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Conserved domains on  [gi|948284190|ref|NP_001303808|]
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ST3 beta-galactoside alpha-2,3-sialyltransferase 8 [Latimeria chalumnae]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 57-332 0e+00

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


:

Pssm-ID: 467694  Cd Length: 276  Bit Score: 528.00  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190  57 CEKCVSEKEESAWFDERFDPNFQPILMTEVQDIPSHALQWWLVQAGNKNYNLSESIAKLFTVVPRTNHSGIRDPAHCRKC 136
Cdd:cd23966    1 CRRCVQEGGDSDWFDERFNPSIEPLLTRKNKELPPDVLKWWLSLQSSKNSDLREVLEKLFQVVPGENPYRTRDPNRCRRC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 137 AVVGNSGNLKGSNHGKEIDAHHFVIRMNRARTAGFEPDVGIKTTHHLMYPESSQDLQPGVHLVLLPFKIMDFEWIRSALT 216
Cdd:cd23966   81 AVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESAVDLDPGVHLVLVPFKVLDLQWLISALT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 217 TGEITRTYFRVQQFIKADKDKVLIINPTFFKYVCDHWTEHHGRYPSTGMTALVFALHICDEVSVFGYGADSNGNWHHYWE 296
Cdd:cd23966  161 TGEITRTYTPVKRFIKADKDKVLVINPAFIKYVHDNWTEHHGRYPSTGFLALIFALHICDEVSVFGFGADSKGNWHHYWE 240

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 948284190 297 NNRNGGAFRRTGVHSGDFESQIIKKLADEGKIIFYK 332
Cdd:cd23966  241 KNRSAGAFRKTGVHDADFESDIIKKLAKEGKIRVYR 276
 
Name Accession Description Interval E-value
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 57-332 0e+00

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 528.00  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190  57 CEKCVSEKEESAWFDERFDPNFQPILMTEVQDIPSHALQWWLVQAGNKNYNLSESIAKLFTVVPRTNHSGIRDPAHCRKC 136
Cdd:cd23966    1 CRRCVQEGGDSDWFDERFNPSIEPLLTRKNKELPPDVLKWWLSLQSSKNSDLREVLEKLFQVVPGENPYRTRDPNRCRRC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 137 AVVGNSGNLKGSNHGKEIDAHHFVIRMNRARTAGFEPDVGIKTTHHLMYPESSQDLQPGVHLVLLPFKIMDFEWIRSALT 216
Cdd:cd23966   81 AVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESAVDLDPGVHLVLVPFKVLDLQWLISALT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 217 TGEITRTYFRVQQFIKADKDKVLIINPTFFKYVCDHWTEHHGRYPSTGMTALVFALHICDEVSVFGYGADSNGNWHHYWE 296
Cdd:cd23966  161 TGEITRTYTPVKRFIKADKDKVLVINPAFIKYVHDNWTEHHGRYPSTGFLALIFALHICDEVSVFGFGADSKGNWHHYWE 240

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 948284190 297 NNRNGGAFRRTGVHSGDFESQIIKKLADEGKIIFYK 332
Cdd:cd23966  241 KNRSAGAFRKTGVHDADFESDIIKKLAKEGKIRVYR 276
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 92-327 8.04e-96

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 284.50  E-value: 8.04e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190   92 HALQWWLvqagnkNYNLSESIAKLFtvvPRTNHsgiRDPAHCRKCAVVGNSGNLKGSNHGKEIDAHHFVIRMNRARTAGF 171
Cdd:pfam00777  14 RYSEWWL------PFTVTEELLELL---PKVSP---FDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190  172 EPDVGIKTTHHLMYPES-----------SQDLQPGVHLVLLPFKIMDFEWIRSALTTGEITR----TYFRVQQFIKADKD 236
Cdd:pfam00777  82 EKDVGSKTTLRTMNPESaidskygnlgfSHPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRslrvLYTLKEVKIPVDPD 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190  237 KVLIINPTFFKYVCDHWTEHHG---RYPSTGMTALVFALHICDEVSVFGYGA--DSNGNWHHYWENNRNgGAFRRTGVHS 311
Cdd:pfam00777 162 KVLFLHPDFLRYVANFWLRSHGlkgRRPSTGLLMLSLALHLCDEVSLYGFGPflDSRGNSHHYYDNVLM-KKGGFYGVHD 240

                         250
                  ....*....|....*.
gi 948284190  312 GDFESQIIKKLADEGK 327
Cdd:pfam00777 241 MPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 57-332 0e+00

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 528.00  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190  57 CEKCVSEKEESAWFDERFDPNFQPILMTEVQDIPSHALQWWLVQAGNKNYNLSESIAKLFTVVPRTNHSGIRDPAHCRKC 136
Cdd:cd23966    1 CRRCVQEGGDSDWFDERFNPSIEPLLTRKNKELPPDVLKWWLSLQSSKNSDLREVLEKLFQVVPGENPYRTRDPNRCRRC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 137 AVVGNSGNLKGSNHGKEIDAHHFVIRMNRARTAGFEPDVGIKTTHHLMYPESSQDLQPGVHLVLLPFKIMDFEWIRSALT 216
Cdd:cd23966   81 AVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESAVDLDPGVHLVLVPFKVLDLQWLISALT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 217 TGEITRTYFRVQQFIKADKDKVLIINPTFFKYVCDHWTEHHGRYPSTGMTALVFALHICDEVSVFGYGADSNGNWHHYWE 296
Cdd:cd23966  161 TGEITRTYTPVKRFIKADKDKVLVINPAFIKYVHDNWTEHHGRYPSTGFLALIFALHICDEVSVFGFGADSKGNWHHYWE 240

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 948284190 297 NNRNGGAFRRTGVHSGDFESQIIKKLADEGKIIFYK 332
Cdd:cd23966  241 KNRSAGAFRKTGVHDADFESDIIKKLAKEGKIRVYR 276
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 55-332 6.00e-135

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 384.61  E-value: 6.00e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190  55 CSCEKCVSEKEESAWFDERFDPNFQPILMTEVQDIPSHALQWWL-VQAGNKNYNLSESIAKLFTVVPRTNHSGIRDPAHC 133
Cdd:cd23979    1 CACRRCVGDPGVSDWFDEHYDPDISPVWTKENMELPPDVQYWWMmLQPQFKPHNTKEVLSKLFQIIPGENPYRSWDPSRC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 134 RKCAVVGNSGNLKGSNHGKEIDAHHFVIRMNRARTAGFEPDVGIKTTHHLMYPESSQDLQPGVHLVLLPFKIMDFEWIRS 213
Cdd:cd23979   81 RRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLPANVSFVLVPFKTLDLLWITS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 214 ALTTGEITRTYFRVQQFIKADKDKVLIINPTFFKYVCDHWTEHHGRYPSTGMTALVFALHICDEVSVFGYGADSNGNWHH 293
Cdd:cd23979  161 ALSTGQIRFTYAPVKQFLRVDKDKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWHH 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 948284190 294 YWENNRNGGAFRRTGVHSGDFESQIIKKLADEGKIIFYK 332
Cdd:cd23979  241 YWENNRYAGEFRKTGVHDADFEAHIIDMLAKAGKIKVYR 279
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 55-332 1.24e-123

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 356.11  E-value: 1.24e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190  55 CSCEKCVSEKEESAWFDERFDPNFQPILMTEVQDIPSHALQWWL-VQAGNKNYNLSESIAKLFTVVPrtnhsGIRDP--- 130
Cdd:cd23980    1 CTCTTCIEEQRVSAWFDERFNRS*QPLLTAQNAHLEEDTYKWWLrLQREKKPKNLNDTIRELFQVVP-----GNVDPlle 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 131 ---AHCRKCAVVGNSGNLKGSNHGKEIDAHHFVIRMNRARTAGFEPDVGIKTTHHLMYPESSQDLQPGVHLVLLPFKIMD 207
Cdd:cd23980   76 krlVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFRELAQNVSMILVPFKTLD 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 208 FEWIRSALTTGEITRTYFRVQQFIKADKDKVLIINPTFFKYVCDHWTEHHGRYPSTGMTALVFALHICDEVSVFGYGADS 287
Cdd:cd23980  156 LEWVISATTTGTISHTYVPVPRKIKVKKEKILIYHPAFIKYVFDRWLQGHGRYPSTGILSVIFSLHVCDEVDLYGFGADS 235

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 948284190 288 NGNWHHYWENNRNGGAFRRTGVHSGDFESQIIKKLADEGKIIFYK 332
Cdd:cd23980  236 KGNWHHYWENNPSAGAFRKTGVHDGDFESNVTTILASINKIRIFK 280
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 92-327 8.04e-96

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 284.50  E-value: 8.04e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190   92 HALQWWLvqagnkNYNLSESIAKLFtvvPRTNHsgiRDPAHCRKCAVVGNSGNLKGSNHGKEIDAHHFVIRMNRARTAGF 171
Cdd:pfam00777  14 RYSEWWL------PFTVTEELLELL---PKVSP---FDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190  172 EPDVGIKTTHHLMYPES-----------SQDLQPGVHLVLLPFKIMDFEWIRSALTTGEITR----TYFRVQQFIKADKD 236
Cdd:pfam00777  82 EKDVGSKTTLRTMNPESaidskygnlgfSHPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRslrvLYTLKEVKIPVDPD 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190  237 KVLIINPTFFKYVCDHWTEHHG---RYPSTGMTALVFALHICDEVSVFGYGA--DSNGNWHHYWENNRNgGAFRRTGVHS 311
Cdd:pfam00777 162 KVLFLHPDFLRYVANFWLRSHGlkgRRPSTGLLMLSLALHLCDEVSLYGFGPflDSRGNSHHYYDNVLM-KKGGFYGVHD 240

                         250
                  ....*....|....*.
gi 948284190  312 GDFESQIIKKLADEGK 327
Cdd:pfam00777 241 MPFEFKLLQKLHKEGV 256
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 136-322 4.69e-50

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 165.23  E-value: 4.69e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 136 CAVVGNSGNLKGSNHGKEIDAHHFVIRMNRARTAGFEPDVGIKTTHHLMYPESSQDLQPGVHLVLLPFKIMdfEWIRSAL 215
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGCHPLPLE--EEVVLIL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 216 TTGEiTRTYFRVQQFIKADKDKVLIINPT---FFKYVCDHWTEHH------GRYPSTGMTALVFALHICDEVSVFGYGAD 286
Cdd:cd19952   79 SRAA-AADFKRLKRRKKRHDNAVLLLTDPapdLLSYVRKRLEKLGlksffgGNAPSSGLLAVLLALQLCDSVDLYGFGVD 157

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 948284190 287 SN---GNWHHYWENNRNGgafRRTGVHSGDFESQIIKKL 322
Cdd:cd19952  158 SGhapKVPYHYYDLVEAE---EGTAVHSFDLEAELLRAL 193
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 65-332 4.00e-46

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 158.19  E-value: 4.00e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190  65 EESAWFDERFDPNFqPILMTevqdiPSHA-------LQWWLVQAGNKNYNLSEsIAKLFTVVPRTNH----SGIRDPAHC 133
Cdd:cd23964   10 QKSPWFRERFIPDI-KVLLD-----SEDFnpeeynrLSHYKLPFGWGGLNREV-VERLLRNLNLTSSrymfVLRGGRPRC 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 134 RKCAVVGNSGNLKGSNHGKEIDAHHFVIRMNRARTAGFEPDVGIKTTHHLMYPESSQDLQPGVHL-------VLLPFKIM 206
Cdd:cd23964   83 IRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPESLHNSLLKHVPqdkdtkyLFIPFKIR 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 207 DFEWIRSALT-----TGEITRTYFRVQQFIKADKDKVLIINPTFFKYVCDHWTEHH-GRYPSTGMTALVFALHICDEVSV 280
Cdd:cd23964  163 DYDYLDAVLSgkpvpDGCDKGKRPPPLFGPKLNATNVRLLHPDFIRYLFNRWLNSStSYRPTTGALMLLTALHTCDQVSV 242

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 948284190 281 FGYGADSNGNwHHYWENnrnggAFRR----TGVHSGDFESQIIKKLADEGKIIFYK 332
Cdd:cd23964  243 YGFGYDPRFS-LHYYDK-----TFVKftvfYANHDFTNERKLWRKLHEEGIINLYR 292
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 133-322 1.41e-45

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 154.05  E-value: 1.41e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 133 CRKCAVVGNSGNLKGSNHGKEIDAHHFVIRMNRARTAGFEPDVGIKTTHHLMYPESSQ-----DLQPGVHLVLLPFKIMD 207
Cdd:cd23982    2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQfdpgiENDPDTLLVLVPFKPLD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 208 FEWIRSALTTGEITRTYF--RVQQFIKADKDKVLIINPTF-----FKYVCDHWTEHHGRYPSTGMTALVFALHICDEVSV 280
Cdd:cd23982   82 FYWLYEILSNEKRVRKGFwkQPPRIWDANPKQIRILNPYYtyvaaTKLLQVPGQRKKKQKPTTGLLAITLALHLCDEVHI 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 948284190 281 FGYGADSNGN---WHHYWennrNGGAFRRTGVHSGDF--ESQIIKKL 322
Cdd:cd23982  162 AGFGYPDNGNsnqPIHYY----NQITLKSMANSGHNLnaEAQAIQRL 204
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 133-322 4.38e-44

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 150.13  E-value: 4.38e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 133 CRKCAVVGNSGNLKGSNHGKEIDAHHFVIRMNRARTAGFEPDVGIKTTHHLMYPESS----QDLQPGVHLVLLPFKIMDF 208
Cdd:cd23967    2 CRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAfrdpEEYDSDWLLVLVPFKSMDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 209 EWIRSALTTGEITRTYFR---VQQFIKADKDKVLIINPTFFKYVcdhwTEHHGRY----------PSTGMTALVFALHIC 275
Cdd:cd23967   82 LWLQAVIKGKKPNGKGGFwkkIATSVPKPPKKIRILNPYILQEA----AFDLIGLpmngkqgknvPTTGIIAIVMALHYC 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 948284190 276 DEVSVFGYGADSN--GNWHHYWEnNRNGGAFRRTGVHSGDFESQIIKKL 322
Cdd:cd23967  158 DEVDIAGFGYDPSdpNAPLHYYD-SLTMKAIKRSWTHNVTKEKKYLKKL 205
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 132-322 9.54e-34

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 123.31  E-value: 9.54e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 132 HCRKCAVVGNSGNLKGSNHGKEIDAHHFVIRMNRARTAGFEPDVGIKTTHHLMYPE----SSQDLQPGVHLVLLPFKIMD 207
Cdd:cd23983    1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEgapkSEQEYDPTSLFVAVLFKSVD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 208 FEWIRSALTTGEIT---RTYF--RVQQFIKADKDKVLIINPTFFK---YVCDHWTEHHGRY-------PSTGMTALVFAL 272
Cdd:cd23983   81 FAWLKAMVKKEPLSfwsRLFFwkEVADSIPLKPSQFRILNPLIIKetaLDILQYPEPQSRLwgwdknvPTLGVTAVVLAT 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 948284190 273 HICDEVSVFGYGADSN--GNWHHYWEnNRNGGAFRRTGVHSGDFESQIIKKL 322
Cdd:cd23983  161 HLCDEVSLAGFGYDLSqpHAPLHYYD-SVCMAAMNTQTMHNVTKETKFLKKL 211
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 133-297 3.44e-31

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 116.38  E-value: 3.44e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 133 CRKCAVVGNSGNLKGSNHGKEIDAHHFVIRMNRARTAGFEPDVGIKTTHHLMYPES----SQDLQPGVHLVLLPFKIMDF 208
Cdd:cd23984    2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESifsdPSHYDPNTTVVLIPFKPHDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 209 EWIRSALTTGEITRTYFRVQQFIKA--DKDKVLIINPTFFKYVC--------DHWTEHHGRYPSTGMTALVFALHICDEV 278
Cdd:cd23984   82 RWLLDLLMGKKVSAKGFWKKPALNLiyKPNQIRILNPFILRIAAyellhfpkRFPKEKKPKHPTTGIIAITLALHICNEV 161

                        170       180
                 ....*....|....*....|.
gi 948284190 279 SV--FGYGADSNGNWHHYWEN 297
Cdd:cd23984  162 HIagFKYDFSNLNSTLHYYGN 182
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 103-328 4.49e-31

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 118.13  E-value: 4.49e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 103 NKNYNLSESIAKLFtvvPRTNHsgIRDPAHcRKCAVVGNSGNLKGSNHGKEIDAHHFVIRMNRARTAGFEPDVGIKTTHH 182
Cdd:cd23963   39 KKTFKITKSLYELL---PKTSP--FSHKRY-KTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNLT 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 183 LMYPESsqdlqpgVHLVLLPFKIMDFE---------------WIrSALTTGEITRTYFRVQQFIKADKD--KVLIINPTF 245
Cdd:cd23963  113 TLNPSI-------LKRRYNSLKKNRDRdkflnrlkeyngsilWY-PKFSFKSSTNLLLKAARALKKNGLnlTVVYSNPEH 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 246 FKYVCDHWTEHHG-RYPSTGMTALVFALHICDEVSVFG---YGADSNGNW--HHYWENNRNGGAfrrTGVHSGDFESQII 319
Cdd:cd23963  185 FLAVQKFWKRRGLeKRPSTGLYLVSLALTFCDEIHLYGfwpFPTDPNGRPvpYHYYDDLSPSTK---NKVHNMPEEFKLL 261


                 ....*....
gi 948284190 320 KKLADEGKI 328
Cdd:cd23963  262 RELHKKGVL 270
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 62-331 1.57e-27

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 109.46  E-value: 1.57e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190  62 SEKEESAWFDERFDPNFQPILMTEVQDIPshalQWWLVQAGNK-------NYNLSESIAKLFTVVPR----TNHSGIRDp 130
Cdd:cd23973    7 SKAAKSDWFKKLFLPNITLFLDKDHFNMS----EWDRLEHFNPpfgfmglNYTLVKEVVELIPKPKEqqllALSPPGGD- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 131 aHCRKCAVVGNSGNLKGSNHGKEIDAHHFVIRMNRARTAGFEPDVGIKT-----THHLMYpESSQDLQ----------PG 195
Cdd:cd23973   82 -GCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTsfyvhTAHSIT-SSLMILQkrgfknipqdKD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 196 VHLVLLPFKIMDFEWIRSALT---------TGEITRTYFRvQQFikaDKDKVLIINPTFFKYVCDHW-------TEHHGR 259
Cdd:cd23973  160 IKYILFPEGPRDYQWLEALLKnktipsgayYGRRPRSYFS-GDF---TEDKYLVLHPDFLRYVKNRFlrsktlkGKYWAI 235

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 948284190 260 Y-PSTGMTALVFALHICDEVSVFGY-GADSNGNWHHYWENNRNGGAFrrTGVHSGDFESQIIKKLADEGKIIFY 331
Cdd:cd23973  236 YrPTTGAFLLLTALHLCDTVSAYGFiTEDYRKYPDHYYDKKKTKLVF--YINHDFRLEKKLWKRLHDEKIIKLY 307
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 133-322 1.17e-26

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 104.62  E-value: 1.17e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 133 CRKCAVVGNSGNLKGSNHGKEIDAHHFVIRMNRARTAGFEPDVGIKTTHHLMYPESS----QDLQPGVHLVLLPFKIMDF 208
Cdd:cd23981    2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAiqkpEQYEKDSLFVLAGFKWQDF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 209 EWIRSALTTGEITRT---YFRVQQFIKADKDKVLIINPTF-----FKYV---CDHWTEHHGRYPSTGMTALVFALHICDE 277
Cdd:cd23981   82 KWLKYIVYKEKVSASdgfWKSVATRVPREPHEIRILNPYFiqeaaFSFIglpFNNGLMGRGNIPTLGSVAITMALHNCDE 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 948284190 278 VSVFGYGADSNGNWH--HYWENNRNgGAFRRTGVHSGDFESQIIKKL 322
Cdd:cd23981  162 VAVAGFGYDMNTPNAplHYYETIKM-SAIKESWTHNIQREKEFLRKL 207
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 128-332 2.15e-25

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 103.36  E-value: 2.15e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 128 RDPAHCRKCAVVGNSGNLKGSNHGKEIDAHHFVIRMNRARTAGFEPDVGIKTTHH-----------LMYPESSQDLQP-- 194
Cdd:cd23972   77 DTPGKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTSFYgftvntmknslISYWNLGFTRTPqg 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 195 -GVHLVLLPFKIMDFEWIRSA---------LTTGEITRTYFRvqqfIKADKDKVLIINPTFFKYVCDHW-------TEHH 257
Cdd:cd23972  157 qDLQYIFIPSDIRDYVMLRSAilgvpvpegLDKGDRPHKYFG----PEASAKKFKLLHPDFISYLTDRFlkskllnTHYG 232

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 948284190 258 GRY-PSTGMTALVFALHICDEVSVFGY-GADSNGNWHHYWENNRNGGAFRRTgvHSGDFESQIIKKLADEGKIIFYK 332
Cdd:cd23972  233 HLYmPSTGALMLLTALHTCDQVSAYGFiTSNYWKFSDHYYERKKKPLVFYAN--HDMLLEAALWRRLHKAGILQLYQ 307
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 133-331 3.45e-24

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 100.21  E-value: 3.45e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 133 CRKCAVVGNSGNLKGSNHGKEIDAHHFVIRMNRARTAGFEPDVGIKTTHH------LMY------------PESSQDLQp 194
Cdd:cd23974   84 CIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYtfstntLMNslrayagvgfngPPQSKETR- 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 195 gvhLVLLPFKIMDFEWIRSALTTGEITR---------TYFRvqqfIKADKDKVLIINPTFFKYVCDHW-------TEHHG 258
Cdd:cd23974  163 ---YIFLPDHDRDYLLVKAALTHTPIDRgrdkskrpsKYFG----KDVTAEKFKIYHPDFIRYLRNRFlwspilnTKQRD 235

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 948284190 259 RY-PSTGMTALVFALHICDEVSVFG-----YGADSNgnwhHYWENNRNGGAFRRTgvHSGDFESQIIKKLADEGKIIFY 331
Cdd:cd23974  236 IYrPSTGAVMLLAALHTCDQVSAYGfmtpdYGKYSD----HYYDKTYHKVVFYAN--HDLRLEMQLWQKLHKAGLIKLY 308
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 134-323 5.05e-24

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 98.88  E-value: 5.05e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 134 RKCAVVGNSGNLKGSNHGKEIDAHHFVIRMNRARTAGFEPDVGIKTTHHLMypeSSQDL-QPGVHLVLLP--FKIMDFEW 210
Cdd:cd23968   46 NTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRLI---NSQILsKPEFNFLTDPlyRNVTLLVW 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 211 iRSALTTGEITRTYFRVQQ-----FIKA----DKDKVLIINPTFFKYVCD---HWTEH--HGRYPSTGMTALVFALHICD 276
Cdd:cd23968  123 -DPSSYNVNLEKWYKKPDFdffpnYIKYrrrhPEEPFYLIDPRFLWRLWDilqEYTPEkiKPNPPSSGFIGIVLMLHLCD 201

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 948284190 277 EVSVFGYgADSNGNWH--HYWEN----NRNGGAFrrtgvHSGDFESQIIKKLA 323
Cdd:cd23968  202 WVDVYEY-VPSVRQTDrcHYYDVekdlACTLGAW-----HPLAAEKLLVRHLN 248
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 133-299 3.92e-21

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 89.99  E-value: 3.92e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 133 CRKCAVVGNSGNLKGSNHGKEIDAHHFVIRMNRARTAGFEPDVGIKTTHHLMYPESSQDL------------QPGVHLVL 200
Cdd:cd23965    1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVSHSSLPRLlrnailllagtrAPTVVVFW 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 201 LPFKIMDFEWIRSALTTGEITRTYFRVqQFIKADKDKVLIINPTFFKYvcdhwTEHH----GRYPSTGMTALVFALHICD 276
Cdd:cd23965   81 GPETKMNKDGAGKYNLLRSLSKKYPDV-EFYSLTPEKMDYADELFEKE-----TGKSriksGTWLSTGWFTMLLALDVCD 154

                        170       180       190
                 ....*....|....*....|....*....|...
gi 948284190 277 EVSVFGYgadSNGNW----------HHYWENNR 299
Cdd:cd23965  155 EIKVYGM---VPENYcrehpnskvpYHYYEPGG 184
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 132-326 9.48e-21

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 90.17  E-value: 9.48e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 132 HCRKCAVVGNSGNLKGSNHGKEIDAHHFVIRMNRARTAGFEPDVGIKTTHHLMYPESSQ----DLQPG------VH-LVL 200
Cdd:cd23969   63 HFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSVIPhaygDLVNAtdkekfVErLRQ 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 201 LPFKIMdfeWIRSALTTGEiTRTYFRVQQFIKADKDKVLIINPT--FFKYVCDHW--TEHHGRYPSTGMTALVFALHICD 276
Cdd:cd23969  143 LGDSIL---WIPAFVSKGG-EEHVQWTNEIILKHKLNVKTAYPPlrLNHAIRGYWltTKFRIKRPSTGLLMYTLATRFCD 218

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 948284190 277 EVSVFGY---GADSNG---NWHHYweNNRNGGAFRRTgvHSGDFESQIIKKLADEG 326
Cdd:cd23969  219 EIHLYGFypfSEDGNGravKYHYY--DNRKYLTTARP--HKMPEEFRALRSLHQRG 270
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 134-328 1.80e-18

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 83.85  E-value: 1.80e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 134 RKCAVVGNSGNLKGSNHGKEIDAHHFVIRMNRARTAGFEPDVGIKTTHHLMYPESSQ----------DLQPGVH-LVLLP 202
Cdd:cd23988   65 KTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQrafggfrnesDREKFVHrLSMLN 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 203 FKIMdfeWIRSALTTGEITRTYFrVQQFIKADKDKVLIINPT--FFKYVCDHWTEH--HGRYPSTGMTALVFALHICDEV 278
Cdd:cd23988  145 DSVL---WIPAFMVKGGEKHVEW-VNALILKNKLKVRTAYPSlrLIHAVRGYWLTNkvNIKRPSTGLLMYTLATRFCDEI 220

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 948284190 279 SVFG---YGADSNGN--WHHYWENNRNgGAFRRTGVHSGDFESQIIKKLADEGKI 328
Cdd:cd23988  221 HLYGfwpFPKDANGNpvKYHYYDDLKY-RYFSNAGPHRMPLEFKTLNVLHNRGAL 274
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 135-311 1.73e-17

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 80.76  E-value: 1.73e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 135 KCAVVGNSGNLKGSNHGKEIDAHHFVIRMNRARTAgFEPDVGIKTT-------------HHLMYP-----ESSQdlQPGV 196
Cdd:cd23971   66 TCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKTNlvtanpsilrekfHNLKKRrrpfvERMK--VYGN 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 197 HLVLLPfkimdfewirsALTTGEIT----RTYFRVQQFikADKDKVLIINPTFFKYVCDHWTEH--HGRYPSTGMTALVF 270
Cdd:cd23971  143 ALLLLP-----------AFSYTSNTepslRALYTLEDF--GSPQKVLFFNPEYLRNLSRYWKSKglKARRLSTGLMLVSA 209

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 948284190 271 ALHICDEVSVFG---YGADSNGNW--HHYWENNRNGGafrrtGVHS 311
Cdd:cd23971  210 ALELCENVHLYGfwpFSTDLDGNPisHHYYDNVLPKK-----GVHA 250
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 133-330 1.33e-16

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 77.59  E-value: 1.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 133 CRKCAVVGNSGNLKGSNHGKEIDAHHFVIRMNRARTAGFEPDVGIKTTHHLM-----------YPESSQDLQPGVHLVLL 201
Cdd:cd23977    1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVshtsvplllrnQGYFFQQSRDTKYVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 202 PFKIMDFE----WIRSALTTgeiTRTYFRVQqfikadkdkVLIINPTFFKYvCDHWTEHH--------GRYPSTGMTALV 269
Cdd:cd23977   81 PERNMDRDgggkTYRALLTL---AKMYPHLQ---------VYTLTEEKMAY-CDGVFQNEtgknrmksGSFLSTGWFTMI 147

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 948284190 270 FALHICDEVSVFGYGADS---NGNW----HHYWENNR---------NGGAFRrtGVHSGDFESQIIKKLADEGKIIF 330
Cdd:cd23977  148 LALELCEEILVYGMVSDSycrNKNHssvpYHYYEKGRldecrmylvHERAPR--GGHRFITEKAIFSRWAKRKKIRF 222
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 134-297 1.04e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 76.02  E-value: 1.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 134 RKCAVVGNSGNLKGSNHGKEIDAHHFVIRMN-RARTAGFEPDVGIKTthHLMYPESS------QDLQPGVHLVLLPFKIM 206
Cdd:cd23989   64 KKCSVVGNGGILKNSGCGQQIDRADFVMRCNlPPLSREYTDDVGTKT--QLVTANPSiidkrfQNLLWSRKSFVESMKVY 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 207 DFEWI-----RSALTTGEITRTYFRVQQFikADKDKVLIINPTFFKYVCDHWTEH--HGRYPSTGMTALVFALHICDEVS 279
Cdd:cd23989  142 GRSYIympafSMKTGTDPSLRVYYTLADV--GANQTVLFANPNFLRNVGKFWKSKgvHAKRLSTGLFLVSAALGLCEEVT 219

                        170       180
                 ....*....|....*....|...
gi 948284190 280 VFGY-----GADSNGNWHHYWEN 297
Cdd:cd23989  220 IYGFwpfsvDLDERTISHHYYDN 242
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 111-326 1.13e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 75.89  E-value: 1.13e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 111 SIAKLFTVVPRTNHSGIRDPA-----HCRKCAVVGNSGNLKGSNHGKEIDAHHFVIRMNRARTAGFEPDVGIKTTHHLMY 185
Cdd:cd23970   41 SSHKYVFSISPNLRSLLPEVSpfqnkHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFN 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 186 PESsqdLQPGVHLVLLPFKIMDFE-----------WI------RSALTTGeiTRTYFRVQQfiKADKDKVLIINPTFFKY 248
Cdd:cd23970  121 PSI---LEKYYNNLLTIQDRNNFFlslkkldgailWIpafffhTSATVTR--TLVDFFVEH--RGQLKVQLAWPGNIMQH 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 249 VCDHWTEHHG--RYPSTGMTALVFALHICDEVSVFG---YGADSNGNW--HHYWENNRNGGAFRRTGVHSGDFESQIIKK 321
Cdd:cd23970  194 VNRYWKTKHLspKRLSTGILMYTLASAICEEIHLYGfwpFGFDPTGTPlpYHYYDKKGTKFTTKWQESHQLPAEFVLLYK 273


                 ....*
gi 948284190 322 LADEG 326
Cdd:cd23970  274 MHGAG 278
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 107-328 1.73e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 72.66  E-value: 1.73e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 107 NLSESiakLFTVVPRTnhSGIRDpAHCRKCAVVGNSGNLKGSNHGKEIDAHHFVIRMNRARTAGFEPDVGIKTTHHLMYP 186
Cdd:cd23987   44 NISQN---LYELLPRT--SPLKN-KHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNP 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 187 ESSQDlqpgvhlvllPFK-IMDFEWIRSALTT-GEITRTYFRVQQFI-KADKDKVLIINPTFFKY--------------- 248
Cdd:cd23987  118 SVVQR----------AFEdLVNETWKEKFLQRlQSLNGSILWIPAFMaKGGEERVEWVNDLILKHhinvrtaypslrllh 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 249 -VCDHW-TEH-HGRYPSTGMTALVFALHICDEVSVFG---YGADSNGN--WHHYWENNRNGGAfRRTGVHSGDFESQIIK 320
Cdd:cd23987  188 aVRGYWlTNKvHIKRPTTGLLMYTLATRFCNRIHLYGfwpFPRDQNQNpvKYHYYDSLKYGYT-SQASPHTMPLEFKALK 266


                 ....*...
gi 948284190 321 KLADEGKI 328
Cdd:cd23987  267 NLHQQGAL 274
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 80-184 2.87e-14

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 71.66  E-value: 2.87e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190  80 PILMTEVQDIPSHALQWwlvqagnKNYNLSESIAKLFtvvprtnhsgirdpAHCRKCAVVGNSGNLKGSNHGKEIDAHHF 159
Cdd:cd23985   13 NVSMLEGTDFPFNTSEW-------EGYLPKKSLREEV--------------GPLGRCAVVSSAGSLKSSGLGREIDSHDA 71

                         90       100
                 ....*....|....*....|....*
gi 948284190 160 VIRMNRARTAGFEPDVGIKTTHHLM 184
Cdd:cd23985   72 VLRFNGAPTAGFQQDVGTKTTIRLI 96
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 104-297 1.76e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 69.40  E-value: 1.76e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 104 KNYNLSESIAKLFtvvPRTnhSGIRDPAHcRKCAVVGNSGNLKGSNHGKEIDAHHFVIRMNRARTAG-FEPDVGIKTthH 182
Cdd:cd23991   41 KKILITENIFRMF---PKS--QPFRGYPY-KQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKT--N 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 183 LM----------YPESSQDLQP--------GVHLVLLPfkimDFEWiRSalTTGEITRTYFRVQQFiKAdKDKVLIINPT 244
Cdd:cd23991  113 LVtanpsiisikYAKLNERRKPfletvsvyGDAFLLLP----AFSY-RS--NTALSFKVYYTLEDF-KA-KQKVIFFHPI 183

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 245 FFKYVCDHWTEHHGRYP--STGMTALVFALHICDEVSVFGYGADSNGN-----WHHYWEN 297
Cdd:cd23991  184 YLKHLAQFWRSKGVQVYrlSTGLMITSAALELCEEVKLYGFWPFSKNTegkpiSHHYYDN 243
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 133-282 5.43e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 61.41  E-value: 5.43e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 133 CRKCAVVGNSGNLKGSNHGKEIDAHHFVIRMNRARTAGFEPDVGIKTTHHLMYPES-SQDLQ-PGVHLVLLPFKIMDFEW 210
Cdd:cd23978    1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSvYRVLRrPQEFLNRTPETTLIFWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 211 IRSALTTGEITRTYFRVQQFIKADKD-KVLIINPTFFKYVCDHWTEHHGR-------YPSTGMTALVFALHICDEVSVFG 282
Cdd:cd23978   81 PPNKMQKDGKSNLFRIIQRASMTFPNmSAFVVSPRRMRQFDDLFRGETGRdrkkshsWLSTGWFTMVIAVELCDNVHVYG 160
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 132-190 1.52e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 60.65  E-value: 1.52e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 948284190 132 HCRKCAVVGNSGNLKGSNHGKEIDAHHFVIRMNRARTAGFEPDVGIKTTHHLMYPESSQ 190
Cdd:cd23976   14 HCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQ 72
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 134-311 2.66e-10

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 60.24  E-value: 2.66e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 134 RKCAVVGNSGNLKGSNHGKEIDAHHFVIRMNRAR-TAGFEPDVGIKTTHHLMYP----ESSQDLQ----PGVHL------ 198
Cdd:cd23990   65 KKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPiSEKYVRDVGVKTDVVTINPsiitERFHKLEkwrrPFYEVlqvyen 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 199 --VLLPfkimdfewirsALTTGEITRTYFRVQQFIK--ADKDKVLIINPTFFKYVCDHWTEH--HGRYPSTGMTALVFAL 272
Cdd:cd23990  145 asVVLP-----------AFYNTRNTDVSIRVKYVLDdfESQQAVYYFHPQYLLNVSRFWLRQgvRAKRISSGLMLVTAAL 213

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 948284190 273 HICDEVSVFGYGA---DSNGNW--HHYWENNRNggafrRTGVHS 311
Cdd:cd23990  214 ELCEEVHLYGFWAfpmNPSGIFitHHYYDNVKP-----RPGFHA 252
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 134-283 2.77e-10

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 60.24  E-value: 2.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 134 RKCAVVGNSGNLKGSNHGKEIDAHHFVIRMNRARTAGFEPDVGIKTT-------------HHLMypESSqdLQPGVHLVL 200
Cdd:cd23986   50 RSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTiriinsqiltnpnHHFI--DSS--LYKDVILVA 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 201 ---LPFKIMDFEWIRSA----LTTGEITRTYFRVQQFikadkdkvLIINPTFFKYVCDHWTEHHGRY-----PSTGMTAL 268
Cdd:cd23986  126 wdpAPYSANLHKWYKKPdynlFTPYVQYRKRNPNQPF--------YILHPKFIWQLWDIIQENTQEKiqpnpPSSGFIGI 197

                        170
                 ....*....|....*
gi 948284190 269 VFALHICDEVSVFGY 283
Cdd:cd23986  198 LIMMSMCREVHVYEY 212
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 133-300 5.27e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 58.79  E-value: 5.27e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 133 CRKCAVVGNSGNLKGSNHGKEIDAHHFVIRMNRARTAGFEPDVGIKTT----HHLMYPESSQDLQ-------PGVHLVLL 201
Cdd:cd23975    1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTirvvSHTSVPLLLKNPDyffketnETIYVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 948284190 202 PFKIMDFEwiRSALTTGEITRTyfrVQQFIKAdkdKVLIINPTFFKYvCDH-WTEHHGR-------YPSTGMTALVFALH 273
Cdd:cd23975   81 PFRNMRKD--GKGIVYNMLKKA---VESYPQA---KIYVTTEKRMSY-CDTvFKKETGKdrvqsgsYLSTGWFTLILAMD 151

                        170       180       190
                 ....*....|....*....|....*....|....
gi 948284190 274 ICDEVSVFGYGAD----SNGNW---HHYWENNRN 300
Cdd:cd23975  152 ACYGIHVYGMINDtyckTEGYRkvpYHYYEPGRD 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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