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Conserved domains on  [gi|762205487|ref|NP_001292134|]
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DEP domain-containing protein 1A [Rattus norvegicus]

Protein Classification

Rho GTPase-activating protein( domain architecture ID 10138387)

Rho GTPase-activating protein for Rho/Rac/Cdc42-like small GTPases that act as molecular switches, active in their GTP-bound form but inactive when bound to GDP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEP_BRCC3 cd04447
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in BBRC3-like proteins. BBRC3, also ...
 15-106 7.21e-58

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in BBRC3-like proteins. BBRC3, also known as DEPDC1B, is a DEP containing protein of unknown function.


:

Pssm-ID: 239894  Cd Length: 92  Bit Score: 191.98  E-value: 7.21e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762205487  15 KLWNEVTTSFRVGMPLRKHRQHLKKYSNCFTAVEAVDWLYDLLRSNSNFGPEVTRQQTIQLLRKFLKNHVIEDIKGRWGS 94
Cdd:cd04447    1 KLWNEVTELFRAGMPLRKHRQHFKSYENCFTASEAVDWLHELLRSNSNFGPEVTRQQTVQLLKKFLKNHVIEDIKGRWGK 80

                         90
                 ....*....|..
gi 762205487  95 ENLDDNNQLFRF 106
Cdd:cd04447   81 EDLEDNNHLYRF 92
RhoGAP_BRCC3-like cd04405
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 182-309 2.48e-49

RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239870  Cd Length: 235  Bit Score: 173.67  E-value: 2.48e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762205487 182 ISQEDVEDVWRYVTMIYLQTILGVPSIEELINPNQVIPQYIMYNM------ANTSKHGVVILQNKSeDLPHWVLSAMKCL 255
Cdd:cd04405    1 LSPEVVEEIWKEQTLIRLLQLVGLPLLEELLDPALVNPKHISYNMdpdvytSNYLDREVVKLFSKS-QLDHWLLSAMDCL 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 762205487 256 ANWPRC--NDTNSLTYV------GFERDVFKTIADYFLDLPEPLLTFEYYELFVNILVVCGY 309
Cdd:cd04405   80 ANWPDQlvVDVSRPLYSqhdmlsGFKRLLFKTIAKYYGQLKEPLLTFHLFDIFVGILELLGN 141
RhoGAP super family cl02570
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 579-687 1.07e-35

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


The actual alignment was detected with superfamily member cd04405:

Pssm-ID: 470621  Cd Length: 235  Bit Score: 135.15  E-value: 1.07e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762205487 579 VLTGTQSLLQPHLERVAINALQLCCLLLPPPNRRKLQLLMRMISRMSQNvDLPKLHEEIGTRSLMINTFSRCVLCCAeev 658
Cdd:cd04405  131 IFVGILELLGNGKEEVALEALQLCLLLLPPASRRELRRLLRFMARAAKN-DMPRLHKEIENRMLVKQTFSRAILCSK--- 206

                         90       100
                 ....*....|....*....|....*....
gi 762205487 659 DLDELLASRLVSFLMDHHQEILQVPTYLQ 687
Cdd:cd04405  207 DLDEGLADLLVLFLMDHHQDIFKVPGSLH 235
 
Name Accession Description Interval E-value
DEP_BRCC3 cd04447
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in BBRC3-like proteins. BBRC3, also ...
 15-106 7.21e-58

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in BBRC3-like proteins. BBRC3, also known as DEPDC1B, is a DEP containing protein of unknown function.


Pssm-ID: 239894  Cd Length: 92  Bit Score: 191.98  E-value: 7.21e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762205487  15 KLWNEVTTSFRVGMPLRKHRQHLKKYSNCFTAVEAVDWLYDLLRSNSNFGPEVTRQQTIQLLRKFLKNHVIEDIKGRWGS 94
Cdd:cd04447    1 KLWNEVTELFRAGMPLRKHRQHFKSYENCFTASEAVDWLHELLRSNSNFGPEVTRQQTVQLLKKFLKNHVIEDIKGRWGK 80

                         90
                 ....*....|..
gi 762205487  95 ENLDDNNQLFRF 106
Cdd:cd04447   81 EDLEDNNHLYRF 92
RhoGAP_BRCC3-like cd04405
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 182-309 2.48e-49

RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239870  Cd Length: 235  Bit Score: 173.67  E-value: 2.48e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762205487 182 ISQEDVEDVWRYVTMIYLQTILGVPSIEELINPNQVIPQYIMYNM------ANTSKHGVVILQNKSeDLPHWVLSAMKCL 255
Cdd:cd04405    1 LSPEVVEEIWKEQTLIRLLQLVGLPLLEELLDPALVNPKHISYNMdpdvytSNYLDREVVKLFSKS-QLDHWLLSAMDCL 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 762205487 256 ANWPRC--NDTNSLTYV------GFERDVFKTIADYFLDLPEPLLTFEYYELFVNILVVCGY 309
Cdd:cd04405   80 ANWPDQlvVDVSRPLYSqhdmlsGFKRLLFKTIAKYYGQLKEPLLTFHLFDIFVGILELLGN 141
RhoGAP_BRCC3-like cd04405
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 579-687 1.07e-35

RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239870  Cd Length: 235  Bit Score: 135.15  E-value: 1.07e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762205487 579 VLTGTQSLLQPHLERVAINALQLCCLLLPPPNRRKLQLLMRMISRMSQNvDLPKLHEEIGTRSLMINTFSRCVLCCAeev 658
Cdd:cd04405  131 IFVGILELLGNGKEEVALEALQLCLLLLPPASRRELRRLLRFMARAAKN-DMPRLHKEIENRMLVKQTFSRAILCSK--- 206

                         90       100
                 ....*....|....*....|....*....
gi 762205487 659 DLDELLASRLVSFLMDHHQEILQVPTYLQ 687
Cdd:cd04405  207 DLDEGLADLLVLFLMDHHQDIFKVPGSLH 235
DEP pfam00610
Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for ...
 27-106 9.76e-18

Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit.


Pssm-ID: 459867  Cd Length: 71  Bit Score: 78.01  E-value: 9.76e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762205487   27 GMPLRKHRQHLKKYSNCFTAVEAVDWLYDLlrsnsnfGPEVTRQQTIQLLRKFLKNHVIEDIKGRWGseNLDDNNQLFRF 106
Cdd:pfam00610   1 GVKLKDRRKHLKTYPNCFTGSEAVDWLMDN-------LEIITREEAVELGQLLLDQGLIHHVGDKHG--LFKDSYYFYRF 71
DEP smart00049
Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in ...
 24-107 5.17e-16

Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in signalling proteins that contain PH, rasGEF, rhoGEF, rhoGAP, RGS, PDZ domains. DEP domain in Drosophila dishevelled is essential to rescue planar polarity defects and induce JNK signalling (Cell 94, 109-118).


Pssm-ID: 214489  Cd Length: 77  Bit Score: 73.47  E-value: 5.17e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762205487    24 FRVGMPLRKHRQHLKKYSNCFTAVEAVDWLYDLLrsnsnfgPEVTRQQTIQLLRKFLKNHVIEDIKGrWGSENLDDNNQL 103
Cdd:smart00049   1 PETGLKLRDRKYFLKTYPNCFTGSELVDWLMDNL-------EIIDREEAVHLGQLLLDEGLIHHVNG-PNKHTFKDSKAL 72


                   ....
gi 762205487   104 FRFP 107
Cdd:smart00049  73 YRFT 76
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 253-304 1.79e-03

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 39.45  E-value: 1.79e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 762205487  253 KCLANWPRCNDTNSLTyvgferDVFKtiaDYFLDLPEPLLTFEYYELFVNIL 304
Cdd:pfam00620  42 PDVDLDLEEEDVHVVA------SLLK---LFLRELPEPLLTFELYEEFIEAA 84
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 263-324 6.05e-03

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 38.40  E-value: 6.05e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 762205487   263 DTNSLTyvgferDVFKTiadYFLDLPEPLLTFEYYELFVNILvvcgyiTVSDKTSGIHKIQD 324
Cdd:smart00324  55 DVHDVA------GLLKL---FLRELPEPLITYELYEEFIEAA------KLEDETERLRALRE 101
 
Name Accession Description Interval E-value
DEP_BRCC3 cd04447
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in BBRC3-like proteins. BBRC3, also ...
 15-106 7.21e-58

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in BBRC3-like proteins. BBRC3, also known as DEPDC1B, is a DEP containing protein of unknown function.


Pssm-ID: 239894  Cd Length: 92  Bit Score: 191.98  E-value: 7.21e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762205487  15 KLWNEVTTSFRVGMPLRKHRQHLKKYSNCFTAVEAVDWLYDLLRSNSNFGPEVTRQQTIQLLRKFLKNHVIEDIKGRWGS 94
Cdd:cd04447    1 KLWNEVTELFRAGMPLRKHRQHFKSYENCFTASEAVDWLHELLRSNSNFGPEVTRQQTVQLLKKFLKNHVIEDIKGRWGK 80

                         90
                 ....*....|..
gi 762205487  95 ENLDDNNQLFRF 106
Cdd:cd04447   81 EDLEDNNHLYRF 92
RhoGAP_BRCC3-like cd04405
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 182-309 2.48e-49

RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239870  Cd Length: 235  Bit Score: 173.67  E-value: 2.48e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762205487 182 ISQEDVEDVWRYVTMIYLQTILGVPSIEELINPNQVIPQYIMYNM------ANTSKHGVVILQNKSeDLPHWVLSAMKCL 255
Cdd:cd04405    1 LSPEVVEEIWKEQTLIRLLQLVGLPLLEELLDPALVNPKHISYNMdpdvytSNYLDREVVKLFSKS-QLDHWLLSAMDCL 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 762205487 256 ANWPRC--NDTNSLTYV------GFERDVFKTIADYFLDLPEPLLTFEYYELFVNILVVCGY 309
Cdd:cd04405   80 ANWPDQlvVDVSRPLYSqhdmlsGFKRLLFKTIAKYYGQLKEPLLTFHLFDIFVGILELLGN 141
RhoGAP_BRCC3-like cd04405
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 579-687 1.07e-35

RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239870  Cd Length: 235  Bit Score: 135.15  E-value: 1.07e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762205487 579 VLTGTQSLLQPHLERVAINALQLCCLLLPPPNRRKLQLLMRMISRMSQNvDLPKLHEEIGTRSLMINTFSRCVLCCAeev 658
Cdd:cd04405  131 IFVGILELLGNGKEEVALEALQLCLLLLPPASRRELRRLLRFMARAAKN-DMPRLHKEIENRMLVKQTFSRAILCSK--- 206

                         90       100
                 ....*....|....*....|....*....
gi 762205487 659 DLDELLASRLVSFLMDHHQEILQVPTYLQ 687
Cdd:cd04405  207 DLDEGLADLLVLFLMDHHQDIFKVPGSLH 235
DEP pfam00610
Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for ...
 27-106 9.76e-18

Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP); The DEP domain is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit.


Pssm-ID: 459867  Cd Length: 71  Bit Score: 78.01  E-value: 9.76e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762205487   27 GMPLRKHRQHLKKYSNCFTAVEAVDWLYDLlrsnsnfGPEVTRQQTIQLLRKFLKNHVIEDIKGRWGseNLDDNNQLFRF 106
Cdd:pfam00610   1 GVKLKDRRKHLKTYPNCFTGSEAVDWLMDN-------LEIITREEAVELGQLLLDQGLIHHVGDKHG--LFKDSYYFYRF 71
DEP smart00049
Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in ...
 24-107 5.17e-16

Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in signalling proteins that contain PH, rasGEF, rhoGEF, rhoGAP, RGS, PDZ domains. DEP domain in Drosophila dishevelled is essential to rescue planar polarity defects and induce JNK signalling (Cell 94, 109-118).


Pssm-ID: 214489  Cd Length: 77  Bit Score: 73.47  E-value: 5.17e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762205487    24 FRVGMPLRKHRQHLKKYSNCFTAVEAVDWLYDLLrsnsnfgPEVTRQQTIQLLRKFLKNHVIEDIKGrWGSENLDDNNQL 103
Cdd:smart00049   1 PETGLKLRDRKYFLKTYPNCFTGSELVDWLMDNL-------EIIDREEAVHLGQLLLDEGLIHHVNG-PNKHTFKDSKAL 72


                   ....
gi 762205487   104 FRFP 107
Cdd:smart00049  73 YRFT 76
DEP cd04371
DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first ...
 24-105 7.28e-15

DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is present. New studies show that the DEP domain of Sst2, a yeast RGS protein is necessary and sufficient for receptor interaction.


Pssm-ID: 239836  Cd Length: 81  Bit Score: 70.06  E-value: 7.28e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762205487  24 FRVGMPLRKHRQHLKKYSNCFTAVEAVDWLYDllrsnsnFGPEVTRQQTIQLLRKFLKNHVIEDIKGrwGSENLDDNNQL 103
Cdd:cd04371    9 SDSGVPIKDRKYHLKTYPNCFTGSELVDWLLD-------NLEAITREEAVELGQALLKHGLIHHVSD--DKHTFRDSYAL 79


                 ..
gi 762205487 104 FR 105
Cdd:cd04371   80 YR 81
DEP_DEPDC4 cd04446
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a ...
 17-105 3.10e-09

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a DEP domain containing protein of unknown function.


Pssm-ID: 239893  Cd Length: 95  Bit Score: 54.68  E-value: 3.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762205487  17 WNEVTTSFRVGMPLRKHRQHLKKYSNCFTAVEAVDWLYDLLRSNSNFG-PEVTRQQTIQLLRKFLKNHVIEDIKGRWGSE 95
Cdd:cd04446    1 WNSIIDALQTQVEVKKRRHNLKSYHDCFLGSEAVDVVLAHLMQNKYFGdVDVPRAKAVRLCQALMDCRVFEAVGTKVFKK 80

                         90
                 ....*....|....*
gi 762205487  96 N-----LDDNNQLFR 105
Cdd:cd04446   81 KkravfEDSSSSLYR 95
DEP_PIKfyve cd04448
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange ...
 16-53 3.70e-06

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol phosphate kinase) domain. PIKfyve-like proteins are important phosphatidylinositol (3)-monophosphate (PtdIns(3)P)-5-kinases, producing PtdIns(3,5)P2, which plays a major role in multivesicular body (MVB) sorting and control of retrograde traffic from the vacuole back to the endosome and/or Golgi. PIKfyve itself has been shown to be play a role in regulating early-endosome-to-trans-Golgi network (TGN) retrograde trafficking.


Pssm-ID: 239895  Cd Length: 81  Bit Score: 45.51  E-value: 3.70e-06
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 762205487  16 LWNEVTTSfRVGMPLRKHRQHLKKYSNCFTAVEAVDWL 53
Cdd:cd04448    2 LWEKICRS-STGIEFQDHRYRLRTYTNCILGKELVNWL 38
DEP_DEPDC5-like cd04449
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in ...
 34-91 2.49e-04

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function.


Pssm-ID: 239896  Cd Length: 83  Bit Score: 40.34  E-value: 2.49e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 762205487  34 RQHLKKYSNCFTAVEAVDWLYDllrsnsNFGPEVTRQQTIQLLRKFLKNHVIEDIKGR 91
Cdd:cd04449   20 SWHKGLPSNCFIGSEAVSWLIN------NFEDVDTREEAVELGQELMNEGLIEHVSGR 71
DEP_1_DEP6 cd04442
DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins ...
 30-88 7.05e-04

DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.


Pssm-ID: 239889 [Multi-domain]  Cd Length: 82  Bit Score: 39.11  E-value: 7.05e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 762205487  30 LRKHRQHLKKYSNCFTAVEAVDWLYDLLRSNSnfgpevtRQQTIQLLRKFLKNHVIEDI 88
Cdd:cd04442   15 IKDRRHHLRTYPNCFVGKELIDWLIEHKEASD-------RETAIKIMQKLLDHSIIHHV 66
DEP_Epac cd04437
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange ...
 29-107 1.31e-03

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by cyclic AMP, a second messenger that plays a role in the control of diverse cellular processes, such as cell adhesion and insulin secretion. Epac-like proteins share a common domain architecture, containing RasGEF, DEP and CAP-effector (cAMP binding) domains. The DEP domain is involved in membrane localization.


Pssm-ID: 239884  Cd Length: 125  Bit Score: 39.63  E-value: 1.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 762205487  29 PLRKHRQHLKKYSNCFTAVEAVDWLYDLlrsnsnfGPEV-TRQQTIQLLRKFLKNHVIEDIKGRWgseNLDDNNQLFRFP 107
Cdd:cd04437   16 LIRDRKYHLRTYRQCCVGTELVDWLLQQ-------SPCVqSRSQAVGMWQVLLEEGVLLHVDQEL---HFQDKYQFYRFS 85
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 253-304 1.79e-03

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 39.45  E-value: 1.79e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 762205487  253 KCLANWPRCNDTNSLTyvgferDVFKtiaDYFLDLPEPLLTFEYYELFVNIL 304
Cdd:pfam00620  42 PDVDLDLEEEDVHVVA------SLLK---LFLRELPEPLLTFELYEEFIEAA 84
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 263-324 6.05e-03

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 38.40  E-value: 6.05e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 762205487   263 DTNSLTyvgferDVFKTiadYFLDLPEPLLTFEYYELFVNILvvcgyiTVSDKTSGIHKIQD 324
Cdd:smart00324  55 DVHDVA------GLLKL---FLRELPEPLITYELYEEFIEAA------KLEDETERLRALRE 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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