high affinity choline transporter 1 isoform c [Homo sapiens]
sodium:solute symporter family protein( domain architecture ID 10183701)
sodium:solute symporter family protein similar to human high-affinity choline transporter 1 (CHT), also called solute carrier family 5 member 7, which is a sodium ion- and chloride ion-dependent transmembrane transporter that imports choline from the extracellular space into the neuron
List of domain hits
Name | Accession | Description | Interval | E-value | |||||
SLC5sbd_CHT | cd11474 | Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ... |
1-248 | 2.34e-103 | |||||
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family. : Pssm-ID: 271368 [Multi-domain] Cd Length: 464 Bit Score: 311.00 E-value: 2.34e-103
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Name | Accession | Description | Interval | E-value | |||||
SLC5sbd_CHT | cd11474 | Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ... |
1-248 | 2.34e-103 | |||||
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family. Pssm-ID: 271368 [Multi-domain] Cd Length: 464 Bit Score: 311.00 E-value: 2.34e-103
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PutP | COG0591 | Na+/proline symporter [Amino acid transport and metabolism]; |
1-252 | 3.21e-35 | |||||
Na+/proline symporter [Amino acid transport and metabolism]; Pssm-ID: 440356 [Multi-domain] Cd Length: 476 Bit Score: 133.40 E-value: 3.21e-35
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sss | TIGR00813 | transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ... |
1-195 | 1.64e-16 | |||||
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds] Pssm-ID: 273282 [Multi-domain] Cd Length: 407 Bit Score: 79.65 E-value: 1.64e-16
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SSF | pfam00474 | Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ... |
1-195 | 1.83e-12 | |||||
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score. Pssm-ID: 109527 [Multi-domain] Cd Length: 406 Bit Score: 67.36 E-value: 1.83e-12
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PRK10484 | PRK10484 | putative transporter; Provisional |
8-202 | 1.42e-07 | |||||
putative transporter; Provisional Pssm-ID: 236699 [Multi-domain] Cd Length: 523 Bit Score: 52.96 E-value: 1.42e-07
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Name | Accession | Description | Interval | E-value | |||||
SLC5sbd_CHT | cd11474 | Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ... |
1-248 | 2.34e-103 | |||||
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family. Pssm-ID: 271368 [Multi-domain] Cd Length: 464 Bit Score: 311.00 E-value: 2.34e-103
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SLC5sbd | cd10322 | Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ... |
1-220 | 3.98e-36 | |||||
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease. Pssm-ID: 271357 [Multi-domain] Cd Length: 454 Bit Score: 135.38 E-value: 3.98e-36
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PutP | COG0591 | Na+/proline symporter [Amino acid transport and metabolism]; |
1-252 | 3.21e-35 | |||||
Na+/proline symporter [Amino acid transport and metabolism]; Pssm-ID: 440356 [Multi-domain] Cd Length: 476 Bit Score: 133.40 E-value: 3.21e-35
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SLC5sbd_PutP | cd11475 | Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli ... |
41-197 | 1.01e-18 | |||||
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli PutP catalyzes the Na+-coupled uptake of proline with a stoichiometry of 1:1. The putP gene is part of the put operon; this operon in addition encodes a proline dehydrogenase, allowing the use of proline as a source of nitrogen and/or carbon. This subfamily also includes the Bacillus subtilis Na+/proline cotransporter (OpuE) which has an osmoprotective instead of catabolic role. Expression of the opuE gene is under osmotic control and different sigma factors contribute to its regulation; it is also a putative CcpA-activated gene. This subfamily belongs to the solute carrier 5 (SLC5) transporter family. Pssm-ID: 271369 Cd Length: 464 Bit Score: 86.41 E-value: 1.01e-18
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sss | TIGR00813 | transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ... |
1-195 | 1.64e-16 | |||||
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds] Pssm-ID: 273282 [Multi-domain] Cd Length: 407 Bit Score: 79.65 E-value: 1.64e-16
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SLC5sbd_DUR3 | cd11476 | Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is ... |
8-248 | 5.46e-16 | |||||
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is the yeast plasma membrane urea transporter. Saccharomyces cerevisiae DUR3 also transports polyamine. The polyamine uptake of S. cerevisiae DUR3 is activated upon its phosphorylation by polyamine transport protein kinase 2 (PTK2). S. cerevisiae DUR3 also appears to play a role in regulating the cellular boron concentration. This subfamily belongs to the solute carrier 5 (SLC5) transporter family. Pssm-ID: 271370 Cd Length: 493 Bit Score: 78.40 E-value: 5.46e-16
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SSF | pfam00474 | Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ... |
1-195 | 1.83e-12 | |||||
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score. Pssm-ID: 109527 [Multi-domain] Cd Length: 406 Bit Score: 67.36 E-value: 1.83e-12
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SLC5sbd_u1 | cd11477 | Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
12-216 | 4.90e-12 | |||||
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family. Pssm-ID: 271371 Cd Length: 493 Bit Score: 66.45 E-value: 4.90e-12
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SLC5sbd_SGLT1-like | cd10329 | Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily ... |
12-250 | 6.44e-12 | |||||
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily includes the solute-binding domain of SGLT proteins that cotransport Na+ with various solutes. Its members include: the human glucose (SGLT1, -2, -4, -5 ), chiro-inositol (SGLT5), and myo-inositol (SMIT) cotransporters. It also includes human SGLT3 which has been characterized as a glucose sensor and not a transporter. It belongs to the solute carrier 5 (SLC5) transporter family. Pssm-ID: 271363 Cd Length: 538 Bit Score: 66.06 E-value: 6.44e-12
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ActP | COG4147 | Na+(or H+)/acetate symporter ActP [Energy production and conversion]; |
19-252 | 6.55e-12 | |||||
Na+(or H+)/acetate symporter ActP [Energy production and conversion]; Pssm-ID: 443318 Cd Length: 526 Bit Score: 66.33 E-value: 6.55e-12
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SLC5sbd_u4 | cd11480 | Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
41-250 | 6.92e-12 | |||||
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family. Pssm-ID: 271374 Cd Length: 488 Bit Score: 65.99 E-value: 6.92e-12
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SLC5sbd_u3 | cd11479 | Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
8-195 | 4.41e-11 | |||||
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family. Pssm-ID: 271373 Cd Length: 454 Bit Score: 63.39 E-value: 4.41e-11
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SLC5sbd_NIS-like_u2 | cd11494 | uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
8-216 | 1.43e-10 | |||||
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters, SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family. Pssm-ID: 271385 [Multi-domain] Cd Length: 473 Bit Score: 61.85 E-value: 1.43e-10
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SLC5sbd_u2 | cd11478 | Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
12-252 | 2.38e-09 | |||||
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family. Pssm-ID: 271372 Cd Length: 496 Bit Score: 58.07 E-value: 2.38e-09
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SLC5sbd_YidK | cd10328 | uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; ... |
8-198 | 4.67e-08 | |||||
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Uncharacterized subfamily of the solute binding domain of the solute carrier 5 (SLC5) transporter family (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily includes the uncharacterized Escherichia coli YidK protein, and belongs to the solute carrier 5 (SLC5) transporter family. Pssm-ID: 271362 Cd Length: 472 Bit Score: 54.08 E-value: 4.67e-08
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SLC5sbd_vSGLT | cd10325 | Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute ... |
12-198 | 6.37e-08 | |||||
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; vSGLT transports D-galactose, D-glucose, and alpha-D-fucose, with a sugar specificity in the order of D-galactose >D-fucose >D-glucose. It transports one Na+ ion for each sugar molecule, and appears to function as a monomer. vSGLT has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). This subfamily belongs to the solute carrier 5 (SLC5) transporter family. Pssm-ID: 271360 Cd Length: 523 Bit Score: 53.85 E-value: 6.37e-08
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SLC5sbd_NIS-like_u3 | cd11495 | uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
8-196 | 7.43e-08 | |||||
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family. Pssm-ID: 271386 [Multi-domain] Cd Length: 473 Bit Score: 53.70 E-value: 7.43e-08
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PRK10484 | PRK10484 | putative transporter; Provisional |
8-202 | 1.42e-07 | |||||
putative transporter; Provisional Pssm-ID: 236699 [Multi-domain] Cd Length: 523 Bit Score: 52.96 E-value: 1.42e-07
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SLC5sbd_PanF | cd10327 | Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute ... |
60-196 | 1.56e-06 | |||||
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; PanF catalyzes the Na+-coupled uptake of extracellular pantothenate for coenzyme A biosynthesis in cells. This subfamily belongs to the solute carrier 5 (SLC5) transporter family. Pssm-ID: 212037 Cd Length: 472 Bit Score: 49.51 E-value: 1.56e-06
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PRK15419 | PRK15419 | sodium/proline symporter PutP; |
78-149 | 3.50e-06 | |||||
sodium/proline symporter PutP; Pssm-ID: 185317 Cd Length: 502 Bit Score: 48.47 E-value: 3.50e-06
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SLC5sbd_NIS-like | cd10326 | Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ... |
69-213 | 3.40e-05 | |||||
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and 2. SMCT1(the product of the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (product of the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subfamily belongs to the solute carrier 5 (SLC5) transporter family. Pssm-ID: 271361 [Multi-domain] Cd Length: 472 Bit Score: 45.24 E-value: 3.40e-05
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SLC5sbd_SGLT6 | cd11490 | Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human ... |
8-284 | 3.74e-05 | |||||
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human SGLT6 (also called KST1, SMIT2) is a chiro-inositol transporter, which also transports myo-inositol. It is encoded by the SLC5A11 gene. Xenopus Na1-glucose cotransporter type 1 (SGLT-1)-like protein is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family. Pssm-ID: 271381 Cd Length: 602 Bit Score: 45.28 E-value: 3.74e-05
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SLC5sbd_SGLT4 | cd11488 | Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 ... |
8-201 | 2.81e-04 | |||||
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 (hSGLT4) has been reported to be a low-affinity glucose transporter with unusual sugar selectivity: it transports D-mannose but not galactose or 3-O-methyl-D-glucoside. It is encoded by the SLC5A9 gene and is expressed in intestine, kidney, liver, brain, lung, trachea, uterus, and pancreas. hSLGT4 is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5 )transporter family. Pssm-ID: 271380 Cd Length: 605 Bit Score: 42.61 E-value: 2.81e-04
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SLC5sbd_SGLT2 | cd11487 | Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 ... |
90-198 | 8.63e-04 | |||||
Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 (hSGLT2) is a high-capacity, low-affinity glucose transporter, that plays an important role in renal glucose reabsorption. It is encoded by the SLC5A2 gene and expressed almost exclusively in renal proximal tubule cells. Mutations in hSGLT2 cause Familial Renal Glucosuria (FRG), a rare autosomal defect in glucose transport. hSGLT2 is a major drug target for regulating blood glucose levels in diabetes. hSGLT2 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family. Pssm-ID: 212056 [Multi-domain] Cd Length: 583 Bit Score: 41.06 E-value: 8.63e-04
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PRK12488 | PRK12488 | cation/acetate symporter; |
106-197 | 3.65e-03 | |||||
cation/acetate symporter; Pssm-ID: 237114 [Multi-domain] Cd Length: 549 Bit Score: 39.01 E-value: 3.65e-03
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Blast search parameters | ||||
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