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Conserved domains on  [gi|815890908|ref|NP_001295102|]
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cyclin-J-like protein isoform b [Homo sapiens]

Protein Classification

cyclin-J family protein( domain architecture ID 15334186)

cyclin-J family protein is involved in cell cycle regulation

Gene Ontology:  GO:0000079|GO:0016538
PubMed:  23861057|30185601

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNJ-like_rpt2 cd20529
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 145-246 1.01e-35

second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410232 [Multi-domain]  Cd Length: 101  Bit Score: 126.33  E-value: 1.01e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890908 145 PTPAHFLDYYLLASVSQKDHHChTWPTTCPRKTKECLKEYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPYW 224
Cdd:cd20529    1 PTPAHFLEYYLSQGVLFVDDHD-GLPSELLEKVKEYVRKYADFFLDLSLQDYAFLNYKPSLLAAACIAAARKALGLSPTW 79

                         90       100
                 ....*....|....*....|..
gi 815890908 225 TRDLQRISSYSLEHLSTCIEIL 246
Cdd:cd20529   80 PEELEKLTGYSEDELEPCVELL 101
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 33-116 4.41e-34

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 121.94  E-value: 4.41e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890908  33 SPLLKSRRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTTSkQLYTVAVSCLLLASKFEDREDHVPKLEQINST 112
Cdd:cd20528    1 SPQLHLRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISED-QLHLVALTCLLLAAKFEELDDNIPKISDLNRY 79


                 ....
gi 815890908 113 RILS 116
Cdd:cd20528   80 LCNS 83
 
Name Accession Description Interval E-value
CYCLIN_CCNJ-like_rpt2 cd20529
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 145-246 1.01e-35

second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410232 [Multi-domain]  Cd Length: 101  Bit Score: 126.33  E-value: 1.01e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890908 145 PTPAHFLDYYLLASVSQKDHHChTWPTTCPRKTKECLKEYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPYW 224
Cdd:cd20529    1 PTPAHFLEYYLSQGVLFVDDHD-GLPSELLEKVKEYVRKYADFFLDLSLQDYAFLNYKPSLLAAACIAAARKALGLSPTW 79

                         90       100
                 ....*....|....*....|..
gi 815890908 225 TRDLQRISSYSLEHLSTCIEIL 246
Cdd:cd20529   80 PEELEKLTGYSEDELEPCVELL 101
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 33-116 4.41e-34

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 121.94  E-value: 4.41e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890908  33 SPLLKSRRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTTSkQLYTVAVSCLLLASKFEDREDHVPKLEQINST 112
Cdd:cd20528    1 SPQLHLRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISED-QLHLVALTCLLLAAKFEELDDNIPKISDLNRY 79


                 ....
gi 815890908 113 RILS 116
Cdd:cd20528   80 LCNS 83
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 145-247 3.87e-17

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 76.89  E-value: 3.87e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890908  145 PTPAHFLDYYLLASVSQKDHHCHTwpttcprktkeclkeYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQlSPYW 224
Cdd:pfam02984   1 PTPLSFLRRFSKAADYLHDLELRT---------------LAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLN-SPEW 64

                          90       100
                  ....*....|....*....|...
gi 815890908  225 TRDLQRISSYSLEHLSTCIEILL 247
Cdd:pfam02984  65 TETLEHYTGYSEEDLKPCVKLLL 87
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
39-247 7.01e-11

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 63.26  E-value: 7.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890908  39 RRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTTSKqLYTVAVSCLLLASKFEdrEDHVPKLEQINstrILSSQ 118
Cdd:COG5024  213 RSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEK-YQLVGISALFIASKYE--EVNCPSIKDLV---YATDG 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890908 119 NFTltKKELLSTELLLLEAFSWNLCLPTPAHFLDYylLASVSQKDHhchtwpttcprktkeCLKEYAHYFLEVTLQDHIF 198
Cdd:COG5024  287 AFT--RDDIIRAERYMLEVLDFNISWPSPMSFLRR--ISKASDYDI---------------FSRTPAKFSSEISPVDYKF 347

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 815890908 199 YKFQPSVVAAACVGASRICLQLSPyWTRDLQRISS-YSLEHLSTCIEILL 247
Cdd:COG5024  348 IQISPSWCAAAAMYLSRKILSQNQ-WDRTLIHYSGnYTNPDLKPLNESNK 396
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 14-107 2.08e-10

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 57.91  E-value: 2.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890908   14 DVHCTLREKELKLPtfRAHSPLLKS-------RRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTTSKqLYTVA 86
Cdd:pfam00134   1 DIFQYLRELELKYL--PKPDYMDQQpdinpkmRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNK-LQLVG 77

                          90       100
                  ....*....|....*....|.
gi 815890908   87 VSCLLLASKFEdrEDHVPKLE 107
Cdd:pfam00134  78 VTCLFIAAKYE--EIYPPTVE 96
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 46-109 5.49e-08

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 49.90  E-value: 5.49e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 815890908    46 LTLLSSHCQLCPAARHLAVYLLDHFMDRYNVtTSKQLYTVAVSCLLLASKFEDREDHVPKLEQI 109
Cdd:smart00385   3 LRRVCKALNLDPETLNLAVNLLDRFLSDYKF-LKYSPSLIAAAALYLASKTEETPPWTKELVHY 65
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 185-247 1.15e-04

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 40.27  E-value: 1.15e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 815890908   185 AHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPyWTRDLQRISSY-SLEHLSTCIEILL 247
Cdd:smart00385  20 AVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPP-WTKELVHYTGYfTEEEILRMERLLL 82
 
Name Accession Description Interval E-value
CYCLIN_CCNJ-like_rpt2 cd20529
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 145-246 1.01e-35

second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410232 [Multi-domain]  Cd Length: 101  Bit Score: 126.33  E-value: 1.01e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890908 145 PTPAHFLDYYLLASVSQKDHHChTWPTTCPRKTKECLKEYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPYW 224
Cdd:cd20529    1 PTPAHFLEYYLSQGVLFVDDHD-GLPSELLEKVKEYVRKYADFFLDLSLQDYAFLNYKPSLLAAACIAAARKALGLSPTW 79

                         90       100
                 ....*....|....*....|..
gi 815890908 225 TRDLQRISSYSLEHLSTCIEIL 246
Cdd:cd20529   80 PEELEKLTGYSEDELEPCVELL 101
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 33-116 4.41e-34

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 121.94  E-value: 4.41e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890908  33 SPLLKSRRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTTSkQLYTVAVSCLLLASKFEDREDHVPKLEQINST 112
Cdd:cd20528    1 SPQLHLRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISED-QLHLVALTCLLLAAKFEELDDNIPKISDLNRY 79


                 ....
gi 815890908 113 RILS 116
Cdd:cd20528   80 LCNS 83
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 145-247 3.87e-17

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 76.89  E-value: 3.87e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890908  145 PTPAHFLDYYLLASVSQKDHHCHTwpttcprktkeclkeYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQlSPYW 224
Cdd:pfam02984   1 PTPLSFLRRFSKAADYLHDLELRT---------------LAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLN-SPEW 64

                          90       100
                  ....*....|....*....|...
gi 815890908  225 TRDLQRISSYSLEHLSTCIEILL 247
Cdd:pfam02984  65 TETLEHYTGYSEEDLKPCVKLLL 87
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 145-252 9.70e-14

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 66.18  E-value: 9.70e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890908 145 PTPAHFLDYYL-LASVSQKDHHChtwpttcprktkeclkeyAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPY 223
Cdd:cd20537    1 PTPLSFLRRYLsLLGLDEKVRHL------------------ARYLLELSLLDYEFLKYRPSLIAAAALYLARKILGEPPP 62

                         90       100
                 ....*....|....*....|....*....
gi 815890908 224 WTRDLQRISSYSLEHLSTCIEILLVVYDN 252
Cdd:cd20537   63 SPQLLQLVTGYSENDLQECAKELLELLAQ 91
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
39-247 7.01e-11

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 63.26  E-value: 7.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890908  39 RRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTTSKqLYTVAVSCLLLASKFEdrEDHVPKLEQINstrILSSQ 118
Cdd:COG5024  213 RSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEK-YQLVGISALFIASKYE--EVNCPSIKDLV---YATDG 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890908 119 NFTltKKELLSTELLLLEAFSWNLCLPTPAHFLDYylLASVSQKDHhchtwpttcprktkeCLKEYAHYFLEVTLQDHIF 198
Cdd:COG5024  287 AFT--RDDIIRAERYMLEVLDFNISWPSPMSFLRR--ISKASDYDI---------------FSRTPAKFSSEISPVDYKF 347

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 815890908 199 YKFQPSVVAAACVGASRICLQLSPyWTRDLQRISS-YSLEHLSTCIEILL 247
Cdd:COG5024  348 IQISPSWCAAAAMYLSRKILSQNQ-WDRTLIHYSGnYTNPDLKPLNESNK 396
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 14-107 2.08e-10

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 57.91  E-value: 2.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890908   14 DVHCTLREKELKLPtfRAHSPLLKS-------RRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTTSKqLYTVA 86
Cdd:pfam00134   1 DIFQYLRELELKYL--PKPDYMDQQpdinpkmRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNK-LQLVG 77

                          90       100
                  ....*....|....*....|.
gi 815890908   87 VSCLLLASKFEdrEDHVPKLE 107
Cdd:pfam00134  78 VTCLFIAAKYE--EIYPPTVE 96
CYCLIN_AtCycB-like_rpt2 cd20511
second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 145-252 2.41e-10

second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410215  Cd Length: 117  Bit Score: 57.70  E-value: 2.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890908 145 PTPAHFLDYYLLASVSQKDhhchtwpttcprktkecLKEYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPYW 224
Cdd:cd20511    1 PTPYVFLVRFLKAAQSDKK-----------------LENLAFFLVELGLVEYEMLKYSPSMLAASAVYTARCTLNKTPEW 63

                         90       100
                 ....*....|....*....|....*...
gi 815890908 225 TRDLQRISSYSLEHLSTCIEILLVVYDN 252
Cdd:cd20511   64 TSTLEFHTGYSESQLMECARLMVRLHSK 91
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 145-246 1.19e-08

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410210  Cd Length: 111  Bit Score: 52.64  E-value: 1.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890908 145 PTPAHFLDYYLlaSVSQKDHhchtwpttcPRKTKECLkeyAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPyW 224
Cdd:cd20506    1 PTIKTFLRRFL--RAAQASV---------PDLKLEFL---ANYLAELSLLDYEFLKYLPSLIAASAVFLARHTLNPHP-W 65

                         90       100
                 ....*....|....*....|..
gi 815890908 225 TRDLQRISSYSLEHLSTCIEIL 246
Cdd:cd20506   66 NPTLEHYTGYKAADLKPCVQAL 87
CYCLIN_CCNA_rpt2 cd20505
second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 145-252 1.71e-08

second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410209 [Multi-domain]  Cd Length: 110  Bit Score: 51.91  E-value: 1.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890908 145 PTPAHFLDYYLlasvsqkdHHCHTWPTTcprktkECLkeyAHYFLEVTLQD-HIFYKFQPSVVAAACVGASRICLQlSPY 223
Cdd:cd20505    1 PTSNWFLERFL--------KHSNADEKT------KSL---AMYLCELSLIDaDPYLKYLPSVIAAAAVCLANHTLG-NEV 62

                         90       100
                 ....*....|....*....|....*....
gi 815890908 224 WTRDLQRISSYSLEHLSTCIEILLVVYDN 252
Cdd:cd20505   63 WPQKLARSTGYSLEDLLPCLRDLHRTFLN 91
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 46-109 5.49e-08

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 49.90  E-value: 5.49e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 815890908    46 LTLLSSHCQLCPAARHLAVYLLDHFMDRYNVtTSKQLYTVAVSCLLLASKFEDREDHVPKLEQI 109
Cdd:smart00385   3 LRRVCKALNLDPETLNLAVNLLDRFLSDYKF-LKYSPSLIAAAALYLASKTEETPPWTKELVHY 65
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 12-108 1.44e-07

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 50.10  E-value: 1.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890908  12 ASDVHCTLREKELK---LPTF--RAHSPLLKSRR-FFVDILTLLSSHCQLCPAARHLAVYLLDHFMDrYNVTTSKQLYTV 85
Cdd:cd20562    9 ATDIYLNLRVAELKrrpLPDYmeKIQRDITPSMRgILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLS-GNYVNRQRLQLL 87

                         90       100
                 ....*....|....*....|...
gi 815890908  86 AVSCLLLASKFEdrEDHVPKLEQ 108
Cdd:cd20562   88 GVSCMLIASKYE--EICAPQVEE 108
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 19-107 3.97e-07

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 48.83  E-value: 3.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890908  19 LREKELKL---PTFRAHSPLL--KSRRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTTSK-QLytVAVSCLLL 92
Cdd:cd20568   16 LRELELKTlpnPNYMDDQKELrwKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLSKRVVSLNKlQL--VGISALFI 93

                         90
                 ....*....|....*
gi 815890908  93 ASKFEdrEDHVPKLE 107
Cdd:cd20568   94 ASKYE--EVNSPSIK 106
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 43-109 1.33e-06

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 45.86  E-value: 1.33e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 815890908  43 VDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTtSKQLYTVAVSCLLLASKFEDREDHVPKLEQI 109
Cdd:cd00043    3 VDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLL-GRSPELIAAACLYLACKLEELPRTLKEIAKV 68
CYCLIN_CLBs_yeast_rpt2 cd20512
second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae ...
 185-247 1.52e-06

second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410216  Cd Length: 116  Bit Score: 46.45  E-value: 1.52e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 815890908 185 AHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQlSPYWTRDLQRISSYSLEHLSTCIEILL 247
Cdd:cd20512   23 AKYLLEITILDHRFLGYPPSLLAAAAMYLARKMLG-RGDWNDNLVHYSGYTESQLIPCADIML 84
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 12-98 2.41e-06

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 46.37  E-value: 2.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890908  12 ASDVHCTLREKELKL---PTFRAHSPLL--KSRRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTtSKQLYTVA 86
Cdd:cd20507    5 VKDIYKYLRQLEKKYaidPDYLSGQPEIteRMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVP-RKKLQLVG 83

                         90
                 ....*....|..
gi 815890908  87 VSCLLLASKFED 98
Cdd:cd20507   84 VTALLIASKYEE 95
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 39-99 2.95e-06

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 45.39  E-value: 2.95e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 815890908  39 RRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTTSK-QLytVAVSCLLLASKFEDR 99
Cdd:cd20542    1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLlQL--LGITCLFIACKFEER 60
CYCLIN_CCNB1-like_rpt2 cd20509
second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 185-250 4.88e-06

second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410213  Cd Length: 111  Bit Score: 44.91  E-value: 4.88e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 815890908 185 AHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQlSPYWTRDLQRISSYSLEHLSTCIEILLVVY 250
Cdd:cd20509   24 AKYLMELTLLDYDMVHYKPSEIAAAALCLSRKILD-EPEWTPTLEHYSTYSEEDLLPIVQKMAKLV 88
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 39-110 5.50e-05

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 41.92  E-value: 5.50e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 815890908  39 RRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTTSK----QLytVAVSCLLLASKFEdrEDHVPKLEQIN 110
Cdd:cd20543    2 RNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDKpwmlQL--LAVACLSLAAKME--ETDVPLLVDLQ 73
CYCLIN_SDS-like_rpt2 cd20721
second cyclin box found in Arabidopsis thaliana cyclin-SDS and similar proteins; Cyclin-SDS, ...
 145-224 1.14e-04

second cyclin box found in Arabidopsis thaliana cyclin-SDS and similar proteins; Cyclin-SDS, also called protein SOLO DANCERS, is a meiosis-specific cyclin that is required for normal homolog synapsis and recombination in early to mid-prophase 1. It contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410310  Cd Length: 104  Bit Score: 40.96  E-value: 1.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890908 145 PTPAHFLDYYLLASVSQKDhhchtwPTTCPRKtkecLKEYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPYW 224
Cdd:cd20721    1 PTILTFLRMYIERLSLESG------AAHASRP----LERLAMFLAEISLLHYSFLQFRPSTVAAACLVLAEIMHNRPAAW 70
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 185-247 1.15e-04

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 40.27  E-value: 1.15e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 815890908   185 AHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPyWTRDLQRISSY-SLEHLSTCIEILL 247
Cdd:smart00385  20 AVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPP-WTKELVHYTGYfTEEEILRMERLLL 82
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 12-98 1.31e-04

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 41.58  E-value: 1.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890908  12 ASDVHCTLREKELKLPT---FRAHSPLLKS--RRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTTSKqLYTVA 86
Cdd:cd20561    5 HEDIHTYLREMEVKCKPkvgYMKKQPDITNsmRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGK-LQLVG 83

                         90
                 ....*....|..
gi 815890908  87 VSCLLLASKFED 98
Cdd:cd20561   84 TAAMLLASKFEE 95
CYCLIN_CCNO_rpt2 cd20722
second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of ...
 145-244 3.35e-04

second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410311  Cd Length: 97  Bit Score: 39.64  E-value: 3.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890908 145 PTPAHFLDYYLLASVSqkdhhchTWPTTCPRKTKEClKEYAHYFLEVTLQDHIFYKFQPSVVAAACVgasRICLQLSPYW 224
Cdd:cd20722    1 PTLQFFLEHFSSLRLE-------NRELSCAEEARKA-RALARYLAELSLADYAFNQYPPSLLAICSL---ELADRMLQHR 69

                         90       100
                 ....*....|....*....|
gi 815890908 225 TRDLQRISSYSLEHLSTCIE 244
Cdd:cd20722   70 SPITERLSGYPQSALEDCVG 89
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 12-97 4.32e-04

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 39.92  E-value: 4.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890908  12 ASDVHCTLREKELKlptFRAHSPLLKS--------RRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTTSK-QL 82
Cdd:cd20504    3 ADDIYEYLRESELK---HRPKPDYMRKqpdinpsmRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSKlQL 79

                         90
                 ....*....|....*
gi 815890908  83 ytVAVSCLLLASKFE 97
Cdd:cd20504   80 --VGTACMFIAAKYE 92
CYCLIN_CCNB3_rpt2 cd20510
second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 ...
 185-246 1.14e-03

second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410214  Cd Length: 115  Bit Score: 38.42  E-value: 1.14e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 815890908 185 AHYFLEVTLQDHIFYKFQPSVVAAACVGASrICLQLSPYWTRDLQRISSYSLEHLSTCIEIL 246
Cdd:cd20510   24 ARYILELSLMEYQFVQERASKLAAAALLLA-LKMKNLGEWTPTLEYYSGYSAEDLLPLVRKL 84
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 46-107 3.21e-03

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 36.91  E-value: 3.21e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 815890908  46 LTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTtSKQLYTVAVSCLLLASKFEDREDHVPKLE 107
Cdd:cd20526    9 LAELNSQFKFYPETFALAVSILDRFLASVKAR-PKYLRCIAISCLFLAAKTNEEDEVIPSTK 69
CYCLIN_CCNF_rpt2 cd20522
second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, ...
 185-242 4.51e-03

second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410226  Cd Length: 112  Bit Score: 36.45  E-value: 4.51e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 815890908 185 AHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPYWTRDLQRISSYSLEHLSTC 242
Cdd:cd20522    3 ASYICELSLLHTELGRYSPAVIAASCLLLARVLLNQALPWPSQLEEFTGFSLEDLLSC 60
CYCLIN_CCND_rpt2 cd20516
second cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 173-246 4.65e-03

second cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410220  Cd Length: 98  Bit Score: 36.05  E-value: 4.65e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 815890908 173 CPRKTKECLKEYAHYFLEVTLQDHIFYKFQPSVVAAACVGASRICLQLSPYWTRD-----LQRISSYSLEHLSTCIEIL 246
Cdd:cd20516   15 LDSEDVDKVRKHAETFIALCATDYKFSSYPPSMIAAASILAALRGLLLHSGNSKEdllekLQQLTRIDEDLLRACQEQI 93
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 20-99 4.85e-03

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 37.23  E-value: 4.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815890908  20 REKELKLPTFRAHSPLL--KSRRFFVDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTTSK-QLytVAVSCLLLASKF 96
Cdd:cd20508   27 REEKFVVPDYLEKQTELtpSMRAILVDWLVEVQENFELNHETLYLAVKLVDLYLSKKVVKKEKlQL--LGATAILIASKF 104


                 ...
gi 815890908  97 EDR 99
Cdd:cd20508  105 DER 107
CYCLIN_AtCycD-like_rpt2 cd20544
second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant ...
 146-209 5.07e-03

second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410247  Cd Length: 90  Bit Score: 35.75  E-value: 5.07e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 815890908 146 TPAHFLDYyLLASVSQKDHHCHtwpttcprktkecLKEYAHYFLEVTLQDHIFYKFQPSVVAAA 209
Cdd:cd20544    2 TPFSFLDY-FISKIGLSDSREE-------------LLSRATELLLSTTKDIRFLEYRPSVIAAA 51
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 43-107 7.17e-03

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 35.82  E-value: 7.17e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 815890908  43 VDILTLLSSHCQLCPAARHLAVYLLDHFMDRYNVTtSKQLYTVAVSCLLLASKFEDREDHVPKLE 107
Cdd:cd20559    3 LDFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVL-KKHYQLVGCTCLWIASKFWESKARVPLLS 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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