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Conserved domains on  [gi|758818551|ref|NP_001292006|]
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alpha/beta-tubulin-N-acetyltransferase 9 isoform 2 [Homo sapiens]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 11447364)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
SCOP:  3000403

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
9-165 3.69e-24

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 93.53  E-value: 3.69e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818551   9 LLGKKVVLVPYTSEHVPRYHEWMKSEELQRLTASEPLTLEQEYAMQCSWQEDADKCTFIVLDAEKwqaqpgaTEESCMVG 88
Cdd:COG1670    3 LETERLRLRPLRPEDAEALAELLNDPEVARYLPGPPYSLEEARAWLERLLADWADGGALPFAIED-------KEDGELIG 75
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 758818551  89 DVNLFLTDLEDLTlGEIEVMIAePSCRGKGLGTEAVLAMLSYGVTTLGLTKFEAKIGQGNEPSIRMFQKLHFEQVAT 165
Cdd:COG1670   76 VVGLYDIDRANRS-AEIGYWLA-PAYWGKGYATEALRALLDYAFEELGLHRVEAEVDPDNTASIRVLEKLGFRLEGT 150
 
Name Accession Description Interval E-value
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
9-165 3.69e-24

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 93.53  E-value: 3.69e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818551   9 LLGKKVVLVPYTSEHVPRYHEWMKSEELQRLTASEPLTLEQEYAMQCSWQEDADKCTFIVLDAEKwqaqpgaTEESCMVG 88
Cdd:COG1670    3 LETERLRLRPLRPEDAEALAELLNDPEVARYLPGPPYSLEEARAWLERLLADWADGGALPFAIED-------KEDGELIG 75
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 758818551  89 DVNLFLTDLEDLTlGEIEVMIAePSCRGKGLGTEAVLAMLSYGVTTLGLTKFEAKIGQGNEPSIRMFQKLHFEQVAT 165
Cdd:COG1670   76 VVGLYDIDRANRS-AEIGYWLA-PAYWGKGYATEALRALLDYAFEELGLHRVEAEVDPDNTASIRVLEKLGFRLEGT 150
Acetyltransf_3 pfam13302
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
14-161 1.47e-23

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 379112 [Multi-domain]  Cd Length: 139  Bit Score: 91.25  E-value: 1.47e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818551   14 VVLVPYTSEHVPRYHEWMKSEELQRLTASEPLTLEQEYA-MQCSWQEDADK--CTFIVLDAEkwqaqpgateeSCMVGDV 90
Cdd:pfam13302   2 LLLRPLTEEDAEALFELLSDPEVMRYGVPWPLTLEEAREwLARIWAADEAErgYGWAIELKD-----------TGFIGSI 70
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 758818551   91 NLFLTDLEDLTLgEIEVMIAePSCRGKGLGTEAVLAMLSYGVTTLGLTKFEAKIGQGNEPSIRMFQKLHFE 161
Cdd:pfam13302  71 GLYDIDGEPERA-ELGYWLG-PDYWGKGYATEAVRALLEYAFEELGLPRLVARIDPENTASRRVLEKLGFK 139
PRK15130 PRK15130
spermidine N1-acetyltransferase; Provisional
104-161 2.89e-04

spermidine N1-acetyltransferase; Provisional


Pssm-ID: 237916  Cd Length: 186  Bit Score: 40.17  E-value: 2.89e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 758818551 104 EIEVMIAePSCRGKGLGTEAVLAMLSYGVTTLGLTKFEAKIGQGNEPSIRMFQKLHFE 161
Cdd:PRK15130  85 EFQIIIS-PEYQGKGLATRAAKLAMDYGFTVLNLYKLYLIVDKENEKAIHIYRKLGFE 141
 
Name Accession Description Interval E-value
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
9-165 3.69e-24

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 93.53  E-value: 3.69e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818551   9 LLGKKVVLVPYTSEHVPRYHEWMKSEELQRLTASEPLTLEQEYAMQCSWQEDADKCTFIVLDAEKwqaqpgaTEESCMVG 88
Cdd:COG1670    3 LETERLRLRPLRPEDAEALAELLNDPEVARYLPGPPYSLEEARAWLERLLADWADGGALPFAIED-------KEDGELIG 75
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 758818551  89 DVNLFLTDLEDLTlGEIEVMIAePSCRGKGLGTEAVLAMLSYGVTTLGLTKFEAKIGQGNEPSIRMFQKLHFEQVAT 165
Cdd:COG1670   76 VVGLYDIDRANRS-AEIGYWLA-PAYWGKGYATEALRALLDYAFEELGLHRVEAEVDPDNTASIRVLEKLGFRLEGT 150
Acetyltransf_3 pfam13302
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
14-161 1.47e-23

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 379112 [Multi-domain]  Cd Length: 139  Bit Score: 91.25  E-value: 1.47e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818551   14 VVLVPYTSEHVPRYHEWMKSEELQRLTASEPLTLEQEYA-MQCSWQEDADK--CTFIVLDAEkwqaqpgateeSCMVGDV 90
Cdd:pfam13302   2 LLLRPLTEEDAEALFELLSDPEVMRYGVPWPLTLEEAREwLARIWAADEAErgYGWAIELKD-----------TGFIGSI 70
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 758818551   91 NLFLTDLEDLTLgEIEVMIAePSCRGKGLGTEAVLAMLSYGVTTLGLTKFEAKIGQGNEPSIRMFQKLHFE 161
Cdd:pfam13302  71 GLYDIDGEPERA-ELGYWLG-PDYWGKGYATEAVRALLEYAFEELGLPRLVARIDPENTASRRVLEKLGFK 139
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
47-160 2.56e-08

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 50.21  E-value: 2.56e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818551   47 LEQEYAMQCSWQEDADKCTFIVLDAEKWqaqpgateescmVGDVNLFLTDLEDLTlGEIEVMIAEPSCRGKGLGTEAVLA 126
Cdd:pfam00583  17 PDEPLDLLEDWDEDASEGFFVAEEDGEL------------VGFASLSIIDDEPPV-GEIEGLAVAPEYRGKGIGTALLQA 83
                          90       100       110
                  ....*....|....*....|....*....|....
gi 758818551  127 MLSYGVtTLGLTKFEAKIGQGNEPSIRMFQKLHF 160
Cdd:pfam00583  84 LLEWAR-ERGCERIFLEVAADNLAAIALYEKLGF 116
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
103-165 1.66e-07

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 48.84  E-value: 1.66e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 758818551 103 GEIEVMIAePSCRGKGLGT---EAVLAMLsygvTTLGLTKFEAKIGQGNEPSIRMFQKLHFEQVAT 165
Cdd:COG1247   82 AEESIYVD-PDARGRGIGRallEALIERA----RARGYRRLVAVVLADNEASIALYEKLGFEEVGT 142
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
88-161 2.84e-06

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 43.86  E-value: 2.84e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 758818551   88 GDVNLFLTDLEDLTLGEIEVMIAEPSCRGKGLGTEAVLAmLSYGVTTLGLTKFeAKIGQGNEPSIRMFQKLHFE 161
Cdd:pfam08445   7 GDTGELAAWCLRLPGGELGALQTLPEHRRRGLGSRLVAA-LARGIAERGITPF-AVVVAGNTPSRRLYEKLGFR 78
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
103-169 1.67e-04

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 39.25  E-value: 1.67e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 758818551 103 GEIEVMIAEPSCRGKGLGTEAVLAMLSY----GVTTLGLTkfeakIGQGNEPSIRMFQKLHFEQVATSSVF 169
Cdd:COG0456   14 AEIEDLAVDPEYRGRGIGRALLEAALERarerGARRLRLE-----VREDNEAAIALYEKLGFEEVGERPNY 79
PRK15130 PRK15130
spermidine N1-acetyltransferase; Provisional
104-161 2.89e-04

spermidine N1-acetyltransferase; Provisional


Pssm-ID: 237916  Cd Length: 186  Bit Score: 40.17  E-value: 2.89e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 758818551 104 EIEVMIAePSCRGKGLGTEAVLAMLSYGVTTLGLTKFEAKIGQGNEPSIRMFQKLHFE 161
Cdd:PRK15130  85 EFQIIIS-PEYQGKGLATRAAKLAMDYGFTVLNLYKLYLIVDKENEKAIHIYRKLGFE 141
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
87-181 3.63e-04

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 39.27  E-value: 3.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 758818551  87 VGDVNLFLTDLEDltlGEIEVMIAEPSCRGKGLGTEAVLAMLSYGVtTLGLTKFEAKIGQGNEPSIRMFQKLHFEQVATS 166
Cdd:COG0454   46 IGFAGLRRLDDKV---LELKRLYVLPEYRGKGIGKALLEALLEWAR-ERGCTALELDTLDGNPAAIRFYERLGFKEIERY 121
                         90
                 ....*....|....*
gi 758818551 167 SVFQEVTLRLTVSES 181
Cdd:COG0454  122 VAYVGGEFEKELSLS 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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