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Conserved domains on  [gi|928192549|ref|NP_001300901|]
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thioredoxin-interacting protein isoform 2 [Homo sapiens]

Protein Classification

arrestin family protein( domain architecture ID 10432288)

arrestin family protein with both N-terminal and C-terminal Ig-like beta-sandwich domains found in arrestin (S antigen); similar to Homo sapiens thioredoxin-interacting protein and arrestin domain-containing protein

CATH:  2.60.40.840
Gene Ontology:  GO:0005515
PubMed:  7720881
SCOP:  4007521

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arrestin_C pfam02752
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 119-243 8.98e-21

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain.


:

Pssm-ID: 460676  Cd Length: 135  Bit Score: 86.61  E-value: 8.98e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928192549  119 PDGRVSVSARIDRKGFCEGDEISIHADFENTCSRIVVP-KAAIVARHTYLAN---GQTKVLTQKLSSVRGNHIISGTCAS 194
Cdd:pfam02752   1 WSGKVSYSVSLPKKGYVPGETIPVTIEIDNQSKKKIKKiKISLVQQLTYKAKtplGESKREERVVAKEKNPGVAPGSKDK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 928192549  195 WR-GKSLRV-QKIRPSILGCNILRVEYSLLIYVSVPGS-KKVILDLPLVIGS 243
Cdd:pfam02752  81 WEkELQLQIpTDLPPSSTKCKIIKVEYKLKVTVDLSGSaSELRLELPITIGT 132
Arrestin_N super family cl22903
Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 12-97 9.64e-12

Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.


The actual alignment was detected with superfamily member pfam00339:

Pssm-ID: 451447  Cd Length: 148  Bit Score: 61.92  E-value: 9.64e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928192549   12 ILSVTASLMAtrfSFPSGENEMvimrPGNKYEYKFGFELPQGPLgTSFKGKYGCVDYWVKAFLDRPSQPTQETKKNFEVV 91
Cdd:pfam00339  71 YLPTETSLWG---SKTGGQNKL----PAGTHTFPFSFTLPPNCP-SSFEGKHGGIRYEVKVTLDRPWKFNKSFRRVFTVI 142


                  ....*.
gi 928192549   92 DLVDVN 97
Cdd:pfam00339 143 PKLDLN 148
 
Name Accession Description Interval E-value
Arrestin_C pfam02752
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 119-243 8.98e-21

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain.


Pssm-ID: 460676  Cd Length: 135  Bit Score: 86.61  E-value: 8.98e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928192549  119 PDGRVSVSARIDRKGFCEGDEISIHADFENTCSRIVVP-KAAIVARHTYLAN---GQTKVLTQKLSSVRGNHIISGTCAS 194
Cdd:pfam02752   1 WSGKVSYSVSLPKKGYVPGETIPVTIEIDNQSKKKIKKiKISLVQQLTYKAKtplGESKREERVVAKEKNPGVAPGSKDK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 928192549  195 WR-GKSLRV-QKIRPSILGCNILRVEYSLLIYVSVPGS-KKVILDLPLVIGS 243
Cdd:pfam02752  81 WEkELQLQIpTDLPPSSTKCKIIKVEYKLKVTVDLSGSaSELRLELPITIGT 132
Arrestin_C smart01017
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 120-243 2.59e-20

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X). which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction.


Pssm-ID: 214976 [Multi-domain]  Cd Length: 142  Bit Score: 85.47  E-value: 2.59e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928192549   120 DGRVSVSARIDRKGFCEGDEISIHADFENTCSRIVV-PKAAIVARHTYLAN------------GQTKVLTQKLSSVR-GN 185
Cdd:smart01017   2 SGPLSLEVSLPKKGYVPGETIPVTIKITNLSKKTVKkIKVSLVQTVTYVSSdgpvkrslaeksKEKKADRKTLVKELdGG 81

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 928192549   186 HIISGTCASWrGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPG-SKKVILDLPLVIGS 243
Cdd:smart01017  82 PVLPGNKDKF-EGQLKVPPLPPTSRTCRLIKVEYKLKVKLRLSGkHSELRLELPITIGT 139
Arrestin_N pfam00339
Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 12-97 9.64e-12

Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.


Pssm-ID: 425619  Cd Length: 148  Bit Score: 61.92  E-value: 9.64e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928192549   12 ILSVTASLMAtrfSFPSGENEMvimrPGNKYEYKFGFELPQGPLgTSFKGKYGCVDYWVKAFLDRPSQPTQETKKNFEVV 91
Cdd:pfam00339  71 YLPTETSLWG---SKTGGQNKL----PAGTHTFPFSFTLPPNCP-SSFEGKHGGIRYEVKVTLDRPWKFNKSFRRVFTVI 142


                  ....*.
gi 928192549   92 DLVDVN 97
Cdd:pfam00339 143 PKLDLN 148
 
Name Accession Description Interval E-value
Arrestin_C pfam02752
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 119-243 8.98e-21

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain.


Pssm-ID: 460676  Cd Length: 135  Bit Score: 86.61  E-value: 8.98e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928192549  119 PDGRVSVSARIDRKGFCEGDEISIHADFENTCSRIVVP-KAAIVARHTYLAN---GQTKVLTQKLSSVRGNHIISGTCAS 194
Cdd:pfam02752   1 WSGKVSYSVSLPKKGYVPGETIPVTIEIDNQSKKKIKKiKISLVQQLTYKAKtplGESKREERVVAKEKNPGVAPGSKDK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 928192549  195 WR-GKSLRV-QKIRPSILGCNILRVEYSLLIYVSVPGS-KKVILDLPLVIGS 243
Cdd:pfam02752  81 WEkELQLQIpTDLPPSSTKCKIIKVEYKLKVTVDLSGSaSELRLELPITIGT 132
Arrestin_C smart01017
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 120-243 2.59e-20

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X). which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction.


Pssm-ID: 214976 [Multi-domain]  Cd Length: 142  Bit Score: 85.47  E-value: 2.59e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928192549   120 DGRVSVSARIDRKGFCEGDEISIHADFENTCSRIVV-PKAAIVARHTYLAN------------GQTKVLTQKLSSVR-GN 185
Cdd:smart01017   2 SGPLSLEVSLPKKGYVPGETIPVTIKITNLSKKTVKkIKVSLVQTVTYVSSdgpvkrslaeksKEKKADRKTLVKELdGG 81

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 928192549   186 HIISGTCASWrGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPG-SKKVILDLPLVIGS 243
Cdd:smart01017  82 PVLPGNKDKF-EGQLKVPPLPPTSRTCRLIKVEYKLKVKLRLSGkHSELRLELPITIGT 139
Arrestin_N pfam00339
Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 12-97 9.64e-12

Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.


Pssm-ID: 425619  Cd Length: 148  Bit Score: 61.92  E-value: 9.64e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928192549   12 ILSVTASLMAtrfSFPSGENEMvimrPGNKYEYKFGFELPQGPLgTSFKGKYGCVDYWVKAFLDRPSQPTQETKKNFEVV 91
Cdd:pfam00339  71 YLPTETSLWG---SKTGGQNKL----PAGTHTFPFSFTLPPNCP-SSFEGKHGGIRYEVKVTLDRPWKFNKSFRRVFTVI 142


                  ....*.
gi 928192549   92 DLVDVN 97
Cdd:pfam00339 143 PKLDLN 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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