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Conserved domains on  [gi|930155608|ref|NP_001300951|]
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endoribonuclease YbeY isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK13963 super family cl46897
rRNA maturation RNase YbeY;
35-106 8.68e-30

rRNA maturation RNase YbeY;


The actual alignment was detected with superfamily member TIGR00043:

Pssm-ID: 481237 [Multi-domain]  Cd Length: 110  Bit Score: 103.11  E-value: 8.68e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930155608   35 FDLGIICVDNKNIQHINRIYRDRNVPTDVLSFPFHE--------------------------------------VTATHG 76
Cdd:TIGR00043   1 GELSLLFVDDEEIQELNREYRDKDYPTDVLSFPYEEeeppggfpeevlgdivislevakeqakeyghslerelaHLTVHG 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 930155608   77 LCHLLGFTHGTEAEWQQMFQKEKAVLDELG 106
Cdd:TIGR00043  81 LLHLLGYDHETEDEEKEMFALEEEILALLG 110
 
Name Accession Description Interval E-value
TIGR00043 TIGR00043
rRNA maturation RNase YbeY; This metalloprotein family is represented by a single member ...
 35-106 8.68e-30

rRNA maturation RNase YbeY; This metalloprotein family is represented by a single member sequence only in nearly every bacterium. Crystallography demonstrated metal-binding activity, possibly to nickel. It is a predicted to be a metallohydrolase, and more recently it was shown that mutants have a ribosomal RNA processing defect. [Protein synthesis, Other]


Pssm-ID: 272871 [Multi-domain]  Cd Length: 110  Bit Score: 103.11  E-value: 8.68e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930155608   35 FDLGIICVDNKNIQHINRIYRDRNVPTDVLSFPFHE--------------------------------------VTATHG 76
Cdd:TIGR00043   1 GELSLLFVDDEEIQELNREYRDKDYPTDVLSFPYEEeeppggfpeevlgdivislevakeqakeyghslerelaHLTVHG 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 930155608   77 LCHLLGFTHGTEAEWQQMFQKEKAVLDELG 106
Cdd:TIGR00043  81 LLHLLGYDHETEDEEKEMFALEEEILALLG 110
YbeY COG0319
ssRNA-specific RNase YbeY, 16S rRNA maturation enzyme [Translation, ribosomal structure and ...
 1-106 5.54e-24

ssRNA-specific RNase YbeY, 16S rRNA maturation enzyme [Translation, ribosomal structure and biogenesis]; ssRNA-specific RNase YbeY, 16S rRNA maturation enzyme is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440088  Cd Length: 144  Bit Score: 89.45  E-value: 5.54e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930155608   1 MSLVIRNLQRViPIRRAPLRSKIEIVRRILGVQK-FDLGIICVDNKNIQHINRIYRDRNVPTDVLSFPFHEVT------- 72
Cdd:COG0319    1 MSIEIQNEDDF-ELDEALLERWLEAALEAEGLAEdAELSVRFVDDEEIRELNREYRGKDKPTDVLSFPYDELPedgppll 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 930155608  73 ----------------------------ATHGLCHLLGFTHGTEAEWQQMFQKEKAVLDELG 106
Cdd:COG0319   80 gdivisvetaareakeqghsfedelahlLVHGLLHLLGYDHETEEEAEEMEALEEEILAKLG 141
YbeY pfam02130
Endoribonuclease YbeY; YbeY is a single strand-specific metallo-endoribonuclease involved in ...
 24-105 1.06e-22

Endoribonuclease YbeY; YbeY is a single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. It acts together with the RNase R to eliminate defective 70S ribosomes, but not properly maturated 70S ribosomes or individual subunits, by a process mediated specifically by the 30S ribosomal subunit. It is involved in the processing of 16S, 23S and 5S rRNAs, with a particularly strong effect on maturation at both the 5'-and 3'-ends of 16S rRNA as well as maturation of the 5'-end of 23S and 5S rRNAs. The crystal structure of the protein from Aquifex aeolicus showed an overall fold consisting of one central alpha-helix surrounded by a four-stranded beta-sheet and four other alpha-helices.


Pssm-ID: 460455  Cd Length: 125  Bit Score: 85.60  E-value: 1.06e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930155608   24 EIVRRILGVQKFD----LGIICVDNKNIQHINRIYRDRNVPTDVLSFPFHEVT--------------------------- 72
Cdd:pfam02130   9 LVLEAALDEEKVPyeaeVSVTFVDNEEIRELNKEYRGKDKPTDVLSFPMDEPEeplgdivispekakeqaeeyghslere 88

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 930155608   73 ----ATHGLCHLLGFTHGTEAEWQQMFQKEKAVLDEL 105
Cdd:pfam02130  89 laflTVHGLLHLLGYDHEEEEEAKEMEELEEEILNKL 125
 
Name Accession Description Interval E-value
TIGR00043 TIGR00043
rRNA maturation RNase YbeY; This metalloprotein family is represented by a single member ...
 35-106 8.68e-30

rRNA maturation RNase YbeY; This metalloprotein family is represented by a single member sequence only in nearly every bacterium. Crystallography demonstrated metal-binding activity, possibly to nickel. It is a predicted to be a metallohydrolase, and more recently it was shown that mutants have a ribosomal RNA processing defect. [Protein synthesis, Other]


Pssm-ID: 272871 [Multi-domain]  Cd Length: 110  Bit Score: 103.11  E-value: 8.68e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930155608   35 FDLGIICVDNKNIQHINRIYRDRNVPTDVLSFPFHE--------------------------------------VTATHG 76
Cdd:TIGR00043   1 GELSLLFVDDEEIQELNREYRDKDYPTDVLSFPYEEeeppggfpeevlgdivislevakeqakeyghslerelaHLTVHG 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 930155608   77 LCHLLGFTHGTEAEWQQMFQKEKAVLDELG 106
Cdd:TIGR00043  81 LLHLLGYDHETEDEEKEMFALEEEILALLG 110
YbeY COG0319
ssRNA-specific RNase YbeY, 16S rRNA maturation enzyme [Translation, ribosomal structure and ...
 1-106 5.54e-24

ssRNA-specific RNase YbeY, 16S rRNA maturation enzyme [Translation, ribosomal structure and biogenesis]; ssRNA-specific RNase YbeY, 16S rRNA maturation enzyme is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440088  Cd Length: 144  Bit Score: 89.45  E-value: 5.54e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930155608   1 MSLVIRNLQRViPIRRAPLRSKIEIVRRILGVQK-FDLGIICVDNKNIQHINRIYRDRNVPTDVLSFPFHEVT------- 72
Cdd:COG0319    1 MSIEIQNEDDF-ELDEALLERWLEAALEAEGLAEdAELSVRFVDDEEIRELNREYRGKDKPTDVLSFPYDELPedgppll 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 930155608  73 ----------------------------ATHGLCHLLGFTHGTEAEWQQMFQKEKAVLDELG 106
Cdd:COG0319   80 gdivisvetaareakeqghsfedelahlLVHGLLHLLGYDHETEEEAEEMEALEEEILAKLG 141
YbeY pfam02130
Endoribonuclease YbeY; YbeY is a single strand-specific metallo-endoribonuclease involved in ...
 24-105 1.06e-22

Endoribonuclease YbeY; YbeY is a single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. It acts together with the RNase R to eliminate defective 70S ribosomes, but not properly maturated 70S ribosomes or individual subunits, by a process mediated specifically by the 30S ribosomal subunit. It is involved in the processing of 16S, 23S and 5S rRNAs, with a particularly strong effect on maturation at both the 5'-and 3'-ends of 16S rRNA as well as maturation of the 5'-end of 23S and 5S rRNAs. The crystal structure of the protein from Aquifex aeolicus showed an overall fold consisting of one central alpha-helix surrounded by a four-stranded beta-sheet and four other alpha-helices.


Pssm-ID: 460455  Cd Length: 125  Bit Score: 85.60  E-value: 1.06e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930155608   24 EIVRRILGVQKFD----LGIICVDNKNIQHINRIYRDRNVPTDVLSFPFHEVT--------------------------- 72
Cdd:pfam02130   9 LVLEAALDEEKVPyeaeVSVTFVDNEEIRELNKEYRGKDKPTDVLSFPMDEPEeplgdivispekakeqaeeyghslere 88

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 930155608   73 ----ATHGLCHLLGFTHGTEAEWQQMFQKEKAVLDEL 105
Cdd:pfam02130  89 laflTVHGLLHLLGYDHEEEEEAKEMEELEEEILNKL 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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