RWD domain-containing protein 4 isoform 2 [Homo sapiens]
Protein Classification
RWD domain-containing protein( domain architecture ID 5491)
RWD domain-containing protein similar to Homo sapiens RWD domain-containing protein 3 (RWDD3), also known as RSUME, which is a RWD-containing protein that enhances SUMO conjugation by interacting with the SUMO conjugase Ubc9, increases Ubc9 thioester formation and therefore favours sumoylation of specific targets
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| RWD_DRWD_ELF-like super family | cl45901 | RWD, DRWD, and ELF domain family; The family includes the RWD, double-RWD (DRWD), and ELF ... |
1-48 | 4.03e-23 | ||
RWD, DRWD, and ELF domain family; The family includes the RWD, double-RWD (DRWD), and ELF domains. They belong to the ubiquitin-conjugating (UBC) superfamily that represents a structural domain with an alpha-beta(4)-alpha(3) core fold. The RWD domain (named after three major RWD-containing proteins: RING finger, WD-repeat-containing proteins and DEXD-like helicases) mediates protein-protein interactions in a variety of pathways in eukaryotes. The DRWD domain is responsible for substrate binding. It is involved in interactions with other kinetochore proteins. The ELF (N-terminal E2-like fold) domain is found in all Fanconi anemia group L protein (FANCL) homologs. It is required to promote efficient DNA damage-induced FANCD2 (Fanconi anemia group D2 protein) monoubiquitination in vertebrate cells. The actual alignment was detected with superfamily member cd23817: Pssm-ID: 480265 Cd Length: 104 Bit Score: 86.03 E-value: 4.03e-23
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| Name | Accession | Description | Interval | E-value | ||
| RWD-RWDD4 | cd23817 | RWD domain of RWD domain-containing protein 4 (RWDD4) and related proteins; RWDD4, also called ... |
1-48 | 4.03e-23 | ||
RWD domain of RWD domain-containing protein 4 (RWDD4) and related proteins; RWDD4, also called protein FAM28A, is a target of the tumor suppressor MicroRNA (MiR)-506 in bladder cancer cells. Downregulation of RWDD4 suppresses bladder cancer cell proliferation, migration and invasion. RWDD4 has also been identified as a modifier of metastasis in human prostate cancer. Pssm-ID: 467653 Cd Length: 104 Bit Score: 86.03 E-value: 4.03e-23
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| RWD | pfam05773 | RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. ... |
6-44 | 9.35e-04 | ||
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices. Pssm-ID: 399058 Cd Length: 111 Bit Score: 36.15 E-value: 9.35e-04
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| Name | Accession | Description | Interval | E-value | ||
| RWD-RWDD4 | cd23817 | RWD domain of RWD domain-containing protein 4 (RWDD4) and related proteins; RWDD4, also called ... |
1-48 | 4.03e-23 | ||
RWD domain of RWD domain-containing protein 4 (RWDD4) and related proteins; RWDD4, also called protein FAM28A, is a target of the tumor suppressor MicroRNA (MiR)-506 in bladder cancer cells. Downregulation of RWDD4 suppresses bladder cancer cell proliferation, migration and invasion. RWDD4 has also been identified as a modifier of metastasis in human prostate cancer. Pssm-ID: 467653 Cd Length: 104 Bit Score: 86.03 E-value: 4.03e-23
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| RWD | pfam05773 | RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. ... |
6-44 | 9.35e-04 | ||
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices. Pssm-ID: 399058 Cd Length: 111 Bit Score: 36.15 E-value: 9.35e-04
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| RWD_RNF25 | cd23818 | RWD domain of RING finger protein 25 (RNF25) and related proteins; RNF25 (EC 2.3.2.27), also ... |
9-43 | 3.64e-03 | ||
RWD domain of RING finger protein 25 (RNF25) and related proteins; RNF25 (EC 2.3.2.27), also known as AO7, is a putative E3 ubiquitin-protein ligase that was initially identified as an interacting protein of the E2 ubiquitin-conjugating enzyme, Ubc5B. It is ubiquitously expressed in various tissues and is predominantly localized in the nucleus. RNF25 activates nuclear factor (NF)-kappaB-dependent gene expression upon stimulation with interleukin-1 beta (IL-1beta), or tumor necrosis factor (TNF), or overexpression of NF-kappaB-inducing kinase. It interacts with the p65 transactivation domain (TAD) and modulates its transcriptional activity. Pssm-ID: 467654 Cd Length: 109 Bit Score: 34.44 E-value: 3.64e-03
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