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Conserved domains on  [gi|751557617|ref|NP_001291458|]
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coiled-coil domain-containing protein 25 isoform 2 [Homo sapiens]

Protein Classification

NFACT family protein( domain architecture ID 10529311)

NFACT (NEMF, FbpA, Caliban, and Tae2) family protein containing a DUF814 domain, may act in ribosome quality control (RQC) by adding a poly-Ala tail to abortively translated proteins to tag them for degradation, or be exported and behave as a fibronectin-binding adhesin associated with virulence; similar to vertebrate coiled-coil domain-containing protein 25 and yeast protein JLP2

PubMed:  24646681

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NFACT-R_1 pfam05670
NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as ...
 1-81 2.17e-33

NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as Fibronectin/fibrinogen binding protein by similarity. This annotation comes from Swiss:O34693 where the N-terminal region is involved in this activity. It is an RNA binding domain of the NFACT (NEMF, FbpA, Caliban, and Tae2) proteins. This NFACT-R family is found in two eukaryotic gene contexts: fused to the NFACT-N and NFACT-C domains in the NFACT protein involved in the ribosomal quality control pathway which contributes to CAT-tailing and as a standalone domain. Additionally this domain contains a conserved motif D/E-X-W/Y-X-H that may be functionally important.


:

Pssm-ID: 428576 [Multi-domain]  Cd Length: 111  Bit Score: 110.78  E-value: 2.17e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751557617    1 MVFYFTSSSVnssaYTIYMGKDKYENEDLIKHGWPE-DIWFHVDKLSSAHVYLRLHKGeniEDIPKEVLMDCAHLVKANS 79
Cdd:pfam05670   1 KFYWFVSSEG----YLVIGGRDKQENELLIKKYLEEgDLWFHADKHGSAHVYLKLPEG---EDIPPETLEEAAQLAKANS 73


                  ..
gi 751557617   80 IQ 81
Cdd:pfam05670  74 IA 75
 
Name Accession Description Interval E-value
NFACT-R_1 pfam05670
NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as ...
 1-81 2.17e-33

NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as Fibronectin/fibrinogen binding protein by similarity. This annotation comes from Swiss:O34693 where the N-terminal region is involved in this activity. It is an RNA binding domain of the NFACT (NEMF, FbpA, Caliban, and Tae2) proteins. This NFACT-R family is found in two eukaryotic gene contexts: fused to the NFACT-N and NFACT-C domains in the NFACT protein involved in the ribosomal quality control pathway which contributes to CAT-tailing and as a standalone domain. Additionally this domain contains a conserved motif D/E-X-W/Y-X-H that may be functionally important.


Pssm-ID: 428576 [Multi-domain]  Cd Length: 111  Bit Score: 110.78  E-value: 2.17e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751557617    1 MVFYFTSSSVnssaYTIYMGKDKYENEDLIKHGWPE-DIWFHVDKLSSAHVYLRLHKGeniEDIPKEVLMDCAHLVKANS 79
Cdd:pfam05670   1 KFYWFVSSEG----YLVIGGRDKQENELLIKKYLEEgDLWFHADKHGSAHVYLKLPEG---EDIPPETLEEAAQLAKANS 73


                  ..
gi 751557617   80 IQ 81
Cdd:pfam05670  74 IA 75
RqcH COG1293
Ribosome quality control (RQC) protein RqcH, Rqc2/NEMF/Tae2 family, contains fibronectin-(FbpA) ...
 12-74 1.22e-07

Ribosome quality control (RQC) protein RqcH, Rqc2/NEMF/Tae2 family, contains fibronectin-(FbpA) and RNA- (NFACT) binding domains [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440904 [Multi-domain]  Cd Length: 578  Bit Score: 47.14  E-value: 1.22e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 751557617  12 SSAYTIYMGKDKYENEDLI-KHGWPEDIWFHVDKLSSAHVYLRLHKgeniEDIPKEVLMDCAHL 74
Cdd:COG1293  464 SDGFLILVGRNNRQNDELTkKYARKNDIWFHAKDIPGSHVIIKTEG----KEPPEETLEEAAQL 523
 
Name Accession Description Interval E-value
NFACT-R_1 pfam05670
NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as ...
 1-81 2.17e-33

NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as Fibronectin/fibrinogen binding protein by similarity. This annotation comes from Swiss:O34693 where the N-terminal region is involved in this activity. It is an RNA binding domain of the NFACT (NEMF, FbpA, Caliban, and Tae2) proteins. This NFACT-R family is found in two eukaryotic gene contexts: fused to the NFACT-N and NFACT-C domains in the NFACT protein involved in the ribosomal quality control pathway which contributes to CAT-tailing and as a standalone domain. Additionally this domain contains a conserved motif D/E-X-W/Y-X-H that may be functionally important.


Pssm-ID: 428576 [Multi-domain]  Cd Length: 111  Bit Score: 110.78  E-value: 2.17e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751557617    1 MVFYFTSSSVnssaYTIYMGKDKYENEDLIKHGWPE-DIWFHVDKLSSAHVYLRLHKGeniEDIPKEVLMDCAHLVKANS 79
Cdd:pfam05670   1 KFYWFVSSEG----YLVIGGRDKQENELLIKKYLEEgDLWFHADKHGSAHVYLKLPEG---EDIPPETLEEAAQLAKANS 73


                  ..
gi 751557617   80 IQ 81
Cdd:pfam05670  74 IA 75
RqcH COG1293
Ribosome quality control (RQC) protein RqcH, Rqc2/NEMF/Tae2 family, contains fibronectin-(FbpA) ...
 12-74 1.22e-07

Ribosome quality control (RQC) protein RqcH, Rqc2/NEMF/Tae2 family, contains fibronectin-(FbpA) and RNA- (NFACT) binding domains [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440904 [Multi-domain]  Cd Length: 578  Bit Score: 47.14  E-value: 1.22e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 751557617  12 SSAYTIYMGKDKYENEDLI-KHGWPEDIWFHVDKLSSAHVYLRLHKgeniEDIPKEVLMDCAHL 74
Cdd:COG1293  464 SDGFLILVGRNNRQNDELTkKYARKNDIWFHAKDIPGSHVIIKTEG----KEPPEETLEEAAQL 523
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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