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Conserved domains on  [gi|751557626|ref|NP_001291459|]
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coiled-coil domain-containing protein 25 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
NFACT-R_1 super family cl47219
NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as ...
1-44 6.42e-17

NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as Fibronectin/fibrinogen binding protein by similarity. This annotation comes from Swiss:O34693 where the N-terminal region is involved in this activity. It is an RNA binding domain of the NFACT (NEMF, FbpA, Caliban, and Tae2) proteins. This NFACT-R family is found in two eukaryotic gene contexts: fused to the NFACT-N and NFACT-C domains in the NFACT protein involved in the ribosomal quality control pathway which contributes to CAT-tailing and as a standalone domain. Additionally this domain contains a conserved motif D/E-X-W/Y-X-H that may be functionally important.


The actual alignment was detected with superfamily member pfam05670:

Pssm-ID: 428576 [Multi-domain]  Cd Length: 111  Bit Score: 70.72  E-value: 6.42e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 751557626    1 MDCAHLVKANSIQ-GCKMNNVNVVYTPWSNLKKTAD---MDVGQIGFH 44
Cdd:pfam05670  63 EEAAQLAKANSIAwGNKQNNISVWYTPASQVSKTGPsgyLDTGSFMFK 110
 
Name Accession Description Interval E-value
NFACT-R_1 pfam05670
NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as ...
1-44 6.42e-17

NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as Fibronectin/fibrinogen binding protein by similarity. This annotation comes from Swiss:O34693 where the N-terminal region is involved in this activity. It is an RNA binding domain of the NFACT (NEMF, FbpA, Caliban, and Tae2) proteins. This NFACT-R family is found in two eukaryotic gene contexts: fused to the NFACT-N and NFACT-C domains in the NFACT protein involved in the ribosomal quality control pathway which contributes to CAT-tailing and as a standalone domain. Additionally this domain contains a conserved motif D/E-X-W/Y-X-H that may be functionally important.


Pssm-ID: 428576 [Multi-domain]  Cd Length: 111  Bit Score: 70.72  E-value: 6.42e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 751557626    1 MDCAHLVKANSIQ-GCKMNNVNVVYTPWSNLKKTAD---MDVGQIGFH 44
Cdd:pfam05670  63 EEAAQLAKANSIAwGNKQNNISVWYTPASQVSKTGPsgyLDTGSFMFK 110
 
Name Accession Description Interval E-value
NFACT-R_1 pfam05670
NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as ...
1-44 6.42e-17

NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as Fibronectin/fibrinogen binding protein by similarity. This annotation comes from Swiss:O34693 where the N-terminal region is involved in this activity. It is an RNA binding domain of the NFACT (NEMF, FbpA, Caliban, and Tae2) proteins. This NFACT-R family is found in two eukaryotic gene contexts: fused to the NFACT-N and NFACT-C domains in the NFACT protein involved in the ribosomal quality control pathway which contributes to CAT-tailing and as a standalone domain. Additionally this domain contains a conserved motif D/E-X-W/Y-X-H that may be functionally important.


Pssm-ID: 428576 [Multi-domain]  Cd Length: 111  Bit Score: 70.72  E-value: 6.42e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 751557626    1 MDCAHLVKANSIQ-GCKMNNVNVVYTPWSNLKKTAD---MDVGQIGFH 44
Cdd:pfam05670  63 EEAAQLAKANSIAwGNKQNNISVWYTPASQVSKTGPsgyLDTGSFMFK 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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