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Conserved domains on  [gi|939320314|ref|NP_001303284|]
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COP9 signalosome complex subunit 3 isoform 4 [Homo sapiens]

Protein Classification

PCI domain-containing protein( domain architecture ID 12188609)

PCI (proteasome-COP9/CSN-initiation factor) domain-containing protein is a component of multiprotein complexes; similar to eukaryotic translation initiation factor 3 subunits A and M, and Schizosaccharomyces pombe Cop9 signalosome complex subunit 4

Gene Ontology:  GO:0032991|GO:0032991
PubMed:  9644972|36094910|19683491|11495792
SCOP:  4000147

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
 251-325 1.96e-13

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


:

Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 65.34  E-value: 1.96e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 939320314   251 RFIKTFLTLSLQDMASRVQLSGPqEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNNPamLHNIDQEMLKC 325
Cdd:smart00088  17 QLSEPYSSISLSDLAKLLGLSVP-EVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPRRSEP--LAQFAETLKKL 88
 
Name Accession Description Interval E-value
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
 251-325 1.96e-13

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 65.34  E-value: 1.96e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 939320314   251 RFIKTFLTLSLQDMASRVQLSGPqEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNNPamLHNIDQEMLKC 325
Cdd:smart00088  17 QLSEPYSSISLSDLAKLLGLSVP-EVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPRRSEP--LAQFAETLKKL 88
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
 220-304 9.35e-10

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 55.30  E-value: 9.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939320314  220 MLESYKKYILVSLILLGKVQQLP-KYTSQIVGRFIKTFLTLSLQDMASRVQLSGpQEAEKYVLHMIEDGEIFASINQKDG 298
Cdd:pfam01399  21 ILADYKEELLLDDGLAEHLEDLRrKIREHNLRQLSKPYSSISLSDLAKLLGLSV-DEVEKILAKLIRDGRIRAKIDQVNG 99


                  ....*.
gi 939320314  299 MVSFHD 304
Cdd:pfam01399 100 IVVFSK 105
 
Name Accession Description Interval E-value
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
 251-325 1.96e-13

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 65.34  E-value: 1.96e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 939320314   251 RFIKTFLTLSLQDMASRVQLSGPqEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNNPamLHNIDQEMLKC 325
Cdd:smart00088  17 QLSEPYSSISLSDLAKLLGLSVP-EVEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPRRSEP--LAQFAETLKKL 88
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
 220-304 9.35e-10

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 55.30  E-value: 9.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939320314  220 MLESYKKYILVSLILLGKVQQLP-KYTSQIVGRFIKTFLTLSLQDMASRVQLSGpQEAEKYVLHMIEDGEIFASINQKDG 298
Cdd:pfam01399  21 ILADYKEELLLDDGLAEHLEDLRrKIREHNLRQLSKPYSSISLSDLAKLLGLSV-DEVEKILAKLIRDGRIRAKIDQVNG 99


                  ....*.
gi 939320314  299 MVSFHD 304
Cdd:pfam01399 100 IVVFSK 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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