NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|663071068|ref|NP_001284640|]
View 

microfibrillar-associated protein 5 isoform d precursor [Homo sapiens]

Protein Classification

MAGP domain-containing protein( domain architecture ID 10527539)

MAGP domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MAGP pfam05507
Microfibril-associated glycoprotein (MAGP); This family consists of several mammalian ...
 3-118 2.78e-73

Microfibril-associated glycoprotein (MAGP); This family consists of several mammalian microfibril-associated glycoprotein (MAGP) 1 and 2 proteins. MAGP1 and 2 are components of elastic fibres. MAGP-1 has been proposed to bind a C-terminal region of tropoelastin, the soluble precursor of elastin. MAGP-2 was found to interact with fibrillin-1 and -2, as well as fibulin-1, another component of elastic fibres this suggests that MAGP-2 may be important in the assembly of microfibrils.


:

Pssm-ID: 461667  Cd Length: 137  Bit Score: 215.50  E-value: 2.78e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071068    3 LLGPKVLLFLAAFIITSDWIPLGVNSQRGDDVTQATPETFTEDPNLVNDPATDET--------------------ECWDE 62
Cdd:pfam05507   2 LLGPKVLLFLTALIIASDWTPLGVSGQRGDDVTQVTQETFTDDPNLVNDPPTDETvladiepstddlassnnataECREE 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 663071068   63 KFTCTRLYSVHRPVKQCIHQLCFTSLRRMYIVNKEICSRLVCKEHEAMKDELCRQM 118
Cdd:pfam05507  82 QFPCTRLYSVHRPVKQCLHQLCFTSLRRMYIINKEICSRLVCKEHEAMKDELCRQM 137
 
Name Accession Description Interval E-value
MAGP pfam05507
Microfibril-associated glycoprotein (MAGP); This family consists of several mammalian ...
 3-118 2.78e-73

Microfibril-associated glycoprotein (MAGP); This family consists of several mammalian microfibril-associated glycoprotein (MAGP) 1 and 2 proteins. MAGP1 and 2 are components of elastic fibres. MAGP-1 has been proposed to bind a C-terminal region of tropoelastin, the soluble precursor of elastin. MAGP-2 was found to interact with fibrillin-1 and -2, as well as fibulin-1, another component of elastic fibres this suggests that MAGP-2 may be important in the assembly of microfibrils.


Pssm-ID: 461667  Cd Length: 137  Bit Score: 215.50  E-value: 2.78e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071068    3 LLGPKVLLFLAAFIITSDWIPLGVNSQRGDDVTQATPETFTEDPNLVNDPATDET--------------------ECWDE 62
Cdd:pfam05507   2 LLGPKVLLFLTALIIASDWTPLGVSGQRGDDVTQVTQETFTDDPNLVNDPPTDETvladiepstddlassnnataECREE 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 663071068   63 KFTCTRLYSVHRPVKQCIHQLCFTSLRRMYIVNKEICSRLVCKEHEAMKDELCRQM 118
Cdd:pfam05507  82 QFPCTRLYSVHRPVKQCLHQLCFTSLRRMYIINKEICSRLVCKEHEAMKDELCRQM 137
 
Name Accession Description Interval E-value
MAGP pfam05507
Microfibril-associated glycoprotein (MAGP); This family consists of several mammalian ...
 3-118 2.78e-73

Microfibril-associated glycoprotein (MAGP); This family consists of several mammalian microfibril-associated glycoprotein (MAGP) 1 and 2 proteins. MAGP1 and 2 are components of elastic fibres. MAGP-1 has been proposed to bind a C-terminal region of tropoelastin, the soluble precursor of elastin. MAGP-2 was found to interact with fibrillin-1 and -2, as well as fibulin-1, another component of elastic fibres this suggests that MAGP-2 may be important in the assembly of microfibrils.


Pssm-ID: 461667  Cd Length: 137  Bit Score: 215.50  E-value: 2.78e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071068    3 LLGPKVLLFLAAFIITSDWIPLGVNSQRGDDVTQATPETFTEDPNLVNDPATDET--------------------ECWDE 62
Cdd:pfam05507   2 LLGPKVLLFLTALIIASDWTPLGVSGQRGDDVTQVTQETFTDDPNLVNDPPTDETvladiepstddlassnnataECREE 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 663071068   63 KFTCTRLYSVHRPVKQCIHQLCFTSLRRMYIVNKEICSRLVCKEHEAMKDELCRQM 118
Cdd:pfam05507  82 QFPCTRLYSVHRPVKQCLHQLCFTSLRRMYIINKEICSRLVCKEHEAMKDELCRQM 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH