|
Name |
Accession |
Description |
Interval |
E-value |
| Treslin_N |
pfam15292 |
Treslin N-terminus; This family represents the N-terminus of treslin, a checkpoint regulator ... |
208-1003 |
0e+00 |
|
Treslin N-terminus; This family represents the N-terminus of treslin, a checkpoint regulator which plays a role in DNA replication preinitiation complex formation.
:
Pssm-ID: 464618 Cd Length: 793 Bit Score: 1385.55 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 208 FYWVDTTEWSKLWESPDHLGYWTVCELLHHGGGTVLPSESFSWDFAQAGEMLLRSGIKLSSEPHLSPWISMLPTDATLNR 287
Cdd:pfam15292 1 LHWVDTTEYSKLWESPDHLGYWTVSEVLQQVGGTILPSETALLDLSSAGESLLSGGRKGSPAPHLSPWISALPFDSTLNY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 288 LLYNSPEYEASFPRMEGMLFLPVEGKEIQETWTVTLEPLAMHQRHFQKPVRIFLKGSVAQWSLPTSSTLGTDSWMLGSPE 367
Cdd:pfam15292 81 LLSSEPVYRAAFPQLEGVLFWPQEGKEEQQSCAVTLEPVAMRQRHLQEPVRIFLKGVLTQWDAPSLSQLGTESWILQSSE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 368 ESTATQRLLFQQLVSRLTAEELHLVADVDPGEGRPPITGVISPLSASAMILTVCRTKEAEFQRHVLQTAVADSPRDTASL 447
Cdd:pfam15292 161 EEDSEQAALFQQLLRRLSAEELHMVAEVDPGEGGPPCTAVLSPLSASTALLTVLQPEEAQFQQLLLTTVVTESTQDTSSD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 448 FSDVVDSILNQTHDSLADTASA----ASPVPEWAQQELGHTTPWSPAVVEKWFPFCNISGASSDLMESFGLLQAASANKE 523
Cdd:pfam15292 241 LPDVVSSVLNVVYDIMEEDPAAdeieDPPVPEWAQQELSRTSPWSTAVVEGWFPLSDQSGASSHLMESFRLLQAVPEEKE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 524 ESSKT-EGELIHCLAELYQRKSREEStiAHQEDSKKKRGVPRTPVRQKMNTMCRSLKMLNVARLNVKAQKLHPDGSPDVA 602
Cdd:pfam15292 321 ESSKTlEQELTSCLSELYQRKSREES--ASQEDRGKKRGVPRTPVRQKMKTMSRSLQMLNVARLNVKAQKLQPEGEPDGA 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 603 GEKGIQKIPSGRTVDKLEDRGRTLRSskPKDFKTEEELLSYIRENYQKTVATGEIMLYACARNMISTVKMFLKSKGTkEL 682
Cdd:pfam15292 399 GEKGPQKPGKRRSSDRLEPRGRTLRS--PKDFKTEEELLSHLKENYQKTVAEGESSLLTCAQNLISTVKAFLKSKGT-DL 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 683 EVNCLNQVKSSLLKTSKSLRQNLGKKLDKEDKVRECQLQVFLRLEMCLQCPSINESTDDMEQVVEEVTDLLRMVCLTEDS 762
Cdd:pfam15292 476 EANCLNLVKNHLLKTSKSIRQQYGSALDKESKVRECQLQVFLRLELCLQCPSLQSDSDDMEQLVEEVTDMLRIISLTKDP 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 763 AYLAEFL-EEILRLYIDSIPKTLGNLYNSLGFVIPQKLAGVLPTDFFSDDSMTQENKSPLLSVPFLSSARRSVSGspeSD 841
Cdd:pfam15292 556 AYLARFLqEEILPLYLDSIPKTLGDLYHSLGTQIPEKLAAVLPADFFSDDSMTQDSISPSLSSSLLSSASLSSSG---ED 632
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 842 ELQELRTRSAKKRRKNALIRHKSIAEVSQNLRQIEIPKVSKRATKKENSHPAPQQPSQ---PVKDTVQEVTKVRRNLFNQ 918
Cdd:pfam15292 633 QLEELRTRSAKKRRKNALTRHRSMTESSQNLRQIEIPKKSKRATKSENSHSLLKTAVQqppPQKDTVQEVTKVRRNLFNQ 712
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 919 ELLSPSKRSLkrgLPRSHSVSAVDGLEDKLDNFKKNkGYHKLLTKSVAETPVHKQISKRLLHRQIKGRSSDPGPDIGVVE 998
Cdd:pfam15292 713 EIVSPSKRSK---LPRSQSVSAVEGLKHKRSSEKEE-DYHKLLTKKVAETPLHKQVSRRLLHRQIKGRSSDPGPDICIVE 788
|
....*
gi 808688280 999 ESPEK 1003
Cdd:pfam15292 789 ESPEK 793
|
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
1085-1503 |
1.01e-06 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.17 E-value: 1.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1085 RMKKRSRNTLDSEVPAAYQTPKKSHQKSLSfSKTTPRRISHTPQTPLYTPERLQKSPAKMTPTKQAAFKESLKDSSSPGH 1164
Cdd:PHA03247 2660 RVSRPRRARRLGRAAQASSPPQRPRRRAAR-PTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAA 2738
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1165 DSPLDSKITPQKRHTQAGEGTSLETKTPRTPKRQGTQPPGFLPNCTWPHSVNSSPESPSCPAPPTSSTAqprrecltpir 1244
Cdd:PHA03247 2739 PAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP----------- 2807
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1245 dPLRTPPRAAAF--MGTPQNQTHQQPHVLRAARAEEPAQKLKDKAIKTPKRPGNSTVTSSPPVTPKKLFTSPlcdvsKKS 1322
Cdd:PHA03247 2808 -PAAVLAPAAALppAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAP-----ARP 2881
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1323 PFRKSKIECPSPGELDQKEPQMSPSVAASLSCPVPSTPPELSQRATLDTVPPPPPSkvgkrcrktsdprrsivecQPDAS 1402
Cdd:PHA03247 2882 PVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPP-------------------RPQPP 2942
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1403 ATPGVGTADSPAAPTDSRDDQKGL----------SLSPQ----------SPPERRGYPGPGLrSDWHASSPLLITSDTEH 1462
Cdd:PHA03247 2943 LAPTTDPAGAGEPSGAVPQPWLGAlvpgrvavprFRVPQpapsreapasSTPPLTGHSLSRV-SSWASSLALHEETDPPP 3021
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 808688280 1463 VTLL------SEAEHhgiGDLKSNVLSVEEGEGLRTADAEKSSLSHP 1503
Cdd:PHA03247 3022 VSLKqtlwppDDTED---SDADSLFDSDSERSDLEALDPLPPEPHDP 3065
|
|
| PHA03307 super family |
cl33723 |
transcriptional regulator ICP4; Provisional |
1322-1706 |
1.41e-03 |
|
transcriptional regulator ICP4; Provisional
The actual alignment was detected with superfamily member PHA03307:
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 43.62 E-value: 1.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1322 SPFRKSKIECPSPGELDQKEPQMSPSVAASLSCPVPSTPPELSQRATLDTVPPPPPSkvgkrcrkTSDPrrsiveCQPDA 1401
Cdd:PHA03307 63 DRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPP--------TPPP------ASPPP 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1402 SATPGVGTADSPAAPTDSRDDQkglslSPQSPPERRGYPGPGLRSDWHASSPLLITSDTEHVtllseaehhGIGDLKSNV 1481
Cdd:PHA03307 129 SPAPDLSEMLRPVGSPGPPPAA-----SPPAAGASPAAVASDAASSRQAALPLSSPEETARA---------PSSPPAEPP 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1482 LSVEEGEGLRTADAEKSSLSHPGIPPSPpscgpgsplMPSRDvhcttdgrqcqasaQLDNLPASAWHSTDSASPQTYEVE 1561
Cdd:PHA03307 195 PSTPPAAASPRPPRRSSPISASASSPAP---------APGRS--------------AADDAGASSSDSSSSESSGCGWGP 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1562 LEMQASGLPKLrikKIDPSSSLEAEPLSKEESSLGEESFLPALSMPRASRSLSKPEPTYVSPPCPRLSHSTP------GK 1635
Cdd:PHA03307 252 ENECPLPRPAP---ITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSsresssSS 328
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 808688280 1636 SRGQTYICQACTPTHGPSSTPSPFQTDGVPWTP-------SPKHSGKTTPDIIKDWPRRKRAVGCGAGSSSGRGEVGA 1706
Cdd:PHA03307 329 TSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADpssprkrPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGR 406
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Treslin_N |
pfam15292 |
Treslin N-terminus; This family represents the N-terminus of treslin, a checkpoint regulator ... |
208-1003 |
0e+00 |
|
Treslin N-terminus; This family represents the N-terminus of treslin, a checkpoint regulator which plays a role in DNA replication preinitiation complex formation.
Pssm-ID: 464618 Cd Length: 793 Bit Score: 1385.55 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 208 FYWVDTTEWSKLWESPDHLGYWTVCELLHHGGGTVLPSESFSWDFAQAGEMLLRSGIKLSSEPHLSPWISMLPTDATLNR 287
Cdd:pfam15292 1 LHWVDTTEYSKLWESPDHLGYWTVSEVLQQVGGTILPSETALLDLSSAGESLLSGGRKGSPAPHLSPWISALPFDSTLNY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 288 LLYNSPEYEASFPRMEGMLFLPVEGKEIQETWTVTLEPLAMHQRHFQKPVRIFLKGSVAQWSLPTSSTLGTDSWMLGSPE 367
Cdd:pfam15292 81 LLSSEPVYRAAFPQLEGVLFWPQEGKEEQQSCAVTLEPVAMRQRHLQEPVRIFLKGVLTQWDAPSLSQLGTESWILQSSE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 368 ESTATQRLLFQQLVSRLTAEELHLVADVDPGEGRPPITGVISPLSASAMILTVCRTKEAEFQRHVLQTAVADSPRDTASL 447
Cdd:pfam15292 161 EEDSEQAALFQQLLRRLSAEELHMVAEVDPGEGGPPCTAVLSPLSASTALLTVLQPEEAQFQQLLLTTVVTESTQDTSSD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 448 FSDVVDSILNQTHDSLADTASA----ASPVPEWAQQELGHTTPWSPAVVEKWFPFCNISGASSDLMESFGLLQAASANKE 523
Cdd:pfam15292 241 LPDVVSSVLNVVYDIMEEDPAAdeieDPPVPEWAQQELSRTSPWSTAVVEGWFPLSDQSGASSHLMESFRLLQAVPEEKE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 524 ESSKT-EGELIHCLAELYQRKSREEStiAHQEDSKKKRGVPRTPVRQKMNTMCRSLKMLNVARLNVKAQKLHPDGSPDVA 602
Cdd:pfam15292 321 ESSKTlEQELTSCLSELYQRKSREES--ASQEDRGKKRGVPRTPVRQKMKTMSRSLQMLNVARLNVKAQKLQPEGEPDGA 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 603 GEKGIQKIPSGRTVDKLEDRGRTLRSskPKDFKTEEELLSYIRENYQKTVATGEIMLYACARNMISTVKMFLKSKGTkEL 682
Cdd:pfam15292 399 GEKGPQKPGKRRSSDRLEPRGRTLRS--PKDFKTEEELLSHLKENYQKTVAEGESSLLTCAQNLISTVKAFLKSKGT-DL 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 683 EVNCLNQVKSSLLKTSKSLRQNLGKKLDKEDKVRECQLQVFLRLEMCLQCPSINESTDDMEQVVEEVTDLLRMVCLTEDS 762
Cdd:pfam15292 476 EANCLNLVKNHLLKTSKSIRQQYGSALDKESKVRECQLQVFLRLELCLQCPSLQSDSDDMEQLVEEVTDMLRIISLTKDP 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 763 AYLAEFL-EEILRLYIDSIPKTLGNLYNSLGFVIPQKLAGVLPTDFFSDDSMTQENKSPLLSVPFLSSARRSVSGspeSD 841
Cdd:pfam15292 556 AYLARFLqEEILPLYLDSIPKTLGDLYHSLGTQIPEKLAAVLPADFFSDDSMTQDSISPSLSSSLLSSASLSSSG---ED 632
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 842 ELQELRTRSAKKRRKNALIRHKSIAEVSQNLRQIEIPKVSKRATKKENSHPAPQQPSQ---PVKDTVQEVTKVRRNLFNQ 918
Cdd:pfam15292 633 QLEELRTRSAKKRRKNALTRHRSMTESSQNLRQIEIPKKSKRATKSENSHSLLKTAVQqppPQKDTVQEVTKVRRNLFNQ 712
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 919 ELLSPSKRSLkrgLPRSHSVSAVDGLEDKLDNFKKNkGYHKLLTKSVAETPVHKQISKRLLHRQIKGRSSDPGPDIGVVE 998
Cdd:pfam15292 713 EIVSPSKRSK---LPRSQSVSAVEGLKHKRSSEKEE-DYHKLLTKKVAETPLHKQVSRRLLHRQIKGRSSDPGPDICIVE 788
|
....*
gi 808688280 999 ESPEK 1003
Cdd:pfam15292 789 ESPEK 793
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1085-1503 |
1.01e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.17 E-value: 1.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1085 RMKKRSRNTLDSEVPAAYQTPKKSHQKSLSfSKTTPRRISHTPQTPLYTPERLQKSPAKMTPTKQAAFKESLKDSSSPGH 1164
Cdd:PHA03247 2660 RVSRPRRARRLGRAAQASSPPQRPRRRAAR-PTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAA 2738
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1165 DSPLDSKITPQKRHTQAGEGTSLETKTPRTPKRQGTQPPGFLPNCTWPHSVNSSPESPSCPAPPTSSTAqprrecltpir 1244
Cdd:PHA03247 2739 PAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP----------- 2807
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1245 dPLRTPPRAAAF--MGTPQNQTHQQPHVLRAARAEEPAQKLKDKAIKTPKRPGNSTVTSSPPVTPKKLFTSPlcdvsKKS 1322
Cdd:PHA03247 2808 -PAAVLAPAAALppAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAP-----ARP 2881
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1323 PFRKSKIECPSPGELDQKEPQMSPSVAASLSCPVPSTPPELSQRATLDTVPPPPPSkvgkrcrktsdprrsivecQPDAS 1402
Cdd:PHA03247 2882 PVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPP-------------------RPQPP 2942
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1403 ATPGVGTADSPAAPTDSRDDQKGL----------SLSPQ----------SPPERRGYPGPGLrSDWHASSPLLITSDTEH 1462
Cdd:PHA03247 2943 LAPTTDPAGAGEPSGAVPQPWLGAlvpgrvavprFRVPQpapsreapasSTPPLTGHSLSRV-SSWASSLALHEETDPPP 3021
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 808688280 1463 VTLL------SEAEHhgiGDLKSNVLSVEEGEGLRTADAEKSSLSHP 1503
Cdd:PHA03247 3022 VSLKqtlwppDDTED---SDADSLFDSDSERSDLEALDPLPPEPHDP 3065
|
|
| GGN |
pfam15685 |
Gametogenetin; GGN is a family of proteins largely found in mammals. It reacts with POG in the ... |
1334-1501 |
4.40e-04 |
|
Gametogenetin; GGN is a family of proteins largely found in mammals. It reacts with POG in the maturation of sperm and is expressed virtually only in the testis. It is found to be associated with the intracellular membrane, binds with GGNBP1 and may be involved in vesicular trafficking.
Pssm-ID: 434857 [Multi-domain] Cd Length: 668 Bit Score: 45.14 E-value: 4.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1334 PGELDQKEPQMSPS-VAASLSCPVPST-PPELSQRATLDTVPPPP-------PSKvGKRCRKTSDPR-RSIVECQPDASA 1403
Cdd:pfam15685 59 PGLLVPPEPQASPSpLPLTLELPLPVTpPPEEAAAAAVSTAPPPAvgsllpaPSK-WRKPTGTAVARiRGLLEASHRGQG 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1404 TPGVGTADSPAAPTD--SRDDQKGLSLSPQSPPERRGYPGPGLRSDWHASS----PLLITSDTEHVTllSEAEHHGIGDL 1477
Cdd:pfam15685 138 DPLSLRPLLPLLPRQliEKDPAPGAPAPPPPTPLEPRKPPPLPPSDRQPPNrgitPALATSATSPTD--SQAKHIAEGKT 215
|
170 180
....*....|....*....|....*....
gi 808688280 1478 KSNVL-----SVEEGEGLRTAdAEKSSLS 1501
Cdd:pfam15685 216 AGGACggappQAGEGEMARFA-ASESGLS 243
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
1322-1706 |
1.41e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 43.62 E-value: 1.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1322 SPFRKSKIECPSPGELDQKEPQMSPSVAASLSCPVPSTPPELSQRATLDTVPPPPPSkvgkrcrkTSDPrrsiveCQPDA 1401
Cdd:PHA03307 63 DRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPP--------TPPP------ASPPP 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1402 SATPGVGTADSPAAPTDSRDDQkglslSPQSPPERRGYPGPGLRSDWHASSPLLITSDTEHVtllseaehhGIGDLKSNV 1481
Cdd:PHA03307 129 SPAPDLSEMLRPVGSPGPPPAA-----SPPAAGASPAAVASDAASSRQAALPLSSPEETARA---------PSSPPAEPP 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1482 LSVEEGEGLRTADAEKSSLSHPGIPPSPpscgpgsplMPSRDvhcttdgrqcqasaQLDNLPASAWHSTDSASPQTYEVE 1561
Cdd:PHA03307 195 PSTPPAAASPRPPRRSSPISASASSPAP---------APGRS--------------AADDAGASSSDSSSSESSGCGWGP 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1562 LEMQASGLPKLrikKIDPSSSLEAEPLSKEESSLGEESFLPALSMPRASRSLSKPEPTYVSPPCPRLSHSTP------GK 1635
Cdd:PHA03307 252 ENECPLPRPAP---ITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSsresssSS 328
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 808688280 1636 SRGQTYICQACTPTHGPSSTPSPFQTDGVPWTP-------SPKHSGKTTPDIIKDWPRRKRAVGCGAGSSSGRGEVGA 1706
Cdd:PHA03307 329 TSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADpssprkrPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGR 406
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Treslin_N |
pfam15292 |
Treslin N-terminus; This family represents the N-terminus of treslin, a checkpoint regulator ... |
208-1003 |
0e+00 |
|
Treslin N-terminus; This family represents the N-terminus of treslin, a checkpoint regulator which plays a role in DNA replication preinitiation complex formation.
Pssm-ID: 464618 Cd Length: 793 Bit Score: 1385.55 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 208 FYWVDTTEWSKLWESPDHLGYWTVCELLHHGGGTVLPSESFSWDFAQAGEMLLRSGIKLSSEPHLSPWISMLPTDATLNR 287
Cdd:pfam15292 1 LHWVDTTEYSKLWESPDHLGYWTVSEVLQQVGGTILPSETALLDLSSAGESLLSGGRKGSPAPHLSPWISALPFDSTLNY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 288 LLYNSPEYEASFPRMEGMLFLPVEGKEIQETWTVTLEPLAMHQRHFQKPVRIFLKGSVAQWSLPTSSTLGTDSWMLGSPE 367
Cdd:pfam15292 81 LLSSEPVYRAAFPQLEGVLFWPQEGKEEQQSCAVTLEPVAMRQRHLQEPVRIFLKGVLTQWDAPSLSQLGTESWILQSSE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 368 ESTATQRLLFQQLVSRLTAEELHLVADVDPGEGRPPITGVISPLSASAMILTVCRTKEAEFQRHVLQTAVADSPRDTASL 447
Cdd:pfam15292 161 EEDSEQAALFQQLLRRLSAEELHMVAEVDPGEGGPPCTAVLSPLSASTALLTVLQPEEAQFQQLLLTTVVTESTQDTSSD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 448 FSDVVDSILNQTHDSLADTASA----ASPVPEWAQQELGHTTPWSPAVVEKWFPFCNISGASSDLMESFGLLQAASANKE 523
Cdd:pfam15292 241 LPDVVSSVLNVVYDIMEEDPAAdeieDPPVPEWAQQELSRTSPWSTAVVEGWFPLSDQSGASSHLMESFRLLQAVPEEKE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 524 ESSKT-EGELIHCLAELYQRKSREEStiAHQEDSKKKRGVPRTPVRQKMNTMCRSLKMLNVARLNVKAQKLHPDGSPDVA 602
Cdd:pfam15292 321 ESSKTlEQELTSCLSELYQRKSREES--ASQEDRGKKRGVPRTPVRQKMKTMSRSLQMLNVARLNVKAQKLQPEGEPDGA 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 603 GEKGIQKIPSGRTVDKLEDRGRTLRSskPKDFKTEEELLSYIRENYQKTVATGEIMLYACARNMISTVKMFLKSKGTkEL 682
Cdd:pfam15292 399 GEKGPQKPGKRRSSDRLEPRGRTLRS--PKDFKTEEELLSHLKENYQKTVAEGESSLLTCAQNLISTVKAFLKSKGT-DL 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 683 EVNCLNQVKSSLLKTSKSLRQNLGKKLDKEDKVRECQLQVFLRLEMCLQCPSINESTDDMEQVVEEVTDLLRMVCLTEDS 762
Cdd:pfam15292 476 EANCLNLVKNHLLKTSKSIRQQYGSALDKESKVRECQLQVFLRLELCLQCPSLQSDSDDMEQLVEEVTDMLRIISLTKDP 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 763 AYLAEFL-EEILRLYIDSIPKTLGNLYNSLGFVIPQKLAGVLPTDFFSDDSMTQENKSPLLSVPFLSSARRSVSGspeSD 841
Cdd:pfam15292 556 AYLARFLqEEILPLYLDSIPKTLGDLYHSLGTQIPEKLAAVLPADFFSDDSMTQDSISPSLSSSLLSSASLSSSG---ED 632
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 842 ELQELRTRSAKKRRKNALIRHKSIAEVSQNLRQIEIPKVSKRATKKENSHPAPQQPSQ---PVKDTVQEVTKVRRNLFNQ 918
Cdd:pfam15292 633 QLEELRTRSAKKRRKNALTRHRSMTESSQNLRQIEIPKKSKRATKSENSHSLLKTAVQqppPQKDTVQEVTKVRRNLFNQ 712
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 919 ELLSPSKRSLkrgLPRSHSVSAVDGLEDKLDNFKKNkGYHKLLTKSVAETPVHKQISKRLLHRQIKGRSSDPGPDIGVVE 998
Cdd:pfam15292 713 EIVSPSKRSK---LPRSQSVSAVEGLKHKRSSEKEE-DYHKLLTKKVAETPLHKQVSRRLLHRQIKGRSSDPGPDICIVE 788
|
....*
gi 808688280 999 ESPEK 1003
Cdd:pfam15292 789 ESPEK 793
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1085-1503 |
1.01e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.17 E-value: 1.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1085 RMKKRSRNTLDSEVPAAYQTPKKSHQKSLSfSKTTPRRISHTPQTPLYTPERLQKSPAKMTPTKQAAFKESLKDSSSPGH 1164
Cdd:PHA03247 2660 RVSRPRRARRLGRAAQASSPPQRPRRRAAR-PTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAA 2738
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1165 DSPLDSKITPQKRHTQAGEGTSLETKTPRTPKRQGTQPPGFLPNCTWPHSVNSSPESPSCPAPPTSSTAqprrecltpir 1244
Cdd:PHA03247 2739 PAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP----------- 2807
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1245 dPLRTPPRAAAF--MGTPQNQTHQQPHVLRAARAEEPAQKLKDKAIKTPKRPGNSTVTSSPPVTPKKLFTSPlcdvsKKS 1322
Cdd:PHA03247 2808 -PAAVLAPAAALppAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAP-----ARP 2881
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1323 PFRKSKIECPSPGELDQKEPQMSPSVAASLSCPVPSTPPELSQRATLDTVPPPPPSkvgkrcrktsdprrsivecQPDAS 1402
Cdd:PHA03247 2882 PVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPP-------------------RPQPP 2942
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1403 ATPGVGTADSPAAPTDSRDDQKGL----------SLSPQ----------SPPERRGYPGPGLrSDWHASSPLLITSDTEH 1462
Cdd:PHA03247 2943 LAPTTDPAGAGEPSGAVPQPWLGAlvpgrvavprFRVPQpapsreapasSTPPLTGHSLSRV-SSWASSLALHEETDPPP 3021
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 808688280 1463 VTLL------SEAEHhgiGDLKSNVLSVEEGEGLRTADAEKSSLSHP 1503
Cdd:PHA03247 3022 VSLKqtlwppDDTED---SDADSLFDSDSERSDLEALDPLPPEPHDP 3065
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1078-1442 |
1.10e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.17 E-value: 1.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1078 PSEKGSARMKKRSRNTLDSEVPAAYQTPKKSHQKSLSFSKTTPRriSHTPQTPLYTPeRLQKSPAKMTPTKQAAFKESLK 1157
Cdd:PHA03247 2577 PSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPD--THAPDPPPPSP-SPAANEPDPHPPPTVPPPERPR 2653
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1158 DSSSPGHDSPlDSKITPQKRHTQAgegtsleTKTPRTPKRQGTQPP-GFLPNCTWPHSVNSSPESPSCPA----PPTSST 1232
Cdd:PHA03247 2654 DDPAPGRVSR-PRRARRLGRAAQA-------SSPPQRPRRRAARPTvGSLTSLADPPPPPPTPEPAPHALvsatPLPPGP 2725
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1233 AQPRRECLTPIRDPL-RTPPRAAAFMGTPqnqthqqphvlraARAEEPAqklkdkaikTPKRPGNSTVTSSPPVTPKKLF 1311
Cdd:PHA03247 2726 AAARQASPALPAAPApPAVPAGPATPGGP-------------ARPARPP---------TTAGPPAPAPPAAPAAGPPRRL 2783
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1312 TSPlcDVSKKSPFRKSKIECPSPGELDQKEPQMSPSVAASLSCPVPSTPPELSQRATLDTVPPPPPSKV---GKRCRKTS 1388
Cdd:PHA03247 2784 TRP--AVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLplgGSVAPGGD 2861
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 808688280 1389 DPRRSIVECQPDASATPGVGTADSPAAPTDSRDDQKgLSLSPQSPPERRGYPGP 1442
Cdd:PHA03247 2862 VRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTES-FALPPDQPERPPQPQAP 2914
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
1150-1443 |
2.63e-06 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 52.87 E-value: 2.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1150 AAFKESLKDSSSPGHDSPLDSKITPQKRHT----QAGEGTSLETKTPRTPKRQGTQPPGFLPNCTWPHSVNSSPESPscP 1225
Cdd:PHA03307 15 AEGGEFFPRPPATPGDAADDLLSGSQGQLVsdsaELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWS--L 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1226 APPTSSTAQPRRECLTPIRDPLRTPPRAAAFMGTPQNQTHQQPHVLRAARAEEPAQKLKDKAIKTPKRPGNSTVTSSPPV 1305
Cdd:PHA03307 93 STLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1306 TPKKLFTSPL--CDVSKKSPFRKSkiecPSPGELDQKEPQMSPSVAASLSCPVPSTP--PELSQRATLDTVPPPPPSkvg 1381
Cdd:PHA03307 173 ALPLSSPEETarAPSSPPAEPPPS----TPPAAASPRPPRRSSPISASASSPAPAPGrsAADDAGASSSDSSSSESS--- 245
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 808688280 1382 krcRKTSDPRRSIVECQPDASATPGVGTADSPAAPTDSRddqKGLSLSPQSPPERRGYPGPG 1443
Cdd:PHA03307 246 ---GCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSR---PGPASSSSSPRERSPSPSPS 301
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
909-1407 |
3.48e-06 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 52.38 E-value: 3.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 909 TKVRRNLFNQELLSPSKRSlKRGLPrshSVSAVDglEDKLDNFKKNKGYHKLLTKSvaetPVHKQiskrllhrqikGRSS 988
Cdd:PTZ00449 474 TRISKIQFTQEIKKLIKKS-KKKLA---PIEEED--SDKHDEPPEGPEASGLPPKA----PGDKE-----------GEEG 532
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 989 DPGPDIGVvEESPEKGDEISLRRSPRIKQLSFSRTHSASfysvsqpKSRSVQRVHSFQQD-KSDQRENSPvqsiRSPKSl 1067
Cdd:PTZ00449 533 EHEDSKES-DEPKEGGKPGETKEGEVGKKPGPAKEHKPS-------KIPTLSKKPEFPKDpKHPKDPEEP----KKPKR- 599
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1068 lfgamseMISPSEKGSARMKKRSRNtldSEVPAAYQTPKkshqkslsfSKTTPRRiSHTPQTPLyTPERLQ--------K 1139
Cdd:PTZ00449 600 -------PRSAQRPTRPKSPKLPEL---LDIPKSPKRPE---------SPKSPKR-PPPPQRPS-SPERPEgpkiikspK 658
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1140 SPAKMTPTKQAAFKESLKDSSSPGHDSPLDSKITPQKRHTQAGEGTSLETKTPRTPKRQGTQPPGFLPncTWPHSVNSSP 1219
Cdd:PTZ00449 659 PPKSPKPPFDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLP--RDEEFPFEPI 736
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1220 ESPSCPAPPTSSTAQPRRECLTPIRDPLRTPPRAAAFmgtpqNQTHQQPHVlrAARAEEPaqklkDKAIKTPKRPG--NS 1297
Cdd:PTZ00449 737 GDPDAEQPDDIEFFTPPEEERTFFHETPADTPLPDIL-----AEEFKEEDI--HAETGEP-----DEAMKRPDSPSehED 804
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1298 TVTSSPPVTPKKLFTSPLCDVS----KKSPFRKSKIECPSPGEL-------DQKEPQMSPSVAASLSCPV---------- 1356
Cdd:PTZ00449 805 KPPGDHPSLPKKRHRLDGLALSttdlESDAGRIAKDASGKIVKLkrsksfdDLTTVEEAEEMGAEARKIVvdddgteadd 884
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 808688280 1357 -PSTPPELSQRATLDTVPPPPPSKVGKRCRKTSDPRRsivecqPDASATPGV 1407
Cdd:PTZ00449 885 eDTHPPEEKHKSEVRRRRPPKKPSKPKKPSKPKKPKK------PDSAFIPSI 930
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1195-1442 |
4.11e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 52.25 E-value: 4.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1195 PKRQGTQPPGflPNCTWPHSVNSSPESPSCPAPPTSSTAQPRRECLTPIRDPLRTPPRAAAFMGTPQNQTHQQPHVLRAA 1274
Cdd:PHA03247 2570 PPRPAPRPSE--PAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVP 2647
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1275 RAEEPAQKLKDKAIKTPKR---PGNSTVTSSPPVTPKKLFTSPlcDVSKKSPFRKSKIECPSPgeldqkEPQMSPSVAAS 1351
Cdd:PHA03247 2648 PPERPRDDPAPGRVSRPRRarrLGRAAQASSPPQRPRRRAARP--TVGSLTSLADPPPPPPTP------EPAPHALVSAT 2719
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1352 LSCPVPSTPPELSQRATLDTVPPPPPSKVGKRCRKTSDPRRSIVECQPDASATPGVGTADSPAAPTDSRDDQKGLSLSPQ 1431
Cdd:PHA03247 2720 PLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLP 2799
|
250
....*....|.
gi 808688280 1432 SPPERRGYPGP 1442
Cdd:PHA03247 2800 SPWDPADPPAA 2810
|
|
| GGN |
pfam15685 |
Gametogenetin; GGN is a family of proteins largely found in mammals. It reacts with POG in the ... |
1334-1501 |
4.40e-04 |
|
Gametogenetin; GGN is a family of proteins largely found in mammals. It reacts with POG in the maturation of sperm and is expressed virtually only in the testis. It is found to be associated with the intracellular membrane, binds with GGNBP1 and may be involved in vesicular trafficking.
Pssm-ID: 434857 [Multi-domain] Cd Length: 668 Bit Score: 45.14 E-value: 4.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1334 PGELDQKEPQMSPS-VAASLSCPVPST-PPELSQRATLDTVPPPP-------PSKvGKRCRKTSDPR-RSIVECQPDASA 1403
Cdd:pfam15685 59 PGLLVPPEPQASPSpLPLTLELPLPVTpPPEEAAAAAVSTAPPPAvgsllpaPSK-WRKPTGTAVARiRGLLEASHRGQG 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1404 TPGVGTADSPAAPTD--SRDDQKGLSLSPQSPPERRGYPGPGLRSDWHASS----PLLITSDTEHVTllSEAEHHGIGDL 1477
Cdd:pfam15685 138 DPLSLRPLLPLLPRQliEKDPAPGAPAPPPPTPLEPRKPPPLPPSDRQPPNrgitPALATSATSPTD--SQAKHIAEGKT 215
|
170 180
....*....|....*....|....*....
gi 808688280 1478 KSNVL-----SVEEGEGLRTAdAEKSSLS 1501
Cdd:pfam15685 216 AGGACggappQAGEGEMARFA-ASESGLS 243
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
922-1442 |
6.37e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 44.76 E-value: 6.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 922 SPSKRSLKRGLPRSHSVSAVDGLEDKLDNFKKNKgyhkllTKSVAETPVHKQISKRllhRQIKGRSSDPGPDIGVVEESp 1001
Cdd:pfam03154 33 SPTNEDLRSSGRNSPSAASTSSNDSKAESMKKSS------KKIKEEAPSPLKSAKR---QREKGASDTEEPERATAKKS- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1002 eKGDEISLRRSPRIKQLSFSRTHSASFYSVSQPK-----SRSVQRVHSFQQDKSDQRENSPVQSIR-------------- 1062
Cdd:pfam03154 103 -KTQEISRPNSPSEGEGESSDGRSVNDEGSSDPKdidqdNRSTSPSIPSPQDNESDSDSSAQQQILqtqppvlqaqsgaa 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1063 SPKSLLFGAMSEMISPSEKGSARMKKRSRNTLDSEVPAAYQTPKKSHQKSLSFSKTTPRRIS--HTPQTPLYTPERLQKS 1140
Cdd:pfam03154 182 SPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPspHPPLQPMTQPPPPSQV 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1141 PAKMTP-----TKQAAFKESLKDSSS----PGHDSPL-------DSKITPQKRHTQAGEGTSLETKTPRTPKRQGTQPPG 1204
Cdd:pfam03154 262 SPQPLPqpslhGQMPPMPHSLQTGPShmqhPVPPQPFpltpqssQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPR 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1205 FLPNCTWPHSVnsspesPSCPAPPTsstaqprreclTPIrdplrtPPraaafMGTPQNQTHqQPHVLRAARAEEPAQKLK 1284
Cdd:pfam03154 342 EQPLPPAPLSM------PHIKPPPT-----------TPI------PQ-----LPNPQSHKH-PPHLSGPSPFQMNSNLPP 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1285 DKAIKtpkrPGNSTVTSSPPvtpkKLFTSPLCDVSKKSPFRKSKIECPSPGELDQKEPQMSPSVAASLSCPVPSTPPels 1364
Cdd:pfam03154 393 PPALK----PLSSLSTHHPP----SAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSP--- 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1365 qRATLDTVPPPPPSKVGKRCRKTSDPrRSIVECQPDASATPGV-----GTADSPAAPTDSRDDQKGLSLSPQSPPERRGY 1439
Cdd:pfam03154 462 -FPQHPFVPGGPPPITPPSGPPTSTS-SAMPGIQPPSSASVSSsgpvpAAVSCPLPPVQIKEEALDEAEEPESPPPPPRS 539
|
...
gi 808688280 1440 PGP 1442
Cdd:pfam03154 540 PSP 542
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
1322-1706 |
1.41e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 43.62 E-value: 1.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1322 SPFRKSKIECPSPGELDQKEPQMSPSVAASLSCPVPSTPPELSQRATLDTVPPPPPSkvgkrcrkTSDPrrsiveCQPDA 1401
Cdd:PHA03307 63 DRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPP--------TPPP------ASPPP 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1402 SATPGVGTADSPAAPTDSRDDQkglslSPQSPPERRGYPGPGLRSDWHASSPLLITSDTEHVtllseaehhGIGDLKSNV 1481
Cdd:PHA03307 129 SPAPDLSEMLRPVGSPGPPPAA-----SPPAAGASPAAVASDAASSRQAALPLSSPEETARA---------PSSPPAEPP 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1482 LSVEEGEGLRTADAEKSSLSHPGIPPSPpscgpgsplMPSRDvhcttdgrqcqasaQLDNLPASAWHSTDSASPQTYEVE 1561
Cdd:PHA03307 195 PSTPPAAASPRPPRRSSPISASASSPAP---------APGRS--------------AADDAGASSSDSSSSESSGCGWGP 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1562 LEMQASGLPKLrikKIDPSSSLEAEPLSKEESSLGEESFLPALSMPRASRSLSKPEPTYVSPPCPRLSHSTP------GK 1635
Cdd:PHA03307 252 ENECPLPRPAP---ITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSsresssSS 328
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 808688280 1636 SRGQTYICQACTPTHGPSSTPSPFQTDGVPWTP-------SPKHSGKTTPDIIKDWPRRKRAVGCGAGSSSGRGEVGA 1706
Cdd:PHA03307 329 TSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADpssprkrPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGR 406
|
|
| PHA03377 |
PHA03377 |
EBNA-3C; Provisional |
1030-1419 |
2.03e-03 |
|
EBNA-3C; Provisional
Pssm-ID: 177614 [Multi-domain] Cd Length: 1000 Bit Score: 43.12 E-value: 2.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1030 SVSQPKSRSVQRVHSFQQDKSDQRENSPvqsirsPKsllfgamsemISPSEKGSARMKKRSRNTLDSEVPAAyqTPKKSH 1109
Cdd:PHA03377 525 SVTQPAKPHRKVQDGFQRSGRRQKRATP------PK----------VSPSDRGPPKASPPVMAPPSTGPRVM--ATPSTG 586
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1110 QKSLSFSKTTPRRISHTPQTPLYTPERLQK----SPAKMTPTKqaaFKESLKDSSSPGHDSPlDSKITPQKRHTQAGEGT 1185
Cdd:PHA03377 587 PRDMAPPSTGPRQQAKCKDGPPASGPHEKQppssAPRDMAPSV---VRMFLRERLLEQSTGP-KPKSFWEMRAGRDGSGI 662
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1186 SLETKTPRTPKRQGTQP-PGFLPN--------CTWPHSVNSSPESPSCPAPPTSSTAQPRRE--------CLTPIRDPLr 1248
Cdd:PHA03377 663 QQEPSSRRQPATQSTPPrPSWLPSvfvlpsvdAGRAQPSEESHLSSMSPTQPISHEEQPRYEdpddpldlSLHPDQAPP- 741
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1249 tPPRAAAFMGTPQNQTHQQPHvlrAARAEEPAQKLKDKAIKTPKRPGNSTVTSSPPVTPKKLFTSPLCDVSKKSPFRKSK 1328
Cdd:PHA03377 742 -PSHQAPYSGHEEPQAQQAPY---PGYWEPRPPQAPYLGYQEPQAQGVQVSSYPGYAGPWGLRAQHPRYRHSWAYWSQYP 817
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1329 IECPSPGELDQKEPQMSPSVAASL--------------SCPVPSTP-----PELSQRATLDTVPPPPPSkvgkrcrktSD 1389
Cdd:PHA03377 818 GHGHPQGPWAPRPPHLPPQWDGSAghgqdqvsqfphlqSETGPPRLqlsqvPQLPYSQTLVSSSAPSWS---------SP 888
|
410 420 430
....*....|....*....|....*....|
gi 808688280 1390 PRRSIVECQPDASATPGVGTADSPAAPTDS 1419
Cdd:PHA03377 889 QPRAPIRPIPTRFPPPPMPLQDSMAVGCDS 918
|
|
| PHA03379 |
PHA03379 |
EBNA-3A; Provisional |
1180-1399 |
2.45e-03 |
|
EBNA-3A; Provisional
Pssm-ID: 223066 [Multi-domain] Cd Length: 935 Bit Score: 42.74 E-value: 2.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1180 QAGEGTSLETKT---PRTPKRQGTQPPGFLPNCTWPHSVNSSPE--SPSCPAPPTSSTAQPrreclTPIRD-------PL 1247
Cdd:PHA03379 393 RAGKLTERAREAlekASEPTYGTPRPPVEKPRPEVPQSLETATShgSAQVPEPPPVHDLEP-----GPLHDqhsmapcPV 467
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1248 RTPPRAAAFMGTPQNqthQQPHVLRAAR-AEEPAQKLKDKAIktpkRPGNSTVTSSPPVTPKKLFTSPLCDVSKKSP-FR 1325
Cdd:PHA03379 468 AQLPPGPLQDLEPGD---QLPGVVQDGRpACAPVPAPAGPIV----RPWEASLSQVPGVAFAPVMPQPMPVEPVPVPtVA 540
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808688280 1326 KSKIECPSPGELDQKEP-QMSPSVAASLSCPVPSTPPElsqratldtvPPPPPSKVGKRC-----RKTSDPRRSIVECQP 1399
Cdd:PHA03379 541 LERPVCPAPPLIAMQGPgETSGIVRVRERWRPAPWTPN----------PPRSPSQMSVRDrlarlRAEAQPYQASVEVQP 610
|
|
| |
