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Conserved domains on  [gi|758818586|ref|NP_001291967|]
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zinc finger protein 33B isoform 3 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 12142358)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
271-660 3.13e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 3.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818586 271 KPFECNECGKAFSHKSALTLHQRTHTGEKPYQCNA--CGKTFYQKSDLTKHQRTHTGQKPYEC------YECGKSFCMNS 342
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNskslplSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818586 343 HLTVHQRTHtgekpfeCLECGKSFCQKSHLTQH----QRTHIGDKPYECNACGKTFYHKSVLTRHQIIHTGLKPYECYEc 418
Cdd:COG5048  112 SSSSNSNDN-------NLLSSHSLPPSSRDPQLpdllSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSN- 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818586 419 gktfclkSDLTIHQRTHTGEKPFACPECGKFFSHKSTLSQHYRTHTGEKPYECHECGKIF------YNKSYLTKHNRTHT 492
Cdd:COG5048  184 -------LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSS 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818586 493 GEKPYECNECGKTFCQKSQLTQHQRIHIG-EKPYECNECGKAFCHKSALIVHQRT--HTQE--KPYKCNE--CGKSFCVK 565
Cdd:COG5048  257 ASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRN 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818586 566 SGLILHERKHTGEKPYECNECGKSFSHKSSLTVHHRA---------HTGEKSCQCNECGKIFYRKSDLAKHQRSHTGEKP 636
Cdd:COG5048  337 DALKRHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQslqqykdlkNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRP 416

                        410       420
                 ....*....|....*....|....*.
gi 758818586 637 YECN--TCRKTFSQKSNLIVHQRTHI 660
Cdd:COG5048  417 YNCKnpPCSKSFNRHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
231-255 7.01e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.01e-03
                          10        20
                  ....*....|....*....|....*
gi 758818586  231 HLTRHQRVHTGEKHFQCNQCGKTFW 255
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
271-660 3.13e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 3.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818586 271 KPFECNECGKAFSHKSALTLHQRTHTGEKPYQCNA--CGKTFYQKSDLTKHQRTHTGQKPYEC------YECGKSFCMNS 342
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNskslplSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818586 343 HLTVHQRTHtgekpfeCLECGKSFCQKSHLTQH----QRTHIGDKPYECNACGKTFYHKSVLTRHQIIHTGLKPYECYEc 418
Cdd:COG5048  112 SSSSNSNDN-------NLLSSHSLPPSSRDPQLpdllSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSN- 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818586 419 gktfclkSDLTIHQRTHTGEKPFACPECGKFFSHKSTLSQHYRTHTGEKPYECHECGKIF------YNKSYLTKHNRTHT 492
Cdd:COG5048  184 -------LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSS 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818586 493 GEKPYECNECGKTFCQKSQLTQHQRIHIG-EKPYECNECGKAFCHKSALIVHQRT--HTQE--KPYKCNE--CGKSFCVK 565
Cdd:COG5048  257 ASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRN 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818586 566 SGLILHERKHTGEKPYECNECGKSFSHKSSLTVHHRA---------HTGEKSCQCNECGKIFYRKSDLAKHQRSHTGEKP 636
Cdd:COG5048  337 DALKRHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQslqqykdlkNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRP 416

                        410       420
                 ....*....|....*....|....*.
gi 758818586 637 YECN--TCRKTFSQKSNLIVHQRTHI 660
Cdd:COG5048  417 YNCKnpPCSKSFNRHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
259-284 9.55e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.55e-04
                          10        20
                  ....*....|....*....|....*.
gi 758818586  259 NLTKHQRSHTGEKPFECNECGKAFSH 284
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
231-255 7.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.01e-03
                          10        20
                  ....*....|....*....|....*
gi 758818586  231 HLTRHQRVHTGEKHFQCNQCGKTFW 255
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 355-403 7.69e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 7.69e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 758818586 355 KPFeCLECGKSFCQKSHLTQHQRThigdKPYECNACGKTFYHKSVLTRH 403
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKA----KHFKCHICHKKLYTAGGLAVH 44
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
271-660 3.13e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.87  E-value: 3.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818586 271 KPFECNECGKAFSHKSALTLHQRTHTGEKPYQCNA--CGKTFYQKSDLTKHQRTHTGQKPYEC------YECGKSFCMNS 342
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNskslplSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818586 343 HLTVHQRTHtgekpfeCLECGKSFCQKSHLTQH----QRTHIGDKPYECNACGKTFYHKSVLTRHQIIHTGLKPYECYEc 418
Cdd:COG5048  112 SSSSNSNDN-------NLLSSHSLPPSSRDPQLpdllSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSN- 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818586 419 gktfclkSDLTIHQRTHTGEKPFACPECGKFFSHKSTLSQHYRTHTGEKPYECHECGKIF------YNKSYLTKHNRTHT 492
Cdd:COG5048  184 -------LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSS 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818586 493 GEKPYECNECGKTFCQKSQLTQHQRIHIG-EKPYECNECGKAFCHKSALIVHQRT--HTQE--KPYKCNE--CGKSFCVK 565
Cdd:COG5048  257 ASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRN 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818586 566 SGLILHERKHTGEKPYECNECGKSFSHKSSLTVHHRA---------HTGEKSCQCNECGKIFYRKSDLAKHQRSHTGEKP 636
Cdd:COG5048  337 DALKRHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQslqqykdlkNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRP 416

                        410       420
                 ....*....|....*....|....*.
gi 758818586 637 YECN--TCRKTFSQKSNLIVHQRTHI 660
Cdd:COG5048  417 YNCKnpPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
217-562 7.28e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 7.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818586 217 FECNECGKAFWEKSHLTRHQRVHTGEKHFQCNQ--CGKTFWEKSNLTKHQRSHTGEKPFEC----------------NEC 278
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNskslplsnskasssslSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818586 279 GKAFSHKSALTLHQRTHTGEKPYQCNACGKTFYQKSDLTKHQRTHTGQK-------PYECYECGKSFCMNSHLTVHQRTH 351
Cdd:COG5048  114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSKDPSSNLSLLISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818586 352 TGEKPFECLECGKSFCQKSHLTQHQRTHIGDKPYECNACG------------------------KTFYHKSVLTRHQIIH 407
Cdd:COG5048  194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSqlspksllsqspsslsssdssssaSESPRSSLPTASSQSS 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818586 408 TG-----------LKPYECYECGKTFCLKSDLTIHQRT--HTGE--KPFACPE--CGKFFSHKSTLSQHYRTHTGEKPYE 470
Cdd:COG5048  274 SPnesdsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK 353

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818586 471 CHECGKIFYNKSYLTK-------HNRTHTGEKPYEC--NECGKTFCQKSQLTQHQRIHIGEKPYECN--ECGKAFCHKSA 539
Cdd:COG5048  354 EKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYN 433

                        410       420
                 ....*....|....*....|...
gi 758818586 540 LIVHQRTHTQEKPYKCNECGKSF 562
Cdd:COG5048  434 LIPHKKIHTNHAPLLCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
326-653 1.13e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 1.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818586 326 QKPYECYECGKSFCMNSHLTVHQRTHTGEKPFECL--ECGKSFCQKSHLTQHQRTHIGDKPYECNacgKTFYHKSVLTRH 403
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASS 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818586 404 QIIHtglkpyecyECGKTFCLKSDLTIHQRTHTGEKPFACPECGKFFSHKSTLSQHYRTHTGEK-------PYECHECGK 476
Cdd:COG5048  108 SSLS---------SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSK 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818586 477 IFYNKSYLTKHNRTHTGEKPYECNECGKTFCQKSQLTQHQRIHIGEKPYECNECGkAFCHKSAL-------IVHQRTHTQ 549
Cdd:COG5048  179 DPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS-QLSPKSLLsqspsslSSSDSSSSA 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818586 550 EKPYKCNECGKSFCVKSGLILHERKHTG-EKPYECNECGKSFSHKSSLTVHHRA--HTGE--KSCQCNE--CGKIFYRKS 622
Cdd:COG5048  258 SESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRND 337

                        330       340       350
                 ....*....|....*....|....*....|.
gi 758818586 623 DLAKHQRSHTGEKPYECNTCRKTFSQKSNLI 653
Cdd:COG5048  338 ALKRHILLHTSISPAKEKLLNSSSKFSPLLN 368
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
86-506 4.56e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 4.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818586  86 NTLSHRENTLQHEKIQTLDHNFEYSI----CQETLLEKAVFNTRKRENAEENNCDYNEFGRTFCDSSSLLFHQIP----- 156
Cdd:COG5048   11 SNNSVLSSTPKSTLKSLSNAPRPDSCpnctDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRThhnnp 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818586 157 ------PSKDSHYEFSDCEKFLCvKSTLSKHDGvPVKHYDCGESGNNFRRKLCLSqlqkgdkgeKHFECNECgkafwEKS 230
Cdd:COG5048   91 sdlnskSLPLSNSKASSSSLSSS-SSNSNDNNL-LSSHSLPPSSRDPQLPDLLSI---------SNLRNNPL-----PGN 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818586 231 HLTRHQRVHTGEKHFQCNQ--CGKTFWEKSNLTKHQRSHTGEKPFECNECGKAFSHKSALTLHQRTHTGEKPYQCNACGK 308
Cdd:COG5048  155 NSSSVNTPQSNSLHPPLPAnsLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQ 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818586 309 TF------YQKSDLTKHQRTHTGQKPYECYECGKSFCMNSHLTVHQRTHTG-EKPFECLECGKSFCQKSHLTQHQRTHI- 380
Cdd:COG5048  235 LSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVNh 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818586 381 ---GDKPYEC--NACGKTFYHKSVLTRHQIIHTGLKPYECYEC-------GKTFCLKSDLTIHQRTHTGEKPFAC--PEC 446
Cdd:COG5048  315 sgeSLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSC 394

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 758818586 447 GKFFSHKSTLSQHYRTHTGEKPYECH--ECGKIFYNKSYLTKHNRTHTGEKPYECNECGKTF 506
Cdd:COG5048  395 IRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
zf-H2C2_2 pfam13465
Zinc-finger double domain;
259-284 9.55e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.55e-04
                          10        20
                  ....*....|....*....|....*.
gi 758818586  259 NLTKHQRSHTGEKPFECNECGKAFSH 284
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
568-592 4.08e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.08e-03
                          10        20
                  ....*....|....*....|....*
gi 758818586  568 LILHERKHTGEKPYECNECGKSFSH 592
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
315-338 4.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.12e-03
                          10        20
                  ....*....|....*....|....
gi 758818586  315 DLTKHQRTHTGQKPYECYECGKSF 338
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
549-608 4.77e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 4.77e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 758818586 549 QEKPYKCNECGKSFCVKSGLILHERKHTGEKPYECN--ECGKSFSHKSSLTVHHRAHTGEKS 608
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPS 91
zf-H2C2_2 pfam13465
Zinc-finger double domain;
427-452 5.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.59e-03
                          10        20
                  ....*....|....*....|....*.
gi 758818586  427 DLTIHQRTHTGEKPFACPECGKFFSH 452
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
343-366 6.48e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.48e-03
                          10        20
                  ....*....|....*....|....
gi 758818586  343 HLTVHQRTHTGEKPFECLECGKSF 366
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
539-562 6.81e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.81e-03
                          10        20
                  ....*....|....*....|....
gi 758818586  539 ALIVHQRTHTQEKPYKCNECGKSF 562
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
231-255 7.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.01e-03
                          10        20
                  ....*....|....*....|....*
gi 758818586  231 HLTRHQRVHTGEKHFQCNQCGKTFW 255
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
623-648 7.44e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.44e-03
                          10        20
                  ....*....|....*....|....*.
gi 758818586  623 DLAKHQRSHTGEKPYECNTCRKTFSQ 648
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 355-403 7.69e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 7.69e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 758818586 355 KPFeCLECGKSFCQKSHLTQHQRThigdKPYECNACGKTFYHKSVLTRH 403
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKA----KHFKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
483-506 9.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.05e-03
                          10        20
                  ....*....|....*....|....
gi 758818586  483 YLTKHNRTHTGEKPYECNECGKTF 506
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
512-534 9.80e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.80e-03
                          10        20
                  ....*....|....*....|...
gi 758818586  512 LTQHQRIHIGEKPYECNECGKAF 534
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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