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Conserved domains on  [gi|700584700|ref|NP_001289474|]
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angio-associated migratory cell protein isoform 1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10078108)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; similar to Homo sapiens angio-associated migratory cell protein that plays a role in angiogenesis and cell migration

Gene Ontology:  GO:0005515
PubMed:  10322433

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 87-387 2.73e-60

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 197.94  E-value: 2.73e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700584700  87 TFALHSASVFCVSLDPKTNTLAvTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDT 166
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLA-TGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700584700 167 KEEVWSFE--AGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDCK-TFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIW 243
Cdd:cd00200   83 GECVRTLTghTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLtTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700584700 244 DLKQGSPIHVLkgtEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVAsqpslgegeesesnsves 323
Cdd:cd00200  163 DLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG------------------ 221

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 700584700 324 LGFCSVMP---LAAVGYLDGTLAIYDLATQTLRHQCQ-HQSGIVQLLWEAGTAVVYTCSLDGIVRLWD 387
Cdd:cd00200  222 VNSVAFSPdgyLLASGSEDGTIRVWDLRTGECVQTLSgHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 390-428 1.07e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


:

Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.07e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 700584700   390 TGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVF 428
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 87-387 2.73e-60

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 197.94  E-value: 2.73e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700584700  87 TFALHSASVFCVSLDPKTNTLAvTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDT 166
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLA-TGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700584700 167 KEEVWSFE--AGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDCK-TFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIW 243
Cdd:cd00200   83 GECVRTLTghTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLtTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700584700 244 DLKQGSPIHVLkgtEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVAsqpslgegeesesnsves 323
Cdd:cd00200  163 DLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG------------------ 221

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 700584700 324 LGFCSVMP---LAAVGYLDGTLAIYDLATQTLRHQCQ-HQSGIVQLLWEAGTAVVYTCSLDGIVRLWD 387
Cdd:cd00200  222 VNSVAFSPdgyLLASGSEDGTIRVWDLRTGECVQTLSgHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
87-427 2.73e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 175.10  E-value: 2.73e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700584700  87 TFALHSASVFCVSLDPKTNTLAvTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDT 166
Cdd:COG2319   73 TLLGHTAAVLSVAFSPDGRLLA-SASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700584700 167 KEEVWSFE--AGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDC-KTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIW 243
Cdd:COG2319  152 GKLLRTLTghSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700584700 244 DLKQGSPIHVLKGtegHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVAsqpslgegeesesnsves 323
Cdd:COG2319  232 DLATGKLLRTLTG---HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG------------------ 290

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700584700 324 lgfcsVMPLA--------AVGYLDGTLAIYDLATQTLRHQCQ-HQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLL 394
Cdd:COG2319  291 -----VNSVAfspdgkllASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL 365

                        330       340       350
                 ....*....|....*....|....*....|...
gi 700584700 395 TDYRGHTAEILDFALSKDASLVVTTSGDHKAKV 427
Cdd:COG2319  366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 124-162 3.61e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 3.61e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 700584700   124 DGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVW 162
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
125-162 2.63e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.63e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 700584700  125 GELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVW 162
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 390-428 1.07e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.07e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 700584700   390 TGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVF 428
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 87-387 2.73e-60

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 197.94  E-value: 2.73e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700584700  87 TFALHSASVFCVSLDPKTNTLAvTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDT 166
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLA-TGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700584700 167 KEEVWSFE--AGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDCK-TFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIW 243
Cdd:cd00200   83 GECVRTLTghTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLtTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700584700 244 DLKQGSPIHVLkgtEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVAsqpslgegeesesnsves 323
Cdd:cd00200  163 DLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG------------------ 221

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 700584700 324 LGFCSVMP---LAAVGYLDGTLAIYDLATQTLRHQCQ-HQSGIVQLLWEAGTAVVYTCSLDGIVRLWD 387
Cdd:cd00200  222 VNSVAFSPdgyLLASGSEDGTIRVWDLRTGECVQTLSgHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
87-427 2.73e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 175.10  E-value: 2.73e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700584700  87 TFALHSASVFCVSLDPKTNTLAvTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDT 166
Cdd:COG2319   73 TLLGHTAAVLSVAFSPDGRLLA-SASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700584700 167 KEEVWSFE--AGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDC-KTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIW 243
Cdd:COG2319  152 GKLLRTLTghSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700584700 244 DLKQGSPIHVLKGtegHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVAsqpslgegeesesnsves 323
Cdd:COG2319  232 DLATGKLLRTLTG---HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG------------------ 290

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700584700 324 lgfcsVMPLA--------AVGYLDGTLAIYDLATQTLRHQCQ-HQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLL 394
Cdd:COG2319  291 -----VNSVAfspdgkllASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELL 365

                        330       340       350
                 ....*....|....*....|....*....|...
gi 700584700 395 TDYRGHTAEILDFALSKDASLVVTTSGDHKAKV 427
Cdd:COG2319  366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
87-427 7.08e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 155.45  E-value: 7.08e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700584700  87 TFALHSASVFCVSLDPkTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDT 166
Cdd:COG2319   31 LLLGLAAAVASLAASP-DGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700584700 167 KEEVWSFEA--GDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDC-KTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIW 243
Cdd:COG2319  110 GLLLRTLTGhtGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLlRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700584700 244 DLKQGSPIHVLKgteGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETvasqpslgegeesesnsvES 323
Cdd:COG2319  190 DLATGKLLRTLT---GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHS------------------GS 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700584700 324 LGFCSVMP---LAAVGYLDGTLAIYDLATQTLRHQCQHQSGIVqllweagTAVVY--------TCSLDGIVRLWDARTGR 392
Cdd:COG2319  249 VRSVAFSPdgrLLASGSADGTVRLWDLATGELLRTLTGHSGGV-------NSVAFspdgkllaSGSDDGTVRLWDLATGK 321

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 700584700 393 LLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKV 427
Cdd:COG2319  322 LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356
WD40 COG2319
WD40 repeat [General function prediction only];
107-428 2.05e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 137.74  E-value: 2.05e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700584700 107 LAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKEEVWSFE--AGDLEWMEWH 184
Cdd:COG2319    8 ALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLghTAAVLSVAFS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700584700 185 PRAPVLLAGTADGNTWMWKVPNGDCK-TFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGtegHQGP 263
Cdd:COG2319   88 PDGRLLASASADGTVRLWDLATGLLLrTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG---HSGA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700584700 264 LTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVAsqpslgegeesesnsveslgfcsVMPLA--------AV 335
Cdd:COG2319  165 VTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA-----------------------VRSVAfspdgkllAS 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700584700 336 GYLDGTLAIYDLATQTLRHQCQHQSGIVQ-LLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDAS 414
Cdd:COG2319  222 GSADGTVRLWDLATGKLLRTLTGHSGSVRsVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGK 301

                        330
                 ....*....|....
gi 700584700 415 LVVTTSGDHKAKVF 428
Cdd:COG2319  302 LLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 326-431 1.36e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.99  E-value: 1.36e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700584700 326 FCSVMPLAAVGYLDGTLAIYDLAT-QTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEI 404
Cdd:cd00200   17 FSPDGKLLATGSGDGTIKVWDLETgELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYV 96

                         90       100
                 ....*....|....*....|....*..
gi 700584700 405 LDFALSKDASLVVTTSGDHKAKVFCVQ 431
Cdd:cd00200   97 SSVAFSPDGRILSSSSRDKTIKVWDVE 123
WD40 COG2319
WD40 repeat [General function prediction only];
223-431 2.10e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.48  E-value: 2.10e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700584700 223 RVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLkgtEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPE 302
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLL---LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGH 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700584700 303 TVAsqpslgegeesesnsVESLGFCSVMPLAAVGYLDGTLAIYDLATQTLRHQCQ-HQSGIVQLLWEAGTAVVYTCSLDG 381
Cdd:COG2319   78 TAA---------------VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTgHTGAVRSVAFSPDGKTLASGSADG 142

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 700584700 382 IVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVFCVQ 431
Cdd:COG2319  143 TVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA 192
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 124-162 3.61e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 3.61e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 700584700   124 DGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVW 162
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
125-162 2.63e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.63e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 700584700  125 GELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVW 162
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 181-267 1.25e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 40.72  E-value: 1.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700584700  181 MEWHPRAPVLLAGTADGNTWM--------WKVPNGdcktfqGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIH 252
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLhrlnwqrvWTLSPD------KEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVH 74

                          90
                  ....*....|....*
gi 700584700  253 VLKgteGHQGPLTCV 267
Cdd:pfam12894  75 HFS---AGSDLITCL 86
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 209-244 1.75e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.75e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 700584700   209 CKTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWD 244
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 247-287 2.11e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.11e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 700584700   247 QGSPIHVLKGtegHQGPLTCVAANQDGSLILTGSVDCQAKL 287
Cdd:smart00320   1 SGELLKTLKG---HTGPVTSVAFSPDGKYLASGSDDGTIKL 38
WD40 pfam00400
WD domain, G-beta repeat;
248-287 4.42e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 4.42e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 700584700  248 GSPIHVLKGtegHQGPLTCVAANQDGSLILTGSVDCQAKL 287
Cdd:pfam00400   1 GKLLKTLEG---HTGSVTSLAFSPDGKLLASGSDDGTVKV 37
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 390-428 1.07e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.07e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 700584700   390 TGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVF 428
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
210-244 3.05e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 3.05e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 700584700  210 KTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWD 244
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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