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Conserved domains on  [gi|665505952|ref|NP_001287839|]
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rho GTPase-activating protein SYDE1 isoform 2 [Homo sapiens]

Protein Classification

Rho GTPase-activating protein( domain architecture ID 1569)

Rho GTPase-activating protein for Rho/Rac/Cdc42-like small GTPases that act as molecular switches, active in their GTP-bound form but inactive when bound to GDP

CATH:  1.10.555.10
Gene Ontology:  GO:0007165|GO:0005096
PubMed:  17222083|12480336
SCOP:  4001255

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP super family cl02570
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 329-534 1.35e-106

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


The actual alignment was detected with superfamily member cd04379:

Pssm-ID: 470621  Cd Length: 207  Bit Score: 321.72  E-value: 1.35e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 329 FGLPLPLLVERERPPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDINVITGIL 408
Cdd:cd04379    1 FGVPLSRLVEREGESRDVPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDAFERNSAAVELSEELYPDINVITGVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 409 KDYLRELPTPLITQPLYKVVLEAMARDPPNRVPPTTEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAV 488
Cdd:cd04379   81 KDYLRELPEPLITPQLYEMVLEALAVALPNDVQTNTHLTLSIIDCLPLSAKATLLLLLDHLSLVLSNSERNKMTPQNLAV 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 665505952 489 CFGPVLLPARQAPTRPRAR-SSGPGLASAVDFKHHIEVLHYLLQSWP 534
Cdd:cd04379  161 CFGPVLMFCSQEFSRYGISpTSKMAAVSTVDFKQHIEVLHYLLQIWP 207
 
Name Accession Description Interval E-value
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 329-534 1.35e-106

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 321.72  E-value: 1.35e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 329 FGLPLPLLVERERPPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDINVITGIL 408
Cdd:cd04379    1 FGVPLSRLVEREGESRDVPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDAFERNSAAVELSEELYPDINVITGVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 409 KDYLRELPTPLITQPLYKVVLEAMARDPPNRVPPTTEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAV 488
Cdd:cd04379   81 KDYLRELPEPLITPQLYEMVLEALAVALPNDVQTNTHLTLSIIDCLPLSAKATLLLLLDHLSLVLSNSERNKMTPQNLAV 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 665505952 489 CFGPVLLPARQAPTRPRAR-SSGPGLASAVDFKHHIEVLHYLLQSWP 534
Cdd:cd04379  161 CFGPVLMFCSQEFSRYGISpTSKMAAVSTVDFKQHIEVLHYLLQIWP 207
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 344-533 1.75e-45

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 159.74  E-value: 1.75e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952   344 GQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDlyPDINVITGILKDYLRELPTPLITQP 423
Cdd:smart00324   1 KPIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLSE--YDVHDVAGLLKLFLRELPEPLITYE 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952   424 LYKVVLEAMARDPPNRVPpttEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLLparqaptr 503
Cdd:smart00324  79 LYEEFIEAAKLEDETERL---RALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLL-------- 147

                          170       180       190
                   ....*....|....*....|....*....|
gi 665505952   504 praRSSGPGLASAVDFKHHIEVLHYLLQSW 533
Cdd:smart00324 148 ---RPPDGEVASLKDIRHQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 347-499 1.74e-37

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 136.52  E-value: 1.74e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952  347 PLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDlyPDINVITGILKDYLRELPTPLITQPLYK 426
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLDLEE--EDVHVVASLLKLFLRELPEPLLTFELYE 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665505952  427 VVLEAMARDPP-NRVPPTTEgtrgLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLLPARQ 499
Cdd:pfam00620  79 EFIEAAKLPDEeERLEALRE----LLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
 
Name Accession Description Interval E-value
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 329-534 1.35e-106

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 321.72  E-value: 1.35e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 329 FGLPLPLLVERERPPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDINVITGIL 408
Cdd:cd04379    1 FGVPLSRLVEREGESRDVPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDAFERNSAAVELSEELYPDINVITGVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 409 KDYLRELPTPLITQPLYKVVLEAMARDPPNRVPPTTEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAV 488
Cdd:cd04379   81 KDYLRELPEPLITPQLYEMVLEALAVALPNDVQTNTHLTLSIIDCLPLSAKATLLLLLDHLSLVLSNSERNKMTPQNLAV 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 665505952 489 CFGPVLLPARQAPTRPRAR-SSGPGLASAVDFKHHIEVLHYLLQSWP 534
Cdd:cd04379  161 CFGPVLMFCSQEFSRYGISpTSKMAAVSTVDFKQHIEVLHYLLQIWP 207
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 344-533 1.75e-45

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 159.74  E-value: 1.75e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952   344 GQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDlyPDINVITGILKDYLRELPTPLITQP 423
Cdd:smart00324   1 KPIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLSE--YDVHDVAGLLKLFLRELPEPLITYE 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952   424 LYKVVLEAMARDPPNRVPpttEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLLparqaptr 503
Cdd:smart00324  79 LYEEFIEAAKLEDETERL---RALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLL-------- 147

                          170       180       190
                   ....*....|....*....|....*....|
gi 665505952   504 praRSSGPGLASAVDFKHHIEVLHYLLQSW 533
Cdd:smart00324 148 ---RPPDGEVASLKDIRHQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 347-499 1.74e-37

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 136.52  E-value: 1.74e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952  347 PLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDlyPDINVITGILKDYLRELPTPLITQPLYK 426
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLDLEE--EDVHVVASLLKLFLRELPEPLLTFELYE 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665505952  427 VVLEAMARDPP-NRVPPTTEgtrgLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLLPARQ 499
Cdd:pfam00620  79 EFIEAAKLPDEeERLEALRE----LLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 347-531 5.71e-37

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 135.89  E-value: 5.71e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 347 PLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDlypDINVITGILKDYLRELPTPLITQPLYK 426
Cdd:cd00159    1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRGEDIDDLEDY---DVHDVASLLKLYLRELPEPLIPFELYD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 427 VVLEAMARDPPNRvppTTEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLLparqaptrpra 506
Cdd:cd00159   78 EFIELAKIEDEEE---RIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLL----------- 143

                        170       180
                 ....*....|....*....|....*
gi 665505952 507 RSSGPGLASAVDFKHHIEVLHYLLQ 531
Cdd:cd00159  144 RPPDSDDELLEDIKKLNEIVEFLIE 168
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 329-497 1.77e-28

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 112.50  E-value: 1.77e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 329 FGLPLPLLVERERppGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCL--SEDLYPDINVITG 406
Cdd:cd04398    1 FGVPLEDLILREG--DNVPNIVYQCIQAIENFGLNLEGIYRLSGNVSRVNKLKELFDKDPLNVLLisPEDYESDIHSVAS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 407 ILKDYLRELPTPLITQPLYKVVLEA-MARDPPNRvpptTEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQN 485
Cdd:cd04398   79 LLKLFFRELPEPLLTKALSREFIEAaKIEDESRR----RDALHGLINDLPDANYATLRALMFHLARIKEHESVNRMSVNN 154

                        170
                 ....*....|..
gi 665505952 486 LAVCFGPVLLPA 497
Cdd:cd04398  155 LAIIWGPTLMNA 166
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 329-531 3.24e-28

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 111.84  E-value: 3.24e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 329 FGLPLPLLVERErpPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDINVITGIL 408
Cdd:cd04372    1 YGCDLTTLVKAH--NTQRPMVVDMCIREIEARGLQSEGLYRVSGFAEEIEDVKMAFDRDGEKADISATVYPDINVITGAL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 409 KDYLRELPTPLITQPLYKVVLEAMA-RDPPNRVppttEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLA 487
Cdd:cd04372   79 KLYFRDLPIPVITYDTYPKFIDAAKiSNPDERL----EAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKDNKMNAENLG 154

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 665505952 488 VCFGPVLLPARQAPTrprarssgpgLASAVDFKHHIEVLHYLLQ 531
Cdd:cd04372  155 IVFGPTLMRPPEDSA----------LTTLNDMRYQILIVQLLIT 188
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 329-495 6.88e-28

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 110.94  E-value: 6.88e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 329 FGLPLPLLVERERppGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAaVCLSEDLYPDINVITGIL 408
Cdd:cd04403    1 FGCHLEALCQREN--STVPKFVRLCIEAVEKRGLDVDGIYRVSGNLAVIQKLRFAVDHDEK-LDLDDSKWEDIHVITGAL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 409 KDYLRELPTPLITQPLYKVVLEAMAR-DPPNRVppttEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLA 487
Cdd:cd04403   78 KLFFRELPEPLFPYSLFNDFVAAIKLsDYEQRV----SAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKNRMTTQNLA 153


                 ....*...
gi 665505952 488 VCFGPVLL 495
Cdd:cd04403  154 IVFGPTLL 161
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 329-531 2.78e-27

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 109.25  E-value: 2.78e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 329 FGLPLPLLVERERppGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDS--AAVCLSEdlyPDINVITG 406
Cdd:cd04387    1 FGVKISTVTKRER--SKVPYIVRQCVEEVERRGMEEVGIYRISGVATDIQALKAAFDTNNkdVSVMLSE---MDVNAIAG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 407 ILKDYLRELPTPLITQPLYKVVLEAMA-RDPPNRvpptTEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQN 485
Cdd:cd04387   76 TLKLYFRELPEPLFTDELYPNFAEGIAlSDPVAK----ESCMLNLLLSLPDPNLVTFLFLLHHLKRVAEREEVNKMSLHN 151

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 665505952 486 LAVCFGPVLLpaRQAPTRPRARSSGPGLASAVDFKHHIEVLHYLLQ 531
Cdd:cd04387  152 LATVFGPTLL--RPSEKESKIPTNTMTDSWSLEVMSQVQVLLYFLQ 195
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 328-532 1.11e-26

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 107.49  E-value: 1.11e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 328 VFGLPLpllveRERPPGQ----VPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDINV 403
Cdd:cd04395    1 TFGVPL-----DDCPPSSenpyVPLIVEVCCNIVEARGLETVGIYRVPGNNAAISALQEELNRGGFDIDLQDPRWRDVNV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 404 ITGILKDYLRELPTPLITQPLYKVVLEA-MARDPPNRVppttEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMT 482
Cdd:cd04395   76 VSSLLKSFFRKLPEPLFTNELYPDFIEAnRIEDPVERL----KELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKME 151

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 665505952 483 PQNLAVCFGPVLLparqaptrpraRSSGPGLASAV-DFKHHIEVLHYLLQS 532
Cdd:cd04395  152 PRNLAIVFGPTLV-----------RTSDDNMETMVtHMPDQCKIVETLIQH 191
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 329-495 1.47e-25

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 104.06  E-value: 1.47e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 329 FGLPLPLLVERERPpgqVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLsEDlYPdINVITGIL 408
Cdd:cd04377    1 FGVSLSSLTSEDRS---VPLVLEKLLEHIEMHGLYTEGIYRKSGSANKIKELRQGLDTDPDSVNL-ED-YP-IHVITSVL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 409 KDYLRELPTPLITQPLYKVVLEAMA-RDPPNRVppttEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLA 487
Cdd:cd04377   75 KQWLRELPEPLMTFELYENFLRAMElEEKQERV----RALYSVLEQLPRANLNTLERLIFHLVRVALQEEVNRMSANALA 150


                 ....*...
gi 665505952 488 VCFGPVLL 495
Cdd:cd04377  151 IVFAPCIL 158
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 343-531 1.77e-25

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 104.43  E-value: 1.77e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 343 PGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEdLYPdiNVITGILKDYLRELPTPLITQ 422
Cdd:cd04378   13 PDEVPFIIKKCTSEIENRALGVQGIYRVSGSKARVEKLCQAFENGKDLVELSE-LSP--HDISSVLKLFLRQLPEPLILF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 423 PLYKVVLeAMA----RDPPNRVPPTTEGT--------RGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCF 490
Cdd:cd04378   90 RLYNDFI-ALAkeiqRDTEEDKAPNTPIEvnriirklKDLLRQLPASNYNTLQHLIAHLYRVAEQFEENKMSPNNLGIVF 168

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 665505952 491 GPVLLparqaptRPRARSSGPGLASAVDFKHHIEVLHYLLQ 531
Cdd:cd04378  169 GPTLI-------RPRPGDADVSLSSLVDYGYQARLVEFLIT 202
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 334-495 3.67e-25

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 102.77  E-value: 3.67e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 334 PLLVERERPPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYpDINVITGILKDYLR 413
Cdd:cd04385    3 PALEDQQLTDNDIPVIVDKCIDFITQHGLMSEGIYRKNGKNSSVKKLLEAFRKDARSVQLREGEY-TVHDVADVLKRFLR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 414 ELPTPLITQPLYKVVLEAMA-RDPPNRVppttEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGP 492
Cdd:cd04385   82 DLPDPLLTSELHAEWIEAAElENKDERI----ARYKELIRRLPPINRATLKVLIGHLYRVQKHSDENQMSVHNLALVFGP 157


                 ...
gi 665505952 493 VLL 495
Cdd:cd04385  158 TLF 160
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 329-500 3.01e-24

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 100.49  E-value: 3.01e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 329 FGLPLPLLVERERPPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERdsaAVCLSEDLYPDINVITGIL 408
Cdd:cd04404    6 FGVSLQFLKEKNPEQEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNM---GEPVDFDQYEDVHLPAVIL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 409 KDYLRELPTPLITQPLYKVVLEAMARDPPNRVPPTTEgtrgLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAV 488
Cdd:cd04404   83 KTFLRELPEPLLTFDLYDDIVGFLNVDKEERVERVKQ----LLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAV 158

                        170
                 ....*....|..
gi 665505952 489 CFGPVLLPARQA 500
Cdd:cd04404  159 VFGPNLLWAKDA 170
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 329-495 1.80e-22

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 95.44  E-value: 1.80e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 329 FGLPLPLLVERERPpgqVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEdlYPdINVITGIL 408
Cdd:cd04407    1 FGVRVGSLTSNKTS---VPIVLEKLLEHVEMHGLYTEGIYRKSGSANRMKELHQLLQADPENVKLEN--YP-IHAITGLL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 409 KDYLRELPTPLITQPLYKVVLEAMardppnRVPPTTEGTRGL---LSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQN 485
Cdd:cd04407   75 KQWLRELPEPLMTFAQYNDFLRAV------ELPEKQEQLQAIyrvLEQLPTANHNTLERLIFHLVKVALEEDVNRMSPNA 148

                        170
                 ....*....|
gi 665505952 486 LAVCFGPVLL 495
Cdd:cd04407  149 LAIVFAPCLL 158
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 328-494 1.37e-21

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 92.81  E-value: 1.37e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 328 VFGLPLPLLVERERPPGQ---VPLIIQKCVGQIE-RRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDINV 403
Cdd:cd04400    1 IFGSPLEEAVELSSHKYNgrdLPSVVYRCIEYLDkNRAIYEEGIFRLSGSASVIKQLKERFNTEYDVDLFSSSLYPDVHT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 404 ITGILKDYLRELPTPLITQPLYKvVLEAMARDPPNRVPPTTEgTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTP 483
Cdd:cd04400   81 VAGLLKLYLRELPTLILGGELHN-DFKRLVEENHDRSQRALE-LKDLVSQLPQANYDLLYVLFSFLRKIIEHSDVNKMNL 158

                        170
                 ....*....|.
gi 665505952 484 QNLAVCFGPVL 494
Cdd:cd04400  159 RNVCIVFSPTL 169
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 341-530 1.33e-20

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 90.64  E-value: 1.33e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 341 RPPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEdLYPdiNVITGILKDYLRELPTPLI 420
Cdd:cd04409   11 KSPDGIPFIIKKCTSEIESRALCLKGIYRVNGAKSRVEKLCQAFENGKDLVELSE-LSP--HDISNVLKLYLRQLPEPLI 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 421 TQPLYKVVL----EAMARDPPNRVPPTTEG---------------TRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRM 481
Cdd:cd04409   88 LFRLYNEFIglakESQHVNETQEAKKNSDKkwpnmctelnrillkSKDLLRQLPAPNYNTLQFLIVHLHRVSEQAEENKM 167

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 665505952 482 TPQNLAVCFGPVLLparqaptRPRARSSGPGLASAVDFKHHIEVLHYLL 530
Cdd:cd04409  168 SASNLGIIFGPTLI-------RPRPTDATVSLSSLVDYPHQARLVELLI 209
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 343-495 4.57e-20

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 88.72  E-value: 4.57e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 343 PGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDinvITGILKDYLRELPTPLITQ 422
Cdd:cd04408   13 PEEVPFVVVRCTAEIENRALGVQGIYRISGSKARVEKLCQAFENGRDLVDLSGHSPHD---ITSVLKHFLKELPEPVLPF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 423 PLY-------KVVLEAMARDP--PNRVPPTTEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPV 493
Cdd:cd04408   90 QLYddfialaKELQRDSEKAAesPSIVENIIRSLKELLGRLPVSNYNTLRHLMAHLYRVAERFEDNKMSPNNLGIVFGPT 169


                 ..
gi 665505952 494 LL 495
Cdd:cd04408  170 LL 171
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 325-498 1.75e-19

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 87.13  E-value: 1.75e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 325 EPRVFGLPLP--LLVERERppgqVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFerDSAAVCLSEDL-YPDI 401
Cdd:cd04386    1 EKPVFGTPLEehLKRTGRE----IALPIEACVMCLLETGMNEEGLFRVGGGASKLKRLKAAL--DAGTFSLPLDEfYSDP 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 402 NVITGILKDYLRELPTPLITQPLYKVVLEAMAR-DPPNRVppttEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNR 480
Cdd:cd04386   75 HAVASALKSYLRELPDPLLTYNLYEDWVQAANKpDEDERL----QAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDENK 150

                        170
                 ....*....|....*...
gi 665505952 481 MTPQNLAVCFGPVLLPAR 498
Cdd:cd04386  151 MSPSNIAIVLAPNLLWAK 168
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 346-494 1.97e-19

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 86.58  E-value: 1.97e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 346 VPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEdlyPDINVITGILKDYLRELPTPLITQPLY 425
Cdd:cd04382   17 IPALIVHCVNEIEARGLTEEGLYRVSGSEREVKALKEKFLRGKTVPNLSK---VDIHVICGCLKDFLRSLKEPLITFALW 93

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 426 KVVLEAM-ARDPPNRVPPTTEgtrgLLSCLPDVERATLTLLLDHLRLVSSFHAyNRMTPQNLAVCFGPVL 494
Cdd:cd04382   94 KEFMEAAeILDEDNSRAALYQ----AISELPQPNRDTLAFLILHLQRVAQSPE-CKMDINNLARVFGPTI 158
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 336-496 3.43e-19

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 85.94  E-value: 3.43e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 336 LVERERPPGQ-VPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERdsaavclSEDLYP------DINVITGIL 408
Cdd:cd04383    7 LEEYIQDSGQaIPLVVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNAFER-------GEDPLAddqndhDINSVAGVL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 409 KDYLRELPTPLITQPLYKVVLE-AMARDPPNRVPPTtegtRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLA 487
Cdd:cd04383   80 KLYFRGLENPLFPKERFEDLMScVKLENPTERVHQI----REILSTLPRSVIIVMRYLFAFLNHLSQFSDENMMDPYNLA 155


                 ....*....
gi 665505952 488 VCFGPVLLP 496
Cdd:cd04383  156 ICFGPTLMP 164
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 329-496 6.05e-19

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 85.20  E-value: 6.05e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 329 FGLPLPLLVERERPpgqVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLypDINVITGIL 408
Cdd:cd04373    1 FGVPLANVVTSEKP---IPIFLEKCVEFIEATGLETEGIYRVSGNKTHLDSLQKQFDQDHNLDLVSKDF--TVNAVAGAL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 409 KDYLRELPTPLITQPLYKVVLEAMA-RDPPNRVppttEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLA 487
Cdd:cd04373   76 KSFFSELPDPLIPYSMHLELVEAAKiNDREQRL----HALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNLMTSENLS 151


                 ....*....
gi 665505952 488 VCFGPVLLP 496
Cdd:cd04373  152 ICFWPTLMR 160
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 349-499 1.28e-18

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 84.75  E-value: 1.28e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 349 IIQKCVGQIERRGLRVVGLYRLCG-SAAVKKELRDAFERDSAAvCLSEDLYP---DINVITGILKDYLRELPTPLITQPL 424
Cdd:cd04374   31 FVRKCIEAVETRGINEQGLYRVVGvNSKVQKLLSLGLDPKTST-PGDVDLDNsewEIKTITSALKTYLRNLPEPLMTYEL 109

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665505952 425 YKVVLEAMARDPPN-RVppttEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLLPARQ 499
Cdd:cd04374  110 HNDFINAAKSENLEsRV----NAIHSLVHKLPEKNREMLELLIKHLTNVSDHSKKNLMTVSNLGVVFGPTLLRPQE 181
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 327-499 1.07e-17

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 81.78  E-value: 1.07e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 327 RVFGLPLPLLVERErppGQ-VPLIIQKCVGQIERRGLrVVGLYRLCGSAAVKKELRDAFerDSAAVC-LSEDLY-PDINV 403
Cdd:cd04384    1 RVFGCDLTEHLLNS---GQdVPQVLKSCTEFIEKHGI-VDGIYRLSGIASNIQRLRHEF--DSEQIPdLTKDVYiQDIHS 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 404 ITGILKDYLRELPTPLITQPLYKVVLEAMARDPPNRvppTTEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTP 483
Cdd:cd04384   75 VSSLCKLYFRELPNPLLTYQLYEKFSEAVSAASDEE---RLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHA 151

                        170
                 ....*....|....*.
gi 665505952 484 QNLAVCFGPVLLPARQ 499
Cdd:cd04384  152 KNLAIVWAPNLLRSKQ 167
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 328-498 1.33e-16

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 79.31  E-value: 1.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 328 VFGLPLPLLVERER--PPG-QVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDsaavcLSEDLYPDINV- 403
Cdd:cd04391    1 LFGVPLSTLLERDQkkVPGsKVPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEAK-----FYEGTFLWDQVk 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 404 ---ITGILKDYLRELPTPLITQPLYKvVLEAMARDPpnRVPPTTEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNR 480
Cdd:cd04391   76 qhdAASLLKLFIRELPQPLLTVEYLP-AFYSVQGLP--SKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNK 152

                        170
                 ....*....|....*...
gi 665505952 481 MTPQNLAVCFGPVLLPAR 498
Cdd:cd04391  153 MNLWNVAMIMAPNLFPPR 170
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 345-533 1.47e-16

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 78.64  E-value: 1.47e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 345 QVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERdSAAVCLSEDLYPdiNVITGILKDYLRELPTPLITQPL 424
Cdd:cd04376    8 QVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDR-GIDVVLDENHSV--HDVAALLKEFFRDMPDPLLPREL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 425 YKVVLEAMARDPPNR-----------VPPTTEGTRGLLSCLPDVERATLTLLLDHLRLVSSfhayNRMTPQNLAVCFGPV 493
Cdd:cd04376   85 YTAFIGTALLEPDEQlealqlliyllPPCNCDTLHRLLKFLHTVAEHAADSIDEDGQEVSG----NKMTSLNLATIFGPN 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 665505952 494 LLPArqapTRPRARSSGPGLASAVDFKHHIEVLHYLLQSW 533
Cdd:cd04376  161 LLHK----QKSGEREFVQASLRIEESTAIINVVQTMIDNY 196
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 328-495 1.57e-16

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 78.64  E-value: 1.57e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 328 VFGLPLPLLVERERPPGQ--VPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAF---ERDSAavclseDLYPDIN 402
Cdd:cd04390    2 VFGQRLEDTVAYERKFGPrlVPILVEQCVDFIREHGLKEEGLFRLPGQANLVKQLQDAFdagERPSF------DSDTDVH 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 403 VITGILKDYLRELPTPLITQPLYKVVLEAMARDPPNRVPPTTEGTRgLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMT 482
Cdd:cd04390   76 TVASLLKLYLRELPEPVIPWAQYEDFLSCAQLLSKDEEKGLGELMK-QVSILPKVNYNLLSYICRFLDEVQSNSSVNKMS 154

                        170
                 ....*....|...
gi 665505952 483 PQNLAVCFGPVLL 495
Cdd:cd04390  155 VQNLATVFGPNIL 167
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 329-495 2.54e-16

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 77.73  E-value: 2.54e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 329 FGLPLPLLVERERppgQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLseDLYpDINVITGIL 408
Cdd:cd04406    1 FGVELSRLTSEDR---SVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDANSVNL--DDY-NIHVIASVF 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 409 KDYLRELPTPLITQPLYKVVLEAMArdppnrVPPTTEGTRGLLSCLPDVER---ATLTLLLDHLRLVSSFHAYNRMTPQN 485
Cdd:cd04406   75 KQWLRDLPNPLMTFELYEEFLRAMG------LQERRETVRGVYSVIDQLSRthlNTLERLIFHLVRIALQEETNRMSANA 148

                        170
                 ....*....|
gi 665505952 486 LAVCFGPVLL 495
Cdd:cd04406  149 LAIVFAPCIL 158
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 327-492 1.40e-15

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 75.58  E-value: 1.40e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 327 RVFGLPLPLLVERERPPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFErDSAAVCLSEDlyPDINVITG 406
Cdd:cd04393    1 KVFGVPLQELQQAGQPENGVPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLD-SGEEVDLSKE--ADVCSAAS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 407 ILKDYLRELPTPLITQPLYKVVLEAMARDPPNRVppTTEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNL 486
Cdd:cd04393   78 LLRLFLQELPEGLIPASLQIRLMQLYQDYNGEDE--FGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHENRMTAENL 155


                 ....*.
gi 665505952 487 AVCFGP 492
Cdd:cd04393  156 AAVFGP 161
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 329-494 1.57e-13

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 69.39  E-value: 1.57e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 329 FGLPLPLLVERERPPG--QVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAaVCLSEdlYpDINVITG 406
Cdd:cd04381    1 FGASLSLAVERSRCHDgiDLPLVFRECIDYVEKHGMKCEGIYKVSGIKSKVDELKAAYNRRES-PNLEE--Y-EPPTVAS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 407 ILKDYLRELPTPLITQPLYKVVLEAMARdppnrvppTTEGTR-----GLLSCLPDVERATLTLLLDHLRLVSSFHAYNRM 481
Cdd:cd04381   77 LLKQYLRELPEPLLTKELMPRFEEACGR--------PTEAEReqelqRLLKELPECNRLLLAWLIVHMDHVIAQELETKM 148

                        170
                 ....*....|...
gi 665505952 482 TPQNLAVCFGPVL 494
Cdd:cd04381  149 NIQNISIVLSPTV 161
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 328-513 1.77e-13

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 70.14  E-value: 1.77e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 328 VFGLPLPLLVERErppGQ-VPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDInviTG 406
Cdd:cd04375    4 VFGVPLLVNLQRT---GQpLPRSIQQAMRWLRNNALDQVGLFRKSGVKSRIQKLRSMIESSTDNVNYDGQQAYDV---AD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 407 ILKDYLRELPTPLITQPLYKVVLeAMARDPPNRVPPTTEGTRGLLscLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNL 486
Cdd:cd04375   78 MLKQYFRDLPEPLLTNKLSETFI-AIFQYVPKEQRLEAVQCAILL--LPDENREVLQTLLYFLSDVAANSQENQMTATNL 154

                        170       180       190
                 ....*....|....*....|....*....|...
gi 665505952 487 AVCFGPVLLPARQ------APTRPRARSSGPGL 513
Cdd:cd04375  155 AVCLAPSLFHLNTsrrensSPARRMQRKKSLGK 187
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 328-496 7.14e-11

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 62.10  E-value: 7.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 328 VFGLPLPLLVERERPP-GQVPLIIQKCVGQIERRgLRVVGLYRLCGSAAVKKELRDAFerDSAAVCLSEDLYPDInviTG 406
Cdd:cd04394    1 VFGVPLHSLPHSTVPEyGNVPKFLVDACTFLLDH-LSTEGLFRKSGSVVRQKELKAKL--EGGEACLSSALPCDV---AG 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 407 ILKDYLRELPTPLITQPLYKVVLEAmardppNRVPPTTEGTRG--LLSC-LPDVERATLTLLLDHLRLVSSFHAYNRMTP 483
Cdd:cd04394   75 LLKQFFRELPEPLLPYDLHEALLKA------QELPTDEERKSAtlLLTClLPDEHVNTLRYFFSFLYDVAQRCSENKMDS 148

                        170
                 ....*....|...
gi 665505952 484 QNLAVCFGPVLLP 496
Cdd:cd04394  149 SNLAVIFAPNLFQ 161
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 329-495 7.62e-11

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 61.93  E-value: 7.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 329 FGLPLPLLVererPPGQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVClseDLYPdINVITGIL 408
Cdd:cd04402    2 FGQPLSNIC----EDDNLPKPILDMLSLLYQKGPSTEGIFRRSANAKACKELKEKLNSGVEVDL---KAEP-VLLLASVL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 409 KDYLRELPTPLITQPLYKVVLEAMARDPPNRVpptTEGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAV 488
Cdd:cd04402   74 KDFLRNIPGSLLSSDLYEEWMSALDQENEEEK---IAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAV 150


                 ....*..
gi 665505952 489 CFGPVLL 495
Cdd:cd04402  151 CIAPSLL 157
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 329-530 1.91e-10

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 61.23  E-value: 1.91e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 329 FGLPLPLLVERERP-------PG--QVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVclsEDLYP 399
Cdd:cd04397    1 FGVPLEILVEKFGAdstlgvgPGklRIPALIDDIISAMRQMDMSVEGVFRKNGNIRRLKELTEEIDKNPTEV---PDLSK 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 400 DINV-ITGILKDYLRELPTPLITQPLYKVVLEAmardppNRVPPTTEGTRGL---LSCLPDVERATLTLLLDHLRLVSSF 475
Cdd:cd04397   78 ENPVqLAALLKKFLRELPDPLLTFKLYRLWISS------QKIEDEEERKRVLhlvYCLLPKYHRDTMEVLFSFLKWVSSF 151

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665505952 476 HAY-----NRMTPQNLAVCFGPVLLparqaptRPRARSSGPG----LAsavdfkhhIEVLHYLL 530
Cdd:cd04397  152 SHIdeetgSKMDIHNLATVITPNIL-------YSKTDNPNTGdeyfLA--------IEAVNYLI 200
RhoGAP_p85 cd04388
RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 333-556 2.98e-07

RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) homology (BH) domain. Class IA PI3Ks are heterodimers, containing a regulatory subunit (p85) and a catalytic subunit (p110) and are activated by growth factor receptor tyrosine kinases (RTKs); this activation is mediated by the p85 subunit. p85 isoforms, alpha and beta, contain a C-terminal p110-binding domain flanked by two SH2 domains, an N-terminal SH3 domain, and a RhoGAP domain flanked by two proline-rich regions. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239853  Cd Length: 200  Bit Score: 51.41  E-value: 2.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 333 LPLLVERERPPGQVPLIIQKCVGQIERRGLRVVGLYRlCGSAAVKKELRDAFERDSAAVCLSEdlyPDINVITGILKDYL 412
Cdd:cd04388    2 LPDLTEQFSPPDVAPPLLIKLVEAIEKKGLESSTLYR-TQSSSSLTELRQILDCDAASVDLEQ---FDVAALADALKRYL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 413 RELPTPLITQPLYkvvlEAMARDPPNrVPPTTEGT---RGLLSC--LPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLA 487
Cdd:cd04388   78 LDLPNPVIPAPVY----SEMISRAQE-VQSSDEYAqllRKLIRSpnLPHQYWLTLQYLLKHFFRLCQSSSKNLLSARALA 152

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665505952 488 VCFGPVLLPArQAPTRPRArssgpglasavdfKHHIEVLHYLLQSWPDPRLPrqspdvAPYLRPKrqPP 556
Cdd:cd04388  153 EIFSPLLFRF-QPASSDSP-------------EFHIRIIEVLITSEWNERQA------APALPPK--PP 199
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 362-501 5.44e-07

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 50.92  E-value: 5.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 362 LRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPdiNVITGILKDYLRELPTPLITQ---PLYKVVLEAMARDPPN 438
Cdd:cd04392   24 LRVEGLFRKPGNSARQQELRDLLNSGTDLDLESGGFHA--HDCATVLKGFLGELPEPLLTHahyPAHLQIADLCQFDEKG 101

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665505952 439 RVPPTTEGTRG------LLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLLPARQAP 501
Cdd:cd04392  102 NKTSAPDKERLlealqlLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFTPHLICPRNLT 170
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 344-495 1.37e-05

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 46.63  E-value: 1.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 344 GQVPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAF-ERDSAAVCLSEDLYpDINVITGILKDYLRELPTPLITQ 422
Cdd:cd04396   30 GYIPVVVAKCGVYLKENATEVEGIFRVAGSSKRIRELQLIFsTPPDYGKSFDWDGY-TVHDAASVLRRYLNNLPEPLVPL 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 423 PLYKVVLEAMARDP---------PNRVPPTT-----EGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAV 488
Cdd:cd04396  109 DLYEEFRNPLRKRPrilqymkgrINEPLNTDidqaiKEYRDLITRLPNLNRQLLLYLLDLLAVFARNSDKNLMTASNLAA 188


                 ....*..
gi 665505952 489 CFGPVLL 495
Cdd:cd04396  189 IFQPGIL 195
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 329-505 7.73e-05

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 43.92  E-value: 7.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 329 FGLPLPLLVERER---PPGQVPLIIQKCVGQI-ERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDlypdINVI 404
Cdd:cd04389    1 FGSSLEEIMDRQKekyPELKLPWILTFLSEKVlALGGFQTEGIFRVPGDIDEVNELKLRVDQWDYPLSGLED----PHVP 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 405 TGILKDYLRELPTPLITQPLYKVVLEAmARDPPNRVppttegtrGLLSCLPDVERATLTL--LLDHLRLVSSFHAYNRMT 482
Cdd:cd04389   77 ASLLKLWLRELEEPLIPDALYQQCISA-SEDPDKAV--------EIVQKLPIINRLVLCYliNFLQVFAQPENVAHTKMD 147

                        170       180
                 ....*....|....*....|...
gi 665505952 483 PQNLAVCFGPVLLpaRQAPTRPR 505
Cdd:cd04389  148 VSNLAMVFAPNIL--RCTSDDPR 168
RhoGAP_fRGD2 cd04399
RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 329-461 2.64e-04

RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD2-like proteins. Yeast Rgd2 is a GAP protein for Cdc42 and Rho5. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239864  Cd Length: 212  Bit Score: 42.70  E-value: 2.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665505952 329 FGLPLPLLVERERppGQVPLIIQKCVGQI-----------ERRGLRVVGLyRLCGSAAVKKELRDAFERDSAAVCLSEdl 397
Cdd:cd04399    1 FGVDLETRCRLDK--KVVPLIVSAILSYLdqlypdlindeVRRNVWTDPV-SLKETHQLRNLLNKPKKPDKEVIILKK-- 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665505952 398 yPDINVITGILKDYLRELPTPLITQPLYKVVLEAMARDPPNRVPPTTEGTRGL---LSCLPDVERAT 461
Cdd:cd04399   76 -FEPSTVASVLKLYLLELPDSLIPHDIYDLIRSLYSAYPPSQEDSDTARIQGLqstLSQLPKSHIAT 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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