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Conserved domains on  [gi|924181709|ref|NP_001300689|]
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toll-like receptor 8 isoform 2 precursor [Mus musculus]

Protein Classification

toll-like receptor( domain architecture ID 12836164)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
529-788 2.53e-19

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.92  E-value: 2.53e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  529 RLDFDDNNAFSDLHDLEVLDLSHNAhyfsiagVTHRLGFIQNLINLRVLNLSHNGIYTLTEE-SELKsiSLKELVFSGNR 607
Cdd:COG4886   100 ELDLSGNEELSNLTNLESLDLSGNQ-------LTDLPEELANLTNLKELDLSNNQLTDLPEPlGNLT--NLKSLDLSNNQ 170
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  608 LDRLWNAndgkywsiFKSLQNLIRLDLSYNNLQQIPNgAFLNLPqSLQELLISGNKLRFFNWTLLQyFPHLHLLDLSRNE 687
Cdd:COG4886   171 LTDLPEE--------LGNLTNLKELDLSNNQITDLPE-PLGNLT-NLEELDLSGNQLTDLPEPLAN-LTNLETLDLSNNQ 239
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  688 LYFLPNcLSKFaHSLETLLLSHNHFSHLPSgfLSEARNLVHLDLSFNTIKMINKSSLQTKMKTNLSILELHGNYFDCTCD 767
Cdd:COG4886   240 LTDLPE-LGNL-TNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315
                         250       260
                  ....*....|....*....|.
gi 924181709  768 ISDFRSWLDENLNITIPKLVN 788
Cdd:COG4886   316 LLLLLTTLLLLLLLLKGLLVT 336
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
63-481 6.55e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.21  E-value: 6.55e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709   63 TNIDLSDNAITHITKESFQKLQNLTKIDLNHNAKQQHPNENKNGMNITEGALLSLRNLTVLLLEDNQLYTIPA-GLPESL 141
Cdd:COG4886    19 ELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDlGDLTNL 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  142 KELSLIQNNIFqvtknntFGLRNLERLYLGWNcyfkcnqTFKVEDGAFKNLIHLKVLSLSFNNLFYVPPKLPS--SLRKL 219
Cdd:COG4886    99 TELDLSGNEEL-------SNLTNLESLDLSGN-------QLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNltNLKSL 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  220 FLSNAKIMNITQEdFKGLENLTLLDLSGNcprcynapfpctpckensSIHIHPLAFQSLTQLLYLNLSSTSLRTIPSTwF 299
Cdd:COG4886   165 DLSNNQLTDLPEE-LGNLTNLKELDLSNN------------------QITDLPEPLGNLTNLEELDLSGNQLTDLPEP-L 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  300 ENLSNLKELHLEFNylvqEIASGAFLTKLPSLQILDLSFNfqykeylQFINISSNfSKLRSLKKLHLRGYVFRELKKKHF 379
Cdd:COG4886   225 ANLTNLETLDLSNN----QLTDLPELGNLTNLEELDLSNN-------QLTDLPPL-ANLTNLKTLDLSNNQLTDLKLKEL 292
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  380 EHLQSLPNLATINLGINFIEKIDFKAFQNFSKLDVIYLSGNRIASVLDGTDYSSWRNRLRKPLSTDDDEFDPHVNFYHST 459
Cdd:COG4886   293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLL 372
                         410       420
                  ....*....|....*....|..
gi 924181709  460 KPLIKPQCTAYGKALDLSLNNI 481
Cdd:COG4886   373 GLLEATLLTLALLLLTLLLLLL 394
TIR smart00255
Toll - interleukin 1 - resistance;
868-1004 3.12e-14

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 70.82  E-value: 3.12e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709    868 YDAYISYdtkdaSVTDWVINELRYHLEESEDKSVLlCLEERDWDPGLPIIDNLMQSINQSKKTIFVLTKKYAKSWNFKTA 947
Cdd:smart00255    2 YDVFISY-----SGKEDVRNEFLSHLLEKLRGYGL-CVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 924181709    948 FYLALQRLMDENMDVIIFILLEPVLQY--SQYLRLRqRICKSSILQWPNNPKAEnlFWQ 1004
Cdd:smart00255   76 LVAALENALEEGGLRVIPIFYEVIPSDvrKQPGKFR-KVFKKNYLKWPEDEKEQ--FWK 131
LRR_8 pfam13855
Leucine rich repeat;
498-552 3.91e-07

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 3.91e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 924181709   498 LNLSFNaNTQVFNGTEFSSMPHIKYLDLTNNRLDFDDNNAFSDLHDLEVLDLSHN 552
Cdd:pfam13855    6 LDLSNN-RLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
529-788 2.53e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.92  E-value: 2.53e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  529 RLDFDDNNAFSDLHDLEVLDLSHNAhyfsiagVTHRLGFIQNLINLRVLNLSHNGIYTLTEE-SELKsiSLKELVFSGNR 607
Cdd:COG4886   100 ELDLSGNEELSNLTNLESLDLSGNQ-------LTDLPEELANLTNLKELDLSNNQLTDLPEPlGNLT--NLKSLDLSNNQ 170
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  608 LDRLWNAndgkywsiFKSLQNLIRLDLSYNNLQQIPNgAFLNLPqSLQELLISGNKLRFFNWTLLQyFPHLHLLDLSRNE 687
Cdd:COG4886   171 LTDLPEE--------LGNLTNLKELDLSNNQITDLPE-PLGNLT-NLEELDLSGNQLTDLPEPLAN-LTNLETLDLSNNQ 239
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  688 LYFLPNcLSKFaHSLETLLLSHNHFSHLPSgfLSEARNLVHLDLSFNTIKMINKSSLQTKMKTNLSILELHGNYFDCTCD 767
Cdd:COG4886   240 LTDLPE-LGNL-TNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315
                         250       260
                  ....*....|....*....|.
gi 924181709  768 ISDFRSWLDENLNITIPKLVN 788
Cdd:COG4886   316 LLLLLTTLLLLLLLLKGLLVT 336
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
63-481 6.55e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.21  E-value: 6.55e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709   63 TNIDLSDNAITHITKESFQKLQNLTKIDLNHNAKQQHPNENKNGMNITEGALLSLRNLTVLLLEDNQLYTIPA-GLPESL 141
Cdd:COG4886    19 ELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDlGDLTNL 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  142 KELSLIQNNIFqvtknntFGLRNLERLYLGWNcyfkcnqTFKVEDGAFKNLIHLKVLSLSFNNLFYVPPKLPS--SLRKL 219
Cdd:COG4886    99 TELDLSGNEEL-------SNLTNLESLDLSGN-------QLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNltNLKSL 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  220 FLSNAKIMNITQEdFKGLENLTLLDLSGNcprcynapfpctpckensSIHIHPLAFQSLTQLLYLNLSSTSLRTIPSTwF 299
Cdd:COG4886   165 DLSNNQLTDLPEE-LGNLTNLKELDLSNN------------------QITDLPEPLGNLTNLEELDLSGNQLTDLPEP-L 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  300 ENLSNLKELHLEFNylvqEIASGAFLTKLPSLQILDLSFNfqykeylQFINISSNfSKLRSLKKLHLRGYVFRELKKKHF 379
Cdd:COG4886   225 ANLTNLETLDLSNN----QLTDLPELGNLTNLEELDLSNN-------QLTDLPPL-ANLTNLKTLDLSNNQLTDLKLKEL 292
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  380 EHLQSLPNLATINLGINFIEKIDFKAFQNFSKLDVIYLSGNRIASVLDGTDYSSWRNRLRKPLSTDDDEFDPHVNFYHST 459
Cdd:COG4886   293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLL 372
                         410       420
                  ....*....|....*....|..
gi 924181709  460 KPLIKPQCTAYGKALDLSLNNI 481
Cdd:COG4886   373 GLLEATLLTLALLLLTLLLLLL 394
TIR smart00255
Toll - interleukin 1 - resistance;
868-1004 3.12e-14

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 70.82  E-value: 3.12e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709    868 YDAYISYdtkdaSVTDWVINELRYHLEESEDKSVLlCLEERDWDPGLPIIDNLMQSINQSKKTIFVLTKKYAKSWNFKTA 947
Cdd:smart00255    2 YDVFISY-----SGKEDVRNEFLSHLLEKLRGYGL-CVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 924181709    948 FYLALQRLMDENMDVIIFILLEPVLQY--SQYLRLRqRICKSSILQWPNNPKAEnlFWQ 1004
Cdd:smart00255   76 LVAALENALEEGGLRVIPIFYEVIPSDvrKQPGKFR-KVFKKNYLKWPEDEKEQ--FWK 131
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
141-717 2.05e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.87  E-value: 2.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  141 LKELSLIQNNIFQVTKNNTFGLRNLERLYLGWNcyfkcNQTFKVEDGAFKNLIHLKVLSLSFNNLF-YVPPKLPSSLRKL 219
Cdd:PLN00113   71 VVSIDLSGKNISGKISSAIFRLPYIQTINLSNN-----QLSGPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETL 145
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  220 FLSNAKIMNITQEDFKGLENLTLLDLSGNCprcynapfpctpckenSSIHIhPLAFQSLTQLLYLNLSSTSLR-TIPSTw 298
Cdd:PLN00113  146 DLSNNMLSGEIPNDIGSFSSLKVLDLGGNV----------------LVGKI-PNSLTNLTSLEFLTLASNQLVgQIPRE- 207
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  299 FENLSNLKELHLEFNYLVQEIASGafLTKLPSLQILDLSFNfqykeylqfiNISSNF-SKLRSLKKLHlrgYVF---REL 374
Cdd:PLN00113  208 LGQMKSLKWIYLGYNNLSGEIPYE--IGGLTSLNHLDLVYN----------NLTGPIpSSLGNLKNLQ---YLFlyqNKL 272
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  375 KKKHFEHLQSLPNLATINLGINFIEKIDFKAFQNFSKLDVIYLSGNRIASVLDGTDYSS--------WRNRLRKPLSTDd 446
Cdd:PLN00113  273 SGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLprlqvlqlWSNKFSGEIPKN- 351
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  447 deFDPHVNFyhstkplikpqctaygKALDLSLNNI----------------FIIGKSQFEGfqDI-----ACLNLS-FNA 504
Cdd:PLN00113  352 --LGKHNNL----------------TVLDLSTNNLtgeipeglcssgnlfkLILFSNSLEG--EIpkslgACRSLRrVRL 411
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  505 NTQVFNG---TEFSSMPHIKYLDLTNNRLDFDDNNAFSDLHDLEVLDLSHNAHYfsiAGVTHRLGfiqnLINLRVLNLSH 581
Cdd:PLN00113  412 QDNSFSGelpSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFF---GGLPDSFG----SKRLENLDLSR 484
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  582 NGIYTLTEESELKSISLKELVFSGNRLdrlwnanDGKYWSIFKSLQNLIRLDLSYNNLqqipNGaflNLPQSLQEllisg 661
Cdd:PLN00113  485 NQFSGAVPRKLGSLSELMQLKLSENKL-------SGEIPDELSSCKKLVSLDLSHNQL----SG---QIPASFSE----- 545
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 924181709  662 nklrffnwtllqyFPHLHLLDLSRNELYF-LPNCLSKfAHSLETLLLSHNHF-SHLPS 717
Cdd:PLN00113  546 -------------MPVLSQLDLSQNQLSGeIPKNLGN-VESLVQVNISHNHLhGSLPS 589
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
264-760 1.01e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.94  E-value: 1.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  264 ENSSIHIHPLAFQsLTQLLYLNLSSTSLR-TIPSTWFENLSNLKELHLEFNYLVQEIASGAfltkLPSLQILDLSFNFQY 342
Cdd:PLN00113   79 KNISGKISSAIFR-LPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS----IPNLETLDLSNNMLS 153
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  343 KEY---------LQFINISSNF---------SKLRSLKKL-----HLRGYVFRELKKkhfehlqsLPNLATINLGINFIE 399
Cdd:PLN00113  154 GEIpndigsfssLKVLDLGGNVlvgkipnslTNLTSLEFLtlasnQLVGQIPRELGQ--------MKSLKWIYLGYNNLS 225
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  400 ---KIDFKAFQNFSKLDVIY--LSGNRIASVLDGTDYSS---WRNRLRKPLstdddefdPHVNFyhSTKPLIkpqctayg 471
Cdd:PLN00113  226 geiPYEIGGLTSLNHLDLVYnnLTGPIPSSLGNLKNLQYlflYQNKLSGPI--------PPSIF--SLQKLI-------- 287
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  472 kALDLSLNNIFIIGKSQFEGFQDIACLNLSFNANTQVFNGTeFSSMPHIKYLDLTNNRLDFDDNNAFSDLHDLEVLDLSH 551
Cdd:PLN00113  288 -SLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVA-LTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLST 365
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  552 NahyfSIAG-VTHRLGFIQNLINLRVLNLSHNGIY--TLTEESELKSISLKELVFSGnrldrlwnandgKYWSIFKSLQN 628
Cdd:PLN00113  366 N----NLTGeIPEGLCSSGNLFKLILFSNSLEGEIpkSLGACRSLRRVRLQDNSFSG------------ELPSEFTKLPL 429
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  629 LIRLDLSYNNLQ--------QIP---------NGAFLNLPQS-----LQELLISGNKLRFFNWTLLQYFPHLHLLDLSRN 686
Cdd:PLN00113  430 VYFLDISNNNLQgrinsrkwDMPslqmlslarNKFFGGLPDSfgskrLENLDLSRNQFSGAVPRKLGSLSELMQLKLSEN 509
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 924181709  687 ELY-FLPNCLSKfAHSLETLLLSHNHFS-HLPSGFlSEARNLVHLDLSFNTIK---MINKSSLQTKMKTNLSILELHGN 760
Cdd:PLN00113  510 KLSgEIPDELSS-CKKLVSLDLSHNQLSgQIPASF-SEMPVLSQLDLSQNQLSgeiPKNLGNVESLVQVNISHNHLHGS 586
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
105-249 2.05e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 2.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  105 NGMNITE-GALLSLRNLTVLLLEDNQLYTIPaGLP--ESLKELSLIQNNIfqvTK-NNTFGLRNLERLYLGwncyfkCNQ 180
Cdd:cd21340    10 NDKNITKiDNLSLCKNLKVLYLYDNKITKIE-NLEflTNLTHLYLQNNQI---EKiENLENLVNLKKLYLG------GNR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  181 TFKVEDgaFKNLIHLKVLSLSFNNLfyvPPKLP------------SSLRKLFLSNAKIMNItqEDFKGLENLTLLDLSGN 248
Cdd:cd21340    80 ISVVEG--LENLTNLEELHIENQRL---PPGEKltfdprslaalsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNN 152

                  .
gi 924181709  249 C 249
Cdd:cd21340   153 Q 153
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
871-982 5.26e-09

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 55.01  E-value: 5.26e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709   871 YISYDTKDASVTDWVINELryhleesEDKSVLLCLEERDWDPGLPIIDNLMQSINQSKKTIFVLTKKYAKSWNFKTAFYL 950
Cdd:pfam13676    2 FISYAGEDRAWAEWLADAL-------EAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEA 74
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 924181709   951 ALQRLMDENmdVIIFILLE-----PVLQYSQYLRLRQ 982
Cdd:pfam13676   75 ALADPEGRK--RLIPVRLEcdlelPGLAGLQYIDLRD 109
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
543-762 2.34e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 53.90  E-value: 2.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  543 DLEVLDLSHNAHYFSIAGVTHRLGFIQNLINLRVLNLSHNGIYTLTE---ESELKSISLKELVFSGNRLDrlwnanDGKY 619
Cdd:cd00116    52 SLKELCLSLNETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCgvlESLLRSSSLQELKLNNNGLG------DRGL 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  620 WSIFKSLQ----NLIRLDLSYNNLQQ---IPNGAFLNLPQSLQELLISGNKLRFFNWTLL----QYFPHLHLLDLSRNEL 688
Cdd:cd00116   126 RLLAKGLKdlppALEKLVLGRNRLEGascEALAKALRANRDLKELNLANNGIGDAGIRALaeglKANCNLEVLDLNNNGL 205
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  689 -----YFLPNCLSKFAhSLETLLLSHNHF-----SHLPSGFLSEARNLVHLDLSFNTIKMINKSSLQTKMKTNLSI--LE 756
Cdd:cd00116   206 tdegaSALAETLASLK-SLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLleLD 284

                  ....*.
gi 924181709  757 LHGNYF 762
Cdd:cd00116   285 LRGNKF 290
LRR_8 pfam13855
Leucine rich repeat;
597-664 3.15e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 3.15e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 924181709   597 SLKELVFSGNRLDRLwnandgkYWSIFKSLQNLIRLDLSYNNLQQIPNGAFLNLPqSLQELLISGNKL 664
Cdd:pfam13855    2 NLRSLDLSNNRLTSL-------DDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP-SLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
498-552 3.91e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 3.91e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 924181709   498 LNLSFNaNTQVFNGTEFSSMPHIKYLDLTNNRLDFDDNNAFSDLHDLEVLDLSHN 552
Cdd:pfam13855    6 LDLSNN-RLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
279-339 2.15e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 2.15e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 924181709   279 TQLLYLNLSSTSLRTIPSTWFENLSNLKELHLEFNYLvQEIASGAFlTKLPSLQILDLSFN 339
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL-TTLSPGAF-SGLPSLRYLDLSGN 59
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
529-788 2.53e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.92  E-value: 2.53e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  529 RLDFDDNNAFSDLHDLEVLDLSHNAhyfsiagVTHRLGFIQNLINLRVLNLSHNGIYTLTEE-SELKsiSLKELVFSGNR 607
Cdd:COG4886   100 ELDLSGNEELSNLTNLESLDLSGNQ-------LTDLPEELANLTNLKELDLSNNQLTDLPEPlGNLT--NLKSLDLSNNQ 170
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  608 LDRLWNAndgkywsiFKSLQNLIRLDLSYNNLQQIPNgAFLNLPqSLQELLISGNKLRFFNWTLLQyFPHLHLLDLSRNE 687
Cdd:COG4886   171 LTDLPEE--------LGNLTNLKELDLSNNQITDLPE-PLGNLT-NLEELDLSGNQLTDLPEPLAN-LTNLETLDLSNNQ 239
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  688 LYFLPNcLSKFaHSLETLLLSHNHFSHLPSgfLSEARNLVHLDLSFNTIKMINKSSLQTKMKTNLSILELHGNYFDCTCD 767
Cdd:COG4886   240 LTDLPE-LGNL-TNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315
                         250       260
                  ....*....|....*....|.
gi 924181709  768 ISDFRSWLDENLNITIPKLVN 788
Cdd:COG4886   316 LLLLLTTLLLLLLLLKGLLVT 336
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
63-481 6.55e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.21  E-value: 6.55e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709   63 TNIDLSDNAITHITKESFQKLQNLTKIDLNHNAKQQHPNENKNGMNITEGALLSLRNLTVLLLEDNQLYTIPA-GLPESL 141
Cdd:COG4886    19 ELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDlGDLTNL 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  142 KELSLIQNNIFqvtknntFGLRNLERLYLGWNcyfkcnqTFKVEDGAFKNLIHLKVLSLSFNNLFYVPPKLPS--SLRKL 219
Cdd:COG4886    99 TELDLSGNEEL-------SNLTNLESLDLSGN-------QLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNltNLKSL 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  220 FLSNAKIMNITQEdFKGLENLTLLDLSGNcprcynapfpctpckensSIHIHPLAFQSLTQLLYLNLSSTSLRTIPSTwF 299
Cdd:COG4886   165 DLSNNQLTDLPEE-LGNLTNLKELDLSNN------------------QITDLPEPLGNLTNLEELDLSGNQLTDLPEP-L 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  300 ENLSNLKELHLEFNylvqEIASGAFLTKLPSLQILDLSFNfqykeylQFINISSNfSKLRSLKKLHLRGYVFRELKKKHF 379
Cdd:COG4886   225 ANLTNLETLDLSNN----QLTDLPELGNLTNLEELDLSNN-------QLTDLPPL-ANLTNLKTLDLSNNQLTDLKLKEL 292
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  380 EHLQSLPNLATINLGINFIEKIDFKAFQNFSKLDVIYLSGNRIASVLDGTDYSSWRNRLRKPLSTDDDEFDPHVNFYHST 459
Cdd:COG4886   293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLL 372
                         410       420
                  ....*....|....*....|..
gi 924181709  460 KPLIKPQCTAYGKALDLSLNNI 481
Cdd:COG4886   373 GLLEATLLTLALLLLTLLLLLL 394
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
472-827 2.63e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 2.63e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  472 KALDLSLNNIFIIGKSQFEGFQDIACLNLSFNantqvfngTEFSSMPHIKYLDLTNNRLDfDDNNAFSDLHDLEVLDLSH 551
Cdd:COG4886    75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN--------EELSNLTNLESLDLSGNQLT-DLPEELANLTNLKELDLSN 145
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  552 NahyfsiaGVTHRLGFIQNLINLRVLNLSHNGIYTLTEE-SELKSisLKELVFSGNRLDRLWNAndgkywsiFKSLQNLI 630
Cdd:COG4886   146 N-------QLTDLPEPLGNLTNLKSLDLSNNQLTDLPEElGNLTN--LKELDLSNNQITDLPEP--------LGNLTNLE 208
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  631 RLDLSYNNLQQIPNgAFLNLPqSLQELLISGNKLRFFNWtlLQYFPHLHLLDLSRNELYFLPNCLSkfAHSLETLLLSHN 710
Cdd:COG4886   209 ELDLSGNQLTDLPE-PLANLT-NLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLAN--LTNLKTLDLSNN 282
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  711 HFSHLPSGFLSEARNLVHLDLSFNTIKMINKSSLQTKMKTNLSILELHGNYFDCTCDISDFRSWLDENLNITIPKLVNVI 790
Cdd:COG4886   283 QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLL 362
                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 924181709  791 CSNPGDQKSKSIMSLDLTTCVSDTTAAVLFFLTFLTT 827
Cdd:COG4886   363 LTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAG 399
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
101-552 5.56e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 5.56e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  101 NENKNGMNITEGALLSLRNLTVLLLEDNQLYTIPAGLPESLKELSLIQNNIFQVTKNNTFGLRNLERLYLGWNCYFKCN- 179
Cdd:COG4886     2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLl 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  180 -QTFKVEDGAFKNLIHLKVLSLSFNNLFYVPpklpSSLRKLFLSNAKIMNITqEDFKGLENLTLLDLSGNcprcynapfp 258
Cdd:COG4886    82 lSLLLLGLTDLGDLTNLTELDLSGNEELSNL----TNLESLDLSGNQLTDLP-EELANLTNLKELDLSNN---------- 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  259 ctpckensSIHIHPLAFQSLTQLLYLNLSSTSLRTIPStWFENLSNLKELHLEFNYLvQEIasGAFLTKLPSLQILDLSF 338
Cdd:COG4886   147 --------QLTDLPEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQI-TDL--PEPLGNLTNLEELDLSG 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  339 NfqykeylQFINISSNFSKLRSLKKLHLRGYVFRELkkkhfEHLQSLPNLATINLGINFIEKIDFKAfqNFSKLDVIYLS 418
Cdd:COG4886   215 N-------QLTDLPEPLANLTNLETLDLSNNQLTDL-----PELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLS 280
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  419 GNRIASVLDGTDYSSWRNRLRKPLSTDDDEFDPHVNFYHSTKPLIKpqctayGKALDLSLNNIFIIGKSQFEGFQDIACL 498
Cdd:COG4886   281 NNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLL------LLLLKGLLVTLTTLALSLSLLALLTLLL 354
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 924181709  499 NLSFNANTQVFNGTEFSSMPHIKYLDLTNNRLDFDDNNAFSDLHDLEVLDLSHN 552
Cdd:COG4886   355 LLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALL 408
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-415 2.29e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.51  E-value: 2.29e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709   55 PQTIGKYVTNIDLSDNAITHITKESFQKLQNLTKIDLNHNAkqqhpnenkngmnitegALLSLRNLTVLLLEDNQLYTIP 134
Cdd:COG4886    67 LLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-----------------ELSNLTNLESLDLSGNQLTDLP 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  135 AGLPEslkelsliqnnifqvtknntfgLRNLERLYLGWNcyfkcnqTFKVEDGAFKNLIHLKVLSLSFNNLFYVPPKLP- 213
Cdd:COG4886   130 EELAN----------------------LTNLKELDLSNN-------QLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGn 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  214 -SSLRKLFLSNAKIMNITQEdFKGLENLTLLDLSGNcprcynapfpctpckENSSIhihPLAFQSLTQLLYLNLSSTSLR 292
Cdd:COG4886   181 lTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGN---------------QLTDL---PEPLANLTNLETLDLSNNQLT 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  293 TIPstWFENLSNLKELHLEFNylvqEIASGAFLTKLPSLQILDLSFNFQYKEYLQFINISSNFSKLRSLKKLHLRGYVFR 372
Cdd:COG4886   242 DLP--ELGNLTNLEELDLSNN----QLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 924181709  373 ELKKKHFEHLQSLPNLATINLGINFIEKIDFKAFQNFSKLDVI 415
Cdd:COG4886   316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNL 358
TIR smart00255
Toll - interleukin 1 - resistance;
868-1004 3.12e-14

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 70.82  E-value: 3.12e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709    868 YDAYISYdtkdaSVTDWVINELRYHLEESEDKSVLlCLEERDWDPGLPIIDNLMQSINQSKKTIFVLTKKYAKSWNFKTA 947
Cdd:smart00255    2 YDVFISY-----SGKEDVRNEFLSHLLEKLRGYGL-CVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 924181709    948 FYLALQRLMDENMDVIIFILLEPVLQY--SQYLRLRqRICKSSILQWPNNPKAEnlFWQ 1004
Cdd:smart00255   76 LVAALENALEEGGLRVIPIFYEVIPSDvrKQPGKFR-KVFKKNYLKWPEDEKEQ--FWK 131
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
478-849 3.91e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.74  E-value: 3.91e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  478 LNNIFIIGKSQFEGFQDIACLNLSFNANTQVFNGTEFSSMPHIKYLDLTNNRLDFDDNNAFSDLHDLEVLDLSHNAHYFS 557
Cdd:COG4886     2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  558 IAGVTHRLGFIQNLINLRVLNLSHN-GIYTLTEESEL---------------KSISLKELVFSGNRLDRLWNAndgkyws 621
Cdd:COG4886    82 LSLLLLGLTDLGDLTNLTELDLSGNeELSNLTNLESLdlsgnqltdlpeelaNLTNLKELDLSNNQLTDLPEP------- 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  622 iFKSLQNLIRLDLSYNNLQQIPNgAFLNLPQsLQELLISGNKLRFFNWTLLQyFPHLHLLDLSRNELYFLPNCLSKFaHS 701
Cdd:COG4886   155 -LGNLTNLKSLDLSNNQLTDLPE-ELGNLTN-LKELDLSNNQITDLPEPLGN-LTNLEELDLSGNQLTDLPEPLANL-TN 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  702 LETLLLSHNHFSHLPSgfLSEARNLVHLDLSFNTIKMINKSSLqtkmKTNLSILELHGNYFDCTCDISDFRSWLDENLNI 781
Cdd:COG4886   230 LETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLAN----LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLL 303
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 924181709  782 TIPKLVNVICSNPGDQKSKSIMSLDLTTCVSDTTAAVLFFLTFLTTSMVMLAALVHHLFYWDVWFIYH 849
Cdd:COG4886   304 LLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGL 371
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
141-717 2.05e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.87  E-value: 2.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  141 LKELSLIQNNIFQVTKNNTFGLRNLERLYLGWNcyfkcNQTFKVEDGAFKNLIHLKVLSLSFNNLF-YVPPKLPSSLRKL 219
Cdd:PLN00113   71 VVSIDLSGKNISGKISSAIFRLPYIQTINLSNN-----QLSGPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETL 145
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  220 FLSNAKIMNITQEDFKGLENLTLLDLSGNCprcynapfpctpckenSSIHIhPLAFQSLTQLLYLNLSSTSLR-TIPSTw 298
Cdd:PLN00113  146 DLSNNMLSGEIPNDIGSFSSLKVLDLGGNV----------------LVGKI-PNSLTNLTSLEFLTLASNQLVgQIPRE- 207
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  299 FENLSNLKELHLEFNYLVQEIASGafLTKLPSLQILDLSFNfqykeylqfiNISSNF-SKLRSLKKLHlrgYVF---REL 374
Cdd:PLN00113  208 LGQMKSLKWIYLGYNNLSGEIPYE--IGGLTSLNHLDLVYN----------NLTGPIpSSLGNLKNLQ---YLFlyqNKL 272
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  375 KKKHFEHLQSLPNLATINLGINFIEKIDFKAFQNFSKLDVIYLSGNRIASVLDGTDYSS--------WRNRLRKPLSTDd 446
Cdd:PLN00113  273 SGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLprlqvlqlWSNKFSGEIPKN- 351
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  447 deFDPHVNFyhstkplikpqctaygKALDLSLNNI----------------FIIGKSQFEGfqDI-----ACLNLS-FNA 504
Cdd:PLN00113  352 --LGKHNNL----------------TVLDLSTNNLtgeipeglcssgnlfkLILFSNSLEG--EIpkslgACRSLRrVRL 411
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  505 NTQVFNG---TEFSSMPHIKYLDLTNNRLDFDDNNAFSDLHDLEVLDLSHNAHYfsiAGVTHRLGfiqnLINLRVLNLSH 581
Cdd:PLN00113  412 QDNSFSGelpSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFF---GGLPDSFG----SKRLENLDLSR 484
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  582 NGIYTLTEESELKSISLKELVFSGNRLdrlwnanDGKYWSIFKSLQNLIRLDLSYNNLqqipNGaflNLPQSLQEllisg 661
Cdd:PLN00113  485 NQFSGAVPRKLGSLSELMQLKLSENKL-------SGEIPDELSSCKKLVSLDLSHNQL----SG---QIPASFSE----- 545
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 924181709  662 nklrffnwtllqyFPHLHLLDLSRNELYF-LPNCLSKfAHSLETLLLSHNHF-SHLPS 717
Cdd:PLN00113  546 -------------MPVLSQLDLSQNQLSGeIPKNLGN-VESLVQVNISHNHLhGSLPS 589
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
264-760 1.01e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.94  E-value: 1.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  264 ENSSIHIHPLAFQsLTQLLYLNLSSTSLR-TIPSTWFENLSNLKELHLEFNYLVQEIASGAfltkLPSLQILDLSFNFQY 342
Cdd:PLN00113   79 KNISGKISSAIFR-LPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS----IPNLETLDLSNNMLS 153
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  343 KEY---------LQFINISSNF---------SKLRSLKKL-----HLRGYVFRELKKkhfehlqsLPNLATINLGINFIE 399
Cdd:PLN00113  154 GEIpndigsfssLKVLDLGGNVlvgkipnslTNLTSLEFLtlasnQLVGQIPRELGQ--------MKSLKWIYLGYNNLS 225
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  400 ---KIDFKAFQNFSKLDVIY--LSGNRIASVLDGTDYSS---WRNRLRKPLstdddefdPHVNFyhSTKPLIkpqctayg 471
Cdd:PLN00113  226 geiPYEIGGLTSLNHLDLVYnnLTGPIPSSLGNLKNLQYlflYQNKLSGPI--------PPSIF--SLQKLI-------- 287
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  472 kALDLSLNNIFIIGKSQFEGFQDIACLNLSFNANTQVFNGTeFSSMPHIKYLDLTNNRLDFDDNNAFSDLHDLEVLDLSH 551
Cdd:PLN00113  288 -SLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVA-LTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLST 365
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  552 NahyfSIAG-VTHRLGFIQNLINLRVLNLSHNGIY--TLTEESELKSISLKELVFSGnrldrlwnandgKYWSIFKSLQN 628
Cdd:PLN00113  366 N----NLTGeIPEGLCSSGNLFKLILFSNSLEGEIpkSLGACRSLRRVRLQDNSFSG------------ELPSEFTKLPL 429
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  629 LIRLDLSYNNLQ--------QIP---------NGAFLNLPQS-----LQELLISGNKLRFFNWTLLQYFPHLHLLDLSRN 686
Cdd:PLN00113  430 VYFLDISNNNLQgrinsrkwDMPslqmlslarNKFFGGLPDSfgskrLENLDLSRNQFSGAVPRKLGSLSELMQLKLSEN 509
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 924181709  687 ELY-FLPNCLSKfAHSLETLLLSHNHFS-HLPSGFlSEARNLVHLDLSFNTIK---MINKSSLQTKMKTNLSILELHGN 760
Cdd:PLN00113  510 KLSgEIPDELSS-CKKLVSLDLSHNQLSgQIPASF-SEMPVLSQLDLSQNQLSgeiPKNLGNVESLVQVNISHNHLHGS 586
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
105-249 2.05e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 2.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  105 NGMNITE-GALLSLRNLTVLLLEDNQLYTIPaGLP--ESLKELSLIQNNIfqvTK-NNTFGLRNLERLYLGwncyfkCNQ 180
Cdd:cd21340    10 NDKNITKiDNLSLCKNLKVLYLYDNKITKIE-NLEflTNLTHLYLQNNQI---EKiENLENLVNLKKLYLG------GNR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  181 TFKVEDgaFKNLIHLKVLSLSFNNLfyvPPKLP------------SSLRKLFLSNAKIMNItqEDFKGLENLTLLDLSGN 248
Cdd:cd21340    80 ISVVEG--LENLTNLEELHIENQRL---PPGEKltfdprslaalsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNN 152

                  .
gi 924181709  249 C 249
Cdd:cd21340   153 Q 153
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
270-715 3.50e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.33  E-value: 3.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  270 IHPLAFQSLTQLLYLNLSSTSLRTIPSTWFENLSNLKELHLEFNYLVQEIASGAFLTKLPSLQILDLSFNfqykeylqfi 349
Cdd:COG4886    37 LLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN---------- 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  350 nisSNFSKLRSLKKLHLRGYVFRELkkkhFEHLQSLPNLATINLGINFIEKIDfKAFQNFSKLDVIYLSGNRIASVldgt 429
Cdd:COG4886   107 ---EELSNLTNLESLDLSGNQLTDL----PEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDL---- 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  430 dysswrnrlrkplstdDDEFDPHVNFyhstkplikpqctaygKALDLSLNNIfiigksqfegfQDIaclnlsfnantqvf 509
Cdd:COG4886   175 ----------------PEELGNLTNL----------------KELDLSNNQI-----------TDL-------------- 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  510 nGTEFSSMPHIKYLDLTNNRLDfDDNNAFSDLHDLEVLDLSHNAhyfsiagVTHrLGFIQNLINLRVLNLSHNGIYTLTE 589
Cdd:COG4886   198 -PEPLGNLTNLEELDLSGNQLT-DLPEPLANLTNLETLDLSNNQ-------LTD-LPELGNLTNLEELDLSNNQLTDLPP 267
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  590 ESELKsiSLKELVFSGNRLDRLWNANDGKYWSIFKSLQNLIRLDLSYNNLQQIPNGAFLNLPQSLQELLISGNKLRFFNW 669
Cdd:COG4886   268 LANLT--NLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLS 345
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 924181709  670 TLLQYFPHLHLLDLSRNELYFLPNCLSKFAHSLETLLLSHNHFSHL 715
Cdd:COG4886   346 LLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLL 391
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
47-231 3.89e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 60.87  E-value: 3.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709   47 NHRQLHEVPQTIGKYVTNIDLSDNAITHITKESFQKLQNLtkiDLNHNAKQQHPNenkngmNITEGallsLRNLTVLlle 126
Cdd:PRK15370  228 NSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQSL---DLFHNKISCLPE------NLPEE----LRYLSVY--- 291
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  127 DNQLYTIPAGLPESLKELSLIQNNIFQVTKNNTFGLRNLErlylgwncyfkcnqtfkVEDGAFKNL-----IHLKVLSLS 201
Cdd:PRK15370  292 DNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPGLKTLE-----------------AGENALTSLpaslpPELQVLDVS 354
                         170       180       190
                  ....*....|....*....|....*....|
gi 924181709  202 FNNLFYVPPKLPSSLRKLFLSNAKIMNITQ 231
Cdd:PRK15370  355 KNQITVLPETLPPTITTLDVSRNALTNLPE 384
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
871-982 5.26e-09

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 55.01  E-value: 5.26e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709   871 YISYDTKDASVTDWVINELryhleesEDKSVLLCLEERDWDPGLPIIDNLMQSINQSKKTIFVLTKKYAKSWNFKTAFYL 950
Cdd:pfam13676    2 FISYAGEDRAWAEWLADAL-------EAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEA 74
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 924181709   951 ALQRLMDENmdVIIFILLE-----PVLQYSQYLRLRQ 982
Cdd:pfam13676   75 ALADPEGRK--RLIPVRLEcdlelPGLAGLQYIDLRD 109
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
868-986 5.42e-09

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 56.22  E-value: 5.42e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709   868 YDAYISYDTKDasVTDWVINELRYHLEEsedKSVLLCLEERDWDPGLPIIDNLMQSINQSKKTIFVLTKKYAKS-WN--- 943
Cdd:pfam01582    1 YDVFLSFRGSD--TREWFVSHLLKELKQ---KGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSgWClde 75
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 924181709   944 FKTAFYLALQRLMdenmdVIIFILLEPVLQYSQ-----YLRLRQRICK 986
Cdd:pfam01582   76 LVKILECALDLGQ-----KVIPIFYEVDPSDVRkqtgsFGKAFKKHKK 118
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
46-356 8.54e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.71  E-value: 8.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709   46 CNHRQLHEVPQTIGKYV--TNIDLSDNAITHITkESFQKLQNLTKIDLNHNakqqhpnenkngmNITE--GALLSLRNLT 121
Cdd:COG4886   143 LSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN-------------QITDlpEPLGNLTNLE 208
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  122 VLLLEDNQLYTIPAGLPeslkelsliqnnifqvtknntfGLRNLERLYLGWNcyfkcnqtfKVED-GAFKNLIHLKVLSL 200
Cdd:COG4886   209 ELDLSGNQLTDLPEPLA----------------------NLTNLETLDLSNN---------QLTDlPELGNLTNLEELDL 257
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  201 SFNNLFYVPPKLP-SSLRKLFLSNAKIMNITQEDFKGLENLTLLDLSGNcpRCYNAPFPCTPCKENSSIHIHPLAFQSLT 279
Cdd:COG4886   258 SNNQLTDLPPLANlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL--LLNLLELLILLLLLTTLLLLLLLLKGLLV 335
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 924181709  280 QLLYLNLSSTSLRTIPSTWFENLSNLKELHLEFNYLVQEIASGAFLTKLPSLQILDLSFNFQYKEYLQFINISSNFS 356
Cdd:COG4886   336 TLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
29-249 2.22e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 53.90  E-value: 2.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709   29 RSYPCDEIRHNSLVIAECNHRQLHEVPQTIGKYV--TNIDLSDNAITHITKESFQKLQ---NLTKIDLNHNAkqqhpnEN 103
Cdd:cd00116    48 RPQPSLKELCLSLNETGRIPRGLQSLLQGLTKGCglQELDLSDNALGPDGCGVLESLLrssSLQELKLNNNG------LG 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  104 KNGMNITEGALLSLR-NLTVLLLEDNQLY---TIPAG--LPE--SLKELSLIQNNIfqvtknNTFGLR----------NL 165
Cdd:cd00116   122 DRGLRLLAKGLKDLPpALEKLVLGRNRLEgasCEALAkaLRAnrDLKELNLANNGI------GDAGIRalaeglkancNL 195
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  166 ERLYLgWNCYFKCNQTFKVEdGAFKNLIHLKVLSLSFNNLFYVP--------PKLPSSLRKLFLSNAKimnITQEDFKGL 237
Cdd:cd00116   196 EVLDL-NNNGLTDEGASALA-ETLASLKSLEVLNLGDNNLTDAGaaalasalLSPNISLLTLSLSCND---ITDDGAKDL 270
                         250
                  ....*....|....*....
gi 924181709  238 -------ENLTLLDLSGNC 249
Cdd:cd00116   271 aevlaekESLLELDLRGNK 289
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
543-762 2.34e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 53.90  E-value: 2.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  543 DLEVLDLSHNAHYFSIAGVTHRLGFIQNLINLRVLNLSHNGIYTLTE---ESELKSISLKELVFSGNRLDrlwnanDGKY 619
Cdd:cd00116    52 SLKELCLSLNETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCgvlESLLRSSSLQELKLNNNGLG------DRGL 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  620 WSIFKSLQ----NLIRLDLSYNNLQQ---IPNGAFLNLPQSLQELLISGNKLRFFNWTLL----QYFPHLHLLDLSRNEL 688
Cdd:cd00116   126 RLLAKGLKdlppALEKLVLGRNRLEGascEALAKALRANRDLKELNLANNGIGDAGIRALaeglKANCNLEVLDLNNNGL 205
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  689 -----YFLPNCLSKFAhSLETLLLSHNHF-----SHLPSGFLSEARNLVHLDLSFNTIKMINKSSLQTKMKTNLSI--LE 756
Cdd:cd00116   206 tdegaSALAETLASLK-SLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLleLD 284

                  ....*.
gi 924181709  757 LHGNYF 762
Cdd:cd00116   285 LRGNKF 290
LRR_8 pfam13855
Leucine rich repeat;
597-664 3.15e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 3.15e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 924181709   597 SLKELVFSGNRLDRLwnandgkYWSIFKSLQNLIRLDLSYNNLQQIPNGAFLNLPqSLQELLISGNKL 664
Cdd:pfam13855    2 NLRSLDLSNNRLTSL-------DDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP-SLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
65-582 3.48e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.47  E-value: 3.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709   65 IDLSDNAITHITKESFQKLQNLTKIDLNHNAKQQHpnenkngmniTEGALLSLRNLTVLLLEDNQLYtipAGLPESLKEL 144
Cdd:PLN00113  145 LDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGK----------IPNSLTNLTSLEFLTLASNQLV---GQIPRELGQM 211
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  145 sliqnnifqvtknntfglRNLERLYLGWNcyfKCNQTFKVEDGAFKNLIHLkvlSLSFNNLF-YVPPKLP--SSLRKLFL 221
Cdd:PLN00113  212 ------------------KSLKWIYLGYN---NLSGEIPYEIGGLTSLNHL---DLVYNNLTgPIPSSLGnlKNLQYLFL 267
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  222 SNAKIMNITQEDFKGLENLTLLDLSGNcprcynapfpctpckeNSSIHIHPLAFQsLTQLLYLNLSSTSLR-TIPSTwFE 300
Cdd:PLN00113  268 YQNKLSGPIPPSIFSLQKLISLDLSDN----------------SLSGEIPELVIQ-LQNLEILHLFSNNFTgKIPVA-LT 329
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  301 NLSNLKELHLEFNYLVQEIAsgAFLTKLPSLQILDLSFNFQYKEYLQFINISSNFSKLrSLKKLHLRGyvfrELKKKhfe 380
Cdd:PLN00113  330 SLPRLQVLQLWSNKFSGEIP--KNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKL-ILFSNSLEG----EIPKS--- 399
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  381 hLQSLPNLATINLGINfieKIDFKAFQNFSKLDVIY---LSGNRIASVLDGtdySSWRNRLRKPLSTDDDEFDPHVNFYH 457
Cdd:PLN00113  400 -LGACRSLRRVRLQDN---SFSGELPSEFTKLPLVYfldISNNNLQGRINS---RKWDMPSLQMLSLARNKFFGGLPDSF 472
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  458 STKPLikpqctaygKALDLSLNNIFIIGKSQFEGFQDIACLNLSFNANTQVFNgTEFSSMPHIKYLDLTNNRLDFDDNNA 537
Cdd:PLN00113  473 GSKRL---------ENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIP-DELSSCKKLVSLDLSHNQLSGQIPAS 542
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 924181709  538 FSDLHDLEVLDLSHNahyfSIAG-VTHRLGFIQNLINlrvLNLSHN 582
Cdd:PLN00113  543 FSEMPVLSQLDLSQN----QLSGeIPKNLGNVESLVQ---VNISHN 581
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
118-339 3.57e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 54.32  E-value: 3.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  118 RNLTVLLLEDNQLYTIPAGLPESLKELSLIQNNIFQVTKNntfgLR-NLERLYLGWNCYFKCNQTFKVEdgafknlihLK 196
Cdd:PRK15370  178 NNKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPEN----LQgNIKTLYANSNQLTSIPATLPDT---------IQ 244
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  197 VLSLSFNNLFYVPPKLPSSLRKLFLSNAKIMNITQEDFKGLENLTLLDlsgNCPRCYNAPFPctpckenSSIhihplafq 276
Cdd:PRK15370  245 EMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYD---NSIRTLPAHLP-------SGI-------- 306
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 924181709  277 sltqlLYLNLSSTSLRTIPSTWFENLSNLkelhlefnylvqeIASGAFLTKL-----PSLQILDLSFN 339
Cdd:PRK15370  307 -----THLNVQSNSLTALPETLPPGLKTL-------------EAGENALTSLpaslpPELQVLDVSKN 356
LRR_8 pfam13855
Leucine rich repeat;
498-552 3.91e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 3.91e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 924181709   498 LNLSFNaNTQVFNGTEFSSMPHIKYLDLTNNRLDFDDNNAFSDLHDLEVLDLSHN 552
Cdd:pfam13855    6 LDLSNN-RLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
39-214 4.46e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.93  E-value: 4.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709   39 NSLVIAECNHRQLHEVPQTIGKYVTNIDLSDNAITHITKESFQKLQNLTKIDLNHNAKQQHPNENKNGMNITEGALLSL- 117
Cdd:PRK15370  241 DTIQEMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALp 320
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  118 ----RNLTVLLLEDNQLYTIPAGLPESLKELSLIQNNIFQVTKNNTFGLrnlerlylgwncyfkcnQTFKVEDGAFKNLI 193
Cdd:PRK15370  321 etlpPGLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPETLPPTI-----------------TTLDVSRNALTNLP 383
                         170       180
                  ....*....|....*....|....*.
gi 924181709  194 H-----LKVLSLSFNNLFYVPPKLPS 214
Cdd:PRK15370  384 EnlpaaLQIMQASRNNLVRLPESLPH 409
LRR_8 pfam13855
Leucine rich repeat;
627-688 5.73e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 5.73e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 924181709   627 QNLIRLDLSYNNLQQIPNGAFLNLPqSLQELLISGNKLRFFNWTLLQYFPHLHLLDLSRNEL 688
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLS-NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
119-317 8.59e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.16  E-value: 8.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  119 NLTVLLLEDNQLYTIPAGLPESLKELSLIQNNIFQVTKNNTFGLRNLErlylgwncyFKCNQTFKVEDgafkNLIH-LKV 197
Cdd:PRK15370  221 NIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQSLD---------LFHNKISCLPE----NLPEeLRY 287
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  198 LSLSFNNLFYVPPKLPSSLRKLFLSNAKIMNITQEDFKGLENLTLLDlsgNCPRCYNAPFPctPCKENSS-----IHIHP 272
Cdd:PRK15370  288 LSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPGLKTLEAGE---NALTSLPASLP--PELQVLDvsknqITVLP 362
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 924181709  273 LAFQSLTQLLYlnLSSTSLRTIPstwfENL-SNLKELHLEFNYLVQ 317
Cdd:PRK15370  363 ETLPPTITTLD--VSRNALTNLP----ENLpAALQIMQASRNNLVR 402
LRR_8 pfam13855
Leucine rich repeat;
279-339 2.15e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 2.15e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 924181709   279 TQLLYLNLSSTSLRTIPSTWFENLSNLKELHLEFNYLvQEIASGAFlTKLPSLQILDLSFN 339
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL-TTLSPGAF-SGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
568-760 2.46e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 2.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  568 IQNLI---NLRVLNLSHNGIYTLTEESELKSisLKELVFSGNRLDRLWNandgkywsiFKSLQNLIRLDLSYNNLQQIPN 644
Cdd:cd21340    17 IDNLSlckNLKVLYLYDNKITKIENLEFLTN--LTHLYLQNNQIEKIEN---------LENLVNLKKLYLGGNRISVVEG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  645 gafLNLPQSLQELLISGNKLRffnwtllqyfphlhlldlSRNELYFLPNCLSKFAHSLETLLLSHNHFSHLpsGFLSEAR 724
Cdd:cd21340    86 ---LENLTNLEELHIENQRLP------------------PGEKLTFDPRSLAALSNSLRVLNISGNNIDSL--EPLAPLR 142
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 924181709  725 NLVHLDLSFNTIKMINKSSLQTKMKTNLSILELHGN 760
Cdd:cd21340   143 NLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
62-130 4.81e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 4.81e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 924181709    62 VTNIDLSDNAITHITKESFQKLQNLTKIDLNHNAKQQhpnenkngmnITEGALLSLRNLTVLLLEDNQL 130
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT----------LSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
269-315 5.05e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 5.05e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 924181709   269 HIHPLAFQSLTQLLYLNLSSTSLRTIPSTWFENLSNLKELHLEFNYL 315
Cdd:pfam13855   15 SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
518-584 5.41e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 5.41e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 924181709   518 PHIKYLDLTNNRLDFDDNNAFSDLHDLEVLDLSHNahyfSIAGVthRLGFIQNLINLRVLNLSHNGI 584
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN----LLTTL--SPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
215-368 1.60e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.09  E-value: 1.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  215 SLRKLFLSNAKIMNItqEDFKGLENLTLLDLSGNCPRCYnapfpctpckENssihihplaFQSLTQLLYLNLSSTSLRTI 294
Cdd:cd21340    25 NLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKI----------EN---------LENLVNLKKLYLGGNRISVV 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  295 PStwFENLSNLKELHLEFnylvQEIASGAFLTKLP--------SLQILDLSFN-------FQYKEYLQFINISSN----- 354
Cdd:cd21340    84 EG--LENLTNLEELHIEN----QRLPPGEKLTFDPrslaalsnSLRVLNISGNnidslepLAPLRNLEQLDASNNqisdl 157
                         170       180
                  ....*....|....*....|
gi 924181709  355 ------FSKLRSLKKLHLRG 368
Cdd:cd21340   158 eelldlLSSWPSLRELDLTG 177
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
627-764 2.15e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.54  E-value: 2.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  627 QNLIRLDLSYNNLQQIPNgaflNLPQSLQELLISGNKLRFFNWTLlqyfPH-LHLLDLSRNELYFLPNCLSKfahSLETL 705
Cdd:PRK15370  199 EQITTLILDNNELKSLPE----NLQGNIKTLYANSNQLTSIPATL----PDtIQEMELSINRITELPERLPS---ALQSL 267
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 924181709  706 LLSHNHFSHLPSGFLSEARNL-----------VHLDLSFNTIKMINKS--SLQTKMKTNLSILELHGNYFDC 764
Cdd:PRK15370  268 DLFHNKISCLPENLPEELRYLsvydnsirtlpAHLPSGITHLNVQSNSltALPETLPPGLKTLEAGENALTS 339
LRR_8 pfam13855
Leucine rich repeat;
163-248 7.44e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 7.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709   163 RNLERLYLGwncyfkCNQTFKVEDGAFKNLIHLKVLSLSFNNLFYVPPklpsslrklflsnakimnitqEDFKGLENLTL 242
Cdd:pfam13855    1 PNLRSLDLS------NNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSP---------------------GAFSGLPSLRY 53

                   ....*.
gi 924181709   243 LDLSGN 248
Cdd:pfam13855   54 LDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
514-662 7.72e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.16  E-value: 7.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  514 FSSMPHIKYLDLTNNRLDFDDNnaFSDLHDLEVLDLSHNahyfSIAgvthRLGFIQNLINLRVLNLSHNgiyTLTEESEL 593
Cdd:cd21340    42 LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGN----RIS----VVEGLENLTNLEELHIENQ---RLPPGEKL 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  594 -------KSI--SLKELVFSGNRLDRLwnandgkywSIFKSLQNLIRLDLSYNNLQQIPN--GAFLNLPQsLQELLISGN 662
Cdd:cd21340   109 tfdprslAALsnSLRVLNISGNNIDSL---------EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPS-LRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
214-291 9.71e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 9.71e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 924181709   214 SSLRKLFLSNAKIMNITQEDFKGLENLTLLDLSGNCPRcynapfpctpckenssiHIHPLAFQSLTQLLYLNLSSTSL 291
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT-----------------TLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
345-528 1.86e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.01  E-value: 1.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  345 YLQFINISS--NFSKLRSLKKLHLRGYVFRELkkkhfEHLQSLPNLATINLGINFIEKIDFkaFQNFSKLDVIYLSGNRI 422
Cdd:cd21340     8 YLNDKNITKidNLSLCKNLKVLYLYDNKITKI-----ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  423 aSVLDGTDYSSW-------RNRLRKPLSTdddEFDPHVNFYHSTKPLIkpqctaygkaLDLSLNNIFIIgkSQFEGFQDI 495
Cdd:cd21340    81 -SVVEGLENLTNleelhieNQRLPPGEKL---TFDPRSLAALSNSLRV----------LNISGNNIDSL--EPLAPLRNL 144
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 924181709  496 ACLNLSFNantQVFNGTE----FSSMPHIKYLDLTNN 528
Cdd:cd21340   145 EQLDASNN---QISDLEElldlLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
359-422 2.72e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 2.72e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 924181709   359 RSLKKLHLRGYVFRELKKKHFEHLqslPNLATINLGINFIEKIDFKAFQNFSKLDVIYLSGNRI 422
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGL---SNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
571-758 5.59e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 43.63  E-value: 5.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  571 LINLRVLNLSHNGIYTLTEESElKSISLKELVFSGNRLDrlwnaNDGKYwSIFKSLQNLIR---LDLSYNnlqQIPNGAF 647
Cdd:COG5238   184 TVYLGCNQIGDEGIEELAEALT-QNTTVTTLWLKRNPIG-----DEGAE-ILAEALKGNKSlttLDLSNN---QIGDEGV 253
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  648 LNLPQSLQE------LLISGNKL-----RFFNwTLLQYFPHLHLLDLSRNELYF-----LPNCLSKfAHSLETLLLSHNH 711
Cdd:COG5238   254 IALAEALKNnttvetLYLSGNQIgaegaIALA-KALQGNTTLTSLDLSVNRIGDegaiaLAEGLQG-NKTLHTLNLAYNG 331
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 924181709  712 FSHLPSGFLSEA----RNLVHLDLSFNTIKMINKSSLQTKMKTNLSILELH 758
Cdd:COG5238   332 IGAQGAIALAKAlqenTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELN 382
LRR_8 pfam13855
Leucine rich repeat;
474-530 1.08e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 1.08e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 924181709   474 LDLSLNNIFIIGKSQFEGFQDIACLNLSFNaNTQVFNGTEFSSMPHIKYLDLTNNRL 530
Cdd:pfam13855    6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNN-LLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
303-368 1.52e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 1.52e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 924181709   303 SNLKELHLEFNYLvQEIASGAFlTKLPSLQILDLSFNfqykeYLQFINISSnFSKLRSLKKLHLRG 368
Cdd:pfam13855    1 PNLRSLDLSNNRL-TSLDDGAF-KGLSNLKVLDLSNN-----LLTTLSPGA-FSGLPSLRYLDLSG 58
LRR_8 pfam13855
Leucine rich repeat;
676-734 1.63e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 1.63e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 924181709   676 PHLHLLDLSRNELYFLPNCLSKFAHSLETLLLSHNHFSHLPSGFLSEARNLVHLDLSFN 734
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
63-203 2.80e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.54  E-value: 2.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709   63 TNIDLSDNAITHItkESFQKLQNLTKIDLNHNakqqhpnenkngmNIT--EGaLLSLRNLTVLLLEDNQL---------- 130
Cdd:cd21340    49 THLYLQNNQIEKI--ENLENLVNLKKLYLGGN-------------RISvvEG-LENLTNLEELHIENQRLppgekltfdp 112
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 924181709  131 YTIpAGLPESLKELSLIQNNIfqVTKNNTFGLRNLERLYLGWNCYfkcnQTFKVEDGAFKNLIHLKVLSLSFN 203
Cdd:cd21340   113 RSL-AALSNSLRVLNISGNNI--DSLEPLAPLRNLEQLDASNNQI----SDLEELLDLLSSWPSLRELDLTGN 178
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
515-664 5.44e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.03  E-value: 5.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  515 SSMPHIKYLDLTNNRLD----FDDNNAFSDLHDLEVLDLSHNAhyFSIAGVTHRLGFIQNLINLRVLNLSHNGIytlTEE 590
Cdd:cd00116   134 DLPPALEKLVLGRNRLEgascEALAKALRANRDLKELNLANNG--IGDAGIRALAEGLKANCNLEVLDLNNNGL---TDE 208
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  591 -----SE-LKS-ISLKELVFSGNRLDrlwNANDGKYWSIFKSL-QNLIRLDLSYNNLQQIPNGAFLN-LPQ--SLQELLI 659
Cdd:cd00116   209 gasalAEtLASlKSLEVLNLGDNNLT---DAGAAALASALLSPnISLLTLSLSCNDITDDGAKDLAEvLAEkeSLLELDL 285

                  ....*
gi 924181709  660 SGNKL 664
Cdd:cd00116   286 RGNKF 290
LRR_8 pfam13855
Leucine rich repeat;
701-762 6.23e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 6.23e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 924181709   701 SLETLLLSHNHFSHLPSGFLSEARNLVHLDLSFNTIKMINKSSLQtKMKtNLSILELHGNYF 762
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFS-GLP-SLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
274-425 8.65e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 8.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  274 AFQSLTQLLYLNLSSTSLRTIPSTWFENL---SNLKELHLEFNYLvqEIASGAFLTK-----LPSLQILDLSFNFQYKEY 345
Cdd:cd00116    76 GLTKGCGLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGL--GDRGLRLLAKglkdlPPALEKLVLGRNRLEGAS 153
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924181709  346 LqfINISSNFSKLRSLKKLHL-----RGYVFRELkkkhFEHLQSLPNLATINLGINFIEKIDFKA----FQNFSKLDVIY 416
Cdd:cd00116   154 C--EALAKALRANRDLKELNLanngiGDAGIRAL----AEGLKANCNLEVLDLNNNGLTDEGASAlaetLASLKSLEVLN 227

                  ....*....
gi 924181709  417 LSGNRIASV 425
Cdd:cd00116   228 LGDNNLTDA 236
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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