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Conserved domains on  [gi|924182698|ref|NP_001300690|]
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toll-like receptor 8 isoform 3 [Mus musculus]

Protein Classification

toll-like receptor( domain architecture ID 11471630)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

CATH:  3.40.50.10140|3.80.10.10
Gene Ontology:  GO:0005515|GO:0002224|GO:0006955|GO:0004888|GO:0038187
PubMed:  18227810|16675322|34199501|16822173|11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
13-272 5.64e-20

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.30  E-value: 5.64e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698  13 RLDFDDNNAFSDLHDLEVLDLSHNAhyfsiagVTHRLGFIQNLINLRVLNLSHNGIYTLTEE-SELKsiSLKELVFSGNR 91
Cdd:COG4886  100 ELDLSGNEELSNLTNLESLDLSGNQ-------LTDLPEELANLTNLKELDLSNNQLTDLPEPlGNLT--NLKSLDLSNNQ 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698  92 LDRLWNAndgkywsiFKSLQNLIRLDLSYNNLQQIPNgAFLNLPqSLQELLISGNKLRFFNWTLLQyFPHLHLLDLSRNE 171
Cdd:COG4886  171 LTDLPEE--------LGNLTNLKELDLSNNQITDLPE-PLGNLT-NLEELDLSGNQLTDLPEPLAN-LTNLETLDLSNNQ 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698 172 LYFLPNcLSKFaHSLETLLLSHNHFSHLPSgfLSEARNLVHLDLSFNTIKMINKSSLQTKMKTNLSILELHGNYFDCTCD 251
Cdd:COG4886  240 LTDLPE-LGNL-TNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315

                        250       260
                 ....*....|....*....|.
gi 924182698 252 ISDFRSWLDENLNITIPKLVN 272
Cdd:COG4886  316 LLLLLTTLLLLLLLLKGLLVT 336
TIR smart00255
Toll - interleukin 1 - resistance;
352-488 3.63e-14

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 69.66  E-value: 3.63e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698   352 YDAYISYdtkdaSVTDWVINELRYHLEESEDKSVLlCLEERDWDPGLPIIDNLMQSINQSKKTIFVLTKKYAKSWNFKTA 431
Cdd:smart00255   2 YDVFISY-----SGKEDVRNEFLSHLLEKLRGYGL-CVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 924182698   432 FYLALQRLMDENMDVIIFILLEPVLQY--SQYLRLRqRICKSSILQWPNNPKAEnlFWQ 488
Cdd:smart00255  76 LVAALENALEEGGLRVIPIFYEVIPSDvrKQPGKFR-KVFKKNYLKWPEDEKEQ--FWK 131
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
13-272 5.64e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.30  E-value: 5.64e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698  13 RLDFDDNNAFSDLHDLEVLDLSHNAhyfsiagVTHRLGFIQNLINLRVLNLSHNGIYTLTEE-SELKsiSLKELVFSGNR 91
Cdd:COG4886  100 ELDLSGNEELSNLTNLESLDLSGNQ-------LTDLPEELANLTNLKELDLSNNQLTDLPEPlGNLT--NLKSLDLSNNQ 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698  92 LDRLWNAndgkywsiFKSLQNLIRLDLSYNNLQQIPNgAFLNLPqSLQELLISGNKLRFFNWTLLQyFPHLHLLDLSRNE 171
Cdd:COG4886  171 LTDLPEE--------LGNLTNLKELDLSNNQITDLPE-PLGNLT-NLEELDLSGNQLTDLPEPLAN-LTNLETLDLSNNQ 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698 172 LYFLPNcLSKFaHSLETLLLSHNHFSHLPSgfLSEARNLVHLDLSFNTIKMINKSSLQTKMKTNLSILELHGNYFDCTCD 251
Cdd:COG4886  240 LTDLPE-LGNL-TNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315

                        250       260
                 ....*....|....*....|.
gi 924182698 252 ISDFRSWLDENLNITIPKLVN 272
Cdd:COG4886  316 LLLLLTTLLLLLLLLKGLLVT 336
TIR smart00255
Toll - interleukin 1 - resistance;
352-488 3.63e-14

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 69.66  E-value: 3.63e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698   352 YDAYISYdtkdaSVTDWVINELRYHLEESEDKSVLlCLEERDWDPGLPIIDNLMQSINQSKKTIFVLTKKYAKSWNFKTA 431
Cdd:smart00255   2 YDVFISY-----SGKEDVRNEFLSHLLEKLRGYGL-CVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 924182698   432 FYLALQRLMDENMDVIIFILLEPVLQY--SQYLRLRqRICKSSILQWPNNPKAEnlFWQ 488
Cdd:smart00255  76 LVAALENALEEGGLRVIPIFYEVIPSDvrKQPGKFR-KVFKKNYLKWPEDEKEQ--FWK 131
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 352-470 4.09e-09

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 55.83  E-value: 4.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698  352 YDAYISYDTKDasVTDWVINELRYHLEEsedKSVLLCLEERDWDPGLPIIDNLMQSINQSKKTIFVLTKKYAKS-WN--- 427
Cdd:pfam01582   1 YDVFLSFRGSD--TREWFVSHLLKELKQ---KGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSgWClde 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 924182698  428 FKTAFYLALQRLMdenmdVIIFILLEPVLQYSQ-----YLRLRQRICK 470
Cdd:pfam01582  76 LVKILECALDLGQ-----KVIPIFYEVDPSDVRkqtgsFGKAFKKHKK 118
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 1-244 7.85e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.24  E-value: 7.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698   1 MPHIKYLDLTNNRLDFDDNNAFSDLHDLEVLDLSHNAhyFSiAGVTHRLGfIQNliNLRVLNLSHNGIYTLTEESELKSI 80
Cdd:PLN00113 307 LQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNK--FS-GEIPKNLG-KHN--NLTVLDLSTNNLTGEIPEGLCSSG 380

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698  81 SLKELVFSGNRLD----------------RLW-NANDGKYWSIFKSLQNLIRLDLSYNNLQ--------QIP-------- 127
Cdd:PLN00113 381 NLFKLILFSNSLEgeipkslgacrslrrvRLQdNSFSGELPSEFTKLPLVYFLDISNNNLQgrinsrkwDMPslqmlsla 460

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698 128 -NGAFLNLPQS-----LQELLISGNKLRFFNWTLLQYFPHLHLLDLSRNELY-FLPNCLSKfAHSLETLLLSHNHFS-HL 199
Cdd:PLN00113 461 rNKFFGGLPDSfgskrLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSS-CKKLVSLDLSHNQLSgQI 539

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 924182698 200 PSGFlSEARNLVHLDLSFNTIK---MINKSSLQTKMKTNLSILELHGN 244
Cdd:PLN00113 540 PASF-SEMPVLSQLDLSQNQLSgeiPKNLGNVESLVQVNISHNHLHGS 586
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 27-246 9.25e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 53.90  E-value: 9.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698  27 DLEVLDLSHNAHYFSIAGVTHRLGFIQNLINLRVLNLSHNGIYTLTE---ESELKSISLKELVFSGNRLDrlwnanDGKY 103
Cdd:cd00116   52 SLKELCLSLNETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCgvlESLLRSSSLQELKLNNNGLG------DRGL 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698 104 WSIFKSLQ----NLIRLDLSYNNLQQ---IPNGAFLNLPQSLQELLISGNKLRFFNWTLL----QYFPHLHLLDLSRNEL 172
Cdd:cd00116  126 RLLAKGLKdlppALEKLVLGRNRLEGascEALAKALRANRDLKELNLANNGIGDAGIRALaeglKANCNLEVLDLNNNGL 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698 173 -----YFLPNCLSKFAhSLETLLLSHNHF-----SHLPSGFLSEARNLVHLDLSFNTIKMINKSSLQTKMKTNLSI--LE 240
Cdd:cd00116  206 tdegaSALAETLASLK-SLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLleLD 284


                 ....*.
gi 924182698 241 LHGNYF 246
Cdd:cd00116  285 LRGNKF 290
LRR_8 pfam13855
Leucine rich repeat;
81-148 2.22e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 2.22e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 924182698   81 SLKELVFSGNRLDRLwnandgkYWSIFKSLQNLIRLDLSYNNLQQIPNGAFLNLPqSLQELLISGNKL 148
Cdd:pfam13855   2 NLRSLDLSNNRLTSL-------DDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP-SLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 214-297 2.30e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 40.84  E-value: 2.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698   214 DLSFNTIKMINKSSLQTKMktNLSILELHGNYFDCTCDISDFRSWLDENlNITIPKLVNVICSNPGDQKSKSIMSLDLTT 293
Cdd:TIGR00864    1 DISNNKISTIEEGICANLC--NLSEIDLSGNPFECDCGLARLPRWAEEK-GVKVRQPEAALCAGPGALAGQPLLGIPLLD 77


                   ....
gi 924182698   294 CVSD 297
Cdd:TIGR00864   78 SGCD 81
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
13-272 5.64e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.30  E-value: 5.64e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698  13 RLDFDDNNAFSDLHDLEVLDLSHNAhyfsiagVTHRLGFIQNLINLRVLNLSHNGIYTLTEE-SELKsiSLKELVFSGNR 91
Cdd:COG4886  100 ELDLSGNEELSNLTNLESLDLSGNQ-------LTDLPEELANLTNLKELDLSNNQLTDLPEPlGNLT--NLKSLDLSNNQ 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698  92 LDRLWNAndgkywsiFKSLQNLIRLDLSYNNLQQIPNgAFLNLPqSLQELLISGNKLRFFNWTLLQyFPHLHLLDLSRNE 171
Cdd:COG4886  171 LTDLPEE--------LGNLTNLKELDLSNNQITDLPE-PLGNLT-NLEELDLSGNQLTDLPEPLAN-LTNLETLDLSNNQ 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698 172 LYFLPNcLSKFaHSLETLLLSHNHFSHLPSgfLSEARNLVHLDLSFNTIKMINKSSLQTKMKTNLSILELHGNYFDCTCD 251
Cdd:COG4886  240 LTDLPE-LGNL-TNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315

                        250       260
                 ....*....|....*....|.
gi 924182698 252 ISDFRSWLDENLNITIPKLVN 272
Cdd:COG4886  316 LLLLLTTLLLLLLLLKGLLVT 336
TIR smart00255
Toll - interleukin 1 - resistance;
352-488 3.63e-14

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 69.66  E-value: 3.63e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698   352 YDAYISYdtkdaSVTDWVINELRYHLEESEDKSVLlCLEERDWDPGLPIIDNLMQSINQSKKTIFVLTKKYAKSWNFKTA 431
Cdd:smart00255   2 YDVFISY-----SGKEDVRNEFLSHLLEKLRGYGL-CVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 924182698   432 FYLALQRLMDENMDVIIFILLEPVLQY--SQYLRLRqRICKSSILQWPNNPKAEnlFWQ 488
Cdd:smart00255  76 LVAALENALEEGGLRVIPIFYEVIPSDvrKQPGKFR-KVFKKNYLKWPEDEKEQ--FWK 131
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
7-244 4.42e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 4.42e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698   7 LDLTNNRLDFDDNNAFSDLHDLEVLDLSHNAHYFSIAGVTHRLGFIQNLINLRVLNLSHN-GIYTLTEESEL-------- 77
Cdd:COG4886   47 LLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNeELSNLTNLESLdlsgnqlt 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698  78 -------KSISLKELVFSGNRLDRLWNAndgkywsiFKSLQNLIRLDLSYNNLQQIPNgAFLNLPQsLQELLISGNKLRF 150
Cdd:COG4886  127 dlpeelaNLTNLKELDLSNNQLTDLPEP--------LGNLTNLKSLDLSNNQLTDLPE-ELGNLTN-LKELDLSNNQITD 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698 151 FNWTLLQyFPHLHLLDLSRNELYFLPNCLSKFaHSLETLLLSHNHFSHLPSgfLSEARNLVHLDLSFNTIKMINKSSLqt 230
Cdd:COG4886  197 LPEPLGN-LTNLEELDLSGNQLTDLPEPLANL-TNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLAN-- 270

                        250
                 ....*....|....
gi 924182698 231 kmKTNLSILELHGN 244
Cdd:COG4886  271 --LTNLKTLDLSNN 282
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-245 2.10e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 2.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698   1 MPHIKYLDLTNNRLDfDDNNAFSDLHDLEVLDLSHNahyfSIAGVTHrlgFIQNLINLRVLNLSHNGIYTLTEE-SELKs 79
Cdd:COG4886  135 LTNLKELDLSNNQLT-DLPEPLGNLTNLKSLDLSNN----QLTDLPE---ELGNLTNLKELDLSNNQITDLPEPlGNLT- 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698  80 iSLKELVFSGNRLDRLWNAndgkywsiFKSLQNLIRLDLSYNNLQQIPNgaFLNLPqSLQELLISGNKLRFFnwTLLQYF 159
Cdd:COG4886  206 -NLEELDLSGNQLTDLPEP--------LANLTNLETLDLSNNQLTDLPE--LGNLT-NLEELDLSNNQLTDL--PPLANL 271

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698 160 PHLHLLDLSRNELYFLpnCLSKFAHSLETLLLSHNHFSHLPSGFLSEARNLVHLDLSFNTIKMINKSSLQTKMKTNLSIL 239
Cdd:COG4886  272 TNLKTLDLSNNQLTDL--KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLAL 349


                 ....*.
gi 924182698 240 ELHGNY 245
Cdd:COG4886  350 LTLLLL 355
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-279 4.16e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.95  E-value: 4.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698   1 MPHIKYLDLTNNRLDfDDNNAFSDLHDLEVLDLSHNahyfSIAGVTHRLGfiqNLINLRVLNLSHNGIYTLTEE-SELKs 79
Cdd:COG4886  158 LTNLKSLDLSNNQLT-DLPEELGNLTNLKELDLSNN----QITDLPEPLG---NLTNLEELDLSGNQLTDLPEPlANLT- 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698  80 iSLKELVFSGNRLDRLwnandgkywSIFKSLQNLIRLDLSYNNLQQIPNGAFLnlpQSLQELLISGNKLRFFNwtlLQYF 159
Cdd:COG4886  229 -NLETLDLSNNQLTDL---------PELGNLTNLEELDLSNNQLTDLPPLANL---TNLKTLDLSNNQLTDLK---LKEL 292

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698 160 PHLHLLDLSRNELYFLPNCLSKFAHSLETLLLSHNHFSHLPSGFLSEARNLVHLDLSFNTIKMINKSSLQTKMKTNLSIL 239
Cdd:COG4886  293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLL 372

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 924182698 240 ELHGNYFDCTCDISDFRSWLDENLNITIPKLVNVICSNPG 279
Cdd:COG4886  373 GLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 352-470 4.09e-09

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 55.83  E-value: 4.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698  352 YDAYISYDTKDasVTDWVINELRYHLEEsedKSVLLCLEERDWDPGLPIIDNLMQSINQSKKTIFVLTKKYAKS-WN--- 427
Cdd:pfam01582   1 YDVFLSFRGSD--TREWFVSHLLKELKQ---KGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSgWClde 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 924182698  428 FKTAFYLALQRLMdenmdVIIFILLEPVLQYSQ-----YLRLRQRICK 470
Cdd:pfam01582  76 LVKILECALDLGQ-----KVIPIFYEVDPSDVRkqtgsFGKAFKKHKK 118
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 355-466 7.48e-09

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 53.86  E-value: 7.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698  355 YISYDTKDASVTDWVINELryhleesEDKSVLLCLEERDWDPGLPIIDNLMQSINQSKKTIFVLTKKYAKSWNFKTAFYL 434
Cdd:pfam13676   2 FISYAGEDRAWAEWLADAL-------EAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEA 74

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 924182698  435 ALQRLMDENmdVIIFILLE-----PVLQYSQYLRLRQ 466
Cdd:pfam13676  75 ALADPEGRK--RLIPVRLEcdlelPGLAGLQYIDLRD 109
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
28-244 5.37e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.94  E-value: 5.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698  28 LEVLDLSHNAHYFSIAGVTHRLGFIQNLINLRVLNLSHNGIYTLTEESELKSISLKELVFSGNRLDRLWNANDGKYWSIF 107
Cdd:COG4886   13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698 108 KSLQNLIRLDLSYNN-LQQIPNGAFLNLP--------------QSLQELLISGNKLRFFNwTLLQYFPHLHLLDLSRNEL 172
Cdd:COG4886   93 GDLTNLTELDLSGNEeLSNLTNLESLDLSgnqltdlpeelanlTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQL 171

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 924182698 173 YFLPNCLSKFaHSLETLLLSHNHFSHLPSGfLSEARNLVHLDLSFNTIKMINKS--SLqtkmkTNLSILELHGN 244
Cdd:COG4886  172 TDLPEELGNL-TNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPEPlaNL-----TNLETLDLSNN 238
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 1-244 7.85e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.24  E-value: 7.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698   1 MPHIKYLDLTNNRLDFDDNNAFSDLHDLEVLDLSHNAhyFSiAGVTHRLGfIQNliNLRVLNLSHNGIYTLTEESELKSI 80
Cdd:PLN00113 307 LQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNK--FS-GEIPKNLG-KHN--NLTVLDLSTNNLTGEIPEGLCSSG 380

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698  81 SLKELVFSGNRLD----------------RLW-NANDGKYWSIFKSLQNLIRLDLSYNNLQ--------QIP-------- 127
Cdd:PLN00113 381 NLFKLILFSNSLEgeipkslgacrslrrvRLQdNSFSGELPSEFTKLPLVYFLDISNNNLQgrinsrkwDMPslqmlsla 460

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698 128 -NGAFLNLPQS-----LQELLISGNKLRFFNWTLLQYFPHLHLLDLSRNELY-FLPNCLSKfAHSLETLLLSHNHFS-HL 199
Cdd:PLN00113 461 rNKFFGGLPDSfgskrLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSS-CKKLVSLDLSHNQLSgQI 539

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 924182698 200 PSGFlSEARNLVHLDLSFNTIK---MINKSSLQTKMKTNLSILELHGN 244
Cdd:PLN00113 540 PASF-SEMPVLSQLDLSQNQLSgeiPKNLGNVESLVQVNISHNHLHGS 586
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 27-246 9.25e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 53.90  E-value: 9.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698  27 DLEVLDLSHNAHYFSIAGVTHRLGFIQNLINLRVLNLSHNGIYTLTE---ESELKSISLKELVFSGNRLDrlwnanDGKY 103
Cdd:cd00116   52 SLKELCLSLNETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCgvlESLLRSSSLQELKLNNNGLG------DRGL 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698 104 WSIFKSLQ----NLIRLDLSYNNLQQ---IPNGAFLNLPQSLQELLISGNKLRFFNWTLL----QYFPHLHLLDLSRNEL 172
Cdd:cd00116  126 RLLAKGLKdlppALEKLVLGRNRLEGascEALAKALRANRDLKELNLANNGIGDAGIRALaeglKANCNLEVLDLNNNGL 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698 173 -----YFLPNCLSKFAhSLETLLLSHNHF-----SHLPSGFLSEARNLVHLDLSFNTIKMINKSSLQTKMKTNLSI--LE 240
Cdd:cd00116  206 tdegaSALAETLASLK-SLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLleLD 284


                 ....*.
gi 924182698 241 LHGNYF 246
Cdd:cd00116  285 LRGNKF 290
LRR_8 pfam13855
Leucine rich repeat;
81-148 2.22e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 2.22e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 924182698   81 SLKELVFSGNRLDRLwnandgkYWSIFKSLQNLIRLDLSYNNLQQIPNGAFLNLPqSLQELLISGNKL 148
Cdd:pfam13855   2 NLRSLDLSNNRLTSL-------DDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP-SLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
111-172 3.81e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 3.81e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 924182698  111 QNLIRLDLSYNNLQQIPNGAFLNLPqSLQELLISGNKLRFFNWTLLQYFPHLHLLDLSRNEL 172
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLS-NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 52-244 1.05e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 1.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698  52 IQNLI---NLRVLNLSHNGIYTLTEESELKSisLKELVFSGNRLDRLWNandgkywsiFKSLQNLIRLDLSYNNLQQIPN 128
Cdd:cd21340   17 IDNLSlckNLKVLYLYDNKITKIENLEFLTN--LTHLYLQNNQIEKIEN---------LENLVNLKKLYLGGNRISVVEG 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698 129 gafLNLPQSLQELLISGNKLRffnwtllqyfphlhlldlSRNELYFLPNCLSKFAHSLETLLLSHNHFSHLpsGFLSEAR 208
Cdd:cd21340   86 ---LENLTNLEELHIENQRLP------------------PGEKLTFDPRSLAALSNSLRVLNISGNNIDSL--EPLAPLR 142

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 924182698 209 NLVHLDLSFNTIKMINKSSLQTKMKTNLSILELHGN 244
Cdd:cd21340  143 NLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 1-201 2.26e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.62  E-value: 2.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698   1 MPHIKYLDLTNNRLDFDDNNAFSDLHDLEVLDLSHNAHYfsiAGVTHRLGfiqnLINLRVLNLSHNGIYTLTEESELKSI 80
Cdd:PLN00113 427 LPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFF---GGLPDSFG----SKRLENLDLSRNQFSGAVPRKLGSLS 499

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698  81 SLKELVFSGNRLdrlwnanDGKYWSIFKSLQNLIRLDLSYNNLqqipNGaflNLPQSLQEllisgnklrffnwtllqyFP 160
Cdd:PLN00113 500 ELMQLKLSENKL-------SGEIPDELSSCKKLVSLDLSHNQL----SG---QIPASFSE------------------MP 547

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 924182698 161 HLHLLDLSRNELYF-LPNCLSKfAHSLETLLLSHNHF-SHLPS 201
Cdd:PLN00113 548 VLSQLDLSQNQLSGeIPKNLGN-VESLVQVNISHNHLhGSLPS 589
LRR_8 pfam13855
Leucine rich repeat;
2-68 3.71e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 3.71e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 924182698    2 PHIKYLDLTNNRLDFDDNNAFSDLHDLEVLDLSHNahyfSIAGVthRLGFIQNLINLRVLNLSHNGI 68
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN----LLTTL--SPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
111-248 8.36e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.54  E-value: 8.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698 111 QNLIRLDLSYNNLQQIPNgaflNLPQSLQELLISGNKLRFFNWTLlqyfPH-LHLLDLSRNELYFLPNCLSKfahSLETL 189
Cdd:PRK15370 199 EQITTLILDNNELKSLPE----NLQGNIKTLYANSNQLTSIPATL----PDtIQEMELSINRITELPERLPS---ALQSL 267

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 924182698 190 LLSHNHFSHLPSGFLSEARNL-----------VHLDLSFNTIKMINKS--SLQTKMKTNLSILELHGNYFDC 248
Cdd:PRK15370 268 DLFHNKISCLPENLPEELRYLsvydnsirtlpAHLPSGITHLNVQSNSltALPETLPPGLKTLEAGENALTS 339
LRR_8 pfam13855
Leucine rich repeat;
1-36 5.00e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 5.00e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 924182698    1 MPHIKYLDLTNNRLDFDDNNAFSDLHDLEVLDLSHN 36
Cdd:pfam13855  24 LSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 55-242 1.34e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.40  E-value: 1.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698  55 LINLRVLNLSHNGIYTLTEESElKSISLKELVFSGNRLDrlwnaNDGKYwSIFKSLQNLIR---LDLSYNnlqQIPNGAF 131
Cdd:COG5238  184 TVYLGCNQIGDEGIEELAEALT-QNTTVTTLWLKRNPIG-----DEGAE-ILAEALKGNKSlttLDLSNN---QIGDEGV 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698 132 LNLPQSLQE------LLISGNKL-----RFFNwTLLQYFPHLHLLDLSRNELYF-----LPNCLSKfAHSLETLLLSHNH 195
Cdd:COG5238  254 IALAEALKNnttvetLYLSGNQIgaegaIALA-KALQGNTTLTSLDLSVNRIGDegaiaLAEGLQG-NKTLHTLNLAYNG 331

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 924182698 196 FSHLPSGFLSEA----RNLVHLDLSFNTIKMINKSSLQTKMKTNLSILELH 242
Cdd:COG5238  332 IGAQGAIALAKAlqenTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELN 382
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 1-146 1.45e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 1.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698   1 MPHIKYLDLTNNRLDFDDNnaFSDLHDLEVLDLSHNahyfSIAgvthRLGFIQNLINLRVLNLSHNgiyTLTEESEL--- 77
Cdd:cd21340   45 LTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGN----RIS----VVEGLENLTNLEELHIENQ---RLPPGEKLtfd 111

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 924182698  78 ----KSI--SLKELVFSGNRLDRLwnandgkywSIFKSLQNLIRLDLSYNNLQQIPN--GAFLNLPQsLQELLISGN 146
Cdd:cd21340  112 prslAALsnSLRVLNISGNNIDSL---------EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPS-LRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 1-220 5.06e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.91  E-value: 5.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698   1 MPHIKYLDLTNNRLDFDDNNAFSDLHDLEVLDLSHNAHyfsiagVTHRLGFIQNLINLRVLNLSHNGI-----YTLTEES 75
Cdd:PLN00113 139 IPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVL------VGKIPNSLTNLTSLEFLTLASNQLvgqipRELGQMK 212

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698  76 ELKSISLKELVFSG------------NRLDRLWNANDGKYWSIFKSLQNLIRLDLSYNNLQ-QIPNGAFlNLpQSLQELL 142
Cdd:PLN00113 213 SLKWIYLGYNNLSGeipyeiggltslNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-SL-QKLISLD 290

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 924182698 143 ISGNKLRFFNWTLLQYFPHLHLLDLSRNELY-FLPNCLSKFAHsLETLLLSHNHFSHLPSGFLSEARNLVHLDLSFNTI 220
Cdd:PLN00113 291 LSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPR-LQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNL 368
LRR_8 pfam13855
Leucine rich repeat;
160-218 9.65e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 9.65e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 924182698  160 PHLHLLDLSRNELYFLPNCLSKFAHSLETLLLSHNHFSHLPSGFLSEARNLVHLDLSFN 218
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 214-297 2.30e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 40.84  E-value: 2.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698   214 DLSFNTIKMINKSSLQTKMktNLSILELHGNYFDCTCDISDFRSWLDENlNITIPKLVNVICSNPGDQKSKSIMSLDLTT 293
Cdd:TIGR00864    1 DISNNKISTIEEGICANLC--NLSEIDLSGNPFECDCGLARLPRWAEEK-GVKVRQPEAALCAGPGALAGQPLLGIPLLD 77


                   ....
gi 924182698   294 CVSD 297
Cdd:TIGR00864   78 SGCD 81
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 2-148 2.98e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 2.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698   2 PHIKYLDLTNNRLD----FDDNNAFSDLHDLEVLDLSHNAhyFSIAGVTHRLGFIQNLINLRVLNLSHNGIytlTEE--- 74
Cdd:cd00116  137 PALEKLVLGRNRLEgascEALAKALRANRDLKELNLANNG--IGDAGIRALAEGLKANCNLEVLDLNNNGL---TDEgas 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698  75 --SE-LKS-ISLKELVFSGNRLDrlwNANDGKYWSIFKSL-QNLIRLDLSYNNLQQIPNGAFLN-LPQ--SLQELLISGN 146
Cdd:cd00116  212 alAEtLASlKSLEVLNLGDNNLT---DAGAAALASALLSPnISLLTLSLSCNDITDDGAKDLAEvLAEkeSLLELDLRGN 288


                 ..
gi 924182698 147 KL 148
Cdd:cd00116  289 KF 290
LRR_8 pfam13855
Leucine rich repeat;
185-246 4.03e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 4.03e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 924182698  185 SLETLLLSHNHFSHLPSGFLSEARNLVHLDLSFNTIKMINKSSLQtKMKtNLSILELHGNYF 246
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFS-GLP-SLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 105-220 7.99e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 38.49  E-value: 7.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924182698 105 SIFKSLQNLIRLDLSYNNLQQIPNGAF---LNLPQSLQELLISGNKLRFF--NW-TLLQYFPH---LHLLDLSRNEL--- 172
Cdd:cd00116   17 ELLPKLLCLQVLRLEGNTLGEEAAKALasaLRPQPSLKELCLSLNETGRIprGLqSLLQGLTKgcgLQELDLSDNALgpd 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 924182698 173 --YFLPNCLSKFahSLETLLLSHN-----HFSHLPSGFLSEARNLVHLDLSFNTI 220
Cdd:cd00116   97 gcGVLESLLRSS--SLQELKLNNNglgdrGLRLLAKGLKDLPPALEKLVLGRNRL 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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