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Conserved domains on  [gi|661903005|ref|NP_001284350|]
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DNA repair protein RAD52 homolog isoform c [Homo sapiens]

Protein Classification

RAD52 family DNA repair protein( domain architecture ID 1904256)

RAD52 family DNA repair protein similar to DNA repair and recombination protein RAD52 that is involved in DNA double-strand break (DSB) repair and recombination, by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rad52_Rad22 super family cl42453
Rad52/22 family double-strand break repair protein; The DNA single-strand annealing proteins ...
 1-122 8.49e-78

Rad52/22 family double-strand break repair protein; The DNA single-strand annealing proteins (SSAPs), such as RecT, Red-beta, ERF and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways. This family includes proteins related to Rad52. These proteins contain two helix-hairpin-helix motifs.


The actual alignment was detected with superfamily member TIGR00607:

Pssm-ID: 455798  Cd Length: 161  Bit Score: 235.47  E-value: 8.49e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661903005    1 MFGYNGWAHSITQQNVDFVDLNNGKFYVGVCAFVRVQLKDGSYHEDVGYGVSEGLKSKALSLEKARKEAVTDGLKRALRS 80
Cdd:TIGR00607  41 IFGYNGWSHSITQQNVDFVDENNGKFSVGVCAIVRVTLKDGSYHEDVGYGVSENLRSKALAFEKAKKEAVTDALKRALRN 120

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 661903005   81 FGNALGNCILDKDYLRSLNKLPrQLPLEVDLTKAKRQDLEPS 122
Cdd:TIGR00607 121 FGNALGNCLYDKDYLRKINKLK-QLPPEFDLGNLFRQDDEPS 161
 
Name Accession Description Interval E-value
rad52 TIGR00607
recombination protein rad52; All proteins in this family for which functions are known are ...
 1-122 8.49e-78

recombination protein rad52; All proteins in this family for which functions are known are involved in recombination and recombination repair. Their exact biochemical activity is not yet known.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129695  Cd Length: 161  Bit Score: 235.47  E-value: 8.49e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661903005    1 MFGYNGWAHSITQQNVDFVDLNNGKFYVGVCAFVRVQLKDGSYHEDVGYGVSEGLKSKALSLEKARKEAVTDGLKRALRS 80
Cdd:TIGR00607  41 IFGYNGWSHSITQQNVDFVDENNGKFSVGVCAIVRVTLKDGSYHEDVGYGVSENLRSKALAFEKAKKEAVTDALKRALRN 120

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 661903005   81 FGNALGNCILDKDYLRSLNKLPrQLPLEVDLTKAKRQDLEPS 122
Cdd:TIGR00607 121 FGNALGNCLYDKDYLRKINKLK-QLPPEFDLGNLFRQDDEPS 161
Rad52_Rad22 pfam04098
Rad52/22 family double-strand break repair protein; The DNA single-strand annealing proteins ...
 1-95 1.58e-45

Rad52/22 family double-strand break repair protein; The DNA single-strand annealing proteins (SSAPs), such as RecT, Red-beta, ERF and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways. This family includes proteins related to Rad52. These proteins contain two helix-hairpin-helix motifs.


Pssm-ID: 367812  Cd Length: 140  Bit Score: 152.10  E-value: 1.58e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661903005    1 MFGYNGWAHSITQQNVDFVDLN--NGKFYVGVCAFVRVQLKDGSYHEDVGYGVSEGLKSKALSLEKARKEAVTDGLKRAL 78
Cdd:pfam04098  44 VFGFNGWSSEIISIEVDFIDERpeGGKYSVGYTAVVRVTLKDGTYREDIGYGSIENAPSKGEAFEKAKKEAVTDALKRAL 123

                          90
                  ....*....|....*..
gi 661903005   79 RSFGNALGNCILDKDYL 95
Cdd:pfam04098 124 RQFGNVLGNCLYDKEYL 140
RAD52 COG5055
Recombinational DNA repair protein (RAD52 pathway) [Replication, recombination and repair];
2-126 5.93e-09

Recombinational DNA repair protein (RAD52 pathway) [Replication, recombination and repair];


Pssm-ID: 444051 [Multi-domain]  Cd Length: 300  Bit Score: 56.62  E-value: 5.93e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661903005   2 FGYNGWAHSITQQNVDFVDLNNGKFYVGVCAFVRVQLKDgSYHEDV----GYGVSEGlKSKALSLEKARKEAVTDGLKRA 77
Cdd:COG5055   46 FGFADWNRGTLENVCHETLQNNDEVICLYETKVRVTVRS-DDGDSIiireGFGTGEA-NSSSDAHEAAIKTAETDALKRA 123

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 661903005  78 LRSFGNALGNCILDKDYLRSLNKLPRQLPLEVDLTKAKRQDLEPSVEEA 126
Cdd:COG5055  124 ATTFGNQFGLALYDDNRQNDFLRGAVNGGLVVRGDLLEYTIYFLSIVEG 172
 
Name Accession Description Interval E-value
rad52 TIGR00607
recombination protein rad52; All proteins in this family for which functions are known are ...
 1-122 8.49e-78

recombination protein rad52; All proteins in this family for which functions are known are involved in recombination and recombination repair. Their exact biochemical activity is not yet known.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129695  Cd Length: 161  Bit Score: 235.47  E-value: 8.49e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661903005    1 MFGYNGWAHSITQQNVDFVDLNNGKFYVGVCAFVRVQLKDGSYHEDVGYGVSEGLKSKALSLEKARKEAVTDGLKRALRS 80
Cdd:TIGR00607  41 IFGYNGWSHSITQQNVDFVDENNGKFSVGVCAIVRVTLKDGSYHEDVGYGVSENLRSKALAFEKAKKEAVTDALKRALRN 120

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 661903005   81 FGNALGNCILDKDYLRSLNKLPrQLPLEVDLTKAKRQDLEPS 122
Cdd:TIGR00607 121 FGNALGNCLYDKDYLRKINKLK-QLPPEFDLGNLFRQDDEPS 161
Rad52_Rad22 pfam04098
Rad52/22 family double-strand break repair protein; The DNA single-strand annealing proteins ...
 1-95 1.58e-45

Rad52/22 family double-strand break repair protein; The DNA single-strand annealing proteins (SSAPs), such as RecT, Red-beta, ERF and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways. This family includes proteins related to Rad52. These proteins contain two helix-hairpin-helix motifs.


Pssm-ID: 367812  Cd Length: 140  Bit Score: 152.10  E-value: 1.58e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661903005    1 MFGYNGWAHSITQQNVDFVDLN--NGKFYVGVCAFVRVQLKDGSYHEDVGYGVSEGLKSKALSLEKARKEAVTDGLKRAL 78
Cdd:pfam04098  44 VFGFNGWSSEIISIEVDFIDERpeGGKYSVGYTAVVRVTLKDGTYREDIGYGSIENAPSKGEAFEKAKKEAVTDALKRAL 123

                          90
                  ....*....|....*..
gi 661903005   79 RSFGNALGNCILDKDYL 95
Cdd:pfam04098 124 RQFGNVLGNCLYDKEYL 140
RAD52 COG5055
Recombinational DNA repair protein (RAD52 pathway) [Replication, recombination and repair];
2-126 5.93e-09

Recombinational DNA repair protein (RAD52 pathway) [Replication, recombination and repair];


Pssm-ID: 444051 [Multi-domain]  Cd Length: 300  Bit Score: 56.62  E-value: 5.93e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661903005   2 FGYNGWAHSITQQNVDFVDLNNGKFYVGVCAFVRVQLKDgSYHEDV----GYGVSEGlKSKALSLEKARKEAVTDGLKRA 77
Cdd:COG5055   46 FGFADWNRGTLENVCHETLQNNDEVICLYETKVRVTVRS-DDGDSIiireGFGTGEA-NSSSDAHEAAIKTAETDALKRA 123

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 661903005  78 LRSFGNALGNCILDKDYLRSLNKLPRQLPLEVDLTKAKRQDLEPSVEEA 126
Cdd:COG5055  124 ATTFGNQFGLALYDDNRQNDFLRGAVNGGLVVRGDLLEYTIYFLSIVEG 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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