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Conserved domains on  [gi|742799281|ref|NP_001290380|]
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kelch-like protein 36 isoform 2 [Homo sapiens]

Protein Classification

Kelch-like protein 36( domain architecture ID 13033255)

Kelch-like protein 36 (KLHL36) is a probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-155 4.42e-97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 291.02  E-value: 4.42e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  21 KVYRWADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAV 100
Cdd:cd18266    1 KVYRWADHSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIGLKAV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 742799281 101 VDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNYLYLQELA 155
Cdd:cd18266   81 IDFLYSSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEENYLYLQELA 135
BACK_KLHL36 cd18475
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act ...
 143-242 7.22e-66

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


:

Pssm-ID: 350550  Cd Length: 100  Bit Score: 208.93  E-value: 7.22e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 143 VSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQQP 222
Cdd:cd18475    1 VSEENYLYLQELASIYSLERLDSFIDSFILQNFGTLSFTPDFLQNVSMQKLCQYLSSNQVQHECEHDLLQAALQWLTQSP 80

                         90       100
                 ....*....|....*....|
gi 742799281 223 EREAHARQVLENIHFPLIPK 242
Cdd:cd18475   81 ERENEAYQVLSNIHFPLIPK 100
PHA03098 super family cl33709
kelch-like protein; Provisional
 45-522 6.77e-33

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 132.20  E-value: 6.77e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  45 FCD--VVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREafqKEVELIGaSYIGLKAVVDFLYGGELVLDGGNIDYVLET 122
Cdd:PHA03098   9 FCDesIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKE---NEINLNI-DYDSFNEVIKYIYTGKINITSNNVKDILSI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 123 AHLLQIWTVVDFCCEYLEQEVSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLqNVSMQKLCVYLSSSEV 202
Cdd:PHA03098  85 ANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFI-YLSKNELIKILSDDKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 203 QRECEHDLLQAALQWLT-QQPEREAHARQVLENIHFPLIP-------KNDLLHRVKP-------AVCSLLPKEANC---- 263
Cdd:PHA03098 164 NVSSEDVVLEIIIKWLTsKKNNKYKDICLILKVLRITFLSeegikklKRWKLRIKKKkivfnkrCIKIIYSKKYNLnkil 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 264 --------EGFIEEAVRY-HNNLAAQPVMQTKRTALRTNQER-----------LLFVGGevSERCLELSDDTCYLDAKSE 323
Cdd:PHA03098 244 prsstfgsIIYIHITMSIfTYNYITNYSPLSEINTIIDIHYVycfgsvvlnnvIYFIGG--MNKNNLSVNSVVSYDTKTK 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 324 QWVKETPLPARRSHHCVAVLGGFIFIAGGsfsRDNGGDAASNLLYRFT--------------YGHAGTIYKDFVYISGGh 389
Cdd:PHA03098 322 SWNKVPELIYPRKNPGVTVFNNRIYVIGG---IYNSISLNTVESWKPGeskwreepplifprYNPCVVNVNNLIYVIGG- 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 390 DYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDdNIESMERFDVlgVEAYSPQCNQWTRVAPL 469
Cdd:PHA03098 398 ISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIS-YIDNIKVYNI--VESYNPVTNKWTELSSL 474

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|...
gi 742799281 470 LHANSESGVAVWEGRIYILGGYSweNTAFSKTVQVYDREADKWSRGVDLPKAI 522
Cdd:PHA03098 475 NFPRINASLCIFNNKIYVVGGDK--YEYYINEIEVYDDKTNTWTLFCKFPKVI 525
 
Name Accession Description Interval E-value
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-155 4.42e-97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 291.02  E-value: 4.42e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  21 KVYRWADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAV 100
Cdd:cd18266    1 KVYRWADHSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIGLKAV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 742799281 101 VDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNYLYLQELA 155
Cdd:cd18266   81 IDFLYSSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEENYLYLQELA 135
BACK_KLHL36 cd18475
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act ...
 143-242 7.22e-66

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350550  Cd Length: 100  Bit Score: 208.93  E-value: 7.22e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 143 VSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQQP 222
Cdd:cd18475    1 VSEENYLYLQELASIYSLERLDSFIDSFILQNFGTLSFTPDFLQNVSMQKLCQYLSSNQVQHECEHDLLQAALQWLTQSP 80

                         90       100
                 ....*....|....*....|
gi 742799281 223 EREAHARQVLENIHFPLIPK 242
Cdd:cd18475   81 ERENEAYQVLSNIHFPLIPK 100
PHA03098 PHA03098
kelch-like protein; Provisional
 45-522 6.77e-33

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 132.20  E-value: 6.77e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  45 FCD--VVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREafqKEVELIGaSYIGLKAVVDFLYGGELVLDGGNIDYVLET 122
Cdd:PHA03098   9 FCDesIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKE---NEINLNI-DYDSFNEVIKYIYTGKINITSNNVKDILSI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 123 AHLLQIWTVVDFCCEYLEQEVSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLqNVSMQKLCVYLSSSEV 202
Cdd:PHA03098  85 ANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFI-YLSKNELIKILSDDKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 203 QRECEHDLLQAALQWLT-QQPEREAHARQVLENIHFPLIP-------KNDLLHRVKP-------AVCSLLPKEANC---- 263
Cdd:PHA03098 164 NVSSEDVVLEIIIKWLTsKKNNKYKDICLILKVLRITFLSeegikklKRWKLRIKKKkivfnkrCIKIIYSKKYNLnkil 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 264 --------EGFIEEAVRY-HNNLAAQPVMQTKRTALRTNQER-----------LLFVGGevSERCLELSDDTCYLDAKSE 323
Cdd:PHA03098 244 prsstfgsIIYIHITMSIfTYNYITNYSPLSEINTIIDIHYVycfgsvvlnnvIYFIGG--MNKNNLSVNSVVSYDTKTK 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 324 QWVKETPLPARRSHHCVAVLGGFIFIAGGsfsRDNGGDAASNLLYRFT--------------YGHAGTIYKDFVYISGGh 389
Cdd:PHA03098 322 SWNKVPELIYPRKNPGVTVFNNRIYVIGG---IYNSISLNTVESWKPGeskwreepplifprYNPCVVNVNNLIYVIGG- 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 390 DYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDdNIESMERFDVlgVEAYSPQCNQWTRVAPL 469
Cdd:PHA03098 398 ISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIS-YIDNIKVYNI--VESYNPVTNKWTELSSL 474

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|...
gi 742799281 470 LHANSESGVAVWEGRIYILGGYSweNTAFSKTVQVYDREADKWSRGVDLPKAI 522
Cdd:PHA03098 475 NFPRINASLCIFNNKIYVVGGDK--YEYYINEIEVYDDKTNTWTLFCKFPKVI 525
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 36-141 8.20e-32

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 118.51  E-value: 8.20e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281   36 LNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGELVlDGGN 115
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKLI-SEEN 79

                          90       100
                  ....*....|....*....|....*.
gi 742799281  116 IDYVLETAHLLQIWTVVDFCCEYLEQ 141
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIK 105
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
281-529 3.42e-30

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 119.49  E-value: 3.42e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 281 PVMQTKR--TALRTNQERLLFVGGEVSERCLelsdDTCY-LDAKSEQWVKETPLP-ARRSHHCVAVLGGFIFIAGGsFSR 356
Cdd:COG3055    7 PDLPTPRseAAAALLDGKVYVAGGLSGGSAS----NSFEvYDPATNTWSELAPLPgPPRHHAAAVAQDGKLYVFGG-FTG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 357 DNGGDAASNLLYRFT----------------YGHAGTIYKDFVYISGGHDYqiGPYRKNLLCYDHRTDVWEERRPMTTAR 420
Cdd:COG3055   82 ANPSSTPLNDVYVYDpatntwtklapmptprGGATALLLDGKIYVVGGWDD--GGNVAWVEVYDPATGTWTQLAPLPTPR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 421 GWHS-MCSLGDSIYSIGGSDDNIESmerfdvlgveayspqcNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWentaFS 499
Cdd:COG3055  160 DHLAaAVLPDGKILVIGGRNGSGFS----------------NTWTTLAPLPTARAGHAAAVLGGKILVFGGESG----FS 219

                        250       260       270
                 ....*....|....*....|....*....|
gi 742799281 500 KTVQVYDREADKWSRGVDLPKAIAGGSACV 529
Cdd:COG3055  220 DEVEAYDPATNTWTALGELPTPRHGHAAVL 249
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 47-141 2.11e-24

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 97.38  E-value: 2.11e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281    47 DVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLL 126
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*
gi 742799281   127 QIWTVVDFCCEYLEQ 141
Cdd:smart00225  81 QIPGLVELCEEFLLK 95
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 149-250 1.88e-23

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 94.92  E-value: 1.88e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  149 LYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQnVSMQKLCVYLSSSEVQRECEHDLLQAALQWLT-QQPEREAH 227
Cdd:pfam07707   2 LGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLE-LSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKhDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 742799281  228 ARQVLENIHFPLIPKNDLLHRVK 250
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 148-248 3.83e-21

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 88.17  E-value: 3.83e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281   148 YLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQnVSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQQPE-REA 226
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLE-LPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEkRRE 79

                           90       100
                   ....*....|....*....|..
gi 742799281   227 HARQVLENIHFPLIPKNDLLHR 248
Cdd:smart00875  80 HLPELLEHVRLPLLSPDYLLEV 101
Kelch smart00612
Kelch domain;
484-530 5.71e-08

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 49.09  E-value: 5.71e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 742799281   484 RIYILGGYSweNTAFSKTVQVYDREADKWSRGVDLPKAIAGGSACVC 530
Cdd:smart00612   1 KIYVVGGFD--GGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 474-519 6.38e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 43.37  E-value: 6.38e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 742799281  474 SESGVAVWEGRIYILGGYSWENtaFSKTVQVYDREADKWSRGVDLP 519
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFDGNQ--SLNSVEVYDPETNTWSKLPSMP 46
 
Name Accession Description Interval E-value
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-155 4.42e-97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 291.02  E-value: 4.42e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  21 KVYRWADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAV 100
Cdd:cd18266    1 KVYRWADHSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIGLKAV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 742799281 101 VDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNYLYLQELA 155
Cdd:cd18266   81 IDFLYSSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEENYLYLQELA 135
BACK_KLHL36 cd18475
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act ...
 143-242 7.22e-66

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350550  Cd Length: 100  Bit Score: 208.93  E-value: 7.22e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 143 VSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQQP 222
Cdd:cd18475    1 VSEENYLYLQELASIYSLERLDSFIDSFILQNFGTLSFTPDFLQNVSMQKLCQYLSSNQVQHECEHDLLQAALQWLTQSP 80

                         90       100
                 ....*....|....*....|
gi 742799281 223 EREAHARQVLENIHFPLIPK 242
Cdd:cd18475   81 ERENEAYQVLSNIHFPLIPK 100
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-147 1.64e-39

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 139.84  E-value: 1.64e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGG 107
Cdd:cd18255    1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTS 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 742799281 108 ELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147
Cdd:cd18255   81 ELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVEN 120
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-147 8.57e-34

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 124.53  E-value: 8.57e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADE--QRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLY 105
Cdd:cd18239    6 HSSVVLQGFDQLRGEGLLCDVTLVPGDgdETFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGLKNIIDFIY 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 742799281 106 GGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147
Cdd:cd18239   86 TAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLEN 127
PHA03098 PHA03098
kelch-like protein; Provisional
 45-522 6.77e-33

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 132.20  E-value: 6.77e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  45 FCD--VVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREafqKEVELIGaSYIGLKAVVDFLYGGELVLDGGNIDYVLET 122
Cdd:PHA03098   9 FCDesIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKE---NEINLNI-DYDSFNEVIKYIYTGKINITSNNVKDILSI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 123 AHLLQIWTVVDFCCEYLEQEVSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLqNVSMQKLCVYLSSSEV 202
Cdd:PHA03098  85 ANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFI-YLSKNELIKILSDDKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 203 QRECEHDLLQAALQWLT-QQPEREAHARQVLENIHFPLIP-------KNDLLHRVKP-------AVCSLLPKEANC---- 263
Cdd:PHA03098 164 NVSSEDVVLEIIIKWLTsKKNNKYKDICLILKVLRITFLSeegikklKRWKLRIKKKkivfnkrCIKIIYSKKYNLnkil 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 264 --------EGFIEEAVRY-HNNLAAQPVMQTKRTALRTNQER-----------LLFVGGevSERCLELSDDTCYLDAKSE 323
Cdd:PHA03098 244 prsstfgsIIYIHITMSIfTYNYITNYSPLSEINTIIDIHYVycfgsvvlnnvIYFIGG--MNKNNLSVNSVVSYDTKTK 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 324 QWVKETPLPARRSHHCVAVLGGFIFIAGGsfsRDNGGDAASNLLYRFT--------------YGHAGTIYKDFVYISGGh 389
Cdd:PHA03098 322 SWNKVPELIYPRKNPGVTVFNNRIYVIGG---IYNSISLNTVESWKPGeskwreepplifprYNPCVVNVNNLIYVIGG- 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 390 DYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDdNIESMERFDVlgVEAYSPQCNQWTRVAPL 469
Cdd:PHA03098 398 ISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIS-YIDNIKVYNI--VESYNPVTNKWTELSSL 474

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|...
gi 742799281 470 LHANSESGVAVWEGRIYILGGYSweNTAFSKTVQVYDREADKWSRGVDLPKAI 522
Cdd:PHA03098 475 NFPRINASLCIFNNKIYVVGGDK--YEYYINEIEVYDDKTNTWTLFCKFPKVI 525
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-149 2.18e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 120.84  E-value: 2.18e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGG 107
Cdd:cd18261   11 HKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQALDFAYTG 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 742799281 108 ELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNYL 149
Cdd:cd18261   91 QILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFNYL 132
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 36-141 8.20e-32

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 118.51  E-value: 8.20e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281   36 LNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGELVlDGGN 115
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKLI-SEEN 79

                          90       100
                  ....*....|....*....|....*.
gi 742799281  116 IDYVLETAHLLQIWTVVDFCCEYLEQ 141
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIK 105
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
281-529 3.42e-30

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 119.49  E-value: 3.42e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 281 PVMQTKR--TALRTNQERLLFVGGEVSERCLelsdDTCY-LDAKSEQWVKETPLP-ARRSHHCVAVLGGFIFIAGGsFSR 356
Cdd:COG3055    7 PDLPTPRseAAAALLDGKVYVAGGLSGGSAS----NSFEvYDPATNTWSELAPLPgPPRHHAAAVAQDGKLYVFGG-FTG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 357 DNGGDAASNLLYRFT----------------YGHAGTIYKDFVYISGGHDYqiGPYRKNLLCYDHRTDVWEERRPMTTAR 420
Cdd:COG3055   82 ANPSSTPLNDVYVYDpatntwtklapmptprGGATALLLDGKIYVVGGWDD--GGNVAWVEVYDPATGTWTQLAPLPTPR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 421 GWHS-MCSLGDSIYSIGGSDDNIESmerfdvlgveayspqcNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWentaFS 499
Cdd:COG3055  160 DHLAaAVLPDGKILVIGGRNGSGFS----------------NTWTTLAPLPTARAGHAAAVLGGKILVFGGESG----FS 219

                        250       260       270
                 ....*....|....*....|....*....|
gi 742799281 500 KTVQVYDREADKWSRGVDLPKAIAGGSACV 529
Cdd:COG3055  220 DEVEAYDPATNTWTALGELPTPRHGHAAVL 249
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-141 2.62e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 111.60  E-value: 2.62e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  27 DHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYG 106
Cdd:cd18247    1 DLPSSGFPVMEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYS 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 742799281 107 GELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQ 141
Cdd:cd18247   81 GRIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKE 115
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-147 2.89e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 109.07  E-value: 2.89e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGG 107
Cdd:cd18242    4 HAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYTE 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 742799281 108 ELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147
Cdd:cd18242   84 TVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSN 123
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-147 7.07e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 105.29  E-value: 7.07e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  23 YRWADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVD 102
Cdd:cd18251    1 YRSVAHSQALLDGLVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCKILD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 742799281 103 FLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147
Cdd:cd18251   81 FIYTSELELSLDNVQETLTAACQLQIPEVIGFCCDFLMSWVDNEN 125
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-149 3.78e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 99.75  E-value: 3.78e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  46 CDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHL 125
Cdd:cd18234    2 CDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATACL 81

                         90       100
                 ....*....|....*....|....
gi 742799281 126 LQIWTVVDFCCEYLEQEVSEDNYL 149
Cdd:cd18234   82 LQLSEVVEACCGFLMKQLHPSNCL 105
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-140 4.58e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 100.19  E-value: 4.58e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  27 DHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYG 106
Cdd:cd18235    3 QHTQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVYT 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 742799281 107 GELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLE 140
Cdd:cd18235   83 AEIQVTEENVQVLLPAANLLQLTDVRDACCDFLQ 116
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-126 4.89e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 98.78  E-value: 4.89e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  45 FCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAH 124
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAAD 80


                 ..
gi 742799281 125 LL 126
Cdd:cd18186   81 KL 82
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-147 1.55e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 98.75  E-value: 1.55e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGG 107
Cdd:cd18253    1 HSESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 742799281 108 ELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147
Cdd:cd18253   81 KVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCN 120
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-140 1.63e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 98.47  E-value: 1.63e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  27 DHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYG 106
Cdd:cd18326    7 DHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTALLDFAYT 86

                         90       100       110
                 ....*....|....*....|....*....|....
gi 742799281 107 GELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLE 140
Cdd:cd18326   87 ATLTVSTSNVGDILSAARLLEIPAVSHVCADLLD 120
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 47-141 2.11e-24

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 97.38  E-value: 2.11e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281    47 DVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLL 126
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*
gi 742799281   127 QIWTVVDFCCEYLEQ 141
Cdd:smart00225  81 QIPGLVELCEEFLLK 95
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-149 3.68e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 97.56  E-value: 3.68e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  26 ADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLY 105
Cdd:cd18237    2 AKLLADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAY 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 742799281 106 GGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNYL 149
Cdd:cd18237   82 TARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCL 125
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-140 4.21e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 97.24  E-value: 4.21e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  27 DHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYG 106
Cdd:cd18198    7 DHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSPEALTALLEFAYT 86

                         90       100       110
                 ....*....|....*....|....*....|....
gi 742799281 107 GELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLE 140
Cdd:cd18198   87 ATLTVSTANVGDILSAARLLEIPCVSHVCAEILD 120
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-143 4.58e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 97.22  E-value: 4.58e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGG 107
Cdd:cd18257    1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTG 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 742799281 108 ELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEV 143
Cdd:cd18257   81 TVFISQATVESLLPAANLLQIKLVLKECCDFLESQL 116
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-147 1.73e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 95.47  E-value: 1.73e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  29 SSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGE 108
Cdd:cd18240    1 SAMACNVFNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAYTRT 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 742799281 109 LVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147
Cdd:cd18240   81 VPITAENVEELLPAADQFNIMGIVKACCDFLEDQLCPEN 119
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 149-250 1.88e-23

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 94.92  E-value: 1.88e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  149 LYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQnVSMQKLCVYLSSSEVQRECEHDLLQAALQWLT-QQPEREAH 227
Cdd:pfam07707   2 LGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLE-LSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKhDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 742799281  228 ARQVLENIHFPLIPKNDLLHRVK 250
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-149 3.22e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 95.22  E-value: 3.22e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGG 107
Cdd:cd18265    6 HAERILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYGG 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 742799281 108 ELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNYL 149
Cdd:cd18265   86 GLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCL 127
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-147 3.57e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 94.78  E-value: 3.57e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGG 107
Cdd:cd18256    3 HASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTG 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 742799281 108 ELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147
Cdd:cd18256   83 VVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSN 122
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
324-527 5.23e-23

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 99.07  E-value: 5.23e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 324 QWVKETPLPARRSHHCVAVLGGFIFIAGGSfsrdnggdaasnllyrftygHAGTIYKDFvyisgghdyqigpyrknlLCY 403
Cdd:COG3055    2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGL--------------------SGGSASNSF------------------EVY 43

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 404 DHRTDVWEERRPMTTARGWHSMC-SLGDSIYSIGGSDDNIESMERFDvlGVEAYSPQCNQWTRVAPLLHANSESGVAVWE 482
Cdd:COG3055   44 DPATNTWSELAPLPGPPRHHAAAvAQDGKLYVFGGFTGANPSSTPLN--DVYVYDPATNTWTKLAPMPTPRGGATALLLD 121

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 742799281 483 GRIYILGGYSWENtaFSKTVQVYDREADKWSRGVDLPKAIAGGSA 527
Cdd:COG3055  122 GKIYVVGGWDDGG--NVAWVEVYDPATGTWTQLAPLPTPRDHLAA 164
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-149 7.17e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 93.96  E-value: 7.17e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  27 DHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYG 106
Cdd:cd18336    1 NHAEQTFRKMENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVHYAYT 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 742799281 107 GELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNYL 149
Cdd:cd18336   81 GVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCL 123
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-140 8.11e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 93.51  E-value: 8.11e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  33 LQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGELVLD 112
Cdd:cd18238    3 FKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLTLT 82

                         90       100
                 ....*....|....*....|....*...
gi 742799281 113 GGNIDYVLETAHLLQIWTVVDFCCEYLE 140
Cdd:cd18238   83 VDNVQSLLYAASLLQVEEVAKACCEFMK 110
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-149 2.73e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 92.54  E-value: 2.73e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  27 DHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYG 106
Cdd:cd18268    5 DLSSELLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVDYVYT 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 742799281 107 GELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNYL 149
Cdd:cd18268   85 GEILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCL 127
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-147 3.96e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 92.17  E-value: 3.96e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGG 107
Cdd:cd18264   11 HGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGLQRVLDFIYTS 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 742799281 108 ELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147
Cdd:cd18264   91 WLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPEN 130
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-149 5.82e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 91.82  E-value: 5.82e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGG 107
Cdd:cd18259   15 HPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMESLIDFAYTG 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 742799281 108 ELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNYL 149
Cdd:cd18259   95 KLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCL 136
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-143 1.09e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 90.52  E-value: 1.09e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGG 107
Cdd:cd18338    4 HMKKAFKVMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYTA 83

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 742799281 108 ELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEV 143
Cdd:cd18338   84 EIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQL 119
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-140 1.81e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 89.94  E-value: 1.81e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  27 DHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIG--MREAFQKEVELIGASyiGLKAVVDFL 104
Cdd:cd18328    7 NHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGtlADQPYVYEIDFVTPE--ALSAILEFA 84

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 742799281 105 YGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLE 140
Cdd:cd18328   85 YTSTLTITTSNVKHILNAAQMLEIQCIINVCLEIMD 120
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 148-248 3.83e-21

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 88.17  E-value: 3.83e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281   148 YLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQnVSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQQPE-REA 226
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLE-LPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEkRRE 79

                           90       100
                   ....*....|....*....|..
gi 742799281   227 HARQVLENIHFPLIPKNDLLHR 248
Cdd:smart00875  80 HLPELLEHVRLPLLSPDYLLEV 101
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-143 6.11e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 88.62  E-value: 6.11e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGG 107
Cdd:cd18339    4 HMKKAFKVMNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTA 83

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 742799281 108 ELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEV 143
Cdd:cd18339   84 EIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQL 119
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-147 7.99e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 88.29  E-value: 7.99e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGG 107
Cdd:cd18250    4 HALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYTG 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 742799281 108 ELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147
Cdd:cd18250   84 RVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSN 123
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-149 1.15e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 87.81  E-value: 1.15e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  27 DHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYG 106
Cdd:cd18337    5 NHAEQTFKKMENYLRHKQLCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPNALWALVQYAYT 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 742799281 107 GELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNYL 149
Cdd:cd18337   85 GRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCL 127
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-147 3.13e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 87.19  E-value: 3.13e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  26 ADHSSTVLQRLNEQRLRGLFCDVVLVAD--------EQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGL 97
Cdd:cd18273    7 AAHARALLAQLKSFYDARLLTDVTIEVNgpgsgpgsGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDSESM 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 742799281  98 KAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147
Cdd:cd18273   87 ALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSN 136
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-142 4.10e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 86.28  E-value: 4.10e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  27 DHSSTVLQRLNEQRLRGLFCDVVLVADEQRV----PAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVD 102
Cdd:cd18248    3 DHTKEAFQIMNELRLSQQLCDVTLKVKYQDPkeefMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRLIE 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 742799281 103 FLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQE 142
Cdd:cd18248   83 FAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQ 122
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-139 6.29e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 86.24  E-value: 6.29e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281   2 MEGSRQTRVSRPYKISESSKvyrwaDHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMRE 81
Cdd:cd18246    1 MEGGVQLLNRDGHSISHNSK-----RHYHDAFVSMNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSE 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 742799281  82 AFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYL 139
Cdd:cd18246   76 SRQTHVTLHDIDPQALEQLVQYAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFL 133
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-149 6.53e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 86.20  E-value: 6.53e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281   7 QTRVSRPYKISESSKVYRWADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKE 86
Cdd:cd18267    2 ENRKSRASSGSMNIYLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQDSE 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 742799281  87 VELIGASYIG-LKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNYL 149
Cdd:cd18267   82 VNFHDSIHPEvLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCL 145
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-149 1.07e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 85.06  E-value: 1.07e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  26 ADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIG-LKAVVDFL 104
Cdd:cd18254    3 PSHPDCVLTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHDSLHPEvLELLLDFA 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 742799281 105 YGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNYL 149
Cdd:cd18254   83 YSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCL 127
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-149 1.24e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 84.81  E-value: 1.24e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGG 107
Cdd:cd18249    6 HPRQTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLIDFAYTS 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 742799281 108 ELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNYL 149
Cdd:cd18249   86 QITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCL 127
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-150 1.43e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 84.48  E-value: 1.43e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTigmREAFQKEVELIGASYIGLKAVVDFLYGG 107
Cdd:cd18260    1 YGANLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILK---KDPSLQRVELNDISPLGLATVITYAYTG 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 742799281 108 ELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNYLY 150
Cdd:cd18260   78 KLTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCMY 120
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-147 6.78e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 83.08  E-value: 6.78e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  21 KVYRWADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAV 100
Cdd:cd18244    6 EVYNSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHV 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 742799281 101 VDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147
Cdd:cd18244   86 LQFMYYGTIELSMLTVHEILQAAMYVQLTEVVKFCCSFLLAKICLDN 132
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-147 8.55e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 82.74  E-value: 8.55e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  27 DHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYG 106
Cdd:cd18270    8 EYAVSLLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYT 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 742799281 107 GELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147
Cdd:cd18270   88 GNLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAEN 128
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-140 1.26e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 82.20  E-value: 1.26e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  27 DHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQK---------EVELIGASYIGl 97
Cdd:cd18327    7 EHSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGDLgagggqdvcELDFVGPEALG- 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 742799281  98 kAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLE 140
Cdd:cd18327   86 -ALLEFAYTATLTISSSNMREVLRAARLLEIPCVADACADILQ 127
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 143-238 1.37e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 80.93  E-value: 1.37e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 143 VSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQnVSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQQP 222
Cdd:cd18449    1 VSLENCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVK-LPFERLAFVLSSNSLKGCTELELFKAACRWLRHED 79

                         90
                 ....*....|....*.
gi 742799281 223 EREAHARQVLENIHFP 238
Cdd:cd18449   80 DRMQFAAKLMENIRFP 95
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-140 3.75e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 80.08  E-value: 3.75e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  33 LQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMF--TIGMREAFQKEVELIGASYIGLKAVVDFLYGGELV 110
Cdd:cd18245    2 LRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLnyNPPKDDGSTYKIELEGISVEVMEEILDYIYTGQIK 81

                         90       100       110
                 ....*....|....*....|....*....|
gi 742799281 111 LDGGNIDYVLETAHLLQIWTVVDFCCEYLE 140
Cdd:cd18245   82 LSEDNIQDIVQAADLLLMTDLKDLCCEFLE 111
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
296-449 9.07e-18

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 83.67  E-value: 9.07e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 296 RLLFVGGEVSERCLelsDDTCYLDAKSEQWVKETPLPARRSHHCVAVL-GGFIFIAGG-SFSRDNGGDAASNLLYRFTYG 373
Cdd:COG3055  123 KIYVVGGWDDGGNV---AWVEVYDPATGTWTQLAPLPTPRDHLAAAVLpDGKILVIGGrNGSGFSNTWTTLAPLPTARAG 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 374 HAGTIYKDFVYISGGHDYqigpYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDDN------IESMER 447
Cdd:COG3055  200 HAAAVLGGKILVFGGESG----FSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKPgvrtplVTSAEV 275


                 ..
gi 742799281 448 FD 449
Cdd:COG3055  276 YD 277
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-139 9.37e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 79.46  E-value: 9.37e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  26 ADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLY 105
Cdd:cd18276    2 QKHSLTLLDQLNRMKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMY 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 742799281 106 GGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYL 139
Cdd:cd18276   82 SSDLHLTNSNVQGVATAAFFLQMEDIFSVCQKYM 115
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-149 1.16e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 79.10  E-value: 1.16e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  26 ADHSSTVLQRLNEQRLRGLFCDVVLVADEQRV-PAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFL 104
Cdd:cd18252    2 SSHPADFLDAFRTFYLDGLFTDITLQCASGQIfHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYV 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 742799281 105 YGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNYL 149
Cdd:cd18252   82 YTSQICITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCL 126
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-141 1.35e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 79.24  E-value: 1.35e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  20 SKVYRWADHSSTVLQRLNEQRLRG-LFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQ-KEVELIGASYIGL 97
Cdd:cd18207    1 SYTYQVSQHSADMLHNLNQQRKSGgRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGTpRELEMHTISSKVF 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 742799281  98 KAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQ 141
Cdd:cd18207   81 GDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVIKQ 124
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-149 1.83e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 78.55  E-value: 1.83e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGG 107
Cdd:cd18335    2 HAEQTFRKMESYLKQQQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTG 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 742799281 108 ELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNYL 149
Cdd:cd18335   82 CLELKEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCL 123
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-149 1.95e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 78.46  E-value: 1.95e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGG 107
Cdd:cd18306    1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTS 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 742799281 108 ELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNYL 149
Cdd:cd18306   81 RLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCI 122
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-147 4.38e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 77.97  E-value: 4.38e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  26 ADHSSTVLQRLNEQRLRGLFCDVVLV---ADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIG------ 96
Cdd:cd18241    4 SSHCSELSWRQNEQRKQGLFCDITLAfggAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWSSEPgpdpdt 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 742799281  97 LKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147
Cdd:cd18241   84 VEAVIQYMYTGRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSN 134
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-147 5.09e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 77.72  E-value: 5.09e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRV-PAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYG 106
Cdd:cd18274    5 HACSILQQLKAMYDEGQLTDIVVEVDHGKTfSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDYAYT 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 742799281 107 GELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147
Cdd:cd18274   85 SRVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQN 125
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-135 8.15e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 76.51  E-value: 8.15e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIgmreafQKE-VELIGASYIGLKAVVDFLYG 106
Cdd:cd18206    5 HSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVD------QKDvVHLDISNAAGLGQVLEFMYT 78

                         90       100
                 ....*....|....*....|....*....
gi 742799281 107 GELVLDGGNIDYVLETAHLLQIWTVVDFC 135
Cdd:cd18206   79 AKLSLSPENVDDVLAVATFLQMQDIVTAC 107
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 39-144 1.05e-16

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 76.39  E-value: 1.05e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  39 QRLRGLF-----CDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGELVLDG 113
Cdd:cd18263    2 QSIEGLWekgvgCDVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHLSW 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 742799281 114 GNIDYVLETAHLLQIWTVVDFCCEYLEQEVS 144
Cdd:cd18263   82 ENLFEATCTALQLQISGALALCLDFLQREIS 112
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-140 1.08e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 76.08  E-value: 1.08e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMF---TIGMREAFQKEVELIGasyiGLKAVVDFL 104
Cdd:cd18233    1 HSCHLLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFqnsSSQKNDVFHLDIKNVG----GIGQILDFM 76

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 742799281 105 YGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLE 140
Cdd:cd18233   77 YTSHLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFLK 112
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-139 1.11e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 76.12  E-value: 1.11e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  27 DHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYG 106
Cdd:cd18287    4 DHVHFLSEDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIYT 83

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 742799281 107 GELVLDG---GNIDYVLETAHLLQIWTVVDFCCEYL 139
Cdd:cd18287   84 GRLTLTDlkeDVLLDVLGLAHQYGFEELEAAISDYL 119
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-135 1.24e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 76.07  E-value: 1.24e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFtigmREAFQKEVELI----GASYIGLKAVVDF 103
Cdd:cd18215    2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIF----TDQLKNNVSVInldpEIEPEGFRILLDF 77

                         90       100       110
                 ....*....|....*....|....*....|..
gi 742799281 104 LYGGELVLDGGNIDYVLETAHLLQIWTVVDFC 135
Cdd:cd18215   78 MYTSRLNLREGNIMAVMATAMYLQMEHVVDTC 109
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-114 2.23e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 75.70  E-value: 2.23e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFT-------------IGMREAFQKEVELIGASY 94
Cdd:cd18195    1 HAGALLLQLNEQRLRGLFCDVTLIAGDTKFRAHRSVLAASSPYFRELLSsplplgaaavaaaPGATQSPERVLELPGVKA 80

                         90       100
                 ....*....|....*....|
gi 742799281  95 IGLKAVVDFLYGGELVLDGG 114
Cdd:cd18195   81 GVFSDVLNFIYSSRVALPGS 100
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-139 4.10e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 74.72  E-value: 4.10e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  23 YRWADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSmftigmREAFQKEVELI-----GASYIGL 97
Cdd:cd18277    5 YESSVHSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHS------RIVGQADAELNitlpeEVTVKGF 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 742799281  98 KAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYL 139
Cdd:cd18277   79 EPLIQFAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-135 5.45e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 74.09  E-value: 5.45e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  26 ADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGA-SYIGLKAVVDFL 104
Cdd:cd18329    2 SSHQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATFDVfSPDTFTIILDFV 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 742799281 105 YGGELVLDGGNIDYVLETAHLLQIWTVVDFC 135
Cdd:cd18329   82 YSGKLSLTSQNVIEVMSAASYLQMTDVISVC 112
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-135 6.60e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 73.64  E-value: 6.60e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGAsyIGLkaVVDFLYGG 107
Cdd:cd18232    1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSGSVVLPESFAEV--FGL--LLDFFYTG 76

                         90       100
                 ....*....|....*....|....*...
gi 742799281 108 ELVLDGGNIDYVLETAHLLQIWTVVDFC 135
Cdd:cd18232   77 ELALTRENRDRVLLAAKELRVPEAVELC 104
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-148 1.03e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 73.92  E-value: 1.03e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIgmreafqKEVELIGASYIGLKAVVDFLYGG 107
Cdd:cd18243   15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSI-------NNLVLQGCSSIGLRLVLEYLYTA 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 742799281 108 ELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNY 148
Cdd:cd18243   88 NVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNY 128
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-139 5.75e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 71.30  E-value: 5.75e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGA-SYIGLKAVVDFLYG 106
Cdd:cd18199    1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTGRPSTASFDVfSSDAFSIILDFVYS 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 742799281 107 GELVLDGGNIDYVLETAHLLQIWTVVDFCCEYL 139
Cdd:cd18199   81 GKLSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-135 7.40e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 71.04  E-value: 7.40e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFT----IGMREAFqkeVELIGASYIGLKAVVDF 103
Cdd:cd18202    2 HGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIekgaVSSHEAV---VDLSGFCKSSFLPLLEF 78

                         90       100       110
                 ....*....|....*....|....*....|..
gi 742799281 104 LYGGELVLDGGNIDYVLETAHLLQIWTVVDFC 135
Cdd:cd18202   79 AYTSELTFDFCSMAEVAMLARHLFMNEVLEIC 110
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-140 7.86e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 71.14  E-value: 7.86e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  32 VLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKE--VELIGASYIGLKAVVDFLYGGEL 109
Cdd:cd18201    8 LLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKESCDQTtvTHLDVVAVQGFSVILDFMYSGNL 87

                         90       100       110
                 ....*....|....*....|....*....|.
gi 742799281 110 VLDGGNIDYVLETAHLLQIWTVVDFCCEYLE 140
Cdd:cd18201   88 VLTSQNAIEVMSVASYLQMTEVVQSCRNFIK 118
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-133 8.62e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 71.21  E-value: 8.62e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  30 STVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYiglKAVVDFLYGGEL 109
Cdd:cd18289   14 NTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPATVPPACF---QQILSFCYTGKL 90

                         90       100
                 ....*....|....*....|....
gi 742799281 110 VLDGGNIDYVLETAHLLQIWTVVD 133
Cdd:cd18289   91 TMAASEQLVVMYTAGFLQIQHIVE 114
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-140 9.05e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 70.86  E-value: 9.05e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMF---TIGMREAFQKEVELIGASyiGLKAVVDFL 104
Cdd:cd18230    4 HYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYcqvQKTSDQATVTHLDIVTAQ--GFKAIIDFM 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 742799281 105 YGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLE 140
Cdd:cd18230   82 YSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIK 117
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-137 1.04e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 70.59  E-value: 1.04e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  31 TVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEV-ELIGASYIGLKAVVDFLYGGEL 109
Cdd:cd18293    1 TAFLQLHRQQNSGVFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPPPAGQKVVlELQGLKAHTLLKLVDFLYTSEL 80

                         90       100
                 ....*....|....*....|....*...
gi 742799281 110 VLDGGNIDYVLETAHLLQIWTVVDFCCE 137
Cdd:cd18293   81 EVSSEEAQDVLAAARRLQISELESLCLE 108
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-147 1.33e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 70.65  E-value: 1.33e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  30 STVLQR-LNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGE 108
Cdd:cd18236    8 SLVLQNgLENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILLDYTYTSK 87

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 742799281 109 LVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147
Cdd:cd18236   88 VLITKQNVQRVLEAASLFQFLRMVDACASFLTEALHPEN 126
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-128 1.36e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 69.90  E-value: 1.36e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAfQKEVELIGASYIGLKAVVDFLYGG 107
Cdd:cd18209    1 HAISLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTEKENES-QSVFQLDFCEPDAFENVLNYIYSS 79

                         90       100
                 ....*....|....*....|.
gi 742799281 108 ELVLDGGNIDYVLETAHLLQI 128
Cdd:cd18209   80 SLFVEKSSLAAVQELGYSLGI 100
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-138 1.38e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 70.45  E-value: 1.38e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  30 STVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYiglKAVVDFLYGGEL 109
Cdd:cd18290   12 NSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAVQPQSF---QQILSFCYTGRL 88

                         90       100
                 ....*....|....*....|....*....
gi 742799281 110 VLDGGNIDYVLETAHLLQIWTVVDFCCEY 138
Cdd:cd18290   89 SMNVGDQFLLMYTAGFLQIQEIMEKGTEF 117
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-141 2.08e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 69.50  E-value: 2.08e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  29 SSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAfqkEVELIGASYIgLKAVVDFLYGGE 108
Cdd:cd18229    2 SKSLLETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFFHDKLLLGHSEI---EVPPVVPAQT-VRQLVEFMYSGS 77

                         90       100       110
                 ....*....|....*....|....*....|...
gi 742799281 109 LVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQ 141
Cdd:cd18229   78 LVVAQSEALQILTAASILQIKTVIDECTQIISQ 110
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-146 2.10e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 70.45  E-value: 2.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  27 DHSSTVLQRLNEQRLRGLFCD-VVLVADEQrVPAHRNLLAVCSDYFNSMF--TIGMREAFQKEVELIGASYIGLkaVVDF 103
Cdd:cd18324    5 DHSRHLLQCLSEQRHQGFLCDcTVLVGDAQ-FRAHRAVLASCSMYFHLFYkdQLDKRDIVHLNSDIVTAPAFAL--LLEF 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 742799281 104 LYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSED 146
Cdd:cd18324   82 MYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEKATTE 124
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-135 2.16e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 69.40  E-value: 2.16e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFtigmREAFQKEVEL--IGASYIGLKAVVDFLY 105
Cdd:cd18217    1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQY----KDTEDNIVFLdqSQVSADGFQKLLEFIY 76

                         90       100       110
                 ....*....|....*....|....*....|
gi 742799281 106 GGELVLDGGNIDYVLETAHLLQIWTVVDFC 135
Cdd:cd18217   77 TGNLNLDSWNVAEIHQAASYLGMEEVVAKC 106
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-151 2.74e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 69.86  E-value: 2.74e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  27 DHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYG 106
Cdd:cd18271    6 CHGQQILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDYAYT 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 742799281 107 GELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNYLYL 151
Cdd:cd18271   86 GKAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCLQL 130
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-135 3.35e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 69.46  E-value: 3.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  27 DHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFT--IGMREAFQKEVELIGASYIGLkaVVDFL 104
Cdd:cd18194    5 EHSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRdrLDKRDLVRLNSDIVTAPAFGL--LLDFM 82

                         90       100       110
                 ....*....|....*....|....*....|.
gi 742799281 105 YGGELVLDGGNIDYVLETAHLLQIWTVVDFC 135
Cdd:cd18194   83 YEGRLALRDLPVEDVLAAASYLHMYDIVKVC 113
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-75 5.10e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 68.28  E-value: 5.10e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMF 75
Cdd:cd18223    1 HSDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAF 48
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-149 5.58e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 68.97  E-value: 5.58e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  16 ISESSKVYRwadhsSTVLQR-LNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASY 94
Cdd:cd18269    2 QKEELRLYQ-----QTLLQDgLKDLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDP 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 742799281  95 IGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNYL 149
Cdd:cd18269   77 DVMGMILKYLYTSEIDLNDQNVQDIFALASRFQIPSIFTVCVSYLQKRLSLSNCL 131
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-139 8.72e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 68.15  E-value: 8.72e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTI----GMREAFQKEVELIGASyiGLKAVVDF 103
Cdd:cd18196    4 HFEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFTVaegdQTMNMIQLDSEVVTAE--AFAALIDM 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 742799281 104 LYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYL 139
Cdd:cd18196   82 MYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYL 117
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-149 1.17e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 67.95  E-value: 1.17e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  16 ISESSKVYRwadhsSTVLQR-----LNEQRlrglFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELI 90
Cdd:cd18341    2 IKEELRLYQ-----STLLQDglkelLDENK----FVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLD 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 742799281  91 GASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNYL 149
Cdd:cd18341   73 NVDPNIMDMILKYLYSAEIDLNDGNVQDIFALASRFQIPSVFTVCVTYLQKRLSPANCL 131
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 45-128 1.37e-13

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 66.42  E-value: 1.37e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  45 FCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTigmREAFQKEVELI--GASYIGLKAVVDFLYGGELVLDGGNIDYVLET 122
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLK---ETPPDEHPVIIlpDVPYSELKALLDFIYTGEVNVSQEQLESLLKL 77


                 ....*.
gi 742799281 123 AHLLQI 128
Cdd:cd18315   78 AELLQI 83
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 42-143 1.42e-13

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 66.88  E-value: 1.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  42 RGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGELVlDGGNIDYV-- 119
Cdd:cd18300    6 KGLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAP-ILEDGDCVgl 84

                         90       100
                 ....*....|....*....|....
gi 742799281 120 LETAHLLQIWTVVDFCCEYLEQEV 143
Cdd:cd18300   85 IVLANRLCLPRLVALCEQYIVKEL 108
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-149 2.06e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 66.92  E-value: 2.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  32 VLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIG---LKAVVDFLYGGE 108
Cdd:cd18258    4 MLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGEKLELTMSNINadvLELLLEFVYTGS 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 742799281 109 LVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNYL 149
Cdd:cd18258   84 LIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCL 124
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 48-126 3.36e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 65.00  E-value: 3.36e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 742799281  48 VVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLL 126
Cdd:cd01165    1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-140 3.91e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 66.12  E-value: 3.91e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  27 DHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSmftigmreafqkEVELIGASYIGLKAVVD---- 102
Cdd:cd18227    7 DFSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCD------------QVLLKNSRRIVLPDVMNprvf 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 742799281 103 -----FLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLE 140
Cdd:cd18227   75 enillSCYTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELLE 117
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-143 4.09e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 66.42  E-value: 4.09e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKE-------VELIGASYIGLKAV 100
Cdd:cd18228    2 HSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLVLVspagkcvLDLHHVTVTGFAPL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 742799281 101 VDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEV 143
Cdd:cd18228   82 LEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSI 124
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-139 4.18e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 65.72  E-value: 4.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  30 STVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQ---KEVELIGASYIGLkaVVDFLYG 106
Cdd:cd18330    3 TKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRhstASLDIVTSEAFSI--ILDFLYS 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 742799281 107 GELVLDGGNIDYVLETAHLLQIWTVVDFCCEYL 139
Cdd:cd18330   81 GKLDLCSENVIEVMSAASYLQMTDVVNFCKGYI 113
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-140 4.46e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 65.65  E-value: 4.46e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGG 107
Cdd:cd18332    2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTLPSGLEARGFQLLLDFMYTS 81

                         90       100       110
                 ....*....|....*....|....*....|...
gi 742799281 108 ELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLE 140
Cdd:cd18332   82 RLPLTPRTVPAVLAAATYLQMEHVVETCRRFIQ 114
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-139 4.86e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 65.71  E-value: 4.86e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  33 LQRLNEQRL-RGLFCDVVLVADEQR--VPAHRNLLAVCSDYFNSMFTigMREAFQK-EVELIGASYIGLKAVVDFLYGGE 108
Cdd:cd18231    1 MDRLNEQRLfQPDLCDVDIVLVRQRstFPAHKGVLAAYSQFFHSLFT--QNKQLQRvELSLEALTSQGLQQILNFIYTSK 78

                         90       100       110
                 ....*....|....*....|....*....|.
gi 742799281 109 LVLDGGNIDYVLETAHLLQIWTVVDFCCEYL 139
Cdd:cd18231   79 LLVNSCNVQDVLNAAAVLQMNDIAASCQELI 109
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-149 5.58e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 66.01  E-value: 5.58e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  43 GLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLET 122
Cdd:cd18340   25 NKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYTSEIEITEQNVQDIFAA 104

                         90       100
                 ....*....|....*....|....*..
gi 742799281 123 AHLLQIWTVVDFCCEYLEQEVSEDNYL 149
Cdd:cd18340  105 ANMFQIPSIFTVCVSFLQKRLCLSNCL 131
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-132 6.13e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 65.59  E-value: 6.13e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMrEAFQKEVELIGASYIGLKAVVDFLYGG 107
Cdd:cd18212    6 HKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADEG-EVGQSIYMLEGMVAETFGALLEFIYTG 84

                         90       100
                 ....*....|....*....|....*
gi 742799281 108 ELVLDGGNIDYVLETAHLLQIWTVV 132
Cdd:cd18212   85 CLQVGEKSLEQILATAQFLKVNDLV 109
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-135 6.30e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 65.83  E-value: 6.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  27 DHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMF--TIGMREAFQKEVELIGASYIGLkaVVDFL 104
Cdd:cd18325    5 DHSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFHLFYrdQLDKRDIVHLNSDIVTAPAFSL--LLEFM 82

                         90       100       110
                 ....*....|....*....|....*....|.
gi 742799281 105 YGGELVLDGGNIDYVLETAHLLQIWTVVDFC 135
Cdd:cd18325   83 YEGKLEFSSLPVEDVLAAASYLHMYDIVKVC 113
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-135 1.79e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 64.46  E-value: 1.79e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  27 DHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNsMF---TIGMREAFQKEVELIGASYIGLkaVVDF 103
Cdd:cd18323    5 DHSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFH-MFykeQLDKRDLVCINNEIVTAPAFSL--LLEF 81

                         90       100       110
                 ....*....|....*....|....*....|..
gi 742799281 104 LYGGELVLDGGNIDYVLETAHLLQIWTVVDFC 135
Cdd:cd18323   82 MYEGRLSFNDTPVEDVLAAASYLHMNDIVKVC 113
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 143-240 2.07e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 63.39  E-value: 2.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 143 VSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQnVSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQQP 222
Cdd:cd18465    1 MSVETCLNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLH-LPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHDP 79

                         90
                 ....*....|....*...
gi 742799281 223 EREAHARQVLENIHFPLI 240
Cdd:cd18465   80 SRRASASHVLCHIRFPLM 97
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-135 5.13e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 63.29  E-value: 5.13e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  27 DHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMF---TIGMREAFQKEVELIGASYIGLkaVVDF 103
Cdd:cd18956    5 EHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYrdrPAGGRDTVRLNGDIVTAPAFGR--LLDF 82

                         90       100       110
                 ....*....|....*....|....*....|..
gi 742799281 104 LYGGELVLDGGNIDYVLETAHLLQIWTVVDFC 135
Cdd:cd18956   83 MYEGRLDLRSLPVEDVLAAASYLHMYDIVKVC 114
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-141 5.57e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 62.77  E-value: 5.57e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  27 DHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVeligASYIGLKAVVDFLYG 106
Cdd:cd18208    7 NFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSV----VSVQSVQKLIDFMYS 82

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 742799281 107 GELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQ 141
Cdd:cd18208   83 GVLRVSQSEALQILTAASILQIKTVIDECTRIVSQ 117
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-139 6.27e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 62.66  E-value: 6.27e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  22 VYRWADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFtigmreAFQKEVELI-----GASYIG 96
Cdd:cd18278    8 VYESTVHCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQAL------VGQTENDLVvslpeEVTARG 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 742799281  97 LKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYL 139
Cdd:cd18278   82 FGPLLQFAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-139 7.48e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 62.57  E-value: 7.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGG 107
Cdd:cd18331    7 HASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFNILLDFMYTS 86

                         90       100       110
                 ....*....|....*....|....*....|..
gi 742799281 108 ELVLDGGNIDYVLETAHLLQIWTVVDFCCEYL 139
Cdd:cd18331   87 RLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 118
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-113 1.56e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 61.17  E-value: 1.56e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFtigmrEAFQKE--VELIGASYIGLKAVVDFLY 105
Cdd:cd18221    1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFF-----QDFTQEplVEIEGVSNMAFRHLIEFTY 75


                 ....*...
gi 742799281 106 GGELVLDG 113
Cdd:cd18221   76 TAKLMVQG 83
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-139 1.57e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 61.40  E-value: 1.57e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  29 SSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSmftigmreafqkEVELIGASYIGLKAVVDFL---- 104
Cdd:cd18210    5 TSSLLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFHD------------QVLLKNMSSISLPGVMDPGafes 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 742799281 105 -----YGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYL 139
Cdd:cd18210   73 vlasaYTGKLTMLADEIVNYLTVGSVLQMWHIVDKCTELL 112
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 147-274 1.77e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 61.59  E-value: 1.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 147 NYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLqNVSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQQPE-RE 225
Cdd:cd18512    5 NCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFL-NLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKEvRQ 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 742799281 226 AHARQVLENIHFPLIPKNDLLHRVKPAvcSLLPKEANCEGFIEEAVRYH 274
Cdd:cd18512   84 EHMAHLMEHVRLPLLSREYLVQRVEEE--TLVKNSSACKDYLIEAMKYH 130
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-77 1.95e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 61.00  E-value: 1.95e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 742799281  26 ADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTI 77
Cdd:cd18219    2 TQYSGSLLKSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLFSV 53
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-135 3.10e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 60.62  E-value: 3.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  26 ADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMF-TIGMREAFQKEVELIGASyiGLKAVVDFL 104
Cdd:cd18224    7 SDHPNNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLFlSTELDVARTYVVDFITPA--NFEKVLSFI 84

                         90       100       110
                 ....*....|....*....|....*....|.
gi 742799281 105 YGGELVLDGGNIDYVLETAHLLQIWTVVDFC 135
Cdd:cd18224   85 YTSELFTDLINVGVIYEVAEKLGMEDLLKAC 115
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-137 3.43e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 60.44  E-value: 3.43e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFtigmreafqKEVELIGASYIGL--------KA 99
Cdd:cd18204    1 HKTVFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLF---------KKLEVDSSSVIEIdflrsdifEE 71

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 742799281 100 VVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCE 137
Cdd:cd18204   72 VLNYMYTAKISVKKEDVNLMMSSGQILGIRFLDKLCSQ 109
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-141 7.77e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 59.60  E-value: 7.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  27 DHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMftIGMREAFQKEVELIGASYigLKAVVDFLYG 106
Cdd:cd18334    3 NHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSL--VLHDNLINLDTDMVNPTV--FRQILDFIYT 78

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 742799281 107 GELVLDGG----NIDYVLETAHLLQIWTVVDFCCEYLEQ 141
Cdd:cd18334   79 GKLLTSDQpgeqNFNALLTAASYLQLHDLAALCRKKLKR 117
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-140 8.65e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 59.67  E-value: 8.65e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  27 DHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGmreafqkEVELIGASYIG----LKAVVD 102
Cdd:cd18222    7 DFSNSVLSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMSLN-------EMSTVSISVIKnptvFEQLLS 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 742799281 103 FLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLE 140
Cdd:cd18222   80 FCYTGRICLQLADIISYLTAASFLQMQHIIDKCTQILE 117
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-141 1.32e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 58.71  E-value: 1.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLkavVDFLYGG 107
Cdd:cd18200    1 YSSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHDKLLLNDTNCLVLPSVIEAAAFENL---LQLIYSG 77

                         90       100       110
                 ....*....|....*....|....*....|....
gi 742799281 108 ELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQ 141
Cdd:cd18200   78 RLTLCMDALPSHLLVASGLQMWQVVDRCSELLKE 111
BACK_KLHL22 cd18461
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...
 143-240 3.00e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.


Pssm-ID: 350536  Cd Length: 104  Bit Score: 57.46  E-value: 3.00e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 143 VSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQnVSMQKLCVYLSSSEVQRECEHDLLQAALqwLTQQP 222
Cdd:cd18461    1 VDEENILDVYKLADLFHLTHLSEQLDSYILKNFPTFSRTETYRQ-LPLEKVYSLLSSNRLEVDSENEVYEGAL--LYHYT 77

                         90       100
                 ....*....|....*....|....*.
gi 742799281 223 EREAHARQV--------LENIHFPLI 240
Cdd:cd18461   78 PEQVEKDQVslqeppklLEAVRFPLM 103
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-140 3.73e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 57.73  E-value: 3.73e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  27 DHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQkeVELIGASYIgLKAVVDFLYG 106
Cdd:cd18220    7 EYSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLS--ISVIKNPNV-FEQLLSFCYT 83

                         90       100       110
                 ....*....|....*....|....*....|....
gi 742799281 107 GELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLE 140
Cdd:cd18220   84 GRMSLQLKDVVSFLTAASFLQMQCVIDKCTQILE 117
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 147-274 4.24e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 57.77  E-value: 4.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 147 NYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLqNVSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQQPE-RE 225
Cdd:cd18513    5 NCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFL-SLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKEaRL 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 742799281 226 AHARQVLENIHFPLIPKNDLLHRVKPAvcSLLPKEANCEGFIEEAVRYH 274
Cdd:cd18513   84 EHMAKLMEHVRLPLLPRDYLVQTVEEE--ALIKNNNTCKDFLIEAMKYH 130
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-141 7.60e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 56.77  E-value: 7.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFtigmreAFQKEVEL--IGASYIGLKAVVDFLY 105
Cdd:cd18216    3 HATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLV------LHDNLIHLdqDMVSPTVFQQILDFIY 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 742799281 106 GGELvLDGG----NIDYVLETAHLLQIWTVVDFCCEYLEQ 141
Cdd:cd18216   77 TGKL-LDSLfeepNLSEVLAAANYLQLPDLAALCRSKLKR 115
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 41-115 9.87e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 56.50  E-value: 9.87e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 742799281  41 LRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGN 115
Cdd:cd18286   13 LNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGVLDLPDDV 87
BACK_KLHL34 cd18473
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs ...
 143-245 1.22e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs to the KLHL family. Its function remains unclear. The methylation status of KLHL34 cg14232291 may be a predictive candidate of sensitivity to preoperative chemoradiation therapy.


Pssm-ID: 350548  Cd Length: 106  Bit Score: 55.90  E-value: 1.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 143 VSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLsFTPDF----LQNVSMQKLCVYLSSSEVQRECEHDLLQAALQWL 218
Cdd:cd18473    1 LSPENCCFSANIAARFGLPDALKAAEKYIISNLWRL-LASDAddagLLELNLESLQAVLEADDIPRVKESRLLTLVLEWL 79

                         90       100
                 ....*....|....*....|....*..
gi 742799281 219 TQQPEREAHARQVLENIHFPLIPKNDL 245
Cdd:cd18473   80 NQDESRLAYANALLSRIRYGLVPVEEL 106
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-141 1.24e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 56.06  E-value: 1.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMftIGMREAFQKEVELIGASYigLKAVVDFLYGG 107
Cdd:cd18333    4 HSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSL--VVHDNLINLDHEMVSPGI--FRLILDYIYTG 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 742799281 108 ELV-LDGG---NIDYVLETAHLLQIWTVVDFCCEYLEQ 141
Cdd:cd18333   80 RLSeGDPGseqNLGAVLAAASYLQIPDLVALCKKKLKR 117
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-149 1.43e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 56.44  E-value: 1.43e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLR-GLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYG 106
Cdd:cd18272   14 HSSRVAQSIMDLCLEdGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIYH 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 742799281 107 GELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNYL 149
Cdd:cd18272   94 GTVKLRVEELQETYEVADMYQLTALFEECSRFLARTVQVRNCL 136
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-137 2.20e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 55.21  E-value: 2.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGG 107
Cdd:cd18192    4 HSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMMFINHQHTTAQLNLSNMKISAECFDLILQFMYLG 83

                         90       100       110
                 ....*....|....*....|....*....|
gi 742799281 108 ELVLDGGNIDYVLETAHLLQIWTVVDfCCE 137
Cdd:cd18192   84 KIMTAPSDFEQLKVAMNYLQLYYIPE-CLE 112
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-139 3.01e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 54.40  E-value: 3.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  46 CDVVLVADEQRVPAHRNLLAVCSDYFNSmftigmREAFQKEVELI-----GASYIGLKAVVDFLYGGELVLDGGNIDYVL 120
Cdd:cd18955    2 CDVTIVVEDQRFRAHRAVLAACSDYFLS------RVVGQTDGDLVitlpeEVTVKGFEPLLQFAYTAKLLLSKENVLEVC 75

                         90
                 ....*....|....*....
gi 742799281 121 ETAHLLQIWTVVDFCCEYL 139
Cdd:cd18955   76 RCAEFLGVHNIEKACFDFL 94
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
462-529 3.86e-09

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 57.86  E-value: 3.86e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 742799281 462 QWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTafSKTVQVYDREADKWSRGVDLPKAIAGGSACV 529
Cdd:COG3055    2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSA--SNSFEVYDPATNTWSELAPLPGPPRHHAAAV 67
BACK_KLHL15 cd18454
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a ...
 167-248 5.17e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for Cullin3 E3 ubiquitin-protein ligase complex that target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation.


Pssm-ID: 350529  Cd Length: 108  Bit Score: 54.13  E-value: 5.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 167 IDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQQPEREAHARQVLENIHFPLIPKNDLL 246
Cdd:cd18454   27 LDSFLLENFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQAWLRHDRRRWRHTDTIIQNIRFCLMTPTNVF 106


                 ..
gi 742799281 247 HR 248
Cdd:cd18454  107 EK 108
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-147 6.38e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 54.36  E-value: 6.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  25 WADHSSTVLQRLNEQRLRGLFCDVVLV----ADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQkEVELIGASYIGLKAV 100
Cdd:cd18281    2 WQASKTTVKERFAFLFNNETLSDVHFIvgkgDNEQRIPAHKFVLSIGSAVFDAMFNGGMATTSA-EIELPDVEPAAFLAL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 742799281 101 VDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147
Cdd:cd18281   81 LRFLYSDEVQIGPETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-138 1.14e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 52.50  E-value: 1.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  45 FCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIG---LKAVVDFLYGGELVLDGGNIDYVLE 121
Cdd:cd18307    1 FCDVVISVDNHSFAAHRNVLAAVSPFVKSLISSNDMKATDELSITIDCDYLSpetVEQLLDYFYTGKIVISEKNVEDLLK 80

                         90
                 ....*....|....*..
gi 742799281 122 TAHLLQIWTVVDFCCEY 138
Cdd:cd18307   81 GAKYFNIPRLKDHCVDF 97
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-147 1.30e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 53.54  E-value: 1.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  25 WADHSSTVLQRLNEQRLRGLFCDVVLVADE----QRVPAHRNLLAVCSDYFNSMFTIGMREAfQKEVELIGASYIGLKAV 100
Cdd:cd18347    2 WQATKPTVQERFAFLFNNEVLSDVHFLVGKglgsQRIPAHRFVLAVGSAVFDAMFNGGMATT-STEIELPDVEPAAFLAL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 742799281 101 VDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147
Cdd:cd18347   81 LKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 127
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 33-128 2.38e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 52.20  E-value: 2.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  33 LQRLNEQRLRGLFCDVVL-VADEQRVPAHRNLLAVCSDYFNSMF--------TIGMREAFQKEVeligasyigLKAVVDF 103
Cdd:cd18311    2 LQRLQNLFNKTEYCDLTLqFRDNEQLKVHRLVLSACTDYFNVLEqtceivddTLIMPNELQADA---------VVPVINF 72

                         90       100
                 ....*....|....*....|....*
gi 742799281 104 LYGGELVLDGGNIDYVLETAHLLQI 128
Cdd:cd18311   73 MYTGQLEFEEKSYGKLLRTAKELNM 97
PHA02713 PHA02713
hypothetical protein; Provisional
 44-490 4.14e-08

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 55.79  E-value: 4.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  44 LFCDVVL-VADEQRVPAHRNLLAVCSDYFNSMFTIGM--REAFQKeVELIGASYIGLKAVVDFLYGGElvLDGGNIDYVL 120
Cdd:PHA02713  24 ILCDVIItIGDGEEIKAHKTILAAGSKYFRTLFTTPMiiRDLVTR-VNLQMFDKDAVKNIVQYLYNRH--ISSMNVIDVL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 121 ETAHLLQIWTVVDFCCEYLEQEVSEDNYLY----LQELASIYSLKrldaFIDGFILNHFGTLsFTPDFLQNVSMQKLCVY 196
Cdd:PHA02713 101 KCADYLLIDDLVTDCESYIKDYTNHDTCIYmyhrLYEMSHIPIVK----YIKRMLMSNIPTL-ITTDAFKKTVFEILFDI 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 197 LSSSE---VQRECEHdlLQAALQWLTQQPEREAHARQVLENIHFPLIPKNDLLHRVKPAVCSLLPkeaNCEGFIEEAVRY 273
Cdd:PHA02713 176 ISTNDnvyLYREGYK--VTILLKWLEYNYITEEQLLCILSCIDIQNLDKKSRLLLYSNKTINMYP---SCIQFLLDNKQN 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 274 HNNLAAQPVMQTKRTALrtnqerllfvggEVSERCLELsddtcyLDAKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGs 353
Cdd:PHA02713 251 RNIIPRQLCLVCHDTKY------------NVCNPCILV------YNINTMEYSVISTIPNHIINYASAIVDNEIIIAGG- 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 354 fsrdnggdaasnllYRFTYGHAGTIYKdfvyisgghdyqigpyrknlLCYDHRTDVweERRPMTTARGWHSMCSLGDSIY 433
Cdd:PHA02713 312 --------------YNFNNPSLNKVYK--------------------INIENKIHV--ELPPMIKNRCRFSLAVIDDTIY 355

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 742799281 434 SIGGSDDNIesMERfdvlGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGG 490
Cdd:PHA02713 356 AIGGQNGTN--VER----TIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGG 406
Kelch smart00612
Kelch domain;
484-530 5.71e-08

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 49.09  E-value: 5.71e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 742799281   484 RIYILGGYSweNTAFSKTVQVYDREADKWSRGVDLPKAIAGGSACVC 530
Cdd:smart00612   1 KIYVVGGFD--GGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45
BTB_POZ_ZBTB12 cd18203
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-141 1.90e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349512 [Multi-domain]  Cd Length: 122  Bit Score: 49.88  E-value: 1.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  23 YRWADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQkeVELIGASyiglKAVVD 102
Cdd:cd18203    3 FQLPGHEAATLRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFLLNPSSELQ--VSLMHSS----RVVAD 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 742799281 103 FL---YGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQ 141
Cdd:cd18203   77 LLlscYTGALEFSVRDIVNYLTAASYLQMEHVVEKCRGALSQ 118
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 41-135 2.26e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 49.13  E-value: 2.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  41 LRGLFC-----DVVLVADE-QRVPAHRNLLAVCS----DYFNSMFTIGMREAFQKEVeligasyigLKAVVDFLYGGELV 110
Cdd:cd18299    3 LRNLLHspscaDVVFILQGgVRIFAHRIVLAAASsvfaDLFLMMTVVTLDSDITPEA---------FRRVLEFLYTGVLD 73

                         90       100
                 ....*....|....*....|....*
gi 742799281 111 LDGGNIDYVLETAHLLQIWTVVDFC 135
Cdd:cd18299   74 ENEDDLKELKDAAELLELFDLVMMC 98
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 45-135 2.70e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 48.88  E-value: 2.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  45 FCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAH 124
Cdd:cd18314    6 FSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLAS 85

                         90
                 ....*....|.
gi 742799281 125 LLQIWTVVDFC 135
Cdd:cd18314   86 KYQVPDLEKLC 96
BTB_POZ_KLHL42 cd18319
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 48-127 3.40e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349628 [Multi-domain]  Cd Length: 93  Bit Score: 48.33  E-value: 3.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  48 VVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQ 127
Cdd:cd18319    4 VQIRLEDRCYNVSKRKLIEQSDYFRALYRSGMRESGEEVVQLRGLSAPGLELVLDFINTSKVHESQGDSTDTLEENELLE 83
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 144-199 4.20e-07

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 46.89  E-value: 4.20e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 742799281 144 SEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQnVSMQKLCVYLSS 199
Cdd:cd14733    1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLE-LSVELLLELLSS 55
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 54-147 4.64e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 49.29  E-value: 4.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  54 EQRVPAHRNLLAVCSDYFNSMFTIGMREAfQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVD 133
Cdd:cd18346   41 AQRIPAHRFVLAAGSAVFDAMFNGGMATT-SAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEA 119

                         90
                 ....*....|....
gi 742799281 134 FCCEYLEQEVSEDN 147
Cdd:cd18346  120 HCVEFLTKHLRADN 133
BTB_POZ_ZBTB26_Bioref cd18214
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-139 7.66e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349523 [Multi-domain]  Cd Length: 122  Bit Score: 48.28  E-value: 7.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  23 YRWADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTigMREAFQKEVELIGASYIGLKAVVD 102
Cdd:cd18214    3 FRFENYGDSMLQKMNKLREQNKFCDVTVHIDDLEVPGHKVVFAAGSPFLRDQFL--LNDSREVQISILQNSEVGRQLLLS 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 742799281 103 fLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYL 139
Cdd:cd18214   81 -CYTGVLEFPEMELVNYLTAASFLQMSHIVERCTQAL 116
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 29-147 8.28e-07

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 48.15  E-value: 8.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  29 SSTVLQRLNEQRLRGL---FCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVElIGASYIGLKA---VVD 102
Cdd:cd18309    1 IGTTLEQDMEAFLESVggdFCDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPEDNTVNIS-IGEMVPSRQAfdsLLR 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 742799281 103 FLYGGELVLDGGNIDYVLE-------TAHLLQIwtvvdFCCEYLEQEVSEDN 147
Cdd:cd18309   80 YIYYGDVTMPPEDSLYLFSapyfygfTNNRLQA-----YCKQNLEMNVSFEN 126
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-142 1.08e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 47.34  E-value: 1.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFtigMREAFQKEVELIGASyiGLKAVVDFLYGG 107
Cdd:cd18205    1 HPTGLLHKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILF---HRNSQHYTLDFLSPK--TFQQILEYAYTA 75

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 742799281 108 ELVLDGGNIDYVLETAHLLQIwtvvdfccEYLEQE 142
Cdd:cd18205   76 TLQAKVEDLDDLLYAAEILEI--------EYLEEQ 102
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 45-135 1.19e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 47.36  E-value: 1.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  45 FCDVVLVA-DEQRVPAHRNLLAVCSDYFNSMFTIGMRE-AFQKEVELIGASYIgLKAVVDFLYGGEL--VLDGGNIDY-- 118
Cdd:cd18302    5 LYDVTIVSeDGKEFPCHKCVLVARLEYFHSMLSSSWIEaSSCSALTMPIPSDI-LEIILDYLYTDEAsaVKESQNVEFlc 83

                         90
                 ....*....|....*...
gi 742799281 119 -VLETAHLLQIWTVVDFC 135
Cdd:cd18302   84 nVLVIADQLLITRLKEIC 101
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-128 1.45e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 47.10  E-value: 1.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLR-GLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTigmREAFQKEVELIGASYIGLKAVVDFLYG 106
Cdd:cd18226    4 YNKNLLKYLNDDRQKqSSFCDLVITVEGKEFSAHKVVVAVGSSYFHACLS---KNPNTDAVTLDHVSYSVFQHLLEFLYT 80

                         90       100
                 ....*....|....*....|..
gi 742799281 107 GELVLDGGNIDYVLETAHLLQI 128
Cdd:cd18226   81 SEFFVYENEIPLVLEAAKFLDI 102
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-89 1.74e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 46.90  E-value: 1.74e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 742799281  29 SSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFT-IGMREAFQKEVEL 89
Cdd:cd18292    1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSnDWWSESKQSEIEL 62
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 143-218 2.11e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 45.46  E-value: 2.11e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 742799281 143 VSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLqNVSMQKLCVYLSSSEVQRECEHDLLQAALQWL 218
Cdd:cd18472    1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFL-SLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 47-147 2.86e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 46.50  E-value: 2.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  47 DVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGG---ELVLDGGNIDYVLETA 123
Cdd:cd18297   14 DVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGgveSLDVAQDDALELLRAA 93

                         90       100
                 ....*....|....*....|....
gi 742799281 124 HLLQIWTVVDFCCEYLEQEVSEDN 147
Cdd:cd18297   94 SFFQLDGLKRHCEILLSQQIDLDN 117
Kelch smart00612
Kelch domain;
383-430 3.76e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 44.09  E-value: 3.76e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 742799281   383 VYISGGHDYQIgpYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGD 430
Cdd:smart00612   2 IYVVGGFDGGQ--RLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-123 4.08e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 45.70  E-value: 4.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  44 LFCDVV-LVADEQR-VPAHRNLLAVCSDYFNSMFTIG-MREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVL 120
Cdd:cd18294   13 EFSDVKfLVGPERQeIFAHKCILAARCEVFRAMFLTGpQKESTQSPLVLSDIEPEVFRAVLEFIYTNCVTLSNHTVIEVL 92


                 ...
gi 742799281 121 ETA 123
Cdd:cd18294   93 AAA 95
BTB2_POZ_RHOBTB2 cd18359
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 35-109 4.18e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2); RhoBTB2, also called Deleted in breast cancer 2 gene protein (DBC2) or p83, is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB2 functions as a tumor suppressor that regulates the expression of the methyltransferase METTL7A. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349668 [Multi-domain]  Cd Length: 124  Bit Score: 46.15  E-value: 4.18e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 742799281  35 RLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGEL 109
Cdd:cd18359   10 RVKECLAKGTFSDVTFMLDDGTISAHKPLLISSCDWMAAMFGGPFVESSTTEVVFPYTSRSSMRAVLEYLYTGQF 84
BTB2_POZ_RHOBTB1 cd18358
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 35-109 4.27e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349667 [Multi-domain]  Cd Length: 126  Bit Score: 46.11  E-value: 4.27e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 742799281  35 RLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGEL 109
Cdd:cd18358   10 RIKECLSKGTFSDVTFKLDDGTINAHKPLLICSCEWMAAMFGGSFIESANSEVVLPNISKVSMQAVLDYLYTKQL 84
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 146-223 5.32e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 44.62  E-value: 5.32e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 742799281 146 DNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQ-NVSMQKLCvyLSSSEVQRECEHDLLQAALQWLTQQPE 223
Cdd:cd18480    4 SNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLElNFEVLEKI--LEADELNVPDEEAVLKAVLRWTKHDLE 80
BTB_POZ_KBTBD13 cd18320
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 53-127 5.49e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 13 (KBTBD13); KBTBD13 is a muscle specific protein. Its autosomal dominant mutations may cause Nemaline Myopathy (NEM). KBTBD13 may act as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that functions as a muscle specific ubiquitin ligase, and thereby implicating the ubiquitin proteasome pathway in the pathogenesis of KBTBD13-associated NEM. KBTBD13 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349629 [Multi-domain]  Cd Length: 83  Bit Score: 44.72  E-value: 5.49e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 742799281  53 DEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQ 127
Cdd:cd18320    9 EEQLFTVDKALLVENSEYFRALFRSGMRECTQDEIRLQGLSARGFRIMLRVLAGERPILNGEEILQAIECAAFLQ 83
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 474-519 6.38e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 43.37  E-value: 6.38e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 742799281  474 SESGVAVWEGRIYILGGYSWENtaFSKTVQVYDREADKWSRGVDLP 519
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFDGNQ--SLNSVEVYDPETNTWSKLPSMP 46
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 141-241 6.85e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 45.13  E-value: 6.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 141 QEVSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQnVSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQ 220
Cdd:cd18469    1 QQIDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQ-LEKERLVACLGDDLLQVRDEQSRLEAVLRWVGH 79

                         90       100
                 ....*....|....*....|..
gi 742799281 221 QPE-REAHARQVLENIHFPLIP 241
Cdd:cd18469   80 DPQaRAAHLPELLSLVHLSLLT 101
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-135 1.26e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 44.54  E-value: 1.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMReafQKEVELIGASYIGLKAVVDFLYGG 107
Cdd:cd18218    1 HSDRLLHLAARLRPAGALCDTLITVGSQEFPAHSLVLAGASQQLGRQLTNPNP---GQWCLGEGISPSTFKQLLDFVYGE 77

                         90       100
                 ....*....|....*....|....*...
gi 742799281 108 ELVLDGGNIDYVLETAHLLQIWTVVDFC 135
Cdd:cd18218   78 SVEVQPGELRPLLEAARALEVESLEEAC 105
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 47-137 1.52e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 44.19  E-value: 1.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  47 DVVLVADEQRVPAHRnlLAVC-SDYFNSMFTIGMREAFQKEVEL------IGASyiGLKAVVDFLYGGELVLDGGNIDYV 119
Cdd:cd18305   17 DITICALGREWKLHK--IYLCqSGYFASMFSGSWKESKETVINLeipddnITVE--ALNVVFGSLYRDEIEIKPSRVVSI 92

                         90
                 ....*....|....*...
gi 742799281 120 LETAHLLQIWTVVDFCCE 137
Cdd:cd18305   93 LAAATLLQLDGLIQQCSE 110
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 168-238 1.77e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 43.45  E-value: 1.77e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 742799281 168 DGFILNHFGTLSFTPDFLQnVSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQQPE-REAHARQVLENIHFP 238
Cdd:cd18448   27 DKYACDHFNEVVECEEFVS-ISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDPQhRKRHLDDLLSQVRLP 97
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 170-249 2.24e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 43.76  E-value: 2.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 170 FILNHFGTLSFTPDFLqNVSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQQPE-REAHARQVLENIHFPLIPKNDLLHR 248
Cdd:cd18445   28 YTEQHFSEVVKGEEFL-LLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPEnRKEHLAELLEHVRLPLLSPEYLVQR 106


                 .
gi 742799281 249 V 249
Cdd:cd18445  107 V 107
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 147-234 2.29e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 43.07  E-value: 2.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 147 NYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQnVSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQQPE-RE 225
Cdd:cd18455    4 NCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLE-LSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEeRK 82


                 ....*....
gi 742799281 226 AHARQVLEN 234
Cdd:cd18455   83 VHLKDLMSS 91
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-108 3.06e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 43.68  E-value: 3.06e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 742799281  42 RGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGE 108
Cdd:cd18345   15 RSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGK 81
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 47-128 3.66e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 42.86  E-value: 3.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  47 DVVLVADEQRVPAHRNLLAVCSDYFNSmftigmrEAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLL 126
Cdd:cd18275    6 DLVIEVSGQRIRAHKSVLAAKSDYFRA-------RLSRDILKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFL 78


                 ..
gi 742799281 127 QI 128
Cdd:cd18275   79 QM 80
PLN02153 PLN02153
epithiospecifier protein
 324-514 4.07e-05

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 45.75  E-value: 4.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 324 QWVKETPL----PARRSHHCVAVLGGFIFIAGGSFSRDNGGDAAsnlLYRFTY-----------GHAGTI---------Y 379
Cdd:PLN02153   8 GWIKVEQKggkgPGPRCSHGIAVVGDKLYSFGGELKPNEHIDKD---LYVFDFnthtwsiapanGDVPRIsclgvrmvaV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 380 KDFVYISGGHDYQIGpyRKNLLCYDHRTDVW-------EERRPmtTARGWHSMCSLGDSIYSIGGSDDN--IESMERFDV 450
Cdd:PLN02153  85 GTKLYIFGGRDEKRE--FSDFYSYDTVKNEWtfltkldEEGGP--EARTFHSMASDENHVYVFGGVSKGglMKTPERFRT 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 742799281 451 lgVEAYSPQCNQWTRVaPLLHANSE----SGVAVWEGRIYILGGYSW------ENTAFSKTVQVYDREADKWSR 514
Cdd:PLN02153 161 --IEAYNIADGKWVQL-PDPGENFEkrggAGFAVVQGKIWVVYGFATsilpggKSDYESNAVQFFDPASGKWTE 231
BTB_POZ_ZBTB6 cd18197
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-139 4.16e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349506 [Multi-domain]  Cd Length: 116  Bit Score: 42.94  E-value: 4.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  23 YRWADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTigMREAFQKEVELIGASYIGLKAVVD 102
Cdd:cd18197    3 FKFEQQGDAVLQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRDQFL--LNQSKQVRITILQSAEVGRKLLLS 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 742799281 103 fLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYL 139
Cdd:cd18197   81 -CYTGALEVKKKELLKYLTAASYLQMVHIVEKCTEAL 116
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 423-469 6.05e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 40.67  E-value: 6.05e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 742799281  423 HSMCSLGDSIYSIGGSDDNiesmERFDVlgVEAYSPQCNQWTRVAPL 469
Cdd:pfam01344   5 AGVVVVGGKIYVIGGFDGN----QSLNS--VEVYDPETNTWSKLPSM 45
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 142-239 6.56e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 41.96  E-value: 6.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 142 EVSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQnVSMQKLCVYLSSSEVQRECEHDLLQAALQWLT-Q 220
Cdd:cd18447    1 QVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQ-LDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKyD 79

                         90
                 ....*....|....*....
gi 742799281 221 QPEREAHARQVLENIHFPL 239
Cdd:cd18447   80 EPNRQPYMVDILAKVRFPL 98
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 166-245 7.84e-05

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 42.08  E-value: 7.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 166 FIDGFILNHFGTLSFTPDFLqNVSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQQ-PEREAHARQVLENIHFPLIPKND 244
Cdd:cd18466   24 FTENYIHVHFLEVQSGEEFL-GLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDvGKRKKHVVEVLEPVRFPLLPPQR 102


                 .
gi 742799281 245 L 245
Cdd:cd18466  103 L 103
BTB_POZ_ZBTB25_ZNF46_KUP cd18213
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-75 9.43e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349522 [Multi-domain]  Cd Length: 128  Bit Score: 42.19  E-value: 9.43e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 742799281  26 ADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMF 75
Cdd:cd18213    2 SSHSLVLLQQLNMQREFGFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIF 51
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 146-240 9.95e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 41.71  E-value: 9.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 146 DNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFlQNVSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQQPERE 225
Cdd:cd18460    4 SNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQF-ERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPKHR 82

                         90
                 ....*....|....*.
gi 742799281 226 AHA-RQVLENIHFPLI 240
Cdd:cd18460   83 QHFwPELLQHVRLPFV 98
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 143-240 1.04e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 41.40  E-value: 1.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 143 VSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQnVSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQQP 222
Cdd:cd18470    1 INVENCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLK-LTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFDQ 79

                         90
                 ....*....|....*...
gi 742799281 223 EREAHARQVLENIHFPLI 240
Cdd:cd18470   80 KRVKYAADLLSNIRFGTI 97
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-126 1.04e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 41.93  E-value: 1.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  46 CDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNID------YV 119
Cdd:cd18280   15 ADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYKDELPDDVEPAGsdssslDT 94


                 ....*..
gi 742799281 120 LETAHLL 126
Cdd:cd18280   95 TMAQHLL 101
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 147-217 1.41e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 40.45  E-value: 1.41e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 742799281 147 NYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQnVSMQKLCVYLSSSEVQRECEHDLLQAALQW 217
Cdd:cd18463    6 NCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLE-LCKDELIEYISNDELVVPKEEEVFEAVMRW 75
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-107 1.52e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 41.75  E-value: 1.52e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 742799281  42 RGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGG 107
Cdd:cd18279   15 NSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTG 80
PLN02193 PLN02193
nitrile-specifier protein
 383-514 1.86e-04

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 44.18  E-value: 1.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 383 VYISGGHDYQigpyRK--NLLCYDHRTDVWEERRPMT---TARGWHSMCSLGDSIYSIGGsddnIESMERFDVLgvEAYS 457
Cdd:PLN02193 231 LYVFGGRDAS----RQynGFYSFDTTTNEWKLLTPVEegpTPRSFHSMAADEENVYVFGG----VSATARLKTL--DSYN 300

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 458 PQCNQWTRVA-PL--LHANSESGVAVWEGRIYILGGYsweNTAFSKTVQVYDREADKWSR 514
Cdd:PLN02193 301 IVDKKWFHCStPGdsFSIRGGAGLEVVQGKVWVVYGF---NGCEVDDVHYYDPVQDKWTQ 357
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 147-241 2.17e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 40.60  E-value: 2.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 147 NYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFlQNVSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQQPE-RE 225
Cdd:cd18514    5 NCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDF-YSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLEkRK 83

                         90
                 ....*....|....*.
gi 742799281 226 AHARQVLENIHFPLIP 241
Cdd:cd18514   84 DYLPELLRNVRLALLP 99
Kelch_3 pfam13415
Galactose oxidase, central domain;
482-529 3.12e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 38.43  E-value: 3.12e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 742799281  482 EGRIYILGGYSWENTAFSKTVQVYDREADKWSRGVDLPKAIAGGSACV 529
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATY 48
BTB_POZ_ZBTB2 cd18193
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-75 4.17e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349502 [Multi-domain]  Cd Length: 115  Bit Score: 40.36  E-value: 4.17e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 742799281  26 ADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMF 75
Cdd:cd18193    2 ANHGLILLQQLNAQREFGFLCDCTVAIGDVYFKAHKSVLASFSNYFKMLF 51
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 47-125 4.75e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 39.04  E-value: 4.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  47 DVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVEL--IGASYIGLKAVVDFLYGGelVLDGGNIDYVLETAH 124
Cdd:cd18190    1 DLVFCVGGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFeeNGISIEAMRAVIDFSVTG--RLDLFSVENVHEVLE 78


                 .
gi 742799281 125 L 125
Cdd:cd18190   79 L 79
BACK_KLHL14 cd18453
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also ...
 143-250 4.80e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also termed protein interactor of Torsin-1A, or Printor, or protein interactor of torsinA, is a novel ATP-free form of torsinA-interacting protein implicated in dystonia pathogenesis.


Pssm-ID: 350528  Cd Length: 102  Bit Score: 39.62  E-value: 4.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 143 VSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFtpdflqnvsmQKLCVYLSSSEVQRECEHDLLQAALQWLTQQP 222
Cdd:cd18453    1 ISVQNYKQVCKIAALHGLEETKKLANKYLVEDVLLLNF----------EEMRAMLDSLPPPVESELALFQMSVLWLEHDR 70

                         90       100
                 ....*....|....*....|....*....
gi 742799281 223 E-REAHARQVLENIHFPLIPKNDLLHRVK 250
Cdd:cd18453   71 EtRMQYAPDLMKRLRFALIPAPELVERVQ 99
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 144-218 6.96e-04

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 38.54  E-value: 6.96e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 742799281 144 SEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLqNVSMQKLCVYLSSSEVQRECEHDLLQAALQWL 218
Cdd:cd18508    1 DATNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFL-SLDHESLTELISSDRLNVPSEERVYEAAVAWL 74
Kelch_6 pfam13964
Kelch motif;
423-472 7.37e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 37.70  E-value: 7.37e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 742799281  423 HSMCSLGDSIYSIGGSDDNIESMERfdvlgVEAYSPQCNQWTRVAPLLHA 472
Cdd:pfam13964   5 HSVVSVGGYIYVFGGYTNASPALNK-----LEVYNPLTKSWEELPPLPTP 49
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 36-75 7.62e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 38.81  E-value: 7.62e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 742799281  36 LNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMF 75
Cdd:cd18301    9 LDEADEGDNIHDVVFQVGGKTFPAHKFILASRSDYFRKLF 48
Kelch smart00612
Kelch domain;
432-480 7.75e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 37.54  E-value: 7.75e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 742799281   432 IYSIGGSDdnieSMERFDVlgVEAYSPQCNQWTRVAPLLHANSESGVAV 480
Cdd:smart00612   2 IYVVGGFD----GGQRLKS--VEVYDPETNKWTPLPSMPTPRSGHGVAV 44
Kelch_6 pfam13964
Kelch motif;
478-521 9.52e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 37.31  E-value: 9.52e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 742799281  478 VAVWEGRIYILGGYSWENTAFSKtVQVYDREADKWSRGVDLPKA 521
Cdd:pfam13964   7 VVSVGGYIYVFGGYTNASPALNK-LEVYNPLTKSWEELPPLPTP 49
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 332-371 1.10e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 36.77  E-value: 1.10e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 742799281  332 PARRSHHCVAVLGGFIFIAGGSFSRDNGGdaaSNLLYRFT 371
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGEGQP---SDDVYVLS 37
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 143-222 1.60e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 37.49  E-value: 1.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 143 VSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQnVSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQQP 222
Cdd:cd18474    1 IGANNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLK-LELQLVLELLADDSLAVRSEEVVLEAALRWVDADP 79
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 47-112 1.66e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 38.39  E-value: 1.66e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 742799281  47 DVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGELVLD 112
Cdd:cd18298   14 DLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSYPVYYAFLRYLYTDQVDLP 79
Kelch smart00612
Kelch domain;
317-345 1.67e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 36.38  E-value: 1.67e-03
                           10        20
                   ....*....|....*....|....*....
gi 742799281   317 YLDAKSEQWVKETPLPARRSHHCVAVLGG 345
Cdd:smart00612  19 VYDPETNKWTPLPSMPTPRSGHGVAVING 47
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 169-241 1.98e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 37.65  E-value: 1.98e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 742799281 169 GFILNHFGTLSFTPDFLQnVSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQQPE-REAHARQVLENIHFPLIP 241
Cdd:cd18515   26 RMCLSNFQTICKTEDFLQ-LPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKkRHCYLSELLQTVRLALLP 98
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-140 2.09e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 38.15  E-value: 2.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  55 QRVPAHRNLLAVCSDYFNSMFTIGMREAfQKEVELIGASYIGLKAVVDFLYGGELVLDGgniDYVLETAHLLQIWTV--- 131
Cdd:cd18282   21 QRIPAHKYVLATGSSVFYAMFYGGLAEN-KNEIEIPDVEPAAFLNLLRYLYCDEIDLEP---DTVLATLYAAKKYLVphl 96


                 ....*....
gi 742799281 132 VDFCCEYLE 140
Cdd:cd18282   97 ARACVQFLE 105
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 170-241 2.26e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 37.51  E-value: 2.26e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 742799281 170 FILNHFGTLSFTPDFLQnVSMQKLCVYLSSSEVQRECEHDLLQAALQWL-TQQPEREAHARQVLENIHFPLIP 241
Cdd:cd18477   28 FICAHFTLVAKDEDFLG-LSADELIAIISSDGLNVEKEEAVFEAVMKWVrEAKENRQKALPTVFESIRFRLLP 99
BTB_POZ_ARMC5 cd18191
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 47-106 2.75e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in armadillo repeat-containing protein 5 (ARMC5); ARMC5 plays a role in steroidogenesis, and modulates the expression and cortisol production of steroidogenic enzymes. It negatively regulates adrenal cells survival. It contains armadillo (ARM) repeats and a BTB domain, which is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349500 [Multi-domain]  Cd Length: 100  Bit Score: 37.48  E-value: 2.75e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 742799281  47 DVVLVADE-QRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYG 106
Cdd:cd18191    3 DLRFLLDGgTQLPASRAALTGASEVFRAMLEGGFAEAQQDLVPLRQVPSGAFLPVLHYLHG 63
Kelch_3 pfam13415
Galactose oxidase, central domain;
380-428 3.97e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 35.34  E-value: 3.97e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 742799281  380 KDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSL 428
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 147-274 6.54e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 36.99  E-value: 6.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281 147 NYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDF--LQNVSMQKLcvyLSSSEVQRECEHDLLQAALQWLTQQPE- 223
Cdd:cd18452    5 NCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFmlLSQEEVEKL---IKSDEIQVDSEEPVFEAVLNWVKHDKEe 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 742799281 224 REAHARQVLENIHFPLI-PK-------NDLLHRvkpavCSLlpkeaNCEGFIEEAVRYH 274
Cdd:cd18452   82 REDYLPELLQYVRLPLLsPRyitdvvdAEPLIR-----CSL-----ECRDLVDEAKKFH 130
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 33-117 8.41e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 36.46  E-value: 8.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742799281  33 LQRLNEQrlrGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMF--------TIGMREafqkevELIgaSYIGLKAVVDFL 104
Cdd:cd18295   10 LRRLLEQ---GSYSDVTFNVHGESFPAHRCILSARSPYFAEMFetkwkdkrEINLKH------PLV--NPDAFRALLQYL 78

                         90
                 ....*....|...
gi 742799281 105 YGGELVLDGGNID 117
Cdd:cd18295   79 YTGRLEIHVDDVE 91
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 187-240 8.90e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 35.85  E-value: 8.90e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 742799281 187 NVSMQKLCVYLSSSEVQRECEHDLLQAALQWL-TQQPEREAHARQVLENIHFPLI 240
Cdd:cd18468   43 SISKDDIVEYLSHDSLNTKAEELVFETAIKWLkKDPKNRKQHIAELLAVVRLPFI 97
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 172-241 9.22e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 35.94  E-value: 9.22e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 742799281 172 LNHFGTLSFTPDFLQnVSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQQ-PEREAHARQVLENIHFPLIP 241
Cdd:cd18464   29 LANFTTLRKTEDFLS-LPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDlPRRHEVLPELLRSVRLALLP 98
Kelch_6 pfam13964
Kelch motif;
370-420 9.66e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 34.62  E-value: 9.66e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 742799281  370 FTYGHAGTIYKDFVYISGGHDYQIGPYRKnLLCYDHRTDVWEERRPMTTAR 420
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASPALNK-LEVYNPLTKSWEELPPLPTPR 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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