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Conserved domains on  [gi|930155612|ref|NP_001300953|]
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endoribonuclease YbeY isoform 5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK13963 super family cl46897
rRNA maturation RNase YbeY;
27-61 3.33e-13

rRNA maturation RNase YbeY;


The actual alignment was detected with superfamily member TIGR00043:

Pssm-ID: 481237 [Multi-domain]  Cd Length: 110  Bit Score: 59.20  E-value: 3.33e-13
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 930155612   27 TATHGLCHLLGFTHGTEAEWQQMFQKEKAVLDELG 61
Cdd:TIGR00043  76 LTVHGLLHLLGYDHETEDEEKEMFALEEEILALLG 110
 
Name Accession Description Interval E-value
TIGR00043 TIGR00043
rRNA maturation RNase YbeY; This metalloprotein family is represented by a single member ...
 27-61 3.33e-13

rRNA maturation RNase YbeY; This metalloprotein family is represented by a single member sequence only in nearly every bacterium. Crystallography demonstrated metal-binding activity, possibly to nickel. It is a predicted to be a metallohydrolase, and more recently it was shown that mutants have a ribosomal RNA processing defect. [Protein synthesis, Other]


Pssm-ID: 272871 [Multi-domain]  Cd Length: 110  Bit Score: 59.20  E-value: 3.33e-13
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 930155612   27 TATHGLCHLLGFTHGTEAEWQQMFQKEKAVLDELG 61
Cdd:TIGR00043  76 LTVHGLLHLLGYDHETEDEEKEMFALEEEILALLG 110
YbeY pfam02130
Endoribonuclease YbeY; YbeY is a single strand-specific metallo-endoribonuclease involved in ...
 28-60 6.10e-10

Endoribonuclease YbeY; YbeY is a single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. It acts together with the RNase R to eliminate defective 70S ribosomes, but not properly maturated 70S ribosomes or individual subunits, by a process mediated specifically by the 30S ribosomal subunit. It is involved in the processing of 16S, 23S and 5S rRNAs, with a particularly strong effect on maturation at both the 5'-and 3'-ends of 16S rRNA as well as maturation of the 5'-end of 23S and 5S rRNAs. The crystal structure of the protein from Aquifex aeolicus showed an overall fold consisting of one central alpha-helix surrounded by a four-stranded beta-sheet and four other alpha-helices.


Pssm-ID: 460455  Cd Length: 125  Bit Score: 51.32  E-value: 6.10e-10
                          10        20        30
                  ....*....|....*....|....*....|...
gi 930155612   28 ATHGLCHLLGFTHGTEAEWQQMFQKEKAVLDEL 60
Cdd:pfam02130  93 TVHGLLHLLGYDHEEEEEAKEMEELEEEILNKL 125
YbeY COG0319
ssRNA-specific RNase YbeY, 16S rRNA maturation enzyme [Translation, ribosomal structure and ...
 28-61 6.11e-10

ssRNA-specific RNase YbeY, 16S rRNA maturation enzyme [Translation, ribosomal structure and biogenesis]; ssRNA-specific RNase YbeY, 16S rRNA maturation enzyme is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440088  Cd Length: 144  Bit Score: 51.70  E-value: 6.11e-10
                         10        20        30
                 ....*....|....*....|....*....|....
gi 930155612  28 ATHGLCHLLGFTHGTEAEWQQMFQKEKAVLDELG 61
Cdd:COG0319  108 LVHGLLHLLGYDHETEEEAEEMEALEEEILAKLG 141
PLN02887 PLN02887
hydrolase family protein
 26-57 6.20e-03

hydrolase family protein


Pssm-ID: 215479 [Multi-domain]  Cd Length: 580  Bit Score: 33.69  E-value: 6.20e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 930155612  26 VTATHGLCHLLGFTHGTEAEWQQMFQKEKAVL 57
Cdd:PLN02887 232 ILVVHGLLHLLGFDHEISNEAEAEMEKEEELL 263
 
Name Accession Description Interval E-value
TIGR00043 TIGR00043
rRNA maturation RNase YbeY; This metalloprotein family is represented by a single member ...
 27-61 3.33e-13

rRNA maturation RNase YbeY; This metalloprotein family is represented by a single member sequence only in nearly every bacterium. Crystallography demonstrated metal-binding activity, possibly to nickel. It is a predicted to be a metallohydrolase, and more recently it was shown that mutants have a ribosomal RNA processing defect. [Protein synthesis, Other]


Pssm-ID: 272871 [Multi-domain]  Cd Length: 110  Bit Score: 59.20  E-value: 3.33e-13
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 930155612   27 TATHGLCHLLGFTHGTEAEWQQMFQKEKAVLDELG 61
Cdd:TIGR00043  76 LTVHGLLHLLGYDHETEDEEKEMFALEEEILALLG 110
YbeY pfam02130
Endoribonuclease YbeY; YbeY is a single strand-specific metallo-endoribonuclease involved in ...
 28-60 6.10e-10

Endoribonuclease YbeY; YbeY is a single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. It acts together with the RNase R to eliminate defective 70S ribosomes, but not properly maturated 70S ribosomes or individual subunits, by a process mediated specifically by the 30S ribosomal subunit. It is involved in the processing of 16S, 23S and 5S rRNAs, with a particularly strong effect on maturation at both the 5'-and 3'-ends of 16S rRNA as well as maturation of the 5'-end of 23S and 5S rRNAs. The crystal structure of the protein from Aquifex aeolicus showed an overall fold consisting of one central alpha-helix surrounded by a four-stranded beta-sheet and four other alpha-helices.


Pssm-ID: 460455  Cd Length: 125  Bit Score: 51.32  E-value: 6.10e-10
                          10        20        30
                  ....*....|....*....|....*....|...
gi 930155612   28 ATHGLCHLLGFTHGTEAEWQQMFQKEKAVLDEL 60
Cdd:pfam02130  93 TVHGLLHLLGYDHEEEEEAKEMEELEEEILNKL 125
YbeY COG0319
ssRNA-specific RNase YbeY, 16S rRNA maturation enzyme [Translation, ribosomal structure and ...
 28-61 6.11e-10

ssRNA-specific RNase YbeY, 16S rRNA maturation enzyme [Translation, ribosomal structure and biogenesis]; ssRNA-specific RNase YbeY, 16S rRNA maturation enzyme is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440088  Cd Length: 144  Bit Score: 51.70  E-value: 6.11e-10
                         10        20        30
                 ....*....|....*....|....*....|....
gi 930155612  28 ATHGLCHLLGFTHGTEAEWQQMFQKEKAVLDELG 61
Cdd:COG0319  108 LVHGLLHLLGYDHETEEEAEEMEALEEEILAKLG 141
PLN02887 PLN02887
hydrolase family protein
 26-57 6.20e-03

hydrolase family protein


Pssm-ID: 215479 [Multi-domain]  Cd Length: 580  Bit Score: 33.69  E-value: 6.20e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 930155612  26 VTATHGLCHLLGFTHGTEAEWQQMFQKEKAVL 57
Cdd:PLN02887 232 ILVVHGLLHLLGFDHEISNEAEAEMEKEEELL 263
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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