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Conserved domains on  [gi|751368119|ref|NP_001291426|]
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centrosomal protein 20 isoform 2 [Homo sapiens]

Protein Classification

LisH domain-containing protein( domain architecture ID 1007505)

LIS1 homology (LisH) domain-containing protein similar to Homo sapiens centrosomal protein 20 which is involved in the biogenesis of cilia and required for the recruitment of PLK1 to centrosomes and S phase progression

CATH:  1.20.960.40
Gene Ontology:  GO:0005515
SCOP:  3001444

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LisH_2 super family cl29685
LisH;
43-89 3.45e-07

LisH;


The actual alignment was detected with superfamily member pfam09398:

Pssm-ID: 475244  Cd Length: 81  Bit Score: 44.08  E-value: 3.45e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 751368119   43 RPSLSHENL----------LINELIREYLEFNKYKYTASVLIADDHLRKEEQKSTNI 89
Cdd:pfam09398   1 KPPLCNENLkkvqstkegrLVAELIREFLEFFELDYTASVFSPEANLPEEILDRDAL 57
 
Name Accession Description Interval E-value
FOP_dimer pfam09398
FOP N terminal dimerization domain; Fibroblast growth factor receptor 1 (FGFR1) oncogene ...
 43-89 3.45e-07

FOP N terminal dimerization domain; Fibroblast growth factor receptor 1 (FGFR1) oncogene partner (FOP) is a centrosomal protein that is involved in anchoring microtubules to subcellular structures. This domain includes a Lis-homology motif. It forms an alpha helical bundle and is involved in dimerization.


Pssm-ID: 312785  Cd Length: 81  Bit Score: 44.08  E-value: 3.45e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 751368119   43 RPSLSHENL----------LINELIREYLEFNKYKYTASVLIADDHLRKEEQKSTNI 89
Cdd:pfam09398   1 KPPLCNENLkkvqstkegrLVAELIREFLEFFELDYTASVFSPEANLPEEILDRDAL 57
 
Name Accession Description Interval E-value
FOP_dimer pfam09398
FOP N terminal dimerization domain; Fibroblast growth factor receptor 1 (FGFR1) oncogene ...
 43-89 3.45e-07

FOP N terminal dimerization domain; Fibroblast growth factor receptor 1 (FGFR1) oncogene partner (FOP) is a centrosomal protein that is involved in anchoring microtubules to subcellular structures. This domain includes a Lis-homology motif. It forms an alpha helical bundle and is involved in dimerization.


Pssm-ID: 312785  Cd Length: 81  Bit Score: 44.08  E-value: 3.45e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 751368119   43 RPSLSHENL----------LINELIREYLEFNKYKYTASVLIADDHLRKEEQKSTNI 89
Cdd:pfam09398   1 KPPLCNENLkkvqstkegrLVAELIREFLEFFELDYTASVFSPEANLPEEILDRDAL 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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