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Conserved domains on  [gi|937500801|ref|NP_001302430|]
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solute carrier family 22 member 18 isoform a [Homo sapiens]

Protein Classification

solute carrier family 22 member 18( domain architecture ID 13023744)

solute carrier family 22 member 18 is a major facilitator superfamily (MFS) transporter that may function as an organic cation/proton antiporter

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 110-498 3.27e-133

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 391.20  E-value: 3.27e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 110 VILLTYVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYL 189
Cdd:cd17331    1 VLLIVHLNIVLYATCYWLQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 190 LLAAAsspalPGVYLLFASRLPGALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCPA 269
Cdd:cd17331   81 LLAFA-----SSVPMLFLSRLPSVFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAA 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 270 ILAALATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPraSVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSII 349
Cdd:cd17331  156 LVAAVGSLLSIVLVILLIPSNTKSKREKEAKESASPP--SVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLV 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 350 SMDFFQLEAAQAGYLMSFFGLLQMVTQGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVFSLCT 429
Cdd:cd17331  234 AMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSV 313

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 937500801 430 LNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFGHVQVAINTLVLLVLWR 498
Cdd:cd17331  314 LYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
 
Name Accession Description Interval E-value
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 110-498 3.27e-133

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 391.20  E-value: 3.27e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 110 VILLTYVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYL 189
Cdd:cd17331    1 VLLIVHLNIVLYATCYWLQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 190 LLAAAsspalPGVYLLFASRLPGALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCPA 269
Cdd:cd17331   81 LLAFA-----SSVPMLFLSRLPSVFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAA 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 270 ILAALATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPraSVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSII 349
Cdd:cd17331  156 LVAAVGSLLSIVLVILLIPSNTKSKREKEAKESASPP--SVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLV 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 350 SMDFFQLEAAQAGYLMSFFGLLQMVTQGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVFSLCT 429
Cdd:cd17331  234 AMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSV 313

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 937500801 430 LNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFGHVQVAINTLVLLVLWR 498
Cdd:cd17331  314 LYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
103-458 1.34e-20

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 93.11  E-value: 1.34e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 103 SALGRSSVILLTYVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFL 182
Cdd:COG2814    4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 183 AALALYLLLaaassPALPGVYLLFASRLPGALMHTL--PAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLV 260
Cdd:COG2814   84 LFALGSLLC-----ALAPSLWLLLAARFLQGLGAGAlfPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 261 SAYGIQCPAILAALATLLGAVLSFTCIPASTKGAKTDAQAplpggprasvfdlkAIASLLRLPDVPRIFLVKVASNCPTG 340
Cdd:COG2814  159 DLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRG--------------SLRELLRRPRLLLLLLLAFLLGFGFF 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 341 LFMVMFSIISMDFFQLEAAQAGYLMSFFGLLQMVTQgLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLV 420
Cdd:COG2814  225 ALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGA-LLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLAL 303

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 937500801 421 PGLVFSLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQ 458
Cdd:COG2814  304 FLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAF 341
MFS_1 pfam07690
Major Facilitator Superfamily;
111-466 1.76e-14

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 74.76  E-value: 1.76e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801  111 ILLTYVLAATELTCLFmqFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLL 190
Cdd:pfam07690   1 LFLAAFLAALGRSLLG--PALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801  191 LAAAsspalPGVYLLFASRLPGALMH--TLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQcp 268
Cdd:pfam07690  79 LLFA-----SSLWLLLVLRVLQGLGAgaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWR-- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801  269 ailaaLATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPRASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSI 348
Cdd:pfam07690 152 -----AAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801  349 isMDFFQLEAAQAGYLMSFFGLLqMVTQGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLV---F 425
Cdd:pfam07690 227 --QEVLGLSALLAGLLLGLGGLL-GAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLllgF 303

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 937500801  426 SLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGP 466
Cdd:pfam07690 304 GFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
 
Name Accession Description Interval E-value
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 110-498 3.27e-133

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 391.20  E-value: 3.27e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 110 VILLTYVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYL 189
Cdd:cd17331    1 VLLIVHLNIVLYATCYWLQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 190 LLAAAsspalPGVYLLFASRLPGALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCPA 269
Cdd:cd17331   81 LLAFA-----SSVPMLFLSRLPSVFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAA 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 270 ILAALATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPraSVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSII 349
Cdd:cd17331  156 LVAAVGSLLSIVLVILLIPSNTKSKREKEAKESASPP--SVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLV 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 350 SMDFFQLEAAQAGYLMSFFGLLQMVTQGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVFSLCT 429
Cdd:cd17331  234 AMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSV 313

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 937500801 430 LNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFGHVQVAINTLVLLVLWR 498
Cdd:cd17331  314 LYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 115-498 3.61e-55

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 188.56  E-value: 3.61e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 115 YVLAATELTCLFMQFSIVPYLSR---KLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLL 191
Cdd:cd17330    2 FLVVFLDALGFGIVFPVLPFYVRefnKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 192 AAasspALPGVYLLFASRLPGALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCPAIL 271
Cdd:cd17330   82 GL----SRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLV 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 272 AalatllgavlsftcipastkgaktdaqaplpggprASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISM 351
Cdd:cd17330  158 A-----------------------------------AALALLNLVLVLFFLPPLRRLLLVYFLIALAFAGLESVFSLFLK 202

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 352 DFFQLEAAQAGYLMSFFGLLQMVTQGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVFSLCTLN 431
Cdd:cd17330  203 DRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVF 282

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 937500801 432 VVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFGHVQVAINTLVLLVLWR 498
Cdd:cd17330  283 PALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 115-500 5.93e-30

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 120.02  E-value: 5.93e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 115 YVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLLAAA 194
Cdd:cd17390    2 YLVGFLDLFGVSMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 195 SSpalpgVYLLFASRLP-GALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLV-SAYGIQCPaila 272
Cdd:cd17390   82 TS-----LALLFLSRIPlGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAeTDGGFYYV---- 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 273 alatllgavlSFTCipastkgaktdaqaplpggprASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMD 352
Cdd:cd17390  153 ----------ALLC---------------------SAIFILNAGLVWFLLSKLWDLLLVRFLMGFSVLLFRSNFSLYLEE 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 353 FFQLEAAQAGYLMSFFGLLQMVTQGLV--IGQLSSHFSEEVLLRASVLVFIVVgLAMAWMSSVFHFCLLVPGLVFSLCTL 430
Cdd:cd17390  202 RFDLSPKTIGYLISYSGVLGALSGFLVgrILKLYKNNEYLLLLHSFILLALSL-LGLALAPSIWLLVLCLTPLSISSAVL 280

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 431 NVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYrSFGVPVFGHVQVAINTLVLLVLWRKP 500
Cdd:cd17390  281 RTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQ-EFSVSGPGLLGAVLALAAILLMLARQ 349
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 127-479 7.29e-21

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 94.18  E-value: 7.29e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 127 MQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLLAAASSPALpgvyLLF 206
Cdd:cd17325   14 IIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQ----LLL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 207 ASRLPGALMH-TLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCPAILAALATLLGAVLSFT 285
Cdd:cd17325   90 ARFLQGLASAaVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALL 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 286 CIPASTKGAKTdaqaplpgGPRASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMDFFQLEAAQAGYLM 365
Cdd:cd17325  170 LLPEPRPPPNK--------RAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLF 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 366 SFFGLLQMVTQGLViGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVFSLCTLNVVTDSMLIKAVSTS 445
Cdd:cd17325  242 GAQGLASALSQPPA-GKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPE 320

                        330       340       350
                 ....*....|....*....|....*....|....
gi 937500801 446 DTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVP 479
Cdd:cd17325  321 GRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFA 354
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
103-458 1.34e-20

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 93.11  E-value: 1.34e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 103 SALGRSSVILLTYVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFL 182
Cdd:COG2814    4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 183 AALALYLLLaaassPALPGVYLLFASRLPGALMHTL--PAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLV 260
Cdd:COG2814   84 LFALGSLLC-----ALAPSLWLLLAARFLQGLGAGAlfPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 261 SAYGIQCPAILAALATLLGAVLSFTCIPASTKGAKTDAQAplpggprasvfdlkAIASLLRLPDVPRIFLVKVASNCPTG 340
Cdd:COG2814  159 DLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRG--------------SLRELLRRPRLLLLLLLAFLLGFGFF 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 341 LFMVMFSIISMDFFQLEAAQAGYLMSFFGLLQMVTQgLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLV 420
Cdd:COG2814  225 ALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGA-LLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLAL 303

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 937500801 421 PGLVFSLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQ 458
Cdd:COG2814  304 FLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAF 341
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 110-501 1.36e-14

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 75.36  E-value: 1.36e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 110 VILLTYVLAATELTcLFMqfSIVPYLSRKLGLDSIA----FGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAAL 185
Cdd:cd17388    3 FILVTVLLDAMGIG-LIM--PVLPTLLREFVGDSADaathYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 186 ALYLLLAAAsspalPGVYLLFASRLPGALM-HTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGtLVSAYG 264
Cdd:cd17388   80 LDYLLMAFA-----PTLWWLYLGRIIAGITgATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGG-LLGEIS 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 265 IQCPAILAALATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPRASVFDLKAIASLLRLPDVprIFLVKVASNCPtglfMV 344
Cdd:cd17388  154 PRAPFLVAAGLNGLNFLLGLFVLPESLPPERRRAFRWRRANPFGSLRWLTGFPGLLGLLAV--FFLIQLIGQVP----AT 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 345 MFSIISMDFFQLEAAQAGYLMSFFGLLQMVTQGLVIGQLSSHFSEEVLLR----ASVLVFIVVGLA-MAWMSsvfhFCLL 419
Cdd:cd17388  228 TWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILlglaADALGFLLLAFAtQGWMV----FPIL 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 420 VPGLVFSLCTlnVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFGHVQV--AINTLVLLVLW 497
Cdd:cd17388  304 ILLALGGIAG--PALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAASPATWPGLAWIigAALYLICLVLA 381


                 ....
gi 937500801 498 RKPM 501
Cdd:cd17388  382 YRFF 385
MFS_1 pfam07690
Major Facilitator Superfamily;
111-466 1.76e-14

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 74.76  E-value: 1.76e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801  111 ILLTYVLAATELTCLFmqFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLL 190
Cdd:pfam07690   1 LFLAAFLAALGRSLLG--PALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801  191 LAAAsspalPGVYLLFASRLPGALMH--TLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQcp 268
Cdd:pfam07690  79 LLFA-----SSLWLLLVLRVLQGLGAgaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWR-- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801  269 ailaaLATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPRASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSI 348
Cdd:pfam07690 152 -----AAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801  349 isMDFFQLEAAQAGYLMSFFGLLqMVTQGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLV---F 425
Cdd:pfam07690 227 --QEVLGLSALLAGLLLGLGGLL-GAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLllgF 303

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 937500801  426 SLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGP 466
Cdd:pfam07690 304 GFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 115-473 7.30e-13

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 70.15  E-value: 7.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 115 YVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLLAAa 194
Cdd:cd06174    2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 195 sspaLPGVYLLFASRLPGALMHTL--PAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIqcpaILA 272
Cdd:cd06174   81 ----APSFWLLLLGRFLLGLGSGLidPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGF----GWR 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 273 ALATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPRASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMD 352
Cdd:cd06174  153 AVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLD 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 353 FFQLEAAQAGYLMSFFGLLQMVTQGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVFSLCTLNV 432
Cdd:cd06174  233 LGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLP 312

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 937500801 433 VTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLY 473
Cdd:cd06174  313 LSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLL 353
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
131-505 3.05e-09

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 58.74  E-value: 3.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 131 IVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAAlalylllaaasspALPGVYLLFASRL 210
Cdd:COG2223   27 LAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL-------------GIGLLLLALAVSY 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 211 PGALMH----------TLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCPAILAALATLLGA 280
Cdd:COG2223   94 WLLLLLglllgiggggSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVA 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 281 VLSFTCIPASTKGAKTDAQAPlpggprasvfdLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMDFFQLEAAQ 360
Cdd:COG2223  174 VLAWLFLRDPPAGAAAAAKAS-----------LRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAAT 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 361 AGYLMSFFGLLQMVTqGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVFSLCTL-NVVTDSMLI 439
Cdd:COG2223  243 AGLLAALFALLGALG-RPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGgNGAVFALVP 321

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 937500801 440 KAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFG-HVQVAINTLVLLVLWRKPMPQRK 505
Cdd:COG2223  322 DIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAfLVFAVLALVALVLTLLLYRRPRR 388
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
131-505 1.30e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 56.80  E-value: 1.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 131 IVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLLAaasspALPGVYLLFASRL 210
Cdd:COG2271   32 AAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFG-----FATSFWQLLLLRF 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 211 PGALMH--TLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQcpailaalatllgavlsftcip 288
Cdd:COG2271  107 LLGLGEagFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWR---------------------- 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 289 astkgaktdaqaplpggpraSVFDLKAIASLLR-LPDVPRIFLVKVASNCPTGLFMVMFSIISMDFFQLEAAQAGYLMSF 367
Cdd:COG2271  165 --------------------AAFLILGLPGLLLaLLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSL 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 368 FGLLQMVTqGLVIGQLSSHFSEE--VLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVFSLCTLNVVTDSMLIKAVSTS 445
Cdd:COG2271  225 PFLAGIVG-SLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKK 303

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 446 DTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFGHVQVAINTLVLLVLWRKPMPQRK 505
Cdd:COG2271  304 ARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 142-499 9.07e-08

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 54.16  E-value: 9.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 142 DSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLLAAASSPALPGVYLLFASRLPGALMHTL--P 219
Cdd:cd06173   32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFfgP 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 220 AAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIqcpailaaLATLLGAVLSFTCIPASTKGAKTDAQ 299
Cdd:cd06173  112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGP--------GGAFAINALSFLLSALLLLFIRRPPP 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 300 APLPGGPRASVFDLKA-IASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMDFFQLEAAQAGYLMSFFGlLQMVTQGL 378
Cdd:cd06173  184 AAPGESSSLLLRDLREgLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFG-VGALLGAL 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 379 VIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVFSLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQ 458
Cdd:cd06173  263 LLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALN 342

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 937500801 459 PLLRTLGPTVGGLLYRSFGVPVFGHVQVAINTLVLLVLWRK 499
Cdd:cd06173  343 SGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
MFS_1 pfam07690
Major Facilitator Superfamily;
328-509 2.49e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 49.72  E-value: 2.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801  328 IFLVKVASNCPTGLFMVMFSIISMDFFQLEAAQAGYLMSFFGLLQMVTQgLVIGQLSSHFSEEVLLRASVLVFIVVGLAM 407
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQ-PLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801  408 AWMSSVFHFCLLVPGLVFSLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFGHVQVA 487
Cdd:pfam07690  80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159

                         170       180
                  ....*....|....*....|..
gi 937500801  488 INTLVLLVLWRKPMPQRKDKVR 509
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPK 181
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 134-477 3.29e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 49.15  E-value: 3.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 134 YLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLLAAASSPALPGVYLLFASrLPGA 213
Cdd:cd17329   25 YLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTG-FGGG 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 214 LMHtlPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVsAYGIQCPAILAALATLLGAVLSFTCIPASTKG 293
Cdd:cd17329  104 LFE--PASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL-LYSFRLLFLAAAVLFLLAALVLLFLLPETRPK 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 294 AKTDAQAPLPGGPRASVFDlkaiasllrlpdvpRIFLvkvasncptgLFMVMFSIISMDFFQLE--------------AA 359
Cdd:cd17329  181 RRAAEKTEILRGYKIVLRD--------------RAFL----------LFLLASFLISLIYFQLEstlpvyvveilglgES 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 360 QAGYLMSFFGLLQMVTQGLVIGqLSSHFSEEVLLRASVLV----FIVVGLAMAWMSSVFHFCLLVPGLVFSLCTLNVVTD 435
Cdd:cd17329  237 LLGLLLALNALLIVLLQFPVAR-LVERFRLRKILMIGILLfaigFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVA 315

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 937500801 436 SMLIKAvstsDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFG 477
Cdd:cd17329  316 ALAPPD----KRGSYMGFYALAWGLGRAIGPLVGGLLLDLLG 353
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 218-498 5.42e-06

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 48.72  E-value: 5.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 218 LPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVsAYGIQCPAILAALATLLGAVLSFTCIPastkgaktd 297
Cdd:cd17474  105 GPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAALIPVAFLAILFLLP--------- 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 298 aqAPLPGGPRASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMDFFQLEAAQAGYLMSFFGLLQMVTQG 377
Cdd:cd17474  175 --EPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSL 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 378 LVIGQLSSHFSEEVLLRASVLVFivvGLAMAWMSSVFHFCLLVPGLVFS---LCTLNVVTDSMLIKAVSTSDTGTMLGLC 454
Cdd:cd17474  253 FVGRLLKKRFGARRILVIGLLLY---ALSLLLLGFVPSLALLLIAIVLFglgLGLNLPLLTTLVTELAPEEERGTASSLY 329

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 937500801 455 ASVQPLLRTLGPTVGGLLYRSFGVPVFGHVQVAINTLVLLVLWR 498
Cdd:cd17474  330 NFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 117-481 1.01e-05

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 47.57  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 117 LAATELTCLFMQ---FSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLLAA 193
Cdd:cd17504    1 LALAALAVMLVEtmlSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 194 AsspalPGVYLLFASR-LPGALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQcpaila 272
Cdd:cd17504   81 A-----PNLPVLIAGRaLQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWR------ 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 273 alatllgaVLSFTCIPASTKGAktdAQAPLpggprasvFDLKaiasLLRLPDVPRIFLVKVASNcpTGLFMVMFSIISM- 351
Cdd:cd17504  150 --------WIFWTAAPVAVLLA---ALVPL--------IDLR----LLRRRNVLLANITALLAG--FGMFMVFQLLPQLl 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 352 -----DFFQLEAAQAGYLMSFFGLLQMVTqGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMA---WMSSVFHFCLLVPGL 423
Cdd:cd17504  205 qlptpTGFGLGITEAGLLLLPGALVMLIA-GPLAGRLIARVGPRRVLLIGLVISAVGLLLLAllhSSLWALVVALLLIGI 283

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 937500801 424 VFSLCTLNVVTdsMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVF 481
Cdd:cd17504  284 GLGLAFASLPN--IVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTVSIT 339
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
78-248 1.66e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 46.89  E-value: 1.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801  78 VSLLRLSRMQGARAPRDQGRSPGRMSALGRSSVILLTYVLAATELTCLFMQFSIVP-YLSRKLGLDSIAFGYLQTTFGVL 156
Cdd:COG2814  176 LALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPlYLQEVLGLSASAAGLLLALFGLG 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 157 QLLGGPVFGRFADQRGARAALTLSFLAALALYLLLAAASSPALPGVYLLFASrlpGALMHTLPAAQMVITDLSAPEERPA 236
Cdd:COG2814  256 GVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLG---FGFGLLFPLLQALVAELAPPEARGR 332

                        170
                 ....*....|..
gi 937500801 237 ALGRLGLCFGVG 248
Cdd:COG2814  333 ASGLYNSAFFLG 344
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
339-498 2.36e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 46.51  E-value: 2.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 339 TGLFMVMFSIISMDFfQLEAAQAGYLMSFFGLLQMVTQgLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCL 418
Cdd:COG2814   26 IGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGA-PLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLA 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 419 LVPGLVFSLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFGVPVFGHVQVAINTLVLLVLWR 498
Cdd:COG2814  104 ARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLR 183
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 110-499 3.32e-05

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 46.05  E-value: 3.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 110 VILLTYVLAATELTCLFMqfSIVPYLSrKLGLDSIA--FGYLQTTFGVLQLLGGPVFGRFADQRG-ARAALTLSFLAALA 186
Cdd:cd17326    3 VMYLTMFLSSLQFSIVLT--SIWPYLQ-KIDPTATAsfFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 187 LYLLLAAASSPALPGVYLLFASR-LPGALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVsaygi 265
Cdd:cd17326   80 GNILYALAEYFPSNRKYVMLVARfLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFT----- 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 266 qcpailaalatllgavlsftciPASTKGAKTDAQAPL-----PGGPRASVFDLKAIASLLRLPDVPRIFlVKVASNCPTG 340
Cdd:cd17326  155 ----------------------PIGYPGYVIGIKLRFnmytaPAWLMAILGIINIILILFFFKEVVCIF-LFFVVLFIFA 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 341 LFMVMFSIISMDFFQLEAAQA----GYLMSFFGLLQMVTQGLVIGQLSSHFSEEVLLRASVLVFIVVGLamawMSSVFHF 416
Cdd:cd17326  212 NLETIGTPLTMDMYGWTREEAvlynGIILAVSGVLSVLVFLLFKFLSLGLIDERKILLGGLILFFLGFV----VTLPWGI 287

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 417 CL-LVPGLVFSLCtlNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFG-VPVFGH--VQVAINTLV 492
Cdd:cd17326  288 TGvILFGLGYPIG--NVMLYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTAIYTHFGpRWTWIItlGLLLLAIIL 365


                 ....*..
gi 937500801 493 LLVLWRK 499
Cdd:cd17326  366 LIVFYKR 372
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
109-266 4.13e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 45.63  E-value: 4.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 109 SVILLTYVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALY 188
Cdd:COG2271  181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAAL 260

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 937500801 189 LLLAAASSPALPGVYLLFAsrLPGALMH-TLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQ 266
Cdd:COG2271  261 ALLLLALLPSPALAIALLF--LAGFGLGgAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQ 337
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 98-380 1.14e-04

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 44.03  E-value: 1.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801  98 SPGRMSALGRSSVILLTYVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAAL 177
Cdd:COG0477    3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 178 TLSFLAALALYLLLAaasspALPGVYLLFASR----LPGALMhtLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGS 253
Cdd:COG0477   83 LIGLLLFGLASLLCG-----LAPSPELLIAARalqgIGAGGL--MPGALALIAELFPARERGRALGLWGAAIGLGLALGP 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 254 LLGGTLVSAYGIQCPAILAALATLLGAVLSFTcIPASTKGAKTDAQAPLPGGPRASVFDLKAIASLLRLPDVPRIFLVKV 333
Cdd:COG0477  156 LLGGLLVAALGWRWIFLINAPLGLLALVLRLR-LPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLL 234

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 937500801 334 ASNCPTGLFMVMFSIISMDFFQLEAAQAGYLMSFFGLLQMVTQGLVI 380
Cdd:COG0477  235 AGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLL 281
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 100-264 1.26e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 44.08  E-value: 1.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 100 GRMSALGRSSVILLTYVLAATELTCLFMQFS-IVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALT 178
Cdd:cd17324  189 SSLLLLLRNPRLRLAYLITFLLFGGFFALYTyLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLI 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 179 LSFLAALALYLLLAAASSPALPGVYLLFASrlpGALMHTLPAAQMVITDLsAPEERPAALGRLGLCFGVGVILGSLLGGT 258
Cdd:cd17324  269 ALLLLAAALLLLTLLGPSPLLLLVGLVLWG---LGFFAAHSALQTRVLRL-APEARGLASSLYLAAYNLGGALGAALGGL 344


                 ....*.
gi 937500801 259 LVSAYG 264
Cdd:cd17324  345 VLDHGG 350
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
231-497 1.16e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.43  E-value: 1.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 231 PEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQcPAILAALATLLGAVLSFTCIPASTKGAKtdaQAPLPGGPRASV 310
Cdd:COG2211  142 YEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGD-AALGYRLTALIFAVLGLLAFLLTFFGTK---ERPVPEEEKVSL 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 311 FDlkAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMDFFQLEAAQAGYLMSFFGLLQMVTQgLVIGQLSSHFSEE 390
Cdd:COG2211  218 KE--SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGA-PLWPRLAKRFGKK 294

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 391 VLLRASVLVFIVVGLAMAWM--SSVFHFCLLVPGLVFSLCTLNVVTDSMLIKAVSTSDTGTML---GLCASVQPLLRT-- 463
Cdd:COG2211  295 KAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRrreGLYFGIFTFAIKlg 374

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 937500801 464 --LGPTVGGLLYRSFG-VPVFGHVQVAINTLVLLVLW 497
Cdd:COG2211  375 qaLAGALAGLLLALFGyVAGAAQSPSALTGIRLLFFL 411
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 130-264 1.36e-03

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 41.07  E-value: 1.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 130 SIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADqRGARAALTLSFLAALALYLLLAaassPALPGVYLLFASR 209
Cdd:cd17328   20 GVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGD-RYNRKWILAVGILIWSAATLLS----SFAPNFWQLLLFR 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 210 lpgALMHT-----LPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYG 264
Cdd:cd17328   95 ---ALVGIgeasySPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATG 151
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 200-425 2.50e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 40.23  E-value: 2.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 200 PGVYLLFASR----LPGALMhtLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQcpailaala 275
Cdd:cd17321   82 PSLAFLIAARalqgIGAAAI--MPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWR--------- 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 276 tllgavlsftcipastkgaktdaqaplpggpraSVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIIS---MD 352
Cdd:cd17321  151 ---------------------------------WIFLINVPIGLVALLLARTFSGAVLAAFLLGAALGGLLFLLPlylQG 197

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 937500801 353 FFQLEAAQAGYLMSFFGLLQMVTqGLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHFCLLVPGLVF 425
Cdd:cd17321  198 VLGYSPLQAGLALLPLALAMLVA-APLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVL 269
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 225-500 3.43e-03

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 39.89  E-value: 3.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 225 ITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCpailaalATLLGAVLSFTCIpastkgakTDAQAPLPG 304
Cdd:cd17472  108 LADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSG-------LFLITAILSLVSL--------LILLFFVPD 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 305 GPRASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMDFFQLEAAQAGYLMSFfglLQMVTQGLVIGQLS 384
Cdd:cd17472  173 PPKIVQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVY---LPAILIGFILMVPF 249

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 385 SHFSEEVLLRASVLVFIVVGLAMAWMSSVFH---FCLLVPGLVF---SLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQ 458
Cdd:cd17472  250 VIYAEKKGKMKQVFVSSILLIAVGFLLLLFAatsLWLLIIGLIIffiGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQ 329

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 937500801 459 PLLRTLGPTVGGLLYRSFGVPVFGHVQVAINTLVLLVLWRKP 500
Cdd:cd17472  330 FLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLLVSFLLP 371
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
130-412 3.74e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 39.84  E-value: 3.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 130 SIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARaaltlSFLAALALYLLLAAASSPALPGVYLLFASR 209
Cdd:COG0738   29 PLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYK-----RGLLLGLLLMALGLLLFALAPSYPLLLLAL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 210 LPGALMHTL--PAAQMVITDLSaPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCPAILAALATLLGAVLSFTCI 287
Cdd:COG0738  104 FLLGLGLGLldVAANPYVAALG-PETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFL 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 288 PASTKGAKTDAQAPLPGGprasvfdlKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMDFFQLEAAQAGYLMSF 367
Cdd:COG0738  183 RSKLPEIEEEEEEAAGSA--------ASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSL 254

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 937500801 368 FGLLQMVTQgLVIGQLSSHFSEEVLLRASvLVFIVVGLAMAWMSS 412
Cdd:COG0738  255 FWGGMTIGR-FLGGFLLKRFGPVRLLRLS-ALLAAVGLLLALLAP 297
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 224-477 4.11e-03

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 39.56  E-value: 4.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 224 VITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAygiqcpailaalatllgavlsftcipASTKGAKTDAQAPLP 303
Cdd:cd17389  140 IVADVTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFASF--------------------------TRSLGEVFFSMPALF 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 304 GGpRASVFDLKAIASLLR--LPD-VPRIFLVkvasncpTGLFMVMFSiiSMDF---------FQLEAAQAGYLMSFFGLL 371
Cdd:cd17389  194 AL-VLALADLLFIFFFLPetLPSnLRRLGLV-------YFLYLFLFS--GLEFtltflthqrFQYTSMQQGKMFFFIGII 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 372 QMVTQGLVIGQLSSHFSEEVLLRASVLV---FIVVGlaMAWMSSVFHFCLlvpgLVFSLCTLNVVT--DSMLIKAVSTSD 446
Cdd:cd17389  264 MALVQGGYVRRIKPGKEKKAVLQGLILLipaFLLIG--WASSVTVLYAGL----FLYSFAAATVVPclTTLVSGYGSDDQ 337

                        250       260       270
                 ....*....|....*....|....*....|.
gi 937500801 447 TGTMLGLCASVQPLLRTLGPTVGGLLYRSFG 477
Cdd:cd17389  338 KGTVMGIFRSLGALARALGPIVACTVYWLAG 368
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
340-477 5.33e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 39.08  E-value: 5.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937500801 340 GLFMVMFSIIS---MDFFQLEAAQAGYLMSFFGLLQMVTQgLVIGQLSSHFSEEVLLRASVLVFIVVGLAMAWMSSVFHF 416
Cdd:COG2271   23 YLDRSNLSVAApplQADLGLSAAQLGLLASAFFLGYALGQ-IPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQL 101

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 937500801 417 CLLVPGLVFSLCTLNVVTDSMLIKAVSTSDTGTMLGLCASVQPLLRTLGPTVGGLLYRSFG 477
Cdd:COG2271  102 LLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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