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Conserved domains on  [gi|662236802|ref|NP_001284521|]
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protein sel-1 homolog 3 isoform 2 [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11434433)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
644-835 2.51e-37

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 140.83  E-value: 2.51e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236802  644 WLKHEATRGNAAAQQRLAQMLFWGQqGVAKNPEAAIEWYAKGAlETEDPALIYDYAIVLFKGQGVKKNRRLALELMKKAA 723
Cdd:COG0790    53 AAAAAAAAGGAEAQYNLGLMYAEGR-GVPKDYEKALEWFEKAA-EQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAA 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236802  724 SKGLHQAVNGLGWYYHK---FKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGGHM 800
Cdd:COG0790   131 EQGDADAQYNLGLLYLNgegVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGR--GVP-KDPAKALEWYRKAAEQGDA 207

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 662236802  801 EGTLWCSLYYITGnlETFPRDPEKAVVWAKHVAEK 835
Cdd:COG0790   208 DAQYNLGRLYLNG--EGVEKDLEKALRWLRKAAEQ 240
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
644-835 2.51e-37

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 140.83  E-value: 2.51e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236802  644 WLKHEATRGNAAAQQRLAQMLFWGQqGVAKNPEAAIEWYAKGAlETEDPALIYDYAIVLFKGQGVKKNRRLALELMKKAA 723
Cdd:COG0790    53 AAAAAAAAGGAEAQYNLGLMYAEGR-GVPKDYEKALEWFEKAA-EQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAA 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236802  724 SKGLHQAVNGLGWYYHK---FKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGGHM 800
Cdd:COG0790   131 EQGDADAQYNLGLLYLNgegVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGR--GVP-KDPAKALEWYRKAAEQGDA 207

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 662236802  801 EGTLWCSLYYITGnlETFPRDPEKAVVWAKHVAEK 835
Cdd:COG0790   208 DAQYNLGRLYLNG--EGVEKDLEKALRWLRKAAEQ 240
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 696-726 1.03e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 40.58  E-value: 1.03e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 662236802   696 YDYAIVLFKGQGVKKNRRLALELMKKAASKG 726
Cdd:pfam08238    5 YRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 761-799 8.66e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 37.92  E-value: 8.66e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 662236802    761 PDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGGH 799
Cdd:smart00671    1 AEAQYNLGQMYEYGL--GVP-KDLEKALEYYKKAAELGN 36
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
644-835 2.51e-37

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 140.83  E-value: 2.51e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236802  644 WLKHEATRGNAAAQQRLAQMLFWGQqGVAKNPEAAIEWYAKGAlETEDPALIYDYAIVLFKGQGVKKNRRLALELMKKAA 723
Cdd:COG0790    53 AAAAAAAAGGAEAQYNLGLMYAEGR-GVPKDYEKALEWFEKAA-EQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAA 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236802  724 SKGLHQAVNGLGWYYHK---FKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGGHM 800
Cdd:COG0790   131 EQGDADAQYNLGLLYLNgegVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGR--GVP-KDPAKALEWYRKAAEQGDA 207

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 662236802  801 EGTLWCSLYYITGnlETFPRDPEKAVVWAKHVAEK 835
Cdd:COG0790   208 DAQYNLGRLYLNG--EGVEKDLEKALRWLRKAAEQ 240
TPR COG0790
TPR repeat [General function prediction only];
642-796 9.84e-32

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 124.66  E-value: 9.84e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236802  642 FMWLKHEATRGNAAAQQRLAQMLFWGqQGVAKNPEAAIEWYAKGAlETEDPALIYDYAIVLFKGQGVKKNRRLALELMKK 721
Cdd:COG0790    87 LEWFEKAAEQGDAEAQYNLGLMYEEG-LGVPQDYAKALEWYEKAA-EQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRK 164

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 662236802  722 AASKGLHQAVNGLGWYYHK---FKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQ 796
Cdd:COG0790   165 AAEQGDADAQYNLGVLYENgrgVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGE--GVE-KDLEKALRWLRKAAE 239
TPR COG0790
TPR repeat [General function prediction only];
643-867 1.48e-28

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 115.41  E-value: 1.48e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236802  643 MWLKHEATRGNAAAQQRLAQMLFWGQQGVAKNPEAAIEWYAKGALETEDPALiYDYAIVLFKGQGVKKNRRLALELMKKA 722
Cdd:COG0790    15 AAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQ-YNLGLMYAEGRGVPKDYEKALEWFEKA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236802  723 ASKGLHQAVNGLGWYYHK---FKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGGH 799
Cdd:COG0790    94 AEQGDAEAQYNLGLMYEEglgVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGE--GVP-KDPAKAAEWYRKAAEQGD 170

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 662236802  800 MEGTLWCSLYYITGnlETFPRDPEKAVVWAKHVAEKN-----GYLGHVIRKGLnaYLEGSWHEALLYYVLAAE 867
Cdd:COG0790   171 ADAQYNLGVLYENG--RGVPKDPAKALEWYRKAAEQGdadaqYNLGRLYLNGE--GVEKDLEKALRWLRKAAE 239
TPR COG0790
TPR repeat [General function prediction only];
666-892 8.29e-21

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 92.68  E-value: 8.29e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236802  666 WGQQGVAKNPEAAIEWYAKGALETEDPALIYDYAIVLFKGQGVKKNRRLALELMKKAASKGLHQAVNGLGWYYHK---FK 742
Cdd:COG0790     1 LALAAAAAAAAAAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEgrgVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236802  743 KNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGGHMEGTLWCSLYYITGnlETFPRDP 822
Cdd:COG0790    81 KDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGL--GVP-QDYAKALEWYEKAAEQGDADAQYNLGLLYLNG--EGVPKDP 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236802  823 EKAVVWAKHVAEkNGY------LGHVIRKGLnaYLEGSWHEALLYYVLAAETGIEVSQTNLAHI------CEERPDLARR 890
Cdd:COG0790   156 AKAAEWYRKAAE-QGDadaqynLGVLYENGR--GVPKDPAKALEWYRKAAEQGDADAQYNLGRLylngegVEKDLEKALR 232


                  ..
gi 662236802  891 YL 892
Cdd:COG0790   233 WL 234
TPR COG0790
TPR repeat [General function prediction only];
713-966 4.75e-11

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 64.18  E-value: 4.75e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236802  713 RLALELMKKAASKGLHQAVNGLGWYYHKFKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIfpGVPgRNQTLAGEYFH 792
Cdd:COG0790    15 AAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGR--GVP-KDYEKALEWFE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236802  793 KAAQGGHMEGTLWCSLYYITGnlETFPRDPEKAVVWakhvaekngylghvirkglnaylegswheallyYVLAAETGIEV 872
Cdd:COG0790    92 KAAEQGDAEAQYNLGLMYEEG--LGVPQDYAKALEW---------------------------------YEKAAEQGDAD 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236802  873 SQTNLahiceerpdlarrylgvncvwryynfsvfqidapsfaylkmGDLYYYGHQNQsQDLELSVQMYAQAALDGDSQGF 952
Cdd:COG0790   137 AQYNL-----------------------------------------GLLYLNGEGVP-KDPAKAAEWYRKAAEQGDADAQ 174

                         250
                  ....*....|....
gi 662236802  953 FNLALLIEEGTIIP 966
Cdd:COG0790   175 YNLGVLYENGRGVP 188
TPR COG0790
TPR repeat [General function prediction only];
533-723 5.02e-09

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 58.02  E-value: 5.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236802  533 GYHKASYYLAVFYETGLNVPRDQLQGmlyslvggqgserlssmnlgykhyqgidnypldwelsyayysniatktpldqht 612
Cdd:COG0790   133 GDADAQYNLGLLYLNGEGVPKDPAKA------------------------------------------------------ 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236802  613 lqgdqayvetirlkddeilkvqtkedgdvFMWLKHEATRGNAAAQQRLAQMLFWGqQGVAKNPEAAIEWYAKGAlETEDP 692
Cdd:COG0790   159 -----------------------------AEWYRKAAEQGDADAQYNLGVLYENG-RGVPKDPAKALEWYRKAA-EQGDA 207

                         170       180       190
                  ....*....|....*....|....*....|.
gi 662236802  693 ALIYDYAIVLFKGQGVKKNRRLALELMKKAA 723
Cdd:COG0790   208 DAQYNLGRLYLNGEGVEKDLEKALRWLRKAA 238
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 652-763 9.33e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 49.23  E-value: 9.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236802  652 GNAAAQQRLAQMLFWgqqgvAKNPEAAIEWYAKG-ALETEDPALIYDYAIVLFKGQGVKKnrrlALELMKKAASK--GLH 728
Cdd:COG4235    15 NDAEGWLLLGRAYLR-----LGRYDEALAAYEKAlRLDPDNADALLDLAEALLAAGDTEE----AEELLERALALdpDNP 85

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 662236802  729 QAVNGLGWYYHKfKKNYAKAAKYWLKAEEMGNPDA 763
Cdd:COG4235    86 EALYLLGLAAFQ-QGDYAEAIAAWQKLLALLPADA 119
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 696-726 1.03e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 40.58  E-value: 1.03e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 662236802   696 YDYAIVLFKGQGVKKNRRLALELMKKAASKG 726
Cdd:pfam08238    5 YRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 654-686 6.55e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 38.27  E-value: 6.55e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 662236802   654 AAAQQRLAQMLFWGQqGVAKNPEAAIEWYAKGA 686
Cdd:pfam08238    1 AEAQYRLGYLYLYGL-GVPKDPEKALEWYEKAA 32
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 761-799 8.66e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 37.92  E-value: 8.66e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 662236802    761 PDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGGH 799
Cdd:smart00671    1 AEAQYNLGQMYEYGL--GVP-KDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 761-798 1.93e-03

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 36.73  E-value: 1.93e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 662236802   761 PDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGG 798
Cdd:pfam08238    1 AEAQYRLGYLYLYGL--GVP-KDPEKALEWYEKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 696-726 2.66e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 36.38  E-value: 2.66e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 662236802    696 YDYAIVLFKGQGVKKNRRLALELMKKAASKG 726
Cdd:smart00671    5 YNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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