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Conserved domains on  [gi|705043713|ref|NP_001289608|]
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adenosine receptor A3 isoform C [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
 1-148 9.73e-72

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15070:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 280  Bit Score: 217.72  E-value: 9.73e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713   1 MFGWNMKLTSEyHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGRE 80
Cdd:cd15070  134 MFGWNRKPSLE-SVNTTPLQCQFTSVMRMDYMVYFSFFTWILIPLVIMCALYVDIFYIIRNKLSQNATGFRETGAFYGRE 212

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 705043713  81 FKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETY 148
Cdd:cd15070  213 FKTAKSLALVLFLFAVCWLPLSIINCVVYFNPKVPKIALYLGILLSHANSMMNPIVYACKIKKFKETY 280
 
Name Accession Description Interval E-value
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
 1-148 9.73e-72

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 217.72  E-value: 9.73e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713   1 MFGWNMKLTSEyHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGRE 80
Cdd:cd15070  134 MFGWNRKPSLE-SVNTTPLQCQFTSVMRMDYMVYFSFFTWILIPLVIMCALYVDIFYIIRNKLSQNATGFRETGAFYGRE 212

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 705043713  81 FKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETY 148
Cdd:cd15070  213 FKTAKSLALVLFLFAVCWLPLSIINCVVYFNPKVPKIALYLGILLSHANSMMNPIVYACKIKKFKETY 280
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
 8-137 1.78e-05

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 43.44  E-value: 1.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713    8 LTSEYHRNVTFLSCQF----VSVMRMDYMVYFSFLTWiFIPLVVMCAIYLDIFYIIRNKlslnlSNSKETGAFYGREFKT 83
Cdd:pfam00001 124 GWTLTVPEGNVTVCFIdfpeDLSKPVSYTLLISVLGF-LLPLLVILVCYTLIIRTLRKS-----ASKQKSSERTQRRRKA 197

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 705043713   84 AKSLFLVLFLFALSWLPLSIINCIIYFNGEVP-----QLVLYMGILLSHANSMMNPIVY 137
Cdd:pfam00001 198 LKTLAVVVVVFILCWLPYHIVNLLDSLALDCElsrllDKALSVTLWLAYVNSCLNPIIY 256
 
Name Accession Description Interval E-value
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
 1-148 9.73e-72

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 217.72  E-value: 9.73e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713   1 MFGWNMKLTSEyHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGRE 80
Cdd:cd15070  134 MFGWNRKPSLE-SVNTTPLQCQFTSVMRMDYMVYFSFFTWILIPLVIMCALYVDIFYIIRNKLSQNATGFRETGAFYGRE 212

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 705043713  81 FKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETY 148
Cdd:cd15070  213 FKTAKSLALVLFLFAVCWLPLSIINCVVYFNPKVPKIALYLGILLSHANSMMNPIVYACKIKKFKETY 280
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
 1-148 3.41e-60

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 188.23  E-value: 3.41e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713   1 MFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSN--SKETGAFYG 78
Cdd:cd14968  134 MFGWNNGAPLESGCGEGGIQCLFEEVIPMDYMVYFNFFACVLVPLLIMLVIYLRIFRVIRKQLRQIESLlrSRRSRSTLQ 213

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 705043713  79 REFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGE--VPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETY 148
Cdd:cd14968  214 KEVKAAKSLAIILFLFALCWLPLHIINCITLFCPEckVPKILTYIAILLSHANSAVNPIVYAYRIRKFRQTF 285
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
 1-148 5.64e-36

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 126.50  E-value: 5.64e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713   1 MFGWN--MKLTSEYHRNVT----FLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLS-LNLSNSKET 73
Cdd:cd15071  134 MFGWNnlNAVERAWAANSSmgelVIKCQFETVISMEYMVYFNFFVWVLPPLLLMLLIYLEVFYLIRKQLNkKVSSSSSDP 213

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 705043713  74 GAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYF--NGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETY 148
Cdd:cd15071  214 QKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFcpSCKKPMILTYIAIFLTHGNSAMNPIVYAFRIKKFRTTF 290
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
 1-148 2.73e-28

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 106.17  E-value: 2.73e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713   1 MFGWNMKLTSEYHRNVT------FLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNS---K 71
Cdd:cd15068  134 MLGWNNCGQPKEGKNHSqgcgegQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPlpgE 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  72 ETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEV---PQLVLYMGILLSHANSMMNPIVYAYKIKKFKETY 148
Cdd:cd15068  214 RARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCshaPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTF 293
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
 18-148 6.99e-27

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 102.70  E-value: 6.99e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  18 FLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLN--LSNSKETgafYGREFKTAKSLFLVLFLFA 95
Cdd:cd15069  161 LISCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTelMDHSRTT---LQREIHAAKSLAIIVGIFA 237

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 705043713  96 LSWLPLSIINCIIYFNGEV----PQLVLYMGILLSHANSMMNPIVYAYKIKKFKETY 148
Cdd:cd15069  238 LCWLPVHILNCITLFQPEFskskPKWAMNVAILLSHANSVVNPIVYAYRNRDFRYTF 294
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
 1-140 1.34e-10

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 58.07  E-value: 1.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713   1 MFGWNmklTSEYHRNVTFLSCQFVSVMRMDYMVYFsFLTWIFIPLVVMCAIYLDIFYIIR--NKLSLNLSNSKETGAFYG 78
Cdd:cd00637  134 LLGWG---VYDYGGYCCCCLCWPDLTLSKAYTIFL-FVLLFLLPLLVIIVCYVRIFRKLRrhRRRIRSSSSNSSRRRRRR 209

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 705043713  79 REFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGE---VPQLVLYMGILLSHANSMMNPIVYAYK 140
Cdd:cd00637  210 RERKVTKTLLIVVVVFLLCWLPYFILLLLDVFGPDpspLPRILYFLALLLAYLNSAINPIIYAFF 274
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
 31-148 1.12e-09

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 55.65  E-value: 1.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  31 YMVYFSFLTWIFIPLVVMCAIYLDIFYIIRnklslnlsnsketgafygREFKTAKSLFLVLFLFALSWLPLSIINCIIYF 110
Cdd:cd14967  158 IYVLVSSVISFFIPLLIMIVLYARIFRVAR------------------RELKAAKTLAIIVGAFLLCWLPFFIIYLVSAF 219

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 705043713 111 NGE--VPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETY 148
Cdd:cd14967  220 CPPdcVPPILYAVFFWLGYLNSALNPIIYALFNRDFRRAF 259
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
 31-148 2.68e-08

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 51.95  E-value: 2.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  31 YMVYFSFLTWiFIPLVVMCAIYLDIFYIIR------NKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSII 104
Cdd:cd15051  164 YVLLVAIGTF-YLPLLIMCGVYLRIFRIAReqakriNALTPASTANSSKSAATAREHKATVTLAAVLGAFIICWFPYFTY 242

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 705043713 105 NCIIYFNGEVPQLVLYMGIL-LSHANSMMNPIVYAYKIKKFKETY 148
Cdd:cd15051  243 FTYRGLCGDNINETALSVVLwLGYANSALNPILYAFLNRDFRRAF 287
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
 2-148 5.69e-08

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 50.79  E-value: 5.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713   2 FGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLtwIFIPLVVMCAIYLDIFYIIRN----------KLSLNLSNSK 71
Cdd:cd15083  137 FGWSRYVLEGLLTSCSFDYLSRDDANRSYVICLLIFG--FVLPLLIIIYCYSFIFRAVRRhekamkemakRFSKSELSSP 214

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 705043713  72 ETGAfyGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGE--VPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETY 148
Cdd:cd15083  215 KARR--QAEVKTAKIALLLVLLFCLAWTPYAVVALIGQFGYLevLTPLATAIPAAFAKTSAIYNPVIYAFSHPKFRRAL 291
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
 37-147 8.72e-08

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 50.37  E-value: 8.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  37 FLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKET-GAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEV- 114
Cdd:cd14972  161 ILVFFFIALVIIVFLYVRIFWCLWRHANAIAARQEAAvPAQPSTSRKLAKTVVIVLGVFLVCWLPLLILLVLDVLCPSVc 240

                         90       100       110
                 ....*....|....*....|....*....|....
gi 705043713 115 -PQLVLYMGILLSHANSMMNPIVYAYKIKKFKET 147
Cdd:cd14972  241 dIQAVFYYFLVLALLNSAINPIIYAFRLKEMRRA 274
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
 20-139 1.57e-06

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 46.65  E-value: 1.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  20 SCQFVSVMRMDYMVYFSFLTWiFIPLVVMCAIYLDIFYIIR----------NKLSLNLSNSKETGAFYGREFKTAKSLFL 89
Cdd:cd15057  156 PCQCDSSLNRTYAISSSLISF-YIPVAIMIVTYTRIYRIARrqirriaaleRAAQESTNPDSSLRSSLRRETKALKTLSI 234

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 705043713  90 VLFLFALSWLPLSIINCIIYFNGE-------VPQLVLYMGILLSHANSMMNPIVYAY 139
Cdd:cd15057  235 IMGVFVCCWLPFFILNCVLPFCDLrtaqfpcVPDTTFIVFVWLGWANSSLNPIIYAF 291
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
 33-139 2.20e-06

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 46.29  E-value: 2.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  33 VYFSFLTWiFIPLVVMCAIYLDIFYIIR----------NKLSLNLSNSKETGAfyGREFKTAKSLFLVLFLFALSWLPLS 102
Cdd:cd15317  167 VLLDFLTF-FIPCLIMIGLYAKIFLVARrqarkiqnmeDKFRSSEENSSKASA--SRERKAAKTLAIVMGIFLFCWLPYF 243

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 705043713 103 IINCII-YFNGEVPQLVLYMGILLSHANSMMNPIVYAY 139
Cdd:cd15317  244 IDTIVDeYSNFITPAIVFDAVIWLGYFNSAFNPFIYAF 281
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
 35-139 2.96e-06

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 45.70  E-value: 2.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  35 FSFltwiFIPLVVMCAIYLDIFYIIRNKL-SLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCII-YFNG 112
Cdd:cd15314  171 FSF----YIPAVIMLCIYLKIFLVAQRQArSIQSARTKSGASSSKMERKATKTLAIVMGVFLLCWTPFFLCNIIDpFINY 246

                         90       100
                 ....*....|....*....|....*..
gi 705043713 113 EVPQLVLYMGILLSHANSMMNPIVYAY 139
Cdd:cd15314  247 SIPPVLIEVLNWLGYSNSTLNPFIYAF 273
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
 31-148 4.48e-06

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 45.35  E-value: 4.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  31 YMVYFSFLTWiFIPLVVMCAIYLDIFYIIrnklslnlsnsketgafyGREFKTAKSLFLVLFLFALSWLPLSIINCIIYF 110
Cdd:cd15330  159 YTIYSTFGAF-YIPLILMLVLYGRIFKAA------------------ARERKTVKTLGIIMGTFILCWLPFFIVALVLPF 219

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 705043713 111 ---NGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETY 148
Cdd:cd15330  220 cesTCHMPELLGAIINWLGYSNSLLNPIIYAYFNKDFQSAF 260
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
 31-147 4.68e-06

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 45.27  E-value: 4.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  31 YMVYFsFLTWIFIPLVVMCAIYLDIFYIIRN--KLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCII 108
Cdd:cd14969  164 YIVSL-FVFCFFLPLAIIIFCYYKIYRTLRKmsKRAARRKNSAITKRTKKAEKKVAKMVLVMIVAFLIAWTPYAVVSLYV 242

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 705043713 109 YFNGE--VPQLVLYMGILLSHANSMMNPIVYAYKIKKFKET 147
Cdd:cd14969  243 SFGGEstIPPLLATIPALFAKSSTIYNPIIYVFMNKQFRRA 283
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
 20-145 7.29e-06

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 44.67  E-value: 7.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  20 SCQFVSVMRMDYMVYFSFLTWiFIPLVVMCAIYLDIFYIIRN------KLSLNLSNSKETgAFYGREFKTAKSLFLVLFL 93
Cdd:cd15104  149 KCSFFAAFHPRVLLVLSCMVF-FPALLLFVFCYCDILKIARVhsraiyKVEHALARQIHP-RRTLSDFKAARTVAVLIGC 226

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 705043713  94 FALSWLPLSIINCIIYFNGE--VPQLVLYMGILLSHANSMMNPIVYAYKIKKFK 145
Cdd:cd15104  227 FLLSWLPFQITGLVQALCDEckLYDVLEDYLWLLGLCNSLLNPWIYAFWQKEVR 280
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
 8-137 1.78e-05

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 43.44  E-value: 1.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713    8 LTSEYHRNVTFLSCQF----VSVMRMDYMVYFSFLTWiFIPLVVMCAIYLDIFYIIRNKlslnlSNSKETGAFYGREFKT 83
Cdd:pfam00001 124 GWTLTVPEGNVTVCFIdfpeDLSKPVSYTLLISVLGF-LLPLLVILVCYTLIIRTLRKS-----ASKQKSSERTQRRRKA 197

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 705043713   84 AKSLFLVLFLFALSWLPLSIINCIIYFNGEVP-----QLVLYMGILLSHANSMMNPIVY 137
Cdd:pfam00001 198 LKTLAVVVVVFILCWLPYHIVNLLDSLALDCElsrllDKALSVTLWLAYVNSCLNPIIY 256
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
 33-139 1.87e-05

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 43.69  E-value: 1.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  33 VYFSFLTWiFIPLVVMCAIYLDIFYIIRN---KLSLNLSNSKETGAFYG-----REFKTAKSLFLVLFLFALSWLPLSII 104
Cdd:cd15316  167 VLVDFLLF-FIPTFAMIILYGKIFLVAKQqarKIEMTSSKAESSSESYKdrvarRERKAAKTLGITVIAFLVSWLPYLID 245

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 705043713 105 NCI-IYFNGEVPQLVLYMGILLSHANSMMNPIVYAY 139
Cdd:cd15316  246 VLIdAFMNFITPPYIYEICCWCAYYNSAMNPLIYAL 281
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
 33-145 5.88e-05

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 41.96  E-value: 5.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  33 VYFSFLTWIFIPLVVMCAIYLDIFYIIrnklslnlsnsketgafyGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNG 112
Cdd:cd15067  161 LIFSSCVSFYIPLVVMLFTYYRIYRAA------------------AKEQKAAKTLGIVMGVFILCWLPFFVTNILIGFCP 222

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 705043713 113 EV----PQLVLYMGILLSHANSMMNPIVYAYKIKKFK 145
Cdd:cd15067  223 SNcvsnPDILFPLVTWLGYINSGMNPIIYACSSRDFR 259
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
 34-148 7.42e-05

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 41.54  E-value: 7.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  34 YFSFLTWI---FIPLVVMCAIYLDIFYIIRnklslnlsnsketgafygREFKTAKSLFLVLFLFALSWLPLSIINCIIYF 110
Cdd:cd15049  162 AITFGTAIaafYLPVLVMTILYWRIYRETA------------------RERKAARTLSAILLAFIITWTPYNILVLVSTF 223

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 705043713 111 -NGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETY 148
Cdd:cd15049  224 cAKCIPDTLWSFGYWLCYINSTINPFCYALCNKTFRKTF 262
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
 42-146 8.45e-05

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 41.77  E-value: 8.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  42 FIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCI-IYFNGEVPQLVLY 120
Cdd:cd15318  175 FIPCLIMIGLYVKIFIVAKRQARAIASLLSDTNGASKRERKAAKTLGIAVGVYLLCWLPFTIDTMVdSLLNFITPPLLFD 254

                         90       100
                 ....*....|....*....|....*.
gi 705043713 121 MGILLSHANSMMNPIVYAYKIKKFKE 146
Cdd:cd15318  255 IIIWFAYFNSACNPLIYVFSYPWFRK 280
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
 33-146 8.82e-05

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 41.74  E-value: 8.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  33 VYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNG 112
Cdd:cd15078  162 VLLFFLGCLVVPLGIMAYCYGHILYEIRMLRSVEDLQTFQVIKILKYEKKVAKMCLLMISTFLICWMPYAVVSLLVTSGY 241

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 705043713 113 E--VPQLVLYMGILLSHANSMMNPIVYAYKIKKFKE 146
Cdd:cd15078  242 SklVTPTIAIIPSLFAKSSTAYNPVIYIFMIRKFRQ 277
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
 35-145 1.24e-04

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 41.05  E-value: 1.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  35 FSFLTWIFIPLVVMCAIYLDIFY-----IIRNKLSLNLSNSKETGAFYGRefKTAKSLFLVLFLFALSWLPLSIINCIIY 109
Cdd:cd14993  173 ALFVVLYVLPLLIISVAYSLIGRrlwrrKPPGDRGSANSTSSRRILRSKK--KVARMLIVVVVLFALSWLPYYVLSILLD 250

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 705043713 110 FNGEVPQL-------VLYMGILLSHANSMMNPIVYAYKIKKFK 145
Cdd:cd14993  251 FGPLSSEEsdenfllILPFAQLLGYSNSAINPIIYCFMSKKFR 293
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
 21-137 1.52e-04

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 40.90  E-value: 1.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  21 CQFVSvmRMDYMVYFSFLTWiFIPLVVMCAIYLDIFYIIRNKLSL-----------NLSNSKETGA------------FY 77
Cdd:cd15058  158 CDFRT--NMAYAIASSVVSF-YIPLLIMIFVYARVFLIATRQLQLidkrrlrfqseCPAPQTTSPEgkrssgrrpsrlTV 234

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 705043713  78 GREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEV-PQLVLYMGILLSHANSMMNPIVY 137
Cdd:cd15058  235 VKEHKALKTLGIIMGTFTLCWLPFFIANIINVFNRNLpPGEVFLLLNWLGYINSGLNPIIY 295
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
 33-147 1.66e-04

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 40.77  E-value: 1.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  33 VYFSFLTWIFIPLVVMCAIYLDIFYIIRNK--------LSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSII 104
Cdd:cd15337  167 ILGLFIFGFLCPLLIIIFCYVNIIRAVRNHekemtqtaKSGMGKDTEKNDARKKAEIRIAKVAIILISLFLLSWTPYAVV 246

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 705043713 105 NCIIYFNGE--VPQLVLYMGILLSHANSMMNPIVYAYKIKKFKET 147
Cdd:cd15337  247 ALLGQFGPAywITPYVSELPVMFAKASAIYNPIIYALSHPKFRAA 291
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
 1-147 2.11e-04

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 40.47  E-value: 2.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713   1 MFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLtwIFIPLVVMCAIYLDIFYIIRNK----LSLNLSNSKETGAF 76
Cdd:cd15336  136 LFGWSAYVPEGLLTSCTWDYMTFTPSVRAYTMLLFCFV--FFIPLGIIIYCYLFIFLAIRSTgrevQKLGSQDRKEKAKQ 213

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 705043713  77 YGR---EFKTAKSLFLVLFLFALSWLPLSIINcIIYFNGEVPQLVLYMG---ILLSHANSMMNPIVYAYKIKKFKET 147
Cdd:cd15336  214 YQRmknEWKMAKIAFVVILLFVLSWSPYACVA-LIAWAGYAHLLTPYMKsvpAVIAKASAIYNPIIYAITHPKYREA 289
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
 33-145 2.17e-04

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 40.42  E-value: 2.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  33 VYFSFLTWIFIPLVVMCAIYLDIFYIIRnklslnlsnsketgafygREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNG 112
Cdd:cd15061  158 RIYSSMGSFFLPLLLMLFVYLRIFRVIA------------------KERKTAKTLAIVVGCFIVCWLPFFIMYLIEPFCD 219

                         90       100       110
                 ....*....|....*....|....*....|....
gi 705043713 113 EVPQLVLYMGIL-LSHANSMMNPIVYAYKIKKFK 145
Cdd:cd15061  220 CQFSEALSTAFTwLGYFNSVINPFIYAFYNKDFR 253
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
 2-146 3.85e-04

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 39.64  E-value: 3.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713   2 FGWNMKLTSEYHRNVTFLSCQFVSVMRMD--YMVYFSFLTWiFIPLVVMCAIYLDIFYIIR---------------NKLS 64
Cdd:cd15065  137 LGWHRLSQDEIKGLNHASNPKPSCALDLNptYAVVSSLISF-YIPCLVMLLIYSRLYLYARkhvvniksqklpsesGSKF 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  65 LNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGE-VPQLVLYMGILLSHANSMMNPIVYAYKIKK 143
Cdd:cd15065  216 QVPSLSSKHNNQGVSDHKAAVTLGIIMGVFLICWLPFFIINIIAAFCKTcIPPKCFKILTWLGYFNSCLNPIIYSIFNSE 295


                 ...
gi 705043713 144 FKE 146
Cdd:cd15065  296 FRR 298
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
 35-148 4.20e-04

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 39.49  E-value: 4.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  35 FSFLTWIFIPLVVMCAIYLDIfYIIRNKLSlnlsnsketgafygREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEV 114
Cdd:cd15326  161 FSSLGSFYIPLIVILVMYCRV-YIVALKFS--------------REKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSHL 225

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 705043713 115 --PQLVLYMGILLSHANSMMNPIVYAYKIKKFKETY 148
Cdd:cd15326  226 kpPETLFKIIFWLGYFNSCLNPIIYPCSSKEFKRAF 261
7tmA_GPR6 cd15962
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...
 20-140 4.52e-04

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320628 [Multi-domain]  Cd Length: 268  Bit Score: 39.53  E-value: 4.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  20 SCQFVSVMRMDYMVYFSflTWIFIPLVVMCAIYLDIFYII-RNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSW 98
Cdd:cd15962  143 SCSIVRPLTKSNVTLLS--ASFFFIFILMLHLYIKICKIVcRHAHQIALQQHFLTASHYVATKKGVSTLAIILGTFGASW 220

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 705043713  99 LPLSIInCIIYfNGEVPQLVLYMGILLSHANSMMNPIVYAYK 140
Cdd:cd15962  221 LPFAIY-CVVG-DHEYPAVYTYATLLPATYNSMINPIIYAYR 260
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
 36-139 7.43e-04

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 38.87  E-value: 7.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  36 SFLTWIFIPLVVMCAIYLDIFY-------IIRNKLSLNLSNSKETGAFyGREFKTAKSLFLVLFLFALSWLPLSIINCI- 107
Cdd:cd15312  170 ASLIAFFIPGTVMIGIYIKIFFvarkhakVINNRPSVTKGDSKNKLSK-KKERKAAKTLSIVMGVFLLCWLPFFVATLId 248

                         90       100       110
                 ....*....|....*....|....*....|..
gi 705043713 108 IYFNGEVPQLVLYMGILLSHANSMMNPIVYAY 139
Cdd:cd15312  249 PFLNFSTPVDLFDALVWLGYFNSTCNPLIYGF 280
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
 27-148 7.86e-04

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 38.94  E-value: 7.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  27 MRMDYMVY--FSFLTWIFIPLVVMCAIYLDIFYIIRNKLSlNLSNSKEtgafyGREFKTAKSLFLVLFLFALSWLPLSII 104
Cdd:cd15098  161 EKQQKPVYvvCTFVFGYLLPLLLITFCYAKVLNHLHKKLK-NMSKKSE-----RSKKKTAQTVLVVVVVFGISWLPHHII 234

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 705043713 105 NCIIYFnGEVP--QLVLYMGIL---LSHANSMMNPIVYAYKIKKFKETY 148
Cdd:cd15098  235 HLWVEF-GDFPltQASFVLRITahcLAYANSCVNPIIYAFLSENFRKAY 282
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
 31-138 8.33e-04

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 38.80  E-value: 8.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  31 YMVYFSFLTWiFIPLVVMCAIY-LDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIY 109
Cdd:cd15095  166 YMIYTVLLTY-VIPLAIIAVCYgLILRRLWRRSVDGNNQSEQLSERALRQKRKVTRMVIVVVVLFAICWLPNHVLNLWQR 244

                         90       100       110
                 ....*....|....*....|....*....|....
gi 705043713 110 FNGEVPQLVLYMGI-----LLSHANSMMNPIVYA 138
Cdd:cd15095  245 FDPNFPETYATYALkiaalCLSYANSAVNPFVYA 278
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
 20-148 1.48e-03

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 38.05  E-value: 1.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  20 SCQFVSVMRMDYMVYFS--FLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAfygREFKTAKSLFLVLFLFALS 97
Cdd:cd15096  153 YCTFLTEVGTAAQTFFTsfFLFSYLIPLTLICVLYMLMLRRLRRQKSPGGRRSAESQR---GKRRVTRLVVVVVVVFAIC 229

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 705043713  98 WLPLSIINCIIYFNGeVPQLVLYMGIL-----LSHANSMMNPIVYAYKIKKFKETY 148
Cdd:cd15096  230 WLPIHIILLLKYYGV-LPETVLYVVIQilsncLAYGNSCVNPILYAFLSQNFRKAF 284
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
 32-145 1.58e-03

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 38.04  E-value: 1.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  32 MVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGafyGREFKTAKSLFLVLFLFALSWLP---LSIINCII 108
Cdd:cd14970  165 FTIYTFVLGFAVPLLVITVCYSLIIRRLRSSRNLSTSGAREKR---RARRKVTRLVLVVVAVFVVCWLPfhvFQIVRLLI 241

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 705043713 109 YFN-GEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFK 145
Cdd:cd14970  242 DPPeTLTVVGVFLFCIALSYANSCLNPILYAFLDENFR 279
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
 33-148 1.59e-03

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 37.90  E-value: 1.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  33 VYFSFLTWIFIPLVVMCAIYLdiFYIIRNKLS-LNLSNSKETGAfygrEFKTAKSLFLVLFLFALSWLPLSIINCIIYFN 111
Cdd:cd15971  165 IIYTFILGFFVPLTIICLCYL--FIIIKVKSSgIRVGSSKRKKS----EKKVTRMVSIVVAVFVFCWLPFYIFNVSSVSV 238

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 705043713 112 GEVPQLVLY----MGILLSHANSMMNPIVYAYKIKKFKETY 148
Cdd:cd15971  239 SISPTPGLKgmfdFVVVLSYANSCANPILYAFLSDNFKKSF 279
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
 42-148 1.85e-03

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 37.64  E-value: 1.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  42 FIPLVVMCAIYLDIFyiirnklslnlsnsKETGafygREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGE-VPQLVLY 120
Cdd:cd17790  173 YLPVTIMIILYWRIY--------------RETI----KEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDcVPKTLWE 234

                         90       100
                 ....*....|....*....|....*...
gi 705043713 121 MGILLSHANSMMNPIVYAYKIKKFKETY 148
Cdd:cd17790  235 LGYWLCYVNSTVNPMCYALCNKSFRDTF 262
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
 25-146 2.49e-03

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 37.47  E-value: 2.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  25 SVMRMDYMVYFSFLTWiFIPLVVMCAIYLDIFYIIRNK-LSLNLSNSKETGAfygrEFKTAKSLFLVLFLFALSWLP--- 100
Cdd:cd15972  156 QVWRAGFIIYTATLGF-FCPLLVICLCYLLIVVKVRSSgRRVRATSTKRRGS----ERKVTRMVVIVVAAFVLCWLPfya 230

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 705043713 101 LSIINCIIYFNGEVPQLVLY-MGILLSHANSMMNPIVYAYKIKKFKE 146
Cdd:cd15972  231 LNIVNLVCPLPEEPSLFGLYfFVVVLSYANSCANPIIYGFLSDNFKQ 277
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
 31-146 2.94e-03

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 37.05  E-value: 2.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  31 YMVYfSFLTWIFIPLVVMCAIYLDIF-YIIRNKLSLNLSNSKEtgafygREFKTAKSLFLVLFLFALSWLPLSIINcIIY 109
Cdd:cd15088  164 FTIY-HFILGFAVPLVVITVCYILILhRLARGVAPGNQSHGSS------RTKRVTKMVILIVVVFIVCWLPFHVVQ-LVN 235

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 705043713 110 FNGEVPQLVLYMG----ILLSHANSMMNPIVYAYKIKKFKE 146
Cdd:cd15088  236 LAMNRPTLAFEVAyflsICLGYANSCLNPFVYILVSENFRK 276
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
 31-148 3.55e-03

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 36.92  E-value: 3.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  31 YMVYFSFLTWiFIPLVVMCAIYLDIFYIIRnklslnlsnsketgafygREFKTAKSLFLVLFLFALSWLPLSIINCIIYF 110
Cdd:cd15064  158 YTIFSTFGAF-YIPLLLMLILYWKIYRAAA------------------RERKAAKTLGIILGAFIVCWLPFFLVALIVPL 218

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 705043713 111 NGE--VPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETY 148
Cdd:cd15064  219 CSHcwIPLALKSFFLWLGYFNSLINPLIYTFFNKDFRKAF 258
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
 3-145 3.57e-03

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 36.71  E-value: 3.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713   3 GWNMKLTSEYHRNVTFLSCQFVSVMR--MDYMVYFSFLTWiFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYgre 80
Cdd:cd15054  139 GWHELGHERTLPNLTSGTVEGQCRLLvsLPYALVASCLTF-FLPSGAICFTYCRILLAARKALKASLTLGILLGMFF--- 214

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 705043713  81 fktakslflvlflfaLSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFK 145
Cdd:cd15054  215 ---------------VTWLPFFVANVVQAVCDCVSPGLFDVLTWLGYCNSTMNPIIYPLFMRDFK 264
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
 21-137 3.86e-03

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 36.81  E-value: 3.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  21 CQFVSvmRMDYMVYFSFLTWiFIPLVVMCAIYLDIFYIIRNKLSL-----------NLSNSKETGAFYGR--------EF 81
Cdd:cd15959  159 CDFVT--NMPYAIVSSTVSF-YVPLLVMIFVYVRVFVVATRQVRLirkdkvrfppeESPPAESRPACGRRpsrllaikEH 235

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 705043713  82 KTAKSLFLVLFLFALSWLPLSIINCIIYFNGE-VPQLVLYMGILLSHANSMMNPIVY 137
Cdd:cd15959  236 KALKTLGIIMGTFTLCWLPFFVANIIKVFCRSlVPDPAFLFLNWLGYANSAFNPIIY 292
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
 33-148 3.94e-03

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 36.76  E-value: 3.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  33 VYFSFLTWIFIPLVVMCAIYLDIFYIIRN-KLSLNLSNSKETgafygrEFKTAKSLFLVLFLFALSWLPLSIINCIIYFN 111
Cdd:cd15973  164 VIYTFLLGFLLPVLAIGLCYILIIGKMRAvALKAGWQQRRKS------EKKITRMVLMVVTVFVICWMPFYVVQLLNLFL 237

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 705043713 112 GEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETY 148
Cdd:cd15973  238 PRLDATVNHASLILSYANSCANPILYGFLSDNFRRSF 274
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
 33-138 3.94e-03

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 36.76  E-value: 3.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  33 VYFSFLTWI-------FIPLVVMCAIYLDIFYI-------IRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSW 98
Cdd:cd15055  157 VVVNFIWGVvdlvltfILPCTVMIVLYMRIFVVarsqaraIRSHTAQVSLEGSSKKVSKKSERKAAKTLGIVVGVFLLCW 236

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 705043713  99 LPLSIINcIIYFNGEVPQLVLYMGILLSHANSMMNPIVYA 138
Cdd:cd15055  237 LPYYIVS-LVDPYISTPSSVFDVLIWLGYFNSCLNPLIYA 275
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
 24-148 4.74e-03

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 36.32  E-value: 4.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  24 VSVMRMDYMVYFSFLTWiFIPLVVMCAIYLDIFYIIRNKlSLNLSNSKETGAfygrEFKTAKSLFLVLFLFALSWLPLSI 103
Cdd:cd15974  155 VSVWSTAFIIYTAVLGF-FGPLLVICLCYLLIVIKVKSS-GLRVGSTKRRKS----ERKVTRMVVIIVVVFVFCWLPFYM 228

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 705043713 104 INCI--IYFNGEVPQL--VLYMGILLSHANSMMNPIVYAYKIKKFKETY 148
Cdd:cd15974  229 LNIVnlIVILPEEPAFvgVYFFVVVLSYANSCANPILYGFLSDNFKQSF 277
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
 37-139 5.68e-03

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 36.06  E-value: 5.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  37 FLTWIFIPLVVMCAIYLDIFYIIRNK--LSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFN--G 112
Cdd:cd15207  171 FVLCYVAPLLIIAVLYVRIGYRLWFKpvPGGGSASREAQAAVSKKKVRVIKMLIVVVVLFALSWLPLHTVTMLDDFGnlS 250

                         90       100       110
                 ....*....|....*....|....*....|..
gi 705043713 113 EVPQLVLYMGI-----LLSHANSMMNPIVYAY 139
Cdd:cd15207  251 PNQREVLYVYIypiahWLAYFNSCVNPIVYGY 282
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
 1-145 6.08e-03

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 35.93  E-value: 6.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713   1 MFGWN-MKLTSEYHRNVTFLSCQFVSVMRMDYMVYfSFLTWIFIPLVVMCAIYLDIFYIIRnklslnlsnsketgafygR 79
Cdd:cd15063  136 LVGWNdGKDGIMDYSGSSSLPCTCELTNGRGYVIY-SALGSFYIPMLVMLFFYFRIYRAAR------------------M 196

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 705043713  80 EFKTAKSLFLVLFLFALSWLPLSIINCI-IYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFK 145
Cdd:cd15063  197 ETKAAKTVAIIVGCFIFCWLPFFTVYLVrAFCEDCIPPLLFSVFFWLGYCNSALNPCIYALFSRDFR 263
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
 36-139 8.08e-03

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 35.75  E-value: 8.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  36 SFLTWIFIPLVVMCAIYLDIFYI----IRNKLSL------------------NLSNSKETGAF---YGREFKTAKSLFLV 90
Cdd:cd15320  176 SSLISFYIPVAIMIVTYTRIYRIaqkqIRRISALeraavhakncqnstgnrgSGDCQQPESSFkmsFKRETKVLKTLSVI 255

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 705043713  91 LFLFALSWLPLSIINCIIYFNGE-------VPQLVLYMGILLSHANSMMNPIVYAY 139
Cdd:cd15320  256 MGVFVCCWLPFFILNCMVPFCKPtstepfcISSTTFDVFVWFGWANSSLNPIIYAF 311
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
 14-148 8.92e-03

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 35.52  E-value: 8.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  14 RNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIrNKLSLNLSNSKETGAfyGREfKTAKSLFLVLFL 93
Cdd:cd14971  147 GNRTVCSEAWPSRAHRRAFALCTFLFGYLLPLLLICVCYAAMLRHL-WRVAVRPVLSEGSRR--AKR-KVTRLVLVVVVL 222

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 705043713  94 FALSWLPLSIINCIIYFNGEVPQLVLYMGILLSH----ANSMMNPIVYAYKIKKFKETY 148
Cdd:cd14971  223 FAACWGPIHAILLLVALGPFPLTYATYALRIWAHclaySNSAVNPVLYAFLSEHFRKAF 281
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
 35-148 9.13e-03

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 35.48  E-value: 9.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705043713  35 FSFLTWI---------FIPLVVMCAIYLDIFYIIRnklslnlsnsketgafygREFKTAKSLFLVLFLFALSWLPLSIIN 105
Cdd:cd15050  158 FHDVTWFkvltailnfYIPSLLMLWFYAKIFKAVN------------------RERKAAKQLGFIMAAFILCWIPYFILF 219

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 705043713 106 CIIYF-NGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETY 148
Cdd:cd15050  220 MVIAFcKNCCNENLHMFTIWLGYINSTLNPFIYPLCNENFKKTF 263
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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