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Conserved domains on  [gi|808356644|ref|NP_001293850|]
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Sulfatase domain-containing protein [Caenorhabditis elegans]

Protein Classification

alkaline phosphatase family protein( domain architecture ID 708218)

alkaline phosphatase family containing a DUF229 domain

PubMed:  1525473

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF229 super family cl27313
Protein of unknown function (DUF229); Members of this family are uncharacterized. They are ...
 1-223 3.60e-98

Protein of unknown function (DUF229); Members of this family are uncharacterized. They are 500-1200 amino acids in length and share a long region conservation that probably corresponds to several domains. The Go annotation for the protein indicates that it is involved in nematode larval development and has a positive regulation on growth rate.


The actual alignment was detected with superfamily member pfam02995:

Pssm-ID: 397236  Cd Length: 496  Bit Score: 298.49  E-value: 3.60e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356644    1 MWLQNGRQFMKKYEDVPRFLLMHQSLLSHDDINLVGVEDEDLSAHLSHMNDEGLFDDSVVIVMADHGHRFAKLRDTHQGQ 80
Cdd:pfam02995 276 YLLDYLRQFLPRYRDSPFFGFFWSNSLSHDDFNYASALDEDFLKYLKKLHKRGLLDNTIVIFMSDHGLRFGKLRRTSQGM 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356644   81 LEERMPFFSISLPKQLRntEKGRKMEQNLRENAEKLTSPFDIHASLMDILNLSELGENEL-NRMQDASSKRSLSVFKPIP 159
Cdd:pfam02995 356 LEERLPLMSIRYPPWFR--ETYPQAVENLELNANRLTTPFDLHATLKDILHLGELSDKELqDRMKALDCPRGISLFLPIP 433

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 808356644  160 VDRTCSQAGIEPHWCTCLSWKDAMDTgedRKLTRRIANAVVREINKEIVAEK--DLCAPLSLAKII 223
Cdd:pfam02995 434 DNRTCSDAGIPEHWCTCEPYKEVPTN---DTLVQRIARSVVERINEYLKTHNlsPLCAPLELQKVL 496
 
Name Accession Description Interval E-value
DUF229 pfam02995
Protein of unknown function (DUF229); Members of this family are uncharacterized. They are ...
 1-223 3.60e-98

Protein of unknown function (DUF229); Members of this family are uncharacterized. They are 500-1200 amino acids in length and share a long region conservation that probably corresponds to several domains. The Go annotation for the protein indicates that it is involved in nematode larval development and has a positive regulation on growth rate.


Pssm-ID: 397236  Cd Length: 496  Bit Score: 298.49  E-value: 3.60e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356644    1 MWLQNGRQFMKKYEDVPRFLLMHQSLLSHDDINLVGVEDEDLSAHLSHMNDEGLFDDSVVIVMADHGHRFAKLRDTHQGQ 80
Cdd:pfam02995 276 YLLDYLRQFLPRYRDSPFFGFFWSNSLSHDDFNYASALDEDFLKYLKKLHKRGLLDNTIVIFMSDHGLRFGKLRRTSQGM 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356644   81 LEERMPFFSISLPKQLRntEKGRKMEQNLRENAEKLTSPFDIHASLMDILNLSELGENEL-NRMQDASSKRSLSVFKPIP 159
Cdd:pfam02995 356 LEERLPLMSIRYPPWFR--ETYPQAVENLELNANRLTTPFDLHATLKDILHLGELSDKELqDRMKALDCPRGISLFLPIP 433

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 808356644  160 VDRTCSQAGIEPHWCTCLSWKDAMDTgedRKLTRRIANAVVREINKEIVAEK--DLCAPLSLAKII 223
Cdd:pfam02995 434 DNRTCSDAGIPEHWCTCEPYKEVPTN---DTLVQRIARSVVERINEYLKTHNlsPLCAPLELQKVL 496
ALP_like cd16021
uncharacterized Alkaline phosphatase subfamily; Alkaline phosphatases are non-specific ...
 7-133 3.82e-55

uncharacterized Alkaline phosphatase subfamily; Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity.


Pssm-ID: 293745  Cd Length: 278  Bit Score: 180.79  E-value: 3.82e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356644   7 RQFMKKYEDVPRFLLMHQSLLSHDDINLVGVEDEDLSAHLSHMNDEGLFDDSVVIVMADHGHRFAKLRDTHQGQLEERMP 86
Cdd:cd16021  154 EDFIEAYKDRPKFSFFWLSELTHDYLNGLSLADEDLLEFLKRLKENGLLDNTFVIFMSDHGLRFGKIRETLQGKLEERLP 233

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 808356644  87 FFSISLPKQLRNTEKGrkMEQNLRENAEKLTSPFDIHASLMDILNLS 133
Cdd:cd16021  234 FLSISLPKWFREKYPE--AVANLKKNSNRLTTPFDLHATLLDILNLQ 278
MdoB COG1368
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope ...
 52-141 1.52e-05

Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440979 [Multi-domain]  Cd Length: 576  Bit Score: 46.57  E-value: 1.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356644  52 EGLFDDSVVIVMADHGHRFAKLRDTHQGQLEERMPFFsISLPKQlrntEKGRKMeqnlrenaEKLTSPFDIHASLMDILN 131
Cdd:COG1368  440 SGWYDNTIFVIYGDHGPRSPGKTDYENPLERYRVPLL-IYSPGL----KKPKVI--------DTVGSQIDIAPTLLDLLG 506

                         90
                 ....*....|....*
gi 808356644 132 LSE-----LGENELN 141
Cdd:COG1368  507 IDYpsyyaFGRDLLS 521
 
Name Accession Description Interval E-value
DUF229 pfam02995
Protein of unknown function (DUF229); Members of this family are uncharacterized. They are ...
 1-223 3.60e-98

Protein of unknown function (DUF229); Members of this family are uncharacterized. They are 500-1200 amino acids in length and share a long region conservation that probably corresponds to several domains. The Go annotation for the protein indicates that it is involved in nematode larval development and has a positive regulation on growth rate.


Pssm-ID: 397236  Cd Length: 496  Bit Score: 298.49  E-value: 3.60e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356644    1 MWLQNGRQFMKKYEDVPRFLLMHQSLLSHDDINLVGVEDEDLSAHLSHMNDEGLFDDSVVIVMADHGHRFAKLRDTHQGQ 80
Cdd:pfam02995 276 YLLDYLRQFLPRYRDSPFFGFFWSNSLSHDDFNYASALDEDFLKYLKKLHKRGLLDNTIVIFMSDHGLRFGKLRRTSQGM 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356644   81 LEERMPFFSISLPKQLRntEKGRKMEQNLRENAEKLTSPFDIHASLMDILNLSELGENEL-NRMQDASSKRSLSVFKPIP 159
Cdd:pfam02995 356 LEERLPLMSIRYPPWFR--ETYPQAVENLELNANRLTTPFDLHATLKDILHLGELSDKELqDRMKALDCPRGISLFLPIP 433

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 808356644  160 VDRTCSQAGIEPHWCTCLSWKDAMDTgedRKLTRRIANAVVREINKEIVAEK--DLCAPLSLAKII 223
Cdd:pfam02995 434 DNRTCSDAGIPEHWCTCEPYKEVPTN---DTLVQRIARSVVERINEYLKTHNlsPLCAPLELQKVL 496
ALP_like cd16021
uncharacterized Alkaline phosphatase subfamily; Alkaline phosphatases are non-specific ...
 7-133 3.82e-55

uncharacterized Alkaline phosphatase subfamily; Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity.


Pssm-ID: 293745  Cd Length: 278  Bit Score: 180.79  E-value: 3.82e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356644   7 RQFMKKYEDVPRFLLMHQSLLSHDDINLVGVEDEDLSAHLSHMNDEGLFDDSVVIVMADHGHRFAKLRDTHQGQLEERMP 86
Cdd:cd16021  154 EDFIEAYKDRPKFSFFWLSELTHDYLNGLSLADEDLLEFLKRLKENGLLDNTFVIFMSDHGLRFGKIRETLQGKLEERLP 233

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 808356644  87 FFSISLPKQLRNTEKGrkMEQNLRENAEKLTSPFDIHASLMDILNLS 133
Cdd:cd16021  234 FLSISLPKWFREKYPE--AVANLKKNSNRLTTPFDLHATLLDILNLQ 278
MdoB COG1368
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope ...
 52-141 1.52e-05

Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440979 [Multi-domain]  Cd Length: 576  Bit Score: 46.57  E-value: 1.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356644  52 EGLFDDSVVIVMADHGHRFAKLRDTHQGQLEERMPFFsISLPKQlrntEKGRKMeqnlrenaEKLTSPFDIHASLMDILN 131
Cdd:COG1368  440 SGWYDNTIFVIYGDHGPRSPGKTDYENPLERYRVPLL-IYSPGL----KKPKVI--------DTVGSQIDIAPTLLDLLG 506

                         90
                 ....*....|....*
gi 808356644 132 LSE-----LGENELN 141
Cdd:COG1368  507 IDYpsyyaFGRDLLS 521
sulfatase_like cd16148
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ...
 46-132 7.52e-05

uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293767 [Multi-domain]  Cd Length: 271  Bit Score: 43.69  E-value: 7.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356644  46 LSHMNDEGLFDDSVVIVMADHGHRFA--KLRDTHQGQL-EE--RMPFFsISLPKQlrntEKGRKMEQnlrenaekLTSPF 120
Cdd:cd16148  180 LDKLKELGLLEDTLVIVTSDHGEEFGehGLYWGHGSNLyDEqlHVPLI-IRWPGK----EPGKRVDA--------LVSHI 246

                         90
                 ....*....|..
gi 808356644 121 DIHASLMDILNL 132
Cdd:cd16148  247 DIAPTLLDLLGV 258
ALP_like cd00016
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and ...
 50-130 1.74e-03

alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and sulfatases. Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. Both alkaline phosphatase and sulfatase are essential for human metabolism. Deficiency of individual enzyme cause genetic diseases.


Pssm-ID: 293732 [Multi-domain]  Cd Length: 237  Bit Score: 39.33  E-value: 1.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356644  50 NDEGLFDDSVVIVMADHGHRFAKLR-----DTHQGQ--LEERMPFFSISlpkqlrnteKGRKMEQNLREnaekLTSPFDI 122
Cdd:cd00016  163 KKAGDADDTVIIVTADHGGIDKGHGgdpkaDGKADKshTGMRVPFIAYG---------PGVKKGGVKHE----LISQYDI 229


                 ....*...
gi 808356644 123 HASLMDIL 130
Cdd:cd00016  230 APTLADLL 237
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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