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Conserved domains on  [gi|663071081|ref|NP_001284692|]
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zinc finger protein 546 isoform 2 precursor [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
34-94 3.35e-34

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 124.63  E-value: 3.35e-34
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 663071081    34 LAFRDVSIDLSQEEWECLDAVQRDLYKDVMLENYSNLVSLGYTIPKPDVITLLEQEKEPWI 94
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
357-797 1.99e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 1.99e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 357 KPYKCNECGKAFSHGSYLVQHQKIHTGEKPYEC--KECGKSFSFHAELARHRRIHTGEKPYECRecgKAFRLQTELTRH- 433
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSs 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 434 ---HRTHTGEKPYECKECGKAFICGYQLTLHLRTHTGEIPYECKECGKTFSSRYHLTQHYRIHTGEKPYICNECGKAFRL 510
Cdd:COG5048  109 slsSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 511 QGELTRHHRIHtcekpYECKECGKAFIHSNQfISHQRIHTSESTYICKECGKIFSRRYNLTQHFKIHTGEKPYICNECGK 590
Cdd:COG5048  189 SSNVSTSIPSS-----SENSPLSSSYSIPSS-SSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 591 AFRFQTELTQHHRIHTGE-------KPYKCTECGKAFIRSTHLTQH--HRIHTGE--KPYECTE--CGKTFSRHYHLTQH 657
Cdd:COG5048  263 SSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 658 HRGHTGEKPYIC-------------NECGNAFICSYRLTLHQRIHTGELPyeckECGKTFSRRYHLTQHFRLHTGEKPYS 724
Cdd:COG5048  343 ILLHTSISPAKEkllnssskfspllNNEPPQSLQQYKDLKNDKKSETLSN----SCIRNFKRDSNLSLHIITHLSFRPYN 418

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 663071081 725 CKecgnafrlqaeltrhhivhtgekpykCKECGKAFSVNSELTRHHRIHTGEKPYQCkECGKAFIRSDQLTLH 797
Cdd:COG5048  419 CK--------------------------NPPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
189-349 1.02e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 1.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 189 KSYECKECRKAFRQQSYLIQHLR--IHTGE--RPYKCME--CGKAFCRVGDLRVHHTIHAGERPYECKEC-------GKA 255
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 256 FRLHYHLTEHQRIHSGVKPYECKECGKAFSRVRD--LRVHQTIHAGERPYECK--ECGKAFRLHYQLTEHQRIHTGERPY 331
Cdd:COG5048  368 NNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDsnLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*...
gi 663071081 332 ECKVCGKtFRVQRHISQH 349
Cdd:COG5048  448 LCSILKS-FRRDLDLSNH 464
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
34-94 3.35e-34

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 124.63  E-value: 3.35e-34
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 663071081    34 LAFRDVSIDLSQEEWECLDAVQRDLYKDVMLENYSNLVSLGYTIPKPDVITLLEQEKEPWI 94
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 33-74 1.80e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.91  E-value: 1.80e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 663071081   33 SLAFRDVSIDLSQEEWECLDAVQRDLYKDVMLENYSNLVSLG 74
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 34-73 2.88e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 81.44  E-value: 2.88e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 663071081  34 LAFRDVSIDLSQEEWECLDAVQRDLYKDVMLENYSNLVSL 73
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
357-797 1.99e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 1.99e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 357 KPYKCNECGKAFSHGSYLVQHQKIHTGEKPYEC--KECGKSFSFHAELARHRRIHTGEKPYECRecgKAFRLQTELTRH- 433
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSs 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 434 ---HRTHTGEKPYECKECGKAFICGYQLTLHLRTHTGEIPYECKECGKTFSSRYHLTQHYRIHTGEKPYICNECGKAFRL 510
Cdd:COG5048  109 slsSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 511 QGELTRHHRIHtcekpYECKECGKAFIHSNQfISHQRIHTSESTYICKECGKIFSRRYNLTQHFKIHTGEKPYICNECGK 590
Cdd:COG5048  189 SSNVSTSIPSS-----SENSPLSSSYSIPSS-SSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 591 AFRFQTELTQHHRIHTGE-------KPYKCTECGKAFIRSTHLTQH--HRIHTGE--KPYECTE--CGKTFSRHYHLTQH 657
Cdd:COG5048  263 SSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 658 HRGHTGEKPYIC-------------NECGNAFICSYRLTLHQRIHTGELPyeckECGKTFSRRYHLTQHFRLHTGEKPYS 724
Cdd:COG5048  343 ILLHTSISPAKEkllnssskfspllNNEPPQSLQQYKDLKNDKKSETLSN----SCIRNFKRDSNLSLHIITHLSFRPYN 418

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 663071081 725 CKecgnafrlqaeltrhhivhtgekpykCKECGKAFSVNSELTRHHRIHTGEKPYQCkECGKAFIRSDQLTLH 797
Cdd:COG5048  419 CK--------------------------NPPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
189-349 1.02e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 1.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 189 KSYECKECRKAFRQQSYLIQHLR--IHTGE--RPYKCME--CGKAFCRVGDLRVHHTIHAGERPYECKEC-------GKA 255
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 256 FRLHYHLTEHQRIHSGVKPYECKECGKAFSRVRD--LRVHQTIHAGERPYECK--ECGKAFRLHYQLTEHQRIHTGERPY 331
Cdd:COG5048  368 NNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDsnLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*...
gi 663071081 332 ECKVCGKtFRVQRHISQH 349
Cdd:COG5048  448 LCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
429-454 1.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.07e-03
                          10        20
                  ....*....|....*....|....*.
gi 663071081  429 ELTRHHRTHTGEKPYECKECGKAFIC 454
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
205-228 2.94e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.94e-03
                          10        20
                  ....*....|....*....|....
gi 663071081  205 YLIQHLRIHTGERPYKCMECGKAF 228
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
34-94 3.35e-34

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 124.63  E-value: 3.35e-34
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 663071081    34 LAFRDVSIDLSQEEWECLDAVQRDLYKDVMLENYSNLVSLGYTIPKPDVITLLEQEKEPWI 94
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 33-74 1.80e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.91  E-value: 1.80e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 663071081   33 SLAFRDVSIDLSQEEWECLDAVQRDLYKDVMLENYSNLVSLG 74
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 34-73 2.88e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 81.44  E-value: 2.88e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 663071081  34 LAFRDVSIDLSQEEWECLDAVQRDLYKDVMLENYSNLVSL 73
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
357-797 1.99e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 1.99e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 357 KPYKCNECGKAFSHGSYLVQHQKIHTGEKPYEC--KECGKSFSFHAELARHRRIHTGEKPYECRecgKAFRLQTELTRH- 433
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSs 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 434 ---HRTHTGEKPYECKECGKAFICGYQLTLHLRTHTGEIPYECKECGKTFSSRYHLTQHYRIHTGEKPYICNECGKAFRL 510
Cdd:COG5048  109 slsSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 511 QGELTRHHRIHtcekpYECKECGKAFIHSNQfISHQRIHTSESTYICKECGKIFSRRYNLTQHFKIHTGEKPYICNECGK 590
Cdd:COG5048  189 SSNVSTSIPSS-----SENSPLSSSYSIPSS-SSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 591 AFRFQTELTQHHRIHTGE-------KPYKCTECGKAFIRSTHLTQH--HRIHTGE--KPYECTE--CGKTFSRHYHLTQH 657
Cdd:COG5048  263 SSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 658 HRGHTGEKPYIC-------------NECGNAFICSYRLTLHQRIHTGELPyeckECGKTFSRRYHLTQHFRLHTGEKPYS 724
Cdd:COG5048  343 ILLHTSISPAKEkllnssskfspllNNEPPQSLQQYKDLKNDKKSETLSN----SCIRNFKRDSNLSLHIITHLSFRPYN 418

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 663071081 725 CKecgnafrlqaeltrhhivhtgekpykCKECGKAFSVNSELTRHHRIHTGEKPYQCkECGKAFIRSDQLTLH 797
Cdd:COG5048  419 CK--------------------------NPPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
245-631 2.33e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.19  E-value: 2.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 245 RPYECKECGKAFRLHYHLTEHQRIHSGVKPYEC--KECGKAFSRVRDLRVHQTIH---------AGERPYECK------- 306
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHhnnpsdlnsKSLPLSNSKassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 307 ECGKAFRLHYQLTEH---QRIHTGERP-------YECKVCGKTFRVQRHISQHQKIHTGVKPYkcNECGKAFSHGSYLVQ 376
Cdd:COG5048  112 SSSSNSNDNNLLSSHslpPSSRDPQLPdllsisnLRNNPLPGNNSSSVNTPQSNSLHPPLPAN--SLSKDPSSNLSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 377 HQKIHTGEKPYECKECGKSFSFHAELARHRRIHTgEKPYECRECGKAFRLQ-------TELTRHHRTHTGEKPYECKecG 449
Cdd:COG5048  190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSllsqspsSLSSSDSSSSASESPRSSL--P 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 450 KAFICGYQLTLHL-RTHTGEI-PYECKECGKTFSSRYHLTQHYR--IHTGE--KPYICNE--CGKAFRLQGELTRHHRIH 521
Cdd:COG5048  267 TASSQSSSPNESDsSSEKGFSlPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLH 346

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 522 TCEKPYECK--ECGKAFIHSN-----QFISHQRIHTSESTYIC--KECGKIFSRRYNLTQHFKIHTGEKP--YICNECGK 590
Cdd:COG5048  347 TSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSK 426

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 663071081 591 AFRFQTELTQHHRIHTgEKPYKCTECGKAFIRSTHLTQHHR 631
Cdd:COG5048  427 SFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
470-804 4.10e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 69.34  E-value: 4.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 470 PYECKECGKTFSSRYHLTQHYRIHTGEKPYICN--ECGKAFRLQGELTRHHRIHTCEKPYECKecgKAFIHSNQFISHQ- 546
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSSs 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 547 -RIHTSESTYICKECGKI--FSRRYNLTQHFKIHT---GEKPYICNecGKAFRFQTELTQHHRIHTGEKPYKCTECGKAF 620
Cdd:COG5048  110 lSSSSSNSNDNNLLSSHSlpPSSRDPQLPDLLSISnlrNNPLPGNN--SSSVNTPQSNSLHPPLPANSLSKDPSSNLSLL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 621 IrsthltqHHRIHTGEKPYECTECGKTFSRHYHLTQHHRGHTGEKPYICNECGNAFICSYRLTLHQRIHTGELPYECKEC 700
Cdd:COG5048  188 I-------SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 701 GKTF--SRRYHLTQHFRLHTGE-----KPYSCKECGNAFRLQAELTRH--HIVHTGE--KPYKCKE--CGKAFSVNSELT 767
Cdd:COG5048  261 PRSSlpTASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALK 340

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 663071081 768 RHHRIHTGEKPYQCKEC------GKAFIRSDQLTLHQRNHISE 804
Cdd:COG5048  341 RHILLHTSISPAKEKLLnssskfSPLLNNEPPQSLQQYKDLKN 383
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
413-809 1.63e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.41  E-value: 1.63e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 413 KPYECRECGKAFRLQTELTRHHRTHTGEKPYEC--KECGKAFICGYQLTLHLRTHTGEIPYEC-KECGKTFSSRYHLTQH 489
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 490 YRIHTGEKPYICNECGKAFRLQGELTRHHRIHTCEKPYECKECGKAFIHSNQFISHqrIHTSESTYICKECGKIFSRRYN 569
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSL--HPPLPANSLSKDPSSNLSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 570 LTqhfkIHTGEKPYICNECGKAFRFQTELTQHHRIHTGEKPYKCTECGKAFirstHLTQHHRIHTGEKPYECTECGKTFS 649
Cdd:COG5048  190 SN----VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLS----PKSLLSQSPSSLSSSDSSSSASESP 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 650 RHYHLTQHHRGHTG-----------EKPYICNECGNAFICSYRLTLHQR--IHTGE--LPYECKE--CGKTFSRRYHLTQ 712
Cdd:COG5048  262 RSSLPTASSQSSSPnesdsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKR 341

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 713 HFRLHTGEKPYSCKEC-------GNAFRLQAELTRHHIvhtGEKPYKCKECGKAFSVNSELTRH----HRI-HTGEKPYQ 780
Cdd:COG5048  342 HILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYK---DLKNDKKSETLSNSCIRNFKRDSnlslHIItHLSFRPYN 418

                        410       420       430
                 ....*....|....*....|....*....|.
gi 663071081 781 CK--ECGKAFIRSDQLTLHQRNHISEEVLCI 809
Cdd:COG5048  419 CKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
543-803 7.86e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 7.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 543 ISHQRIHTSES----TYICKECGKIFSRRYNLTQHFKIHTGEKPYICNECGKAFRFQT--ELTQHHRIHTGEKPYKC--- 613
Cdd:COG5048   18 STPKSTLKSLSnaprPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNsks 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 614 -------------TECGKAFIRSTHLTQHHRIHTGEKPYECTECGKTFSRHYHLTQHHRGHTGEKPYIC--------NEC 672
Cdd:COG5048   98 lplsnskasssslSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpanSLS 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 673 GNAFICSyRLTLHQRIHTGELPYECKECGKTFSRRYHLTQHFRLHTGEKPYSC--------------------------- 725
Cdd:COG5048  178 KDPSSNL-SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLttnsqlspksllsqspsslsssdssss 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 726 -KECGNAFRLQAELTRHHIVHTGE-------KPYKCKECGKAFSVNSELTRH--HRIHTGE--KPYQCKE--CGKAFIRS 791
Cdd:COG5048  257 aSESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRN 336

                        330
                 ....*....|..
gi 663071081 792 DQLTLHQRNHIS 803
Cdd:COG5048  337 DALKRHILLHTS 348
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
189-349 1.02e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 1.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 189 KSYECKECRKAFRQQSYLIQHLR--IHTGE--RPYKCME--CGKAFCRVGDLRVHHTIHAGERPYECKEC-------GKA 255
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663071081 256 FRLHYHLTEHQRIHSGVKPYECKECGKAFSRVRD--LRVHQTIHAGERPYECK--ECGKAFRLHYQLTEHQRIHTGERPY 331
Cdd:COG5048  368 NNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDsnLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*...
gi 663071081 332 ECKVCGKtFRVQRHISQH 349
Cdd:COG5048  448 LCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
429-454 1.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.07e-03
                          10        20
                  ....*....|....*....|....*.
gi 663071081  429 ELTRHHRTHTGEKPYECKECGKAFIC 454
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
765-790 1.18e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.18e-03
                          10        20
                  ....*....|....*....|....*.
gi 663071081  765 ELTRHHRIHTGEKPYQCKECGKAFIR 790
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
401-424 1.39e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.39e-03
                          10        20
                  ....*....|....*....|....
gi 663071081  401 ELARHRRIHTGEKPYECRECGKAF 424
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
373-397 1.73e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.73e-03
                          10        20
                  ....*....|....*....|....*
gi 663071081  373 YLVQHQKIHTGEKPYECKECGKSFS 397
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
625-650 1.93e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.93e-03
                          10        20
                  ....*....|....*....|....*.
gi 663071081  625 HLTQHHRIHTGEKPYECTECGKTFSR 650
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
597-622 2.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.05e-03
                          10        20
                  ....*....|....*....|....*.
gi 663071081  597 ELTQHHRIHTGEKPYKCTECGKAFIR 622
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
205-228 2.94e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.94e-03
                          10        20
                  ....*....|....*....|....
gi 663071081  205 YLIQHLRIHTGERPYKCMECGKAF 228
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
261-286 4.15e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.15e-03
                          10        20
                  ....*....|....*....|....*.
gi 663071081  261 HLTEHQRIHSGVKPYECKECGKAFSR 286
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
345-370 7.71e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.71e-03
                          10        20
                  ....*....|....*....|....*.
gi 663071081  345 HISQHQKIHTGVKPYKCNECGKAFSH 370
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
737-761 8.76e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.76e-03
                          10        20
                  ....*....|....*....|....*
gi 663071081  737 ELTRHHIVHTGEKPYKCKECGKAFS 761
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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