Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|...
gi 748983223  298 FMCLLCGKTFTQKGNLHRHMRVH 320
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983223 269 LQWHHQCPKCTRVFRHLENYANHLKM-HKLFMCLLCGKT----------FTQKGnLHRHMRVHAGIKPFQ----CKICGK 333
Cdd:COG5236  150 LSFKCPKSKCHRRCGSLKELKKHYKAqHGFVLCSECIGNkkdfwneirlFRSST-LRDHKNGGLEEEGFKghplCIFCKI 228

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 748983223 334 TFSQkcslQDHLNLHSGDKPHKCNYCDMVFAHKPVLRKHLKQL--HGKNS 381
Cdd:COG5236  229 YFYD----DDELRRHCRLRHEACHICDMVGPIRYQYFKSYEDLeaHFRNA 274

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983223   23 MNKLREENKFCDVTVLIDDIEVQGHKIVFAAGSPFLRDQFlLNDSREVKISILQ----SSEVGRQLLLSCYSGVLEfPEM 98
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALF-SGQESESSVSEITlddvSPEDFEALLEFMYTGKLI-SEE 78

                          90       100
                  ....*....|....*....|....*
gi 748983223   99 ELVNYLTAASFLQMSHIVERCTQAL 123
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFL 103

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.

                          10        20
                  ....*....|....*....|...
gi 748983223  298 FMCLLCGKTFTQKGNLHRHMRVH 320
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23

kelch-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983223  31 KFCDVTVLI--DDIEVQGHKIVFAAGSPFLRdQFLLNDSREVKISILQSSEVGRQLLLSCYSGVLEFPEMELVNYLTAAS 108
Cdd:PHA03098   8 KFCDESIIIvnGGGIIKVHKIILSSSSEYFK-KMFKNNFKENEINLNIDYDSFNEVIKYIYTGKINITSNNVKDILSIAN 86

                         90
                 ....*....|....*....
gi 748983223 109 FLQMSHIVERCTQALWKFI 127
Cdd:PHA03098  87 YLIIDFLINLCINYIIKII 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983223   8 LHFKFENYGDSMLQKMNKLREENKFCDVTVLIDDIEVQGHKIVFAAGSPFLRDQFLLNDSREVKISILQSSEVGRQLLLS 87
Cdd:cd18197    1 LHFKFEQQGDAVLQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRDQFLLNQSKQVRITILQSAEVGRKLLLS 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 748983223  88 CYSGVLEFPEMELVNYLTAASFLQMSHIVERCTQAL 123
Cdd:cd18197   81 CYTGALEVKKKELLKYLTAASYLQMVHIVEKCTEAL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983223   8 LHFKFENYGDSMLQKMNKLREENKFCDVTVLIDDIEVQGHKIVFAAGSPFLRDQFLLNDSREVKISILQSSEVGRQLLLS 87
Cdd:cd18227    1 FRVEFPDFSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCDQVLLKNSRRIVLPDVMNPRVFENILLS 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 748983223  88 CYSGVLEFPEMELVNYLTAASFLQMSHIVERCTQAL 123
Cdd:cd18227   81 CYTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983223   8 LHFKFENYGDSMLQKMNKLREENKFCDVTVLIDDIEVQGHKIVFAAGSPFLRDQFLLNDSREVKISILQSSEVGRQLLLS 87
Cdd:cd18220    1 IQFDVPEYSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISVIKNPNVFEQLLSF 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 748983223  88 CYSGVLEFPEMELVNYLTAASFLQMSHIVERCTQAL 123
Cdd:cd18220   81 CYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQIL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983223  15 YGDSMLQKMNKLREENKFCDVTVLIDDIEVQGHKIVFAAGSPFLRDQFLLNDSrEVKISILQSSEVGRQLLLSCYSGVLE 94
Cdd:cd18229    1 FSKSLLETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFFHDKLLLGHS-EIEVPPVVPAQTVRQLVEFMYSGSLV 79

                         90       100
                 ....*....|....*....|....*..
gi 748983223  95 FPEMELVNYLTAASFLQMSHIVERCTQ 121
Cdd:cd18229   80 VAQSEALQILTAASILQIKTVIDECTQ 106

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983223   23 MNKLREENKFCDVTVLIDDIEVQGHKIVFAAGSPFLRDQFlLNDSREVKISILQ----SSEVGRQLLLSCYSGVLEfPEM 98
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALF-SGQESESSVSEITlddvSPEDFEALLEFMYTGKLI-SEE 78

                          90       100
                  ....*....|....*....|....*
gi 748983223   99 ELVNYLTAASFLQMSHIVERCTQAL 123
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFL 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983223   5 SDLLHFKFENYGDSMLQKMNKLREENKFCDVTVLIDDIEVQGHKIVFAAGSPFLRDQFLLNDSREVKISILQSSEVGRQL 84
Cdd:cd18289    2 SQMLHIEIPNFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPATVPPACFQQI 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 748983223  85 LLSCYSGVLEFPEMELVNYLTAASFLQMSHIVERCTQALWKFIKP 129
Cdd:cd18289   82 LSFCYTGKLTMAASEQLVVMYTAGFLQIQHIVERGTDLMFKVSSP 126

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983223  32 FCDVTVLIDDIEVQGHKIVFAAGSPFLRDQFLLN----DSREVKISILqSSEVGRQLLLSCYSGVLEFPEMELVNYLTAA 107
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGmkesSSSEIELDDV-SPEAFEALLDYIYTGELELSEENVEELLAAA 79

                 ...
gi 748983223 108 SFL 110
Cdd:cd18186   80 DKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983223   8 LHFKFENYGDSMLQKMNKLREENKFCDVTVLIDDIEVQGHKIVFAAGSPFLRDQFLLNDSREVKISILQSSEVGRQLLLS 87
Cdd:cd18290    3 LQMEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAVQPQSFQQILSF 82

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 748983223  88 CYSGVLEFPEMELVNYLTAASFLQMSHIVERCTQALWK 125
Cdd:cd18290   83 CYTGRLSMNVGDQFLLMYTAGFLQIQEIMEKGTEFFLK 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983223  15 YGDSMLQKMNKLREENKFCDVTVLIDDIEVQGHKIVFAAGSPFLRDQFLLNDSREVKIS------ILQSSEVGRQ----L 84
Cdd:cd18228    2 HSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLVLVspagkcVLDLHHVTVTgfapL 81

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 748983223  85 LLSCYSGVLEFPEMELVNYLTAASFLQMSHIVERCTQ 121
Cdd:cd18228   82 LEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSE 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983223  14 NYGDSMLQKMNKLREENKFCDVTVLIDDIEVQGHKIVFAAGSPFLRDQFLlNDSREVKISILQSSEVG----RQLLLSCY 89
Cdd:cd18336    1 NHAEQTFRKMENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFT-NDVREAKQEEIKMEGVDpdalKALVHYAY 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 748983223  90 SGVLEFPEMELVNYLTAASFLQMSHIVERCTQALWKFIKP 129
Cdd:cd18336   80 TGVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHP 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983223  15 YGDSMLQKMNKLREENKFCDVTVLIDDIEVQGHKIVFAAGSPFLRDQFLLNDSREVKISILQSSEVGRQLLLS-CYSGVL 93
Cdd:cd18217    1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTEDNIVFLDQSQVSADGFQKLLEfIYTGNL 80

                         90       100
                 ....*....|....*....|....*..
gi 748983223  94 EFPEMELVNYLTAASFLQMSHIVERCT 120
Cdd:cd18217   81 NLDSWNVAEIHQAASYLGMEEVVAKCK 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983223  11 KFENYGDSMLQKMNKLREENKFCDVTVLIDDIEVQGHKIVFAAGSP----FLRDQFLLNDSREVKISILQSSEVGrQLLL 86
Cdd:cd18324    2 EFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMyfhlFYKDQLDKRDIVHLNSDIVTAPAFA-LLLE 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 748983223  87 SCYSGVLEFPEMELVNYLTAASFLQMSHIVERCTQALwkfiKPKQPMDSKEGCEPQSASPQSKEQQGDARG 157
Cdd:cd18324   81 FMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKL----KEKATTEADSTKKEEDASSCSDKVESFSSG 147

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983223    34 DVTVLIDDIEVQGHKIVFAAGSPFLRDQFLLN----DSREVKISILqSSEVGRQLLLSCYSGVLEFPEMELVNYLTAASF 109
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDfkesDKSEIYLDDV-SPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|....*...
gi 748983223   110 LQMSHIVERCTQALWKFI 127
Cdd:smart00225  80 LQIPGLVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983223  15 YGDSMLQKMNKLREENKFCDVTVLIDDIEVQGHKIVFAAGSPFLRDQFL--LNDSREVKISILQSSEVGRQLLLS-CYSG 91
Cdd:cd18255    1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTggMRESSQDEIELKGVSAKGLKHILDfAYTS 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 748983223  92 VLEFPEMELVNYLTAASFLQMSHIVERCTQAL 123
Cdd:cd18255   81 ELTLDLDCIQDVLGAAVHLQMLPVVELCEEFL 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983223  19 MLQKMNKLREENKFCDVTVLIDDIEVQGHKIVFAAGSPFLRD----QFLLNDSREVKISILQ-SSEVGRQLLLSCYSGVL 93
Cdd:cd18245    1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAklnyNPPKDDGSTYKIELEGiSVEVMEEILDYIYTGQI 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 748983223  94 EFPEMELVNYLTAASFLQMSHIVERCTQAL 123
Cdd:cd18245   81 KLSEDNIQDIVQAADLLLMTDLKDLCCEFL 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983223  14 NYGDSMLQKMNKLREENKFCDVTVLIDDIEVQGHKIVFAAGSPFLRDQFLLNDSREVKISILQSSEVGrQLLLSCYSGVL 93
Cdd:cd18225    5 NYSRQLLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLDSTDTISIDASVVSPEEFA-LLLEMVYTGKL 83

                         90       100       110
                 ....*....|....*....|....*....|
gi 748983223  94 EFPEMELVNYLTAASFLQMSHIVERCTQAL 123
Cdd:cd18225   84 PPGKHNFTKIISVADSLQMFDVAVSCKNLL 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983223  15 YGDSMLQKMNKLREENKFCDVTVLIDDIEVQGHKIVFAAGSPFLRDQFL--LNDSREVKISILQSSEVGRQLLLS-CYSG 91
Cdd:cd18250    4 HALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAgeLRESRADRVVLHGVSAEILGLLLDfSYTG 83

                         90       100       110
                 ....*....|....*....|....*....|..
gi 748983223  92 VLEFPEMELVNYLTAASFLQMSHIVERCTQAL 123
Cdd:cd18250   84 RVTVTQDNVEALLRAADLFQFPSVKEACCAYL 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983223  12 FENYGDSMLQKMNKLREENKFCDVTVLIDDIEVQGHKIVFAAGSPFLRDQFLlnDSRE-VKISILQSSEVGrQLLLSCYS 90
Cdd:cd18206    2 FPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFV--DQKDvVHLDISNAAGLG-QVLEFMYT 78

                         90       100       110
                 ....*....|....*....|....*....|
gi 748983223  91 GVLEFPEMELVNYLTAASFLQMSHIVERCT 120
Cdd:cd18206   79 AKLSLSPENVDDVLAVATFLQMQDIVTACH 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983223  15 YGDSMLQKMNKLREENKFCDVTVLIDDIEVQGHKIVFAAGSPFLRDqFLLNDSREVKISILQSSEVGRQLLLS-CYSGVL 93
Cdd:cd18260    1 YGANLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRN-ILKKDPSLQRVELNDISPLGLATVITyAYTGKL 79

                         90       100       110
                 ....*....|....*....|....*....|
gi 748983223  94 EFPEMELVNYLTAASFLQMSHIVERCTQAL 123
Cdd:cd18260   80 TLSLYTIGSTISAASYLQIHALVKMCCDFL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983223  13 ENYGDSMLQKMNKLREENKFCDVTVLIDDIEVQGHKIVFAAGSPFLRDQFLLN----DSREVKISILQSSEVgRQLLLSC 88
Cdd:cd18271    5 ECHGQQILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNmkerDDGSVTISNLSPKAV-KAFLDYA 83

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 748983223  89 YSGVLEFPEMELVNYLTAASFLQMSHIVERCTQALWKFI 127
Cdd:cd18271   84 YTGKAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSI 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983223  15 YGDSMLQKMNKLREENKFCDVTVLIDDIEVQGHKIVFAAGSPFLRDQFL--LNDSREVKISILQSSEVGRQLLLS-CYSG 91
Cdd:cd18270    9 YAVSLLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMsgLSESKQTHVHLRNVDAATLQIIITyAYTG 88

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 748983223  92 VLEFPEMELVNYLTAASFLQMSHIVERCTQALWKFIKPK 130
Cdd:cd18270   89 NLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAE 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983223  19 MLQKMNKLREENKFCDVTVLIDDIEVQGHKIVFAAGSPFLRDQFLLNDSREVKISILQSS--EVGRQLLLS-CYSGVLEF 95
Cdd:cd18332    6 VLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTLPSGleARGFQLLLDfMYTSRLPL 85

                         90       100
                 ....*....|....*....|....
gi 748983223  96 PEMELVNYLTAASFLQMSHIVERC 119
Cdd:cd18332   86 TPRTVPAVLAAATYLQMEHVVETC 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748983223  17 DSMLQKMNKLREENKFCDVTVLIDDIEVQGHKIVFAAGSPFLRDQfLLNDSREVKISI-LQSSEVGRQLLLSCYSGVLEF 95
Cdd:cd18218    3 DRLLHLAARLRPAGALCDTLITVGSQEFPAHSLVLAGASQQLGRQ-LTNPNPGQWCLGeGISPSTFKQLLDFVYGESVEV 81

                         90       100
                 ....*....|....*....|....*...
gi 748983223  96 PEMELVNYLTAASFLQMSHIVERCTQAL 123
Cdd:cd18218   82 QPGELRPLLEAARALEVESLEEACWRAL 109