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Conserved domains on  [gi|735997387|ref|NP_001290185|]
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ATPase MORC2 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HATPase_MORC-like cd16931
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
 18-135 6.48e-63

Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.


:

Pssm-ID: 340408 [Multi-domain]  Cd Length: 118  Bit Score: 208.80  E-value: 6.48e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997387   18 YLHTNSTTHEFLFGALAELVDNARDADATRIDIYAERREDLRGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTPESTQI 97
Cdd:cd16931     1 FLHSNSTTHSWPFGAVAELVDNARDADATRLDIFIDDINLLRGGFMLSFLDDGNGMTPEEAHHMISFGFSDKRSDDHDHI 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 735997387   98 GQYGNGLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFH 135
Cdd:cd16931    81 GRYGNGFKSGSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 495-542 1.06e-16

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


:

Pssm-ID: 462181  Cd Length: 46  Bit Score: 74.65  E-value: 1.06e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 735997387   495 TTIQCDLCLKWRTLPFQLSSVEKdyPDTWVCSMNPDPEQDRCEASEQK 542
Cdd:pfam07496    1 YWVQCDSCLKWRRLPTEIDPYEL--PEPWYCSMNPDPKYNSCDAPEEI 46
Morc6_S5 super family cl39387
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 239-451 4.34e-12

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


The actual alignment was detected with superfamily member pfam17942:

Pssm-ID: 465579  Cd Length: 139  Bit Score: 64.49  E-value: 4.34e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997387   239 SFRAYAAVLY--IDPRMRIFIHGHKVQTKRLS-------CCLYKPrmykytssrfktraeqevkkaeHVARIAEEKArea 309
Cdd:pfam17942    2 SLRAYASILYlrLPPNFQIILRGKKVEHHNIAddlkypeKITYKP----------------------QVGGGKEVVV--- 56

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997387   310 eskartlEVRLGgdltrdsrvmlrqvqnraitlrreadvkkRIKEAKQralkepkeLNfVFGVNIEHRDldgmfiyncsR 389
Cdd:pfam17942   57 -------ITTIG-----------------------------FLKEAPH--------IN-VHGFNVYHKN----------R 81

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 735997387   390 LIKMYEKVGPQ-----------LEGGmacggvvgvvdvpylVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYW 451
Cdd:pfam17942   82 LIKPFWRVGNQagskgrgvigvLEAN---------------FIEPTHDKQDFERTSLYQRLEARLKQMLKEYW 139
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 620-735 4.78e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.09  E-value: 4.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997387  620 AVIRNAPSRPPSLPTPRPASQPRKAPVISSTPKLPALAAREEAstsrllqpPEAPRKPANTLVKTASRPAPLVQQLSPSL 699
Cdd:PHA03247 2726 AAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPA--------PAPPAAPAAGPPRRLTRPAVASLSESRES 2797

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 735997387  700 LPNSKSPREVPSPKVIKTPVVKKTESPIKLSPATPS 735
Cdd:PHA03247 2798 LPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTS 2833
 
Name Accession Description Interval E-value
HATPase_MORC-like cd16931
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
 18-135 6.48e-63

Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.


Pssm-ID: 340408 [Multi-domain]  Cd Length: 118  Bit Score: 208.80  E-value: 6.48e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997387   18 YLHTNSTTHEFLFGALAELVDNARDADATRIDIYAERREDLRGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTPESTQI 97
Cdd:cd16931     1 FLHSNSTTHSWPFGAVAELVDNARDADATRLDIFIDDINLLRGGFMLSFLDDGNGMTPEEAHHMISFGFSDKRSDDHDHI 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 735997387   98 GQYGNGLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFH 135
Cdd:cd16931    81 GRYGNGFKSGSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 29-169 1.69e-42

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 151.33  E-value: 1.69e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997387    29 LFGALAELVDNARDADATRIDIYAERREDlrGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTP-ESTQIGQYGNGLKSG 107
Cdd:pfam13589    1 LEGALAELIDNSIDADATNIKIEVNKNRG--GGTEIVIEDDGHGMSPEELINALRLATSAKEAKrGSTDLGRYGIGLKLA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 735997387   108 SMRIGKDFILFTKKEDTMTCLFLSRTFHEEEGiDEVIVPLPTWnartREPVTDNVEKFAIET 169
Cdd:pfam13589   79 SLSLGAKLTVTSKKEGKSSTLTLDRDKISNEN-DWLLPLLTPA----PIENFDELDKDAHGT 135
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 495-542 1.06e-16

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 74.65  E-value: 1.06e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 735997387   495 TTIQCDLCLKWRTLPFQLSSVEKdyPDTWVCSMNPDPEQDRCEASEQK 542
Cdd:pfam07496    1 YWVQCDSCLKWRRLPTEIDPYEL--PEPWYCSMNPDPKYNSCDAPEEI 46
Morc6_S5 pfam17942
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 239-451 4.34e-12

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


Pssm-ID: 465579  Cd Length: 139  Bit Score: 64.49  E-value: 4.34e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997387   239 SFRAYAAVLY--IDPRMRIFIHGHKVQTKRLS-------CCLYKPrmykytssrfktraeqevkkaeHVARIAEEKArea 309
Cdd:pfam17942    2 SLRAYASILYlrLPPNFQIILRGKKVEHHNIAddlkypeKITYKP----------------------QVGGGKEVVV--- 56

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997387   310 eskartlEVRLGgdltrdsrvmlrqvqnraitlrreadvkkRIKEAKQralkepkeLNfVFGVNIEHRDldgmfiyncsR 389
Cdd:pfam17942   57 -------ITTIG-----------------------------FLKEAPH--------IN-VHGFNVYHKN----------R 81

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 735997387   390 LIKMYEKVGPQ-----------LEGGmacggvvgvvdvpylVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYW 451
Cdd:pfam17942   82 LIKPFWRVGNQagskgrgvigvLEAN---------------FIEPTHDKQDFERTSLYQRLEARLKQMLKEYW 139
PHA03247 PHA03247
large tegument protein UL36; Provisional
 620-735 4.78e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.09  E-value: 4.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997387  620 AVIRNAPSRPPSLPTPRPASQPRKAPVISSTPKLPALAAREEAstsrllqpPEAPRKPANTLVKTASRPAPLVQQLSPSL 699
Cdd:PHA03247 2726 AAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPA--------PAPPAAPAAGPPRRLTRPAVASLSESRES 2797

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 735997387  700 LPNSKSPREVPSPKVIKTPVVKKTESPIKLSPATPS 735
Cdd:PHA03247 2798 LPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTS 2833
MutL COG0323
DNA mismatch repair ATPase MutL [Replication, recombination and repair];
35-79 7.16e-04

DNA mismatch repair ATPase MutL [Replication, recombination and repair];


Pssm-ID: 440092 [Multi-domain]  Cd Length: 515  Bit Score: 43.49  E-value: 7.16e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 735997387   35 ELVDNARDADATRIDIYAErredlRGGFML-CFLDDGAGMDPSDAA 79
Cdd:COG0323    30 ELVENAIDAGATRIEVEIE-----EGGKSLiRVTDNGCGMSPEDLP 70
mutL PRK00095
DNA mismatch repair endonuclease MutL;
35-79 1.69e-03

DNA mismatch repair endonuclease MutL;


Pssm-ID: 234630 [Multi-domain]  Cd Length: 617  Bit Score: 42.13  E-value: 1.69e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 735997387   35 ELVDNARDADATRIDIYAErredlRGGfmlcfL------DDGAGMDPSDAA 79
Cdd:PRK00095   29 ELVENALDAGATRIDIEIE-----EGG-----LklirvrDNGCGISKEDLA 69
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 32-104 6.30e-03

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 37.63  E-value: 6.30e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 735997387     32 ALAELVDNARDA--DATRIDIYAERREDlrgGFMLCFLDDGAGMDPSDAASViqFGKSAKRTPESTQIGQYGNGL 104
Cdd:smart00387    9 VLSNLLDNAIKYtpEGGRITVTLERDGD---HVEITVEDNGPGIPPEDLEKI--FEPFFRTDKRSRKIGGTGLGL 78
PTZ00121 PTZ00121
MAEBL; Provisional
 285-364 6.60e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.51  E-value: 6.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997387  285 KTRAEQEVKKAEHVARIAEEKAREAESKARTLEVRLGGDLTRDSrvmlrQVQNRAITLRREADVKKRIKEAKQRALKEPK 364
Cdd:PTZ00121 1397 KKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKA-----EEAKKADEAKKKAEEAKKAEEAKKKAEEAKK 1471
 
Name Accession Description Interval E-value
HATPase_MORC-like cd16931
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
 18-135 6.48e-63

Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.


Pssm-ID: 340408 [Multi-domain]  Cd Length: 118  Bit Score: 208.80  E-value: 6.48e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997387   18 YLHTNSTTHEFLFGALAELVDNARDADATRIDIYAERREDLRGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTPESTQI 97
Cdd:cd16931     1 FLHSNSTTHSWPFGAVAELVDNARDADATRLDIFIDDINLLRGGFMLSFLDDGNGMTPEEAHHMISFGFSDKRSDDHDHI 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 735997387   98 GQYGNGLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFH 135
Cdd:cd16931    81 GRYGNGFKSGSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 29-169 1.69e-42

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 151.33  E-value: 1.69e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997387    29 LFGALAELVDNARDADATRIDIYAERREDlrGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTP-ESTQIGQYGNGLKSG 107
Cdd:pfam13589    1 LEGALAELIDNSIDADATNIKIEVNKNRG--GGTEIVIEDDGHGMSPEELINALRLATSAKEAKrGSTDLGRYGIGLKLA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 735997387   108 SMRIGKDFILFTKKEDTMTCLFLSRTFHEEEGiDEVIVPLPTWnartREPVTDNVEKFAIET 169
Cdd:pfam13589   79 SLSLGAKLTVTSKKEGKSSTLTLDRDKISNEN-DWLLPLLTPA----PIENFDELDKDAHGT 135
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 495-542 1.06e-16

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 74.65  E-value: 1.06e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 735997387   495 TTIQCDLCLKWRTLPFQLSSVEKdyPDTWVCSMNPDPEQDRCEASEQK 542
Cdd:pfam07496    1 YWVQCDSCLKWRRLPTEIDPYEL--PEPWYCSMNPDPKYNSCDAPEEI 46
Morc6_S5 pfam17942
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 239-451 4.34e-12

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


Pssm-ID: 465579  Cd Length: 139  Bit Score: 64.49  E-value: 4.34e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997387   239 SFRAYAAVLY--IDPRMRIFIHGHKVQTKRLS-------CCLYKPrmykytssrfktraeqevkkaeHVARIAEEKArea 309
Cdd:pfam17942    2 SLRAYASILYlrLPPNFQIILRGKKVEHHNIAddlkypeKITYKP----------------------QVGGGKEVVV--- 56

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997387   310 eskartlEVRLGgdltrdsrvmlrqvqnraitlrreadvkkRIKEAKQralkepkeLNfVFGVNIEHRDldgmfiyncsR 389
Cdd:pfam17942   57 -------ITTIG-----------------------------FLKEAPH--------IN-VHGFNVYHKN----------R 81

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 735997387   390 LIKMYEKVGPQ-----------LEGGmacggvvgvvdvpylVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYW 451
Cdd:pfam17942   82 LIKPFWRVGNQagskgrgvigvLEAN---------------FIEPTHDKQDFERTSLYQRLEARLKQMLKEYW 139
PHA03247 PHA03247
large tegument protein UL36; Provisional
 620-735 4.78e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.09  E-value: 4.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997387  620 AVIRNAPSRPPSLPTPRPASQPRKAPVISSTPKLPALAAREEAstsrllqpPEAPRKPANTLVKTASRPAPLVQQLSPSL 699
Cdd:PHA03247 2726 AAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPA--------PAPPAAPAAGPPRRLTRPAVASLSESRES 2797

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 735997387  700 LPNSKSPREVPSPKVIKTPVVKKTESPIKLSPATPS 735
Cdd:PHA03247 2798 LPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTS 2833
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 633-739 5.59e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 47.38  E-value: 5.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997387  633 PTPRPASQPRKAPVISSTPKLPalaareeaSTSRLLQPPEAPRKPAN--TLVKTASRPAPLVQQL-----SPSLLPNSKS 705
Cdd:PTZ00449  561 PGPAKEHKPSKIPTLSKKPEFP--------KDPKHPKDPEEPKKPKRprSAQRPTRPKSPKLPELldipkSPKRPESPKS 632

                          90       100       110
                  ....*....|....*....|....*....|....
gi 735997387  706 PREVPSPKVIKTPvvKKTESPikLSPATPSRKRS 739
Cdd:PTZ00449  633 PKRPPPPQRPSSP--ERPEGP--KIIKSPKPPKS 662
HATPase_MutL-MLH-PMS-like cd16926
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, ...
 35-83 1.30e-04

Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of Escherichia coli MutL, human MLH1 (mutL homolog 1), human PMS1 (PMS1 homolog 1, mismatch repair system component), human MLH3 (mutL homolog 3), and human PMS2 (PMS1 homolog 2, mismatch repair system component). MutL homologs (MLH/PMS) participate in MMR (DNA mismatch repair), and in addition have role(s) in DNA damage signaling and suppression of homologous recombination (recombination between partially homologous parental DNAs). The primary role of MutL in MMR is to mediate protein-protein interactions during mismatch recognition and strand removal; a ternary complex is formed between MutS, MutL, and the mismatched DNA, which activates the MutH endonuclease.


Pssm-ID: 340403 [Multi-domain]  Cd Length: 188  Bit Score: 43.96  E-value: 1.30e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 735997387   35 ELVDNARDADATRIDIYAErredlRGGfmLCFL---DDGAGMDPSDAASVIQ 83
Cdd:cd16926    20 ELVENSIDAGATRIDVEIE-----EGG--LKLIrvtDNGSGISREDLELAFE 64
PHA03247 PHA03247
large tegument protein UL36; Provisional
 624-738 1.60e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 1.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997387  624 NAPSRPPSLPTPrPASQPRKAPVISSTPKLPALA------AREEASTSRLLQPPEAPRKPANTLVKTASRPAPLV----- 692
Cdd:PHA03247 2755 ARPARPPTTAGP-PAPAPPAAPAAGPPRRLTRPAvaslseSRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLpppts 2833

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 735997387  693 -QQLSPSLLPNSKSPREVPSPKVIKTPVVKK--TESPIKLSPATPSRKR 738
Cdd:PHA03247 2834 aQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRrpPSRSPAAKPAAPARPP 2882
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 625-740 2.47e-04

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 44.08  E-value: 2.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997387  625 APSRPPSLPTPRPASQPRKAPVISSTPKLPALAAREEASTSRLLQPPEAPRKPANTLVKtASRPAPLVQQLSPSLLPNSK 704
Cdd:PHA02682  102 APAPAVTCPAPAPACPPATAPTCPPPAVCPAPARPAPACPPSTRQCPPAPPLPTPKPAP-AAKPIFLHNQLPPPDYPAAS 180

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 735997387  705 SPREVPSPKVikTPVVkKTESPIKLSPATPSRKRSV 740
Cdd:PHA02682  181 CPTIETAPAA--SPVL-EPRIPDKIIDADNDDKDLI 213
PHA03247 PHA03247
large tegument protein UL36; Provisional
 625-734 2.61e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 2.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997387  625 APSRPPSLPTPRPASQPRKAPVISSTPKLPALA-----------AREEASTSRLLQPPEAPRKPantlvktASRP--APL 691
Cdd:PHA03247 2623 APDPPPPSPSPAANEPDPHPPPTVPPPERPRDDpapgrvsrprrARRLGRAAQASSPPQRPRRR-------AARPtvGSL 2695

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 735997387  692 VQQLSPSllPNSKSPREVPSPKVIKTPVVKKTESPIKLSPATP 734
Cdd:PHA03247 2696 TSLADPP--PPPPTPEPAPHALVSATPLPPGPAAARQASPALP 2736
PHA03247 PHA03247
large tegument protein UL36; Provisional
 596-741 3.94e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 3.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997387  596 EVTTRPSTEEPVRRPQRPRSPPLPAVIRNAPSRPP-SLPTPRPASQPRKAPvisSTPKLPALAAREEASTSRLLQPPEAP 674
Cdd:PHA03247 2861 DVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTeSFALPPDQPERPPQP---QAPPPPQPQPQPPPPPQPQPPPPPPP 2937

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 735997387  675 RKPANTLVKTASRPAPLVQQLSPSLLPNSKSPREVPSPKVIKTPVVKKTESPiklSPATPSRKRSVA 741
Cdd:PHA03247 2938 RPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAP---ASSTPPLTGHSL 3001
MutL COG0323
DNA mismatch repair ATPase MutL [Replication, recombination and repair];
35-79 7.16e-04

DNA mismatch repair ATPase MutL [Replication, recombination and repair];


Pssm-ID: 440092 [Multi-domain]  Cd Length: 515  Bit Score: 43.49  E-value: 7.16e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 735997387   35 ELVDNARDADATRIDIYAErredlRGGFML-CFLDDGAGMDPSDAA 79
Cdd:COG0323    30 ELVENAIDAGATRIEVEIE-----EGGKSLiRVTDNGCGMSPEDLP 70
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 625-735 1.51e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.39  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997387  625 APSRPPSLPT-PRPASQPRKAPVISSTPKLPALAAREEASTSrLLQPPEAPRKPANTLVKTASRPAplvqqlSPSLLPNS 703
Cdd:PRK14951  376 AEKKTPARPEaAAPAAAPVAQAAAAPAPAAAPAAAASAPAAP-PAAAPPAPVAAPAAAAPAAAPAA------APAAVALA 448

                          90       100       110
                  ....*....|....*....|....*....|..
gi 735997387  704 KSPREVPSPKVIKTPVVKKTESPIKLSPATPS 735
Cdd:PRK14951  449 PAPPAQAAPETVAIPVRVAPEPAVASAAPAPA 480
mutL PRK00095
DNA mismatch repair endonuclease MutL;
35-79 1.69e-03

DNA mismatch repair endonuclease MutL;


Pssm-ID: 234630 [Multi-domain]  Cd Length: 617  Bit Score: 42.13  E-value: 1.69e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 735997387   35 ELVDNARDADATRIDIYAErredlRGGfmlcfL------DDGAGMDPSDAA 79
Cdd:PRK00095   29 ELVENALDAGATRIDIEIE-----EGG-----LklirvrDNGCGISKEDLA 69
PHA03247 PHA03247
large tegument protein UL36; Provisional
 623-735 2.06e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 2.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997387  623 RNAPSrPPSLPTPRPASQPRKAPVISSTPKLPA-LAAREE-ASTSRLLQPPEAPRKPANTLVKTASR-PAPLVQQLSPSL 699
Cdd:PHA03247 2653 RDDPA-PGRVSRPRRARRLGRAAQASSPPQRPRrRAARPTvGSLTSLADPPPPPPTPEPAPHALVSAtPLPPGPAAARQA 2731

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 735997387  700 LPnsKSPREVPSPKVIKTPVVKKTESPIKlSPATPS 735
Cdd:PHA03247 2732 SP--ALPAAPAPPAVPAGPATPGGPARPA-RPPTTA 2764
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 624-731 2.29e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 41.84  E-value: 2.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997387  624 NAPSRPPSLPTPRPASQPRKAPVISSTPKLPALAAREE------ASTSRL--------LQPPEAPRKPANTLVKTASRPA 689
Cdd:PLN03209  322 KIPSQRVPPKESDAADGPKPVPTKPVTPEAPSPPIEEEppqpkaVVPRPLspytayedLKPPTSPIPTPPSSSPASSKSV 401

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 735997387  690 PLVQQL-SPSLLPNSKSPREVPSPKVIktPVVKKTESPikLSP 731
Cdd:PLN03209  402 DAVAKPaEPDVVPSPGSASNVPEVEPA--QVEAKKTRP--LSP 440
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 32-104 6.30e-03

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 37.63  E-value: 6.30e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 735997387     32 ALAELVDNARDA--DATRIDIYAERREDlrgGFMLCFLDDGAGMDPSDAASViqFGKSAKRTPESTQIGQYGNGL 104
Cdd:smart00387    9 VLSNLLDNAIKYtpEGGRITVTLERDGD---HVEITVEDNGPGIPPEDLEKI--FEPFFRTDKRSRKIGGTGLGL 78
PTZ00121 PTZ00121
MAEBL; Provisional
 285-364 6.60e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.51  E-value: 6.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997387  285 KTRAEQEVKKAEHVARIAEEKAREAESKARTLEVRLGGDLTRDSrvmlrQVQNRAITLRREADVKKRIKEAKQRALKEPK 364
Cdd:PTZ00121 1397 KKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKA-----EEAKKADEAKKKAEEAKKAEEAKKKAEEAKK 1471
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 621-722 6.65e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.44  E-value: 6.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997387  621 VIRNAPSRPPSLPTPRPASQPR--KAPVISSTPKLPALAAREEastsrLLQPPEAPRKPANTlvKTASRPAPLVQQLSPS 698
Cdd:PTZ00449  574 TLSKKPEFPKDPKHPKDPEEPKkpKRPRSAQRPTRPKSPKLPE-----LLDIPKSPKRPESP--KSPKRPPPPQRPSSPE 646

                          90       100
                  ....*....|....*....|....*...
gi 735997387  699 LlPNS----KSPREVPSPKVIKTPVVKK 722
Cdd:PTZ00449  647 R-PEGpkiiKSPKPPKSPKPPFDPKFKE 673
PHA03247 PHA03247
large tegument protein UL36; Provisional
 625-744 8.33e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 8.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997387  625 APSRPP-----SLPTPRPASQPRKAPVIS--STPKLPALAAREEA----STSRLLQPPEAPRKPANT-LVKTASRPAPLV 692
Cdd:PHA03247 2556 PPAAPPaapdrSVPPPRPAPRPSEPAVTSraRRPDAPPQSARPRApvddRGDPRGPAPPSPLPPDTHaPDPPPPSPSPAA 2635

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 735997387  693 QQL---SPSLLPNSKSPREVPSPKVIKTPVVKKTESPIKLSPATPSRKRSVAVSD 744
Cdd:PHA03247 2636 NEPdphPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARP 2690
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 625-710 9.20e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.08  E-value: 9.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997387  625 APSRPPSLPTPRPASQPRKAPVISSTPKLPALAAREEAStsrllqPPEAPRKPANTLVKTASRPAPLVQQLSPSLLPNSK 704
Cdd:PRK14951  413 APAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAP------PAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAA 486


                  ....*.
gi 735997387  705 SPREVP 710
Cdd:PRK14951  487 RLTPTE 492
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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