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Conserved domains on  [gi|815930068|ref|NP_001295244|]
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tetraspanin-2 isoform 2 [Homo sapiens]

Protein Classification

tetraspanin family protein( domain architecture ID 13626491)

tetraspanin family protein is a transmembrane (TM) protein with four TM segments that acts as a molecular facilitator in diverse processes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CD81_like_LEL cd03151
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. ...
 85-161 1.95e-27

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD81, also referred to as Target for anti-proliferative antigen-1, TAPA-1, is found in virtually all tissues, may be involved in regulation of cell growth and has been described as a member of the CD19/CD21/Leu-13 signal transduction complex identified on B cells (the B-Cell co-receptor).


:

Pssm-ID: 239404  Cd Length: 84  Bit Score: 99.03  E-value: 1.95e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815930068  85 QCVLGSAIRHVQTMYEEAYNDYLKD-RGKGNGTLITFHSTFQCCGKESSEQ-----VQPTCPKEL-LGHKNCIDEIETII 157
Cdd:cd03151    1 FINKDQIIKEVQNFYDSAYQDAVTDtRSKGTAVLKTFHSTLDCCGKGNLTAllsllSTDLCPKKLlLDTKDCHQEIDDLF 80


                 ....
gi 815930068 158 SVKL 161
Cdd:cd03151   81 SEKL 84
Tetraspanin pfam00335
Tetraspanin family;
11-187 7.38e-19

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 79.67  E-value: 7.38e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815930068   11 IKYLLLGFNLLFWLAGSAVIAFGLWFRfggaIKELSSEDKSPEYFYVGLYVLVGAGALMMAVGFFGCCGAMRESQCVLGS 90
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLL----SAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLT 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815930068   91 -----------------------------AIRHVQTMYEEAYNDYLKDRGKGNGTLITFHSTFQCCGkesseqvqptcpk 141
Cdd:pfam00335  77 yfvlllllflaelaagilafvyrdklsglLSNWLKKSLEDGYRDWLDLYSCLNSALDSLQSEFGCCG------------- 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 815930068  142 ellghkNCIDEIETIISVKLQLIGIVGIGIAGLTIFGMIFSMVLCC 187
Cdd:pfam00335 144 ------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
 
Name Accession Description Interval E-value
CD81_like_LEL cd03151
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. ...
 85-161 1.95e-27

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD81, also referred to as Target for anti-proliferative antigen-1, TAPA-1, is found in virtually all tissues, may be involved in regulation of cell growth and has been described as a member of the CD19/CD21/Leu-13 signal transduction complex identified on B cells (the B-Cell co-receptor).


Pssm-ID: 239404  Cd Length: 84  Bit Score: 99.03  E-value: 1.95e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815930068  85 QCVLGSAIRHVQTMYEEAYNDYLKD-RGKGNGTLITFHSTFQCCGKESSEQ-----VQPTCPKEL-LGHKNCIDEIETII 157
Cdd:cd03151    1 FINKDQIIKEVQNFYDSAYQDAVTDtRSKGTAVLKTFHSTLDCCGKGNLTAllsllSTDLCPKKLlLDTKDCHQEIDDLF 80


                 ....
gi 815930068 158 SVKL 161
Cdd:cd03151   81 SEKL 84
Tetraspanin pfam00335
Tetraspanin family;
11-187 7.38e-19

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 79.67  E-value: 7.38e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815930068   11 IKYLLLGFNLLFWLAGSAVIAFGLWFRfggaIKELSSEDKSPEYFYVGLYVLVGAGALMMAVGFFGCCGAMRESQCVLGS 90
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLL----SAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLT 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815930068   91 -----------------------------AIRHVQTMYEEAYNDYLKDRGKGNGTLITFHSTFQCCGkesseqvqptcpk 141
Cdd:pfam00335  77 yfvlllllflaelaagilafvyrdklsglLSNWLKKSLEDGYRDWLDLYSCLNSALDSLQSEFGCCG------------- 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 815930068  142 ellghkNCIDEIETIISVKLQLIGIVGIGIAGLTIFGMIFSMVLCC 187
Cdd:pfam00335 144 ------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
 
Name Accession Description Interval E-value
CD81_like_LEL cd03151
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. ...
 85-161 1.95e-27

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD81, also referred to as Target for anti-proliferative antigen-1, TAPA-1, is found in virtually all tissues, may be involved in regulation of cell growth and has been described as a member of the CD19/CD21/Leu-13 signal transduction complex identified on B cells (the B-Cell co-receptor).


Pssm-ID: 239404  Cd Length: 84  Bit Score: 99.03  E-value: 1.95e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815930068  85 QCVLGSAIRHVQTMYEEAYNDYLKD-RGKGNGTLITFHSTFQCCGKESSEQ-----VQPTCPKEL-LGHKNCIDEIETII 157
Cdd:cd03151    1 FINKDQIIKEVQNFYDSAYQDAVTDtRSKGTAVLKTFHSTLDCCGKGNLTAllsllSTDLCPKKLlLDTKDCHQEIDDLF 80


                 ....
gi 815930068 158 SVKL 161
Cdd:cd03151   81 SEKL 84
Tetraspanin pfam00335
Tetraspanin family;
11-187 7.38e-19

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 79.67  E-value: 7.38e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815930068   11 IKYLLLGFNLLFWLAGSAVIAFGLWFRfggaIKELSSEDKSPEYFYVGLYVLVGAGALMMAVGFFGCCGAMRESQCVLGS 90
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLL----SAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLT 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 815930068   91 -----------------------------AIRHVQTMYEEAYNDYLKDRGKGNGTLITFHSTFQCCGkesseqvqptcpk 141
Cdd:pfam00335  77 yfvlllllflaelaagilafvyrdklsglLSNWLKKSLEDGYRDWLDLYSCLNSALDSLQSEFGCCG------------- 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 815930068  142 ellghkNCIDEIETIISVKLQLIGIVGIGIAGLTIFGMIFSMVLCC 187
Cdd:pfam00335 144 ------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
CD9_LEL cd03152
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD9 family. Tetraspanins ...
 92-161 3.89e-06

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD9 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD9 is found in virtually all tissues and is potentially involved in developmental processes. It associates with the tetraspanins CD81 and CD63, as well as with some integrin, and has been shown to be involved in a variety of activation, adhesion, and cell motility functions, as well as cell-cell interactions - such as during fertilization.


Pssm-ID: 239405  Cd Length: 84  Bit Score: 43.53  E-value: 3.89e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 815930068  92 IRHVQTMYEEAYNDYLKDRGKG-NGTLITFHSTFQCCGKES--SEQVQPTCPK-ELLGH---KNCIDEIETIISVKL 161
Cdd:cd03152    8 VKEVQTFYRQTYAKYKQSRDPPlKETLKAIHFALDCCGPTGglEQFVTDTCPKkEGLENlitKSCPDAIDDVFNSKL 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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