NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|662033843|ref|NP_001284489|]
View 

zinc finger protein 708 isoform 2 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
186-499 2.49e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.04  E-value: 2.49e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843 186 KLYKCEECGKAFNRSSNLTKHKIVHTGEKPYKC--EECGKAFKQSSNLTNHKKIHTGEKPYKC-GECGKAFTLSSHLTTH 262
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843 263 KRIHTGEKPYKCEECGKAFSVFSTLTKHKIIHTEEKPYKCEECGKAFNRSSHLTNHKVIHTGEkpykcEECGKAFTKSST 342
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSSNLSL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843 343 LTYHKVIHTGKKPYKCEECGKAFSIFSILTKHKVIHTEDkPYKCEECGKTFNYSSNFTNHKKIHTGEKPYKCEECGKSFI 422
Cdd:COG5048  187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843 423 LSSHLTTHKIIHTGE-------KPYKCKECGKAFNQSSTLMKHK--IIHTGE--KPYKCEE--CGKAFNQSPNLTKHKRI 489
Cdd:COG5048  266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                        330
                 ....*....|
gi 662033843 490 HTKEKPYKCK 499
Cdd:COG5048  346 HTSISPAKEK 355
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 128-179 1.55e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.55e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 662033843 128 GEKPYKCE--ECGKAFKKSSNLTNHK-------------------IIHTGEKPYKCEECGKAFNQSSTLTRHK 179
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMlhghqnqklhenpspekmnIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
186-499 2.49e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.04  E-value: 2.49e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843 186 KLYKCEECGKAFNRSSNLTKHKIVHTGEKPYKC--EECGKAFKQSSNLTNHKKIHTGEKPYKC-GECGKAFTLSSHLTTH 262
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843 263 KRIHTGEKPYKCEECGKAFSVFSTLTKHKIIHTEEKPYKCEECGKAFNRSSHLTNHKVIHTGEkpykcEECGKAFTKSST 342
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSSNLSL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843 343 LTYHKVIHTGKKPYKCEECGKAFSIFSILTKHKVIHTEDkPYKCEECGKTFNYSSNFTNHKKIHTGEKPYKCEECGKSFI 422
Cdd:COG5048  187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843 423 LSSHLTTHKIIHTGE-------KPYKCKECGKAFNQSSTLMKHK--IIHTGE--KPYKCEE--CGKAFNQSPNLTKHKRI 489
Cdd:COG5048  266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                        330
                 ....*....|
gi 662033843 490 HTKEKPYKCK 499
Cdd:COG5048  346 HTSISPAKEK 355
zf-H2C2_2 pfam13465
Zinc-finger double domain;
258-282 1.55e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.55e-03
                          10        20
                  ....*....|....*....|....*
gi 662033843  258 HLTTHKRIHTGEKPYKCEECGKAFS 282
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 128-179 1.55e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.55e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 662033843 128 GEKPYKCE--ECGKAFKKSSNLTNHK-------------------IIHTGEKPYKCEECGKAFNQSSTLTRHK 179
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMlhghqnqklhenpspekmnIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
146-171 2.25e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.25e-03
                          10        20
                  ....*....|....*....|....*.
gi 662033843  146 NLTNHKIIHTGEKPYKCEECGKAFNQ 171
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
186-499 2.49e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.04  E-value: 2.49e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843 186 KLYKCEECGKAFNRSSNLTKHKIVHTGEKPYKC--EECGKAFKQSSNLTNHKKIHTGEKPYKC-GECGKAFTLSSHLTTH 262
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843 263 KRIHTGEKPYKCEECGKAFSVFSTLTKHKIIHTEEKPYKCEECGKAFNRSSHLTNHKVIHTGEkpykcEECGKAFTKSST 342
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSSNLSL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843 343 LTYHKVIHTGKKPYKCEECGKAFSIFSILTKHKVIHTEDkPYKCEECGKTFNYSSNFTNHKKIHTGEKPYKCEECGKSFI 422
Cdd:COG5048  187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843 423 LSSHLTTHKIIHTGE-------KPYKCKECGKAFNQSSTLMKHK--IIHTGE--KPYKCEE--CGKAFNQSPNLTKHKRI 489
Cdd:COG5048  266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                        330
                 ....*....|
gi 662033843 490 HTKEKPYKCK 499
Cdd:COG5048  346 HTSISPAKEK 355
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
130-498 3.31e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.10  E-value: 3.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843 130 KPYKCEECGKAFKKSSNLTNHKIIHTGEKPYKCEECGKAFNQSST--LTRHKIIHTGEKLYKCE---------------- 191
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSkslplsnskassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843 192 ECGKAFNRSSNLTKHKIVHTGEKP------YKCEECGKAFKQSSNLTNHKKIHTGEKPYKCGEC-GKAFTLSSHLTTHKR 264
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPqlpdllSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSlSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843 265 IHTGEKPYKCEECGKAFSVFSTLTKHKIIHTEEKPYKCEECGKAF----NRSSHLTNHKVIHTGEKPYKCEECG--KAFT 338
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpkslLSQSPSSLSSSDSSSSASESPRSSLptASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843 339 KSSTLTYHKVIHTGK-KPYKCEECGKAFSIFSILTKHK--VIHT--EDKPYKCEE--CGKTFNYSSNFTNHKKIHTGEKP 411
Cdd:COG5048  272 SSSPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLrsVNHSgeSLKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843 412 YKC--EECGKSFILSS----HLTTHKIIHTGEKPYKC---KECGKAFNQSSTLMKHKIIHTGEKP--YKCEECGKAFNQS 480
Cdd:COG5048  352 AKEklLNSSSKFSPLLnnepPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRH 431

                        410
                 ....*....|....*...
gi 662033843 481 PNLTKHKRIHTKEKPYKC 498
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLC 449
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
78-488 1.44e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 1.44e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843  78 CDKYVKVFHKYSNAKRHKIRHTGKNPFKC--KECGKSFCMLSQLTQHEIIHTGEKPYKCE--ECGKAFKKSSNLTNHKiI 153
Cdd:COG5048   36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSksLPLSNSKASSSSLSSS-S 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843 154 HTGEKPYKCEECGKAFNQSSTLTRHKIIHTGEKLYKCEECGKAFNRSSNLTKHKIVHTGEkpykcEECGKAFKQSSNLTN 233
Cdd:COG5048  115 SNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSSNLSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843 234 HKKIHTGEKPYKCGECGKAFTLSSHLTTHKRIHTgEKPYKCEECGKAF-------SVFSTLTKHKIIHTEEKPYKCeECG 306
Cdd:COG5048  190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSpksllsqSPSSLSSSDSSSSASESPRSS-LPT 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843 307 KAFNRSSHLTNHKVIHTG-EKPYKCEECGKAFTKSSTLTYHK--VIHTGK--KPYKCEE--CGKAFSIFSILTKHKVIHT 379
Cdd:COG5048  268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843 380 EDKPYKCEECGKTFNYSSNFTN-------HKKIHTGEKPYKCE--ECGKSFILSSHLTTHKIIHTGEKP--YKCKECGKA 448
Cdd:COG5048  348 SISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKS 427

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 662033843 449 FNQSSTLMKHKIIHTGEKPYKCEECGKaFNQSPNLTKHKR 488
Cdd:COG5048  428 FNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
214-376 1.80e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 1.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843 214 KPYKCEECGKAFKQSSNLTNHK--KIHTGE--KPYKCGE--CGKAFTLSSHLTTHKRIHTGEKPYKC--EECGKAFSVFS 285
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843 286 T-----LTKHKIIHTEEKPYKCE--ECGKAFNRSSHLTNHKVIHTGEKP--YKCEECGKAFTKSSTLTYHKVIHTGKKPY 356
Cdd:COG5048  368 NneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170       180
                 ....*....|....*....|
gi 662033843 357 KCEECGKAFSIFSILTKHKV 376
Cdd:COG5048  448 LCSILKSFRRDLDLSNHGKD 467
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 324-404 8.19e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 48.18  E-value: 8.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843 324 GEKPYKCE--ECGKAFTKSSTLTYHKvIHTGKKPYKCEECGKafsifsilTKHKVIHTEDKPYKCEECGKTFNYSSNFTN 401
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM-LHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 662033843 402 HKK 404
Cdd:COG5189  417 HRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 156-236 1.96e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.02  E-value: 1.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843 156 GEKPYKCE--ECGKAFNQSSTLTRHKiihtgeklyKCEECGKAFNRSSNLTKHKIVHTGEKPYKCEECGKAFKQSSNLTN 233
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 662033843 234 HKK 236
Cdd:COG5189  417 HRK 419
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
131-348 3.11e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 3.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843 131 PYKCEECGKAFKKSSNLTNHKIIHTGEKPYKCEECGKAFNQSSTLTRHKIIHTGE-------KLYKCEECGKAFNRSSNL 203
Cdd:COG5048  226 SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPL 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843 204 TKHK--IVHTGE--KPYKCEE--CGKAFKQSSNLTNHKKIHTGEKPYKC--GECGKAFTLSS----HLTTHKRIHTGEKP 271
Cdd:COG5048  306 TRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnnepPQSLQQYKDLKNDK 385

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843 272 YKC---EECGKAFSVFSTLTKHKIIHTEEKP--YKCEECGKAFNRSSHLTNHKVIHTGEKPYKCEECGKAFTKSSTLTYH 346
Cdd:COG5048  386 KSEtlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHG 465


                 ..
gi 662033843 347 KV 348
Cdd:COG5048  466 KD 467
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 240-319 1.35e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843 240 GEKPYKCG--ECGKAFTLSSHLTTHkRIHTGEKPYKCEECGKafsvfstlTKHKIIHTEEKPYKCEECGKAFNRSSHLTN 317
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 662033843 318 HK 319
Cdd:COG5189  417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
258-282 1.55e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.55e-03
                          10        20
                  ....*....|....*....|....*
gi 662033843  258 HLTTHKRIHTGEKPYKCEECGKAFS 282
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
455-479 1.55e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.55e-03
                          10        20
                  ....*....|....*....|....*
gi 662033843  455 LMKHKIIHTGEKPYKCEECGKAFNQ 479
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 128-179 1.55e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.55e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 662033843 128 GEKPYKCE--ECGKAFKKSSNLTNHK-------------------IIHTGEKPYKCEECGKAFNQSSTLTRHK 179
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMlhghqnqklhenpspekmnIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
202-227 2.18e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.18e-03
                          10        20
                  ....*....|....*....|....*.
gi 662033843  202 NLTKHKIVHTGEKPYKCEECGKAFKQ 227
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
146-171 2.25e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.25e-03
                          10        20
                  ....*....|....*....|....*.
gi 662033843  146 NLTNHKIIHTGEKPYKCEECGKAFNQ 171
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 268-347 2.42e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843 268 GEKPYKCE--ECGKAFSVFSTLTKHKIiHTEEKPYKCEECGKafnrsshlTNHKVIHTGEKPYKCEECGKAFTKSSTLTY 345
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 662033843 346 HK 347
Cdd:COG5189  417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
426-451 2.48e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.48e-03
                          10        20
                  ....*....|....*....|....*.
gi 662033843  426 HLTTHKIIHTGEKPYKCKECGKAFNQ 451
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 408-487 2.55e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 2.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662033843 408 GEKPYKCE--ECGKSFILSSHLTTHKiihtgekpyKCKECGKAFNQSSTLMKHKIIHTGEKPYKCEECGKAFNQSPNLTK 485
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 662033843 486 HK 487
Cdd:COG5189  417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
230-254 4.47e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.47e-03
                          10        20
                  ....*....|....*....|....*
gi 662033843  230 NLTNHKKIHTGEKPYKCGECGKAFT 254
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
119-143 4.98e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.98e-03
                          10        20
                  ....*....|....*....|....*
gi 662033843  119 LTQHEIIHTGEKPYKCEECGKAFKK 143
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
398-421 6.37e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.37e-03
                          10        20
                  ....*....|....*....|....
gi 662033843  398 NFTNHKKIHTGEKPYKCEECGKSF 421
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
314-339 9.25e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.25e-03
                          10        20
                  ....*....|....*....|....*.
gi 662033843  314 HLTNHKVIHTGEKPYKCEECGKAFTK 339
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH