involvement of the MAPK pathway in the regulation of CA9 expression.


Pssm-ID: 239403  Cd Length: 247  Bit Score: 175.91  E-value: 4.51e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169  36 VKLNLPSDMHIQ-GLQSRYSATQLHLHWGNPNDPhGSEHTVSGQHFAAELHIVHYNSDlYPDASTASNKSEGLAVLAVLI 114
Cdd:cd03150   58 VQLSLPSGLRMAlGPGQEYRALQLHLHWGAAGRP-GSEHTVDGHRFPAEIHVVHLSTA-FANLDEALGRPGGLAVLAAFL 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169 115 EMGSF-NPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLAL 193
Cdd:cd03150  136 AEGLHeNSAYEQLLSRLSEISEEESETVVPGLDVSALLPSDLSRYFRYEGSLTTPPCAQGVIWTVFNQTVRLSAKQLHTL 215

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 654824169 194 ETALYcthmdDPSPREMINNFRQVQKFDERLVYTSF 229
Cdd:cd03150  216 SDSLW-----GPHDSRLQLNFRATQPLNGRKIEASF 246
alpha_CA_VI cd03125
Carbonic anhydrase alpha, isozyme VI. Carbonic anhydrases (CAs) are zinc-containing enzymes ...
 36-229 7.27e-52

Carbonic anhydrase alpha, isozyme VI. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the secreted CA VI, which is found in saliva.


Pssm-ID: 239399  Cd Length: 249  Bit Score: 169.97  E-value: 7.27e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169  36 VKLNLPSDMHIQ-GLQSRYSATQLHLHWGNPN-DPHGSEHTVSGQHFAAELHIVHYNSDlYPDASTASNKSEGLAVLAVL 113
Cdd:cd03125   57 VQIDLPPTMSITtGDGTVYTAVQMHFHWGGRDsEISGSEHTIDGMRYVAELHIVHYNSK-YKSYEEAKDKPDGLAVLAFL 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169 114 IEMGSF--NPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLL 191
Cdd:cd03125  136 YKVGHYaeNTYYSDFISKLAKIKYAGQTTTLTSLDVRDMLPENLHHYYTYQGSLTTPPCTENVLWFVFDDPVTLSKTQIV 215

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 654824169 192 ALETALYcthmdDPSPREMINNFRQVQKFDERLVYTSF 229
Cdd:cd03125  216 KLENTLM-----DHHNKTIRNDYRRTQPLNHRVVEANF 248
alpha_CA_I_II_III_XIII cd03119
Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are ...
 53-229 1.17e-46

Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozymes I, II, and III, which are cytoplasmic enzymes. CA I, for example, is expressed in erythrocyes of many vertebrates; CA II is the most active cytosolic isozyme; while it is being expressed nearly ubiquitously, it comprises 95% of the renal carbonic anhydrase and is required for renal acidification; CA III has been implicated in protection from the damaging effect of oxidizing agents in hepatocytes. CAXIII may play important physiological roles in several organs.


Pssm-ID: 239393 [Multi-domain]  Cd Length: 259  Bit Score: 156.83  E-value: 1.17e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169  53 YSATQLHLHWGNPNDpHGSEHTVSGQHFAAELHIVHYNSDlYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQH 132
Cdd:cd03119   88 YRLRQFHFHWGSSDD-HGSEHTVDGVKYAAELHLVHWNSK-YGSFGEAAKQPDGLAVVGVFLKVGEANPELQKVLDALDS 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169 133 VKYKGQEAFVPGFNIEELLPErTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPreMIN 212
Cdd:cd03119  166 IKTKGKQAPFTNFDPSCLLPA-SLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQMAKFRSLLFNAEGEPPCP--MVD 242

                        170
                 ....*....|....*..
gi 654824169 213 NFRQVQKFDERLVYTSF 229
Cdd:cd03119  243 NWRPPQPLKGRKVRASF 259
alpha_CA_VII cd03149
Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are ...
 49-229 1.43e-46

Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozyme VII. CA VII is the most active cytosolic enzyme after CA II, and may be highly expressed in the brain. Human CA VII may be a target of antiepileptic sulfonamides/sulfamates.


Pssm-ID: 239402  Cd Length: 236  Bit Score: 156.15  E-value: 1.43e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169  49 LQSRYSATQLHLHWGNPNDpHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFS 128
Cdd:cd03149   60 LENPYRLKQFHFHWGAKHG-SGSEHTVDGKTFPSELHLVHWNAKKYKSFGEAAAAPDGLAVLGVFLETGDEHPGLNRLTD 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169 129 HLQHVKYKGQEAFVPGFNIEELLPeRTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSpr 208
Cdd:cd03149  139 ALYMVRFKGTKAQFLDFNPKCLLP-KSLDYWTYPGSLTTPPLNESVTWIVLKEPIPVSEKQMGKFRELLFTSEEDQRN-- 215

                        170       180
                 ....*....|....*....|.
gi 654824169 209 EMINNFRQVQKFDERLVYTSF 229
Cdd:cd03149  216 HMVNNFRPPQPLKGRTVRASF 236
alpha_CARP_receptor_like cd03122
Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related ...
 48-226 3.42e-46

Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. This sub-family of carbonic anhydrase-related domains found in tyrosine phosphatase receptors may play a role in cell adhesion.


Pssm-ID: 239396 [Multi-domain]  Cd Length: 253  Bit Score: 155.59  E-value: 3.42e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169  48 GLQSRYSATQLHLHWGNPNDpHGSEHTVSGQHFAAELHIVHYNSDLyPDASTASNKSEGLAVLAVLIEMGSF-NPSYDKI 126
Cdd:cd03122   75 PLLGRYKFSEITFHWGTCNS-DGSEHSIDGHKFPLEMQILHRNTDF-FDSFEAIKSPGGVLALAYLFELSHEdNPFLDPI 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169 127 FSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALEtALYCTHMDDPS 206
Cdd:cd03122  153 IEGLRNVSRPGKEVELPPFPLSDLLPPFTDKYYSYEGSLTTPPCSETVEWIVFREPVPISSRQLEAFR-ELLTRRQDGVM 231

                        170       180
                 ....*....|....*....|.
gi 654824169 207 PREMI-NNFRQVQKFDERLVY 226
Cdd:cd03122  232 SGDYLpNNGRPQQPLGSRTVF 252
alpha_CARP_X_XI_like cd03121
Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup ...
 52-227 3.99e-44

Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. CARP XI plays a role in the development of gastrointestinal stromal tumors.


Pssm-ID: 239395 [Multi-domain]  Cd Length: 256  Bit Score: 150.26  E-value: 3.99e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169  52 RYSATQLHLHWGNpNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSF-NPSYDKI--FS 128
Cdd:cd03121   79 RYRLEEIRLHFGR-EDEQGSEHTVNGQAFPGEVQLIHYNSELYPNFSEASKSPNGLVIVSLFVKIGETsNPELRRLtnRD 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169 129 HLQHVKYKGQEAFVPGFNIEELLPErTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALEtaLYCTHMDDPSPR 208
Cdd:cd03121  158 TITSIRYKGDAYFLQDLSIELLLPE-TDHYITYEGSLTSPGCHETVTWIILNKPIYITKEQMHSLR--LLSQNSPSQEKA 234

                        170
                 ....*....|....*....
gi 654824169 209 EMINNFRQVQKFDERLVYT 227
Cdd:cd03121  235 PMSPNFRPVQPLNNRPVRT 253
alpha_CA_prokaryotic_like cd03124
Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are ...
 52-226 1.95e-42

Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This sub-family includes bacterial carbonic anhydrase alpha, as well as plant enzymes such as tobacco nectarin III and yam dioscorin and, carbonic anhydrases from molluscs, such as nacrein, which are part of the organic matrix layer in shells. Other members of this family may be involved in maintaining pH balance, in facilitating transport of carbon dioxide or carbonic acid, or in sensing carbon dioxide levels in the environment. Dioscorin is the major storage protein of yam tubers and may play a role as an antioxidant. Tobacco Nectarin may play a role in the maintenace of pH and oxidative balance in nectar. Mollusc nacrein may participate in calcium carbonate crystal formation of the nacreous layer. This subfamily also includes three alpha carbonic anhydrases from Chlamydomonas reinhardtii (CAH 1-3). CAHs1-2 are localized in the periplasmic space. CAH1 faciliates the movement of carbon dioxide across the plasma membrane when the medium is alkaline. CAH3 is localized to the thylakoid lumen and provides CO2 to Rubisco.


Pssm-ID: 239398 [Multi-domain]  Cd Length: 216  Bit Score: 144.72  E-value: 1.95e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169  52 RYSATQLHLHwgnpndpHGSEHTVSGQHFAAELHIVHYNSDlypdastasnksEGLAVLAVLIEMGSFNPSYDKIFSHLQ 131
Cdd:cd03124   74 TYQLLQFHFH-------SPSEHLINGKRYPLEAHLVHKSKD------------GQLAVVAVLFEEGKENPFLKKILDNMP 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169 132 hvKYKGQEAFVPGF-NIEELLPERTaEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYcthmddpsprem 210
Cdd:cd03124  135 --KKEGTEVNLPAIlDPNELLPESR-SYYRYEGSLTTPPCSEGVRWIVLKQPITISKEQLAKFRAAVY------------ 199

                        170
                 ....*....|....*.
gi 654824169 211 INNFRQVQKFDERLVY 226
Cdd:cd03124  200 PNNARPVQPLNGREVL 215
alpha_CA_V cd03118
Carbonic anhydrase alpha, CA isozyme V_like subgroup. Carbonic anhydrases (CAs) are ...
 49-229 1.54e-40

Carbonic anhydrase alpha, CA isozyme V_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozyme V. CA V is the mitochondrial isozyme, which may play a role in gluconeogenesis and ureagenesis and possibly also in lipogenesis.


Pssm-ID: 239392  Cd Length: 236  Bit Score: 140.36  E-value: 1.54e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169  49 LQSRYSATQLHLHWGNPNDpHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFS 128
Cdd:cd03118   60 LENHYRLKQFHFHWGANNE-WGSEHTVDGHTYPAELHLVHWNSVKYENFEEAVMEENGLAVIGVFLKLGAHHEGLQKLVD 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169 129 HLQHVKYKGQEAFVPGFNIEELLPErTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCThmDDPSPR 208
Cdd:cd03118  139 ALPEVRHKDTVVEFNPFDPSCLLPA-CRDYWTYPGSLTTPPLTESVTWIIQKQPIEVSPSQLSVFRTLLFTS--RGEEEK 215

                        170       180
                 ....*....|....*....|.
gi 654824169 209 EMINNFRQVQKFDERLVYTSF 229
Cdd:cd03118  216 VMVNNFRPLQPLMNRKVRSSF 236
Cah COG3338
Carbonic anhydrase [Inorganic ion transport and metabolism];
36-228 4.19e-40

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 442567 [Multi-domain]  Cd Length: 247  Bit Score: 139.63  E-value: 4.19e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169  36 VKLNLPSDMHIQGLQSRYSATQLHLHwgnpndpHGSEHTVSGQHFAAELHIVHYNSDlypdastasnkseG-LAVLAVLI 114
Cdd:COG3338   89 IQVNVDPGSTLTVDGKRYELKQFHFH-------TPSEHTINGKSYPMEAHLVHKDAD-------------GeLAVVGVLF 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169 115 EMGSFNPSYDKIFSHLQhvKYKGQEAFVP-GFNIEELLPERTAeYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLAL 193
Cdd:COG3338  149 EEGAENPALAKLWANLP--LEAGEEVALDaTIDLNDLLPEDRS-YYRYSGSLTTPPCSEGVLWIVLKQPITVSAEQIEAF 225

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 654824169 194 ETALYcthmddpspremiNNFRQVQKFDERLVYTS 228
Cdd:COG3338  226 ARLYP-------------NNARPVQPLNGRLILES 247
alpha_CARP_VIII cd03120
Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins ...
 51-229 4.56e-33

Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. CARP VIII may play roles in various biological processes of the central nervous system, and could be involved in protein-protein interactions. CARP VIII has been shown to bind inositol 1,4,5-triphosphate (IP3) receptor type I (IP3RI), reducing the affinity of the receptor for IP3. IP3RI is an intracellular IP3-gated Ca2+ channel located on intracellular Ca2+ stores. IP3RI converts IP3 signaling into Ca2+ signaling thereby participating in a variety of cell functions.


Pssm-ID: 239394  Cd Length: 256  Bit Score: 121.50  E-value: 4.56e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169  51 SRYSATQLHLHWGNPNDpHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHL 130
Cdd:cd03120   75 HEFELAEVRFHWGRENQ-RGSEHTVNFKAFPMELHLIHWNSTLYSSLEEAMGKPHGIAIIALFVQIGKEHVGLKAVTEIL 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169 131 QHVKYKGQEAFVPGFNIEELLPE-RTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQ---EQLLALETALYCTHMDDPS 206
Cdd:cd03120  154 QDIQYKGKSKTIPCFNPNTLLPDpLLRDYWVYEGSLTTPPCSEGVTWILFRYPLTISQsqiEEFRRLRTHVKGAELVEGC 233

                        170       180
                 ....*....|....*....|...
gi 654824169 207 PREMINNFRQVQKFDERLVYTSF 229
Cdd:cd03120  234 DGLLGDNFRPTQPLSDRVIRAAF 256
PLN02202 PLN02202
carbonate dehydratase
 56-222 6.32e-16

carbonate dehydratase


Pssm-ID: 177853 [Multi-domain]  Cd Length: 284  Bit Score: 75.86  E-value: 6.32e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169  56 TQLHLHWGNPndphgSEHTVSGQHFAAELHIVHynsdlypdastaSNKSEGLAVLAVLIEMGSFNPSYDKI---FSHLQH 132
Cdd:PLN02202 114 TLLQMHWHTP-----SEHHLHGVQYAAELHMVH------------QAKDGSFAVVASLFKIGTEEPFLSQMkdkLVKLKE 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169 133 VKYKG-QEAFVPGFNIEELLPER-TAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREM 210
Cdd:PLN02202 177 ERFKGnHTAQVEVGKIDTRHIERkTRKYFRYIGSLTTPPCSENVSWTILGKVRSMSKEQVELLRSPLDKSFKNNSRPCQP 256

                        170
                 ....*....|..
gi 654824169 211 INNfRQVQKFDE 222
Cdd:PLN02202 257 LNG-RRVEMFHD 267
PLN02179 PLN02179
carbonic anhydrase
 50-178 6.87e-13

carbonic anhydrase


Pssm-ID: 177835  Cd Length: 235  Bit Score: 66.54  E-value: 6.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654824169  50 QSRYSATQLHlhWGNPndphgSEHTVSGQHFAAELHIVHynsdlypdaSTASNKSeglAVLAVLIEMGSFNPSYDKIfsh 129
Cdd:PLN02179 117 QTDYKLVQCH--WHSP-----SEHTINGTSYDLELHMVH---------TSASGKT---AVVGVLYKLGEPDEFLTKL--- 174

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 654824169 130 LQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTV 178
Cdd:PLN02179 175 LNGIKGVGKKEINLGIVDPRDIRFETNNFYRYIGSLTIPPCTEGVIWTV 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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