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Conserved domains on  [gi|661903003|ref|NP_001284349|]
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DNA repair protein RAD52 homolog isoform b [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rad52_Rad22 super family cl42453
Rad52/22 family double-strand break repair protein; The DNA single-strand annealing proteins ...
 38-156 6.83e-85

Rad52/22 family double-strand break repair protein; The DNA single-strand annealing proteins (SSAPs), such as RecT, Red-beta, ERF and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways. This family includes proteins related to Rad52. These proteins contain two helix-hairpin-helix motifs.


The actual alignment was detected with superfamily member TIGR00607:

Pssm-ID: 455798  Cd Length: 161  Bit Score: 248.95  E-value: 6.83e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661903003   38 AIQKALRQRLGPEYISSRMAGGGQKVCYIEGHRVINLANEMFGYNGWAHSITQQNVDFVDLNNGKFYVGVCAFVRVQLKD 117
Cdd:TIGR00607   1 AIQKALRQKLGPEYISSRSGGGGQKVCYIEGWKVINLANEIFGYNGWSHSITQQNVDFVDENNGKFSVGVCAIVRVTLKD 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 661903003  118 GSYHEDVGYGVSEGLKSKALSLEKARKEAVTDGLKRALR 156
Cdd:TIGR00607  81 GSYHEDVGYGVSENLRSKALAFEKAKKEAVTDALKRALR 119
 
Name Accession Description Interval E-value
rad52 TIGR00607
recombination protein rad52; All proteins in this family for which functions are known are ...
 38-156 6.83e-85

recombination protein rad52; All proteins in this family for which functions are known are involved in recombination and recombination repair. Their exact biochemical activity is not yet known.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129695  Cd Length: 161  Bit Score: 248.95  E-value: 6.83e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661903003   38 AIQKALRQRLGPEYISSRMAGGGQKVCYIEGHRVINLANEMFGYNGWAHSITQQNVDFVDLNNGKFYVGVCAFVRVQLKD 117
Cdd:TIGR00607   1 AIQKALRQKLGPEYISSRSGGGGQKVCYIEGWKVINLANEIFGYNGWSHSITQQNVDFVDENNGKFSVGVCAIVRVTLKD 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 661903003  118 GSYHEDVGYGVSEGLKSKALSLEKARKEAVTDGLKRALR 156
Cdd:TIGR00607  81 GSYHEDVGYGVSENLRSKALAFEKAKKEAVTDALKRALR 119
Rad52_Rad22 pfam04098
Rad52/22 family double-strand break repair protein; The DNA single-strand annealing proteins ...
 35-170 3.61e-62

Rad52/22 family double-strand break repair protein; The DNA single-strand annealing proteins (SSAPs), such as RecT, Red-beta, ERF and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways. This family includes proteins related to Rad52. These proteins contain two helix-hairpin-helix motifs.


Pssm-ID: 367812  Cd Length: 140  Bit Score: 190.62  E-value: 3.61e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661903003   35 EYQAIQKALRQRLGPEYISSRMAGGGQKVCYIEGHRVINLANEMFGYNGWAHSITQQNVDFVDLN--NGKFYVGVCAFVR 112
Cdd:pfam04098   1 EIGTLQAKLEKPLGPEYISWRPGPGGQKVAYIEGWKVINLANEVFGFNGWSSEIISIEVDFIDERpeGGKYSVGYTAVVR 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 661903003  113 VQLKDGSYHEDVGYGVSEGLKSKALSLEKARKEAVTDGLKRALRlpLLG-VSGRILYSL 170
Cdd:pfam04098  81 VTLKDGTYREDIGYGSIENAPSKGEAFEKAKKEAVTDALKRALR--QFGnVLGNCLYDK 137
RAD52 COG5055
Recombinational DNA repair protein (RAD52 pathway) [Replication, recombination and repair];
37-157 1.46e-15

Recombinational DNA repair protein (RAD52 pathway) [Replication, recombination and repair];


Pssm-ID: 444051 [Multi-domain]  Cd Length: 300  Bit Score: 73.95  E-value: 1.46e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661903003  37 QAIQKALRQRLGPEYISSRmAGGGQKVCYIEGHRVINLANEMFGYNGWAHSITQQNVDFVDLNNGKFYVGVCAFVRVQLK 116
Cdd:COG5055    5 NPQRRILEQPLKPEQIKTR-EGNGEELSYIEGWNVIQEANRIFGFADWNRGTLENVCHETLQNNDEVICLYETKVRVTVR 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 661903003 117 DgSYHEDV----GYGVSEGlKSKALSLEKARKEAVTDGLKRALRL 157
Cdd:COG5055   84 S-DDGDSIiireGFGTGEA-NSSSDAHEAAIKTAETDALKRAATT 126
 
Name Accession Description Interval E-value
rad52 TIGR00607
recombination protein rad52; All proteins in this family for which functions are known are ...
 38-156 6.83e-85

recombination protein rad52; All proteins in this family for which functions are known are involved in recombination and recombination repair. Their exact biochemical activity is not yet known.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129695  Cd Length: 161  Bit Score: 248.95  E-value: 6.83e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661903003   38 AIQKALRQRLGPEYISSRMAGGGQKVCYIEGHRVINLANEMFGYNGWAHSITQQNVDFVDLNNGKFYVGVCAFVRVQLKD 117
Cdd:TIGR00607   1 AIQKALRQKLGPEYISSRSGGGGQKVCYIEGWKVINLANEIFGYNGWSHSITQQNVDFVDENNGKFSVGVCAIVRVTLKD 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 661903003  118 GSYHEDVGYGVSEGLKSKALSLEKARKEAVTDGLKRALR 156
Cdd:TIGR00607  81 GSYHEDVGYGVSENLRSKALAFEKAKKEAVTDALKRALR 119
Rad52_Rad22 pfam04098
Rad52/22 family double-strand break repair protein; The DNA single-strand annealing proteins ...
 35-170 3.61e-62

Rad52/22 family double-strand break repair protein; The DNA single-strand annealing proteins (SSAPs), such as RecT, Red-beta, ERF and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways. This family includes proteins related to Rad52. These proteins contain two helix-hairpin-helix motifs.


Pssm-ID: 367812  Cd Length: 140  Bit Score: 190.62  E-value: 3.61e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661903003   35 EYQAIQKALRQRLGPEYISSRMAGGGQKVCYIEGHRVINLANEMFGYNGWAHSITQQNVDFVDLN--NGKFYVGVCAFVR 112
Cdd:pfam04098   1 EIGTLQAKLEKPLGPEYISWRPGPGGQKVAYIEGWKVINLANEVFGFNGWSSEIISIEVDFIDERpeGGKYSVGYTAVVR 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 661903003  113 VQLKDGSYHEDVGYGVSEGLKSKALSLEKARKEAVTDGLKRALRlpLLG-VSGRILYSL 170
Cdd:pfam04098  81 VTLKDGTYREDIGYGSIENAPSKGEAFEKAKKEAVTDALKRALR--QFGnVLGNCLYDK 137
RAD52 COG5055
Recombinational DNA repair protein (RAD52 pathway) [Replication, recombination and repair];
37-157 1.46e-15

Recombinational DNA repair protein (RAD52 pathway) [Replication, recombination and repair];


Pssm-ID: 444051 [Multi-domain]  Cd Length: 300  Bit Score: 73.95  E-value: 1.46e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661903003  37 QAIQKALRQRLGPEYISSRmAGGGQKVCYIEGHRVINLANEMFGYNGWAHSITQQNVDFVDLNNGKFYVGVCAFVRVQLK 116
Cdd:COG5055    5 NPQRRILEQPLKPEQIKTR-EGNGEELSYIEGWNVIQEANRIFGFADWNRGTLENVCHETLQNNDEVICLYETKVRVTVR 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 661903003 117 DgSYHEDV----GYGVSEGlKSKALSLEKARKEAVTDGLKRALRL 157
Cdd:COG5055   84 S-DDGDSIiireGFGTGEA-NSSSDAHEAAIKTAETDALKRAATT 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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