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Conserved domains on  [gi|663429552|ref|NP_001287698|]
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lysophospholipase-like protein 1 isoform b [Homo sapiens]

Protein Classification

alpha/beta hydrolase( domain architecture ID 10785415)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  19508187|12369917|37582413

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YpfH COG0400
Predicted esterase [General function prediction only];
13-179 4.28e-22

Predicted esterase [General function prediction only];


:

Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 88.43  E-value: 4.28e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429552  13 IVSPAGRHSASLIFLHGSGDSGQGLRMW--------------IKQVLNQ-DLTFQHIKIIYPTAPPSmfLFLGGFSMGGC 77
Cdd:COG0400   24 LAPELALPGAAVLAPRAPVPEGPGGRAWfdlsflegredeegLAAAAEAlAAFIDELEARYGIDPER--IVLAGFSQGAA 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429552  78 MAIHLAYRNHQDVAGVFALSSFLNKASAVYQALQKSNGvlPELFQCHGTADELVLHSWAEETNSMLKSLGVTTKFHSFPn 157
Cdd:COG0400  102 MALSLALRRPELLAGVVALSGYLPGEEALPAPEAALAG--TPVFLAHGTQDPVIPVERAREAAEALEAAGADVTYREYP- 178

                        170       180
                 ....*....|....*....|..
gi 663429552 158 VYHELSKTELDILKLWILTKLP 179
Cdd:COG0400  179 GGHEISPEELADARAWLAERLA 200
 
Name Accession Description Interval E-value
YpfH COG0400
Predicted esterase [General function prediction only];
13-179 4.28e-22

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 88.43  E-value: 4.28e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429552  13 IVSPAGRHSASLIFLHGSGDSGQGLRMW--------------IKQVLNQ-DLTFQHIKIIYPTAPPSmfLFLGGFSMGGC 77
Cdd:COG0400   24 LAPELALPGAAVLAPRAPVPEGPGGRAWfdlsflegredeegLAAAAEAlAAFIDELEARYGIDPER--IVLAGFSQGAA 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429552  78 MAIHLAYRNHQDVAGVFALSSFLNKASAVYQALQKSNGvlPELFQCHGTADELVLHSWAEETNSMLKSLGVTTKFHSFPn 157
Cdd:COG0400  102 MALSLALRRPELLAGVVALSGYLPGEEALPAPEAALAG--TPVFLAHGTQDPVIPVERAREAAEALEAAGADVTYREYP- 178

                        170       180
                 ....*....|....*....|..
gi 663429552 158 VYHELSKTELDILKLWILTKLP 179
Cdd:COG0400  179 GGHEISPEELADARAWLAERLA 200
Abhydrolase_2 pfam02230
Phospholipase/Carboxylesterase; This family consists of both phospholipases and ...
 13-171 1.01e-21

Phospholipase/Carboxylesterase; This family consists of both phospholipases and carboxylesterases with broad substrate specificity, and is structurally related to alpha/beta hydrolases pfam00561.


Pssm-ID: 396693 [Multi-domain]  Cd Length: 217  Bit Score: 87.82  E-value: 1.01e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429552   13 IVSPAGRHSASLIFLHGSGDSGQGlrmwIKQVLNQDLTFQHIKIIYPTAP--PSMFL----------------------- 67
Cdd:pfam02230   6 VVSPRDPAQATVIFLHGLGDSGHG----WADAAKTEAPLPNIKFIFPHGPeiPVTLNggmrmpawfdlvglspnakedea 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429552   68 --------------------------FLGGFSMGGCMAIHLAYRNHQDVAGVFALSSFLNKASAVYQALQKSNGVLPElF 121
Cdd:pfam02230  82 giknsaetieelidaeqkkgipssriIIGGFSQGAMLALYSALTLPLPLGGIVAFSGFLPLPTKFPSHPNLVTKKTPI-F 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 663429552  122 QCHGTADELVLHSWAEETNSMLKSLGVTTKFHSFPNVYHELSKTELDILK 171
Cdd:pfam02230 161 LIHGEEDPVVPLALGKLAKEYLKTSLNKVELKIYEGLAHSICGREMQDIK 210
 
Name Accession Description Interval E-value
YpfH COG0400
Predicted esterase [General function prediction only];
13-179 4.28e-22

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 88.43  E-value: 4.28e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429552  13 IVSPAGRHSASLIFLHGSGDSGQGLRMW--------------IKQVLNQ-DLTFQHIKIIYPTAPPSmfLFLGGFSMGGC 77
Cdd:COG0400   24 LAPELALPGAAVLAPRAPVPEGPGGRAWfdlsflegredeegLAAAAEAlAAFIDELEARYGIDPER--IVLAGFSQGAA 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429552  78 MAIHLAYRNHQDVAGVFALSSFLNKASAVYQALQKSNGvlPELFQCHGTADELVLHSWAEETNSMLKSLGVTTKFHSFPn 157
Cdd:COG0400  102 MALSLALRRPELLAGVVALSGYLPGEEALPAPEAALAG--TPVFLAHGTQDPVIPVERAREAAEALEAAGADVTYREYP- 178

                        170       180
                 ....*....|....*....|..
gi 663429552 158 VYHELSKTELDILKLWILTKLP 179
Cdd:COG0400  179 GGHEISPEELADARAWLAERLA 200
Abhydrolase_2 pfam02230
Phospholipase/Carboxylesterase; This family consists of both phospholipases and ...
 13-171 1.01e-21

Phospholipase/Carboxylesterase; This family consists of both phospholipases and carboxylesterases with broad substrate specificity, and is structurally related to alpha/beta hydrolases pfam00561.


Pssm-ID: 396693 [Multi-domain]  Cd Length: 217  Bit Score: 87.82  E-value: 1.01e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429552   13 IVSPAGRHSASLIFLHGSGDSGQGlrmwIKQVLNQDLTFQHIKIIYPTAP--PSMFL----------------------- 67
Cdd:pfam02230   6 VVSPRDPAQATVIFLHGLGDSGHG----WADAAKTEAPLPNIKFIFPHGPeiPVTLNggmrmpawfdlvglspnakedea 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429552   68 --------------------------FLGGFSMGGCMAIHLAYRNHQDVAGVFALSSFLNKASAVYQALQKSNGVLPElF 121
Cdd:pfam02230  82 giknsaetieelidaeqkkgipssriIIGGFSQGAMLALYSALTLPLPLGGIVAFSGFLPLPTKFPSHPNLVTKKTPI-F 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 663429552  122 QCHGTADELVLHSWAEETNSMLKSLGVTTKFHSFPNVYHELSKTELDILK 171
Cdd:pfam02230 161 LIHGEEDPVVPLALGKLAKEYLKTSLNKVELKIYEGLAHSICGREMQDIK 210
COG4099 COG4099
Predicted peptidase [General function prediction only];
24-160 3.86e-09

Predicted peptidase [General function prediction only];


Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 54.20  E-value: 3.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429552  24 LIFLHGSGDSGQ--------GLRMWIKQVLNQDltFQHIkIIYPTAPPSMF---------------------------LF 68
Cdd:COG4099   52 VLFLHGAGERGTdnekqlthGAPKFINPENQAK--FPAI-VLAPQCPEDDYwsdtkaldavlallddliaeyridpdrIY 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429552  69 LGGFSMGGCMAIHLAYRNHQDVAGVFALSSFLNKASAvyQALQKsngvLPeLFQCHGTADELVLHSWAEETNSMLKSLGV 148
Cdd:COG4099  129 LTGLSMGGYGTWDLAARYPDLFAAAVPICGGGDPANA--ANLKK----VP-VWIFHGAKDDVVPVEESRAMVEALKAAGA 201

                        170
                 ....*....|..
gi 663429552 149 TTKFHSFPNVYH 160
Cdd:COG4099  202 DVKYTEYPGVGH 213
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
67-166 2.23e-07

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 49.24  E-value: 2.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429552  67 LFLGGFSMGGCMAIHLAYRNHQ------DVAGVFALSSFLNKASAVYQALQKSNGVLPELFQ-----------------C 123
Cdd:COG1506   95 IGIYGHSYGGYMALLAAARHPDrfkaavALAGVSDLRSYYGTTREYTERLMGGPWEDPEAYAarsplayadklktplllI 174

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 663429552 124 HGTADELVLHSWAEETNSMLKSLGVTTKFHSFPNVYHELSKTE 166
Cdd:COG1506  175 HGEADDRVPPEQAERLYEALKKAGKPVELLVYPGEGHGFSGAG 217
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
67-160 3.28e-07

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 48.33  E-value: 3.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429552  67 LFLGGFSMGGCMAIHLAYRNHQD----VAGVFALSSFLN-KASAVYQALQKsngvLPELFQCHGTADELVLHSwaEETNS 141
Cdd:COG0657   88 IAVAGDSAGGHLAAALALRARDRggprPAAQVLIYPVLDlTASPLRADLAG----LPPTLIVTGEADPLVDES--EALAA 161

                         90
                 ....*....|....*....
gi 663429552 142 MLKSLGVTTKFHSFPNVYH 160
Cdd:COG0657  162 ALRAAGVPVELHVYPGGGH 180
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
1-162 1.38e-06

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 46.92  E-value: 1.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429552   1 MAAASGSVLQRCIVSPAGRHSASLIFLHGSGDSGQGLRMWIKQVLNQ-------DL--------------TFQH------ 53
Cdd:COG2267    8 LPTRDGLRLRGRRWRPAGSPRGTVVLVHGLGEHSGRYAELAEALAAAgyavlafDLrghgrsdgprghvdSFDDyvddlr 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429552  54 --IKII--YPTAPpsmfLFLGGFSMGGCMAIHLAYRNHQDVAGVFALSSFLNK------------ASAVYQALQKSNgvL 117
Cdd:COG2267   88 aaLDALraRPGLP----VVLLGHSMGGLIALLYAARYPDRVAGLVLLAPAYRAdpllgpsarwlrALRLAEALARID--V 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 663429552 118 PELFqCHGTADELVLhswAEETNSMLKSLGVTTKFHSFPNVYHEL 162
Cdd:COG2267  162 PVLV-LHGGADRVVP---PEAARRLAARLSPDVELVLLPGARHEL 202
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 29-98 1.80e-05

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 43.74  E-value: 1.80e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 663429552   29 GSGDSGqGLRMWIK--QVLNQDLT--FQHIKIIYPTAPpsmfLFLGGFSMGGCMAIHLAYRNHQDVAGVfALSS 98
Cdd:pfam12146  41 GHGRSD-GKRGHVPsfDDYVDDLDtfVDKIREEHPGLP----LFLLGHSMGGLIAALYALRYPDKVDGL-ILSA 108
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
71-160 4.90e-05

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 42.26  E-value: 4.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429552  71 GFSMGGCMAIHLAyRNHQDVAGVFALSSFLNKASAVyQALQKSNGvlPELFqCHGTADELVLHSWAEETNSMLKSLGVTT 150
Cdd:COG0412  115 GFCFGGGLALLAA-ARGPDLAAAVSFYGGLPADDLL-DLAARIKA--PVLL-LYGEKDPLVPPEQVAALEAALAAAGVDV 189

                         90
                 ....*....|
gi 663429552 151 KFHSFPNVYH 160
Cdd:COG0412  190 ELHVYPGAGH 199
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
68-101 8.52e-05

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 41.85  E-value: 8.52e-05
                         10        20        30
                 ....*....|....*....|....*....|....
gi 663429552  68 FLGGFSMGGCMAIHLAYRnHQDVAGVFALSSFLN 101
Cdd:COG1647   87 IVIGLSMGGLLALLLAAR-YPDVAGLVLLSPALK 119
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
58-156 1.38e-04

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 41.38  E-value: 1.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429552  58 YPTAPPSMFLFLGGFSMGGCMAIHLAYRNHQDVAGVFALSSFLNKASAVYQALQKSNgVLPE--------LFQCHGTADE 129
Cdd:COG2382  189 YRVSADPEHRAIAGLSMGGLAALYAALRHPDLFGYVGSFSGSFWWPPGDADRGGWAE-LLAAgapkkplrFYLDVGTEDD 267

                         90       100
                 ....*....|....*....|....*..
gi 663429552 130 LVLHswAEETNSMLKSLGVTTKFHSFP 156
Cdd:COG2382  268 LLEA--NRALAAALKAKGYDVEYREFP 292
Abhydrolase_11 pfam20408
Alpha/beta hydrolase domain; This entry represents a protein that belongs to the alpha/beta ...
 61-96 2.37e-03

Alpha/beta hydrolase domain; This entry represents a protein that belongs to the alpha/beta hydrolase superfamily. Although proteins in this family are uncharacterized they are likely to have an enzymatic activity.


Pssm-ID: 466557 [Multi-domain]  Cd Length: 193  Bit Score: 37.18  E-value: 2.37e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 663429552   61 APPSMFLFLGGFSMGGCMAIHLAyrNHQDVAGVFAL 96
Cdd:pfam20408  72 RGPDLPLFIGGKSMGGRVASLLA--DDSGVKGVIAL 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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