|
Name |
Accession |
Description |
Interval |
E-value |
| SLC5sbd_CHT |
cd11474 |
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ... |
1-390 |
2.47e-165 |
|
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271368 [Multi-domain] Cd Length: 464 Bit Score: 474.70 E-value: 2.47e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 1 MRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGGLYSVA 80
Cdd:cd11474 91 MRRMGLLTLGDFFRQRYGRRVEVLLSIPAVLSYLGWVAAQLVALGLVLSVILGLPVETGILISAAIVLAYTLFGGMWSVA 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 81 YTDVVQLFCIFVGLWISVPFALSHPAVADIG-FTAVHAKYQKPWLGTVdsSEVYSWLDSFLLLMLGGIPWQAYFQRVLSS 159
Cdd:cd11474 171 YTDVVQLIVIFVGLLVLVPFVLTNPGGVDIAsAAAAGKLRFFPWLGTK--SDWLIWIDAWLTLGLGSIPQQDVFQRVLSA 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 160 SSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAYGLPDpktteEADMILPIVLQYLCPVYISFFGLGAVSAAV 239
Cdd:cd11474 249 KSEKTAQRLSLLAGVGYLLFAIPPLLIGLAAASIDPSLTQYGLEE-----DAQLILPLLLQYLTPLWVQVLFLGALLSAV 323
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 240 MSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIVIFPQLLCV 319
Cdd:cd11474 324 MSTADSALLAPSSVFSENIYKPPFRPKASDRELLWVMRISVVVFGAIATLMALTVESIYGLVELASDLVLVGLFVPLLAG 403
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 756761759 320 LFVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQPlifypgyypdDNGIYNQKFPFKTLAMVTSFLTNICIS 390
Cdd:cd11474 404 LYWKRANTYGALAAIIVGLVLRLLGGELLLGLPA----------DIPPQLQGFPFSTLAMVIGSLLPLAVS 464
|
|
| PutP |
COG0591 |
Na+/proline symporter [Amino acid transport and metabolism]; |
1-362 |
2.47e-60 |
|
Na+/proline symporter [Amino acid transport and metabolism];
Pssm-ID: 440356 [Multi-domain] Cd Length: 476 Bit Score: 204.67 E-value: 2.47e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 1 MRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGGLYSVA 80
Cdd:COG0591 95 LRRLGALTIPEFLEKRFGRGLRLLAAIIILLFLLGYLAAQLVALGKLLEALFGIPYWLGILIGALIVLLYTVLGGLRAVA 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 81 YTDVVQLFCIFVGLWISVPFALSHPAvadiGFTAVHAKYQKP----WLGTVDSSEVYSWLDSFLLLMLGGIPWQAYFQRV 156
Cdd:COG0591 175 WTDVLQGILMLVGLILLLIVALSALG----GFGELFAALPAPgllsLFPGLGFTGWLAFLGLFLAIGLGYFGQPHIVQRF 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 157 LSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIgastdwnqtAYGLPDPKTTEEADMILPIVLQYLCPVYISFFGLGAVS 236
Cdd:COG0591 251 LAAKSEKEARKAALIGGLLYLLFYLLAALIGLL---------ARALFPDLPLADPDLALPLLILELLPPGLAGLLLAAIL 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 237 AAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTK-TVYGLWYLSSDLVYIVIFPQ 315
Cdd:COG0591 322 AAAMSTADSQLLAASSVFTRDIYKPFIKPKASDKQLLRVSRLAVLVVGLLALLLALLFPsSILDLVLLAWGGLGAALLPP 401
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 756761759 316 LLCVLFVKGTNTYGAVAGYVSGLFLRITGgepYLYLQPLIFYPGYYP 362
Cdd:COG0591 402 LLLGLFWKRATKAGALAGMIAGLVVVLLW---KLLGGPLGPFGWLYP 445
|
|
| SLC5sbd |
cd10322 |
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ... |
1-362 |
1.69e-59 |
|
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.
Pssm-ID: 271357 [Multi-domain] Cd Length: 454 Bit Score: 202.01 E-value: 1.69e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 1 MRSKGYVTMLD-PFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGGLYSV 79
Cdd:cd10322 92 LRRLGKTTIPEtILERYYSKGLRLLVAIIIIIALIPYLALQLIGGGYILSTLLGIPYTVAVIIAAVIVILYTVFGGMRAV 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 80 AYTDVVQLFCIFVGLWISVPFALSHPAVADIGFTAVHAKYQKPWLGTVDSSEVYSWLDSFLLLMLGGIPWQAYFQRVLSS 159
Cdd:cd10322 172 AWTDVIQGIVMLIGVLVAAIFILSKVGGGGFSALAAALPALLLALGPGGGLGWSTILSLILLTGLGVLALPQVFQRILAA 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 160 SSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNqtayglpdpktTEEADMILPIVLQYLCPVYISFFGLGAVSAAV 239
Cdd:cd10322 252 KDEKTARRAFLLAGLLLLLIGFLVALIGLAARALFPD-----------LENPDLALPTLINSLLPPGLAGLVLAGLLAAA 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 240 MSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIVIFPQLLCV 319
Cdd:cd10322 321 MSTADSLLLAASTLFTRDIYKPLINPKASDKKLLRVSRIAVVVVGVLALLLALLPPSILLLLSLAAGLLAAALFPPLLGG 400
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 756761759 320 LFVKGTNTYGAVAGYVSGLFLRItggepYLYLQPLIFYPGYYP 362
Cdd:cd10322 401 LFWKRATKAGAIAGIIVGLIVTL-----VWLLLPLASPLGIDP 438
|
|
| YidK |
COG4146 |
Uncharacterized membrane permease YidK, sodium:solute symporter family [General function ... |
5-340 |
2.37e-29 |
|
Uncharacterized membrane permease YidK, sodium:solute symporter family [General function prediction only];
Pssm-ID: 443317 [Multi-domain] Cd Length: 444 Bit Score: 119.48 E-value: 2.37e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 5 GYVTMLDPFQQIYGKRMGGLLFIPALMGEMF-WAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTD 83
Cdd:COG4146 103 GIYTMPEFLEKRYDRRTRTILSILFLVSYVFvNLPSVLYAGALALNTIFGVPLWISVIGLGIIAGIYTIFGGLKAVAYTD 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 84 VVQLFCIFVGLWISVPFALShpAVADIGF-------TAVHAKYQKPWLGtvDSSEVYSWLDSFLLLMLGGIP-W---QAY 152
Cdd:COG4146 183 VIQGIGLIIGGLLITVLGLD--AVGDGSVlagwsalLKVPPEKFNMIGP--ADDPDLPWLGIFTGMPILNLFyWgtnQYI 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 153 FQRVLSSSSATYAQVLSFLAAFgcLVMAIPAILI--GAIgastdwnqtAYGLpDPKTTEEADMILPIVLQYLCPVYISFF 230
Cdd:COG4146 259 VQRALGAKNLKEAQKGVLFAGF--LKLLIPFIVVlpGII---------AFVL-FPDGLDNPDQAYPTLVKNLLPVGLKGL 326
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 231 GLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLW-YLSSdlVY 309
Cdd:COG4146 327 VAAALFAAIMSSLASALNSSSTLFTLDIYKKYFNPNASEKQLVKVGRIATVVLAVIAILIAPLIGNADGLFqYIQE--VT 404
|
330 340 350
....*....|....*....|....*....|....*
gi 756761759 310 IVIFPQLLCV----LFVKGTNTYGAVAGYVSGLFL 340
Cdd:COG4146 405 GFFSPPILAVfllgLFWKRVTAKAAKVALIAGIVL 439
|
|
| SLC5sbd_PutP |
cd11475 |
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli ... |
34-339 |
1.34e-27 |
|
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli PutP catalyzes the Na+-coupled uptake of proline with a stoichiometry of 1:1. The putP gene is part of the put operon; this operon in addition encodes a proline dehydrogenase, allowing the use of proline as a source of nitrogen and/or carbon. This subfamily also includes the Bacillus subtilis Na+/proline cotransporter (OpuE) which has an osmoprotective instead of catabolic role. Expression of the opuE gene is under osmotic control and different sigma factors contribute to its regulation; it is also a putative CcpA-activated gene. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271369 Cd Length: 464 Bit Score: 114.91 E-value: 1.34e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 34 MFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLwISVPFAlshpAVADIG-F 112
Cdd:cd11475 130 TIYAAAQLVAGGKLFESLFGIDYSTGLLIGAVVVVAYTFLGGFLAVSWTDFFQGLLMLLAL-VLVPIV----ALAALGgL 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 113 TAVHAKyqkpwLGTVDSSEVYSWLDSFLLLMLGGIPWQA-----YF------QRVLSSSSATYAQVLSFLAAFGCLVMAI 181
Cdd:cd11475 205 SGLVAA-----LAAIDPGLLSPFGGDLGAGGLLAIISLLawglgYFgqphilVRFMAIRSPKEIKKARRIAMVWMILFLL 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 182 PAILIGAIGAstdwnqtAYgLPDPkTTEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQL 261
Cdd:cd11475 280 GAVLVGLLGR-------AL-FPDG-LLGDPETVFPVLAQELFPPWLAGILLAAILAAIMSTADSQLLVCSSALTEDLYKA 350
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 262 SFRQNASDKEIVWVMRITVFVFGASATAMALltktvyglwYLSSDLVYIVIF----------PQLLCVLFVKGTNTYGAV 331
Cdd:cd11475 351 FLRKEASDKELVWVSRLAVLVIALIALLIAL---------NPPSSVFSLVSFawaglgaafgPLLLLSLYWKRTTRQGAL 421
|
....*...
gi 756761759 332 AGYVSGLF 339
Cdd:cd11475 422 AGMIAGAV 429
|
|
| sss |
TIGR00813 |
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ... |
2-337 |
1.35e-26 |
|
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273282 [Multi-domain] Cd Length: 407 Bit Score: 111.24 E-value: 1.35e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 2 RSKGYVTMLDPFQQIYGKR----MGGLLFIPALMGEMfwAAAIFSAlGATISVIIDVDMHISVIISALIATLYTLVGGLY 77
Cdd:TIGR00813 61 INNGAYTMPEYLEKRFGKRilrgLSVLSLILYIFLYM--SVDLFSG-ALLIELITGLDLYLSLLLLGAITILYTVFGGLK 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 78 SVAYTDVVQLFCIFVGLWISVPFALShpavaDIGFT-AVHAKYQKPWLGTVDSSEVY------SWLDSFLLLMLGGIPW- 149
Cdd:TIGR00813 138 AVVWTDTIQAVIMILGTFILPVFAFS-----EVGGLgTFVEKASQAAPTNPSPDDLYdffrdpSTSDLPWGAGVFGLPHv 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 150 -------QAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGAS--TDWNQtaygLPDPKTTEEADMILPIVLQ 220
Cdd:TIGR00813 213 alwywtnQVIVQRCLAAKSAKHAKKGCLISGVLKLLPMFGAVLPGLIARAlyTDIDP----ALAGAVNQNSDQAYPLLVQ 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 221 YLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNAS-DKEIVWVMRITVFVFGASA-TAMALLTKTVY 298
Cdd:TIGR00813 289 ELMPPGLAGLFLAAILAAVMSTLSSQLNSASTVFTMDLYKKIIRPNASgEKKIVMRGRIAVLVAAVIAgFVAAAQGGQVL 368
|
330 340 350
....*....|....*....|....*....|....*....
gi 756761759 299 GLWYLSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSG 337
Cdd:TIGR00813 369 QYVQEAFGGLGAPFLPVFLLGIFWKRMNAKGALAGMIAG 407
|
|
| SLC5sbd_u1 |
cd11477 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
22-358 |
3.58e-24 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271371 Cd Length: 493 Bit Score: 104.97 E-value: 3.58e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 22 GGLLFIPALMGEMFWAAAIFSAlgatisVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFA 101
Cdd:cd11477 125 FALLSNVDILAWVFLAAIKVSA------VFGPWDPWLTILILGLITLIYTVIGGLWAVVVTDVVQFVIAMAASIAVAVLA 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 102 LSHPAvadiGFTAVHAKYQKPWLGTVDSSEVYSWLDSFLLLML---------GGIPWqAYFQRVLSSSSATYA-QVLSFL 171
Cdd:cd11477 199 LNAVG----GPGGLFAQLPEGHLDLFGSGLGASGFYITFFFILffgwyplsySGGGW-YLAQRYLSAKSEKAAkAAAWLF 273
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 172 AAfgcLVMAIPAILIGAIGASTDWNqtaYGLPDPKTTEEAdmILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSAS 251
Cdd:cd11477 274 AA---LYLVRPWPWMLPALAALVLY---PDLDDPEADFEL--AYPMMIKEYLPAGLLGLVLAGLLAATMSTVSTHLNWGA 345
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 252 SMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIVIFPQLLCV---LFVKGTNTY 328
Cdd:cd11477 346 AYLVNDIYKRFIKPNASEKHLLKVGRLATVLFGLLSIVVALASDSIGGAFWIVLALGAGLGGPLILPWlwwRFNAWTEIW 425
|
330 340 350
....*....|....*....|....*....|
gi 756761759 329 GAVAGYVSGLFLRITGGEPYLYLQPLIFYP 358
Cdd:cd11477 426 AMIASIIVGLVVSVLLKVFGLPEDFLFSFL 455
|
|
| SLC5sbd_DUR3 |
cd11476 |
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is ... |
17-390 |
2.58e-23 |
|
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is the yeast plasma membrane urea transporter. Saccharomyces cerevisiae DUR3 also transports polyamine. The polyamine uptake of S. cerevisiae DUR3 is activated upon its phosphorylation by polyamine transport protein kinase 2 (PTK2). S. cerevisiae DUR3 also appears to play a role in regulating the cellular boron concentration. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271370 Cd Length: 493 Bit Score: 102.66 E-value: 2.58e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 17 YGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWI 96
Cdd:cd11476 115 YGTAAHLVFLVFALFTNVIVLAMLLLGGSAVVNALTGMPIVAASFLIPLGVLLYTLFGGLRATFLTDYIHTVIILIILLV 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 97 SVPFALSHpavADIG-FTAVHAKYQKPWLGTVDSSEVYSWLD--------SFLLLMLGG----IPWQAYFQRVLSSSSAT 163
Cdd:cd11476 195 FAFAVYTS---SDIGsPSKVYDLLQEAAPDLPVEGNQGSYLTfkskagliFGIINIVGNfgtvFLDQGYWQRAIAARPSA 271
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 164 YAQVlSFLAafGCLVMAIPAILIGAIGASTdwnqTAYGLPDPKTTEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSA 243
Cdd:cd11476 272 AVKG-YFLG--GLAWFAIPFLLATTLGLAA----LALGLNPTFEEVSAGLVLPYVAAALLGKGGAAAVLVLLFMAVTSTA 344
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 244 DSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALltktvyGLWYLSSDLVYI----------VIF 313
Cdd:cd11476 345 SAELIAVSSIVTYDIYRTYINPNATGKQLLRVSRIAVIGFGLFMGGLAV------GLNYIGISLGWLllfmgiligsAVF 418
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 756761759 314 PqLLCVLFVKGTNTYGAVAGYVSGLflrITGgepylylqpLIFYPGYYPDDNGIYNQKFPFKTLAMVTSFLTNICIS 390
Cdd:cd11476 419 P-VALGLYWRRQTGTAAVVSPIAGL---VAG---------LAVWLVTAKSYYGEVNVDTTGGNYPMLAGNLVALFSP 482
|
|
| SLC5sbd_SGLT1-like |
cd10329 |
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily ... |
5-392 |
7.87e-21 |
|
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily includes the solute-binding domain of SGLT proteins that cotransport Na+ with various solutes. Its members include: the human glucose (SGLT1, -2, -4, -5 ), chiro-inositol (SGLT5), and myo-inositol (SMIT) cotransporters. It also includes human SGLT3 which has been characterized as a glucose sensor and not a transporter. It belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271363 Cd Length: 538 Bit Score: 95.33 E-value: 7.87e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 5 GYVTMLDPFQQIYGKRMGGLLFIPALMGEMF-WAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTD 83
Cdd:cd10329 95 GVSTMPEFLEKRFGGRSRVYLSVLSLILYVFtKISVDLYAGALVIKQLLGWDLYLSIIVLLVITAIYTIAGGLKAVIYTD 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 84 VVQLFCIFVGLWISVPFALSHpavADIGFTAVHAKY-QKPWLGTV--DSSEVYSWLDSFLLLMLGGIpW-----QAYFQR 155
Cdd:cd10329 175 TLQAVILIIGSAILMFLAFNE---VGGGWSAYMAAIpSGTAFHLFrpPDDPDLPWPGLLLGYPILGI-WywctdQVIVQR 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 156 VLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAYGLPDPKTTEEADMILPIVLQYLCPVYISFFGLGAV 235
Cdd:cd10329 251 VLAAKNLKHARRGALFAGYLKLLPLFLMVLPGMIARALFPDLVACVVPCGNGVGCSDIAYPTLVTELLPVGLRGLVLAVL 330
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 236 SAAVMSSADSSILSASSMFARNIYQLsFRQNASDKEIVWVMRI-TVFVFGASATAMALLTKTVYGLW-YLSSDLVYIVif 313
Cdd:cd10329 331 LAALMSSLTSIFNSASTLFTMDIYKR-LRPEASEKELVRVGRIaTLVVVVISILWAPIIQAQGGSLFnYIQSVLSYLA-- 407
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 314 PQLLCV----LFVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQPLIFYPGYYPDDNGIYnqkfpFKTLAMVTSFLTNICI 389
Cdd:cd10329 408 PPIAAVfllgIFWKRTNEQGAFWGLIAGLVLGLVRLILEFAYGEPDTRPAIIGGIHFLY-----FAFLLFVVSVIVTVIV 482
|
...
gi 756761759 390 SYL 392
Cdd:cd10329 483 SLL 485
|
|
| SSF |
pfam00474 |
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ... |
2-337 |
2.81e-20 |
|
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.
Pssm-ID: 109527 [Multi-domain] Cd Length: 406 Bit Score: 92.40 E-value: 2.81e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 2 RSKGYVTMLDPFQQIYGKR--------MGGLLFIPALMGEMFWAAAIFsalgatISVIIDVDMHISVIISALIATLYTLV 73
Cdd:pfam00474 64 RNLGAYTMPDYLRKRFGGKrilvylsaLSLLLYFFTYMSVQIVGGARL------IELALGLNYYTAVLLLGALTAIYTFF 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 74 GGLYSVAYTDVVQLFCIFVGLWISVPFALSHPAvadiGFTAVHAKYQKPWLGTVDSSEVYSW--------LDSF-LLLML 144
Cdd:pfam00474 138 GGFLAVSWTDTIQAVLMLFGTIILMIIVFHEVG----GYSSAVEKYMTADPNGVDLYTPDGLhilrdpltGLSLwPGLVL 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 145 GGIPWQAYFQRVLSSSSATYAqVLSFLAAFGCLVMaipaILIGAIGASTDWNQTAYGLPDPKTTE--EADMILPIVLQYL 222
Cdd:pfam00474 214 GTTGLPHILQRCLAAKDAKCI-RCGVLILTPMFII----VMPGMISRGLFAIALAGANPRACGTVvgCSNIAYPTLAVKL 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 223 CPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQN-ASDKEIVWVMRITVFVFGASATAMALLTKTVYGLW 301
Cdd:pfam00474 289 GPPGLAGIMLAVMLAAIMSTLTSQLLSSSSAFTHDLYKNIRRKAsATEKELVGRSRIIVLVVISLAILLAVQPAQMGIAF 368
|
330 340 350
....*....|....*....|....*....|....*...
gi 756761759 302 YLSSDLVYI--VIFPQLLCVLFVKGTNTYGAVAGYVSG 337
Cdd:pfam00474 369 LVQLAFAGLgsAFLPVILLAIFWKRVNEQGALWGMIIG 406
|
|
| SLC5sbd_u3 |
cd11479 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
43-337 |
2.35e-19 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271373 Cd Length: 454 Bit Score: 90.36 E-value: 2.35e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 43 ALGATISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLW-ISVPFALSHPAvadiGFTAVHAKYQK 121
Cdd:cd11479 134 AIGTVFSVLFGLPRTLSILVGGGIVVLYSVLGGMWSITLTDIIQFVIKTIGIFlLLLPLALSKAG----GLSGLQEKLPA 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 122 PW--LGTVDSSEVYSWldsFLLLMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTdwnqta 199
Cdd:cd11479 210 SYfdLTSIGWDTIVTY---FLLYFFGILIGQDIWQRVFTARSEKVARWGGVAAGLYCVLYGVAGALIGMAAAVL------ 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 200 ygLPDPKTTEEAdmiLPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRIT 279
Cdd:cd11479 281 --LPDLANPQNA---FATMAQEVLPVGLRGLVLAAALAAMMSTASGALLASSTVLTNDVLPRLRRKNESERSEVRLSRLF 355
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 756761759 280 VFVFGASATAMALLTKTVYGLWYLSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSG 337
Cdd:cd11479 356 TLLLGVVVIVIAVLVNDVVAALTIAYAILVGGLLVPILGGLFWKRATGAGALASMVAG 413
|
|
| SLC5sbd_NIS-like_u2 |
cd11494 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
32-358 |
3.34e-19 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters, SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271385 [Multi-domain] Cd Length: 473 Bit Score: 89.97 E-value: 3.34e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 32 GEMFWAAAIFsalgatISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALSHPAVAdiG 111
Cdd:cd11494 129 GVTIYAPAII------LSTILGWSLWLTILLIGGITIIYTVLGGIKAVIWTDVIQMVIIWAGLFIAFGLLLKLLPVG--F 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 112 FTAVHAKYQKPWLGTVDSSevYSWLDSFLLL--MLGGI-PWQAYF-------QRVLSSSSATYAQVLSFLAAFGCLVMAI 181
Cdd:cd11494 201 VDALLVAGKSGRLNALDFS--FDLSDTYTFWsgLIGGFfLYLSYFgtdqsqvQRYLTAKSIKEARKSLLLNGFLKFPMQF 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 182 PAILIGAI--------GASTDWNQTAYGLPDPKtteeaDMILPIVLQYLCPVYISFFgLGAVSAAVMSSADSSILSASSM 253
Cdd:cd11494 279 FILLIGVLvfvfyqfnPFPVSFNPAEDETKDTN-----YIFLRFVLNYLPPGVIGLL-IAAIFAAAMSSIDSALNSLATV 352
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 254 FARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMAL---LTKTVYGLWYLSSDLVYIVIFPQLLCVLFVKGTNTYGA 330
Cdd:cd11494 353 TVIDIYRRFFKKDASDEHYLKVSRLLTVFWGLLAIVFALfagLAGSLIEAVNKLGSLFYGPILGVFLLAFFTKKANGKGV 432
|
330 340
....*....|....*....|....*...
gi 756761759 331 VAGYVSGLFLRItggepYLYLQPLIFYP 358
Cdd:cd11494 433 FAGAILGVIVVI-----VLWLFPDVSWL 455
|
|
| SLC5sbd_u2 |
cd11478 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
32-394 |
5.37e-19 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271372 Cd Length: 496 Bit Score: 89.27 E-value: 5.37e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 32 GEMFWAAAIFsalgatISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALSHPA----- 106
Cdd:cd11478 130 GINLYALALV------LNVLLGWPLWLSIILSAAIVLAYTTLGGLTSAIYNEVLQFFLIVAGLIPLVIIGLIKVGgwdgl 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 107 VADIGFTAVHAKYQKPWLGTVDSSEVYSWLDSFLLLMLGGIPWQAYF-------QRVLSSSSATYAQVLSFLAAFgcLVM 179
Cdd:cd11478 204 SEKIDANGPPGWNGLSWGPQGSQSTNPMGVNLGLVFGLGFVLSFGYWttnflevQRAMAAKDLSAARRTPLIAAF--PKM 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 180 AIPAILI--GAIGASTDWNQTAYGLPDPktteeaDMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARN 257
Cdd:cd11478 282 FIPFLVIlpGLIALVLVPELGASGGLDY------NQALPYLMAKYLPPGLLGLGITALLAAFMSGMAGNVSAFNTVFTYD 355
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 258 IYQLSFRQNASDKEIVWVMRITVFVfgasATAMALLTKtvyglwYLSSDLVYIVIFPQLLCVLFV-------------KG 324
Cdd:cd11478 356 IYQTYIVKDAPDKHYLKVGRIATVV----GVLISIGTA------YIASSFNNIMDYLQLLFSFFNaplfatfllgmfwKR 425
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 325 TNTYGAVAGYVSGlflriTGGEPYLYlqplIFYPGYYPDDNGIYNQKFPFKTLAMVTSFLTNICISYLAK 394
Cdd:cd11478 426 ATPWGGFWGLLAG-----TASAIVLY----GLYELGLIVYHSDMAPNFYGAWWAFVVCFVVTVLVSLLTK 486
|
|
| SLC5sbd_vSGLT |
cd10325 |
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute ... |
4-340 |
4.16e-18 |
|
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; vSGLT transports D-galactose, D-glucose, and alpha-D-fucose, with a sugar specificity in the order of D-galactose >D-fucose >D-glucose. It transports one Na+ ion for each sugar molecule, and appears to function as a monomer. vSGLT has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271360 Cd Length: 523 Bit Score: 86.98 E-value: 4.16e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 4 KGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGA-TISVIIDVDMHISVIISALIATLYTLVGGLYSVAYT 82
Cdd:cd10325 96 NGIYTMPQFLEERYDGRVRTIMAVFWLLLYVFVNLTSVLYLGAlAIETITGIPLTYSIIGLALFAAAYSIYGGLKAVAWT 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 83 DVVQLFCIFVGLWISVPFALSHPAVADIGFTAVHAKYQKPW------LGTVDSSEVYSWLDSfLLLMLGGIpWQAYF--- 153
Cdd:cd10325 176 DVIQVVFLVLGGLVTTYIALSLLGGGEGVFAGFTLLAAEAPehfhmiLDKSNPEDAYKDLPG-IAVLLGGL-WVANLsyw 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 154 -------QRVLSSSSATYAQVLSFLAAFGCLVM----AIPAILIGAIGASTDwnqtaygLPDPKTTEEADMILPIVLQYL 222
Cdd:cd10325 254 gfnqyiiQRALAAKSLSEAQKGIVFAAFLKLLIpfivVIPGIAAYVLASNLL-------LPAATGIEKPDQAYPWLLRNL 326
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 223 cPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLtktvygLWY 302
Cdd:cd10325 327 -PTGLKGLVFAALTAAIVSSLASMLNSISTIFTMDIYKKYIPKKASEKQLVNVGRLAAVIALIIAALIAPP------LLG 399
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 756761759 303 LSSDLVYI-----VIFPQLLCV----LFVKGTNTYGAVAGYVSGLFL 340
Cdd:cd10325 400 LDQAFQYIqeytgFISPGILAIfllgLFWKRATSAGALVAAILSIVL 446
|
|
| SLC5sbd_NIS-like_u3 |
cd11495 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
20-338 |
3.90e-16 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271386 [Multi-domain] Cd Length: 473 Bit Score: 80.66 E-value: 3.90e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 20 RMGGLLFIPALMgemfwaaaifsalgatISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQ--------LFCIF 91
Cdd:cd11495 130 RMGIVLYLPALA----------------LSAVTGINPYIIIILMGVLCIIYTVLGGIEAVIWTDVIQgvvllggaLLCLI 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 92 VGLWiSVPFALSHpaVADIGFTAvhakyQKPWLGTVDSSEVYSwldSFLLLMLGGIPW--------QAYFQRVLSSSSAT 163
Cdd:cd11495 194 ILLF-SIPGGFGE--VFDIAIAN-----GKFSLGDFSFSLTES---TIWVIFIGGIFNnlqsytsdQDVVQRYLTTKSIK 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 164 YAQVLSFLAAfgclVMAIPAILI-GAIGAS--TDWNQTAyglPDPKTTEEADMILP-IVLQYLcPVYISFFGLGAVSAAV 239
Cdd:cd11495 263 EAKKSLWTNA----LLALPVALLfFGIGTAlyVFYQQHP---ELLPAGINGDAVFPyFIVTQL-PVGVAGLIIAAIFAAA 334
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 240 MSSADSSILSASSMFARNIYQlSFRQNASDKEIVWVMRITVFVFGASATAMALL-----TKTVYGLWYLSSDLVYIVIFP 314
Cdd:cd11495 335 MSTISSSLNSVATCITTDFYK-RLSPDPSDKQYLKVARLITLLVGLLGTLVALYlanagVKSLLDAFNTLTGLFGGGLAG 413
|
330 340
....*....|....*....|....
gi 756761759 315 QLLCVLFVKGTNTYGAVAGYVSGL 338
Cdd:cd11495 414 LFLLGIFTKRANAKGALVGIIVSI 437
|
|
| SLC5sbd_u4 |
cd11480 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
34-392 |
1.75e-15 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271374 Cd Length: 488 Bit Score: 78.70 E-value: 1.75e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 34 MFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGL------------WISVPFA 101
Cdd:cd11480 124 FFYLVAQMVGAGLLLSLLLGIPYEVGVVVVGALMIVYVVLGGMRATTWVQIIQYVLLLGAFlvpailvlarfgGNPLGAG 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 102 LSHPAVADIGFTAVHAKYQKPWLGTVDSSEVYSWLdsfLLLMLG--GIPwqAYFQRVLSSSSATYAQVLSFLAAFGCLVM 179
Cdd:cd11480 204 PGLLGLAAAAASGAGEAYLAPGLLLTDPLDVISLT---LALMLGtaGLP--HVLMRFYTVPDARAARKSVVWALGFIGLF 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 180 AIPAILIGAIGASTDWNQTAYGLPDPKTTEEADMILPIVLQYLCPVYIsFFGL---GAVsAAVMSSADSSILSASSMFAR 256
Cdd:cd11480 279 YLLAPALGFGARALVGPDVIGAPIAGELDGGGDMAVLLLPEIAGLGDL-LLALvaaGAF-AAILATVAGLLLAAASALAH 356
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 257 NIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTvyglwylsSDLVYIV----------IFPQLLCVLFVKGTN 326
Cdd:cd11480 357 DLYAGVIRPGASERREVRVARIAAVVVGVIAILLALLFPP--------QNVAFLValafaiaasaFFPVLVLGIFWRRFT 428
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 756761759 327 TYGAVAGYVSGLFLRITggepYLYLQPLIFYPGYYPDDNGiynqkFPFKTLAMVT---SFLTNICISYL 392
Cdd:cd11480 429 TRGAIAGMLVGLLVSLV----LIVLSPAVSGAPPGHDFAG-----FPLTNPGLVSvplGFLVAIVVSLL 488
|
|
| ActP |
COG4147 |
Na+(or H+)/acetate symporter ActP [Energy production and conversion]; |
45-394 |
4.68e-15 |
|
Na+(or H+)/acetate symporter ActP [Energy production and conversion];
Pssm-ID: 443318 Cd Length: 526 Bit Score: 77.51 E-value: 4.68e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 45 GATISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQ----LFCIFVG-LWISVPFALSHPAVAD--IGFTAVHA 117
Cdd:COG4147 149 GVLISLLLGVDYEVAVVIVGVLMIVYVVLGGMKGTTWVQIIKavllIFAYTVPaVLVLAQFGFNPLPLLAkaAEVHDLGA 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 118 KYQKPWLGtvdsseVYSWLDSFLL---LMLG--GIPW---------QAYFQRvlssSSATYAQVLSFLAAFGCLVMAIPA 183
Cdd:COG4147 229 AYLEPGGL------VKSPLDFISLglaLMLGtaGLPHilmrfftvpDAKEAR----KSVGWALGFIGLFYLTAPALGFGA 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 184 ILIgaIGASTDWNQTAYGLPDPKTTEEADMILPIVLQyLCPVYISFFGLGAVsAAVMSSADSSILSASSMFARNIYQLSF 263
Cdd:COG4147 299 RAL--VGPLPEWFDTGLIGAADGGGNMAVLALAEIAG-GGNWLLGLVAAGAF-ATILAVVAGLLLAIASAISHDLYANVI 374
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 264 RQNASDKEIVWVMRITVFVFGASATAMALLTKT--VYGLWYLSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSGLFLR 341
Cdd:COG4147 375 KGKATEKEELRVARIAAVVIGVVAILLGINAPPqnVAFLVALAFALAASANFPVLLLSIFWKRFNTRGAVAGMLVGLISA 454
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 756761759 342 ITggepYLYLQPLIFYPGYypdDNGIynqkFPFK---TLAMVTSFLTNICISYLAK 394
Cdd:COG4147 455 LV----LIVLSPFVWVLGV---DAAL----FPLEnpgLVSMPLGFLVAIVVSLLTP 499
|
|
| PanF |
COG4145 |
Na+/panthothenate symporter [Coenzyme transport and metabolism]; |
2-338 |
1.40e-14 |
|
Na+/panthothenate symporter [Coenzyme transport and metabolism];
Pssm-ID: 443316 Cd Length: 484 Bit Score: 75.65 E-value: 1.40e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 2 RSKGYVTMLDPFQQIYGKR----MGGLLFIPALMGEMfwaAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGGLY 77
Cdd:COG4145 104 RKYNAVTLADWLRARYQSKalvlLAALLLLLFFIAFM---VAQFVGGARLLETVTGISYTTGLLIFGVTVVLYTTIGGFR 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 78 SVAYTDVVQLFCIFVGLWISVPFALshpaVADIGFTAV--HAKYQKPWLGT---VDSSEVYSWLDSF-LLLMLGGIPWQA 151
Cdd:COG4145 181 AVVLTDAIQGIIMLVGTVLLLIGVI----SAGGGIENImsTLAAIDPNLVSptgPDGFLPRPFVISFwILVGFGVIGLPH 256
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 152 YFQRVLSS-SSATYAQVLsFLAAFGCLVMAIPAILIGAIGASTdwnqtaygLPDpktTEEADMILPIVLQYLCPVYISFF 230
Cdd:COG4145 257 TAVRCMAYkDSKSLHRAM-IIGTIVVGLLMFGMHLIGVLGRAV--------LPD---LTVPDQVIPTLMVKVLPPFLAGI 324
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 231 GLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNAS--DKEIVWVMRITVFVFGASATAMALLTKTVygLWYLSSDLV 308
Cdd:COG4145 325 FLAGPLAAIMSTVDSLLLQASSTIVKDLYLNYINPKASenEKKLKRLSKLVTLVLGLIVFLLALNPPDL--IIWLNLFAF 402
|
330 340 350
....*....|....*....|....*....|...
gi 756761759 309 Y---IVIFPQLLCVLFVKGTNTYGAVAGYVSGL 338
Cdd:COG4145 403 GgleAAFFWPLVLGLYWKRANATGAIASMLVGV 435
|
|
| SLC5sbd_NIS-like |
cd10326 |
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ... |
20-355 |
3.91e-13 |
|
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and 2. SMCT1(the product of the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (product of the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271361 [Multi-domain] Cd Length: 472 Bit Score: 71.05 E-value: 3.91e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 20 RMGGLLFIPALMGEMFwaaaIFSALGATISVIidvdmhisVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVP 99
Cdd:cd10326 126 GAGIRLYLVALVLQQF----LFDSLGIPFWLT--------VLITGLLIWLYTFRGGIKTVVWTDTLQTVFLLVGLVLTII 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 100 FALSHpavADIGF-TAVHAKYQKPWLGTVDSSEVYSWLdSFLLLMLGGIPW--------QAYFQRVLSSSSATYAQVLSF 170
Cdd:cd10326 194 IISNS---LGLGFgEAISAAGESGYSRIFNFDDDNSRR-TFWKQFLGGIFItiamtgldQDMMQRNLSCKNLKDAQKNML 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 171 LAAFGCLVMaipAILIGAIGASTDWNQTAYGLPDPKttEEADMILP-IVLQYLCPVYISFFGLGAVSAAvMSSADSSILS 249
Cdd:cd10326 270 TFGVILVPV---NLLFLLLGVLLYTYAQKNGIALPA--KDSDQLFPyFALNGLPPGVSGLFVAGIIAAA-MSSADSALTA 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 250 ASSMFARNIYQLSFRQN--ASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIVIFPQLLCVLFVKGTNT 327
Cdd:cd10326 344 LTTSFCVDILNRFKRKSekKSERKYVHIAFSLTFVLGILVFGSASNSGSLIDAIFKVAGYTYGPLLGLFAFGLFTKRAVK 423
|
330 340 350
....*....|....*....|....*....|....*..
gi 756761759 328 --YGAVAG-------YVSGLFLRITGGEPYLYLQPLI 355
Cdd:cd10326 424 dkWVPLVGllapvlsYLLVSNSEGFFGYKFGFELLII 460
|
|
| SLC5sbd_SGLT1 |
cd11486 |
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a ... |
5-342 |
1.03e-11 |
|
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a high-affinity/low-capacity glucose transporter, which can also transport galactose. In the transport mechanism, two Na+ ions first bind to the extracellular side of the transporter and induce a conformational change in the glucose binding site. This results in an increased affinity for glucose. A second conformational change in the transporter follows, bringing the Na+ and glucose binding sites to the inner surface of the membrane. Glucose is then released, followed by the Na+ ions. In the process, hSGLT1 is also able to transport water and urea and may be a major pathway for transport of these across the intestinal brush-border membrane. hSGLT1 is encoded by the SLC5A1 gene and expressed mostly in the intestine, but also in the trachea, kidney, heart, brain, testis, and prostate. The WHO/UNICEF oral rehydration solution (ORS) for the treatment of secretory diarrhea contains salt and glucose. The glucose, along with sodium ions, is transported by hSGLT1 and water is either co-transported along with these or follows by osmosis. Mutations in SGLT1 are associated with intestinal glucose galactose malabsorption (GGM). Up-regulation of intestinal SGLT1 may protect against enteric infections. SGLT1 is expressed in colorectal, head and neck, and prostate tumors. Epidermal growth factor receptor (EGFR) functions in cell survival by stabilizing SGLT1, and thereby maintaining intracellular glucose levels. SGLT1 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5)transporter family.
Pssm-ID: 271379 Cd Length: 636 Bit Score: 67.27 E-value: 1.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 5 GYVTMLDPFQQIYG-KRMGGLLFIPALMGEMFW--AAAIFSalGAT-ISVIIDVDMHISVIISALIATLYTLVGGLYSVA 80
Cdd:cd11486 98 GVVTMPEYLRKRFGgQRIQVYLSVLSLCLYIFTkiSADIFS--GAIfINLALGLNLYLAIVILLAITALYTITGGLAAVI 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 81 YTDVVQLFCIFVGLWISVPFALSHPAvadiGFTAVHAKYQK--PWLGTVDSSEVYSWL-----DSFLLL---MLGGIPW- 149
Cdd:cd11486 176 YTDTLQTIIMVVGSFILMGFAFNEVG----GYDAFMEKYMTaiPSVIGTGNSTSQEKCytpraDSFHIFrdpITGDLPWp 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 150 -----------------QAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAYGLPDP------K 206
Cdd:cd11486 252 gllfglsiltlwywctdQVIVQRCLSAKNMSHVKAGCILCGYLKLLPMFIMVMPGMISRILYTDEIACVVPDEckavcgT 331
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 207 TTEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQlSFRQNASDKEIVWVMRITVFVFGAS 286
Cdd:cd11486 332 EVGCTNIAYPKLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYT-KVRKKASEKELMIAGRLFMLVLIGI 410
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 756761759 287 ATAMALLTKTVYG---LWYLSSDLVYIV--IFPQLLCVLFVKGTNTYGAVAGYVSGLFLRI 342
Cdd:cd11486 411 SIAWVPIVQSAQSgqlFDYIQSITSYLGppIAAVFLLAIFCKRVNEPGAFWGLCVGLLVGL 471
|
|
| SLC5sbd_SGLT2 |
cd11487 |
Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 ... |
3-340 |
1.92e-11 |
|
Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 (hSGLT2) is a high-capacity, low-affinity glucose transporter, that plays an important role in renal glucose reabsorption. It is encoded by the SLC5A2 gene and expressed almost exclusively in renal proximal tubule cells. Mutations in hSGLT2 cause Familial Renal Glucosuria (FRG), a rare autosomal defect in glucose transport. hSGLT2 is a major drug target for regulating blood glucose levels in diabetes. hSGLT2 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212056 [Multi-domain] Cd Length: 583 Bit Score: 66.10 E-value: 1.92e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 3 SKGYVTMLDPFQQIYG-KRMGGLLFIPALMGEMFWAAAIFSALGAT-ISVIIDVDMHISVIISALIATLYTLVGGLYSVA 80
Cdd:cd11487 96 TAGVITMPQYLKKRFGgQRIRLYLSVLSLFLYIFTKISVDMFSGAVfIQQALGWNIYASVIALLGITMIYTVTGGLAALM 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 81 YTDVVQLFCIFVGLWISVPFALSHPAvadiGFTAVHAKYQK----------PWLGTVDSSEVYSWLDSFLLL---MLGGI 147
Cdd:cd11487 176 YTDTVQTFVIIGGACVLMGYAFHEVG----GYSALFEKYLKavpsltvsedPAVGNISSSCYRPRPDSYHLLrdpVTGDL 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 148 PW------------------QAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAYGLPDPKT-- 207
Cdd:cd11487 252 PWpalilgltivsswywcsdQVIVQRCLAARSLTHVKAGCILCGYLKLLPMFLMVMPGMISRVLYPDEVACVEPSVCLrv 331
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 208 --TEE--ADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQlSFRQNASDKEIVWVMRI-TVFV 282
Cdd:cd11487 332 cgTEVgcSNIAYPKLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIWT-RLRPQAGDKELLLVGRVwVVCI 410
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 756761759 283 FGASATAMALLTKTVYGLWYLSSDLVYIVIFPQLLCV----LFVKGTNTYGAVAGYVSGLFL 340
Cdd:cd11487 411 VAVSVAWIPVVQAAQGGQLFDYIQSVSSYLAPPIAAVfflaLFVKRVNEPGAFWGLIGGLLM 472
|
|
| SLC5sbd_SGLT4 |
cd11488 |
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 ... |
15-343 |
5.85e-11 |
|
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 (hSGLT4) has been reported to be a low-affinity glucose transporter with unusual sugar selectivity: it transports D-mannose but not galactose or 3-O-methyl-D-glucoside. It is encoded by the SLC5A9 gene and is expressed in intestine, kidney, liver, brain, lung, trachea, uterus, and pancreas. hSLGT4 is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5 )transporter family.
Pssm-ID: 271380 Cd Length: 605 Bit Score: 64.57 E-value: 5.85e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 15 QIYGKRMGGLLFIPALMGEMFWAAAIFsalgatISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGl 94
Cdd:cd11488 115 RIYMSVLSLILYIFTKISTDIFSGALF------IQVSLGWNLYLSTVILLAVTALYTIAGGLTAVIYTDALQTVIMVIG- 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 95 wisvPFALSHPAVADIG-FTAVHAKYQK--PWLGTVDSSEVYSWLDSFLLL---MLGGIPW------------------Q 150
Cdd:cd11488 188 ----AFVLMFIAFDKVGwYPGLEQQYEKaiPALTVPNTTCHLPRSDAFHIFrdpVTGDIPWpglifgltvlatwvwctdQ 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 151 AYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTayGLPDPKTTEE--------ADMILPIVLQYL 222
Cdd:cd11488 264 VIVQRSLSAKNLSHAKGGSVLGGYLKILPMFFVVMPGMISRALFPDEV--GCVDPDECQKicgakvgcSNIAYPKLVVEL 341
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 223 CPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQlSFRQNASDKEIVWVMRI-TVFVFGASATAMALLTKTVYGLW 301
Cdd:cd11488 342 MPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTMDVWQ-RIRRRASEQELMVVGRVfILLLVVISILWIPIIQTANSGQL 420
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 756761759 302 --YLSSDLVYIV--IFPQLLCVLFVKGTNTYGAVAGYVSGLFLRIT 343
Cdd:cd11488 421 fdYIQAVTSYLSppITAVFILAIFWKRVNEPGAFWGLMVGLVVGLV 466
|
|
| SLC5sbd_PanF |
cd10327 |
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute ... |
7-338 |
8.49e-11 |
|
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; PanF catalyzes the Na+-coupled uptake of extracellular pantothenate for coenzyme A biosynthesis in cells. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212037 Cd Length: 472 Bit Score: 63.76 E-value: 8.49e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 7 VTMLDPFQQIYGKRmgGLLFIPALMGEMFWAAAIFSAL--GAT-ISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTD 83
Cdd:cd10327 106 VTIIDYLRARYNSK--ALVVLSSLALIVFFIAAMVAQFigGARlLEAVTGLSYVTGLLIFGLTVILYTTIGGFRAVALTD 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 84 VVQLFCIFVG---LWISVPFALSHPAVADIGFTAVHAKYQKPWLGTVDSSevySWLDSF-LLLMLG--GIPWQAyfQRVL 157
Cdd:cd10327 184 AIQGIVMIIGtvlLLVGVLAAGGGMEAIMATLAEIDPNLLTPFGPGFLSP---PYILSFwVLVGFGviGLPQTA--VRCM 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 158 S---SSSATYAQVLSflaAFGCLVMAIPAILIGAIGASTdwnqtaygLPDPkttEEADMILPIVLQYLCPVYISFFGLGA 234
Cdd:cd10327 259 GykdSKSMHRAMIIG---TVVVGFLMLGMHLAGVLGRAV--------LPDL---EVPDKVIPTLALKVLPPWLAGLFLAG 324
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 235 VSAAVMSSADSSILSASSMFARNIYQLSFR--QNASDKEIVWVMRITVFVFGASATAMALLTKTVyglwylssdLVYIVI 312
Cdd:cd10327 325 PLAAIMSTVDSQLILASSAIVKDLYLNYKNkeKKTSEKKVKRISLIITIILGLLVFLLAINPPDL---------IVWLNL 395
|
330 340 350
....*....|....*....|....*....|....*.
gi 756761759 313 FP----------QLLCVLFVKGTNTYGAVAGYVSGL 338
Cdd:cd10327 396 FAfggleaaffwPLVLGLYWKRANATGALASMVVGL 431
|
|
| SLC5sbd_SGLT6 |
cd11490 |
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human ... |
36-426 |
3.76e-10 |
|
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human SGLT6 (also called KST1, SMIT2) is a chiro-inositol transporter, which also transports myo-inositol. It is encoded by the SLC5A11 gene. Xenopus Na1-glucose cotransporter type 1 (SGLT-1)-like protein is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271381 Cd Length: 602 Bit Score: 62.23 E-value: 3.76e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 36 WAAAIFsalgatISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALSHPAvadiGFTAV 115
Cdd:cd11490 136 YAGAVF------IQQALQWDLYLAVVGLLGITALYTVAGGLAAVIYTDALQTIIMVIGALILMGYSFAEVG----GFEAL 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 116 HAKYQK--PWLGTVDSSEVYSWLDSFLLL---MLGGIPW------------------QAYFQRVLSSSSATYAQVLSFLA 172
Cdd:cd11490 206 LEKYFQaiPSIRSPNSTCGIPREDAFHIFrdpVTSDLPWpgvllgmsipslwywctdQVIVQRSLAAKNLSHAKGGSLLA 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 173 AFGCLVMAIPAILIGAIGASTDWNQTAYGlpDPKTTEE--------ADMILPIVLQYLCPVYISFFGLGAVSAAVMSSAD 244
Cdd:cd11490 286 AYLKVLPLFMMVIPGMISRILFPDQVACA--DPEVCKEicgnpsgcSDIAYPKLVMELLPTGLRGLMMAVMLAALMSSLT 363
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 245 SSILSASSMFARNIYQlSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYG---LWYLSSDLVYI-----VIFpql 316
Cdd:cd11490 364 SIFNSASTIFTMDLWR-HIRPRASEWELMIVGRVFVLVLVVVSILWIPLVQASQGgqlFIYIQSISSYLqppvaVVF--- 439
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 317 LCVLFVKGTNTYGAVAGYVSGLFLRITGGE-PYLYLQPLIfypgYYPDDNGIYNQKFPFKTLAMVTSFLTNICISYLAKY 395
Cdd:cd11490 440 IAGCFWKRTNEKGAFWGLMVGLAVGLTRMVlDFIYVTPQC----DQPDTRPDIVKYVHYLYFSMILTILTLVVVVCVSLA 515
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 756761759 396 lfesgTLPPKLDV---------FDAVVarhSEENMDKTIL 426
Cdd:cd11490 516 -----TEPPSKEMisrltwftrFDAVV---ESEELKKAIL 547
|
|
| SLC5sbd_SGLT5 |
cd11489 |
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is ... |
3-343 |
8.38e-10 |
|
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is a glucose transporter, which also transports galactose. It is encoded by the SLC5A10 gene, and is exclusively expressed in the renal cortex. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212058 Cd Length: 604 Bit Score: 61.11 E-value: 8.38e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 3 SKGYVTMLDPFQQIYG-KRMGGLLFIPALMGEMFWAAAIFSALGAT-ISVIIDVDMHISVIISALIATLYTLVGGLYSVA 80
Cdd:cd11489 98 SSGIVTMPEYLQRRFGgERIRMYLSVLSLLLSVFTKISTDLYSGALfVQVCLGWNLYLSTVLMLVVTALYTIAGGLAAVI 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 81 YTDVVQLFCIFVGLWIsvpfaLSHPAVADIGFtavHAKYQKPWLGTVDSSEV---------YSWLDSFLLLMLGGIPW-- 149
Cdd:cd11489 178 YTDALQTLIMVIGAVI-----LTIKAFNQIGG---YSNLEEAYLQAVPSKIIpnttchlprADAMHLFRDPVTGDLPWtg 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 150 ----------------QAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIgaSTDWNQTAYGLPDPKTTEEA-- 211
Cdd:cd11489 250 mtfgltimatwywctdQVIVQRSLSARSLSHAKGGSILASYLKMLPMGLIIMPGMI--SRALFPDDVACVDPEECLRVcg 327
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 212 ------DMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQlSFRQNASDKEIVWVMRI-TVFVFG 284
Cdd:cd11489 328 aevgcsNIAYPKLVMELMPSGLRGLMIAVMMAALMSSLTSIFNSSSTLFTMDIWR-RLRPGASERELLLVGRLvTVILVG 406
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 756761759 285 ASATAMALLTKTVYGLWYLSSDLVYIVIFPQLLCV----LFVKGTNTYGAVAGYVSGLFLRIT 343
Cdd:cd11489 407 VSVVWIPILQSSNSGQLYIYIQSVTSYLAPPVTAVfvlaVFWRRANEQGAFWGLMAGLVVGLT 469
|
|
| SLC5sbd_NIS-like_u1 |
cd11493 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
48-293 |
4.58e-09 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271384 [Multi-domain] Cd Length: 479 Bit Score: 58.38 E-value: 4.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 48 ISVIIDVD-----MHISVIISALIATLYTLVGGLYSVAYTDVVQlFCIFVGLWISVPFALSHPAVADIGFTAVHAkyQKP 122
Cdd:cd11493 138 VSMILGADgvalsYIASILIISVVTLLYTYFGGIRAVVWTDVIQ-LVVYIGGAVAALAYLLGALPADWLQIAAAA--GKF 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 123 WLGTVDS-----SEVYSwldsFLLLMLGGIPW--------QAYFQRVLSSSSATYAQvlsfLAAFGCLVMAIP-AILIGA 188
Cdd:cd11493 215 HLFDLSDlilglTSPYT----FWAAIIGGALLsmashgtdQLMVQRLLACRNLRDAQ----KALIGSGVVVFPqFALFLL 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 189 IGASTdWnqTAYGLPDP--KTTEEADMILP-IVLQYLcPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQ 265
Cdd:cd11493 287 IGLLL-Y--VYYGGASLaaLGLGSPDEVFPyFIVHEL-PAGLRGLLIAGILAAAMSTLSSALNSLASSTVQDLYQPWKRR 362
|
250 260
....*....|....*....|....*...
gi 756761759 266 NASDKEIVWVMRITVFVFGASATAMALL 293
Cdd:cd11493 363 RLSDEKLLRASRLLTLVWAVVLVGIALL 390
|
|
| SLC5sbd_NIS-SMVT |
cd11492 |
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ... |
47-359 |
8.22e-09 |
|
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (encoded by the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (encoded by the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and -2. SMCT1(encoded by the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (encoded by the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271383 [Multi-domain] Cd Length: 522 Bit Score: 57.88 E-value: 8.22e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 47 TISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALSHPavadIGFTAVhakyqkpWLGT 126
Cdd:cd11492 141 ALSQVTGINLHIIILVVGIVCIFYTTLGGLKAVVWTDVFQVVVMFGGVLAVIILGTIDV----GGFSEV-------WEIA 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 127 VDSSEVYSW---LD-----SFLLLMLGG-IPW-------QAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIG 190
Cdd:cd11492 210 EEGGRLEFFnfdPDptvrhTFWSLVIGGtFTWlslygvnQTQVQRYLSLPSLKSAKKALWLNIVGLILILSLCCFTGLVI 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 191 ASTDWNqtayglPDPKTT---EEADMILPIVLQYLCPVYISFFGL---GAVSAAvMSSADSSILSASSMFARNIYQLSFR 264
Cdd:cd11492 290 YAKYHD------CDPLTAgliKKPDQLLPYFVMDVLGHLPGLPGLfvaGIFSAA-LSTLSSGLNSLAAVILEDFIKPFFK 362
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 265 QNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIVIFPqLLCV----LFVKGTNTYGAVAGYVSGLF- 339
Cdd:cd11492 363 KKLSERQATNIMKLLVVVFGLLCIGLAFLVEKLGGVLQLSLSIFGITGGP-LLGIftlgMFFPWANSKGALVGLLVGLIf 441
|
330 340
....*....|....*....|.
gi 756761759 340 -LRITGGEPYLYLQPLIFYPG 359
Cdd:cd11492 442 mLWIGIGGQIAIAPGPLSFPP 462
|
|
| SLC5sbd_YidK |
cd10328 |
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; ... |
58-340 |
5.62e-08 |
|
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Uncharacterized subfamily of the solute binding domain of the solute carrier 5 (SLC5) transporter family (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily includes the uncharacterized Escherichia coli YidK protein, and belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271362 Cd Length: 472 Bit Score: 54.85 E-value: 5.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 58 ISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGlWISVPF----ALSHPAVADIGFTAVHAKYQK-PWLGTVDSSEV 132
Cdd:cd10328 157 LLVWLIGIIGAIYAIFGGLKAVAVSDTINGVGLLIG-GLLIPIlgliALGDGSFLAGLDTLLTAHPEKlNAIGGADSPVP 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 133 YSWLdsFLLLMLGGI-PW---QAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIgastdwnqtAYGLPdPKTT 208
Cdd:cd10328 236 FSTL--FTGMLLVNLfYWctnQAIIQRALAAKNLKEGQKGVLLAGFFKLLVPLILVLPGII---------AFHLY-GDGL 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 209 EEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASAT 288
Cdd:cd10328 304 ENADMAYPTLVADVLPKWLSGFFAAVLFGAILSSFNSALNSAATLFSLDIYKPIINKNATDKQLVKVGKIFGIVLALISM 383
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 756761759 289 AMA-LLTKTVYGLWYL---SSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSGLFL 340
Cdd:cd10328 384 IIApFIAYAPEGLFNYlqqFNGFFSIPILAIVLVGFFTKRVPALAAKIALIFGVIL 439
|
|
| PRK10484 |
PRK10484 |
putative transporter; Provisional |
58-344 |
4.23e-07 |
|
putative transporter; Provisional
Pssm-ID: 236699 [Multi-domain] Cd Length: 523 Bit Score: 52.19 E-value: 4.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 58 ISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALShpAVADIGF-------TAVHA-KYQKpwLGTVDS 129
Cdd:PRK10484 163 LLVWLIGIIGAIYAVFGGLKAVAVSDTINGIGLLIGGLLVPVFGLI--ALGDGSFmqgleqlTTVHPeKLNS--IGGATD 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 130 SevYSWLDSFLLLMLGGI-PW---QAYFQRVLSSSSATYAQ----VLSFLAAFGCLVMAIPAILigaigastdwnqtAYG 201
Cdd:PRK10484 239 P--VPFPTLFTGLILVNLfYWctnQSIVQRALGAKNLAEGQkgalLAAFFKLLGPLILVLPGII-------------AFH 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 202 LPdPKTTEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVF 281
Cdd:PRK10484 304 LY-GDGLPNADMAYPTLVNDVLPVPLVGFFAAVLFGAILSTFNGFLNSASTLFSLDIYKPIINPNASEKQLVKVGKKFGF 382
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 756761759 282 VFGASATAMA-LLTKTVYGLWYLSSDLVYIVIFPQLLCVL---FVKGTNTYGAVAGYVSGLFLRITG 344
Cdd:PRK10484 383 VLAIISMIVApLIANAPQGLYSYLQQLNGIYNVPILAIIIvgfFTKRVPALAAKVALGFGIILYIII 449
|
|
| PRK15419 |
PRK15419 |
sodium/proline symporter PutP; |
64-291 |
4.31e-07 |
|
sodium/proline symporter PutP;
Pssm-ID: 185317 Cd Length: 502 Bit Score: 52.33 E-value: 4.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 64 ALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALshpaVADIGFTAVHAKYQKPWLGTVDSSEVYSWLdSFLLLM 143
Cdd:PRK15419 168 AAATILYTFIGGFLAVSWTDTVQASLMIFALILTPVIVI----ISVGGFGDSLEVIKQKSIENVDMLKGLNFV-AIISLM 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 144 LGGIPW------QAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAyglpdpKTTEEADMILPI 217
Cdd:PRK15419 243 GWGLGYfgqphiLARFMAADSHHSIVHARRISMTWMILCLAGAVAVGFFGIAYFNEHPAVAG------AVNQNAERVFIE 316
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 756761759 218 VLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMA 291
Cdd:PRK15419 317 LAQILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKHASQKELVWVGRVMVLVVALVAIALA 390
|
|
| SLC5sbd_SMIT |
cd11491 |
Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT ... |
55-340 |
1.54e-06 |
|
Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT is a high-affinity myo-inositol transporter, and is expressed in brain, heart, kidney, and lung. Inhibition of myo-inositol uptake, through down-regulation of SMIT, may be a common mechanism of action of mood stabilizers, including lithium, carbamazepine, and valproate. SMIT is encoded by the SLC5A3 gene, which is a candidate gene for pathogenesis of nervous system dysfunction in Down syndrome (DS). The SNP, 21q22 near SLC5A3-MRPS6-KCNE2, has been associated with coronary heart disease, cardiovascular disease, and myocardial infarction. SMIT may also be involved in the pathogeneisis of congenital cataract. SMIT also plays roles in osteogenesis, bone formation, and bone mineral density determination. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271382 Cd Length: 609 Bit Score: 50.64 E-value: 1.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 55 DMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALSHPAvadiGFTAVHAKYQKPWLGTVDSSEVYS 134
Cdd:cd11491 149 NLYVSIILLLGLTALLTVTGGLAAVIYTDTLQAFLMIIGALTLMIISMMEIG----GFEGVKSRYMLASPNVTSILLTYN 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 135 WL-----------DSFLLL---MLGGIPW------------------QAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIP 182
Cdd:cd11491 225 LSntnsccvhpkkDAFKLLrdpTDEDVPWpgfilgqtpasiwywcadQVIVQRVLAAKSLSHAQGATLMAGFIKLLPLFI 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 183 AILIGAIGASTDWNQTAYGLPDP------KTTEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFAR 256
Cdd:cd11491 305 IVIPGMISRILFPDDIACINPEHcmqvcgSRAGCSNIAYPRLVMKIMPSGLRGLMMAVMIAALMSDLTSIFNSASTLFTL 384
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 257 NIYQLsFRQNASDKEIVWVMRITV-FVFGASATAMALLTKTVYGLWYLSSDLVYIVIFPQL----LCVLFVKGTNTYGAV 331
Cdd:cd11491 385 DVYKL-IRKKASSRELMIVGRIFVaVMVVISIAWIPVIQEMQGGQLYLYIQEVAAYLTPPVaslyLLAIFWKRTTEQGAF 463
|
....*....
gi 756761759 332 AGYVSGLFL 340
Cdd:cd11491 464 YGGMAGFVL 472
|
|
| SLC5sbd_SMVT |
cd11504 |
Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This ... |
21-340 |
1.01e-04 |
|
Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This multivitamin transporter SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate, and is essential for mediating biotin uptake into mammalian cells. SMVT is expressed in the placenta, intestine, heart, brain, lung, liver, kidney and pancreas. Biotin may regulate its own cellular uptake through participation in holocarboxylase synthetase-dependent chromatin remodeling events at SMVT promoter loci. The cis regulatory elements, Kruppel-like factor 4 and activator protein-2, regulate the activity of the human SMVT promoter in the intestine. Glycosylation of the hSMVT is important for its transport function. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271394 [Multi-domain] Cd Length: 527 Bit Score: 44.87 E-value: 1.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 21 MGGLLFIPALmgemfwaaaifsalgaTISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVG-LWISVP 99
Cdd:cd11504 134 MGVVLYAPAL----------------ALNAVTGFNLWISVLAMGVVCTFYTALGGLKAVIWTDVFQTVVMFAGqLAVIIV 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 100 FALSHPAVADIGFTAVHAKYQKPWLGTVDSSEVYS-WL----DSFLLLMLGGIPwQAYFQRVLSSSSATYAqVLSFLAAF 174
Cdd:cd11504 198 GSIEAGGIARVWRVAAESDRIDGFNLSPDPTIRHTfWTlvvgGVFNMLALYGVN-QAQVQRYLSSRTEKQA-KRSCYLVF 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 175 GCLVMAIPAI-LIGAIGASTdwnqtaYGLPDPKTTEEADMILPIVLQYLCPVYISFFGL-GAVSAAVMSSADSSILSASS 252
Cdd:cd11504 276 PGQQLSLCIGcLCGLVMFAR------YHECDPLKNGIVARSDQLVPYFVMDVLDGLPGLpGLFIACLFSGALSTISSAFN 349
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 253 MFA----RNIYQLSFRqNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIVIFP--QLLCV-LFVKGT 325
Cdd:cd11504 350 SLAtvtmEDLIVPKFP-DMTEERATLLSKGLAVGYGLLCLLMAYLASTMGQVLQAANSIFGMIGGPllGLFCLgMFFPCA 428
|
330
....*....|....*
gi 756761759 326 NTYGAVAGYVSGLFL 340
Cdd:cd11504 429 NSAGAVVGLLAGLFM 443
|
|
| PRK12488 |
PRK12488 |
cation/acetate symporter; |
45-339 |
8.93e-04 |
|
cation/acetate symporter;
Pssm-ID: 237114 [Multi-domain] Cd Length: 549 Bit Score: 41.71 E-value: 8.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 45 GATISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALSH----PAVADIGFTAVHAKYQ 120
Cdd:PRK12488 169 GKLIELLFGISYLYAVVIVGALMVLYVTFGGMLATTWVQIIKAVLLLSGTSFMAFMVLKHfgfsTEAMFASAVAVHAKGQ 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 121 KPWLGTVDSSEVYSWLDSFLLLMLGGIPWQAYFQRVLSSSSATYAQVlSFLAAFG--------CLVMAIPAILIgaIGAs 192
Cdd:PRK12488 249 AILAPGGLLSNPIDAISLGLGMMFGTAGLPHILMRFFTVSDAREARK-SVLYATGfigyfyllIIVVGFGAIVM--VGT- 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761759 193 tdwnQTAYGLPDPKTTEEADMilpiVLQYLCPVYISFFGLGAVSAAVMSSADSSI----LSASSMFARNIYQLSFRQ-NA 267
Cdd:PRK12488 325 ----EPSYRDAGGKIIGGGNM----VAVHLAQAVGGNLFLGFISAVAFATILAVVaglaLSGASAVSHDLYACVIRKgQA 396
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 756761759 268 SDKEIVWVMRITVFVFGASATAMALL--TKTVYGLWYLSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSGLF 339
Cdd:PRK12488 397 SEAQEMRVSKIATLGIGLLAVVLGLMfeSQNIAFLSGLVLAIAASVNFPVLFLSMFWKGLTTRGAVAGSYAGLV 470
|
|
| SLC5sbd_NIS |
cd11503 |
Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of ... |
30-96 |
9.95e-04 |
|
Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. NIS is expressed in the thyroid, colon, ovary, and in human breast cancers. It mediates the active transport and the concentration of iodide from the blood into thyroid follicular cells, a fundamental step in thyroid hormone biosynthesis, and is the basis of radioiodine therapy for thyroid cancer. Mutation in the SLC5A5 gene can result in a form of thyroid hormone dysgenesis. Human NIS exists mainly as a dimer stabilized by a disulfide bridge. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271393 Cd Length: 535 Bit Score: 41.75 E-value: 9.95e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 756761759 30 LMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWI 96
Cdd:cd11503 124 IVATMLYTGIVIYAPALILNQVTGLDIWASLFSTGIICTFYTTVGGMKAVIWTDVFQVVVMLSGFWA 190
|
|
| |
