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Conserved domains on  [gi|808154218|ref|NP_001294858|]
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eukaryotic translation initiation factor 3 subunit M isoform 2 [Homo sapiens]

Protein Classification

PCI domain-containing protein( domain architecture ID 12188609)

PCI (proteasome-COP9/CSN-initiation factor) domain-containing protein is a component of multiprotein complexes; similar to eukaryotic translation initiation factor 3 subunits A and M, and Schizosaccharomyces pombe Cop9 signalosome complex subunit 4

Gene Ontology:  GO:0032991|GO:0032991
PubMed:  9644972|36094910|19683491|11495792
SCOP:  4000147

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
 137-225 9.39e-19

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


:

Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 78.05  E-value: 9.39e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154218   137 LHEQNMAKMRLLTFMGMAVENKEISFDTMQQELQIGADDVEAFVIDAVRTKMVYCKIDQTQRKVVVSHSTHRTfgKQQWQ 216
Cdd:smart00088   2 LVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVPEVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPRR--SEPLA 79


                   ....*....
gi 808154218   217 QLYDTLNAW 225
Cdd:smart00088  80 QFAETLKKL 88
 
Name Accession Description Interval E-value
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
 137-225 9.39e-19

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 78.05  E-value: 9.39e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154218   137 LHEQNMAKMRLLTFMGMAVENKEISFDTMQQELQIGADDVEAFVIDAVRTKMVYCKIDQTQRKVVVSHSTHRTfgKQQWQ 216
Cdd:smart00088   2 LVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVPEVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPRR--SEPLA 79


                   ....*....
gi 808154218   217 QLYDTLNAW 225
Cdd:smart00088  80 QFAETLKKL 88
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
 105-204 5.74e-16

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 71.09  E-value: 5.74e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154218  105 IHDLLTIFVSAKLASYVKFYQNNKDFI---DSLGLLHEQNMAKMRLLTFMGMAVENKEISFDTMQQELQIGADDVEAFVI 181
Cdd:pfam01399   3 YRDLLRAFYSGDLSEFEEILADYKEELlldDGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLSVDEVEKILA 82

                          90       100
                  ....*....|....*....|...
gi 808154218  182 DAVRTKMVYCKIDQTQRKVVVSH 204
Cdd:pfam01399  83 KLIRDGRIRAKIDQVNGIVVFSK 105
 
Name Accession Description Interval E-value
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
 137-225 9.39e-19

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 78.05  E-value: 9.39e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154218   137 LHEQNMAKMRLLTFMGMAVENKEISFDTMQQELQIGADDVEAFVIDAVRTKMVYCKIDQTQRKVVVSHSTHRTfgKQQWQ 216
Cdd:smart00088   2 LVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVPEVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPRR--SEPLA 79


                   ....*....
gi 808154218   217 QLYDTLNAW 225
Cdd:smart00088  80 QFAETLKKL 88
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
 105-204 5.74e-16

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 71.09  E-value: 5.74e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808154218  105 IHDLLTIFVSAKLASYVKFYQNNKDFI---DSLGLLHEQNMAKMRLLTFMGMAVENKEISFDTMQQELQIGADDVEAFVI 181
Cdd:pfam01399   3 YRDLLRAFYSGDLSEFEEILADYKEELlldDGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLSVDEVEKILA 82

                          90       100
                  ....*....|....*....|...
gi 808154218  182 DAVRTKMVYCKIDQTQRKVVVSH 204
Cdd:pfam01399  83 KLIRDGRIRAKIDQVNGIVVFSK 105
eIF3m_C_helix pfam18005
eIF3 subunit M, C-terminal helix; This is the C-terminal helix domain found in Eukaryotic ...
 208-236 2.01e-09

eIF3 subunit M, C-terminal helix; This is the C-terminal helix domain found in Eukaryotic translation initiation factor 3 subunit M (eIF3m). In mammalian eIF3a, the C-terminal helix following the PCI domain is involved in interactions with other core subunits.


Pssm-ID: 465614  Cd Length: 29  Bit Score: 51.32  E-value: 2.01e-09
                          10        20
                  ....*....|....*....|....*....
gi 808154218  208 RTFGKQQWQQLYDTLNAWKQNLNKVKNSL 236
Cdd:pfam18005   1 RVFGKEQWQELRSRLDAWKSNLANVLEVI 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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