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Conserved domains on  [gi|949394728|ref|NP_001303939|]
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vascular endothelial growth factor A, long form isoform VEGF-Ax precursor [Homo sapiens]

Protein Classification

PDGF and VEGF_C domain-containing protein( domain architecture ID 11255541)

PDGF and VEGF_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 50-132 6.24e-40

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


:

Pssm-ID: 197537  Cd Length: 83  Bit Score: 131.39  E-value: 6.24e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949394728    50 SYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCE 129
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRPLSQHLVEVSFEEHTKCE 80


                   ...
gi 949394728   130 CRP 132
Cdd:smart00141  81 CRP 83
VEGF_C pfam14554
VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been ...
 143-191 3.07e-25

VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been shown to have heparin binding activity.


:

Pssm-ID: 405273  Cd Length: 49  Bit Score: 93.14  E-value: 3.07e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 949394728  143 CGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR 191
Cdd:pfam14554   1 CSTCSERRKRLFVQDPETCKCSCKHTDADCKSRQLELNERTCRCDKPRR 49
 
Name Accession Description Interval E-value
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 50-132 6.24e-40

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 131.39  E-value: 6.24e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949394728    50 SYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCE 129
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRPLSQHLVEVSFEEHTKCE 80


                   ...
gi 949394728   130 CRP 132
Cdd:smart00141  81 CRP 83
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 50-133 2.87e-35

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 119.78  E-value: 2.87e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949394728  50 SYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPH--QGQHIGEMSFLQHNK 127
Cdd:cd00135    1 SSCKPRETLVEISEELPDETNTIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPKrkPRSKLVEISFEEHTE 80


                 ....*.
gi 949394728 128 CECRPK 133
Cdd:cd00135   81 CECRPR 86
PDGF pfam00341
PDGF/VEGF domain;
52-130 4.96e-34

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 116.62  E-value: 4.96e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949394728   52 CHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIK---PHQGQHIGEMSFLQHNKC 128
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFKPSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEyapRRPSPELVEVSFEEHVQC 80


                  ..
gi 949394728  129 EC 130
Cdd:pfam00341  81 EC 82
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 22-133 1.74e-28

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 104.32  E-value: 1.74e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949394728  22 KWSQAAPMAEGGGqnhHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESN 101
Cdd:PHA02661  21 PWCFSGSTGSSSA---SSLSSWLDTSDKSSCQPRDTVVQLSDEYPGNTNDRYNPRCVTVRRCGGCCNDESQICTPTETSN 97

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 949394728 102 ITMQIM----RIKPHQGQHIGEMSFLQHNKCECRPK 133
Cdd:PHA02661  98 VTVTVMltsvSGSTGATSNFQTISVEEHTKCKCEFK 133
VEGF_C pfam14554
VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been ...
 143-191 3.07e-25

VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been shown to have heparin binding activity.


Pssm-ID: 405273  Cd Length: 49  Bit Score: 93.14  E-value: 3.07e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 949394728  143 CGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR 191
Cdd:pfam14554   1 CSTCSERRKRLFVQDPETCKCSCKHTDADCKSRQLELNERTCRCDKPRR 49
 
Name Accession Description Interval E-value
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 50-132 6.24e-40

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 131.39  E-value: 6.24e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949394728    50 SYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCE 129
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRPLSQHLVEVSFEEHTKCE 80


                   ...
gi 949394728   130 CRP 132
Cdd:smart00141  81 CRP 83
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 50-133 2.87e-35

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 119.78  E-value: 2.87e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949394728  50 SYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPH--QGQHIGEMSFLQHNK 127
Cdd:cd00135    1 SSCKPRETLVEISEELPDETNTIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPKrkPRSKLVEISFEEHTE 80


                 ....*.
gi 949394728 128 CECRPK 133
Cdd:cd00135   81 CECRPR 86
PDGF pfam00341
PDGF/VEGF domain;
52-130 4.96e-34

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 116.62  E-value: 4.96e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949394728   52 CHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIK---PHQGQHIGEMSFLQHNKC 128
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFKPSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEyapRRPSPELVEVSFEEHVQC 80


                  ..
gi 949394728  129 EC 130
Cdd:pfam00341  81 EC 82
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 22-133 1.74e-28

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 104.32  E-value: 1.74e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949394728  22 KWSQAAPMAEGGGqnhHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESN 101
Cdd:PHA02661  21 PWCFSGSTGSSSA---SSLSSWLDTSDKSSCQPRDTVVQLSDEYPGNTNDRYNPRCVTVRRCGGCCNDESQICTPTETSN 97

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 949394728 102 ITMQIM----RIKPHQGQHIGEMSFLQHNKCECRPK 133
Cdd:PHA02661  98 VTVTVMltsvSGSTGATSNFQTISVEEHTKCKCEFK 133
VEGF_C pfam14554
VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been ...
 143-191 3.07e-25

VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been shown to have heparin binding activity.


Pssm-ID: 405273  Cd Length: 49  Bit Score: 93.14  E-value: 3.07e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 949394728  143 CGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR 191
Cdd:pfam14554   1 CSTCSERRKRLFVQDPETCKCSCKHTDADCKSRQLELNERTCRCDKPRR 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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