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Conserved domains on  [gi|666637940|ref|NP_001287993|]
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RNA polymerase I-specific transcription initiation factor RRN3 isoform 2 [Homo sapiens]

Protein Classification

RNA polymerase I-specific transcription initiation factor RRN3 family protein( domain architecture ID 10526375)

RNA polymerase I-specific transcription initiation factor RRN3 family protein similar to human RRN3 that is required for efficient transcription initiation by RNA polymerase I, and for the formation of the competent preinitiation complex (PIC).

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RRN3 pfam05327
RNA polymerase I specific transcription initiation factor RRN3; This family consists of ...
 85-555 2.77e-137

RNA polymerase I specific transcription initiation factor RRN3; This family consists of several eukaryotic proteins which are homologous to the yeast RRN3 protein. RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae.


:

Pssm-ID: 461623  Cd Length: 548  Bit Score: 411.62  E-value: 2.77e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666637940   85 RLPWLNRSQTVVEEYLAFLGNLVSAQTVFLRPCLSMIASHFVPPRVIIKEGDVDVSDSDDEDdnlpanFDTCHRALQIIA 164
Cdd:pfam05327  76 SLSWLGRDESFVKAYIRFLGVLASAHPKYLSLVLSMLVSNFTPQPESSGRLPGYPPVTRREV------YERVHEALKYIL 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666637940  165 RYVPSTPWFLMPILVEKFPFVRKSERTLECYVHNLLRISVYFPTLRHEILELIIEKLLKLDVnasrqGI--------EDA 236
Cdd:pfam05327 150 RLIPTAPSVLLPILSRKFPHKRDSKKAQVTYIRNLLRLTEYCPELGSDILALIIERLIKIDV-----EIqveledldDDE 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666637940  237 EETATQTCGGTDSTEGLFNMDEDEETEHETKAGPERLD-----QMVHPVAERLDILMSLVLSYMKDVCY--VDGKVDNGK 309
Cdd:pfam05327 225 DEELLEQLDEDDDDDDDDDSDDDSDSSDDGLDDDEEDDevqriKKIKELVEKLDAILDLLFEHLDSKFSsgSPEELNEGE 304

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666637940  310 TKDLYRDLINIFDKLLLPTHASCHVQFFMFYLCSFKLGFAEAFLEHLWKKLQDPSNPAIIRQAAGNYIGSFLARAKFIPL 389
Cdd:pfam05327 305 GVEVFNTLLSLFKSTILPTYRSRHTQFLLFHFSQLSPELMDSFLGTLIDIAFDPNEPAITRQAAAAYLASFVARAKFVSR 384

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666637940  390 ITVKSCLDLLVNWLHIYLNNQDSGTKAfCDVALHGPFYSACQAVFYTFVFRHKQLL---SGNLKEGLQYLQSLN--FERI 464
Cdd:pfam05327 385 SQVRFVLSYLCDWLNRYVDEREEECRG-PDLKRHGVFYAVCQALLYIFCFRWRDLTdadDDEEGGDLEWLPGLDefLQRA 463

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666637940  465 VMSQLNPLKICLPSVVNFFAAITNKYQLVFCYTIIERNNRqmlpviRSTAGGDSVQIcTNPLDTFFPFDPCVLKRSKKFI 544
Cdd:pfam05327 464 IYSKLNPLKVCSPNVVTEFARIAHHLQFAYCFSIIESNKR------EETAGTATGQE-FEQLDAYFPFDPYLLPRSKRWI 536

                         490
                  ....*....|.
gi 666637940  545 DPIYQVWEDMS 555
Cdd:pfam05327 537 EPDYVEWSEVA 547
 
Name Accession Description Interval E-value
RRN3 pfam05327
RNA polymerase I specific transcription initiation factor RRN3; This family consists of ...
 85-555 2.77e-137

RNA polymerase I specific transcription initiation factor RRN3; This family consists of several eukaryotic proteins which are homologous to the yeast RRN3 protein. RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae.


Pssm-ID: 461623  Cd Length: 548  Bit Score: 411.62  E-value: 2.77e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666637940   85 RLPWLNRSQTVVEEYLAFLGNLVSAQTVFLRPCLSMIASHFVPPRVIIKEGDVDVSDSDDEDdnlpanFDTCHRALQIIA 164
Cdd:pfam05327  76 SLSWLGRDESFVKAYIRFLGVLASAHPKYLSLVLSMLVSNFTPQPESSGRLPGYPPVTRREV------YERVHEALKYIL 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666637940  165 RYVPSTPWFLMPILVEKFPFVRKSERTLECYVHNLLRISVYFPTLRHEILELIIEKLLKLDVnasrqGI--------EDA 236
Cdd:pfam05327 150 RLIPTAPSVLLPILSRKFPHKRDSKKAQVTYIRNLLRLTEYCPELGSDILALIIERLIKIDV-----EIqveledldDDE 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666637940  237 EETATQTCGGTDSTEGLFNMDEDEETEHETKAGPERLD-----QMVHPVAERLDILMSLVLSYMKDVCY--VDGKVDNGK 309
Cdd:pfam05327 225 DEELLEQLDEDDDDDDDDDSDDDSDSSDDGLDDDEEDDevqriKKIKELVEKLDAILDLLFEHLDSKFSsgSPEELNEGE 304

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666637940  310 TKDLYRDLINIFDKLLLPTHASCHVQFFMFYLCSFKLGFAEAFLEHLWKKLQDPSNPAIIRQAAGNYIGSFLARAKFIPL 389
Cdd:pfam05327 305 GVEVFNTLLSLFKSTILPTYRSRHTQFLLFHFSQLSPELMDSFLGTLIDIAFDPNEPAITRQAAAAYLASFVARAKFVSR 384

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666637940  390 ITVKSCLDLLVNWLHIYLNNQDSGTKAfCDVALHGPFYSACQAVFYTFVFRHKQLL---SGNLKEGLQYLQSLN--FERI 464
Cdd:pfam05327 385 SQVRFVLSYLCDWLNRYVDEREEECRG-PDLKRHGVFYAVCQALLYIFCFRWRDLTdadDDEEGGDLEWLPGLDefLQRA 463

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666637940  465 VMSQLNPLKICLPSVVNFFAAITNKYQLVFCYTIIERNNRqmlpviRSTAGGDSVQIcTNPLDTFFPFDPCVLKRSKKFI 544
Cdd:pfam05327 464 IYSKLNPLKVCSPNVVTEFARIAHHLQFAYCFSIIESNKR------EETAGTATGQE-FEQLDAYFPFDPYLLPRSKRWI 536

                         490
                  ....*....|.
gi 666637940  545 DPIYQVWEDMS 555
Cdd:pfam05327 537 EPDYVEWSEVA 547
 
Name Accession Description Interval E-value
RRN3 pfam05327
RNA polymerase I specific transcription initiation factor RRN3; This family consists of ...
 85-555 2.77e-137

RNA polymerase I specific transcription initiation factor RRN3; This family consists of several eukaryotic proteins which are homologous to the yeast RRN3 protein. RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae.


Pssm-ID: 461623  Cd Length: 548  Bit Score: 411.62  E-value: 2.77e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666637940   85 RLPWLNRSQTVVEEYLAFLGNLVSAQTVFLRPCLSMIASHFVPPRVIIKEGDVDVSDSDDEDdnlpanFDTCHRALQIIA 164
Cdd:pfam05327  76 SLSWLGRDESFVKAYIRFLGVLASAHPKYLSLVLSMLVSNFTPQPESSGRLPGYPPVTRREV------YERVHEALKYIL 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666637940  165 RYVPSTPWFLMPILVEKFPFVRKSERTLECYVHNLLRISVYFPTLRHEILELIIEKLLKLDVnasrqGI--------EDA 236
Cdd:pfam05327 150 RLIPTAPSVLLPILSRKFPHKRDSKKAQVTYIRNLLRLTEYCPELGSDILALIIERLIKIDV-----EIqveledldDDE 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666637940  237 EETATQTCGGTDSTEGLFNMDEDEETEHETKAGPERLD-----QMVHPVAERLDILMSLVLSYMKDVCY--VDGKVDNGK 309
Cdd:pfam05327 225 DEELLEQLDEDDDDDDDDDSDDDSDSSDDGLDDDEEDDevqriKKIKELVEKLDAILDLLFEHLDSKFSsgSPEELNEGE 304

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666637940  310 TKDLYRDLINIFDKLLLPTHASCHVQFFMFYLCSFKLGFAEAFLEHLWKKLQDPSNPAIIRQAAGNYIGSFLARAKFIPL 389
Cdd:pfam05327 305 GVEVFNTLLSLFKSTILPTYRSRHTQFLLFHFSQLSPELMDSFLGTLIDIAFDPNEPAITRQAAAAYLASFVARAKFVSR 384

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666637940  390 ITVKSCLDLLVNWLHIYLNNQDSGTKAfCDVALHGPFYSACQAVFYTFVFRHKQLL---SGNLKEGLQYLQSLN--FERI 464
Cdd:pfam05327 385 SQVRFVLSYLCDWLNRYVDEREEECRG-PDLKRHGVFYAVCQALLYIFCFRWRDLTdadDDEEGGDLEWLPGLDefLQRA 463

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666637940  465 VMSQLNPLKICLPSVVNFFAAITNKYQLVFCYTIIERNNRqmlpviRSTAGGDSVQIcTNPLDTFFPFDPCVLKRSKKFI 544
Cdd:pfam05327 464 IYSKLNPLKVCSPNVVTEFARIAHHLQFAYCFSIIESNKR------EETAGTATGQE-FEQLDAYFPFDPYLLPRSKRWI 536

                         490
                  ....*....|.
gi 666637940  545 DPIYQVWEDMS 555
Cdd:pfam05327 537 EPDYVEWSEVA 547
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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